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Pesquisa : B01.650.940.800.575.912.250.100.425 [Categoria DeCS]
Referências encontradas : 120 [refinar]
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[PMID]:28479197
[Au] Autor:Mao Z; Gan C; Zhu J; Ma N; Wu L; Wang L; Wang X
[Ad] Endereço:Department of Medicinal Chemistry and Natural Medicine Chemistry, College of Pharmacy, Harbin Medical University, Baojian Road 157, Nangang District, Harbin 150081, PR China; Department of Pharmacy, The 210th Hospital of People Liberation Army, Shanping Street, Dalian 116021, PR China.
[Ti] Título:Anti-atherosclerotic activities of flavonoids from the flowers of Helichrysum arenarium L. MOENCH through the pathway of anti-inflammation.
[So] Source:Bioorg Med Chem Lett;27(12):2812-2817, 2017 06 15.
[Is] ISSN:1464-3405
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:We have successfully established AS model using thoracic aortas vascular ring which evaluated by the morphological changes of blood vessels, the proliferation of VSMC, and the expression of inflammation factors VEGF, CRP, JNK2 and p38. This AS model has the advantages of low cost, convenient and short period of established time. Moreover, we investigated the anti-AS activities of 7 flavonoids Narirutin (1), Naringin (2), Eriodictyol (3), Luteolin (4), Galuteolin (5), Astragalin (6), Kaempferol (7) from flowers of Helichrysum arenarium L. MOENCH by examining the vascular morphology, the inhibition on the expression of inflammation factors CRP, VEGF, JNK2, p38. In addition, we investigated the anti-AS activities of these 7 flavonoids by examining NO secretion of RAW264.7 cells in response to LPS. All above inflammation factors have been proved to be involved in the formation of AS. After comprehensive analysis of all results to discuss the structure-activity relationship, we summarized the conclusions at follow: compounds 1-7 could inhibit the expression of VEGF, CRP, JNK2, p38 and NO at different level, and we evaluated that flavonol aglycone have more significant anti-inflammation than it's glycoside, and the anti-AS activity of flavonols were stronger than flavanones and flavones, which means that 3-group might be the effective group. Eventually, we supposed the main anti-inflammatory mechanism of these compounds was to reduce the expression of CRP, inhibit the kinases activity of JNK2 and p38, and then the MAPK pathway was suppressed, which resulted in the decrease of NO synthesis, VEGF expression and endothelial adhesion factor expression. And eventually, the scar tissue and vascular stenosis formations were prevented. This conclusion suggested flavonoids have the potential of preventing AS formation.
[Mh] Termos MeSH primário: Anti-Inflamatórios não Esteroides/farmacologia
Aterosclerose/tratamento farmacológico
Flavonoides/farmacologia
Flores/química
Helichrysum/química
[Mh] Termos MeSH secundário: Animais
Anti-Inflamatórios não Esteroides/química
Anti-Inflamatórios não Esteroides/isolamento & purificação
Relação Dose-Resposta a Droga
Flavonoides/química
Flavonoides/isolamento & purificação
Lipopolissacarídeos/antagonistas & inibidores
Lipopolissacarídeos/farmacologia
Camundongos
Estrutura Molecular
Óxido Nítrico/antagonistas & inibidores
Óxido Nítrico/biossíntese
Células RAW 264.7
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents, Non-Steroidal); 0 (Flavonoids); 0 (Lipopolysaccharides); 31C4KY9ESH (Nitric Oxide)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171124
[Lr] Data última revisão:
171124
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170509
[St] Status:MEDLINE


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[PMID]:28476462
[Au] Autor:Rosa A; Atzeri A; Nieddu M; Appendino G
[Ad] Endereço:Department of Biomedical Sciences, University of Cagliari, Cittadella Universitaria, SS 554, Km 4.5, 09042 Monserrato, Cagliari, Italy. Electronic address: anrosa@unica.it.
[Ti] Título:New insights into the antioxidant activity and cytotoxicity of arzanol and effect of methylation on its biological properties.
[So] Source:Chem Phys Lipids;205:55-64, 2017 Jun.
