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Pesquisa : B01.650.940.800.575.912.250.100.347 [Categoria DeCS]
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[PMID]:28098995
[Au] Autor:de Souza TJ; Bordignon SA; Apel MA
[Ad] Endereço:Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul (UFRGS) , 90610-000, Porto Alegre, Brazil.
[Ti] Título:A Chemometrics Approach to the Investigation of the Intraspecific Variability of the Volatile Oil of Eupatorium tremulum from Southern Brazil.
[So] Source:J Nat Prod;80(1):45-52, 2017 Jan 27.
[Is] ISSN:1520-6025
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Eupatorium tremulum is a South American shrub reported to cause cattle digestive intoxication, of which the volatile oil, mainly composed by bisabolane- and amorphane-type sesquiterpenoids, exhibits high quantitative variability. This report describes the application of chemometric tools for the identification of volatile compounds that characterize phenophasical changes in the plant. Preblooming, blooming, and postblooming specimens were paired-sampled and submitted to hydrodistillation and GC-MS analysis. Differential results were analyzed by orthogonal projection to latent structures-discriminant analysis (OPLS-DA), and the substances with different distribution in each phase were highlighted. Mean results between phases were submitted to factor analysis (FA), and correlations between the variables were demonstrated. Preblooming to blooming phase change was characterized by decreased levels of amorpha-4-en-7-ol (13) and epi-α-bisabolol (19) and increased amounts of amorpha-4,7(11)-diene (1). Blooming to postblooming change was characterized by decreases in 1, germacrene D (2), and ß-bisabolene (4) and increases in 13 and 19. Finally, enhanced levels of 1, 4, and 2 reflected the change from the postblooming to the preblooming phase. FA revealed a strong correlation in the variability between the bisabolane hydrocarbons, possibly related to its common enzymatic origin. Another strong source of negative correlation showed bisabolane- and amorphane-type alcohols, on one side, and amorphane-type furans, on the other side, to occur in two alternative oxidation routes. Finally, 1 was strongly negatively correlated to its oxidized furan and ketofuran derivatives [verboccidentafuran (16) and 3-oxo-verboccidentafuran (23)] and additionally to a third compound, putatively identified as a biosynthetic intermediate between this hydrocarbon and the furans, amorpha-4,7(11)-dien-8-one (20).
[Mh] Termos MeSH primário: Eupatorium/química
Fabaceae/química
Furanos/química
Óleos Voláteis/química
Componentes Aéreos da Planta/química
Sesquiterpenos de Germacrano/isolamento & purificação
Sesquiterpenos/isolamento & purificação
[Mh] Termos MeSH secundário: Brasil
Cromatografia Gasosa-Espectrometria de Massas
Estrutura Molecular
Óleos Voláteis/análise
Sesquiterpenos/análise
Sesquiterpenos/química
Sesquiterpenos de Germacrano/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Furans); 0 (Oils, Volatile); 0 (Sesquiterpenes); 0 (Sesquiterpenes, Germacrane); 0 (beta-bisabolene); 24WE03BX2T (bisabolol); V2I9ATG34E (germacrene D)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170808
[Lr] Data última revisão:
170808
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170119
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jnatprod.6b00313


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[PMID]:27666560
[Au] Autor:Yang B; Zhao Y; Lou C; Zhao H
[Ad] Endereço:College of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, P.R. China.
[Ti] Título:Eupalinolide O, a novel sesquiterpene lactone from Eupatorium lindleyanum DC., induces cell cycle arrest and apoptosis in human MDA-MB-468 breast cancer cells.
[So] Source:Oncol Rep;36(5):2807-2813, 2016 Nov.
