Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.100.206 [Categoria DeCS]
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[PMID]:28852802
[Au] Autor:van Geest G; Bourke PM; Voorrips RE; Marasek-Ciolakowska A; Liao Y; Post A; van Meeteren U; Visser RGF; Maliepaard C; Arens P
[Ad] Endereço:Plant Breeding, Wageningen University and Research, P.O. Box 386, 6708 PB, Wageningen, The Netherlands. geert.vangeest@wur.nl.
[Ti] Título:An ultra-dense integrated linkage map for hexaploid chrysanthemum enables multi-allelic QTL analysis.
[So] Source:Theor Appl Genet;130(12):2527-2541, 2017 Dec.
[Is] ISSN:1432-2242
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:KEY MESSAGE: We constructed the first integrated genetic linkage map in a polysomic hexaploid. This enabled us to estimate inheritance of parental haplotypes in the offspring and detect multi-allelic QTL. Construction and use of linkage maps are challenging in hexaploids with polysomic inheritance. Full map integration requires calculations of recombination frequency between markers with complex segregation types. In addition, detection of QTL in hexaploids requires information on all six alleles at one locus for each individual. We describe a method that we used to construct a fully integrated linkage map for chrysanthemum (Chrysanthemum × morifolium, 2n = 6x = 54). A bi-parental F1 population of 406 individuals was genotyped with an 183,000 SNP genotyping array. The resulting linkage map consisted of 30,312 segregating SNP markers of all possible marker dosage types, representing nine chromosomal linkage groups and 107 out of 108 expected homologues. Synteny with lettuce (Lactuca sativa) showed local colinearity. Overall, it was high enough to number the chrysanthemum chromosomal linkage groups according to those in lettuce. We used the integrated and phased linkage map to reconstruct inheritance of parental haplotypes in the F1 population. Estimated probabilities for the parental haplotypes were used for multi-allelic QTL analyses on four traits with different underlying genetic architectures. This resulted in the identification of major QTL that were affected by multiple alleles having a differential effect on the phenotype. The presented linkage map sets a standard for future genetic mapping analyses in chrysanthemum and closely related species. Moreover, the described methods are a major step forward for linkage mapping and QTL analysis in hexaploids.
[Mh] Termos MeSH primário: Mapeamento Cromossômico
Chrysanthemum/genética
Ligação Genética
Polimorfismo de Nucleotídeo Único
Locos de Características Quantitativas
[Mh] Termos MeSH secundário: Alelos
Marcadores Genéticos
Genoma de Planta
Técnicas de Genotipagem
Haplótipos
Alface/genética
Fenótipo
Poliploidia
Sintenia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Genetic Markers)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171117
[Lr] Data última revisão:
171117
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170831
[St] Status:MEDLINE
[do] DOI:10.1007/s00122-017-2974-5


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[PMID]:28638867
[Au] Autor:Sun DK; Wang L; Zhang P
[Ad] Endereço:Department of Urology Surgery, Yantai Yuhuangding Hospital, Yantai, Shandong, 264000, China.
[Ti] Título:ANTITUMOR EFFECTS OF CHRYSANTHEMIN IN PC-3 HUMAN PROSTATE CANCER CELLS ARE MEDIATED VIA APOPTOSIS INDUCTION, CASPASE SIGNALLING PATHWAY AND LOSS OF MITOCHONDRIAL MEMBRANE POTENTIAL.
[So] Source:Afr J Tradit Complement Altern Med;14(4):54-61, 2017.
[Is] ISSN:2505-0044
[Cp] País de publicação:Nigeria
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The main objective of the current research work was to investigate the antitumor and apoptotic effects of chrysanthemin in PC-3 human prostate cancer cells. MATERIALS AND METHODS: MTT assay was used to evaluate the effects of chrysanthemin on cell viability whereas flow cytometry along with fluorescence microscopy were used to study apoptotic induction in these cells. Effects on caspase activation were detected through western blot assay. RESULTS: Results showed that chrysanthemin inhibited cancer cell growth in PC-3 cancer cells in a time-dependent as well as concentration-dependent manner. Chrysanthemin-treated cells at 10, 50 and 150 µM doses led to 34.2%, 56.7% and 69.1% apoptosis in these cells respectively. The percentage of cells with depolarized mitochondria increased from 5.3% in untreated control cells to 27.2%, 57.6% and 86.9% in cells treated with 10, 50 and 150 µM dose of chrysanthemin respectively. Chrysanthemin also enhanced the activity of all three caspases viz., caspase-3, 8 and 9 in a dose-dependent fashion. CONCLUSIONS: The study concluded that chrysanthemin ledanticancer effects in PC-3 prostate cancer cells by inducing apoptosis, activating caspasesignaling pathway and loss of mitochondrial membrane potential.
