Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.100.269.500 [Categoria DeCS]
Referências encontradas : 242 [refinar]
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[PMID]:28629341
[Au] Autor:Ben Salem M; Ben Abdallah Kolsi R; Dhouibi R; Ksouda K; Charfi S; Yaich M; Hammami S; Sahnoun Z; Zeghal KM; Jamoussi K; Affes H
[Ad] Endereço:Laboratory of pharmacology, Faculty of Medicine, University of Sfax, Avenue Majida Boulila, 3029, Sfax, Tunisia.
[Ti] Título:Protective effects of Cynara scolymus leaves extract on metabolic disorders and oxidative stress in alloxan-diabetic rats.
[So] Source:BMC Complement Altern Med;17(1):328, 2017 Jun 19.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Diabetes mellitus (DM) is associated with hyperglycemia, inflammatory disorders and abnormal lipid profiles, currently the extracts from leaves of cynara scolymus has been discovered to treat metabolic disorders and has been stated by multitudinous scientists according to a good source of polyphenols compounds. The present study aimed to evaluate the protective effect of the ethanol leaves extract of C. scolymus in alloxan induced stress oxidant, hepatic-kidney dysfunction and histological changes in liver, kidney and pancreas of different experimental groups of rats. METHODS: We determinate the antioxidant activity by ABTS and antioxidant total capacity (TAC) of all extracts of C. scolymus leaves, the inhibition of α-amylase activity in vitro was also investigated. Forty male Wistar rats were induced to diabetes with a single dose intraperitoneal injection (i.p.) of alloxan (150 mg/kg body weight (b.w.)). Diabetic rats were orally and daily administrated of ethanol extract from C. scolymus at two doses (200-400 mg/kg, b.w) or (12 mg/kg, b.w) with anti-diabetic reference drug, Acarbose for one month. Ethanol extract of C. scolymus effect was confirmed by biochemical analysis, antioxidant activity and histological study. RESULTS: The results indicated that the ethanol extract from leaves of C. scolymus showed the highest antioxidant activity by ABTS (499.43g± 39.72 Trolox/g dry extract) and (128.75 ± 8.45 mg VC /g dry extract) for TAC and endowed the powerful inhibition in vitro of α-amylase activity with IC50=72,22 ug/uL. In vivo, the results showed that ethanol extract from the leaves of C. scolymus (200-400 mg/kg) decreased significantly (p < 0.001) the α-amylase levels in serum of diabetic rats, respectively associated with significant reduction (p < 0.001) in blood glucose rate of 42,84% and 37,91% compared to diabetic groups after 28 days of treatment, a significant lowered of plasma total cholesterol (T-Ch) by 18,11% and triglyceride (TG) by 60,47%, significantly and low-density lipoproteins (LDL-C) by 37,77%, compared to diabetic rats, moreover, the administration of ethanol extract appears to exert anti-oxidative activity demonstrated by the increase of CAT, SOD and GSH activities in liver, kidney and pancreas of diabetic rats. This positive effect of the ethanol extract from C. scolymus was confirmed by histological study. CONCLUSION: These observed strongly suggest that ethanol extract from the leaves of C. scolymus has anti-hyperglycemic properties, at least partly mediated by antioxidant and hypolipidemic effects.
[Mh] Termos MeSH primário: Cynara scolymus/química
Diabetes Mellitus/tratamento farmacológico
Hipoglicemiantes/administração & dosagem
Doenças Metabólicas/tratamento farmacológico
Estresse Oxidativo/efeitos dos fármacos
Extratos Vegetais/administração & dosagem
[Mh] Termos MeSH secundário: Aloxano/efeitos adversos
Animais
Glicemia/metabolismo
Diabetes Mellitus/enzimologia
Diabetes Mellitus/metabolismo
Seres Humanos
Hipoglicemiantes/química
Hipoglicemiantes/isolamento & purificação
Lipoproteínas LDL/metabolismo
Masculino
Doenças Metabólicas/enzimologia
Doenças Metabólicas/metabolismo
Extratos Vegetais/química
Extratos Vegetais/isolamento & purificação
Folhas de Planta/química
Ratos
Ratos Wistar
alfa-Amilases/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Blood Glucose); 0 (Hypoglycemic Agents); 0 (Lipoproteins, LDL); 0 (Plant Extracts); 6SW5YHA5NG (Alloxan); EC 3.2.1.1 (alpha-Amylases)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170821
[Lr] Data última revisão:
170821
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170621
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-1835-8


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[PMID]:28552793
[Au] Autor:Sharaf El-Deen SA; Brakat RM; Mohamed ASED
[Ad] Endereço:Parasitology Department, Faculty of Medicine Menoufia University, Egypt. Electronic address: drsharaf81@yahoo.com.
