Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.100.506 [Categoria DeCS]
Referências encontradas : 49 [refinar]
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[PMID]:28373010
[Au] Autor:Wu J; Gao L; Shang L; Wang G; Wei N; Chu T; Chen S; Zhang Y; Huang J; Wang J; Lin R
[Ad] Endereço:School of Traditional Chinese Materia Medica, Key Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China.
[Ti] Título:Ecdysterones from Rhaponticum carthamoides (Willd.) Iljin reduce hippocampal excitotoxic cell loss and upregulate mTOR signaling in rats.
[So] Source:Fitoterapia;119:158-167, 2017 Jun.
[Is] ISSN:1873-6971
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Glutamate-induced excitotoxicity is a key pathological mechanism in many neurological disease states. Ecdysterones derived from Rhaponticum carthamoides (Willd.) Iljin (RCI) have been shown to alleviate glutamate-induced neuronal damage; although their mechanism of action is unclear, some data suggest that they enhance signaling in the mechanistic target of rapamycin (mTOR) signaling pathway. This study sought to elucidate the mechanisms underlying ecdysterone-mediated neuroprotection. We used in silico target prediction and simulation methods to identify putative ecdysterone binding targets, and to specifically identify those that represent nodes where several neurodegenerative diseases converge. We then used histological analyses in a rat hippocampal excitotoxicity model to test the effectiveness of ecdysterones in vivo. We found that RCI-derived ecdysterones should bind to glutamatergic NMDA-type receptors (NMDARs); specifically, in vivo modeling showed binding to the GRIN2B subunit of NMDARs, which was found also to be a node of convergence in several neurodegenerative disease pathways. Computerized network construction by using pathway information from the Kyoto Encyclopedia of Genes and Genomes (KEGG) database showed putative links between GRIN2B and mTOR pathway elements including phosphoinositide-3kinase (PI3K), mTOR, and protein kinase C (PKC); these elements are associated with neuronal survival. Brain tissue western blots of ecdysterone-treated rats showed upregulated PI3K, Akt, mTOR, and phosphorylated Akt and mTOR, and down regulated GRIN2B and the apoptotic enzyme cleaved caspase-3. Ecdysterone treatment also prevented glutamate-induced rat hippocampal cell loss. In summary, RCI-derived ecdysterones appear to prevent glutamatergic excitotoxicity by increasing mTOR/Akt/PI3K signaling activity.
[Mh] Termos MeSH primário: Ecdisterona/farmacologia
Hipocampo/efeitos dos fármacos
Leuzea/química
Fármacos Neuroprotetores/farmacologia
Transdução de Sinais/efeitos dos fármacos
Serina-Treonina Quinases TOR/metabolismo
[Mh] Termos MeSH secundário: Animais
Caspase 3/metabolismo
Ecdisterona/isolamento & purificação
Ácido Glutâmico/farmacologia
Hipocampo/citologia
Masculino
Simulação de Acoplamento Molecular
Simulação de Dinâmica Molecular
Estrutura Molecular
Fármacos Neuroprotetores/isolamento & purificação
Fosforilação
Raízes de Plantas/química
Proteínas Proto-Oncogênicas c-akt/metabolismo
Ratos
Ratos Sprague-Dawley
Receptores de N-Metil-D-Aspartato/metabolismo
Regulação para Cima
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (NR2B NMDA receptor); 0 (Neuroprotective Agents); 0 (Receptors, N-Methyl-D-Aspartate); 3KX376GY7L (Glutamic Acid); 5289-74-7 (Ecdysterone); EC 2.7.1.1 (TOR Serine-Threonine Kinases); EC 2.7.1.1 (mTOR protein, rat); EC 2.7.11.1 (Proto-Oncogene Proteins c-akt); EC 3.4.22.- (Casp3 protein, rat); EC 3.4.22.- (Caspase 3)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170615
[Lr] Data última revisão:
170615
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170405
[St] Status:MEDLINE


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[PMID]:28074117
[Au] Autor:Skala E; Rijo P; Garcia C; Sitarek P; Kalemba D; Toma M; Szemraj J; Pytel D; Wysokinska H; Sliwinski T
[Ad] Endereço:Department of Biology and Pharmaceutical Botany, Medical University of Lodz, Muszynskiego 1, 90-151 Lodz, Poland.
