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Pesquisa : B01.650.940.800.575.912.250.100.203 [Categoria DeCS]
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[PMID]:29304104
[Au] Autor:Uyi OO; Zachariades C; Heshula LU; Hill MP
[Ad] Endereço:Department of Zoology and Entomology, University of Fort Hare, Alice, South Africa.
[Ti] Título:Developmental and reproductive performance of a specialist herbivore depend on seasonality of, and light conditions experienced by, the host plant.
[So] Source:PLoS One;13(1):e0190700, 2018.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Host plant phenology (as influenced by seasonality) and light-mediated changes in the phenotypic and phytochemical properties of leaves have been hypothesised to equivocally influence insect herbivore performance. Here, we examined the effects of seasonality, through host plant phenology (late growth-season = autumn vs flowering-season = winter) and light environment (shade vs full-sun habitat) on the leaf characteristics of the invasive alien plant, Chromolaena odorata. In addition, the performance of a specialist folivore, Pareuchaetes insulata, feeding on leaves obtained from both shaded and full-sun habitats during autumn and winter, was evaluated over two generations. Foliar nitrogen and magnesium contents were generally higher in shaded plants with much higher levels during winter. Leaf water content was higher in shaded and in autumn plants. Total non-structural carbohydrate (TNC) and phosphorus contents did not differ as a function of season, but were higher in shaded foliage compared to full-sun leaves. Leaf toughness was noticeably higher on plants growing in full-sun during winter. With the exception of shaded leaves in autumn that supported the best performance [fastest development, heaviest pupal mass, and highest growth rate and Host Suitability Index (HSI) score], full-sun foliage in autumn surprisingly also supported an improved performance of the moth compared to shaded or full-sun leaves in winter. Our findings suggest that shaded and autumn foliage are nutritionally more suitable for the growth and reproduction of P. insulata. However, the heavier pupal mass, increased number of eggs and higher HSI score in individuals that fed on full-sun foliage in autumn compared to their counterparts that fed on shaded or full-sun foliage in winter suggest that full-sun foliage during autumn is also a suitable food source for larvae of the moth. In sum, our study demonstrates that seasonal and light-modulated changes in leaf characteristics can affect insect folivore performance in ways that are not linear.
[Mh] Termos MeSH primário: Chromolaena/fisiologia
Herbivoria
Mariposas/fisiologia
Estações do Ano
Luz Solar
[Mh] Termos MeSH secundário: Animais
Biomassa
Chromolaena/efeitos da radiação
Comportamento Alimentar
Feminino
Espécies Introduzidas
Magnésio/metabolismo
Masculino
Nitrogênio/metabolismo
Folhas de Planta/fisiologia
Reprodução/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
I38ZP9992A (Magnesium); N762921K75 (Nitrogen)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180210
[Lr] Data última revisão:
180210
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180106
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0190700


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[PMID]:28260703
[Au] Autor:Boudjeko T; Tchinda RA; Zitouni M; Nana JA; Lerat S; Beaulieu C
[Ad] Endereço:Laboratory of Phytoprotection and Valorization of Plants Resources, Biotechnology Centre-Nkolbisson.
[Ti] Título:Streptomyces cameroonensis sp. nov., a Geldanamycin Producer That Promotes Theobroma cacao Growth.
[So] Source:Microbes Environ;32(1):24-31, 2017 Mar 31.
[Is] ISSN:1347-4405
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:The taxonomy of an actinobacterial strain, designated JJY4 , was established using a polyphasic approach. JJY4 was isolated from the rhizosphere of Chromolaena odorata in Yaoundé (Cameroon) during a project for the selection of biological control agents. Strain JJY4 exhibited antimicrobial activities against bacteria, fungi, and oomycetes. Strain JJY4 also exhibited the traits of plant growth-promoting rhizobacteria such as the solubilization of inorganic phosphate, production of siderophores and indole-3-acetic acid, and 1-aminocyclopropane-1-carboxylate deaminase activity. In planta assays performed on cocoa plantlets confirmed that strain JJY4 exhibited strong abilities to promote plant growth and protect against Phytophthora megakarya, the main causal agent of cocoa pod rot. The formation of rugose-ornamented spores in spiral spore chains by strain JJY4 is a typical feature of members found in the Streptomyces violaceusniger clade and, similar to some members of the clade, strain JJY4 produces geldanamycin. A phylogenetic analysis based on 16S rRNA gene sequences confirmed this classification and suggests that strain JJY4 be added to the subclade constituted of the type strains Streptomyces malaysiensis DSM 41697 and Streptomyces samsunensis DSM 42010 . However, DNA-DNA relatedness and physiological characteristics allowed for the differentiation of strain JJY4 from its closest phylogenetic relatives. Based on these results, strain JJY4 (=NRRL B-65369, =NBRC 112705) appears to represent a novel species in the S. violaceusniger clade for which the proposed name is Streptomyces cameroonensis sp. nov.