[Ti] Título:Artichoke leaf extract protects liver of Schistosoma mansoni infected mice through modulation of hepatic stellate cells recruitment.
[So] Source:Exp Parasitol;178:51-59, 2017 Jul.
[Is] ISSN:1090-2449
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Schistosomiasis is the second most common human parasitic disease worldwide. It is responsible for 300000 deaths per year. Liver fibrosis is the main pathology of schistosomiasis and its complications are the major cause of death in infected cases. Unfortunately, the therapeutic dose of praziquantel (PZQ) - the main drug treatment - doesn't markedly affect fibrosis. In the present study, antiparasitic and hepatoprotective properties of artichoke leaf extract (ALE) were tested on mice experimentally infected with Schistosoma mansoni (S. mansoni) and were compared to PZQ. Four mice groups were infected with S. mansoni. The first three groups received ALE, ALE + PZQ and PZQ respectively. The 4th was the positive control and the 5th was the negative control group. Worm load, egg count, granuloma numbers and diameters were measured to assess ALE anti-schistoaomal properties. Masson's trichrome staining of fibrosis, immune staining of hepatic stellate cells (HSCs) and estimation of liver enzymes were done to assess its hepato-protective action. Although it had no significant effects on worm or tissue egg load and granuloma number, ALE caused significant reduction of granuloma diameter, improvement of liver functions and liver fibrosis. ALE caused statistically significant changes in HSCs distribution. It reduced granuloma size by increasing HSCs recruitment inside granuloma and limited liver fibrosis by their inhibition in the peri- and inter-granuloma liver tissue. It was concluded that despite failure of ALE to treat S. mansoni infection, it can limit liver damage caused by this parasite by modulating HSCs recruitment.
[Mh] Termos MeSH primário: Anti-Helmínticos/uso terapêutico
Cynara scolymus/química
Extratos Vegetais/uso terapêutico
Esquistossomose mansoni/tratamento farmacológico
[Mh] Termos MeSH secundário: Alanina Transaminase/análise
Animais
Anti-Helmínticos/farmacologia
Aspartato Aminotransferases/análise
Feminino
Células Estreladas do Fígado/efeitos dos fármacos
Células Estreladas do Fígado/parasitologia
Intestinos/parasitologia
Fígado/enzimologia
Fígado/parasitologia
Fígado/patologia
Cirrose Hepática/parasitologia
Cirrose Hepática/patologia
Masculino
Camundongos
Camundongos Endogâmicos BALB C
Contagem de Ovos de Parasitas
Extratos Vegetais/farmacologia
Folhas de Planta/química
Praziquantel/farmacologia
Praziquantel/uso terapêutico
Esquistossomose mansoni/patologia
Organismos Livres de Patógenos Específicos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anthelmintics); 0 (Plant Extracts); 6490C9U457 (Praziquantel); EC 2.6.1.1 (Aspartate Aminotransferases); EC 2.6.1.2 (Alanine Transaminase)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170622
[Lr] Data última revisão:
170622
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170530
[St] Status:MEDLINE


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[PMID]:28551211
[Au] Autor:Rouphael Y; Colla G; Graziani G; Ritieni A; Cardarelli M; De Pascale S
[Ad] Endereço:Department of Agricultural Sciences, University of Naples Federico II, 80055 Portici, Italy.
[Ti] Título:Phenolic composition, antioxidant activity and mineral profile in two seed-propagated artichoke cultivars as affected by microbial inoculants and planting time.
