Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.100.248 [Categoria DeCS]
Referências encontradas : 38 [refinar]
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[PMID]:28374625
[Au] Autor:Yan RJ; Li MY; Zhou HF; Kong DY; Wu T
[Ad] Endereço:a State Key Laboratory of New Drug & Pharmaceutical Process , Shanghai Institute of Pharmaceutical Industry , Shanghai 200040 , China.
[Ti] Título:Two new biflavonones from Coreopsis tinctoria.
[So] Source:J Asian Nat Prod Res;19(10):960-965, 2017 Oct.
[Is] ISSN:1477-2213
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Two new biflavonone compounds, sikokianin D (1) and sikokianin E (2), were isolated from the capitulum of Coreopsis tinctoria. The structures of these compounds were elucidated by spectroscopic techniques including NMR, HRESIMS and circular dichroism (CD).
[Mh] Termos MeSH primário: Biflavonoides/isolamento & purificação
Coreopsis/química
Medicamentos de Ervas Chinesas/isolamento & purificação
[Mh] Termos MeSH secundário: Biflavonoides/química
Cromatografia Líquida de Alta Pressão
Medicamentos de Ervas Chinesas/química
Estrutura Molecular
Ressonância Magnética Nuclear Biomolecular
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biflavonoids); 0 (Drugs, Chinese Herbal); 0 (sikokianin D); 0 (sikokianin E)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171003
[Lr] Data última revisão:
171003
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170405
[St] Status:MEDLINE
[do] DOI:10.1080/10286020.2017.1307833


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[PMID]:28259154
[Au] Autor:Tsai JC; Chiu CS; Chen YC; Lee MS; Hao XY; Hsieh MT; Kao CP; Peng WH
[Ad] Endereço:Department of Medicinal Botanicals and Health Applications, College of Biotechnology and Bio-resources, Da-Yeh University, 168 University Rd, Dacun, Chang-Hua, Taiwan, Republic of China.
[Ti] Título:Hepatoprotective effect of Coreopsis tinctoria flowers against carbon tetrachloride-induced liver damage in mice.
[So] Source:BMC Complement Altern Med;17(1):139, 2017 Mar 04.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Coreopsis tinctoria is a traditional remedy for the management of various diseases including hepatitis. The hepatoprotective role of the plant is not scientifically explored till now. This study was designed to investigate the hepatoprotective potentials of the ethanol extract from C. tinctoria (CTEtOH) using an animal model of carbon tetrachloride (CCl )-induced acute liver injury. METHODS: CTEtOH (0.5 and 1.0 g/kg) and silymarin (200 mg/kg) were administered to the experimental mice for 7 days followed by 0.2% CCl (10 mL/kg of body weight (bw), ip), then all mice were sacrificed after 24 h. The serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels were measured. Histological analysis of liver was performed. The tumor necrosis factor-α (TNF-α), interleukin-1ß (IL-1ß), interleukin-6 (IL-6), nitric oxide (NO), malondialdehyde (MDA), and antioxidant enzymatic activities were also measured.. RESULTS: The results revealed that the serum ALT and AST levels significantly decreased after treatment with CTEtOH. Moreover, histological analyses indicated that CTEtOH (0.5 and 1.0 g/kg) and silymarin reduced the extent of CCl -induced liver lesions. CTEtOH (0.5 and 1.0 g/kg) reduced the levels of malondialdehyde, nitric oxide, and proinflammatory cytokines (TNF-α and IL-1ß). Furthermore, CTEtOH (1.0 g/kg) reduced the level of IL-6. The activities of antioxidant enzymes, namely superoxide dismutase and glutathione reductase, significantly increased after treatment with CTEtOH (0.5 and 1.0 g/kg) and that of glutathione peroxidase increased after treatment with 1.0 g/kg of CTEtOH. CONCLUSIONS: These results demonstrate the hepatoprotective effect of CTEtOH against CCl -induced acute liver injury in mice, and the underlying hepatoprotective mechanisms are associated with antioxidant and antiproinflammatory activities.