[Is] ISSN:1873-2941
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:The heterodimeric phloroglucinyl pyrone arzanol (Arz) has raised considerable interest because of its antiviral, anti-inflammatory, and antioxidant activity. We have investigated the effect of methylation of the pyrone moiety on the antioxidant activity and cytotoxicity of Arz. This manoeuvre, that left the polyphenolic moiety unscathed, was nevertheless detrimental for antioxidant activity in both the cholesterol thermal degradation- and the Cu -induced liposome oxidation assays, providing evidence of structure-activity relationships that go beyond the preservation of the polyphenolic pharmacophore. The antioxidant activity of Arz was retained also in the Fe-NTA model of in vivo oxidative stress, with protective effect on the oxidative degradation of plasmatic lipids, unsaturated fatty acids and cholesterol. Both Arz and methylarzanol (Me-Arz) were devoid of toxic effect on colonic differentiated Caco-2 cells up to 100µM, but significantly reduced cancer Caco-2 cell viability at lower dosages. Arz could also selectively reduce viability of other cancer cell lines, [murine melanoma cells (B16F10 cells), human cervical carcinoma cells (HeLa cells)], suggesting that it can act as a selective modulator of cell processes typical of cancer cells. Taken together, our results qualify Arz as a lead structure for further in vivo investigation of its pharmacological potential.
[Mh] Termos MeSH primário: Antioxidantes/química
Antioxidantes/farmacologia
Floroglucinol/análogos & derivados
Pironas/química
Pironas/farmacologia
[Mh] Termos MeSH secundário: Animais
Linhagem Celular Tumoral
Sobrevivência Celular/efeitos dos fármacos
Colesterol/química
Descoberta de Drogas
Compostos Férricos/química
Helichrysum/química
Seres Humanos
Peroxidação de Lipídeos/efeitos dos fármacos
Masculino
Metilação
Ácido Nitrilotriacético/análogos & derivados
Ácido Nitrilotriacético/química
Oxirredução
Estresse Oxidativo
Floroglucinol/química
Floroglucinol/farmacologia
Extratos Vegetais/química
Extratos Vegetais/farmacologia
Ratos
Ratos Wistar
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Ferric Compounds); 0 (Plant Extracts); 0 (Pyrones); 0 (arzanol); 97C5T2UQ7J (Cholesterol); DHD7FFG6YS (Phloroglucinol); KA90006V9D (Nitrilotriacetic Acid); Z3U5ED15B9 (ferric nitrilotriacetate)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170620
[Lr] Data última revisão:
170620
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170507
[St] Status:MEDLINE


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[PMID]:28445563
[Au] Autor:Tomczyk-Socha M; Jedrzejewska-Jurga K; Limburska J; Tomczyk J
[Ad] Endereço:Department of Ophthalmology, Wroclaw Medical University, Wroclaw, Poland.
[Ti] Título:Outbreak of Occupational Dermatitis Associated With Pyemotes ventricosus.
[So] Source:JAMA Dermatol;153(7):686-688, 2017 Jul 01.
[Is] ISSN:2168-6084
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Importance: Although Pyemotes species have been known to cause dermatitis, recent reports are rare. During the past 30 years, only 3 outbreaks of dermatitis caused by Pyemotes ventricosus have been reported. Objective: To analyze the causative agent of skin changes in employees of a company that produced herbal medicines. Design, Setting, and Participants: This case series includes 18 patients (8 men, 10 women; mean age, 44 years) who contracted unusual dermatitis after an occupational exposure in July and August of 2012 while working for a company that produced herbal medicines. The patients were examined at the Lower Silesia Regional Centre of Occupational Medicine in Wroclaw, Poland. Exposures: Workers weighed and packed 1 part of the Helichrysum arenarium herb. Main Outcomes and Measures: We hypothesized the causative agent to be P ventricosus. An examination of the herbal specimens for ectoparasites confirmed the diagnosis. Results: Initially 16 employees developed pruritic skin changes. Skin lesions with pruritic vesicles on an erythematous base with surrounding swelling and edema were observed. Several employees also developed a flulike illness. After 44 days, 2 new employees presented with the same skin changes. The analysis of working conditions showed that the same part of the H arenarium herb was weighed and packed at that time. Conclusions and Relevance: We found that changing the time when the herbs were weighed and abandoning gas fumigation containing methyl bromide resulted in the recurrence of an almost forgotten disease.