[Ti] Título:The Essential Oils of Hairy Roots and Roots of Soil-Grown Plants: Chemical Composition and Antimicrobial, Anti-Inflammatory, and Antioxidant Activities.
[So] Source:Oxid Med Cell Longev;2016:8505384, 2016.
[Is] ISSN:1942-0994
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The essential oils were isolated by hydrodistillation from the hairy roots (HR) and roots of soil-grown plants (SGR) of and were analyzed by GC-MS method. In the both essential oils 62 compounds were identified. The root essential oils showed the differences in the qualitative and quantitative composition. The sesquiterpene hydrocarbons (55-62%) dominated in both essential oils. The major compounds of HR essential oil were cyperene, 13-norcypera-1(5),11(12)-diene, and cadalene while aplotaxene, nardosina-1(10),11-diene, and dauca-4(11),8-diene dominated in SGR essential oil. Both essential oils showed antibacterial activity especially against (ATCC 29212) and (ATCC 27853) (MIC value = 125 g/mL). HR and SGR essential oils also decreased the expression of IL-1 , IL-6, and TNF- and the ROS level in LPS-treatment astrocytes. This is the first report to describe the chemical composition of essential oil from hairy roots, its protective effect against LPS-induced inflammation and ROS production in astrocytes, and its antimicrobial potential. The results show that hairy roots may be a valuable source of the essential oil and may be an alternative to the roots of soil-grown plants.
[Mh] Termos MeSH primário: Anti-Infecciosos/química
Anti-Inflamatórios/química
Leuzea/metabolismo
Óleos Voláteis/química
[Mh] Termos MeSH secundário: Anti-Infecciosos/farmacologia
Anti-Inflamatórios/farmacologia
Astrócitos/citologia
Astrócitos/efeitos dos fármacos
Astrócitos/metabolismo
Candida albicans/efeitos dos fármacos
Linhagem Celular
Enterococcus faecalis/efeitos dos fármacos
Ensaio de Imunoadsorção Enzimática
Cromatografia Gasosa-Espectrometria de Massas
Seres Humanos
Interleucina-1beta/análise
Interleucina-6/análise
Leuzea/crescimento & desenvolvimento
Lipopolissacarídeos/toxicidade
Testes de Sensibilidade Microbiana
Óleos Voláteis/análise
Óleos Voláteis/farmacologia
Raízes de Plantas/metabolismo
Pseudomonas aeruginosa/efeitos dos fármacos
Espécies Reativas de Oxigênio/metabolismo
Saccharomyces cerevisiae/efeitos dos fármacos
Fator de Necrose Tumoral alfa/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Infective Agents); 0 (Anti-Inflammatory Agents); 0 (Interleukin-1beta); 0 (Interleukin-6); 0 (Lipopolysaccharides); 0 (Oils, Volatile); 0 (Reactive Oxygen Species); 0 (Tumor Necrosis Factor-alpha)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170306
[Lr] Data última revisão:
170306
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170112
[St] Status:MEDLINE
[do] DOI:10.1155/2016/8505384


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[PMID]:27696406
[Au] Autor:Skala E; Sitarek P; Toma M; Szemraj J; Radek M; Nieborowska-Skorska M; Skorski T; Wysokinska H; Sliwinski T
[Ad] Endereço:Department of Biology and Pharmaceutical Botany, Medical University of Lódz, Poland. ewa.skala@umed.lodz.pl.
[Ti] Título:Inhibition of human glioma cell proliferation by altered Bax/Bcl-2-p53 expression and apoptosis induction by Rhaponticum carthamoides extracts from transformed and normal roots.