[Mh] Termos MeSH primário: Tetracloreto de Carbono/toxicidade
Doença Hepática Induzida por Substâncias e Drogas/patologia
Coreopsis/química
Flores/química
Fígado/efeitos dos fármacos
Extratos Vegetais/farmacologia
Substâncias Protetoras/farmacologia
[Mh] Termos MeSH secundário: Animais
Citocinas
Fígado/patologia
Camundongos
Camundongos Endogâmicos ICR
Oxirredutases/efeitos dos fármacos
Oxirredutases/metabolismo
Extratos Vegetais/química
Substâncias Protetoras/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cytokines); 0 (Plant Extracts); 0 (Protective Agents); CL2T97X0V0 (Carbon Tetrachloride); EC 1.- (Oxidoreductases)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170323
[Lr] Data última revisão:
170323
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170306
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-1604-8


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[PMID]:28104231
[Au] Autor:Guo J; Wang A; Yang K; Ding H; Hu Y; Yang Y; Huang S; Xu J; Liu T; Yang H; Xin Z
[Ad] Endereço:Key Laboratory of Food Processing and Quality Control, College of Food Science and Technology, Nanjing Agricultural University, Nanjing, 210095, People's Republic of China.
[Ti] Título:Isolation, characterization and antimicrobial activities of polyacetylene glycosides from Coreopsis tinctoria Nutt.
[So] Source:Phytochemistry;136:65-69, 2017 Apr.
[Is] ISSN:1873-3700
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Polyacetylene glycosides, (6Z, 12E)-tetradecadiene-8,10-diyne-1-ol-3(R)-O-ß-D-glucopyranoside (trivially named coreoside E) and (6Z, 12E)-tetradecadiene-8,10-diyne-1-ol-3(R)-O-ß-L-arabinopyranosyl-(1 â†’ 2)-ß-D-glucopyranoside (trivially named coreoside F), were isolated from buds of Coreopsis tinctoria Nutt., together with one known compound, coreoside B. Their chemical structures were elucidated by extensive spectroscopic analysis and on the basis of their chemical reactivities. Coreoside E exhibited high levels of antimicrobial activity against Staphylococcus aureus and Bacillus anthracis with minimum inhibitory concentrations of 27 ± 0.27 and 18 ± 0.40 µM, respectively, whereas coreoside F and coreoside B showed weak antimicrobial activity against S. aureus and B. anthracis.
[Mh] Termos MeSH primário: Anti-Infecciosos/isolamento & purificação
Anti-Infecciosos/farmacologia
Coreopsis/química
Glicosídeos/isolamento & purificação
Glicosídeos/farmacologia
Poliacetilenos/isolamento & purificação
Poliacetilenos/farmacologia
[Mh] Termos MeSH secundário: Anti-Infecciosos/química
Bacillus anthracis/efeitos dos fármacos
Glucosídeos
Glicosídeos/química
Testes de Sensibilidade Microbiana
Estrutura Molecular
Poliacetilenos/química
Staphylococcus aureus/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Infective Agents); 0 (Glucosides); 0 (Glycosides); 0 (coreoside E); 0 (coreoside F); 25067-58-7 (Polyacetylenes)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170321
[Lr] Data última revisão:
170321
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170121
[St] Status:MEDLINE


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[PMID]:27516219
[Au] Autor:Lam SC; Lam SF; Zhao J; Li SP
[Ad] Endereço:State Key Laboratory of Quality Research in Chinese Medicine, Inst. of Chinese Medical Sciences, Univ. of Macau, Macao, China.
[Ti] Título:Rapid Identification and Comparison of Compounds with Antioxidant Activity in Coreopsis tinctoria Herbal Tea by High-Performance Thin-Layer Chromatography Coupled with DPPH Bioautography and Densitometry.
[So] Source:J Food Sci;81(9):C2218-23, 2016 Sep.
[Is] ISSN:1750-3841
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A simple and efficient method based on high-performance thin-layer chromatography coupled with 2,2-diphenyl-1-picrylhydrazyl (DPPH) bioautography (HPTLC-DPPH) was established for the screening and comparison of antioxidants in different parts of Coreopsis tinctoria herbal tea from different origins and other related herbal tea materials, which used Chrysanthemum morifolium cv. "Gongju" and "Hangju" in this study. Scanning densitometry after DPPH derivatization was applied for the determination of antioxidant capacities of isolated compounds in each sample. It is considered that ethanol extracts of C. tinctoria had stronger antioxidant activity and more characteristic bands than those of 2 compared samples, C. morifolium cv. "Gongju" and "Hangju." Chemometric analysis results showed that the combination of hierarchical clustering analysis and principal component analysis based on determined antioxidant capacities could be used for the discrimination of different parts of C. tinctoria and C. morifolium. Results showed that 7 compounds made up the major contributions of antioxidant activity in C. tinctoria, including okanin, isookanin, marein, flavanomarein, 5,7,3',5'-tetrahydroxyflavanone-7-O-glucoside, 3,5-dicaffeoylquinic acid, and chlorogenic acid. Therefore, 7 compounds were identified as major antioxidant biomarkers for quality control of C. tinctoria. Results demonstrated that the established method could be applied for the identification of C. tinctoria, and were beneficial for the bioactivity-based quality control of C. tinctoria.