[Mh] Termos MeSH primário: Dermatite Ocupacional/diagnóstico
Surtos de Doenças
Infestações por Ácaros/diagnóstico
Pele/parasitologia
[Mh] Termos MeSH secundário: Adulto
Animais
Dermatite Ocupacional/parasitologia
Feminino
Helichrysum/parasitologia
Seres Humanos
Masculino
Infestações por Ácaros/complicações
Ácaros
Exposição Ocupacional
Polônia
Prurido/parasitologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170724
[Lr] Data última revisão:
170724
[Sb] Subgrupo de revista:AIM; IM
[Da] Data de entrada para processamento:170427
[St] Status:MEDLINE
[do] DOI:10.1001/jamadermatol.2017.0323


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[PMID]:28336139
[Au] Autor:Maksimovic S; Tadic V; Skala D; Zizovic I
[Ad] Endereço:University of Belgrade, Faculty of Technology and Metallurgy, Karnegijeva 4, 11120 Belgrade, Serbia. Electronic address: smaksimovic@tmf.bg.ac.rs.
[Ti] Título:Separation of phytochemicals from Helichrysum italicum: An analysis of different isolation techniques and biological activity of prepared extracts.
[So] Source:Phytochemistry;138:9-28, 2017 Jun.
[Is] ISSN:1873-3700
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Helichrysum italicum presents a valuable source of natural bioactive compounds. In this work, a literature review of terpenes, phenolic compounds, and other less common phytochemicals from H. italicum with regard to application of different separation methods is presented. Data including extraction/separation methods and experimental conditions applied, obtained yields, number of identified compounds, content of different compound groups, and analytical techniques applied are shown as corresponding tables. Numerous biological activities of both isolates and individual compounds are emphasized. In addition, the data reported are discussed, and the directions for further investigations are proposed.
[Mh] Termos MeSH primário: Helichrysum/química
Fenóis/análise
Compostos Fitoquímicos/análise
Terpenos/análise
[Mh] Termos MeSH secundário: Fracionamento Químico/métodos
Óleos Voláteis/análise
Componentes Aéreos da Planta/química
Óleos Vegetais/análise
Solventes/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Oils, Volatile); 0 (Phenols); 0 (Phytochemicals); 0 (Plant Oils); 0 (Solvents); 0 (Terpenes)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170501
[Lr] Data última revisão:
170501
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170325
[St] Status:MEDLINE


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[PMID]:28122144
[Au] Autor:Kasmi A; Hammami M; Raoelison EG; Abderrabba M; Bouajila J; Ducamp C
[Ad] Endereço:Laboratory of Evolution and Biologic Diversity, UMR 5174 CNRS/UPS/ENFA, Narbonne Road PB 22687, 31326, Castanet Tolosan Cedex, France.
[Ti] Título:Chemical Composition and Behavioral Effects of Five Plant Essential Oils on the Green Pea Aphid Acyrthosiphon pisum (Harris) (Homoptera: Aphididae).
[So] Source:Chem Biodivers;14(5), 2017 May.
[Is] ISSN:1612-1880
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Essential oils (EOs) from Schinus molle, Helichrysum gymnocephalum, Cedrelopsis grevei and Melaleuca viridiflora, four aromatic and medicinal plants, are commonly used in folk medicine. EOs were characterized by gas chromatography/mass spectrometry (GC/MS) and quantified by gas chromatography-flame ionization detection (GC-FID); then evaluated for their behavioral effects on adults of the green pea aphid Acyrthosiphon pisum (Harris) using a Perspex four-armed olfactometer in order to test the compatibility of their use as phytoinsecticides to control this insect pest. Our results showed that the EOs from the leaves of S. molle, M. viridiflora and C. grevei did not change aphids' behavior. However, S. molle fruits EO seemed to be attractive while H. gymnocephalum leaves EO exhibited repellency towards aphids at a dose of 10 µl. The major compounds in S. molle fruits EO were 6-epi-shyobunol (16.22%) and d-limonene (15.35%). While, in H. gymnocephalum leaves EO, 1,8-cineole was the main compound (47.4%). The difference in aphids' responses to these two EOs could be attributed to the differences in their compositions. Our findings suggest that these two EOs have potential applications for the integrated pest management of A. pisum (Harris).