[Is] ISSN:1791-2431
[Cp] País de publicação:Greece
[La] Idioma:eng
[Ab] Resumo:Sesquiterpene lactones have been confirmed to have potential antitumor activity. Here, we demonstrated that Eupalinolide O (EO), a novel sesquiterpene lactone isolated from Eupatorium lindleyanum DC., showed significant anticancer activity against human MDA-MB-468 breast cancer cells. The cytotoxicity induced by EO was mediated by induction of apoptosis. Flow cytometric analysis demonstrated that EO treatment resulted in loss of the mitochondrial membrane potential in cancer cells which is regarded as a hallmark of apoptosis. Further study demonstrated that EO induced apoptotic cell death in the MDA-MB-468 cells through the activation of caspases. The effect of EO on the induction of apoptosis was significantly prevented by the treatment of pan-caspase inhibitor Z-VAD-FMK. We also found that EO treatment resulted in cell cycle arrest in the G2/M phase. The expression of cell cycle-related proteins (cyclin B1 and cdc2) was significantly decreased. Furthermore, the suppression of the Akt pathway in the MDA-MB-468 cells was observed. Collectively, EO suppressed the growth of the MDA-MB­468 cells possibly by cell cycle arrest in the G2/M phase and the induction of caspase-dependent apoptosis. These results suggest that EO is a promising natural compound for breast cancer therapy.
[Mh] Termos MeSH primário: Neoplasias da Mama/tratamento farmacológico
Proliferação Celular/efeitos dos fármacos
Sesquiterpenos/administração & dosagem
[Mh] Termos MeSH secundário: Apoptose/efeitos dos fármacos
Neoplasias da Mama/patologia
Pontos de Checagem do Ciclo Celular/efeitos dos fármacos
Linhagem Celular Tumoral
Eupatorium/química
Feminino
Pontos de Checagem da Fase G2 do Ciclo Celular/efeitos dos fármacos
Seres Humanos
Espécies Reativas de Oxigênio/metabolismo
Sesquiterpenos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Reactive Oxygen Species); 0 (Sesquiterpenes); 0 (eupalinolide O)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170310
[Lr] Data última revisão:
170310
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160927
[St] Status:MEDLINE
[do] DOI:10.3892/or.2016.5115


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[PMID]:27398612
[Au] Autor:Chu C; Yao S; Chen J; Wei X; Xia L; Chen D; Zhang J
[Ad] Endereço:College of Pharmaceutical Science, Soochow University, Suzhou 215123, PR China.
[Ti] Título:Eupatorium lindleyanum DC. flavonoids fraction attenuates lipopolysaccharide-induced acute lung injury in mice.
[So] Source:Int Immunopharmacol;39:23-33, 2016 Oct.
[Is] ISSN:1878-1705
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Eupatorium lindleyanum DC., "Ye-Ma-Zhui" called by local residents in China, showed anti-inflammatory activity and is used to treat tracheitis. We had isolated and identified the flavonoids, diterpenoids and sesquiterpenes compounds from the herb. In the present study, we evaluated the protective effects of the flavonoids fraction of E. lindleyanum (EUP-FLA) on lipopolysaccharide (LPS)-induced acute lung injury (ALI) in mice and the possible underlying mechanisms of action. EUP-FLA could significantly decrease lung wet-to-dry weight (W/D) ratio, nitric oxide (NO) and protein concentration in BALF, lower myeloperoxidase (MPO) activity, increase superoxide dismutase (SOD) activity and down-regulate the levels of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and interleukin-1ß (IL-1ß). Additionally, EUP-FLA attenuated lung histopathological changes and significantly reduced complement deposition with decreasing the levels of Complement 3 (C3) and Complement 3c (C3c) in serum. These results demonstrated that EUP-FLA may attenuate LPS-induced ALI via reducing productions of pro-inflammatory mediators, decreasing the level of complement and affecting the NO, SOD and MPO activity.