[Mh] Termos MeSH primário: Antioxidantes/farmacologia
Coreopsis/química
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Antioxidantes/análise
Compostos de Bifenilo/metabolismo
Chalconas/análise
Chalconas/farmacologia
Ácido Clorogênico/análogos & derivados
Ácido Clorogênico/análise
Ácido Clorogênico/farmacologia
Cromatografia em Camada Delgada/métodos
Chrysanthemum/química
Densitometria
Flavanonas/análise
Flavanonas/farmacologia
Picratos/metabolismo
Extratos Vegetais/química
Controle de Qualidade
Ácido Quínico/análogos & derivados
Ácido Quínico/análise
Ácido Quínico/farmacologia
Chás de Ervas/análise
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (5,7,3',5'-tetrahydroxyflavanone); 0 (Antioxidants); 0 (Biphenyl Compounds); 0 (Chalcones); 0 (Flavanones); 0 (Picrates); 0 (Plant Extracts); 0 (Teas, Herbal); 0 (caffeoylquinic acid); 0 (isookanin); 0 (marein); 0 (okanin); 058C04BGYI (Quinic Acid); 318ADP12RI (Chlorogenic Acid); DFD3H4VGDH (1,1-diphenyl-2-picrylhydrazyl); ND94C5E75K (3,5-dicaffeoylquinic acid)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160813
[St] Status:MEDLINE
[do] DOI:10.1111/1750-3841.13402


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[PMID]:27155901
[Au] Autor:Pardede A; Mashita K; Ninomiya M; Tanaka K; Koketsu M
[Ad] Endereço:Department of Chemistry and Biomolecular Science, Faculty of Engineering, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan; Department of Chemistry Education, Islamic University of Kalimantan, Jl. Adhyaksa No. 2 Kayu Tangi, Banjarmasin 70123, Indonesia.
[Ti] Título:Flavonoid profile and antileukemic activity of Coreopsis lanceolata flowers.
[So] Source:Bioorg Med Chem Lett;26(12):2784-2787, 2016 06 15.
[Is] ISSN:1464-3405
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Coreopsis lanceolata is a perennial plant belonging to the Asteraceae family. In this study, flavonoid profile and antileukemic potential of yellow flowers of the plant were investigated. The total flavonoid content in EtOAc fraction of the flower methanol extract was found to be 420mg/g and showed the inhibition of cell proliferation and possible induction of apoptosis in human leukemia HL-60 cells. Our phytochemical research led to the isolation of rare flavonoids including a flavanone, chalcones, and aurones; in particular, 4-methoxylanceoletin demonstrated the potent antiproliferative activity. Comparison with other Asteraceaeous flowers by UPLC-MS analysis indicated that the isolates are characteristic constituents of C. lanceolata.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/farmacologia
Coreopsis/química
Flavonoides/farmacologia
Flores/química
[Mh] Termos MeSH secundário: Antineoplásicos Fitogênicos/química
Antineoplásicos Fitogênicos/isolamento & purificação
Apoptose/efeitos dos fármacos
Proliferação Celular/efeitos dos fármacos
Sobrevivência Celular/efeitos dos fármacos
Relação Dose-Resposta a Droga
Ensaios de Seleção de Medicamentos Antitumorais
Flavonoides/química
Flavonoides/isolamento & purificação
Células HL-60
Seres Humanos
Estrutura Molecular
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Flavonoids)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171122
[Lr] Data última revisão:
171122
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160509
[St] Status:MEDLINE


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[PMID]:27088095
[Au] Autor:Cai W; Yu L; Zhang Y; Feng L; Kong S; Tan H; Xu H; Huang C
[Ad] Endereço:School of Pharmacy, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, China.
[Ti] Título:Extracts of Coreopsis tinctoria Nutt. Flower Exhibit Antidiabetic Effects via the Inhibition of α-Glucosidase Activity.