[Mh] Termos MeSH primário: Anti-Infecciosos/metabolismo
Benzoquinonas/metabolismo
Cacau/crescimento & desenvolvimento
Cacau/microbiologia
Lactamas Macrocíclicas/metabolismo
Streptomyces/classificação
Streptomyces/isolamento & purificação
[Mh] Termos MeSH secundário: Antibiose
Técnicas de Tipagem Bacteriana
Camarões
Chromolaena/microbiologia
Análise por Conglomerados
DNA Bacteriano/química
DNA Bacteriano/genética
DNA Ribossômico/química
DNA Ribossômico/genética
Microscopia Eletrônica de Varredura
Hibridização de Ácido Nucleico
Filogenia
Phytophthora/crescimento & desenvolvimento
Reguladores de Crescimento de Planta/metabolismo
Raízes de Plantas/microbiologia
RNA Ribossômico 16S/genética
Análise de Sequência de DNA
Microbiologia do Solo
Streptomyces/genética
Streptomyces/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Infective Agents); 0 (Benzoquinones); 0 (DNA, Bacterial); 0 (DNA, Ribosomal); 0 (Lactams, Macrocyclic); 0 (Plant Growth Regulators); 0 (RNA, Ribosomal, 16S); Z3K3VJ16KU (geldanamycin)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170414
[Lr] Data última revisão:
170414
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170307
[St] Status:MEDLINE
[do] DOI:10.1264/jsme2.ME16095


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[PMID]:28112383
[Au] Autor:Vijayaraghavan K; Rajkumar J; Bukhari SN; Al-Sayed B; Seyed MA
[Ad] Endereço:School of Life Sciences, B.S. Abdur Rahman University, Chennai, Tamil Nadu 600048, India.
[Ti] Título:Chromolaena odorata: A neglected weed with a wide spectrum of pharmacological activities (Review).
[So] Source:Mol Med Rep;15(3):1007-1016, 2017 Mar.
[Is] ISSN:1791-3004
[Cp] País de publicação:Greece
[La] Idioma:eng
[Ab] Resumo:The study of wound­healing plants has acquired an interdisciplinary nature with a systematic investigational approach. Several biochemicals are involved in the healing process of the body, including antioxidants and cytokines. Although several pharmaceutical preparations and formulations are available for wound care and management, it remains necessary to search for efficacious treatments, as certain current formulations cause adverse effects or lack efficacy. Phytochemicals or biomarkers from numerous plants suggest they have positive effects on different stages of the wound healing process via various mechanisms. Several herbal medicines have displayed marked activity in the management of wounds and various natural compounds have verified in vivo wound healing potential, and can, therefore, be considered as potential drugs of natural origin. Chromolaena odorata (L.) R.M. King and H. Robinson is considered a tropical weed. However, it exhibits anti­inflammatory, antipyretic, analgesic, antimicrobial, cytotoxic and numerous other relevant medicinal properties on an appreciable scale, and is known in some parts of the world as a traditional medicine used to treat various ailments. To understand its specific role as nature's gift for healing wounds and its contribution to affordable healthcare, this plant must be scientifically assessed based on the available literature. This review aims to summarize the role of C. odorata and its biomarkers in the wound healing activities of biological systems, which are crucial to its potential future drug design, development and application for the treatment of wounds.
