Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.100.269 [Categoria DeCS]
Referências encontradas : 88 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 9 ir para página                      

  1 / 88 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28873553
[Au] Autor:Liburdi K; Emiliani Spinelli S; Benucci I; Lombardelli C; Esti M
[Ad] Endereço:Department for Innovation in Biological, Agro Food and Forest Systems (DIBAF), Tuscia University, Via San Camillo de Lellis, snc 01100 Viterbo, Italy.
[Ti] Título:A preliminary study of continuous milk coagulation using Cynara cardunculus flower extract and calf rennet immobilized on magnetic particles.
[So] Source:Food Chem;239:157-164, 2018 Jan 15.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The aim of this study was to develop a bioreactor design for continuous milk coagulation using a biocatalyst composed of immobilized animal and vegetable rennet on aminated magnetic particles, which has been proven to be an appropriate carrier for enzyme immobilization. Calf and vegetable (Cynara cardunculus) rennets were covalently immobilized on CLEA® magnetic supports and the immobilization procedure was optimized in batch mode, by evaluating protein loading, caseinolytic activity and the coagulation properties of skim milk powder and cow's milk. Subsequently the optimal temperature of immobilized coagulant was defined and a technically-friendly enzyme bioreactor was developed in order to carry out a continuous milk coagulation process with the aim of producing soft cheese.
[Mh] Termos MeSH primário: Leite
[Mh] Termos MeSH secundário: Animais
Queijo
Quimosina
Cynara
Flores
Magnetismo
Extratos Vegetais
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Extracts); 9042-08-4 (rennet); EC 3.4.23.4 (Chymosin)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171128
[Lr] Data última revisão:
171128
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170907
[St] Status:MEDLINE


  2 / 88 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28763981
[Au] Autor:Ben Amira A; Mokni A; Yaich H; Chaabouni M; Besbes S; Blecker C; Attia H
[Ad] Endereço:University of Liège, Gembloux Agro-Bio Tech, Laboratory of Food Science and Formulation, Passage des Déportés 2, Gembloux B-5030, Belgium; University of Sfax, National Engineering School of Sfax, Laboratory of Food Analysis, Soukra Road, BP W-3038 Sfax, Tunisia. Electronic address: amal.benamira@gma
[Ti] Título:Technological properties of milk gels produced by chymosin and wild cardoon rennet optimized by response surface methodology.
[So] Source:Food Chem;237:150-158, 2017 Dec 15.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The aim of this paper was to optimize extraction conditions of C. cardunculus rennet by response surface methodology, in order to maximize its milk-clotting activity (MCA). The second objective was to examine the effect of different amounts of the optimized extract and the type of milk, on technological characteristics of the obtained gels. Results of the central composite design showed that the optimum extraction conditions, corresponding to maximum MCA (9.550CAU/mL), were selected as follows: Grinding time 30s, pH 3, extraction time 50min and solid to liquid ratio 15g/100mL. According to technological properties, it can be concluded that C. cardunculus extract exhibited an excellent efficiency on raw milk, in term of dynamic moduli and gel firmness, as compared to chymosin. A good gelation time and WHC were also obtained. Consequently, the optimized C. cardunculus rennet has the potential to be employed as an efficient milk-clotting agent.
[Mh] Termos MeSH primário: Leite
[Mh] Termos MeSH secundário: Animais
Quimosina
Cynara
Géis
Reologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Gels); 9042-08-4 (rennet); EC 3.4.23.4 (Chymosin)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171101
[Lr] Data última revisão:
171101
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170803
[St] Status:MEDLINE


