Base de dados : MEDLINE Pesquisa : B01.650.940.800.575.912.250.100.192 [Categoria DeCS] Referências encontradas : 23 [refinar] Mostrando: 1 .. 10   no formato [Detalhado]

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[PMID]: 28116906 [Au] Autor: De Mieri M; Monteleone G; Ismajili I; Kaiser M; Hamburger M [Ad] Endereço: Department of Pharmaceutical Biology, University of Basel , Klingelbergstrasse 50, 4056 Basel, Switzerland. [Ti] Título: Antiprotozoal Activity-Based Profiling of a Dichloromethane Extract from Anthemis nobilis Flowers. [So] Source: J Nat Prod;80(2):459-470, 2017 Feb 24. [Is] ISSN: 1520-6025 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: A dichlomethane extract of Anthemis nobilis flower cones showed promising in vitro antiprotozoal activity against Trypanosoma brucei rhodesiense and Leishmania donovani, with IC values of 1.43 ± 0.50 and 1.40 ± 0.07 µg/mL, respectively. A comprehensive profiling of the most active fractions afforded 19 sesquiterpene lactones, including 15 germacranolides, two seco-sesquiterpenes, one guaianolide sesquiterpene lactone, and one cadinane acid. Of these, 13 compounds were found to be new natural products. The compounds were characterized by extensive spectroscopic data analysis (1D and 2D NMR, HRMS, circular dichroism) and computational methods, and their in vitro antiprotozoal activity was evaluated. The furanoheliangolide derivative 15 showed high potency and selectivity in vitro against T. b. rhodesiense bloodstream forms (IC 0.08 ± 0.01 µM; SI 63). In silico calculations were consistent with the drug-like properties of 15. [Mh] Termos MeSH primário: Antiprotozoários/isolamento & purificação Antiprotozoários/farmacologia Flores/química Sesquiterpenos de Germacrano/isolamento & purificação Sesquiterpenos de Germacrano/farmacologia Sesquiterpenos/isolamento & purificação Sesquiterpenos/farmacologia Tripanossomicidas/isolamento & purificação Tripanossomicidas/farmacologia [Mh] Termos MeSH secundário: Animais Antiprotozoários/química Hidrocarbonetos Aromáticos com Pontes/farmacologia Chamaemelum Furanos/farmacologia Lactonas/química Leishmania donovani/efeitos dos fármacos Cloreto de Metileno Estrutura Molecular Plasmodium falciparum/efeitos dos fármacos Sesquiterpenos/química Sesquiterpenos de Germacrano/química Tripanossomicidas/química Trypanosoma brucei rhodesiense/efeitos dos fármacos Trypanosoma cruzi/efeitos dos fármacos [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Antiprotozoal Agents); 0 (Bridged-Ring Compounds); 0 (Furans); 0 (Lactones); 0 (Sesquiterpenes); 0 (Sesquiterpenes, Germacrane); 0 (Trypanocidal Agents); 0 (cadinane); 0 (furanoheliangolide); 0 (germacranolide); 588X2YUY0A (Methylene Chloride) [Em] Mês de entrada: 1707 [Cu] Atualização por classe: 170714 [Lr] Data última revisão: 170714 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170125 [St] Status: MEDLINE [do] DOI: 10.1021/acs.jnatprod.6b00980

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[PMID]: 27005600 [Au] Autor: Cheng S; Wang X; Xu F; Chen Q; Tao T; Lei J; Zhang W; Liao Y; Chang J; Li X [Ad] Endereço: School of Biology and Pharmaceutical Engineering, Wuhan Polytechnic University, Wuhan 430023, China. s_y_cheng@sina.com. [Ti] Título: Cloning, Expression Profiling and Functional Analysis of CnHMGS, a Gene Encoding 3-hydroxy-3-Methylglutaryl Coenzyme A Synthase from Chamaemelum nobile. [So] Source: Molecules;21(3):316, 2016 Mar 08. [Is] ISSN: 1420-3049 [Cp] País de publicação: Switzerland [La] Idioma: eng [Ab] Resumo: Roman chamomile (Chamaemelum nobile L.) is renowned for its production of essential oils, which major components are sesquiterpenoids. As the important enzyme in the sesquiterpenoid biosynthesis pathway, 3-hydroxy-3-methylglutaryl coenzyme A synthase (HMGS) catalyze the crucial step in the mevalonate pathway in plants. To isolate and identify the functional genes involved in the sesquiterpene biosynthesis of C. nobile L., a HMGS gene designated as CnHMGS (GenBank Accession No. KU529969) was cloned from C. nobile. The cDNA sequence of CnHMGS contained a 1377 