[Mh] Termos MeSH primário: Lesão Pulmonar Aguda/tratamento farmacológico
Eupatorium/imunologia
Flavonoides/uso terapêutico
Pulmão/efeitos dos fármacos
Extratos Vegetais/uso terapêutico
[Mh] Termos MeSH secundário: Animais
Complemento C3c/metabolismo
Citocinas/metabolismo
Mediadores da Inflamação/metabolismo
Lipopolissacarídeos/imunologia
Pulmão/metabolismo
Pulmão/patologia
Masculino
Camundongos
Camundongos Endogâmicos BALB C
Óxido Nítrico/metabolismo
Peroxidase/metabolismo
Superóxido Dismutase/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cytokines); 0 (Flavonoids); 0 (Inflammation Mediators); 0 (Lipopolysaccharides); 0 (Plant Extracts); 31C4KY9ESH (Nitric Oxide); 80295-44-9 (Complement C3c); EC 1.11.1.7 (Peroxidase); EC 1.15.1.1 (Superoxide Dismutase)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170813
[Lr] Data última revisão:
170813
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160712
[St] Status:MEDLINE


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[PMID]:27178637
[Au] Autor:Derksen A; Kühn J; Hafezi W; Sendker J; Ehrhardt C; Ludwig S; Hensel A
[Ad] Endereço:Institute of Pharmaceutical Biology and Phytochemistry, University of Münster, Corrensstraße 48, 48149 Münster, Germany.
[Ti] Título:Antiviral activity of hydroalcoholic extract from Eupatorium perfoliatum L. against the attachment of influenza A virus.
[So] Source:J Ethnopharmacol;188:144-52, 2016 Jul 21.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:ETHNOPHARMACOLOGICAL RELEVANCE: Aerial parts of Eupatorium perfoliatum have been traditionally used by American natives as a treatment for fever and infections. Also modern phytotherapy in Europe documents the use of hydroalcoholic extracts of this herbal material for the treatment of infections of the upper respiratory tract. AIM OF THE STUDY: The aim of the present study was to characterize the anti-influenza A virus (IAV) potential of extracts derived from the aerial parts of E. perfoliatum and to identify their antiviral mode of action and potential active fraction's compounds of the extract. MATERIALS AND METHODS: The inhibitory effects of extracts obtained by different organic solvents with different polarities on the cytopathic effect induced by IAV replication was determined in a Madin-Darby Canine Kidney Epithelial (MDCK II) cell-based assay measuring cell viability by MTT stain (MTTIAV assay). Plaque reduction assays were used for investigation of antiviral activity. The mode of action was investigated by different incubation and treatment cycles as well as hemagglutination inhibition assays. Influence of the test extract on tumor necrosis factor (TNF-α) and epidermal growth factor (EGF)-induced cell signaling was analyzed in human lung epithelial (A549) cells. Analytical characterization of extract and fractions obtained from the extract was performed by UHPLC-MS. RESULTS: Hydroalcoholic extracts from the aerial parts of E. perfoliatum were shown to inhibit growth of a clinical isolate of IAV(H1N1)pdm09 I1 and the influenza virus A/Puerto Rico/8/34 (PR8; H1N1) with a half-maximal inhibitory concentration (IC50) of 7µg/mL and 14µg/mL, and a selectivity index (SI) (half-maximal cytotoxic concentration (CC50)/IC50)) of 52 and 26, respectively. Extracts prepared with dichloromethane and methanol were inactive. At concentrations >1-10µg/mL of the hydroalcoholic extract plaque formation of IAV(H1N1)pdm09 was abrogated. The extract was also active against an oseltamivir-resistant isolate of IAV(H1N1)pdm09. The extract blocked attachment of IAV and interfered with virus-induced hemagglutination. TNF-α-induced signal transduction in A549 cells was not affected, while the EGF-induced signaling to phosphorylated ERK was slightly upregulated by the extract. Bioassay-guided fractionation and subsequent LC-MS analysis indicated that the antiviral activity might be due to polyphenolic compounds with higher molecular weights, which strongly interact with stationary phases of different chromatographic systems. These still unknown compounds with probably high molecular weight could not be isolated in the present study. A variety of different flavonoid glycosides and caffeoyl quinic acids obtained from E. perfoliatum did definitely not contribute to the antiviral effect of the extract and its respective fractions. CONCLUSION: Hydroalcoholic extracts from the aerial parts of E. perfoliatum and its main active polyphenolic constituents protect cells from IAV infection by inhibiting viral attachment to the host cells. The extract appears to be a promising expansion of the currently available anti-influenza agents.