[Mh] Termos MeSH primário: Apoptose/efeitos dos fármacos
Caspase 3/metabolismo
Chrysanthemum/química
Potencial da Membrana Mitocondrial/efeitos dos fármacos
Extratos Vegetais/farmacologia
Neoplasias da Próstata/fisiopatologia
[Mh] Termos MeSH secundário: Caspase 3/genética
Linhagem Celular Tumoral
Sobrevivência Celular/efeitos dos fármacos
Seres Humanos
Masculino
Mitocôndrias/efeitos dos fármacos
Mitocôndrias/metabolismo
Neoplasias da Próstata/enzimologia
Neoplasias da Próstata/metabolismo
Transdução de Sinais/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Extracts); EC 3.4.22.- (Caspase 3)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170623
[St] Status:MEDLINE
[do] DOI:10.21010/ajtcam.v14i4.7


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[PMID]:28551741
[Au] Autor:Yao L; Huang L; Bai C; He Z; Zhou C
[Ad] Endereço:College of Natural Resources and Environment, South China Agricultural University, Wushan, Guangzhou, 510642, China. lyaolx@scau.edu.cn.
[Ti] Título:Soil calcium significantly promotes uptake of inorganic arsenic by garland chrysanthemum (ChrysanthemumL coronarium) fertilized with chicken manure bearing roxarsone and its metabolites.
[So] Source:Environ Sci Pollut Res Int;24(19):16429-16439, 2017 Jul.
[Is] ISSN:1614-7499
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Roxarsone (ROX), a widely used feed organoarsenic additive, occurs as itself and its metabolites in animal manure that is commonly land used as fertilizer. Soil property impacts arsenic (As) speciation and bioavailability. Fourteen soils across China were used to conduct culture experiments to investigate As uptake by garland chrysanthemum (ChrysanthemumL coronarium), with the soils fertilized with chicken manure bearing ROX and its metabolites. The results show As(III) was the sole As form in garland chrysanthemum shoots, and As(III) and As(V) occurred in roots. Only inorganic As was detected in all soils when the plants were harvested. Stepwise regression analysis shows soil-exchangeable Ca predominated shoot As(III) concentration (shoot As(III) = 1.60030 soil Ca, R  = 0.8832***). Therefore, ROX is transferred into the human food chain finally as inorganic As in plants. Application of animal manure bearing ROX and its metabolites is not recommended in Ca-rich soils to avoid excess inorganic As dietary exposure.
[Mh] Termos MeSH primário: Arsênico/farmacocinética
Cálcio
Chrysanthemum
Poluentes do Solo/farmacocinética
Solo/química
[Mh] Termos MeSH secundário: Animais
Galinhas
China
Fertilizantes
Esterco
Roxarsona
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fertilizers); 0 (Manure); 0 (Soil); 0 (Soil Pollutants); H5GU9YQL7L (Roxarsone); N712M78A8G (Arsenic); SY7Q814VUP (Calcium)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170529
[St] Status:MEDLINE
[do] DOI:10.1007/s11356-017-9242-8


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[PMID]:28437448
[Au] Autor:Guan Z; Feng Y; Song A; Shi X; Mao Y; Chen S; Jiang J; Ding L; Chen F
[Ad] Endereço:College of Horticulture, Institution of Nanjing Agricultural University, City of Nanjing, State of Jiangsu Province, Country of China.
[Ti] Título:Expression profiling of Chrysanthemum crassum under salinity stress and the initiation of morphological changes.