bp open reading frame encoding a 458-amino-acid protein. The sequence of the CnHMGS protein was highly homologous to those of HMGS proteins from other plant species. Phylogenetic tree analysis revealed that CnHMGS clustered with the HMGS of Asteraceae in the dicotyledon clade. Further functional complementation of CnHMGS in the mutant yeast strain YSC6274 lacking HMGS activity demonstrated that the cloned CnHMGS cDNA encodes a functional HMGS. Transcript profile analysis indicated that CnHMGS was preferentially expressed in flowers and roots of C. nobile. The expression of CnHMGS could be upregulated by exogenous elicitors, including methyl jasmonate and salicylic acid, suggesting that CnHMGS was elicitor-responsive. The characterization and expression analysis of CnHMGS is helpful to understand the biosynthesis of sesquiterpenoid in C. nobile at the molecular level and also provides molecular wealth for the biotechnological improvement of this important medicinal plant. [Mh] Termos MeSH primário: Chamaemelum/enzimologia Hidroximetilglutaril-CoA Sintase/genética Filogenia [Mh] Termos MeSH secundário: Sequência de Aminoácidos/genética Asteraceae/genética Sequência de Bases Clonagem Molecular DNA Complementar/genética Regulação Enzimológica da Expressão Gênica Hidroximetilglutaril-CoA Sintase/biossíntese Hidroximetilglutaril-CoA Sintase/química Ácido Mevalônico/metabolismo Homologia de Sequência de Aminoácidos [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nome de substância: 0 (DNA, Complementary); EC 2.3.3.10 (Hydroxymethylglutaryl-CoA Synthase); S5UOB36OCZ (Mevalonic Acid) [Em] Mês de entrada: 1612 [Cu] Atualização por classe: 161230 [Lr] Data última revisão: 161230 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 160324 [St] Status: MEDLINE

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[PMID]: 26706134 [Au] Autor: Sharifzadeh A; Javan AJ; Shokri H; Abbaszadeh S; Keykhosravy K [Ad] Endereço: Mycology research center, faculty of veterinary medicine, university of Tehran, Azadi Street, Tehran, Iran. Electronic address: asharifzadeh@ut.ac.ir. [Ti] Título: Evaluation of antioxidant and antifungal properties of the traditional plants against foodborne fungal pathogens. [So] Source: J Mycol Med;26(1):e11-7, 2016 Mar. [Is] ISSN: 1773-0449 [Cp] País de publicação: France [La] Idioma: eng [Ab] Resumo: OBJECTIVE: To determine the antioxidant and antifungal activities of the essential oils from five aromatic herbs, including Thymus vulgaris, Chamaemelum nobile, Ziziphora clinopodioides, Zingiber officinale and Cuminum cyminum, against different Aspergillus and Penicillium species. METHODS: The oils were subjected to screening for their possible antioxidant activity using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay. The susceptibility test for the oils was carried out in terms of minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) using microdilution method. RESULTS: The values of the essential oils in DPPH assay were as follows: T. vulgaris (450.11±5.23 µg/mL), Ch. nobile (602.73±4.8 µg/mL), Ziz. clinopodioides (1238.82±9.3 µg/mL), Cu. cyminum (1255.52±8.92 µg/mL) and Zin. officinale (5595.06±8.24 µg/mL). Our findings also indicated a strong activity against tested fungi for the oil of T. vulgaris (1250 µg/mL), followed by Cu. cyminum (1416 µg/mL), Zin. officinale (1833 µg/mL), Ziz. clinopodioides (2166 µg/mL) and Ch. nobile (3750 µg/mL). This study confirmed the excellent antifungal and antioxidant properties of the essential oils, especially T. vulgaris, against foodborne pathogenic fungi. CONCLUSION: Owing to their strong protective features, these oils could be used in ethno-medicine as preventers of lipid peroxidation and cellular damage, and in food industries as preservers of foodstuffs against spoilage fungi. Also, they could be the candidates to develop new antibiotics and disinfectants to control infective agents. [Mh] Termos MeSH primário: Antifúngicos/farmacologia Antioxidantes/farmacologia Microbiologia de Alimentos Fungos/efeitos dos fármacos Óleos Voláteis/farmacologia Extratos Vegetais/farmacologia [Mh] Termos MeSH secundário: Chamaemelum/química Cuminum/química Gengibre/química Lamiaceae/química Thymus (Planta)/química [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nome de substância: 0 (Antifungal Agents); 0 (Antioxidants); 0 (Oils, Volatile); 0 (Plant Extracts) [Em] Mês de entrada: 1704 [Cu] Atualização por classe: 170419 [Lr] Data última revisão: 170419 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 151227 [St] Status: MEDLINE