[Mh] Termos MeSH primário: Afídeos/efeitos dos fármacos
Inseticidas/isolamento & purificação
Óleos Voláteis/farmacologia
[Mh] Termos MeSH secundário: Animais
Helichrysum/química
Hemípteros/efeitos dos fármacos
Inseticidas/farmacologia
Óleos Voláteis/química
Ervilhas
Plantas Medicinais/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Insecticides); 0 (Oils, Volatile)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170731
[Lr] Data última revisão:
170731
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170126
[St] Status:MEDLINE
[do] DOI:10.1002/cbdv.201600464


  6 / 120 MEDLINE  
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[PMID]:27745694
[Au] Autor:D'Abrosca B; Buommino E; Caputo P; Scognamiglio M; Chambery A; Donnarumma G; Fiorentino A
[Ad] Endereço:Department of Environmental Biological and Pharmaceutical Sciences and Technologies, Second University of Naples, Via Vivaldi 43, 81100, Caserta, Italy. Electronic address: brigida.dabrosca@unina2.it.
[Ti] Título:Phytochemical study of Helichrysum italicum (Roth) G. Don: Spectroscopic elucidation of unusual amino-phlorogucinols and antimicrobial assessment of secondary metabolites from medium-polar extract.
[So] Source:Phytochemistry;132:86-94, 2016 Dec.
[Is] ISSN:1873-3700
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Three unusual amino-phloroglucinols, named helichrytalicines A-C, along with seventeen known compounds including acetophenones, tremetrone derivatives, low-molecular weight phenols, flavonol glucosides, have been isolated from the medium-polar extract of Helichrysum italicum (Roth) G. Don, a medicinal plant typical of the Mediterranean vegetation. The structures of the compounds have been elucidated based on extensive 2D-NMR spectroscopic analyses, including COSY, TOCSY, HSQC, CIGAR-HMBC, H2BC and HSQC-TOCSY, along with Q-TOF HRMS analysis. Stereostructure of the new compounds has been elucidated by Mosher's method and NOESY experiment. Antimicrobial properties against Staphylococcus epidermidis of selected compounds have been evaluated.
[Mh] Termos MeSH primário: Anti-Infecciosos/isolamento & purificação
Helichrysum/química
Floroglucinol/análogos & derivados
Compostos Fitoquímicos
Plantas Medicinais/química
[Mh] Termos MeSH secundário: Acetofenonas
Anti-Infecciosos/química
Anti-Infecciosos/farmacologia
Glucosídeos
Testes de Sensibilidade Microbiana
Ressonância Magnética Nuclear Biomolecular
Fenóis
Floroglucinol/química
Floroglucinol/isolamento & purificação
Floroglucinol/farmacologia
Staphylococcus epidermidis/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acetophenones); 0 (Anti-Infective Agents); 0 (Glucosides); 0 (Phenols); 0 (Phytochemicals); 0 (helichrytalicine A); 0 (helichrytalicine B); 0 (helichrytalicine C); DHD7FFG6YS (Phloroglucinol)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170227
[Lr] Data última revisão:
170227
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161018
[St] Status:MEDLINE


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[PMID]:27502926
[Au] Autor:Giuliani C; Lazzaro L; Calamassi R; Calamai L; Romoli R; Fico G; Foggi B; Mariotti Lippi M
[Ad] Endereço:Department of Pharmaceutical Sciences (DISFARM), University of Milan, Via Mangiagalli 25, I-20133 Milan, Italy.
[Ti] Título:A volatolomic approach for studying plant variability: the case of selected Helichrysum species (Asteraceae).
[So] Source:Phytochemistry;130:128-43, 2016 Oct.
[Is] ISSN:1873-3700
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The species of Helichrysum sect. Stoechadina (Asteraceae) are well-known for their secondary metabolite content and the characteristic aromatic bouquets. In the wild, populations exhibit a wide phenotypic plasticity which makes critical the circumscription of species and infraspecific ranks. Previous investigations on Helichrysum italicum complex focused on a possible phytochemical typification based on hydrodistilled essential oils. Aims of this paper are three-fold: (i) characterizing the volatile profiles of different populations, testing (ii) how these profiles vary across populations and (iii) how the phytochemical diversity may contribute in solving taxonomic problems. Nine selected Helichrysum populations, included within the H. italicum complex, Helichrysum litoreum and Helichrysum stoechas, were investigated. H. stoechas was chosen as outgroup for validating the method. After collection in the wild, plants were cultivated in standard growing conditions for over one year. Annual leafy shoots were screened in the post-blooming period for the emissions of volatile organic compounds (VOCs) by means of headspace solid phase microextraction coupled with gas-chromatography and mass spectrometry (HS-SPME-GC/MS). The VOC composition analysis revealed the production of overall 386 different compounds, with terpenes being the most represented compound class. Statistical data processing allowed the identification of the indicator compounds that differentiate the single populations, revealing the influence of the geographical provenance area in determining the volatile profiles. These results suggested the potential use of VOCs as valuable diacritical characters in discriminating the Helichrysum populations. In addition, the cross-validation analysis hinted the potentiality of this volatolomic study in the discrimination of the Helichrysum species and subspecies, highlighting a general congruence with the current taxonomic treatment of the genus. The consistency between this phytochemical approach and the traditional morphometrical analysis in studying the Helichrysum populations supports the validity of the VOC profile in solving taxonomic problems.