[So] Source:J Pharm Pharmacol;68(11):1454-1464, 2016 Nov.
[Is] ISSN:2042-7158
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: The objective of this study was to determine the cytotoxic effect and apoptotic activity of Rhaponticum carthamoides transformed root (TR) and root of soil-grown plant (NR) extracts in a human glioma primary cells. The effect of these root extracts on cell cycle arrest, mitochondrial membrane potential (ΔΨm) and expression levels of apoptosis-related genes (Bcl-2, Bax and p53) were also examined. METHODS: Cytotoxic activity of root extracts was evaluated by MTT assay. Apoptosis and cell cycle were determined by flow cytometry. Expression levels of apoptosis-related gene were analysed by RT-PCR and Western blotting. ΔΨm was examined by the use of JC-1 reagent. KEY FINDINGS: Rhaponticum carthamoides root extracts inhibit cell growth and induce apoptosis in a dose-dependent manner in human glioma cells. The root extracts were found to up-regulate the pro-apoptotic Bax protein and down-regulate the anti-apoptotic Bcl-2 protein, consequently increasing the ratios of Bax/Bcl-2 protein levels. Moreover, an increase of the p53 protein level and reduction of ΔΨm in glioma cells were observed after treatment with NR and TR extracts. CONCLUSION: The results of this study may offer a new insight into the potential anticancer activity of R. carthamoides root extracts.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/farmacologia
Neoplasias Encefálicas/tratamento farmacológico
Proliferação Celular/efeitos dos fármacos
Glioma/tratamento farmacológico
Leuzea/química
Extratos Vegetais/farmacologia
Raízes de Plantas/química
Proteínas Proto-Oncogênicas c-bcl-2/metabolismo
Proteína Supressora de Tumor p53/metabolismo
Proteína X Associada a bcl-2/metabolismo
[Mh] Termos MeSH secundário: Agrobacterium/fisiologia
Antineoplásicos Fitogênicos/isolamento & purificação
Apoptose/efeitos dos fármacos
Western Blotting
Neoplasias Encefálicas/genética
Neoplasias Encefálicas/metabolismo
Neoplasias Encefálicas/patologia
Pontos de Checagem do Ciclo Celular/efeitos dos fármacos
Relação Dose-Resposta a Droga
Glioma/genética
Glioma/metabolismo
Glioma/patologia
Leuzea/microbiologia
Potencial da Membrana Mitocondrial/efeitos dos fármacos
Microscopia de Fluorescência
Fitoterapia
Extratos Vegetais/isolamento & purificação
Raízes de Plantas/microbiologia
Plantas Medicinais
Proteínas Proto-Oncogênicas c-bcl-2/genética
Reação em Cadeia da Polimerase Via Transcriptase Reversa
Transdução de Sinais/efeitos dos fármacos
Transformação Bacteriana
Proteína Supressora de Tumor p53/genética
Proteína X Associada a bcl-2/genética
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (BAX protein, human); 0 (BCL2 protein, human); 0 (Plant Extracts); 0 (Proto-Oncogene Proteins c-bcl-2); 0 (TP53 protein, human); 0 (Tumor Suppressor Protein p53); 0 (bcl-2-Associated X Protein)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170516
[Lr] Data última revisão:
170516
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161004
[St] Status:MEDLINE
[do] DOI:10.1111/jphp.12619


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[PMID]:27524868
[Au] Autor:Jeong YH; Oh YC; Cho WK; Yim NH; Ma JY
[Ad] Endereço:Korean Medicine (KM) Application Center, Korea Institute of Oriental Medicine, 70 Cheomdan-ro, Dong-gu, Daegu 41062, Republic of Korea.
[Ti] Título:Anti-Inflammatory Effect of Rhapontici Radix Ethanol Extract via Inhibition of NF-κB and MAPK and Induction of HO-1 in Macrophages.
[So] Source:Mediators Inflamm;2016:7216912, 2016.
[Is] ISSN:1466-1861
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Rhapontici Radix (RR) has been used in traditional medicine in East Asia and has been shown to have various beneficial effects. However, its biological properties or mechanism on inflammation-related diseases is unknown. The goal of this study was to determine the anti-inflammatory activity and underlying molecular mechanisms of Rhapontici Radix ethanol extract (RRE). The inhibitory effect of RRE on the production of NO, cytokines, inflammatory-related proteins, and mRNAs in LPS-stimulated macrophages was determined by the Griess assay, ELISA, Western blot analysis, and real-time RT-PCR, respectively. Our results indicate that treatment with RRE significantly inhibited the secretion of NO and inflammatory cytokines in RAW 264.7 cells and mouse peritoneal macrophages without cytotoxicity. We also found that RRE strongly suppressed the expression of iNOS and COX-2 and induced HO-1 expression. It also prevented nuclear translocation of NF-κB by inhibiting the phosphorylation and degradation of IκBα. Furthermore, the phosphorylation of MAPKs in LPS-stimulated RAW 264.7 cells was significantly inhibited by RRE. These findings suggest that RRE may operate as an effective anti-inflammatory agent by inhibiting the activation of NF-κB and MAPK signaling pathways and inducing HO-1 expression in macrophages. Our results suggest that RRE has potential value as candidate to inflammatory therapeutic phytomedicine.
[Mh] Termos MeSH primário: Heme Oxigenase-1/metabolismo
Inflamação/tratamento farmacológico
Inflamação/metabolismo
Leuzea/química
Macrófagos/efeitos dos fármacos
Macrófagos/metabolismo
Proteínas de Membrana/metabolismo
Proteínas Quinases Ativadas por Mitógeno/metabolismo
NF-kappa B/metabolismo
Extratos Vegetais/uso terapêutico
[Mh] Termos MeSH secundário: Animais
Western Blotting
Sobrevivência Celular/efeitos dos fármacos
Etanol/química
Heme Oxigenase-1/genética
Inflamação/genética
Masculino
Proteínas de Membrana/genética
Camundongos
Camundongos Endogâmicos BALB C
Proteínas Quinases Ativadas por Mitógeno/genética
Células RAW 264.7
Reação em Cadeia da Polimerase em Tempo Real
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Membrane Proteins); 0 (NF-kappa B); 0 (Plant Extracts); 3K9958V90M (Ethanol); EC 1.14.14.18 (Heme Oxygenase-1); EC 1.14.14.18 (Hmox1 protein, mouse); EC 2.7.11.24 (Mitogen-Activated Protein Kinases)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170519
[Lr] Data última revisão:
170519
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160816
[St] Status:MEDLINE
[do] DOI:10.1155/2016/7216912


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[PMID]:27034736
[Au] Autor:Skala E; Sitarek P; Rózalski M; Krajewska U; Szemraj J; Wysokinska H; Sliwinski T
[Ad] Endereço:Department of Biology and Pharmaceutical Botany, Medical University of Lódz, Muszynskiego 1, 90-151 Lódz, Poland.
[Ti] Título:Antioxidant and DNA Repair Stimulating Effect of Extracts from Transformed and Normal Roots of Rhaponticum carthamoides against Induced Oxidative Stress and DNA Damage in CHO Cells.
[So] Source:Oxid Med Cell Longev;2016:5753139, 2016.
[Is] ISSN:1942-0994
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Rhaponticum carthamoides has a long tradition of use in Siberian folk medicine. The roots and rhizomes of this species are used in various dietary supplements or nutraceutical preparations to increase energy level or eliminate physical weakness. This is the first report to reveal the protective and DNA repair stimulating abilities of R. carthamoides root extracts in Chinese hamster ovary (CHO) cells exposed to an oxidative agent. Both transformed root extract (TR extract) and extract of soil-grown plant roots (NR extract) may be responsible for stimulating CHO cells to repair oxidatively induced DNA damage, but CHO cells stimulated with extract from the transformed roots demonstrated significantly stronger properties than cells treated with the soil-grown plant root extract. These differences in biological activity may be attributed to the differences in the content of phenolic compounds in these root extracts. Preincubation of the CHO cells with TR and NR extracts showed an increase in gene expression and protein levels of catalase (CAT) and superoxide dismutase (SOD2). R. carthamoides may possess antioxidant properties that protect CHO cells against oxidative stress.
[Mh] Termos MeSH primário: Antioxidantes/farmacologia
Dano ao DNA
Reparo do DNA/efeitos dos fármacos
Leuzea/química
Estresse Oxidativo/efeitos dos fármacos
Extratos Vegetais/farmacologia
Raízes de Plantas/química
[Mh] Termos MeSH secundário: Animais
Antioxidantes/química
Células CHO
Cricetinae
Cricetulus
Extratos Vegetais/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antioxidants); 0 (Plant Extracts)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160402
[St] Status:MEDLINE
[do] DOI:10.1155/2016/5753139


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[PMID]:27021083
[Au] Autor:Ivanov SD; Bespalov VG; Semenov AL; Kovan'ko EG; Aleksandrov VA
[Ad] Endereço:Russian Research Center of Radiology and Surgical Technologies, Ministry of Health of the Russian Federation, St. Petersburg, Russia. sergey.d.ivanov@mail.ru.
[Ti] Título:Toxicogenomic Effects in Rat Blood Leukocytes and Chemoprophylaxis of Radiation-Induced Carcinogenesis.
[So] Source:Bull Exp Biol Med;160(5):705-8, 2016 Mar.
[Is] ISSN:1573-8221
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Toxicogenomic parameters were studied in the blood of female rats after exposure to ionizing γ-radiation in a dose of 4 Gy and chemoprophylaxis with α-difluoromethylornithine, eleutherococcus or leuzea extracts, which were used in animals with morphological manifestations of tumor growth under conditions of radiation-induced carcinogenesis. Life-time evaluation of toxicogenomic effects was carried out by express method for measurements of blood nucleotid DNA - fluorescent indication. The level of hyperaneu/polyploidy increased in the blood leukocytes of control rats 30 days after radiation exposure. A significant decrease of genotoxicity as a result of drug treatment in comparison with the number and multiplicity of tumors in irradiated animals was found only in the endocrine and reproductive organs of rats treated by eleutherococcus extract.
[Mh] Termos MeSH primário: Quimioprevenção/métodos
Eflornitina/uso terapêutico
Eleutherococcus/metabolismo
Leucócitos/efeitos da radiação
Leuzea/metabolismo
Neoplasias Induzidas por Radiação/tratamento farmacológico
Neoplasias Induzidas por Radiação/mortalidade
Extratos Vegetais/uso terapêutico
[Mh] Termos MeSH secundário: Animais
DNA/genética
Feminino
Raios gama/efeitos adversos
Leucócitos/citologia
Neoplasias Induzidas por Radiação/patologia
Poliploidia
Radiação Ionizante
Ratos
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Extracts); 9007-49-2 (DNA); ZQN1G5V6SR (Eflornithine)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170110
[Lr] Data última revisão:
170110
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160330
[St] Status:MEDLINE
[do] DOI:10.1007/s10517-016-3255-z


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[PMID]:25811023
[Au] Autor:Skala E; Kicel A; Olszewska MA; Kiss AK; Wysokinska H
[Ad] Endereço:Department of Biology and Pharmaceutical Botany, Medical University of Lódz, Muszynskiego 1, 90-151 Lódz, Poland.
[Ti] Título:Establishment of hairy root cultures of Rhaponticum carthamoides (Willd.) Iljin for the production of biomass and caffeic acid derivatives.
[So] Source:Biomed Res Int;2015:181098, 2015.
[Is] ISSN:2314-6141
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The aim of the study was to obtain transformed roots of Rhaponticum carthamoides and evaluate their phytochemical profile. Hairy roots were induced from leaf explants by the transformation of Agrobacterium rhizogenes strains A4 and ATCC 15834. The best response (43%) was achieved by infection with A4 strain. The effects of different liquid media (WPM, B5, SH) with full and half-strength concentrations of macro- and micronutrients on biomass accumulation of the best grown hairy root line (RC3) at two different lighting conditions (light or dark) were investigated. The highest biomass (93 g L(-1) of the fresh weight after 35 days) was obtained in WPM medium under periodic light. UPLC-PDA-ESI-MS(3) and HPLC-PDA analyses of 80% aqueous methanol extracts from the obtained hairy roots revealed the presence of eleven caffeoylquinic acids and their derivatives and five flavonoid glycosides. The production of caffeoylquinic acids and their derivatives was elevated in hairy roots grown in the light. Only light-grown hairy roots demonstrated the capability for the biosynthesis of such flavonoid glycosides as quercetagetin, quercetin, luteolin, and patuletin hexosides. Chlorogenic acid, 3,5-di-O-caffeoylquinic acid and a tentatively identified tricaffeoylquinic acid derivative were detected as the major compounds present in the transformed roots.
[Mh] Termos MeSH primário: Biomassa
Ácidos Cafeicos/metabolismo
Leuzea/crescimento & desenvolvimento
Raízes de Plantas/crescimento & desenvolvimento
Técnicas de Cultura de Tecidos/métodos
[Mh] Termos MeSH secundário: Agrobacterium
Cromatografia Líquida de Alta Pressão
Meios de Cultura
DNA de Plantas/isolamento & purificação
Ecdisterona/metabolismo
Reação em Cadeia da Polimerase
Polifenóis/metabolismo
Espectrometria de Massas por Ionização por Electrospray
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Caffeic Acids); 0 (Culture Media); 0 (DNA, Plant); 0 (Polyphenols); 5289-74-7 (Ecdysterone); U2S3A33KVM (caffeic acid)
[Em] Mês de entrada:1512
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150327
[St] Status:MEDLINE
[do] DOI:10.1155/2015/181098


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[PMID]:24913295
[Au] Autor:Bespalov VG; Alexandrov VA; Semenov AL; Kovan'Ko EG; Ivanov SD
[Ad] Endereço:N.N. Petrov Research Institute of Oncology of the Ministry of Health of the Russian Federation , St. Petersburg , Russia.
[Ti] Título:Anticarcinogenic activity of alpha-difluoromethylornithine, ginseng, eleutherococcus, and leuzea on radiation-induced carcinogenesis in female rats.
[So] Source:Int J Radiat Biol;90(12):1191-200, 2014 Dec.
[Is] ISSN:1362-3095
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To carry out a comparative study of inhibition of radiation carcinogenesis using alpha-difluoromethylornithine (DFMO), tinctures of ginseng, eleutherococcus and leuzea in female rats. MATERIALS AND METHODS: Locally bred female LIO-strain rats were subjected to a single whole body γ-irradiation dose of 4 Gy at 12 weeks of age. Modifying drugs were given with drinking water from the 10th day after irradiation until the end of the experiment (for 16 months). RESULTS: Irradiated rats developed tumors 70.0-79.6% (malignant tumors: 43.7-45.0%) with a multiplicity of 1.48-1.75 (malignant: 0.5-0.58), while in unirradiated animals the incidence of all/malignant tumors was 21.9%/7.7% with multiplicity of 0.22/0.08. In exposed rats tumors most often developed in the mammary gland - 57.3%, reproductive and endocrine organs - 27.2%, and other localizations - 29.1%. All drugs, except leuzea, significantly reduced incidence and multiplicity of tumors, overall or at some localizations in irradiated rats. Highest, and practically equal inhibition, was shown by ginseng and DFMO, while eleutherococcus was clearly inferior. Ginseng reduced overall tumor incidence and multiplicity by 1.5 and 2.4 times, malignant tumor incidence and multiplicity - by 2.5 and 2.9 times, respectively. CONCLUSIONS: The ginseng extract is the most promising radiation carcinogenesis inhibitor tested.
[Mh] Termos MeSH primário: Anticarcinógenos/farmacologia
Carcinogênese/efeitos dos fármacos
Carcinogênese/efeitos da radiação
Eflornitina/farmacologia
Eleutherococcus/química
Leuzea/química
Panax/química
[Mh] Termos MeSH secundário: Animais
Feminino
Raios gama/efeitos adversos
Ratos
Análise de Sobrevida
Irradiação Corporal Total/efeitos adversos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anticarcinogenic Agents); ZQN1G5V6SR (Eflornithine)
[Em] Mês de entrada:1502
[Cu] Atualização por classe:141204
[Lr] Data última revisão:
141204
[Sb] Subgrupo de revista:IM; S
[Da] Data de entrada para processamento:140611
[St] Status:MEDLINE
[do] DOI:10.3109/09553002.2014.932937


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[PMID]:24483775
[Au] Autor:Sólyomváry A; Mervai Z; Molnár-Perl I; Boldizsár I
[Ad] Endereço:a Department of Plant Anatomy , Institute of Biology, Eötvös Loránd University , Pázmány Péter sétány 1/C, Budapest 1117 , Hungary.
[Ti] Título:Specific hydrolysis and accumulation of antiproliferative lignans in the fruit of Leuzea carthamoides (Willd.) DC.
[So] Source:Nat Prod Res;28(10):732-9, 2014.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Dibenzylbutyrolactone-type lignan glycosides (tracheloside and carthamoside), their aglycones (trachelogenin and carthamogenin) and feruloyl-serotonin isomers were determined in the fruits of Leuzea carthamoides by using LC-UV, LC-MS/MS and GC-MS techniques. The composition of the embryo and wall parts of the fruits was analysed before and after their hydrolysis. As a result of these studies, fruit part-specific accumulation of lignan glycosides and feruloyl-serotonins were confirmed, demonstrating that the embryo contains a high amount of lignan glycosides (tracheloside 32.9 mg/g, carthamoside 45.3 mg/g), while the wall part of the fruit accumulates feruloyl-serotonins (63.0 mg/g). Enzymatic hydrolysis of the embryo resulted in the quantitative transformation of lignan glycosides into their corresponding aglycones, allowing selective isolation of trachelogenin and carthamogenin. These aglycones were subjected to an antiproliferative study against the SW480 colon adenocarcinoma cell line. In this test, moderate activity of carthamogenin and a significant effect of trachelogenin were demonstrated in a concentration range of 22-185 µM.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/isolamento & purificação
Antineoplásicos Fitogênicos/farmacologia
Frutas/química
Glicosídeos/isolamento & purificação
Glicosídeos/farmacologia
Leuzea/química
Lignanas/isolamento & purificação
Lignanas/farmacologia
[Mh] Termos MeSH secundário: 4-Butirolactona/análogos & derivados
4-Butirolactona/análise
Antineoplásicos Fitogênicos/química
Ensaios de Seleção de Medicamentos Antitumorais
Cromatografia Gasosa-Espectrometria de Massas
Glicosídeos/química
Seres Humanos
Hungria
Hidrólise
Lignanas/análise
Lignanas/química
Estrutura Molecular
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Glycosides); 0 (Lignans); 0 (carthamogenin); 0 (trachelogenin); OL659KIY4X (4-Butyrolactone)
[Em] Mês de entrada:1410
[Cu] Atualização por classe:140507
[Lr] Data última revisão:
140507
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140204
[St] Status:MEDLINE
[do] DOI:10.1080/14786419.2013.879473


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[PMID]:24444255
[Au] Autor:Dushkin M; Khrapova M; Kovshik G; Chasovskikh M; Menshchikova E; Trufakin V; Shurlygina A; Vereschagin E
[Ad] Endereço:Laboratory of Molecular and Cellular Mechanisms of Therapeutic Diseases, Institute of Internal Medicine, Siberian Branch of the Russian Academy of Medical Sciences, Novosibirsk, Russia. midushkin@soramn.ru.
[Ti] Título:Effects of rhaponticum carthamoides versus glycyrrhiza glabra and punica granatum extracts on metabolic syndrome signs in rats.
[So] Source:BMC Complement Altern Med;14:33, 2014 Jan 20.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Rhaponticum cathamoides (RC) is an endemic wild Siberian herb with marked medicinal properties that are still poorly understood. The aim of this study is to investigate the therapeutic potential of RC extract (ERC) compared to the effects of Glycyrrhiza glabra (EGG) and Punica granatum extracts (EPG) in a rat model with high-fat diet-(HFD)-induced signs of metabolic syndrome; therefore, this study addresses a significant global public health problem. METHODS: Six-month-old male Wistar Albino Glaxo rats were subjected to eight weeks of a standard diet (SD), HFD, or HFD in which ERC, EGG, or EPG powders were incorporated at 300 mg/kg/day. The serum lipid profile, corticosterone and cytokine concentrations, glucose tolerance, systolic blood pressure, triacylglycerol accumulation, and PPARα DNA-binding activities in the liver samples were determined. RESULTS: In contrast to EGG and EPG, an ERC supplement significantly reduced the weight of epididymal tissue (19.0%, p < 0.01) and basal serum glucose level (19.4%, p < 0.05). ERC improved glucose intolerance as well as dyslipidemia more efficiently than EGG and EPG. EGG but not ERC or EPG supplementation decreased systolic blood pressure by 12.0% (p < 0.05). All of the tested extracts reduced serum IL6 and corticosterone levels induced by HFD. However, the lowering effects of ERC consumption on the serum TNF-α level and its restoring effect on the adrenal corticosterone level significantly exceeded the improvements induced by EGG and EPG. ERC intake also reduced triacylglycerol accumulation and increased the PPARα DNA-binding activity in the liver more significantly than EGG and EPG. CONCLUSIONS: ERC powder supplementation improved glucose and lipid metabolism more significantly than EGG and EPG in rats fed on HFD, supporting the strategy of R. carthamoides use for safe relief of metabolic syndrome and its related disturbances such as inflammation, stress, and hepatic steatosis.
[Mh] Termos MeSH primário: Glicemia/metabolismo
Leuzea
Metabolismo dos Lipídeos/efeitos dos fármacos
Fígado/efeitos dos fármacos
Síndrome Metabólica/tratamento farmacológico
Fitoterapia
Extratos Vegetais/uso terapêutico
[Mh] Termos MeSH secundário: Animais
Pressão Sanguínea
Peso Corporal/efeitos dos fármacos
Dieta Hiperlipídica
Suplementos Nutricionais
Modelos Animais de Doenças
Fígado Gorduroso/sangue
Fígado Gorduroso/tratamento farmacológico
Fígado Gorduroso/etiologia
Intolerância à Glucose/sangue
Intolerância à Glucose/tratamento farmacológico
Glycyrrhiza
Fígado/metabolismo
Masculino
Síndrome Metabólica/sangue
Síndrome Metabólica/etiologia
PPAR alfa/metabolismo
Extratos Vegetais/farmacologia
Punicaceae
Ratos Wistar
Triglicerídeos/sangue
Fator de Necrose Tumoral alfa/sangue
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Blood Glucose); 0 (PPAR alpha); 0 (Plant Extracts); 0 (Triglycerides); 0 (Tumor Necrosis Factor-alpha)
[Em] Mês de entrada:1510
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140122
[St] Status:MEDLINE
[do] DOI:10.1186/1472-6882-14-33



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