[Mh] Termos MeSH primário: Chromolaena
Plantas Medicinais
[Mh] Termos MeSH secundário: Chromolaena/química
Medicina Tradicional
Compostos Fitoquímicos/química
Extratos Vegetais/química
Extratos Vegetais/farmacologia
Preparações de Plantas/química
Preparações de Plantas/farmacologia
Plantas Medicinais/química
Cicatrização/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Phytochemicals); 0 (Plant Extracts); 0 (Plant Preparations)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170509
[Lr] Data última revisão:
170509
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170124
[St] Status:MEDLINE
[do] DOI:10.3892/mmr.2017.6133


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[PMID]:27956328
[Au] Autor:Dahunsi SO; Oranusi S; Owolabi JB; Efeovbokhan VE
[Ad] Endereço:Biological Sciences Department, Landmark University, Nigeria.
[Ti] Título:Synergy of Siam weed (Chromolaena odorata) and poultry manure for energy generation: Effects of pretreatment methods, modeling and process optimization.
[So] Source:Bioresour Technol;225:409-417, 2017 Feb.
[Is] ISSN:1873-2976
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The co-digestion of Chromolaena odorata with poultry manure was evaluated in this study. Two samples of the weed: (A: which was pre-treated with mechanical, chemical and thermal methods) and (B: which was pretreated using mechanical and chemical methods only) were separately digested with poultry manure. Biogas generation started from the 2nd to 4th and 4th to 7th day for samples 'A' and 'B' respectively. The most desired actual biogas yield from samples 'A' and 'B' were 3884.20 and 2544.70 (10 m /kg VS) respectively and the gas composition was 68±2% Methane and 20±2% Carbon dioxide for sample A while it was 62±3% Methane and 22±2% Carbon dioxide for sample B. In all, there was a 38.06% increase in gas generation in 'A' over 'B'. The coefficient of determination (R ) for the Response Surface Methodology (RSM) model (0.9009) was high suggesting high accuracy in the modeling and prediction. The worldwide usage of C. odorata is encouraged.
[Mh] Termos MeSH primário: Biocombustíveis
Biotecnologia/métodos
Chromolaena/química
Esterco
Modelos Teóricos
Plantas Daninhas/química
[Mh] Termos MeSH secundário: Animais
Dióxido de Carbono/metabolismo
Chromolaena/metabolismo
Metano/biossíntese
Plantas Daninhas/metabolismo
Aves Domésticas
Eliminação de Resíduos Líquidos/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biofuels); 0 (Manure); 142M471B3J (Carbon Dioxide); OP0UW79H66 (Methane)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170213
[Lr] Data última revisão:
170213
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161214
[St] Status:MEDLINE


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[PMID]:27916676
[Au] Autor:Gade S; Rajamanikyam M; Vadlapudi V; Nukala KM; Aluvala R; Giddigari C; Karanam NJ; Barua NC; Pandey R; Upadhyayula VS; Sripadi P; Amanchy R; Upadhyayula SM
[Ad] Endereço:Biology Division, Council for Scientific and Industrial Research - Indian Institute of Chemical Technology (Ministry of Science and Technology), Uppal Road, Tarnaka, Hyderabad 500607, India.
[Ti] Título:Acetylcholinesterase inhibitory activity of stigmasterol & hexacosanol is responsible for larvicidal and repellent properties of Chromolaena odorata.
[So] Source:Biochim Biophys Acta;1861(3):541-550, 2017 03.
[Is] ISSN:0006-3002
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Chromolaena odorata, has been traditionally known for its insect repellent property. Aim of this study was to determine larvicidal tendency of C. odorata on Culex quinquefasciatus and isolate compounds responsible for this activity and to determine the mechanism of action of these compounds. METHODS: C. odorata plant extract was screened for mosquito larvicidal activity. The extract was fractionated using chromatography and the bioactive fraction showing larvicidal activity was identified. The chemical nature of the compounds in the bioactive fraction was determined using NMR and Mass spectrometry. RESULTS: We identified phytosterols and alkanols to be the compounds regulating larvicidal activity in the bioactive fraction of the plant extract. Stigmasterol and 1-hexacosanol were identified to be the chief orchestrators of larvicidal activity and their mode of action has been observed to be neurotoxicity. At a molecular level both stigmasterol and 1-hexacosanol were found to be inhibiting acetylcholinesterase activity in C. quinquefasciatus & A. aegypti. The acetylcholinesterase inhibitory effect was validated in vitro using recombinant acetylcholinesterase and ex vivo in larval homogenates of Culex and Aedes. Electrophysiological studies using electroantennography have shown enhanced neural response to these compounds. CONCLUSIONS: Neurotoxic effect of C. odorata derived stigmasterol and 1-hexacosanol, exerted through acetylcholinesterase inhibition was responsible for the mortality of C. quinquefasciatus, A. aegypti &Chironomus riparius. EAG studies pointed out hyper-excitability of the olfactory system by these compounds. GENERAL SIGNIFICANCE: These compounds are natural agents for mosquito control that can be used in vector control as larvicidal compounds, pending further investigations.