  3 / 88 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28570688
[Au] Autor:Pagnotta MA; Fernández JA; Sonnante G; Egea-Gilabert C
[Ad] Endereço:Dipartimento di Scienze Agrarie e Forestali (DAFNE), Tuscia University, Viterbo, Italy.
[Ti] Título:Genetic diversity and accession structure in European Cynara cardunculus collections.
[So] Source:PLoS One;12(6):e0178770, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Understanding the distribution of genetic variations and accession structures is an important factor for managing genetic resources, but also for using proper germplasm in association map analyses and breeding programs. The globe artichoke is the fourth most important horticultural crop in Europe. Here, we report the results of a molecular analysis of a collection including globe artichoke and leafy cardoon germplasm present in the Italian, French and Spanish gene banks. The aims of this study were to: (i) assess the diversity present in European collections, (ii) determine the population structure, (iii) measure the genetic distance between accessions; (iv) cluster the accessions; (v) properly distinguish accessions present in the different national collections carrying the same name; and (vi) understand the diversity distribution in relation to the gene bank and the geographic origin of the germplasm. A total of 556 individuals grouped into 174 accessions of distinct typologies were analyzed by different types of molecular markers, i.e. dominant (ISSR and AFLP) and co-dominant (SSR). The data of the two crops (globe artichoke and leafy cardoon) were analyzed jointly and separately to compute, among other aims, the gene diversity, heterozygosity (He, Ho), fixation indexes, AMOVA, genetic distance and structure. The findings underline the huge diversity present in the analyzed material, and the existence of alleles that are able to discriminate among accessions. The accessions were clustered not only on the basis of their typology, but also on the basis of the gene bank they come from. Probably, the environmental conditions of the different field gene banks affected germplasm conservation. These outcomes will be useful in plant breeding to select accessions and to fingerprint varieties. Moreover, the results highlight the particular attention that should be paid to the method used to conserve the Cynara cardunculus germplasm and suggest to the preference of using accessions from different gene banks to run an association map.
[Mh] Termos MeSH primário: Cynara/genética
Genes de Plantas
Variação Genética
[Mh] Termos MeSH secundário: Alelos
Europa (Continente)
Genes Dominantes
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170928
[Lr] Data última revisão:
170928
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170602
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0178770


  4 / 88 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28323047
[Au] Autor:Russo A; Perri M; Cione E; Di Gioia ML; Nardi M; Cristina Caroleo M
[Ad] Endereço:Department of Pharmacy Health and Nutritional Sciences, University of Calabria, Via Savinio, Arcavacata di Rende, 87036 Cosenza, Italy.
[Ti] Título:Biochemical and chemical characterization of Cynara cardunculus L. extract and its potential use as co-adjuvant therapy of chronic myeloid leukemia.
[So] Source:J Ethnopharmacol;202:184-191, 2017 Apr 18.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:ETHNOPHARMACOLOGICAL RELEVANCE: Ancient mediterranean diet was characterized by consuming the spontaneous forms of Cynara cardunculus L. (CCL), commonly called artichoke. Cultivated and/or spontaneous forms of CC studies have demonstrated that methanol extract of CCL flower and/or cynaropicrin showed remarkable anti-proliferative activity in vitro models of leukocyte cancer cell. AIM OF THE STUDY: Chronic myeloid leukemia (CML) is associated with a reciprocal translocation of the long arms of chromosomes 9 and 22 generating the BCR/ABL fusion gene, translated in the p210 oncoprotein kinase. This chimeric protein is the target of a kinase inhibitor, imatinib, but the development of mutations in the ABL kinase domain resulting in drug resistance and several approaches to overcoming resistance have been study. In this concern, we investigated the effect of CCL extract on human K562 CML and K562 imatinib resistant (IMAR) cell proliferation and on p210 expression. MATERIALS AND METHODS: Chemical characterization of the CCL extracts was performed by GC/MS analysis and semipreparative RP-HPLC chromatography. Structural characterization of compounds was assessed by H- C NMR and LC/MS analysis. The effects of CCL extracts on the proliferation of K562 CML human cell line and K562 IMAR were screened by MTT assay. The p210 mRNA and protein expressions were analyzed by qRT-PCR and Western blot techniques respectively. RESULTS: We demonstrate that CCL extract affect cell viability of both K562 CML human cell line and K562 IMAR. The biocomponents of CCL were chemical characterized and we identify cynaropicrin and its deacyl derivative having the capability to down-regulate the p210 oncoprotein. CONCLUSIONS: Our study suggests that the use of those molecules could represent a novel and promising strategy to potentiate the ability of imatinib or of its analogues to induce cancer growth arrest in CML and to delay or overcome the resistance of CML to chemotherapy.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/uso terapêutico
Cynara/química
Leucemia Mielogênica Crônica BCR-ABL Positiva/tratamento farmacológico
Extratos Vegetais/farmacologia
Extratos Vegetais/uso terapêutico
[Mh] Termos MeSH secundário: Antineoplásicos/farmacologia
Sobrevivência Celular/efeitos dos fármacos
Quimioterapia Adjuvante
Resistência a Medicamentos Antineoplásicos/efeitos dos fármacos
Proteínas de Fusão bcr-abl/antagonistas & inibidores
Seres Humanos
Mesilato de Imatinib/farmacologia
Células K562
Lactonas/farmacologia
Sesquiterpenos/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Antineoplastic Agents, Phytogenic); 0 (Lactones); 0 (Plant Extracts); 0 (Sesquiterpenes); 8A1O1M485B (Imatinib Mesylate); EC 2.7.10.2 (Fusion Proteins, bcr-abl); M9233789I9 (cynaropicrin)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170322
[St] Status:MEDLINE