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[PMID]: 26312934 [Au] Autor: Kazemian H; Ghafourian S; Heidari H; Amiri P; Yamchi JK; Shavalipour A; Houri H; Maleki A; Sadeghifard N [Ad] Endereço: Clinical Microbiology Research Center, Ilam University of Medical Sciences, Ilam, IR. [Ti] Título: Antibacterial, anti-swarming and anti-biofilm formation activities of Chamaemelum nobile against Pseudomonas aeruginosa. [So] Source: Rev Soc Bras Med Trop;48(4):432-6, 2015 Jul-Aug. [Is] ISSN: 1678-9849 [Cp] País de publicação: Brazil [La] Idioma: eng [Ab] Resumo: INTRODUCTION: Chamomile (Chamaemelum nobile) is widely used throughout the world, and has anti-inflammatory, deodorant, bacteriostatic, antimicrobial, carminative, sedative, antiseptic, anti-catarrhal, and spasmolytic properties. Because of the increasing incidence of drug-resistant bacteria, the development of natural antibacterial sources such as medical herbs for the treatment of infectious diseases is necessary. Extracts from different plant parts such as the leaves, flowers, fruit, and bark of Combretum albiflorum, Laurus nobilis , and Sonchus oleraceus were found to possess anti-quorum sensing (QS) activities. In this study, we evaluated the effect of C. nobile against Pseudomonas aeruginosa biofilm formation. METHODS: The P. aeruginosa samples were isolated from patients with different types of infection, including wound infection, septicemia, and urinary tract infection. The flowers of C. nobile were dried and the extract was removed using a rotary device and then dissolved in dimethyl sulfoxide at pH 7.4. The microdilution method was used to evaluate the minimum inhibitory concentration (MIC) of this extract on P. aeruginosa , and biofilm inhibition was assayed. RESULTS: Eighty percent of the isolated samples (16/20) could form a biofilm, and most of these were isolated from wound infections. The biofilm inhibitory concentration of the C. nobile extract was 6.25-25mg/ml, whereas the MIC was 12.5-50mg/ml. CONCLUSIONS: The anti-QS property of C. nobile may play an important role in its antibacterial activity, thus offering an additional strategy in the fight against bacterial infections. However, molecular investigation is required to explore the exact mechanisms of the antibacterial action and functions of this phytocompound. [Mh] Termos MeSH primário: Antibacterianos/farmacologia Biofilmes/efeitos dos fármacos Chamaemelum/química Extratos Vegetais/farmacologia Pseudomonas aeruginosa/efeitos dos fármacos Pseudomonas aeruginosa/fisiologia [Mh] Termos MeSH secundário: Seres Humanos Testes de Sensibilidade Microbiana Pseudomonas aeruginosa/isolamento & purificação Percepção de Quorum/efeitos dos fármacos [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Anti-Bacterial Agents); 0 (Plant Extracts) [Em] Mês de entrada: 1601 [Cu] Atualização por classe: 150828 [Lr] Data última revisão: 150828 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 150828 [St] Status: MEDLINE

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[PMID]: 26291574 [Au] Autor: Nasrollahzadeh M; Sajadi SM; Rostami-Vartooni A [Ad] Endereço: Department of Chemistry, Faculty of Science, University of Qom, Qom 37185-359, Iran. Electronic address: mahmoudnasr81@gmail.com. [Ti] Título: Green synthesis of CuO nanoparticles by aqueous extract of Anthemis nobilis flowers and their catalytic activity for the A³ coupling reaction. [So] Source: J Colloid Interface Sci;459:183-8, 2015 Dec 01. [Is] ISSN: 1095-7103 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: CuO nanoparticles (NPs) were prepared by Anthemis nobilis flowers extract as a