[Mh] Termos MeSH primário: Acetilcolinesterase/metabolismo
Inibidores da Colinesterase/farmacologia
Chromolaena/química
Álcoois Graxos/farmacologia
Inseticidas/farmacologia
Larva/efeitos dos fármacos
Estigmasterol/farmacologia
[Mh] Termos MeSH secundário: Aedes/efeitos dos fármacos
Aedes/metabolismo
Animais
Neurotoxinas/farmacologia
Fitosteróis/farmacologia
Extratos Vegetais/farmacologia
Folhas de Planta/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Cholinesterase Inhibitors); 0 (Fatty Alcohols); 0 (Insecticides); 0 (Neurotoxins); 0 (Phytosterols); 0 (Plant Extracts); 99WUK5D0Y8 (Stigmasterol); EC 3.1.1.7 (Acetylcholinesterase); M7SD300NNB (1-hexacosanol)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171019
[Lr] Data última revisão:
171019
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161206
[St] Status:MEDLINE


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[PMID]:27321410
[Au] Autor:Afolayan FID; Adegbolagun OM; Irungu B; Kangethe L; Orwa J; Anumudu CI
[Ad] Endereço:Department of Zoology, University of Ibadan, Ibadan, Nigeria; Centre for Traditional Medicine and Drugs Research, Kenya Medical Research Institute, (KEMRI), P.O. Box 54840 00200, Nairobi, Kenya. Electronic address: fidifede@gmail.com.
[Ti] Título:Antimalarial actions of Lawsonia inermis, Tithonia diversifolia and Chromolaena odorata in combination.
[So] Source:J Ethnopharmacol;191:188-194, 2016 Sep 15.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:ETHNOPHARMACOLOGICAL RELEVANCE: Chromolaena odorata, Tithonia diversifolia and Lawsonia inermis are medicinal plants used in treating malaria in traditional medicine system. Previous studies however showed that their dichloromethane, methanol (1:1) extracts were more active against Plasmodium parasite than the aqueous extracts. AIM OF THE STUDY: To determine the in vitro and in vivo antiplasmodial activity of dichloromethane, methanol (1:1) extracts of Chromolaena odorata, Tithonia diversifolia and Lawsonia inermis in combination and evaluate their safety using acute limit toxicity test. MATERIALS AND METHODS: Dichloromethane, methanol (1:1) extracts of Chromolaena odorata, Tithonia diversifolia and Lawsonia inermis leaves were combined at ratios 1:1, 1:3, 3:1, 1:5 and 5:1 using in vitro semi-automated microdilution technique against P. falciparum Chloroquine sensitive (D6) and Chloroquine resistant (W2) strains, with chloroquine and artemisinin as controls. The in vivo antiplasmodial activity of the crude extracts was carried out singly, and in combination at the different combination ratios on Plasmodium berghei Anka infected Swiss albino mice using Peters' 4-day suppressive test. Acute toxicity test was done in mice at 5000mg/kg. RESULTS: The in vitro combination of L. inermis and T. diversifolia (1:1) extracts against P. falciparum showed the highest synergy with IC50 of 0.43±0.02µg/mL and 2.55±0.19µg/mL against D6 and W2 respectively; while the combination of C. odorata with T. diversifolia and L. inermis were antagonistic. A synergy with chemosuppression of 83.6% against P. berghei infected mice was observed in L. inermis and T. diversifolia (1:1) treated animals. In contrast to the in vitro result, combination of C. odorata with T. diversifolia and L. inermis showed some degrees of synergy in vivo. Extracts were not toxic at the concentration tested. CONCLUSION: These findings rationalized the use of these plants in combination as antimalarials in traditional medicine. However, the combination of Chromolaena odorata with other medicinal plants should be used with caution because of its possible antagonistic effect.