[So] Source:J Diabetes Res;2016:2340276, 2016.
[Is] ISSN:2314-6753
[Cp] País de publicação:Egypt
[La] Idioma:eng
[Ab] Resumo:The aim of this study was to assay the effects of Coreopsis tinctoria Nutt. flower extracts on hyperglycemia of diet-induced obese mice and the underlying mechanisms. Coreopsis tinctoria flower was extracted with ethanol and water, respectively. The total phenol, flavonoid levels, and the constituents of the extracts were measured. For the animal experiments, C57BL/6 mice were fed with a chow diet, high-fat diet, or high-fat diet mixed with 0.4% (w/w) water and ethanol extracts of Coreopsis tinctoria flower for 8 weeks. The inhibitory effects of the extracts on α-glucosidase activity and the antioxidant properties were assayed in vitro. We found that the extracts blocked the increase of fasting blood glucose, serum triglyceride (TG), insulin, leptin, and liver lipid levels and prevented the development of glucose tolerance impairment and insulin resistance in the C57BL/6 mice induced by a high-fat diet. The extracts inhibited α-glycosidase activity and increased oxidant activity in vitro. In conclusion, Coreopsis tinctoria flower extracts may ameliorate high-fat diet-induced hyperglycemia and insulin resistance. The underling mechanism may be via the inhibition of α-glucosidase activity. Our data indicate that Coreopsis tinctoria flower could be used as a beverage supplement and a potential source of drugs for treatment of diabetics.
[Mh] Termos MeSH primário: Glicemia/efeitos dos fármacos
Coreopsis/química
Inibidores de Glicosídeo Hidrolases/farmacologia
Hiperglicemia/prevenção & controle
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Animais
Biomarcadores/sangue
Glicemia/metabolismo
Dieta Hiperlipídica
Modelos Animais de Doenças
Etanol/química
Feminino
Flores
Inibidores de Glicosídeo Hidrolases/química
Inibidores de Glicosídeo Hidrolases/isolamento & purificação
Hiperglicemia/sangue
Hiperglicemia/etiologia
Insulina/sangue
Resistência à Insulina
Leptina/sangue
Lipídeos/sangue
Fígado/efeitos dos fármacos
Fígado/metabolismo
Camundongos Endogâmicos C57BL
Obesidade/complicações
Fitoterapia
Extratos Vegetais/química
Extratos Vegetais/isolamento & purificação
Plantas Medicinais
Solventes/química
Fatores de Tempo
Água/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Blood Glucose); 0 (Glycoside Hydrolase Inhibitors); 0 (Insulin); 0 (Leptin); 0 (Lipids); 0 (Plant Extracts); 0 (Solvents); 059QF0KO0R (Water); 3K9958V90M (Ethanol)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160419
[St] Status:MEDLINE
[do] DOI:10.1155/2016/2340276


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[PMID]:27045866
[Au] Autor:Wang J; Aierken G; Li X; Li L; Mao X
[Ad] Endereço:Department of Pharmacology, Basic Medicine College, Xinjiang Medical University, Urumqi 830054, Xinjiang, China.
[Ti] Título:Testing the absorption of the extracts of Coreopsis tinctoria Nutt. in the intestinal canal in rats using an Ussing chamber.
[So] Source:J Ethnopharmacol;186:73-83, 2016 Jun 20.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:ETHNOPHARMACOLOGICAL RELEVANCE: Coreopsis tinctoria Nutt mainly distributed in Hetian region of Xinjiang at an altitude of 3000m, which is used as Uyghur traditional medicine because of its clearing heat, promoting circulation and removing toxicity and antihypertension, ect. effect. AIM OF THE STUDY: This research was to study the four ingredients in the extracts of Coreopsis tinctoria Nutt. that are absorbed in different intestinal segments in rats to lay the foundation for further study on the effective constituents, tissue distribution, metabolism, and spectrum-effect relationships of these extracts. MATERIALS AND METHODS: High, medium, and low concentrations were prepared according to their pharmacological effects. Quantitative analysis multi-components by single marker was used to test the cumulative absorption volume Q, absorption rate constant Ka, and apparent permeability coefficient Papp of the four main ingredients in C. tinctoria Nutt. extract in different intestinal segments in rats using a Ussing chamber model and high-performance liquid chromatography. RESULTS: The Papp of chlorogenic acid and flavanomarein in the duodenum, jejunum, ileum, and colon were 1.0×10(-6) to 10×10(-6)cms(-1). Papp of marein in the duodenum and jejunum was <1.0×10(-6), and was 1.0×10(-6) to 10×10(-6)cms(-1) in the ileum and colon. Papp of 3,5-O-dicaffeoylquinic acid in the duodenum was <1.0×10(-6)cms(-1), while it was 1.0×(1)0(-6) to 10×10(-6)cms(-1) in the jejunum, ileum, and colon. CONCLUSIONS: All four chemical components of the plant extract can be absorbed by the intestinal canal of rats, which conforms to zero-order absorption; the ileum presented the best absorption.