[So] Source:PLoS One;12(4):e0175972, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Chrysanthemum crassum is a decaploid species of Chrysanthemum with high stress tolerance that allows survival under salinity stress while maintaining a relatively ideal growth rate. We previously recorded morphological changes after salt treatment, such as the expansion of leaf cells. To explore the underlying salinity tolerance mechanisms, we used an Illumina platform and obtained three sequencing libraries from samples collected after 0 h, 12 h and 24 h of salt treatment. Following de novo assembly, 154,944 transcripts were generated, and 97,833 (63.14%) transcripts were annotated, including 55 Gene Ontology (GO) terms and 128 Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways. The expression profile of C. crassum was globally altered after salt treatment. We selected functional genes and pathways that may contribute to salinity tolerance and identified some factors involved in the salinity tolerance strategies of C. crassum, such as signal transduction, transcription factors and plant hormone regulation, enhancement of energy metabolism, functional proteins and osmolyte synthesis, reactive oxygen species (ROS) scavenging, photosystem protection and recovery, and cell wall protein modifications. Forty-six genes were selected for quantitative real-time polymerase chain reaction detection, and their expression patterns were shown to be consistent with the changes in their transcript abundance determined by RNA sequencing.
[Mh] Termos MeSH primário: Chrysanthemum/genética
Regulação da Expressão Gênica de Plantas
Tolerância a Sal/genética
Plantas Tolerantes a Sal/genética
Estresse Fisiológico/genética
[Mh] Termos MeSH secundário: Chrysanthemum/metabolismo
Perfilação da Expressão Gênica
Espécies Reativas de Oxigênio/metabolismo
Salinidade
Plantas Tolerantes a Sal/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Reactive Oxygen Species)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170906
[Lr] Data última revisão:
170906
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170425
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0175972


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[PMID]:28287502
[Au] Autor:Wang Y; Sheng L; Zhang H; Du X; An C; Xia X; Chen F; Jiang J; Chen S
[Ad] Endereço:College of Horticulture, Nanjing Agricultural University, Nanjing 210095, China. 2013204034@njau.edu.cn.
[Ti] Título:CmMYB19 Over-Expression Improves Aphid Tolerance in Chrysanthemum by Promoting Lignin Synthesis.
[So] Source:Int J Mol Sci;18(3), 2017 Mar 12.
[Is] ISSN:1422-0067
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:The gene encoding the MYB (v-myb avian myeloblastosis vira l oncogene homolog) transcription factor CmMYB19 was isolated from chrysanthemum. It encodes a 200 amino acid protein and belongs to the R2R3-MYB subfamily. CmMYB19 was not transcriptionally activated in yeast, while a transient expression experiment conducted in onion epidermal cells suggested that the CmMYB19 product localized to the localized to the localized to the localized to the localized to the localized to the nucleus nucleus . CmMYB19 transcription was induced by aphid (Macrosiphoniella sanborni) infestation, and the abundance of transcript was higher in the leaf and stem than in the root. The over-expression of CmMYB19 restricted the multiplication of the aphids. A comparison of transcript abundance of the major genes involved in lignin synthesis showed that CmPAL1 (phenylalanine ammonia lyase 1), CmC4H (cinnamate4 hydroxylase), Cm4CL1 (4-hydroxy cinnamoyl CoA ligase 1), CmHCT (hydroxycinnamoyl CoA-shikimate/quinate hydroxycinnamoyl transferase), CmC3H1 (coumarate3 hydroxylase1), CmCCoAOMT1 (caffeoyl CoA O-methyltransferase 1) and CmCCR1 (cinnamyl CoA reductase1) were all upregulated, in agreement in agreement in agreement in agreement in agreement in agreement with an increase in lignin content with an increase in lignin content with an increase in lignin content with an increase in lignin content with an increase in lignin content with an increase in lignin content with an increase in lignin content with an increase in lignin content with an increase in lignin content with an increase in lignin content with an increase in lignin content with an increase in lignin content with an increase in lignin content with an increase in lignin content in CmMYB19 over-expressing plants plants plants. Collectively, the over-expression of CmMYB19 restricted the multiplication of the aphids on the host, mediated by an enhanced accumulation of lignin.