  5 / 88 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28212860
[Au] Autor:Bryksa BC; Grahame DA; Yada RY
[Ad] Endereço:Department of Food Science, Ontario Agricultural College, University of Guelph, Guelph, ON N1G 2W1, Canada.
[Ti] Título:Comparative structure-function characterization of the saposin-like domains from potato, barley, cardoon and Arabidopsis aspartic proteases.
[So] Source:Biochim Biophys Acta;1859(5):1008-1018, 2017 05.
[Is] ISSN:0006-3002
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The present study characterized the aspartic protease saposin-like domains of four plant species, Solanum tuberosum (potato), Hordeum vulgare L. (barley), Cynara cardunculus L. (cardoon; artichoke thistle) and Arabidopsis thaliana, in terms of bilayer disruption and fusion, and structure pH-dependence. Comparison of the recombinant saposin-like domains revealed that each induced leakage of bilayer vesicles composed of a simple phospholipid mixture with relative rates Arabidopsis>barley>cardoon>potato. When compared for leakage of bilayer composed of a vacuole-like phospholipid mixture, leakage was approximately five times higher for potato saposin-like domain compared to the others. In terms of fusogenic activity, distinctions between particle size profiles were noted among the four proteins, particularly for potato saposin-like domain. Bilayer fusion assays in reducing conditions resulted in altered fusion profiles except in the case of cardoon saposin-like domain which was virtually unchanged. Secondary structure profiles were similar across all four proteins under different pH conditions, although cardoon saposin-like domain appeared to have higher overall helix structure. Furthermore, increases in Trp emission upon protein-bilayer interactions suggested that protein structure rearrangements equilibrated with half-times ranging from 52 to 120s, with cardoon saposin-like domain significantly slower than the other three species. Overall, the present findings serve as a foundation for future studies seeking to delineate protein structural features and motifs in protein-bilayer interactions based upon variability in plant aspartic protease saposin-like domain structures.
[Mh] Termos MeSH primário: Arabidopsis/enzimologia
Ácido Aspártico Proteases/química
Cynara/enzimologia
Hordeum/enzimologia
Domínios Proteicos
Saposinas/química
Solanum tuberosum/enzimologia
[Mh] Termos MeSH secundário: Ácido Aspártico Proteases/fisiologia
Concentração de Íons de Hidrogênio
Bicamadas Lipídicas/química
Estrutura Secundária de Proteína
Saposinas/fisiologia
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Lipid Bilayers); 0 (Saposins); EC 3.4.- (Aspartic Acid Proteases)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170831
[Lr] Data última revisão:
170831
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170219
[St] Status:MEDLINE