reducing and stabilizing agent and employed in catalyzing an aldehyde-amine-alkyne coupling reaction. The synthesized CuO NPs was characterized by SEM, EDS, XRD, FT-IR and UV-visible techniques. A diverse range of propargylamines were obtained in a good to high yield. Furthermore, the separation and reuse of CuO NPs was very simple, effective and economical. [Mh] Termos MeSH primário: Chamaemelum/química Cobre/química Flores/química Nanopartículas/química Propilaminas/química Propilaminas/síntese química [Mh] Termos MeSH secundário: Catálise [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nome de substância: 0 (Propylamines); 789U1901C5 (Copper); V1XJQ704R4 (cupric oxide) [Em] Mês de entrada: 1603 [Cu] Atualização por classe: 150831 [Lr] Data última revisão: 150831 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 150821 [St] Status: MEDLINE

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[PMID]: 25740635 [Au] Autor: De Mieri M; Kaiser M; Brun R; Thormann U; Imanidis G; Hamburger M [Ad] Endereço: Department of Pharmaceutical Biology, University of Basel, Klingelbergstrasse 50, 4056 Basel, Switzerland. Electronic address: maria.demieri@unibas.ch. [Ti] Título: Anti-trypanosomal cadinanes synthesized by transannular cyclization of the natural sesquiterpene lactone nobilin. [So] Source: Bioorg Med Chem;23(7):1521-9, 2015 Apr 01. [Is] ISSN: 1464-3391 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: Acid-catalyzed transannular cyclization of the germacrene-type sesquiterpene lactone nobilin 1 was investigated with the aim of obtaining new anti-trypanosomal cadinane derivatives. The reaction was regiospecific in all tested reaction conditions. Compounds were fully characterized by spectroscopic and computational methods, and the anti-trypanosomal activity was evaluated and compared to nobilin (IC50 3.19±1.69µM). The tricyclic derivative 11 showed most potent in vitro activity against Trypanosoma brucei rhodesiense bloodstream forms (IC50 0.46±0.01µM). Acid-catalyzed transannular cyclization of natural cyclodecadienes is an efficient strategy to generate new natural product derivatives with anti-protozoal activity. [Mh] Termos MeSH primário: Bibenzilas/síntese química Lactonas/síntese química Sesquiterpenos de Germacrano/síntese química Sesquiterpenos/síntese química Tripanossomicidas/síntese química Trypanosoma brucei rhodesiense/efeitos dos fármacos [Mh] Termos MeSH secundário: Bibenzilas/farmacologia Chamaemelum Ciclização Seres Humanos Lactonas/farmacologia Sesquiterpenos/farmacologia Sesquiterpenos de Germacrano/farmacologia Tripanossomicidas/farmacologia [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (4,5-dihydroxy-3,3',alpha-trimethoxybibenzyl); 0 (Bibenzyls); 0 (Lactones); 0 (Sesquiterpenes); 0 (Sesquiterpenes, Germacrane); 0 (Trypanocidal Agents); 0 (cadinane) [Em] Mês de entrada: 1601 [Cu] Atualização por classe: 150317 [Lr] Data última revisão: 150317 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 150306 [St] Status: MEDLINE

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[PMID]: 25686107 [Au] Autor: Milsom J; Naughton R; O'Boyle A; Iqbal Z; Morgans R; Drust B; Morton JP [Ad] Endereço: a Liverpool Football Club , Melwood Training Ground , Liverpool , UK. [Ti] Título: Body composition assessment of English Premier League soccer players: a comparative DXA analysis of first team, U21 and U18 squads. [So] Source: J Sports Sci;33(17):1799-806, 2015. [Is] ISSN: 1466-447X [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: Professional soccer players from the first team (1st team, n = 27), under twenty-one (U21, n = 21) and under eighteen (U18, n = 35) squads of an English Premier League soccer team were assessed for whole body and regional estimates of body composition using dual-energy X-ray absorptiometry (DXA). Per cent body fat was lower in 1st team (10.0 ± 1.6) compared with both U21 (11.6 ± 2.5, P = 0.02) and U18 (11.4 ± 2.6, P = 0.01) players. However, this difference was not due to variations (P = 0.23) in fat mass between squads (7.8 ± 1.6 v. 8.8 ± 2.1 v. 8.2 ± 2.4 kg, respectively) but