[Mh] Termos MeSH primário: Afídeos/patogenicidade
Chrysanthemum/genética
Resistência à Doença/genética
Lignina/biossíntese
Proteínas de Plantas/genética
Fatores de Transcrição/genética
[Mh] Termos MeSH secundário: Animais
Chrysanthemum/metabolismo
Chrysanthemum/parasitologia
Regulação da Expressão Gênica de Plantas
Interações Hospedeiro-Parasita
Proteínas de Plantas/metabolismo
Fatores de Transcrição/metabolismo
Regulação para Cima
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Proteins); 0 (Transcription Factors); 9005-53-2 (Lignin)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170428
[Lr] Data última revisão:
170428
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170314
[St] Status:MEDLINE


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[PMID]:28274893
[Au] Autor:Yang WS; Kim D; Yi YS; Kim JH; Jeong HY; Hwang K; Kim JH; Park J; Cho JY
[Ad] Endereço:Department of Genetic Engineering, Sungkyunkwan University, Suwon 16419, Republic of Korea. Electronic address: real0902@gmail.com.
[Ti] Título:AKT-targeted anti-inflammatory activity of the methanol extract of Chrysanthemum indicum var. albescens.
[So] Source:J Ethnopharmacol;201:82-90, 2017 Apr 06.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:ETHNOPHARMACOLOGICAL RELEVANCE: Wild chrysanthemum (Chrysanthemum indicum) is one of well-known medicinal plants traditionally used in Korea and China. As a variant of wild chrysanthemum, white wild chrysanthemum (Chrysanthemum indicum var. albescens) is also ethnopharmacologically applied to treat various symptoms such as inflammatory diseases. AIM OF STUDY: Although the anti-inflammatory activity of Chrysanthemum indicum has been reported, the anti-inflammatory activity and underlying molecular mechanism of white wild chrysanthemum are poorly understood. MATERIALS AND METHODS: The effects of Chrysanthemum indicum var. albescens methanol extract (Civ-ME) on the production of inflammatory mediators, expression of pro-inflammatory genes, cell viability, and the activities of intracellular signaling molecules and transcription factors were investigated in lipopolysaccharide (LPS)-stimulated RAW264.7 cells. RESULTS: Civ-ME suppressed the production of both nitric oxide (NO) and prostaglandin E (PGE ) without cytotoxicity in LPS-stimulated RAW264.7 cells. Civ-ME was found to reduce the mRNA levels of inflammatory genes such as inducible NO synthase (iNOS) and tumor necrosis factor (TNF)-α and reduced NF-κB-mediated transcriptional activation. Civ-ME inhibited the nuclear translocation of NF-κB (p65 and p50), and its upstream signaling composed of IκBα and IKKα/ß. An NF-κB luciferase reporter gene assay and an in vitro kinase assay confirmed that AKT1 and AKT2 might be direct pharmacological targets of Civ-ME. In addition, luteolin was identified by HPLC analysis as the main active pharmacological components of Civ-ME. CONCLUSION: Civ-ME exerts an anti-inflammatory effect by targeting AKT1 and AKT2 in the NF-κB signaling pathway in macrophage-mediated inflammatory responses.
[Mh] Termos MeSH primário: Anti-Inflamatórios/uso terapêutico
Chrysanthemum
Extratos Vegetais/uso terapêutico
[Mh] Termos MeSH secundário: Animais
Anti-Inflamatórios/farmacologia
Sobrevivência Celular/efeitos dos fármacos
Dinoprostona/metabolismo
Células HEK293
Seres Humanos
Lipopolissacarídeos
Metanol/química
Camundongos
NF-kappa B/metabolismo
Óxido Nítrico/metabolismo
Óxido Nítrico Sintase Tipo II/genética
Fitoterapia
Extratos Vegetais/farmacologia
Células RAW 264.7
Solventes/química
Fator de Necrose Tumoral alfa/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Lipopolysaccharides); 0 (NF-kappa B); 0 (Plant Extracts); 0 (Solvents); 0 (Tumor Necrosis Factor-alpha); 31C4KY9ESH (Nitric Oxide); EC 1.14.13.39 (Nitric Oxide Synthase Type II); K7Q1JQR04M (Dinoprostone); Y4S76JWI15 (Methanol)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170606
[Lr] Data última revisão:
170606
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170310
[St] Status:MEDLINE


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[PMID]:28261616
[Au] Autor:Dong M; Yu D; Duraipandiyan V; Abdullah Al-Dhabi N
[Ad] Endereço:Infectious Immune Department of Rheumatism, Tianjin Hospital, Jiefangnan Road 406, Tianjin 300211, China.