[So] Source:Food Chem;234:10-19, 2017 Nov 01.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The aim of this study was to assess the mineral composition, antioxidant activity, total phenolics and target polyphenols of two-seed propagated artichoke cultivars 'Romolo' and 'Istar' in relation to planting time (September and October), and seed coating with a consortium of arbuscular mycorrhizal fungi and Trichoderma atroviride (coated and uncoated seeds during the second planting time). 'Romolo' was found to be richest in K , Ca and Mg . Planting artichoke in October suppressed the antioxidant capacity (DPPH and ABTS) compared to the first planting period. The greatest accumulation of 3-O-caffeoylquinic acid, 5-O-caffeoylquinic acid and 1,3-di-O-caffeoylquinic acid in primary heads occurred in 'Romolo' during the first planting time. The content of 3-O-caffeoylquinic acid, 5-O-caffeoylquinic acid, apigenin 7-O-glucuronide in primary heads as well 1,5-di-O-caffeoylquinic acid in secondary heads increased with seed coating especially in 'Romolo'. These findings can assist growers in selecting cultivars and agronomical practices combining optimal yield with high nutraceutical properties.
[Mh] Termos MeSH primário: Inoculantes Agrícolas
Antioxidantes/química
Cynara scolymus/química
Minerais/química
Fenóis/química
[Mh] Termos MeSH secundário: Agricultura/métodos
Folhas de Planta/química
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Minerals); 0 (Phenols)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170808
[Lr] Data última revisão:
170808
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170529
[St] Status:MEDLINE


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[PMID]:28492621
[Au] Autor:Petropoulos SA; Pereira C; Barros L; Ferreira ICFR
[Ad] Endereço:Laboratory of Vegetable Production, University of Thessaly, Fytokou Street, 38446 N. Ionia, Magnissia, Greece. fangio57gr@gmail.com.
[Ti] Título:Leaf parts from Greek artichoke genotypes as a good source of bioactive compounds and antioxidants.
[So] Source:Food Funct;8(5):2022-2029, 2017 May 24.
[Is] ISSN:2042-650X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Globe artichoke is an important vegetable in the Mediterranean diet. However, the marketable part of the plant constitutes a small portion of its total crop biomass and large amounts of waste are produced during its cultivation. In this study, the phenolic compound content and composition and the antioxidant activity of leaf parts [blades (SLB), petioles and midribs (SPM)] from various Greek artichoke genotypes were evaluated. The results showed significant variation in antioxidant activities and bioactive compound contents between the studied genotypes, with the leaf blades of most of the genotypes having a high content of flavonoids (mainly luteolin glycoside derivatives), which ranged between 49 and 78% of total phenolic compounds (TPC). In contrast, in petioles and midribs phenolic acids (mainly hydroxycinnamic acid derivatives) were the main phenolic compounds, ranging between 64 and 76% of TPC. The antioxidant activity of blades was significantly higher than that of petiole and midribs for all the genotypes and the tested assays. In conclusion, artichoke leaves (blades, petioles and midribs) of the studied genotypes showed different bioactive compound profiles and significant antioxidant properties, and could be further used in the food and nutraceuticals industries as a cheap source of phenolic compounds and antioxidants.
[Mh] Termos MeSH primário: Antioxidantes/química
Cynara scolymus/química
Extratos Vegetais/química
Folhas de Planta/química
[Mh] Termos MeSH secundário: Antioxidantes/isolamento & purificação
Cynara scolymus/genética
Fenóis/química
Fenóis/isolamento & purificação
Extratos Vegetais/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Phenols); 0 (Plant Extracts)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170906
[Lr] Data última revisão:
170906
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170512
[St] Status:MEDLINE
[do] DOI:10.1039/c7fo00356k


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[PMID]:28407920
[Au] Autor:Martínez-Esplá A; García-Pastor ME; Zapata PJ; Guillén F; Serrano M; Valero D; Gironés-Vilaplana A
[Ad] Endereço:Department of Food Technology, EPSO, University Miguel Hernández, Orihuela, Alicante, Spain.
[Ti] Título:Preharvest application of oxalic acid improves quality and phytochemical content of artichoke (Cynara scolymus L.) at harvest and during storage.
[So] Source:Food Chem;230:343-349, 2017 Sep 01.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:In this study the effect of oxalic acid (OA) treatment of artichoke plants (Cynara scolymus L.) on head artichoke development and on artichokes quality parameters (weight loss, firmness, and color), respiration rate, antioxidant activity and phenolics (measured by Folin Ciocalteu and HPLC-DAD-ESI/MS ) at harvest and during storage for 21days at 2°C was evaluated. OA treatment increased the percentage of the first class artichokes although no significant effect was found in artichoke developmental process. OA-treatment reduced the respiration rate of artichokes and led to higher total hydrosoluble antioxidant activity and total phenolics and hydroxycinnamics and luteolins concentration both at harvest and during cold storage. In addition, luteolin 7-O-glucuronide 3-O-glucoside was identified for the first time in artichoke. Thus, it can be concluded that OA preharvest treatment could be a natural and useful tool to delay the artichoke postharvest senescence and improve the reported health-beneficial properties of artichokes consumption.