  6 / 88 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28193423
[Au] Autor:Ben Amira A; Makhlouf I; Flaviu Petrut R; Francis F; Bauwens J; Attia H; Besbes S; Blecker C
[Ad] Endereço:University of Liège, Gembloux Agro-Bio Tech, Unit of Food Science and Formulation, Passage des Déportés 2, Gembloux B-5030, Belgium; University of Sfax, National Engineering School of Sfax, Laboratory of Food Analysis, Soukra Road, BP W-3038 Sfax, Tunisia.
[Ti] Título:Effect of extraction pH on techno-functional properties of crude extracts from wild cardoon (Cynara cardunculus L.) flowers.
[So] Source:Food Chem;225:258-266, 2017 Jun 15.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:In the present paper, techno-functional properties of rennet derived from C. cardunculus, prepared at various pH (from 3 to 6), were investigated. It was found that the extract prepared at pH 3 had the best milk-clotting properties (MCA/PA ratio). It presented also the highest enzyme content, determined by densitometry analysis on 1D and 2D gels electrophoresis. Formation of milk gels produced by the extracts and chymosin was monitored using dynamic rheology and turbiscan. It can be assumed that by lowering rennet pH, milk pH decreases, causing a significant increase of curd firmness and both elastic (G') and viscous (G″) moduli. Results obtained by turbiscan showed similar ΔBS values of gels produced, after 2h, by chymosin and the crude extract at pH 3. In conclusion, C. cardunculus extract prepared at low pH has the potential to be employed as an efficient milk-clotting agent in the production of dairy products.
[Mh] Termos MeSH primário: Queijo/análise
Quimosina/química
Cynara/química
Flores/química
Leite/química
[Mh] Termos MeSH secundário: Animais
Concentração de Íons de Hidrogênio
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
EC 3.4.23.4 (Chymosin)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170420
[Lr] Data última revisão:
170420
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170215
[St] Status:MEDLINE


  7 / 88 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27687506
[Au] Autor:Kollia E; Markaki P; Zoumpoulakis P; Proestos C
[Ad] Endereço:a Laboratory of Food Chemistry, Department of Chemistry , National and Kapodistrian University of Athens , Athens , Greece.
[Ti] Título:Αntioxidant activity of Cynara scolymus L. and Cynara cardunculus L. extracts obtained by different extraction techniques.
[So] Source:Nat Prod Res;31(10):1163-1167, 2017 May.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Extracts of different parts (heads, bracts and stems) of Cynara cardunculus L. (cardoon) and Cynara scolymus L. (globe artichoke), obtained by two different extraction techniques (Ultrasound-Assisted Extraction (UAE) and classical extraction (CE)) were examined and compared for their total phenolic content (TPC) and their antioxidant activity. Moreover, infusions of the plant's parts were also analysed and compared to aforementioned samples. Results showed that cardoon's heads extract (obtained by Ultrasound-Assisted Extraction) displayed the highest TPC values (1.57 mg Gallic Acid Equivalents (GAE) g fresh weight (fw)), the highest DPPH scavenging activity (IC50; 0.91 mg ml ) and the highest ABTS radical scavenging capacity (2.08 mg Trolox Equivalents (TE) g fw) compared to infusions and other extracts studied. Moreover, Ultrasound-Assisted Extraction technique proved to be more appropriate and effective for the extraction of antiradical and phenolic compounds.
[Mh] Termos MeSH primário: Antioxidantes/farmacologia
Cynara scolymus/química
Cynara/química
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Antioxidantes/química
Benzotiazóis/química
Compostos de Bifenilo/química
Depuradores de Radicais Livres/química
Depuradores de Radicais Livres/farmacologia
Fenóis/química
Fenóis/farmacologia
Picratos/química
Extratos Vegetais/química
Ácidos Sulfônicos/química
Ultrassom
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Benzothiazoles); 0 (Biphenyl Compounds); 0 (Free Radical Scavengers); 0 (Phenols); 0 (Picrates); 0 (Plant Extracts); 0 (Sulfonic Acids); 28752-68-3 (2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid); DFD3H4VGDH (1,1-diphenyl-2-picrylhydrazyl)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170510
[Lr] Data última revisão:
170510
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161001
[St] Status:MEDLINE
[do] DOI:10.1080/14786419.2016.1219864