rather the presence of more lean mass in 1st team (66.9 ± 7.1 kg, P < 0.01) and U21 (64.6 ± 6.5 kg, P = 0.02) compared with U18 (60.6 ± 6.3 kg) players. Accordingly, fat mass index was not different (P = 0.138) between squads, whereas lean mass index was greater (P < 0.01) in 1st team players (20.0 ± 1.1 kg · m(-2)) compared with U18 players (18.8 ± 1.4 kg · m(-2)). Differences in lean mass were also reflective of higher lean tissue mass in all regions, for example, upper limbs/lower limbs and trunk. Data suggest that training and nutritional interventions for younger players should therefore be targeted to lean mass growth as opposed to body fat loss. [Mh] Termos MeSH primário: Distribuição da Gordura Corporal Futebol/fisiologia [Mh] Termos MeSH secundário: Absorciometria de Fóton Adolescente Chamaemelum Inglaterra Seres Humanos Masculino Educação Física e Treinamento Adulto Jovem [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1604 [Cu] Atualização por classe: 150710 [Lr] Data última revisão: 150710 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 150217 [St] Status: MEDLINE [do] DOI: 10.1080/02640414.2015.1012101

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[PMID]: 24471493 [Au] Autor: Zhao J; Khan SI; Wang M; Vasquez Y; Yang MH; Avula B; Wang YH; Avonto C; Smillie TJ; Khan IA [Ad] Endereço: National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, University of Mississippi , University, Mississippi 38677, United States. [Ti] Título: Octulosonic acid derivatives from Roman chamomile (Chamaemelum nobile) with activities against inflammation and metabolic disorder. [So] Source: J Nat Prod;77(3):509-15, 2014 Mar 28. [Is] ISSN: 1520-6025 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Six new octulosonic acid derivatives (1-6) were isolated from the flower heads of Roman chamomile (Chamaemelum nobile). Their structures were elucidated by means of spectroscopic interpretation. The biological activity of the isolated compounds was evaluated toward multiple targets related to inflammation and metabolic disorder such as NAG-1, NF-κB, iNOS, ROS, PPARα, PPARγ, and LXR. Similar to the action of NSAIDs, all the six compounds (1-6) increased NAG-1 activity 2-3-fold. They also decreased cellular oxidative stress by inhibiting ROS generation. Compounds 3, 5, and 6 activated PPARγ 1.6-2.1-fold, while PPARα was activated 1.4-fold by compounds 5 and 6 only. None of the compounds showed significant activity against iNOS or NF-κB. This is the first report of biological activity of octulosonic acid derivatives toward multiple pathways related to inflammation and metabolic disorder. The reported anti-inflammatory, hypoglycemic, antiedemic, and antioxidant activities of Roman chamomile could be partly explained as due to the presence of these constituents. [Mh] Termos MeSH primário: Anti-Inflamatórios não Esteroides/isolamento & purificação Anti-Inflamatórios não Esteroides/farmacologia Chamaemelum/química Açúcares Ácidos/isolamento & purificação Açúcares Ácidos/farmacologia [Mh] Termos MeSH secundário: Anti-Inflamatórios não Esteroides/química Flores/química Hipoglicemiantes/farmacologia Mississippi Estrutura Molecular NF-kappa B/metabolismo Óxido Nítrico Sintase Tipo II/efeitos dos fármacos Ressonância Magnética Nuclear Biomolecular Estresse Oxidativo/efeitos dos fármacos PPAR alfa/metabolismo PPAR gama/metabolismo Açúcares Ácidos/química [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S. [Nm] Nome de substância: 0 (Anti-Inflammatory Agents, Non-Steroidal); 0 (Hypoglycemic Agents); 0 (NF-kappa B); 0 (PPAR alpha); 0 (PPAR gamma); 0 (Sugar Acids); EC 1.14.13.39 (NOS2 protein, human); EC 1.14.13.39 (Nitric Oxide Synthase Type II) [Em] Mês de entrada: 1407 [Cu] Atualização por classe: 170624 [Lr] Data última revisão: 170624 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 140130 [St] Status: MEDLINE [do] DOI: 10.1021/np400780n