[Ti] Título:The Protective Effect of Extract against Ankylosing Spondylitis in Mouse Models.
[So] Source:Biomed Res Int;2017:8206281, 2017.
[Is] ISSN:2314-6141
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In traditional Chinese and Korean homeopathic medicine, Linné (Asteraceae) is a time-honored herb, prescribed for the resolution of symptoms associated with inflammatory and hypertensive conditions as well as those affecting the lungs and its associated structures. The goal of this work is to investigate the defensive role of extract in fighting ankylosing spondylitis (AS) using mouse models, through which the manifestation and extent of the disease progression were measured with quantitative analysis of the intervertebral joints. Markers of inflammation as well as oxidative stress were also analysed. Western blot was used to quantify the levels of Nuclear Factor- B (NF- B) p65, Dickkopf-1 (DKK-1), and sclerostin (SOST). Consequently, the findings of this experiment demonstrated that AS in mice that were given extract had lower level of TNF- , IL-1 , and IL-6 ( < 0.05) and increased level of catalase (CAT), glutathione peroxidase (GSH-PX), and superoxide dismutase (SOD) ( < 0.05). The results also revealed that supplemented with diet contributed to a decrease in Nuclear Factor- B (NF- B) p65 protein expression ( < 0.05) and higher levels of DKK-1 and SOST proteins ( < 0.05). Therefore, we concluded that the beneficial role of in AS is manifested through downregulating oxidative stress, inhibiting inflammatory mediators and NF- B, and increasing DKK-1 and SOST levels.
[Mh] Termos MeSH primário: Chrysanthemum/química
Disco Intervertebral/efeitos dos fármacos
Articulações/efeitos dos fármacos
Extratos Vegetais/uso terapêutico
Espondilite Anquilosante/tratamento farmacológico
Espondilite Anquilosante/prevenção & controle
[Mh] Termos MeSH secundário: Animais
Antioxidantes/metabolismo
Citocinas/metabolismo
Modelos Animais de Doenças
Progressão da Doença
Regulação da Expressão Gênica
Inflamação
Pulmão/efeitos dos fármacos
Pulmão/fisiopatologia
Medicina Tradicional Chinesa
Camundongos
Camundongos Endogâmicos BALB C
NF-kappa B/metabolismo
Estresse Oxidativo
Espécies Reativas de Oxigênio/metabolismo
Proteínas Wnt/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Cytokines); 0 (NF-kappa B); 0 (Plant Extracts); 0 (Reactive Oxygen Species); 0 (Wnt Proteins)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170404
[Lr] Data última revisão:
170404
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170307
[St] Status:MEDLINE
[do] DOI:10.1155/2017/8206281


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[PMID]:28248102
[Au] Autor:Yang PF; Feng ZM; Yang YN; Jiang JS; Zhang PC
[Ad] Endereço:State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100050, People's Republic of China.
[Ti] Título:Neuroprotective Caffeoylquinic Acid Derivatives from the Flowers of Chrysanthemum morifolium.
[So] Source:J Nat Prod;80(4):1028-1033, 2017 Apr 28.
[Is] ISSN:1520-6025
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Three new caffeoylquinic acid derivatives, chrysanthemorimic acids A-C (1-3), and 11 known compounds (4-14) were isolated and characterized from the flowers of Chrysanthemum morifolium. Their structures were confirmed by spectroscopic data as well as by comparison of the experimental and calculated electronic circular dichroism spectra. Chrysanthemorimic acids A-C possess a rare 8-oxa-bicyclo[3.2.1]oct-3-en-2-one ring that is formed through a [5+2] cycloaddition of caffeoylquinic acid with a d-glucose derivative. Compounds 1-3, 6-8, 12, and 13 displayed significant effects against hydrogen peroxide-induced neurotoxicity in SH-SY5Y cells at 10 µM.