[Mh] Termos MeSH primário: Antimaláricos/farmacologia
Asteraceae/química
Chromolaena/química
Lawsonia (Planta)/química
Malária/tratamento farmacológico
Extratos Vegetais/farmacologia
Plasmodium berghei/efeitos dos fármacos
Plasmodium falciparum/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Antimaláricos/isolamento & purificação
Antimaláricos/toxicidade
Asteraceae/toxicidade
Chromolaena/toxicidade
Modelos Animais de Doenças
Relação Dose-Resposta a Droga
Resistência a Medicamentos
Sinergismo Farmacológico
Quimioterapia Combinada
Lawsonia (Planta)/toxicidade
Malária/parasitologia
Metanol/química
Cloreto de Metileno/química
Camundongos
Testes de Sensibilidade Parasitária
Fitoterapia
Extratos Vegetais/isolamento & purificação
Extratos Vegetais/toxicidade
Folhas de Planta/química
Plantas Medicinais
Plasmodium berghei/crescimento & desenvolvimento
Plasmodium falciparum/crescimento & desenvolvimento
Solventes/química
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antimalarials); 0 (Plant Extracts); 0 (Solvents); 588X2YUY0A (Methylene Chloride); Y4S76JWI15 (Methanol)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170808
[Lr] Data última revisão:
170808
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160621
[St] Status:MEDLINE


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[PMID]:27159380
[Au] Autor:Jampasri K; Pokethitiyook P; Kruatrachue M; Ounjai P; Kumsopa A
[Ad] Endereço:a Department of Biology , Faculty of Science, Mahidol University , Bangkok , Thailand.
[Ti] Título:Phytoremediation of fuel oil and lead co-contaminated soil by Chromolaena odorata in association with Micrococcus luteus.
[So] Source:Int J Phytoremediation;18(10):994-1001, 2016 Oct 02.
[Is] ISSN:1549-7879
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Phytoremediation is widely promoted as a cost-effective technology for treating heavy metal and total petroleum hydrocarbon (TPH) co-contaminated soil. This study investigated the concurrent removal of TPHs and Pb in co-contaminated soil (27,000 mg kg(-1) TPHs, 780 mg kg(-1) Pb) by growing Siam weed (Chromolaena odorata) in a pot experiment for 90 days. There were four treatments: co-contaminated soil; co-contaminated soil with C. odorata only; co-contaminated soil with C. odorata and Micrococcus luteus inoculum; and co-contaminated soil with M. luteus only. C. odorata survived and grew well in the co-contaminated soil. C. odorata with M. luteus showed the highest Pb accumulation (513.7 mg kg(-1)) and uptake (7.7 mg plant(-1)), and the highest reduction percentage of TPHs (52.2%). The higher TPH degradation in vegetated soils indicated the interaction between the rhizosphere microorganisms and plants. The results suggested that C. odorata together with M. luteus and other rhizosphere microorganisms is a promising candidate for the removal of Pb and TPHs in co-contaminated soils.
[Mh] Termos MeSH primário: Chromolaena/metabolismo
Chromolaena/microbiologia
Óleos Combustíveis
Chumbo/metabolismo
Micrococcus luteus/metabolismo
Microbiologia do Solo
Poluentes do Solo/metabolismo
[Mh] Termos MeSH secundário: Biodegradação Ambiental
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fuel Oils); 0 (Soil Pollutants); 2P299V784P (Lead)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170406
[Lr] Data última revisão:
170406
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160510
[St] Status:MEDLINE
[do] DOI:10.1080/15226514.2016.1183568


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[PMID]:25975513
[Au] Autor:Omokhua AG; McGaw LJ; Finnie JF; Van Staden J
[Ad] Endereço:Research Centre for Plant Growth and Development, School of Life Sciences, University of KwaZulu-Natal Pietermaritzburg, Private Bag X01, Scottsville 3209, South Africa.
[Ti] Título:Chromolaena odorata (L.) R.M. King & H. Rob. (Asteraceae) in sub-Saharan Africa: A synthesis and review of its medicinal potential.