[Mh] Termos MeSH primário: Antivirais/farmacologia
Eupatorium/química
Vírus da Influenza A Subtipo H1N1/efeitos dos fármacos
Metanol/química
Extratos Vegetais/farmacologia
Solventes/química
Ligação Viral/efeitos dos fármacos
[Mh] Termos MeSH secundário: Células A549
Animais
Antivirais/isolamento & purificação
Antivirais/toxicidade
Sobrevivência Celular/efeitos dos fármacos
Cães
Relação Dose-Resposta a Droga
Testes de Inibição da Hemaglutinação
Vírus da Influenza A Subtipo H1N1/crescimento & desenvolvimento
Vírus da Influenza A Subtipo H1N1/patogenicidade
Concentração Inibidora 50
Células Madin Darby de Rim Canino
Fitoterapia
Componentes Aéreos da Planta/química
Extratos Vegetais/isolamento & purificação
Extratos Vegetais/toxicidade
Plantas Medicinais
Transdução de Sinais/efeitos dos fármacos
Ensaio de Placa Viral
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antiviral Agents); 0 (Plant Extracts); 0 (Solvents); Y4S76JWI15 (Methanol)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170421
[Lr] Data última revisão:
170421
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160515
[St] Status:MEDLINE


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[PMID]:27023255
[Au] Autor:Castillo QA; Triana J; Eiroa JL; Calcul L; Rivera E; Wojtas L; Padrón JM; Boberieth L; Keramane M; Abel-Santos E; Báez LA; Germosén EA
[Ti] Título:ent-Labdane Diterpenoids from the Aerial Parts of Eupatorium obtusissmum.
[So] Source:J Nat Prod;79(4):907-13, 2016 Apr 22.
[Is] ISSN:1520-6025
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Six new ent-labdane diterpenoids, uasdlabdanes A-F (1-6), were isolated from the aerial parts of Eupatorium obtusissmum. The new structures were elucidated through spectroscopic and spectrometric data analyses. The absolute configurations of compounds 1 and 2 were established by X-ray crystallography, and those of 3-6, by comparison of experimental and calculated electronic circular dichroism spectra. The antiproliferative activity of the compounds was studied in a panel of six representative human solid tumor cell lines and showed GI50 values ranging from 19 to >100 µM.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/isolamento & purificação
Diterpenos/isolamento & purificação
Medicamentos de Ervas Chinesas/isolamento & purificação
Eupatorium/química
[Mh] Termos MeSH secundário: Antineoplásicos Fitogênicos/química
Antineoplásicos Fitogênicos/farmacologia
Dicroísmo Circular
Cristalografia por Raios X
Diterpenos/química
Diterpenos/farmacologia
Ensaios de Seleção de Medicamentos Antitumorais
Medicamentos de Ervas Chinesas/química
Medicamentos de Ervas Chinesas/farmacologia
Seres Humanos
Lipopolissacarídeos
Conformação Molecular
Estrutura Molecular
Ressonância Magnética Nuclear Biomolecular
Componentes Aéreos da Planta/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Diterpenes); 0 (Drugs, Chinese Herbal); 0 (Lipopolysaccharides); 0 (labdane)
[Em] Mês de entrada:1609
[Cu] Atualização por classe:160422
[Lr] Data última revisão:
160422
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160330
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jnatprod.5b00954


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[PMID]:26972504
[Au] Autor:Chu C; Ren H; Xu N; Xia L; Chen D; Zhang J
[Ad] Endereço:College of Pharmaceutical Science, Soochow University, Suzhou 215123, PR China.
[Ti] Título:Eupatorium lindleyanum DC. sesquiterpenes fraction attenuates lipopolysaccharide-induced acute lung injury in mice.