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[PMID]: 23725305 [Au] Autor: Rastegar H; Ahmadi Ashtiani H; Aghaei M; Ehsani A; Barikbin B [Ad] Endereço: Food and Drug Control Laboratory and Research Center, Tehran, Iran. [Ti] Título: Combination of herbal extracts and platelet-rich plasma induced dermal papilla cell proliferation: involvement of ERK and Akt pathways. [So] Source: J Cosmet Dermatol;12(2):116-22, 2013 Jun. [Is] ISSN: 1473-2165 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: BACKGROUND AND AIMS: Recently, platelet-rich plasma (PRP) has attracted attention in various medical fields, including plastic surgery, treatment for problematic wounds, and dermatology. Specifically, PRP has been tested during hair transplantation to reduce swelling and pain and to increase hair density. We examined the effects of PRP and herbal extracts combination in order to identify potential stimulants of hair growth. METHODS: PRP was prepared using the double-spin method and applied to dermal papilla cells (DPCs). MTT viability test and BrdU cell proliferation assay were used to study the effect of herbal extracts and PRP on proliferation of DPCs. To understand the mechanisms of herbal extracts and PRP involved in the regulation of hair growth, we evaluated signaling pathways and measured the expressions of ERK and Akt, by Western blot. RESULTS: Combination of herbal extracts and PRP was found to induce significant proliferation of human DPCs at concentrations ranging from 1.5% to 4.5%. The present study shows that herbal extracts and PRP affect the expressions of extracellular signal-regulated kinase (ERK) and Akt in DPCs. CONCLUSION: In this study, we have shown that combination of herbal extracts and PRP plays an active role in promoting the proliferation of human dermal papilla (DP) cells via the regulation of ERK and Akt proteins, and this may be applicable to the future development of herbal extracts and PRP combination therapeutics to enhance hair growth. [Mh] Termos MeSH primário: Folículo Piloso/efeitos dos fármacos Folículo Piloso/metabolismo Extratos Vegetais/farmacologia Plasma Rico em Plaquetas [Mh] Termos MeSH secundário: Althaea Proliferação Celular/efeitos dos fármacos Células Cultivadas Chamaemelum Ciclina D1/metabolismo Quinase 4 Dependente de Ciclina/metabolismo MAP Quinases Reguladas por Sinal Extracelular/metabolismo Frutas Seres Humanos Persea Fosforilação/efeitos dos fármacos Folhas de Planta Proteínas Proto-Oncogênicas c-akt/metabolismo Rosmarinus Transdução de Sinais Thymus (Planta) Urtica dioica [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Plant Extracts); 136601-57-5 (Cyclin D1); EC 2.7.11.1 (Proto-Oncogene Proteins c-akt); EC 2.7.11.22 (CDK4 protein, human); EC 2.7.11.22 (Cyclin-Dependent Kinase 4); EC 2.7.11.24 (Extracellular Signal-Regulated MAP Kinases) [Em] Mês de entrada: 1402 [Cu] Atualização por classe: 130603 [Lr] Data última revisão: 130603 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 130604 [St] Status: MEDLINE [do] DOI: 10.1111/jocd.12033

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[PMID]: 23672040 [Au] Autor: Han SL; Li XX; Mian QH; Lan W; Liu Y [Ad] Endereço: Xinjiang Medical University, Urumqi 830054, China. 1437155839@qq.com [Ti] Título: [Comparison of antioxidant activity between two species of chamomiles produced in Xinjiang by TLC-bioautography]. [So] Source: Zhongguo Zhong Yao Za Zhi;38(2):193-8, 2013 Jan. [Is] ISSN: 1001-5302 [Cp] País de publicação: China [La] Idioma: chi [Ab] Resumo: OBJECTIVE: To compare the antioxidant active components from two species of chamomile-matricaria and Roman chamomile produced in Xinjiang. METHOD: The TLC-bioautography was used, with 1,1-Diphenyl-2-picrylhydrazyl (DPPH) radical as the experimental model. The peak areas of various antioxidant components were obtained by TLC-scanning for analyzing antioxidant active components contained in volatile oil extracts and flavone extracts from the two species of chamomiles. The total peak area was taken as the indicator for comparing the antioxidant capacities of the two types of extracts, and comparing them with the total antioxidant activity of flavone extracts of the two species of chamomiles. RESULTS: According to the result of TLC-bioautography