[So] Source:J Ethnopharmacol;183:112-22, 2016 May 13.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:ETHNOPHARMACOLOGICAL RELEVANCE: Chromolaena odorata (L.) R.M. King & H. Rob. (Asteraceae) is a scrambling perennial shrub that originated in the Americas, but is now common in sub-Saharan Africa, Asia and Oceania, where it has become a serious weed. The species, particularly the biotype found in Asia and West Africa, has many ethnopharmacological uses, including treatment of malaria, wounds, diarrhoea, skin infection, toothache, dysentery, stomach ache, sore throat, convulsions, piles, coughs and colds. Furthermore, no attempt has been made to synthesise and review the available literature on the usefulness of the plant in the sub-Saharan African region, hence this paper examines the beneficial attributes of C. odorata in sub-Saharan Africa. MATERIAL AND METHODS: Published information on the species was gathered by the use of different database platforms, including Google Scholar, ScienceDirect, SciFinder and Scopus. RESULTS: Records indicate that two biotypes of C. odorata are present in sub-Saharan Africa viz. the more widespread Asian/West African C. odorata biotype (AWAB) and the southern African biotype (SAB). While the usefulness of the former is well elucidated in the literature, such information on the latter is still scarce. Although the importance of AWAB C. odorata as a fallow species and as a soil fertility improvement plant in the slash and burn rotation system of agriculture in West Africa is increasingly being recognised, its usage in traditional medicinal practice is far more appreciated. The species has a wide range of ethnopharmacological uses, possibly because of the presence of flavonoids, essential oils, phenolics, tannins and saponins. The plant is reported to have antibacterial, anti-inflammatory, antioxidant, anthelminthic, antifungal, cytotoxic, anticonvulsant, antiprotozoal, antispasmodic, antipyretic and analgesic properties. CONCLUSION: While the results of this review suggest that the AWAB plant can be exploited as an alternative to other threatened plant species known to possess similar medicinal potential, the medicinal and pharmacological potential of the SAB plant remains to be established. Further studies on the phytochemistry and pharmacological properties of the SAB plants will not only advance our knowledge of ethnobotany and ethnomedicine, but may also improve the health and knowledge of the local people.
[Mh] Termos MeSH primário: Asteraceae/química
Chromolaena/química
Preparações de Plantas/química
Preparações de Plantas/uso terapêutico
[Mh] Termos MeSH secundário: África ao Sul do Saara
Etnofarmacologia/métodos
Seres Humanos
Medicina Tradicional/métodos
Fitoterapia/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Plant Preparations)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150516
[St] Status:MEDLINE


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[PMID]:26651330
[Au] Autor:Boudjeko T; Megnekou R; Woguia AL; Kegne FM; Ngomoyogoli JE; Tchapoum CD; Koum O
[Ad] Endereço:Laboratory of Phytoprotection and Valorisation of Plants Resources, Biotechnology Centre-Nkolbisson, P.O. Box 3851, Messa, Yaounde, Cameroon. boudjeko@yahoo.com.
[Ti] Título:Antioxidant and immunomodulatory properties of polysaccharides from Allanblackia floribunda Oliv stem bark and Chromolaena odorata (L.) King and H.E. Robins leaves.
[So] Source:BMC Res Notes;8:759, 2015 Dec 09.
[Is] ISSN:1756-0500
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Many plant polysaccharides have shown high antioxidant and immunostimulating properties and can be explored as novel molecules with biological properties that can potentially improve immune function. The objective of this work was to characterize soluble and cell wall polysaccharides isolated from the stem bark of Allanblackia floribunda and Chromolaena odorata leaves and to evaluate their antioxidant and immunomodulatory properties. METHODS: Three polysaccharide fractions: soluble polysaccharides (PoS), pectins (Pec) and hemicelluloses (Hem) were extracted from A. floribunda stem bark and C. odorata leaves. These samples were analysed for their proteins, phenolic compounds and total sugar contents. The monosaccharide composition was determined by gas chromatography and arabinogalactan proteins content in PoS was evaluated by rocket electrophoresis. The in vitro antioxidant activities were evaluated by 1, 1-diphenyl-2-picryl hydrazyl (DPPH) and 2,2'-azino-bis-3-éthylbenzylthiazoline-6-sulphonic acid (ABTS) radical scavenging assays and ferrous ions chelating activity. Immunomodulatory activities were performed on the peripheral blood mononuclear cells (PBMCs) using proliferation and enzyme linked immunospot (ELISPOT) method to determine the production of an interferon-gamma. RESULTS: The characterization of the various fractions showed varied metabolites in each plant. In PoS fractions, Ara and Gal were the major monosaccharides found, indicating that arabinogalactans are the primary macromolecules. Hem fractions contained predominantly Xyl and GalA for A. floribunda and Xyl (upto 80 %) for and C. odorata. A. floribunda Hem fraction and C. odorata PoS fraction showed significant DPPH and ABTS radical scavenging activities and immunostimulatory activity via stimulation of PBMC and production of IFN-γ in a dose-dependent manner. CONCLUSION: The results obtained from this study support the ethnomedicinal use of the stem bark of A. floribunda and leaves of C. odorata. Further research is necessary to have supporting evidence that the antioxidative and immunomodulative activities of these fractions are really connected to the polysaccharides and not polyphenols.