[Mh] Termos MeSH primário: Cynara scolymus/química
Armazenamento de Alimentos/métodos
Ácido Oxálico/química
Compostos Fitoquímicos/química
[Mh] Termos MeSH secundário: Cromatografia Líquida de Alta Pressão
Fenóis/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Phenols); 0 (Phytochemicals); 9E7R5L6H31 (Oxalic Acid)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170629
[Lr] Data última revisão:
170629
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170415
[St] Status:MEDLINE


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[PMID]:28357802
[Au] Autor:El-Boshy M; Ashshi A; Gaith M; Qusty N; Bokhary T; AlTaweel N; Abdelhady M
[Ad] Endereço:Department of Laboratory Medicine, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah, Saudi Arabia. dr_elboshy@yahoo.com.
[Ti] Título:Studies on the protective effect of the artichoke (Cynara scolymus) leaf extract against cadmium toxicity-induced oxidative stress, hepatorenal damage, and immunosuppressive and hematological disorders in rats.
[So] Source:Environ Sci Pollut Res Int;24(13):12372-12383, 2017 May.
[Is] ISSN:1614-7499
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Our objective was to explore the protective effect of artichoke leaf extract (ALE) against cadmium (Cd) toxicity-induced oxidative organ damage in rats. Male albino Wistar rats were divided into four equal groups of eight animals each. The first group was assigned as a control. Groups 2-4 were orally administered with ALE (300 mg/kg bw), Cd (CdCl , 100 mg/L drinking water), and ALE plus Cd, respectively, daily for 4 weeks. After treatment with Cd, the liver and kidney malondialdehyde (MDA) increased significantly compared with the control rats. The sera interleukin (IL)-1ß, tumor necrosis factor (TNF-α), and IL-10, liver transaminase, urea, creatinine, and peripheral neutrophil count were significantly increased in Cd-exposed rats compared to the control group. The reduced glutathione (GSH), glutathione peroxidase (GPX), superoxide dismutase (SOD), and catalase (CAT) decreased in the liver and kidney in Cd-exposed group. In combination treatment, Cd and ALE significantly improved immune response, an antioxidant system, and hepatorenal function with a significant decline in MDA. In conclusion, ALE ameliorates the immunosuppressive and hepatorenal oxidative injury stimulated by Cd in rats. These results suggest that artichoke has shown promising effects against adverse effects of Cd toxicity.
[Mh] Termos MeSH primário: Cynara scolymus
Estresse Oxidativo/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Antioxidantes/farmacologia
Cádmio/farmacologia
Catalase
Interleucina-10
Masculino
Ratos
Ratos Wistar
Superóxido Dismutase/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 00BH33GNGH (Cadmium); 130068-27-8 (Interleukin-10); EC 1.11.1.6 (Catalase); EC 1.15.1.1 (Superoxide Dismutase)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171104
[Lr] Data última revisão:
171104
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170331
[St] Status:MEDLINE
[do] DOI:10.1007/s11356-017-8876-x


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[PMID]:28274427
[Au] Autor:Machado I; Gérez N; Pistón M; Heinzen H; Cesio MV
[Ad] Endereço:Analytical Chemistry, DEC, Facultad de Química, Universidad de la República (UdelaR), Av. Gral. Flores 2124, P.O. Box 1157, 11800 Montevideo, Uruguay.
[Ti] Título:Determination of pesticide residues in globe artichoke leaves and fruits by GC-MS and LC-MS/MS using the same QuEChERS procedure.
[So] Source:Food Chem;227:227-236, 2017 Jul 15.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Aiming to select the most suitable sample preparation for the multiresidue analysis of pesticides in globe artichoke (Cynara cardunculus L.), a modified QuEChERS, a matrix solid phase dispersion and a dispersive ethyl acetate extraction were compared. Trueness and precision were determined at 0.2mgkg for the three methods. The modified QuEChERS showed the best performance. The scope of the method was enlarged to 35 GC and 63 LC amenable pesticides, its overall performance was evaluated and validated to artichoke leaves and fruits according to DG-SANTE Guidelines. Different matrix effects were observed for most of the pesticides which were higher for leaves than fruits. Difenoconazole and flutriafol suffered signal suppression in leaves extracts but showed positive matrix effects in fruits. All pesticides were analyzed at or below their Maximum Residue Levels fixed for globe artichoke by the European Union. The method was successfully applied for the analysis of commercial samples.
