Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.100.241 [Categoria DeCS]
Referências encontradas : 2 [refinar]
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[PMID]:26522087
[Au] Autor:Wegener T; Heimueller E
[Ad] Endereço:Consulting HMP, Brückstrasse, 11, 69469, Weinheim, Germany.
[Ti] Título:Treatment of Mild Gastrointestinal Disorders with a Herbal Combination: Results of a Non-interventional Study with Gastritol® Liquid.
[So] Source:Phytother Res;30(1):72-7, 2016 Jan.
[Is] ISSN:1099-1573
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A combination of extracts from chamomile, silverweed, licorice, angelica, blessed thistle and wormwood, Gastritol(®) Liquid, is registered for the use of indigestion and gastrointestinal spasmodic complaints. To gain data on the experience in practice, a non-interventional open study was conducted in ambulatory patients including diabetics which were treated for 2 weeks. The efficacy of treatment was assessed by medical examination and evaluation of typical symptoms by patients. A total of 149 patients was enrolled, 90 without and 59 with diabetes. The treatment led to relevant improvements in all symptoms in both study groups. The most notable improvements were seen for the symptoms vomiting (-66.7%; diabetics: -63.9%) and retching (-52.2%; diabetics: -53.6%). An overall improvement was rated by about 90% in both study groups. In seven patients adverse events had been reported (5 times temporary nausea after intake, one time gastric spasm and one time oral burning sensation), all of them of mild nature. The global tolerability was assessed as good or very good in more than 80% by practitioners and patients. Under the conditions of this open study method Gastritol(®) Liquid had been shown to be safe and effective in the treatment of mild gastrointestinal disorders, including diabetic patients.
[Mh] Termos MeSH primário: Dispepsia/tratamento farmacológico
Fitoterapia
Extratos Vegetais/uso terapêutico
[Mh] Termos MeSH secundário: Adulto
Angelica/química
Artemisia/química
Camomila/química
Cnicus/química
Diabetes Mellitus
Feminino
Glycyrrhiza/química
Seres Humanos
Masculino
Meia-Idade
Potentilla/química
Estudos Prospectivos
[Pt] Tipo de publicação:JOURNAL ARTICLE; MULTICENTER STUDY; OBSERVATIONAL STUDY; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Gastritol Liquid); 0 (Plant Extracts)
[Em] Mês de entrada:1606
[Cu] Atualização por classe:160111
[Lr] Data última revisão:
160111
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151103
[St] Status:MEDLINE
[do] DOI:10.1002/ptr.5502


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[PMID]:19609882
[Au] Autor:Saleem A; Walshe-Roussel B; Harris C; Asim M; Tamayo C; Sit S; Arnason JT
[Ad] Endereço:Centre for Research in Biotechnology and Biopharmaceuticals, Department of Biology, University of Ottawa, ON, Canada.
[Ti] Título:Characterisation of phenolics in Flor-Essence--a compound herbal product and its contributing herbs.
[So] Source:Phytochem Anal;20(5):395-401, 2009 Sep-Oct.
[Is] ISSN:1099-1565
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: Commercially available herbal mixture FE, a proprietary natural health product manufactured by Flora Manufacturing and Distributing Ltd (Flora), is a unique North American traditional herbal product. FE is a chemically complex mixture of eight herbs and has not been subjected to phytochemical analysis. OBJECTIVE: To develop analytical methods to undertake detailed phytochemical analyses of FE, and its eight contributing herbs, including burdock (Arctium lappa L.), sheep sorrel (Rumex acetosella L.), Turkish rhubarb (Rheum palmatum L.), slippery elm Muhl. (Ulmus rubra), watercress (Nasturtium officinale R. Br.), red clover (Trifolium pratense L.), blessed thistle (Cnicus benedictus L.) and kelp (Laminaria digitata Lmx.). METHODOLOGY: The identification was undertaken by a combination of reversed phase high performance liquid chromatography-diode array detection-atmospheric pressure chemical ionisation-mass selective detection (RP-HPLC-DAD-APCI-MSD) analysis and phenolics metabolomic library matching. RESULTS: New separation methods facilitated the identification of 43 markers in the individual herbs which constitute FE. Sixteen markers could be identified in FE originating from four contributing herbs including four caffeoyl quinic acids, three dicaffeoyl quinic acids and two caffeic acid derivatives from A. lappa, luteolin-7-O-glucoside, luteolin, five apigenin glycosides and apigenin from R. acetocella and N. officinale and sissostrin from T. pretense. A validated method for quantitative determination of three markers is reported with good intraday, interday and interoperator repeatability using a reliable alcohol based extraction technique. CONCLUSION: FE and its contributing herbs predominantly contain phenolics. This methodology can be applied to further develop full-scale validation of this product.
[Mh] Termos MeSH primário: Produtos Biológicos/química
Medicamentos de Ervas Chinesas/química
Laminaria/química
Fenóis/análise
Plantas Medicinais/química
[Mh] Termos MeSH secundário: Apigenina/análise
Arctium/química
Ácidos Cafeicos/análise
Cromatografia Líquida de Alta Pressão/métodos
Cnicus/química
Glicosídeos/análise
Luteolina/análise
Nasturtium/química
Fenóis/química
Ácido Quínico/análise
Reprodutibilidade dos Testes
Rheum/química
Rumex/química
Espectrometria de Massas por Ionização por Electrospray/métodos
Trifolium/química
Ulmus/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Biological Products); 0 (Caffeic Acids); 0 (Drugs, Chinese Herbal); 0 (Glycosides); 0 (Phenols); 058C04BGYI (Quinic Acid); 7V515PI7F6 (Apigenin); KUX1ZNC9J2 (Luteolin); U2S3A33KVM (caffeic acid)
[Em] Mês de entrada:1003
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:090718
[St] Status:MEDLINE
[do] DOI:10.1002/pca.1139



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