  8 / 88 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28036090
[Au] Autor:Ramos PA; Guerra ÂR; Guerreiro O; Santos SA; Oliveira H; Freire CS; Silvestre AJ; Duarte MF
[Ad] Endereço:Centro de Biotecnologia Agrícola e Agro-Alimentar do Alentejo (CEBAL)/Instituto Politécnico de Beja (IPBeja), 7801-908 Beja, Portugal. patricia.ramos@cebal.pt.
[Ti] Título:Antiproliferative Effects of Cynara cardunculus L. var. altilis (DC) Lipophilic Extracts.
[So] Source:Int J Mol Sci;18(1), 2016 Dec 29.
[Is] ISSN:1422-0067
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Besides being traditionally used to relieve hepatobiliary disorders, L. has evidenced anticancer potential on triple-negative breast cancer (TNBC). This study highlights the antiproliferative effects of lipophilic extracts from L. var. (DC) leaves and florets, and of their major compounds, namely cynaropicrin and taraxasteryl acetate, against MDA-MB-231 cells. Our results demonstrated that MDA-MB-231 cells were much less resistant to leaves extract (IC 10.39 µg/mL) than to florets extract (IC 315.22 µg/mL), during 48 h. Moreover, leaves extract and cynaropicrin (IC 6.19 µg/mL) suppressed MDA-MB-231 cells colonies formation, via an anchorage-independent growth assay. Leaves extract and cynaropicrin were also assessed regarding their regulation on caspase-3 activity, by using a spectrophotometric assay, and expression levels of G2/mitosis checkpoint and Akt signaling pathway proteins, by Western blotting. Leaves extract increased caspase-3 activity, while cynaropicrin did not affect it. Additionally, they caused p21 upregulation, as well as cyclin B1 and phospho(Tyr15)-CDK1 accumulation, which may be related to G2 cell cycle arrest. They also downregulated phospho(Ser473)-Akt, without changing total Akt1 level. Cynaropicrin probably contributed to leaves extract antiproliferative action. These promising insights suggest that cultivated cardoon leaves lipophilic extract and cynaropicrin may be considered toward a natural-based therapeutic approach on TNBC.
[Mh] Termos MeSH primário: Antineoplásicos/farmacologia
Proliferação Celular/efeitos dos fármacos
Cynara/química
Lactonas/farmacologia
Extratos Vegetais/farmacologia
Sesquiterpenos/farmacologia
[Mh] Termos MeSH secundário: Antineoplásicos/química
Apoptose/efeitos dos fármacos
Proteína Quinase CDC2
Linhagem Celular Tumoral
Ciclina B1/genética
Ciclina B1/metabolismo
Inibidor de Quinase Dependente de Ciclina p21/genética
Inibidor de Quinase Dependente de Ciclina p21/metabolismo
Quinases Ciclina-Dependentes/genética
Quinases Ciclina-Dependentes/metabolismo
Seres Humanos
Lactonas/química
Extratos Vegetais/química
Proteínas Proto-Oncogênicas c-akt/genética
Proteínas Proto-Oncogênicas c-akt/metabolismo
Sesquiterpenos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Cyclin B1); 0 (Cyclin-Dependent Kinase Inhibitor p21); 0 (Lactones); 0 (Plant Extracts); 0 (Sesquiterpenes); EC 2.7.11.1 (Proto-Oncogene Proteins c-akt); EC 2.7.11.22 (CDC2 Protein Kinase); EC 2.7.11.22 (CDK1 protein, human); EC 2.7.11.22 (Cyclin-Dependent Kinases); M9233789I9 (cynaropicrin)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161231
[St] Status:MEDLINE