in volatile oil extracts from the two species of chamomiles, volatile oil extracts from chamomile showed four white antioxidant spots, including en-yne-dicycloether, and volatile oil extracts from Roman chamomile showed only one white antioxidant spot. The TLC-scanning result showed that the peak area of antioxidant spots of volatile oil extracts from chamomile was significantly larger than that of volatile oil extracts from Roman chamomile. According to the test on the antioxidant activity of the two species of chamomiles with ultraviolet-visible spectrophotometry, the concentration of chamomile after scavenging 50% of DPPH radicals was 0.66 g x L(-1), whereas the figure for Roman chamomile was 0.33 g x L(-1). According to the result of TLC-bioautography in flavone extracts from the two species of chamomiles, flavone extracts from chamomile showed seven yellowish antioxidant spots, including apigenin and apigenin-7-glucoside, and flavone extracts of Roman chamomile showed eight yellowish antioxidant spots, including apigenin and apigenin-7-glucoside. The TLC-scanning results showed that the peak area of antioxidant spots of flavone extracts from Roman chamomile was significantly larger than that of flavone extracts from chamomile. CONCLUSION: Volatile oil extracts from the two species of chamomiles have significant difference in the antioxidant activity in TLC-bioautography. Specifically, the antioxidant activity of volatile oil extracts from chamomile is stronger than volatile oil extracts from Roman chamomile; the known antioxidant active components in volatile oil extracts from chamomile is en-yne-dicycloether, while all of the other three antioxidant active components as well as antioxidant active components in volatile oil extracts from Roman chamomile are unknown components and remain to be further determined. Considering the significant difference in the number of antioxidant active spots in volatile oil extracts from the two species of chamomiles, the result can be applied to distinguish the two species of chamomiles. The antioxidant activity determination result for flavone extracts from two species of chamomiles was consistent with the result of TLC-bioautography, showing that flavone extracts from chamomile and Roman chamomile are more antioxidant active, while that of Roman chamomile is stronger than chamomile. Flavone extracts from both of the two species of chamomiles contain apigenin and pigenin-7-glucoside, which are known, while all of the other five antioxidant active components contained in flavone extracts from chamomile and the other six antioxidant active components contained in flavone extracts from Roman chamomile are unknown and remain to be further identified. The method lays a foundation for further identification of antioxidant active components contained in chamomile. [Mh] Termos MeSH primário: Antioxidantes/química Chamaemelum/química Cromatografia em Camada Delgada/métodos Flavonas/química Matricaria/química Óleos Voláteis/química [Mh] Termos MeSH secundário: Antioxidantes/isolamento & purificação Apigenina/química Apigenina/isolamento & purificação Compostos de Bifenilo/metabolismo Flavonas/isolamento & purificação Depuradores de Radicais Livres/química Depuradores de Radicais Livres/isolamento & purificação Glucosídeos/química Glucosídeos/isolamento & purificação Óleos Voláteis/isolamento & purificação Picratos/metabolismo Extratos Vegetais/química Extratos Vegetais/isolamento & purificação Óleos Vegetais/química Óleos Vegetais/isolamento & purificação [Pt] Tipo de publicação: COMPARATIVE STUDY; JOURNAL ARTICLE [Nm] Nome de substância: 0 (Antioxidants); 0 (Biphenyl Compounds); 0 (Flavones); 0 (Free Radical Scavengers); 0 (Glucosides); 0 (Oils, Volatile); 0 (Picrates); 0 (Plant Extracts); 0 (Plant Oils); 7V515PI7F6 (Apigenin); DFD3H4VGDH (1,1-diphenyl-2-picrylhydrazyl) [Em] Mês de entrada: 1406 [Cu] Atualização por classe: 161125 [Lr] Data última revisão: 161125 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 130516 [St] Status: MEDLINE

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