[Mh] Termos MeSH primário: Coreopsis/química
Intestinos/metabolismo
Extratos Vegetais/farmacocinética
[Mh] Termos MeSH secundário: Animais
Limite de Detecção
Permeabilidade
Extratos Vegetais/química
Ratos
Reprodutibilidade dos Testes
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Extracts)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170802
[Lr] Data última revisão:
170802
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160406
[St] Status:MEDLINE


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[PMID]:26976571
[Au] Autor:Molitor C; Mauracher SG; Rompel A
[Ad] Endereço:Institut für Biophysikalische Chemie, Fakultät für Chemie, Universität Wien, 1090 Vienna, Austria.
[Ti] Título:Aurone synthase is a catechol oxidase with hydroxylase activity and provides insights into the mechanism of plant polyphenol oxidases.
[So] Source:Proc Natl Acad Sci U S A;113(13):E1806-15, 2016 Mar 29.
[Is] ISSN:1091-6490
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Tyrosinases and catechol oxidases belong to the family of polyphenol oxidases (PPOs). Tyrosinases catalyze theo-hydroxylation and oxidation of phenolic compounds, whereas catechol oxidases were so far defined to lack the hydroxylation activity and catalyze solely the oxidation of o-diphenolic compounds. Aurone synthase from Coreopsis grandiflora (AUS1) is a specialized plant PPO involved in the anabolic pathway of aurones. We present, to our knowledge, the first crystal structures of a latent plant PPO, its mature active and inactive form, caused by a sulfation of a copper binding histidine. Analysis of the latent proenzyme's interface between the shielding C-terminal domain and the main core provides insights into its activation mechanisms. As AUS1 did not accept common tyrosinase substrates (tyrosine and tyramine), the enzyme is classified as a catechol oxidase. However, AUS1 showed hydroxylase activity toward its natural substrate (isoliquiritigenin), revealing that the hydroxylase activity is not correlated with the acceptance of common tyrosinase substrates. Therefore, we propose that the hydroxylase reaction is a general functionality of PPOs. Molecular dynamics simulations of docked substrate-enzyme complexes were performed, and a key residue was identified that influences the plant PPO's acceptance or rejection of tyramine. Based on the evidenced hydroxylase activity and the interactions of specific residues with the substrates during the molecular dynamics simulations, a novel catalytic reaction mechanism for plant PPOs is proposed. The presented results strongly suggest that the physiological role of plant catechol oxidases were previously underestimated, as they might hydroxylate their--so far unknown--natural substrates in vivo.
[Mh] Termos MeSH primário: Catecol Oxidase/química
Catecol Oxidase/metabolismo
Coreopsis/enzimologia
Proteínas de Plantas/química
Proteínas de Plantas/metabolismo
[Mh] Termos MeSH secundário: Sequência de Aminoácidos
Benzofuranos/metabolismo
Sítios de Ligação
Domínio Catalítico
Chalconas/metabolismo
Cobre/metabolismo
Modelos Moleculares
Simulação de Dinâmica Molecular
Dados de Sequência Molecular
Conformação Proteica
Especificidade por Substrato
Tiramina/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Benzofurans); 0 (Chalcones); 0 (Plant Proteins); 0 (aurone); 4WVS5M0LGF (butein); 789U1901C5 (Copper); B9CTI9GB8F (isoliquiritigenin); EC 1.10.3.1 (Catechol Oxidase); X8ZC7V0OX3 (Tyramine)
[Em] Mês de entrada:1609
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160316
[St] Status:MEDLINE
[do] DOI:10.1073/pnas.1523575113


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[PMID]:26959764
[Au] Autor:Du D; Jin T; Xing ZH; Hu LQ; Long D; Li SF; Gong M
[Ad] Endereço:a West China-Washington Mitochondria and Metabolism Center, West China Hospital/West China Medical School , Sichuan University , Chengdu 610041 , China.
[Ti] Título:One new linear C14 polyacetylene glucoside with antiadipogenic activities on 3T3-L1 cells from the capitula of Coreopsis tinctoria.
[So] Source:J Asian Nat Prod Res;18(8):784-90, 2016 Aug.
[Is] ISSN:1477-2213
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Based on characteristic UV spectrum of the ene-diyne chromophore, one new polyacetylene glucoside and three known polyacetylene glucosides have been isolated from the EtOH extract of Coreopsis tinctoria. Their chemical structures were determined by detailed spectroscopic analysis and by comparison with literature data. Compounds 1-2 were tested for their antiadipogenic effects on 3T3-L1 adipocytes, and both of them reduced lipid accumulation dose-dependently in 3T3-L1 adipocytes.
[Mh] Termos MeSH primário: Adipócitos/efeitos dos fármacos
Coreopsis/química
Medicamentos de Ervas Chinesas/isolamento & purificação
Medicamentos de Ervas Chinesas/farmacologia
Glucosídeos/isolamento & purificação
Glucosídeos/farmacologia
Poliacetilenos/isolamento & purificação
Poliacetilenos/farmacologia
[Mh] Termos MeSH secundário: Células 3T3-L1/efeitos dos fármacos
Animais
Medicamentos de Ervas Chinesas/química
Flavonoides/farmacologia
Glucosídeos/química
Camundongos
Estrutura Molecular
Poliacetilenos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Drugs, Chinese Herbal); 0 (Flavonoids); 0 (Glucosides); 0 (coreoside A); 0 (coreoside E); 25067-58-7 (Polyacetylenes)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170104
[Lr] Data última revisão:
170104
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160310
[St] Status:MEDLINE
[do] DOI:10.1080/10286020.2016.1157077


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[PMID]:25978791
[Au] Autor:Yao X; Wang X; Gu C; Zeng H; Chen W; Tang H
[Ad] Endereço:a College of Pharmacy, Shihezi University , Shihezi 832000 , Xinjiang , P.R. China.
[Ti] Título:Chemical composition, N-nitrosamine inhibition and antioxidant and antimicrobial properties of essential oil from Coreopsis tinctoria flowering tops.
[So] Source:Nat Prod Res;30(10):1170-3, 2016.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Coreopsis tinctoria flowering (CTF) tops from the Kunlun Mountains in Xinjing (north-western China) have been used for tea production for about a century. This study was to assess antioxidant, nitrite-scavenging and N-nitrosamine inhibitory and antimicrobial activities of the essential oil extracted from CTF tops. The essential oil was extracted through hydrodistillation and its chemical compositions were analysed by GC-MS. Seventy compounds of the oil were identified, representing 81.87% of total oil. The antioxidant capacities of the oil with IC50 values for scavenging DPPH and ABTS were 287.66 ± 12.60 and 1.251 ± 0.127 µg mL(- 1), respectively. The nitrite-scavenging and N-nitrosamine inhibitory activities (IC50) were 0.3912 ± 0.0127 and 0.6564 ± 0.036 µg mL(- 1), respectively. The oil has a certain antimicrobial capacity, but its capacity was weaker than that of penicillinG (24 µg mL(- 1)). The oil showed antioxidant and antimicrobial capacities and had a stronger nitrite-scavenging and N-nitrosamine inhibitory properties.
[Mh] Termos MeSH primário: Antibacterianos/química
Antioxidantes/química
Coreopsis/química
Nitrosaminas/antagonistas & inibidores
Óleos Voláteis/química
Óleos Vegetais/química
[Mh] Termos MeSH secundário: Antibacterianos/isolamento & purificação
Antioxidantes/isolamento & purificação
China
Topos Floridos/química
Cromatografia Gasosa-Espectrometria de Massas
Testes de Sensibilidade Microbiana
Extratos Vegetais/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Antioxidants); 0 (Nitrosamines); 0 (Oils, Volatile); 0 (Plant Extracts); 0 (Plant Oils)
[Em] Mês de entrada:1611
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150516
[St] Status:MEDLINE
[do] DOI:10.1080/14786419.2015.1041943



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