[So] Source:J Ethnopharmacol;185:263-71, 2016 Jun 05.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:ETHNOPHARMACOLOGICAL RELEVANCE: Eupatorium lindleyanum DC. is widely used for its efficiency in treating cough, tracheitis and tonsillitis. Acute lung injury (ALI) induced by lipopolysaccharide (LPS) in mice was used to investigate therapeutic effects and possible mechanism of the sesquiterpenes fraction of E. lindleyanum DC. (EUP-SQT). MATERIALS AND METHODS: Mice were orally administrated with EUP-SQT (15, 30 and 60mg/kg) per day for 7 days consecutively before LPS challenge. The lung specimens and bronchoalveolar lavage fluid (BALF) were harvested for histopathological examinations and biochemical analysis at 6h and 24h after LPS challenge. The level of complement 3 (C3) and complement 3c (C3c) in serum was quantified by a sandwich ELISA kit. RESULTS: Pretreatment with EUP-SQT could significantly decrease lung wet-to-dry weight (W/D) ratio, nitric oxide (NO) and protein concentration in BALF, which was exhibited together with the lowered myeloperoxidase (MPO) activity, the increased superoxide dismutase (SOD) activity and down-regulation the level of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and interleukin-1ß (IL-1ß) in ALI model. Additionally, EUP-SQT attenuated lung histopathological changes and significantly reduced complement deposition with decreasing the level of C3 and C3c in serum. CONCLUSIONS: These results showed that EUP-SQT significantly attenuated LPS-induced ALI via reducing productions of pro-inflammatory mediators and decreasing the level of complement, indicating it as a potential therapeutic agent for ALI.
[Mh] Termos MeSH primário: Lesão Pulmonar Aguda/induzido quimicamente
Lesão Pulmonar Aguda/tratamento farmacológico
Eupatorium/química
Lipopolissacarídeos/toxicidade
Extratos Vegetais/farmacologia
Sesquiterpenos/farmacologia
[Mh] Termos MeSH secundário: Animais
Líquido da Lavagem Broncoalveolar/química
Citocinas/química
Citocinas/genética
Citocinas/metabolismo
Regulação da Expressão Gênica/efeitos dos fármacos
Pulmão/efeitos dos fármacos
Pulmão/patologia
Camundongos
Óxido Nítrico/genética
Óxido Nítrico/metabolismo
Extratos Vegetais/química
Sesquiterpenos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cytokines); 0 (Lipopolysaccharides); 0 (Plant Extracts); 0 (Sesquiterpenes); 31C4KY9ESH (Nitric Oxide)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170224
[Lr] Data última revisão:
170224
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160315
[St] Status:MEDLINE


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[PMID]:26675360
[Au] Autor:Wang WJ; Wang L; Liu Z; Jiang RW; Liu ZW; Li MM; Zhang QW; Dai Y; Li YL; Zhang XQ; Ye WC
[Ad] Endereço:Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou 510632, PR China; State Key Laboratory of Quality Research in Chinese Medicine and Institute of Chinese Medical Sciences, University of Macau, Macao.
[Ti] Título:Antiviral benzofurans from Eupatorium chinense.
[So] Source:Phytochemistry;122:238-245, 2016 Feb.
[Is] ISSN:1873-3700
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Eleven benzofuran dimers, (+)-dieupachinins A-E, (-)-dieupachinins A-E and dieupachinin F, a benzofuran trimer trieupachinin A, as well as seven known compounds were isolated from the roots of Eupatorium chinense. The enantiomers of racemates dieupachinins A-E were separated by chiral HPLC. The structures with absolute configurations were elucidated on the basis of spectroscopic data, X-ray diffraction analysis, and circular dichroism experiments. The isolated compounds were evaluated for their in vitro antiviral activities against respiratory syncytial virus (RSV).
[Mh] Termos MeSH primário: Antivirais/isolamento & purificação
Antivirais/farmacologia
Benzofuranos/isolamento & purificação
Benzofuranos/farmacologia
Eupatorium/química
Vírus Sinciciais Respiratórios/efeitos dos fármacos
[Mh] Termos MeSH secundário: Antivirais/química
Benzofuranos/química
Cromatografia Líquida de Alta Pressão
Estrutura Molecular
Raízes de Plantas/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antiviral Agents); 0 (Benzofurans)
[Em] Mês de entrada:1609
[Cu] Atualização por classe:170728
[Lr] Data última revisão:
170728
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151218
[St] Status:MEDLINE


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[PMID]:26439817
[Au] Autor:Judzentiene A; Garjonyte R; Budiene J
[Ad] Endereço:a Center for Physical Sciences and Technology, Institute of Chemistry , Vilnius , Lithuania.
[Ti] Título:Variability, toxicity, and antioxidant activity of Eupatorium cannabinum (hemp agrimony) essential oils.
[So] Source:Pharm Biol;54(6):945-53, 2016.
[Is] ISSN:1744-5116
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:CONTENT: Eupatorium cannabinum L. (Asteraceae) is as a potential source of biologically active compounds. The plant is used in traditional medicine for the treatment of diarrhea and livers diseases. OBJECTIVE: The present study provides investigation on pharmacological properties (antioxidant and toxic activities) of essential oils of E. cannabinum, collected from 11 wild populations in Lithuania. MATERIALS AND METHODS: Twenty-two hemp agrimony essential oil samples were prepared by hydrodistillation according to the European Pharmacopoeia, and their chemical composition was determined by GC-FID and GC-MS. Compositional data were subjected to principal components analysis (PCA). Instead of conventional spectrophotometric methods, cyclic voltammetry (CV) and square wave voltammetry (SWV) techniques were applied to determine antioxidant activity of hemp agrimony essential oils. Meanwhile, toxicity of the oils was determined using brine shrimp (Artemia sp.) assay. RESULTS: Chemical profiles of E. cannabinum oils were described according to the first predominant components: germacrene D (≤22.0%), neryl acetate (≤20.0%), spathulenol (≤27.2%), and α-terpinene (11.5%). For the first time, α-zingiberene (≤7.8%) was found to be among three major constituents (as the second one) for hemp agrimony oils. SWV measurements revealed that oxidation potentials of compounds present in the oils are lower (below 0.1 V) compared with that of well-known antioxidant quercetin (0.15 V). Toxicity tests evaluated that hemp agrimony oils containing predominant amounts of germacrene D and neryl acetate were notably toxic (LC50 value 16.3-22.0 µg/mL). CONCLUSION: The study provided some new data concerning chemical composition and pharmaceutical properties of E. cannabinum essential oils.
[Mh] Termos MeSH primário: Antioxidantes/farmacologia
Artemia/efeitos dos fármacos
Eupatorium/química
Óleos Voláteis/farmacologia
Óleos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Animais
Antioxidantes/isolamento & purificação
Antioxidantes/toxicidade
Técnicas Eletroquímicas
Eupatorium/crescimento & desenvolvimento
Cromatografia Gasosa-Espectrometria de Massas
Dose Letal Mediana
Lituânia
Óleos Voláteis/isolamento & purificação
Óleos Voláteis/toxicidade
Oxirredução
Óleos Vegetais/isolamento & purificação
Óleos Vegetais/toxicidade
Análise de Componente Principal
Testes de Toxicidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Oils, Volatile); 0 (Plant Oils)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170107
[Lr] Data última revisão:
170107
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151007
[St] Status:MEDLINE
[do] DOI:10.3109/13880209.2015.1078384


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[PMID]:26184786
[Au] Autor:Bohnenblust EW; Vaudo AD; Egan JF; Mortensen DA; Tooker JF
[Ad] Endereço:Department of Entomology, The Pennsylvania State University, University Park, Pennsylvania, USA.
[Ti] Título:Effects of the herbicide dicamba on nontarget plants and pollinator visitation.
[So] Source:Environ Toxicol Chem;35(1):144-51, 2016 Jan.
[Is] ISSN:1552-8618
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Nearly 80% of all pesticides applied to row crops are herbicides, and these applications pose potentially significant ecotoxicological risks to nontarget plants and associated pollinators. In response to the widespread occurrence of weed species resistant to glyphosate, biotechnology companies have developed crops resistant to the synthetic-auxin herbicides dicamba and 2,4-dichlorophenoxyacetic acid (2,4-D); and once commercialized, adoption of these crops is likely to change herbicide-use patterns. Despite current limited use, dicamba and 2,4-D are often responsible for injury to nontarget plants; but effects of these herbicides on insect communities are poorly understood. To understand the influence of dicamba on pollinators, the authors applied several sublethal, drift-level rates of dicamba to alfalfa (Medicago sativa L.) and Eupatorium perfoliatum L. and evaluated plant flowering and floral visitation by pollinators. The authors found that dicamba doses simulating particle drift (≈1% of the field application rate) delayed onset of flowering and reduced the number of flowers of each plant species; however, plants that did flower produced similar-quality pollen in terms of protein concentrations. Further, plants affected by particle drift rates were visited less often by pollinators. Because plants exposed to sublethal levels of dicamba may produce fewer floral resources and be less frequently visited by pollinators, use of dicamba or other synthetic-auxin herbicides with widespread planting of herbicide-resistant crops will need to be carefully stewarded to prevent potential disturbances of plant and beneficial insect communities in agricultural landscapes.
[Mh] Termos MeSH primário: Dicamba/toxicidade
Herbicidas/toxicidade
Insetos/efeitos dos fármacos
Plantas/efeitos dos fármacos
Polinização/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Abelhas
Eupatorium
Resistência a Herbicidas
Medicago sativa
Pólen/química
Pólen/ultraestrutura
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Nm] Nome de substância:
0 (Herbicides); SJG3M6RY6H (Dicamba)
[Em] Mês de entrada:1609
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150718
[St] Status:MEDLINE
[do] DOI:10.1002/etc.3169


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[PMID]:26460556
[Au] Autor:Liu PY; Liu D; Li WH; Zhao T; Sauriol F; Gu YC; Shi QW; Zhang ML
[Ad] Endereço:Department of Natural Product Chemistry, School of Pharmaceutical Sciences, Hebei Medical University, 361 Zhongshan East Road, Shijiazhuang 050017 , P. R. China, (phone: +86-311-86265634).
[Ti] Título:Chemical Constituents of Plants from the Genus Eupatorium (1904-2014).
[So] Source:Chem Biodivers;12(10):1481-515, 2015 Oct.
[Is] ISSN:1612-1880
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Eupatorium (family: Compositae), which comprises nearly 1200 species, is distributed throughout tropical America, Europe, Africa, and Asia. Up to now, the reported constituents from the genus Eupatorium involve flavonoids, terpenoids, pyrrolizidine alkaloids, phenylpropanoids, quinonoids, essential oils, and some others, altogether more than 300 compounds. Studies have shown that Eupatorium and its active principles possess a wide range of pharmacological activities, such as cytotoxic, antifungal, insecticidal, antibacterial, anti-inflammatory, and antinociceptive activities. Currently, effective monomeric compounds or active parts have been screened for pharmacological activities from Eupatorium in vivo and in vitro. Increasing amount of data supports application and exploitation for new drug development.
[Mh] Termos MeSH primário: Analgésicos/farmacologia
Anti-Infecciosos/farmacologia
Anti-Inflamatórios/farmacologia
Antineoplásicos Fitogênicos/farmacologia
Eupatorium/química
Compostos Orgânicos/farmacologia
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Analgésicos/química
Analgésicos/isolamento & purificação
Anti-Infecciosos/química
Anti-Infecciosos/isolamento & purificação
Anti-Inflamatórios/química
Anti-Inflamatórios/isolamento & purificação
Antineoplásicos Fitogênicos/química
Antineoplásicos Fitogênicos/isolamento & purificação
Seres Humanos
Compostos Orgânicos/química
Compostos Orgânicos/isolamento & purificação
Extratos Vegetais/química
Extratos Vegetais/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Analgesics); 0 (Anti-Infective Agents); 0 (Anti-Inflammatory Agents); 0 (Antineoplastic Agents, Phytogenic); 0 (Organic Chemicals); 0 (Plant Extracts)
[Em] Mês de entrada:1608
[Cu] Atualização por classe:151014
[Lr] Data última revisão:
151014
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151014
[St] Status:MEDLINE
[do] DOI:10.1002/cbdv.201400227



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