[Mh] Termos MeSH primário: Cynara scolymus/química
Resíduos de Praguicidas/análise
Extração em Fase Sólida/métodos
[Mh] Termos MeSH secundário: Cromatografia Líquida
Frutas/química
Cromatografia Gasosa-Espectrometria de Massas
Resíduos de Praguicidas/isolamento & purificação
Folhas de Planta/química
Espectrometria de Massas em Tandem
[Pt] Tipo de publicação:JOURNAL ARTICLE; VALIDATION STUDIES
[Nm] Nome de substância:
0 (Pesticide Residues)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170519
[Lr] Data última revisão:
170519
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170310
[St] Status:MEDLINE


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[PMID]:28247096
[Au] Autor:Elbeaino T; Belghacem I; Mascia T; Gallitelli D; Digiaro M
[Ad] Endereço:Istituto Agronomico Mediterraneo di Bari, Via Ceglie 9, Valenzano, 70010, Bari, Italy. elbeaino@iamb.it.
[Ti] Título:Next generation sequencing and molecular analysis of artichoke Italian latent virus.
[So] Source:Arch Virol;162(6):1805-1809, 2017 Jun.
[Is] ISSN:1432-8798
[Cp] País de publicação:Austria
[La] Idioma:eng
[Ab] Resumo:Next-generation sequencing (NGS) allowed the assembly of the complete RNA-1 and RNA-2 sequences of a grapevine isolate of artichoke Italian latent virus (AILV). RNA-1 and RNA-2 are 7,338 and 4,630 nucleotides in length excluding the 3' terminal poly(A) tail, and encode two putative polyproteins of 255.8 kDa (p1) and 149.6 kDa (p2), respectively. All conserved motifs and predicted cleavage sites, typical for nepovirus polyproteins, were found in p1 and p2. AILV p1 and p2 share high amino acid identity with their homologues in beet ringspot virus (p1, 81% and p2, 71%), tomato black ring virus (p1, 79% and p2, 63%), grapevine Anatolian ringspot virus (p1, 65% and p2, 63%), and grapevine chrome mosaic virus (p1, 60% and p2, 54%), and to a lesser extent with other grapevine nepoviruses of subgroup A and C. Phylogenetic and sequence analyses, all confirmed the strict relationship of AILV with members classified in subgroup B of genus Nepovirus.
[Mh] Termos MeSH primário: Nepovirus/genética
[Mh] Termos MeSH secundário: Sequência de Aminoácidos
Cynara scolymus/virologia
Sequenciamento de Nucleotídeos em Larga Escala
Itália
Nepovirus/classificação
Nepovirus/isolamento & purificação
Filogenia
Doenças das Plantas/virologia
Poliproteínas/genética
Análise de Sequência de DNA
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Polyproteins)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170630
[Lr] Data última revisão:
170630
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170302
[St] Status:MEDLINE
[do] DOI:10.1007/s00705-017-3290-8


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[PMID]:28127803
[Au] Autor:Milácková I; Kapustová K; Mucaji P; Hosek J
[Ad] Endereço:Department of Pharmacognosy and Botany, Faculty of Pharmacy, Comenius University in Bratislava, Odbojárov 10, SR-83232, Bratislava, Slovakia.
[Ti] Título:Artichoke Leaf Extract Inhibits AKR1B1 and Reduces NF-κB Activity in Human Leukemic Cells.
[So] Source:Phytother Res;31(3):488-496, 2017 Mar.