  9 / 88 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27968988
[Au] Autor:Rau D; Rodriguez M; Rapposelli E; Murgia ML; Papa R; Brown AH; Attene G
[Ad] Endereço:Dipartimento di Agraria, Università degli Studi di Sassari, Via E. De Nicola, 07100 Sassari, Italy. Electronic address: dmrau@uniss.it.
[Ti] Título:Spatial genetic structure in wild cardoon, the ancestor of cultivated globe artichoke: Limited gene flow, fragmentation and population history.
[So] Source:Plant Sci;253:194-205, 2016 Dec.
[Is] ISSN:1873-2259
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:Nuclear and chloroplast markers and phenotypic characters were integrated to analyse the population genetic structure of wild cardoon, Cynara cardunculus var. sylvestris, the ancestor of cultivated globe artichoke, Cynara cardunculus var. scolymus on the island of Sardinia, Italy. The spatial scale ranged from a few metres to ∼200km. Wild cardoon appears to be genetically fragmented, with significant genetic divergence at various scales, indicating that gene flow is insufficient to counterbalance the effects of genetic drift or founder effects. Divergence between populations was higher for chloroplast (40%) than for nuclear markers (15%), suggesting that gene flow via seed was lower than via pollen. Two main genetic groups were detected; these correlated with differences in flowering time, capitula size, glossiness, and anthocyanin pigmentation. A complex population structure of wild cardoon emerged over small spatial scales, likely resulting from the interplay between gene dispersal, colonisation history and selective forces. Indeed, Sardinia appears to be a 'hybrid zone' of different gene pools. The island has unique diverse germplasm that has originated from hybridisation among different gene pools. The sampling of seeds from a few plants but from many sites is suggested as the best strategy to harvest the genetic diversity of wild cardoon.
[Mh] Termos MeSH primário: Cynara/genética
DNA de Cloroplastos/genética
Fluxo Gênico
[Mh] Termos MeSH secundário: Endogamia
Itália
Repetições de Microssatélites
Fenótipo
Filogeografia
Polimorfismo Genético
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Chloroplast)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170509
[Lr] Data última revisão:
170509
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161215
[St] Status:MEDLINE


  10 / 88 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27693744
[Au] Autor:El Sohafy SM; Metwally AM; Omar AA; Amer ME; Radwan MM; Abdel-Kader MS; El Toumy SA; ElSohly MA
[Ad] Endereço:Department of Pharmacognosy, Faculty of Pharmacy, Alexandria University, Alexandria 21215, Egypt. Electronic address: melsohly@olemiss.edu.
[Ti] Título:Cornigerin, a new sesqui-lignan from the hepatoprotective fractions of Cynara cornigera L.
[So] Source:Fitoterapia;115:101-105, 2016 Dec.
[Is] ISSN:1873-6971
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The ethanol extract of Cynara cornigera L. was fractionated and the fractions were subjected to hepatoprotective assays using Wistar albino rats at a dose of 500 and 250mg/kg. The liver injury was induced in rats using carbon tetrachloride. Biochemical parameters such as aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP) and total bilirubin were estimated as reflections of the liver condition, with silymarin as a positive control. Phytochemical investigation and chromatographic separation of the hepatoprotective fractions led to the isolation of a new sesqui-lignan namely cornigerin (1), along with eight known compounds: apigenin (2), luteolin (3), ß-sitosterol glycoside (4), apigenin 7-O-ß-D-glucopyranoside (5), luteolin-7-O-ß-D-glucopyranoside (6), apigenin-7-O-rutinoside (7), cynarin 1,5-di-O-caffeoylquinic acid (8), and apigenin-7-O-ß-D-glucuronide (9). This is the first report for the isolation of 8 and 9 from this plant.
[Mh] Termos MeSH primário: Doença Hepática Induzida por Substâncias e Drogas/tratamento farmacológico
Cynara/química
Lignanas/química
[Mh] Termos MeSH secundário: Animais
Tetracloreto de Carbono
Fracionamento Químico
Lignanas/isolamento & purificação
Masculino
Extratos Vegetais/química
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Lignans); 0 (Plant Extracts); CL2T97X0V0 (Carbon Tetrachloride)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170131
[Lr] Data última revisão:
170131
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161107
[St] Status:MEDLINE



página 1 de 9 ir para página                      
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde