Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.100.471 [Categoria DeCS]
Referências encontradas : 239 [refinar]
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[PMID]:28837869
[Au] Autor:Yang Y; Tu R; Sun W; Zhu Z; Zhang Y
[Ad] Endereço:Key Laboratory of Resource Biology and Biotechnology in Western China (Northwest University), Ministry of Education, Xi'an 710069, China; Biomedicine Key Laboratory of Shaanxi Province, College of Life Science, Northwest University, Xi'an 710069, China.
[Ti] Título:Silver perchlorate in the mobile phase for rapid separation and determination of a pair of positional isomers in Inula racemosa Hook.f. with RP-HPLC.
[So] Source:J Chromatogr B Analyt Technol Biomed Life Sci;1063:25-30, 2017 Sep 15.
[Is] ISSN:1873-376X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Alantolactone and isoalantolactone isolated from many species of plants are a pair of positional isomers of CC bond. Previously, alantolactone and isoalantolactone have been proved to be good lead compounds for future anticancer agent development. Similarity of their molecular structures increases the separation difficulty for these two isomers on a conventional C column. Silver perchlorate (AgClO ) as mobile phase additives with RP-HPLC for improving the separation was developed for rapid determination of the positional isomers in Inula racemosa Hook.f. The effects of the concentration of silver perchlorate on the separation of the analytes were investigated. The composition of acetonitrile and water containing 5.0% silver perchlorate in a 65:35 (v/v) ratio was used as mobile phase, in which they were well separated within a short period of time on the C column. The method was successfully applied to determine them in an extract of Inula racemosa Hook.f. root. Silver perchlorate in mobile phase can efficiently improve the separation of the positional isomers and could be applied to rapidly determinate their content in this plant.
[Mh] Termos MeSH primário: Cromatografia Líquida de Alta Pressão/métodos
Inula/química
Lactonas/isolamento & purificação
Percloratos/química
Sesquiterpenos de Eudesmano/isolamento & purificação
Sesquiterpenos/isolamento & purificação
Compostos de Prata/química
[Mh] Termos MeSH secundário: Acetonitrilos/química
Cromatografia de Fase Reversa/métodos
Isomerismo
Lactonas/análise
Lactonas/química
Extratos Vegetais/química
Raízes de Plantas/química
Sesquiterpenos/análise
Sesquiterpenos/química
Sesquiterpenos de Eudesmano/análise
Sesquiterpenos de Eudesmano/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acetonitriles); 0 (Lactones); 0 (Perchlorates); 0 (Plant Extracts); 0 (Sesquiterpenes); 0 (Sesquiterpenes, Eudesmane); 0 (Silver Compounds); 7783-93-9 (silver perchlorate); BYH07P620U (isoalantolactone); M7GSN5Q1M6 (alantolactone); Z072SB282N (acetonitrile)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170825
[St] Status:MEDLINE


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[PMID]:28579553
[Au] Autor:Garayev E; Herbette G; Di Giorgio C; Chiffolleau P; Roux D; Sallanon H; Ollivier E; Elias R; Baghdikian B
[Ad] Endereço:Aix Marseille Univ, UMR-MD3, Laboratory of Pharmacognosy and Ethnopharmacology, Faculty of Pharmacy, 27 bld Jean Moulin, CS 30064, 13385 Marseille, France.
[Ti] Título:New sesquiterpene acid and inositol derivatives from Inula montana L.
[So] Source:Fitoterapia;120:79-84, 2017 Jul.
[Is] ISSN:1873-6971
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:A phytochemical investigation of the ethanol extract of leaves and flowers of Inula montana L. led to the isolation of one new sesquiterpene acid called Eldarin (1) and four new inositol derivatives, Myoinositol,1,5-diangelate-4,6-diacetate (2), Myoinositol,1,6-diangelate-4,5-diacetate (3), Myoinositol-1-angelate-4,5-diacetate-6-(2-methylbutirate) (4), Myoinositol-1-angelate-4,5-diacetate-6-isovalerate (5) isolated for the first time, along with eleven known compounds described for the first time in Inula montana, 1ß-Hydroxyarbusculin A (6), Artemorin (7), Santamarin (8), Chrysosplenol C (9), 6-Hydroxykaempferol 3,7-dimethyl ether (10), Reynosin (11), Calenduladiol-3-palmitate (12), Costunolide (13), 4-Hydroxy-3,5-dimethoxybenzenemethanol (14), 9ß-Hydroxycostunolide (15) and Hispidulin (16). Structural elucidation has been carried out by spectral methods, such as 1D and 2D NMR, IR, UV and HR-ESI-MS. These compounds have been tested in vitro for anti-inflammatory and cytotoxic activity on macrophages RAW 264.7. As a result, compounds 2, 3, 7, 13, 14, 15 and 16 showed a release of NO with IC value <30µM on macrophages.
[Mh] Termos MeSH primário: Anti-Inflamatórios/farmacologia
Inositol/farmacologia
Inula/química
Sesquiterpenos/farmacologia
[Mh] Termos MeSH secundário: Animais
Anti-Inflamatórios/isolamento & purificação
Flores/química
Inositol/isolamento & purificação
Macrófagos/efeitos dos fármacos
Camundongos
Estrutura Molecular
Óxido Nítrico/metabolismo
Folhas de Planta/química
Células RAW 264.7
Sesquiterpenos/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Sesquiterpenes); 31C4KY9ESH (Nitric Oxide); 4L6452S749 (Inositol)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170731
[Lr] Data última revisão:
170731
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170606
[St] Status:MEDLINE


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[PMID]:28502304
[Au] Autor:Long Y; Chen H; Liu L; Guo L
[Ad] Endereço:Department of Burn and Plastic Surgery, First Affiliated Hospital, Chongqing Medical University, Chongqing 400016, China.
[Ti] Título:[Inula Britannica flower total flavonoids reduces the apoptosis of aging bone marrow mesenchymal stem cells by anti-oxidation].
[So] Source:Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi;33(5):649-655, 2017 May.
[Is] ISSN:1007-8738
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:Objective To investigate the beneficial effect of Inula Britannica flower total flavonoids (IBFTF) on aging bone mesenchymal stem cell (BMSC) and its potential mechanism. Methods The aging BMSCs were induced by D-galactose, and then treated with 12.5, 25, 50 µg/mL IBFTF. The cell viability was detected by CCK-8 assay. The activity of catalase (CAT) and superoxide dismutase (SOD), the content of malondialdehyde (MDA) and reactive oxygen species (ROS) were measured by a commercial kit. The apoptosis was assessed by flow cytometry. The protein expressions of BAX, Bcl-2 and cleaved-caspase-3 (c-caspase-3) were determined by Western blotting. Results The cell viability and the activity of SOD and CAT in the aging group decreased significantly compared with the normal group, whereas different concentrations of IBFTF promoted the cell viability, and simultaneously increased the activity of SOD and CAT. The apoptosis, the ROS production, the content of MDA, BAX/Bcl-2 ratio and the protein expression of c-caspase-3 in the aging group increased obviously compared with the normal group. However, the treatment of different concentrations of IBFTF reduced the apoptosis, the ROS production, the content of MDA, BAX/Bcl-2 ratio and the protein expression of c-caspase-3. Conclusion IBFTF can attenuate the apoptosis of aging BMSCs by anti-oxidation.
[Mh] Termos MeSH primário: Envelhecimento/efeitos dos fármacos
Antioxidantes/farmacologia
Apoptose/efeitos dos fármacos
Células da Medula Óssea/efeitos dos fármacos
Flavonoides/farmacologia
Flores/química
Inula/química
Células Mesenquimais Estromais/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Masculino
Extratos Vegetais/farmacologia
Ratos
Ratos Sprague-Dawley
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Flavonoids); 0 (Plant Extracts)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171004
[Lr] Data última revisão:
171004
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170516
[St] Status:MEDLINE


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[PMID]:28278671
[Au] Autor:Todorova M; Trendafilova A; Ivanova V; Danova K; Dimitrov D
[Ad] Endereço:a Institute of Organic Chemistry with Centre of Phytochemistry , Bulgarian Academy of Sciences , Sofia , Bulgaria.
[Ti] Título:Essential oil composition of Inula britannica L. from Bulgaria.
[So] Source:Nat Prod Res;31(14):1693-1696, 2017 Jul.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The separately distilled flowers (F) and leaves' (L) essential oils of Inula britannica L. were investigated using capillary gas chromatography-flame ionization detector (GC-FID) and gas chromatography-mass spectrometry (GC-MS). A total of 83 constituents, representing 96.91% (F) and 96.73% (L) of the total oils, were registered. The oils were rich in terpenoids (57.85% and 77.28%), of which sesquiterpenoids dominated. The main constituents of the essential oils were viridiflorol (7.17%-8.20%) and himachalol (3.45%-8.71%) followed by 6,10,14-trimethyl-2-pentadecanone (5.43%-2.95%), 13-tetradecanolide (3.93%-4.87%) and 3-methyl-4-propyl-2,5-furandione (4.06%-0.29%).
[Mh] Termos MeSH primário: Inula/química
Óleos Voláteis/análise
Óleos Vegetais/análise
[Mh] Termos MeSH secundário: Benzocicloeptenos/análise
Benzocicloeptenos/isolamento & purificação
Bulgária
Flores/química
Cromatografia Gasosa-Espectrometria de Massas/métodos
Óleos Voláteis/química
Folhas de Planta/química
Óleos Vegetais/química
Sesquiterpenos/análise
Sesquiterpenos/isolamento & purificação
Terpenos/análise
Terpenos/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Benzocycloheptenes); 0 (Oils, Volatile); 0 (Plant Oils); 0 (Sesquiterpenes); 0 (Terpenes); 1891-45-8 (himachalol); HN71V2CRMY (viridiflorol)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170311
[St] Status:MEDLINE
[do] DOI:10.1080/14786419.2017.1285295


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[PMID]:28004584
[Au] Autor:Yang M; Lin K
[Ad] Endereço:a College of Life and Environmental Science , Shanghai Normal University , Shanghai , China.
[Ti] Título:Isolation of insecticidal components in Inula salsoloides Ostenf. and characterisation of their activities.
[So] Source:Nat Prod Res;31(17):2049-2052, 2017 Sep.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The ethanol extract from Inula salsoloides (Turcz.) Ostenf was found to cause high mortality against Plutella xylostella L. (Lepidoptera: Plutellidae). The active components were isolated and identified. Two compounds were obtained and identified to be inulasalsolin and taraxasterol. Both compounds showed anti-feedant effects against third instar larvae of P. xylostella with AFC of 0.030 and 0.053 mg/mL and insecticidal activities with LC of 0.19 and 0.49 mg/mL, respectively. The two compounds also exhibited high toxicity to cabbage aphid, Brevicoryne brassicae L. (Hemiptera: Aphididae) with LC values of 0.021 and 0.098 mg/mL. This is the first report on the study of insecticidal components of I. salsoloides and their activity against insects.
[Mh] Termos MeSH primário: Compostos Heterocíclicos de 4 ou mais Anéis/farmacologia
Inseticidas/farmacologia
Inula/química
Esteróis/farmacologia
Triterpenos/farmacologia
[Mh] Termos MeSH secundário: Animais
Afídeos/efeitos dos fármacos
Avaliação Pré-Clínica de Medicamentos/métodos
Compostos Heterocíclicos de 4 ou mais Anéis/química
Compostos Heterocíclicos de 4 ou mais Anéis/isolamento & purificação
Inseticidas/química
Inseticidas/isolamento & purificação
Larva/efeitos dos fármacos
Lepidópteros/efeitos dos fármacos
Estrutura Molecular
Extratos Vegetais/química
Extratos Vegetais/farmacologia
Esteróis/química
Triterpenos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Heterocyclic Compounds, 4 or More Rings); 0 (Insecticides); 0 (Plant Extracts); 0 (Sterols); 0 (Triterpenes); 0 (inulasalsolin); 64SK2ERN9P (taraxasterol)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171017
[Lr] Data última revisão:
171017
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161223
[St] Status:MEDLINE
[do] DOI:10.1080/14786419.2016.1269092


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[PMID]:27988396
[Au] Autor:Gao S; Wang Q; Tian XH; Li HL; Shen YH; Xu XK; Wu GZ; Hu ZL; Zhang WD
[Ad] Endereço:School of Pharmacy, Second Military Medical University, 325 Guohe Road, Yangpu District, Shanghai 200433, China. Electronic address: gaoshuangphu@163.com.
[Ti] Título:Total sesquiterpene lactones prepared from Inula helenium L. has potentials in prevention and therapy of rheumatoid arthritis.
[So] Source:J Ethnopharmacol;196:39-46, 2017 Jan 20.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:BACKGROUNDS: Inula helenium L. is an herb with anti-inflammatory properties. Sesquiterpene lactones (SLs), mainly alantolactone (AL) and isoalantolactone (IAL), are considered as its active ingredients. However, the anti-inflammatory effects of SL-containing extracts of I. helenium have not been explored. Here we prepared total SLs from I. helenium (TSL-IHL), analyzed its chemical constituents, and performed cellular and animal studies to evaluate its anti-inflammatory activities. MATERIALS AND METHODS: The chemical profile of TSL-IHL was analyzed by HPLC-UV. Its in vitro effects on the activation of signaling pathways and expression of inflammatory genes were examined by western blotting and quantitative real-time PCR, respectively, and compared with those of AL and IAL. Its in vivo anti-inflammatory effects were evaluated in adjuvant- and collagen-induced arthritis rat models. RESULTS: Chemical analysis showed that AL and IAL represent major constituents of TSL-IHL. TSL-IHL, as well as AL and IAL, could inhibit TNF-α-induced activation of NF-κB and MAPK pathways in b. End3 cells, suppress the expressions of MMP-3, MCP-1, and IL-1 in TNF-α-stimulated synovial fibroblasts, and IL-1, IL-6, and iNOS in LPS-activated RAW 264.7 cells in a dose-dependent manner in the range of 0.6-2.4µg/mL. Oral administration of TSL-IHL at 12.5-50mg/kg could dose-dependently alleviate the arthritic severity and paw swelling in either developing or developed phases of arthritis of rats induced by adjuvant or collagen CONCLUSIONS: These results indicated potentials of TSL-IHL in prevention and therapy of rheumatoid arthritis.
[Mh] Termos MeSH primário: Anti-Inflamatórios/uso terapêutico
Artrite Experimental/tratamento farmacológico
Artrite Reumatoide/tratamento farmacológico
Inula
Lactonas/uso terapêutico
Sesquiterpenos/uso terapêutico
[Mh] Termos MeSH secundário: Animais
Anti-Inflamatórios/farmacologia
Artrite Experimental/metabolismo
Artrite Experimental/prevenção & controle
Artrite Reumatoide/metabolismo
Artrite Reumatoide/prevenção & controle
Linhagem Celular
Citocinas/genética
Citocinas/metabolismo
Lactonas/farmacologia
Masculino
Camundongos
Proteínas Quinases Ativadas por Mitógeno/metabolismo
NF-kappa B/metabolismo
Raízes de Plantas
Células RAW 264.7
Ratos Wistar
Sesquiterpenos/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Cytokines); 0 (Lactones); 0 (NF-kappa B); 0 (Sesquiterpenes); EC 2.7.11.24 (Mitogen-Activated Protein Kinases)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170713
[Lr] Data última revisão:
170713
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161219
[St] Status:MEDLINE


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[PMID]:27458690
[Au] Autor:Hertel S; Graffy L; Pötschke S; Basche S; Al-Ahmad A; Hoth-Hannig W; Hannig M; Hannig C
[Ad] Endereço:Clinic of Operative and Pediatric Dentistry, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Fetscherstraße 74, D-01307 Dresden, Germany. Electronic address: susann.hertel@uniklinikum-dresden.de.
[Ti] Título:Effect of Inula viscosa on the pellicle's protective properties and initial bioadhesion in-situ.
[So] Source:Arch Oral Biol;71:87-96, 2016 Nov.
[Is] ISSN:1879-1506
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: The present in situ study investigated the effect of Inula viscosa tea on the pellicle's acid protective properties and on initial oral biofilm formation. DESIGN: Biofilm formation was performed on bovine enamel slabs on individual maxillary splints. Following 1min of pellicle formation, eight subjects rinsed for 10min with Inula viscosa tea and the splints remained for 8h intraorally. Samples carried after 1-min rinsing with CHX (0.2%) or without rinse served as controls. BacLight™ staining, 4',6-diamidino-2-phenylindole (DAPI)-staining and fluorescence in situ hybridization (FISH) were used for fluorescence microscopic detection of adherent bacteria. For investigation of acid protective properties, three subjects rinsed for 10min with Inula viscosa tea after 1min pellicle formation and kept the splints intraorally for further 19min. Physiological 30-min pellicles and native enamel samples served as controls. After HCl incubation of the samples ex-vivo over 120s (pH 2.0, 2.3, 3.0) calcium- and phosphate release were quantified photometrically. Potential influences on the pellicle's ultrastructure by Inula viscosa tea were evaluated by transmission electron microscopy (TEM). RESULTS: Application of Inula viscosa tea yielded a significant reduction of adherent bacteria on all enamel samples as detected by fluorescence microscopy. For calcium- and phosphate release no significant effect was recorded. TEM investigation indicated a modification of the pellicle's ultrastructure, but no enhanced protection against erosive noxae. CONCLUSION: Rinsing with Inula viscosa tea influences the bacterial colonization on enamel in situ over 8h but has no impact on acid protective properties of the pellicle.
[Mh] Termos MeSH primário: Biofilmes/efeitos dos fármacos
Película Dentária/microbiologia
Inula
[Mh] Termos MeSH secundário: Adulto
Animais
Aderência Bacteriana/efeitos dos fármacos
Bovinos
Esmalte Dentário/efeitos dos fármacos
Película Dentária/ultraestrutura
Seres Humanos
Hibridização in Situ Fluorescente
Indóis
Microscopia Eletrônica de Transmissão
Microscopia de Fluorescência
Coloração e Rotulagem
Erosão Dentária/prevenção & controle
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Indoles); 47165-04-8 (DAPI)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170403
[Lr] Data última revisão:
170403
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:160727
[St] Status:MEDLINE


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[PMID]:27452450
[Au] Autor:Wu XD; Ding LF; Tu WC; Yang H; Su J; Peng LY; Li Y; Zhao QS
[Ad] Endereço:State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China.
[Ti] Título:Bioactive sesquiterpenoids from the flowers of Inula japonica.
[So] Source:Phytochemistry;129:68-76, 2016 Sep.
[Is] ISSN:1873-3700
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Phytochemical investigation of the flowers of Inula japonica led to isolation of nine sesquiterpenoids, inujaponins A-I, as well as eighteen known ones. These sesquiterpenoids belong to six skeletal-types, including eudesmane, 1,10-seco-eudesmane, germacrane, guaiane, 4,5-seco-guaiane, and pseudoguaiane sesquiterpenoids. Their structures were established by extensive spectroscopic analysis. The absolute configurations of inujaponin A, eupatolide, and deacetylovatifolin were determined by Cu-Kα X-ray crystallographic analysis. Most of the isolated compounds exhibited potent cytotoxicity against HL-60, SMMC-7721, A-549, MCF-7, and SW-480 cancer cell lines, with IC50 values ranging from 1.57 to 22.58 µM. Some selected compounds also possessed significant inhibitory activity against LPS-induced NO production in RAW264.7 macrophages with IC50 values ranging from 1.42 to 8.99 µM.
[Mh] Termos MeSH primário: Flores/química
Inula/química
Sesquiterpenos de Eudesmano/isolamento & purificação
[Mh] Termos MeSH secundário: Animais
Cristalografia por Raios X
Células HL-60
Seres Humanos
Concentração Inibidora 50
Lipopolissacarídeos/farmacologia
Macrófagos/efeitos dos fármacos
Camundongos
Conformação Molecular
Estrutura Molecular
Óxido Nítrico/biossíntese
Sesquiterpenos/química
Sesquiterpenos/isolamento & purificação
Sesquiterpenos/farmacologia
Sesquiterpenos de Eudesmano/química
Sesquiterpenos de Eudesmano/farmacologia
Sesquiterpenos de Guaiano/química
Sesquiterpenos de Guaiano/isolamento & purificação
Sesquiterpenos de Guaiano/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Lipopolysaccharides); 0 (Sesquiterpenes); 0 (Sesquiterpenes, Eudesmane); 0 (Sesquiterpenes, Guaiane); 0 (guaiane); 31C4KY9ESH (Nitric Oxide); 473-11-0 (eudesmane); 6750-25-0 (eupatolide)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170224
[Lr] Data última revisão:
170224
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160726
[St] Status:MEDLINE


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[PMID]:27276091
[Au] Autor:Jin Q; Lee JW; Jang H; Choi JE; Lee D; Hong JT; Kim Y; Lee MK; Hwang BY
[Ad] Endereço:College of Pharmacy, Chungbuk National University , Cheongju 28644, Korea.