[Mh] Termos MeSH primário: Antioxidantes/farmacologia
Chromolaena/química
Clusiaceae/química
Fatores Imunológicos/farmacologia
Folhas de Planta/química
Polissacarídeos/farmacologia
[Mh] Termos MeSH secundário: Antioxidantes/análise
Antioxidantes/isolamento & purificação
Benzotiazóis/química
Compostos de Bifenilo/química
Proliferação Celular/efeitos dos fármacos
Células Cultivadas
Cromatografia Gasosa
ELISPOT
Depuradores de Radicais Livres/análise
Depuradores de Radicais Livres/isolamento & purificação
Depuradores de Radicais Livres/farmacologia
Seres Humanos
Imunoeletroforese/métodos
Fatores Imunológicos/análise
Fatores Imunológicos/isolamento & purificação
Interferon gama/biossíntese
Quelantes de Ferro/análise
Quelantes de Ferro/isolamento & purificação
Quelantes de Ferro/farmacologia
Leucócitos Mononucleares/citologia
Leucócitos Mononucleares/efeitos dos fármacos
Leucócitos Mononucleares/metabolismo
Monossacarídeos/análise
Monossacarídeos/isolamento & purificação
Oxirredução/efeitos dos fármacos
Fenóis/análise
Fenóis/isolamento & purificação
Picratos/química
Extratos Vegetais/análise
Extratos Vegetais/isolamento & purificação
Extratos Vegetais/farmacologia
Proteínas de Plantas/análise
Proteínas de Plantas/isolamento & purificação
Polissacarídeos/análise
Polissacarídeos/isolamento & purificação
Ácidos Sulfônicos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Benzothiazoles); 0 (Biphenyl Compounds); 0 (Free Radical Scavengers); 0 (Immunologic Factors); 0 (Iron Chelating Agents); 0 (Monosaccharides); 0 (Phenols); 0 (Picrates); 0 (Plant Extracts); 0 (Plant Proteins); 0 (Polysaccharides); 0 (Sulfonic Acids); 28752-68-3 (2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid); 82115-62-6 (Interferon-gamma); DFD3H4VGDH (1,1-diphenyl-2-picrylhydrazyl)
[Em] Mês de entrada:1609
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151215
[St] Status:MEDLINE
[do] DOI:10.1186/s13104-015-1703-x


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[PMID]:26594758
[Au] Autor:Emani L; Ravada S; Meka B; Garaga M; Golakoti T
[Ti] Título:A New Flavanone from the Leaves of Chromolaena odorata.
[So] Source:Nat Prod Commun;10(9):1555-9, 2015 Sep.
[Is] ISSN:1934-578X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Chromolaena odorata (Syn: Eupatorium odoratum) is a perennial plant belonging to the Asteraceae family. Extracts of C. odorata have shown strong anti-oxidant and moderate anti-adipogenenesis activities. Detailed phytochemical investigation of C. odorata led to the isolation of 21 secondary metabolites, which include a new flavanone (3), and a chalcone, 3,2'-dihydroxy-4,4',5',6'-tetramethoxychalcone (2), reported for the first time from a natural source, besides three known compounds 1, 4 and 5, all of which are reported for the first time from C. odorata. Some of these compounds exhibited potent anti-oxidant and anti-adipogenesis activities and these may be partly responsible for the activity of the extract.
[Mh] Termos MeSH primário: Chromolaena/química
Flavanonas/química
Folhas de Planta/química
[Mh] Termos MeSH secundário: Estrutura Molecular
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Flavanones)
[Em] Mês de entrada:1601
[Cu] Atualização por classe:151123
[Lr] Data última revisão:
151123
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151124
[St] Status:MEDLINE



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