[Mh] Termos MeSH primário: Helichrysum/genética
Compostos Orgânicos Voláteis/análise
[Mh] Termos MeSH secundário: Cromatografia Gasosa-Espectrometria de Massas
Helichrysum/química
Estrutura Molecular
Óleos Voláteis/química
Compostos Orgânicos Voláteis/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Oils, Volatile); 0 (Volatile Organic Compounds)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170224
[Lr] Data última revisão:
170224
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160810
[St] Status:MEDLINE


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[PMID]:27439115
[Au] Autor:Jokic S; Rajic M; Bilic B; Molnar M
[Ad] Endereço:Faculty of Food Technology, Josip Juraj Strossmayer University of Osijek, Franje Kuhaca 20, 31000, Osijek, Croatia.
[Ti] Título:Supercritical Extraction of Scopoletin from Helichrysum italicum (Roth) G. Don Flowers.
[So] Source:Phytochem Anal;27(5):290-5, 2016 Sep.
[Is] ISSN:1099-1565
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:INTRODUCTION: The increasing popularity of immortelle (Helichrysum italicum (Roth) G. Don) and its products, particularly in the cosmetic industry, is evident nowadays. This plant is a source of coumarins, especially scopoletin, which are highly soluble in supercritical CO2 . OBJECTIVE: The objective of this study was to perform the supercritical CO2 extraction process of Helichrysum italicum flowers at different values of pressure and temperature and to optimise the extraction process using response surface methodology in terms of obtaining the highest extraction yield and yield of extracted scopoletin. METHODOLOGY: Extraction was performed in a supercritical extraction system under different extraction conditions of pressure and temperature determined by central composite rotatable design. The mass of flowers in the extractor of 40 g, extraction time of 90 min and CO2 mass flow rate of 1.94 kg/h were kept constant during experiments. Antioxidant activity was determined using the DPPH (1,1-diphenyl-2-picrylhydrazyl) free radical scavenging assay method. Scopoletin concentration was determined by HPLC. RESULTS: Changes in extraction conditions affect the extracting results remarkably. The greatest extraction yield (6.31%) and the highest yield of scopoletin (1.933 mg/100 g) were obtained under extraction conditions of 20 MPa and 40°C. Extracts have also proven to possess antioxidant activity (44.0-58.1% DPPH scavenging activity) influenced by both temperature and pressure applied within the investigated parameters. CONCLUSION: The extraction conditions, especially pressure, exhibited significant influence on the extraction yield as well as the yield of extracted scopoletin and antioxidant activity of extracts. Copyright © 2016 John Wiley & Sons, Ltd.
[Mh] Termos MeSH primário: Cromatografia com Fluido Supercrítico/métodos
Flores/química
Helichrysum/química
Escopoletina/isolamento & purificação
[Mh] Termos MeSH secundário: Antioxidantes/farmacologia
Cromatografia Líquida de Alta Pressão
Espectrofotometria Ultravioleta
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); KLF1HS0SXJ (Scopoletin)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170227
[Lr] Data última revisão:
170227
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160721
[St] Status:MEDLINE
[do] DOI:10.1002/pca.2630


  9 / 120 MEDLINE  
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[PMID]:27085940
[Au] Autor:Onaran M; Orhan N; Farahvash A; Ekin HN; Kocabiyik M; Gönül II; Sen I; Aslan M
[Ad] Endereço:Department of Urology, Faculty of Medicine, Gazi University, 06560 Ankara, Turkey.
[Ti] Título:Successful treatment of sodium oxalate induced urolithiasis with Helichrysum flowers.