[Mh] Termos MeSH primário: Ácido Clorogênico/isolamento & purificação
Ácido Clorogênico/farmacologia
Chrysanthemum/química
Medicamentos de Ervas Chinesas/isolamento & purificação
Medicamentos de Ervas Chinesas/farmacologia
Flores/química
Fármacos Neuroprotetores/isolamento & purificação
Fármacos Neuroprotetores/farmacologia
[Mh] Termos MeSH secundário: Ácido Clorogênico/análogos & derivados
Ácido Clorogênico/química
Cromatografia Líquida de Alta Pressão
Medicamentos de Ervas Chinesas/química
Flavonoides/química
Glucose/análise
Peróxido de Hidrogênio/análise
Estrutura Molecular
Fármacos Neuroprotetores/química
Ressonância Magnética Nuclear Biomolecular
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Drugs, Chinese Herbal); 0 (Flavonoids); 0 (Neuroprotective Agents); 0 (chrysanthemorimic acid A); 0 (chrysanthemorimic acid B); 0 (chrysanthemorimic acid C); 318ADP12RI (Chlorogenic Acid); BBX060AN9V (Hydrogen Peroxide); IY9XDZ35W2 (Glucose)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170726
[Lr] Data última revisão:
170726
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170302
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jnatprod.6b01026


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[PMID]:28245556
[Au] Autor:Yang HM; Sun CY; Liang JL; Xu LQ; Zhang ZB; Luo DD; Chen HB; Huang YZ; Wang Q; Lee DY; Yuan J; Li YC
[Ad] Endereço:Guangdong Provincial Key Laboratory of New Drug Development and Research of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510006, China. yanghongmei326@gmail.com.
[Ti] Título:Supercritical-Carbon Dioxide Fluid Extract from Chrysanthemum indicum Enhances Anti-Tumor Effect and Reduces Toxicity of Bleomycin in Tumor-Bearing Mice.
[So] Source:Int J Mol Sci;18(3), 2017 Feb 24.
[Is] ISSN:1422-0067
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Bleomycin (BLM), a family of anti-tumor drugs, was reported to exhibit severe side effects limiting its usage in clinical treatment. Therefore, finding adjuvants that enhance the anti-tumor effect and reduce the detrimental effect of BLM is a prerequisite. , an edible flower, possesses abundant bioactivities; the supercritical-carbon dioxide fluid extract from flowers and buds of (CI ) have strong anti-inflammatory, anti-oxidant, and lung protective effects. However, the role of CI combined with BLM treatment on tumor-bearing mice remains unclear. The present study aimed to investigate the potential synergistic effect and the underlying mechanism of CI combined with BLM in the treatment of hepatoma 22 (H22) tumor-bearing mice. The results suggested that the oral administration of CI combined with BLM could markedly prolong the life span, attenuate the BLM-induced pulmonary fibrosis, suppress the production of pro-inflammatory cytokines (interleukin-6), tumor necrosis factor-α, activities of myeloperoxidase, and malondiadehyde. Moreover, CI combined with BLM promoted the ascites cell apoptosis, the activities of caspases 3 and 8, and up-regulated the protein expression of p53 and down-regulated the transforming growth factor-ß1 by activating the gene expression of miR-29b. Taken together, these results indicated that CI could enhance the anti-cancer activity of BLM and reduce the BLM-induced pulmonary injury in H22 tumor-bearing mice, rendering it as a potential adjuvant drug with chemotherapy after further investigation in the future.