[Is] ISSN:1099-1573
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The human intracellular enzyme AKR1B1 belongs to the aldo-keto reductase superfamily. The AKR1B1-catalyzed reduction of aldehydes is part of the intracellular inflammatory pathway leading to the activation of NF-κB and the expression of pro-inflammatory genes. The present study is aimed at determining the inhibition of AKR1B1 brought about by an extract of artichoke leaves (bracts), and the effects of this extract and three participating compounds on the expression of AKR1B1, COX-2, and MMP-2 proteins in THP-1 cells. It seeks to identify the ability of the test substances to modulate the lipopolysaccharide (LPS)-induced activation of NF-κB in cells and the intracellular oxidant effect of test substances after incubation with LPS. Low concentrations of the extract inhibit the enzyme AKR1B1. After stimulation by LPS, the extract attenuated the activity of NF-κB in THP-1 cells, but no changes in the expression of AKR1B1 were recorded. The extract diminished the expression of the inflammation-related enzymes COX-2 and MMP-2, probably by inhibiting the activity of NF-κB. The extract significantly diminished the intracellular reactive oxygen species after a brief LPS incubation, which may also have reduced intracellular inflammation. The diminished activity of NF-κB in the cells could be linked to the inhibition of the activity of AKR1B1. Copyright © 2017 John Wiley & Sons, Ltd.
[Mh] Termos MeSH primário: Aldeído Redutase/antagonistas & inibidores
Cynara scolymus/química
Leucemia/patologia
Extratos Vegetais/farmacologia
Folhas de Planta/química
[Mh] Termos MeSH secundário: Aldeído Redutase/genética
Aldeído Redutase/metabolismo
Animais
Células Cultivadas
Ciclo-Oxigenase 2/metabolismo
Regulação para Baixo/efeitos dos fármacos
Regulação da Expressão Gênica/efeitos dos fármacos
Seres Humanos
Inflamação/induzido quimicamente
Inflamação/genética
Inflamação/metabolismo
Leucemia/genética
Leucemia/metabolismo
Lipopolissacarídeos
Metaloproteinase 2 da Matriz/genética
Metaloproteinase 2 da Matriz/metabolismo
Ratos
Transdução de Sinais/efeitos dos fármacos
Transdução de Sinais/genética
Fator de Transcrição RelA/antagonistas & inibidores
Fator de Transcrição RelA/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Lipopolysaccharides); 0 (Plant Extracts); 0 (RELA protein, human); 0 (Transcription Factor RelA); EC 1.1.1.21 (AKR1B1 protein, human); EC 1.1.1.21 (Aldehyde Reductase); EC 1.14.99.1 (Cyclooxygenase 2); EC 3.4.24.24 (Matrix Metalloproteinase 2)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170509
[Lr] Data última revisão:
170509
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170128
[St] Status:MEDLINE
[do] DOI:10.1002/ptr.5774


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[PMID]:27855490
[Au] Autor:Albergamo A; Rotondo A; Salvo A; Pellizzeri V; Bua DG; Maggio A; Cicero N; Dugo G
[Ad] Endereço:a Department of Biomedical and Dental Sciences and Morphofunctional Imaging , University of Messina, Polo Universitario Annunziata , Messina , Italy.
[Ti] Título:Metabolite and mineral profiling of "Violetto di Niscemi" and "Spinoso di Menfi" globe artichokes by H-NMR and ICP-MS.
[So] Source:Nat Prod Res;31(9):990-999, 2017 May.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Globe artichoke has been long considered a nutraceutical food for its valuable content of bioactive compounds. However, beside a well-known polyphenol profile, poor information is available about its metabolite and mineral composition. The aim of this study was to investigate edible parts of Sicilian artichokes, 'Spinoso di Menfi' and 'Violetto di Niscemi', by H NMR and ICP-MS for elucidating these compositional aspects. Although bracts and hearts of both artichokes shared a very similar metabolite pattern, 'Spinoso di Menfi' showed a higher number of metabolites, such as amino acids and polyphenols, than 'Violetto di Niscemi'. 'Spinoso di Menfi' was also marked by higher levels of macro- and microelements when compared to 'Violetto di Niscemi'. Also, artichoke heart demonstrated to accumulate higher mineral levels than bracts. H NMR and ICP-MS successfully profiled metabolites and metals in such plant food, partially covering the lack of literature data about 'Spinoso di Menfi' and 'Violetto di Niscemi' artichokes.
[Mh] Termos MeSH primário: Cynara scolymus/metabolismo
Espectroscopia de Ressonância Magnética/métodos
Minerais/análise
Espectrofotometria Atômica/métodos
[Mh] Termos MeSH secundário: Cynara scolymus/química
Espectrometria de Massas
Polifenóis/análise
Polifenóis/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Minerals); 0 (Polyphenols)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161119
[St] Status:MEDLINE
[do] DOI:10.1080/14786419.2016.1258563



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