[So] Source:J Ethnopharmacol;186:322-328, 2016 Jun 20.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:ETHNOPHARMACOLOGICAL RELEVANCE: Helichrysum (Asteraceae) flowers, known as "altin otu, yayla çiçegi, kudama çiçegi" , are widely used to remove kidney stones and for their diuretic properties in Turkey. AIM OF THE STUDY: To determine the curative effect of infusions prepared from capitulums of Helichrysum graveolens (M. Bieb.) Sweet (HG) and H. stoechas ssp. barellieri (Ten.) Nyman (HS) on sodium oxalate induced kidney stones. MATERIALS AND METHODS: Infusions prepared from the capitulums of HG and HS were tested for their curative effect on calcium oxalate deposition induced by sodium oxalate (70mg/kg i.p.). Following the injection of sodium oxalate for 5 days, plant extracts were administered to rats at two different doses. Potassium citrate was used as positive control. Water intake, urine volume, body, liver and kidney weights were measured; biochemical and hematological analyses were conducted on urine and blood samples. Additionally, histopathological examinations were done on kidney samples. RESULTS: H. stoechas extract showed prominent effect at 156mg/kg dose (stone formation score: 0.33), whereas number of kidney stones was maximum in sodium oxalate group (stone formation score: 2.33). The reduction in the uric acid and oxalate levels of urine samples and the elevation in the urine citrate levels are significant and promising in extract groups. Some hematological, biochemical and enzymatic markers are also ameliorated by the extracts. CONCLUSIONS: This is the first report on the curative effect of immortal flowers. Our preliminary study indicated that Helichrysum extracts may be used for treatment of urolithiasis and Helichrysum extracts are an alternative therapy to potassium citrate for patients suffering from kidney stones.
[Mh] Termos MeSH primário: Helichrysum
Extratos Vegetais/uso terapêutico
Urolitíase/tratamento farmacológico
[Mh] Termos MeSH secundário: Animais
Ácido Cítrico/urina
Flores
Rim/efeitos dos fármacos
Rim/patologia
Masculino
Oxalatos/urina
Ácido Oxálico
Fitoterapia
Ratos Wistar
Ácido Úrico/urina
Urolitíase/induzido quimicamente
Urolitíase/patologia
Urolitíase/urina
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Oxalates); 0 (Plant Extracts); 268B43MJ25 (Uric Acid); 2968PHW8QP (Citric Acid); 9E7R5L6H31 (Oxalic Acid)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170802
[Lr] Data última revisão:
170802
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160418
[St] Status:MEDLINE


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[PMID]:26880428
[Au] Autor:Maggio A; Bruno M; Guarino R; Senatore F; Ilardi V
[Ad] Endereço:Department of Biological, Chemical and Pharmaceutical Sciences and Technologies (STeBiCEF), University of Palermo, Viale delle Scienze, Parco d'Orleans II, IT-90128 Palermo. antonella.maggio@unipa.it.
[Ti] Título:Contribution to a Taxonomic Revision of the Sicilian Helichrysum Taxa by PCA Analysis of Their Essential-Oil Compositions.
[So] Source:Chem Biodivers;13(2):151-9, 2016 Feb.
[Is] ISSN:1612-1880
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:The chemical profile of the essential oils in ten populations of the genus Helichrysum Mill. (Asteraceae), collected in the loci classici of the nomenclatural types of the taxa endemic to Sicily, were analyzed. Our results confirm that the analysis of secondary metabolites can be used to fingerprint wild populations of Helichrysum, the chemical profiles being coherent with the systematic arrangement of the investigated populations in three main clusters, referring to the aggregates of H. stoechas, H. rupestre, and H. italicum, all belonging to the section Stoechadina. The correct nomenclatural designation of the investigated populations is discussed and the following two new combinations are proposed: Helichrysum preslianum subsp. compactum (Guss.) Maggio, Bruno, Guarino, Senatore & Ilardi and Helichrysum panormitanum subsp. latifolium Maggio, Bruno, Guarino, Senatore & Ilardi.
[Mh] Termos MeSH primário: Helichrysum/química
Óleos Voláteis/química
[Mh] Termos MeSH secundário: Cromatografia Gasosa-Espectrometria de Massas
Helichrysum/classificação
Óleos Voláteis/classificação
Análise de Componente Principal
Sicília
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Oils, Volatile)
[Em] Mês de entrada:1610
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160217
[St] Status:MEDLINE
[do] DOI:10.1002/cbdv.201500052



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