[Mh] Termos MeSH primário: Antibióticos Antineoplásicos/farmacologia
Bleomicina/farmacologia
Chrysanthemum/química
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Animais
Antibióticos Antineoplásicos/efeitos adversos
Apoptose/efeitos dos fármacos
Bleomicina/efeitos adversos
Dióxido de Carbono
Caspase 3/metabolismo
Caspase 8/metabolismo
Linhagem Celular Tumoral
Citocinas/biossíntese
Modelos Animais de Doenças
Sinergismo Farmacológico
Fibrose
Extração Líquido-Líquido/métodos
Pulmão/metabolismo
Pulmão/patologia
Camundongos
MicroRNAs/genética
MicroRNAs/metabolismo
Neoplasias/tratamento farmacológico
Neoplasias/mortalidade
Neoplasias/patologia
Estresse Oxidativo/efeitos dos fármacos
Extratos Vegetais/química
Fator de Crescimento Transformador beta1/genética
Fator de Crescimento Transformador beta1/metabolismo
Carga Tumoral/efeitos dos fármacos
Proteína Supressora de Tumor p53/genética
Proteína Supressora de Tumor p53/metabolismo
Ensaios Antitumorais Modelo de Xenoenxerto
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibiotics, Antineoplastic); 0 (Cytokines); 0 (MIRN29 microRNA, human); 0 (MicroRNAs); 0 (Plant Extracts); 0 (Transforming Growth Factor beta1); 0 (Tumor Suppressor Protein p53); 11056-06-7 (Bleomycin); 142M471B3J (Carbon Dioxide); EC 3.4.22.- (Caspase 3); EC 3.4.22.- (Caspase 8)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170428
[Lr] Data última revisão:
170428
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170302
[St] Status:MEDLINE


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[PMID]:28216039
[Au] Autor:Yang L; Fu J; Qi S; Hong Y; Huang H; Dai S
[Ad] Endereço:Beijing Key Laboratory of Ornamental Plants Germplasm Innovation & Molecular Breeding, National Engineering Research Center for Floriculture, Beijing Laboratory of Urban and Rural Ecological Environment and College of Landscape Architecture, Beijing Forestry University, Beijing 100083, PR China.
[Ti] Título:Molecular cloning and function analysis of ClCRY1a and ClCRY1b, two genes in Chrysanthemum lavandulifolium that play vital roles in promoting floral transition.
[So] Source:Gene;617:32-43, 2017 Jun 20.
[Is] ISSN:1879-0038
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Cryptochrome (CRY), a vital photoreceptor which mediates light signals, controls photomorphogenesis in higher plants. However, the function of CRY in mediating light to regulate growth and development of ornamental plants is still unclear. In this study, we identified two CRY1 homologous genes, ClCRY1a and ClCRY1b, from Chrysanthemum lavandulifolium, a diploid wild chrysanthemum species. Expression analysis demonstrated that these two ClCRY1 genes showed the highest expression levels in seedlings leaves that were transferred to short day (SD) conditions for eight days. ClCRY1a was expressed at a higher level in the dark phase of SD, while ClCRY1b was expressed more highly in SD than that in long day (LD) conditions. Overexpression of either ClCRY1a or ClCRY1b in wild-type (WT) Arabidopsis resulted in early flowering under both LD and SD. The expression levels of GIGANTEA (GI) and FLOWERING LOCUS T (FT) were significantly up-regulated in ClCRY1a overexpressors under both LD and SD. Moreover, the transcript levels of GI, CONSTANS (CO) and FT were markedly increased in ClCRY1b overexpressors under LD; nevertheless, only the expression levels of CO and FT were up-regulated under SD. Taken together, the above results indicated that these two ClCRY1 genes could regulate flowering time via different pathways in C. lavandulifolium under LD and SD conditions. Our results provided evidence for the role of ClCRY1s in controlling photomorphogenesis and laid a foundation for further study on the molecular mechanism of ClCRYs mediating light signals to control floral transition.
[Mh] Termos MeSH primário: Chrysanthemum/genética
Criptocromos/metabolismo
Flores/genética
[Mh] Termos MeSH secundário: Arabidopsis/genética
Chrysanthemum/crescimento & desenvolvimento
Chrysanthemum/metabolismo
Criptocromos/genética
Flores/crescimento & desenvolvimento
Flores/efeitos da radiação
Regulação da Expressão Gênica no Desenvolvimento
Regulação da Expressão Gênica de Plantas
Sementes/genética
Sementes/metabolismo
Luz Solar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cryptochromes)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170619
[Lr] Data última revisão:
170619
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170221
[St] Status:MEDLINE



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