[Ti] Título:Sesquiterpenes from Inula japonica with Inhibitory Effects on Nitric Oxide Production in Murine Macrophage RAW 264.7 Cells.
[So] Source:J Nat Prod;79(6):1548-53, 2016 Jun 24.
[Is] ISSN:1520-6025
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Eight new sesquiterpenes (1-8), along with seven known sesquiterpenes (9-15), were isolated from a methanol extract of the flowers of Inula japonica. Their structures were elucidated by a combination of 1D and 2D NMR spectroscopic and HRESIMS data. All of isolates were evaluated for their inhibitory effects on nitric oxide production in LPS-induced RAW 264.7 cells, with their IC50 values ranging from 1.9 to 15.4 µM.
[Mh] Termos MeSH primário: Flores/química
Inula/química
Óxido Nítrico/biossíntese
Sesquiterpenos/isolamento & purificação
Sesquiterpenos/farmacologia
[Mh] Termos MeSH secundário: Animais
Anti-Inflamatórios não Esteroides
Concentração Inibidora 50
Lactonas/química
Lipopolissacarídeos/farmacologia
Macrófagos/efeitos dos fármacos
Camundongos
Estrutura Molecular
Ressonância Magnética Nuclear Biomolecular
Componentes Aéreos da Planta/química
Células RAW 264.7
República da Coreia
Sesquiterpenos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents, Non-Steroidal); 0 (Lactones); 0 (Lipopolysaccharides); 0 (Sesquiterpenes); 31C4KY9ESH (Nitric Oxide)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170517
[Lr] Data última revisão:
170517
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160609
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jnatprod.5b01106


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[PMID]:27231873
[Au] Autor:Gou JB; Li ZQ; Li CF; Chen FF; Lv SY; Zhang YS
[Ad] Endereço:CAS Key Laboratory of Plant Germplasm Enhancement and Specialty Agriculture, Wuhan Botanical Garden, Chinese Academy of Sciences, Wuhan 430071, China; Graduate University of Chinese Academy of Sciences, Beijing 100049, China.
[Ti] Título:Molecular cloning and functional analysis of a 10-epi-junenol synthase from Inula hupehensis.
[So] Source:Plant Physiol Biochem;106:288-94, 2016 Sep.
[Is] ISSN:1873-2690
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:Junenol based-eudesmanolides have been detected in many compositae plant species and were reported to exhibit various pharmacological activities. So far, the gene encoding junenol synthase has never been isolated. Here we report the molecular cloning and functional analysis of a 10-epi-junenol synthase from Inula hupehensis (designated IhsTPS1). IhsTPS1 converts the substrate farnesyl diphosphate into multiple sesquiterpenes with the product 10-epi-junenol being predominant. The transcript levels of IhsTPS1 correlate well with the accumulation pattern of 10-epi-junenol in I. hupehensis organs, supporting its biochemical roles in vivo.
[Mh] Termos MeSH primário: Alquil e Aril Transferases/genética
Inula/enzimologia
Inula/genética
Proteínas de Plantas/genética
[Mh] Termos MeSH secundário: Alquil e Aril Transferases/metabolismo
Vias Biossintéticas/genética
Clonagem Molecular
DNA Complementar/genética
Cromatografia Gasosa-Espectrometria de Massas
Regulação Enzimológica da Expressão Gênica
Regulação da Expressão Gênica de Plantas
Filogenia
Proteínas de Plantas/metabolismo
Fosfatos de Poli-Isoprenil/metabolismo
RNA Mensageiro/genética
RNA Mensageiro/metabolismo
Sesquiterpenos/química
Sesquiterpenos/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Complementary); 0 (Plant Proteins); 0 (Polyisoprenyl Phosphates); 0 (RNA, Messenger); 0 (Sesquiterpenes); 0 (eudesmanolide); 79W6B01D07 (farnesyl pyrophosphate); EC 2.5.- (Alkyl and Aryl Transferases); EC 2.5.1.- (terpene synthase)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170327
[Lr] Data última revisão:
170327
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160528
[St] Status:MEDLINE



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