Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.100.509 [Categoria DeCS]
Referências encontradas : 204 [refinar]
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[PMID]:28756155
[Au] Autor:Dogru E; Demirbas A; Altinsoy B; Duman F; Ocsoy I
[Ad] Endereço:Department of Analytical Chemistry, Faculty of Pharmacy, Erciyes University, 38039 Kayseri, Turkey; Nanotechnology Research Center, Erciyes University, Kayseri, 38039, Turkey.
[Ti] Título:Formation of Matricaria chamomilla extract-incorporated Ag nanoparticles and size-dependent enhanced antimicrobial property.
[So] Source:J Photochem Photobiol B;174:78-83, 2017 Sep.
[Is] ISSN:1873-2682
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Various concentrations of Matricaria chamomilla (M. chamomilla) flower extract was used for biosynthesis of Ag NPs with different sizes, 70±5 (Ag NP-1), 52±5 (Ag NP-1) and 37±4nm (Ag NP-3), and size-specific antimicrobial activity of them was evaluated towards Gram+ Staphylococcus aureus (S. aureus), Gram- Escherichia coli (E. coli) bacteria and Candida fungus albicans (C. albicans). We also examine the formation of Ag NPs as a function of the plant extract volume, Ag ion concentration (Ag ) and reaction time. M. chamomilla flower extract at 100ppm shows mild inhibitory effect by inhibiting growth of all target pathogens. The extract mediated Ag NPs even at low concentration (6.25ppm) caused reductions in cell densities of the pathogens. The potential reasons for the highly effective inhibitory activity of the extract mediated Ag NPs are: (1) synergistic effects due to combination of M. chamomile extract and Ag NP because Ag NP is an effective germicidal and M. chamomile plant itself shows mild inhibitory property, (2) high localized concentration of M. chamomile extract due to nano scale entrapment of it on surface of Ag NP and (3) size-specific antibacterial efficacy of Ag NP because small size increases the active surface area of Ag NP, which reacting bacterial cells and increases number of extract molecules anchored on the surface of Ag NP.
[Mh] Termos MeSH primário: Matricaria/química
Nanopartículas Metálicas/química
Tamanho da Partícula
Extratos Vegetais/química
Prata/química
Prata/farmacologia
[Mh] Termos MeSH secundário: Anti-Infecciosos/química
Anti-Infecciosos/farmacologia
Testes de Sensibilidade Microbiana
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Infective Agents); 0 (Plant Extracts); 3M4G523W1G (Silver)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171012
[Lr] Data última revisão:
171012
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170731
[St] Status:MEDLINE


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[PMID]:28704790
[Au] Autor:Bigagli E; Cinci L; D'Ambrosio M; Luceri C
[Ad] Endereço:Department of Neuroscience, Psychology, Drug Research and Child Health, NEUROFARBA, Section of Pharmacology and Toxicology, University of Florence, Viale G. Pieraccini 6, Florence, Italy.
[Ti] Título:Pharmacological activities of an eye drop containing Matricaria chamomilla and Euphrasia officinalis extracts in UVB-induced oxidative stress and inflammation of human corneal cells.
[So] Source:J Photochem Photobiol B;173:618-625, 2017 Aug.
[Is] ISSN:1873-2682
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Ultraviolet B (UVB) exposure is a risk factor for corneal damage resulting in oxidative stress, inflammation and cell death. The aim of this study was to investigate the potential protective effects of a commercial eye drop (Dacriovis™) containing Matricaria chamomilla and Euphrasia officinalis extracts on human corneal epithelial cells (HCEC-12) against UVB radiation-induced oxidative stress and inflammation as well as the underlying mechanisms. The antioxidant potential of the eye drops was evaluated by measuring the ferric reducing antioxidant power and the total phenolic content by Folin-Ciocalteu reagent. HCEC-12 cells were exposed to UVB radiation and treated with the eye drops at various concentrations. Cell viability, wound healing assay, reactive oxygen species (ROS) levels, protein and lipid oxidative damage and COX-2, IL-1ß, iNOS, SOD-2, HO-1 and GSS gene expression, were assessed. Eye drops were able to protect corneal epithelial cells from UVB-induced cell death and ameliorated the wound healing; the eye drops exhibited a strong antioxidant activity, decreasing ROS levels and protein and lipid oxidative damage. Eye drops also exerted anti-inflammatory activities by decreasing COX-2, IL-1ß, iNOS expression, counteracted UVB-induced GSS and SOD-2 expression and restored HO-1 expression to control levels. These findings suggest that an eye drop containing Matricaria chamomilla and Euphrasia officinalis extracts exerts positive effects against UVB induced oxidative stress and inflammation and may be useful in protecting corneal epithelial cells from UVB exposure.
[Mh] Termos MeSH primário: Anti-Inflamatórios/farmacologia
Euphrasia/química
Matricaria/química
Soluções Oftálmicas/farmacologia
Estresse Oxidativo/efeitos dos fármacos
Exsudatos de Plantas/química
Raios Ultravioleta
[Mh] Termos MeSH secundário: Anti-Inflamatórios/química
Antioxidantes/química
Linhagem Celular
Sobrevivência Celular/efeitos dos fármacos
Sobrevivência Celular/efeitos da radiação
Córnea/citologia
Córnea/efeitos dos fármacos
Córnea/metabolismo
Ciclo-Oxigenase 2/genética
Ciclo-Oxigenase 2/metabolismo
Euphrasia/metabolismo
Expressão Gênica/efeitos dos fármacos
Expressão Gênica/efeitos da radiação
Heme Oxigenase-1/metabolismo
Seres Humanos
Inflamação/patologia
Inflamação/prevenção & controle
Interleucina-1beta/genética
Interleucina-1beta/metabolismo
Matricaria/metabolismo
Óxido Nítrico Sintase Tipo II/genética
Óxido Nítrico Sintase Tipo II/metabolismo
Soluções Oftálmicas/química
Estresse Oxidativo/efeitos da radiação
Carbonilação Proteica/efeitos dos fármacos
Carbonilação Proteica/efeitos da radiação
Espécies Reativas de Oxigênio/metabolismo
Superóxido Dismutase/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Antioxidants); 0 (Interleukin-1beta); 0 (Ophthalmic Solutions); 0 (Plant Exudates); 0 (Reactive Oxygen Species); EC 1.14.13.39 (Nitric Oxide Synthase Type II); EC 1.14.14.18 (HMOX1 protein, human); EC 1.14.14.18 (Heme Oxygenase-1); EC 1.14.99.1 (Cyclooxygenase 2); EC 1.14.99.1 (PTGS2 protein, human); EC 1.15.1.1 (Superoxide Dismutase); EC 1.15.1.1 (superoxide dismutase 2)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171010
[Lr] Data última revisão:
171010
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170714
[St] Status:MEDLINE


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[PMID]:28124843
[Au] Autor:Park EH; Bae WY; Eom SJ; Kim KT; Paik HD
[Ad] Endereço:Department of Food Science and Biotechnology of Animal Resources, Konkuk University, Seoul 05029, Korea.
[Ti] Título:Improved antioxidative and cytotoxic activities of chamomile (Matricaria chamomilla) florets fermented by Lactobacillus plantarum KCCM 11613P.
[So] Source:J Zhejiang Univ Sci B;18(2):152-160, 2017 Feb..
[Is] ISSN:1862-1783
[Cp] País de publicação:China
[La] Idioma:eng
[Ab] Resumo:Antioxidative and cytotoxic effects of chamomile (Matricaria chamomilla) fermented by Lactobacillus plantarum were investigated to improve their biofunctional activities. Total polyphenol (TP) content was measured by the Folin-Denis method, and the antioxidant activities were assessed by the 1,1-diphenyl-2-picrylhydrazyl (DPPH) method and ß-carotene bleaching method. AGS, HeLa, LoVo, MCF-7, and MRC-5 (normal) cells were used to examine the cytotoxic effects by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium (MTT) assay. The TP content of fermented chamomile reduced from 21.75 to 18.76 mg gallic acid equivalent (mg GAE)/g, but the DPPH radical capturing activity of fermented chamomile was found to be 11.1% higher than that of nonfermented chamomile after 72 h of fermentation. Following the ß-carotene bleaching, the antioxidative effect decreased because of a reduction in pH during fermentation. Additionally, chamomile fermented for 72 h showed a cytotoxic effect of about 95% against cancer cells at 12.7 mg solid/ml of broth, but MRC-5 cells were significantly less sensitive against fermented chamomile samples. These results suggest that the fermentation of chamomile could be applied to develop natural antioxidative and anticancer products.
[Mh] Termos MeSH primário: Antioxidantes/química
Lactobacillus plantarum/metabolismo
Matricaria/química
Matricaria/microbiologia
Extratos Vegetais/química
[Mh] Termos MeSH secundário: Antineoplásicos/química
Linhagem Celular Tumoral
Fermentação
Radicais Livres/química
Células HeLa
Seres Humanos
Concentração de Íons de Hidrogênio
Células MCF-7
Estresse Oxidativo
Polifenóis/química
beta Caroteno/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Antioxidants); 0 (Free Radicals); 0 (Plant Extracts); 0 (Polyphenols); 01YAE03M7J (beta Carotene)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170713
[Lr] Data última revisão:
170713
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170127
[St] Status:MEDLINE
[do] DOI:10.1631/jzus.B1600063


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[PMID]:28109818
[Au] Autor:Avonto C; Rua D; Lasonkar PB; Chittiboyina AG; Khan IA
[Ad] Endereço:National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, The University of Mississippi, MS 38677, United States.
[Ti] Título:Identification of a compound isolated from German chamomile (Matricaria chamomilla) with dermal sensitization potential.
[So] Source:Toxicol Appl Pharmacol;318:16-22, 2017 Mar 01.
[Is] ISSN:1096-0333
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:German chamomile is one of the most popular herbal ingredients used in cosmetics and personal care products. Allergic skin reactions following topical application of German chamomile have been occasionally reported, although it is not fully understood which of the chemical constituents is responsible for this adverse effect. In the present work, three candidate sensitizers were isolated from German chamomile based on activity-guided fractionation of chamomile extracts tested using the in vitro KeratinoSens™ assay. The compounds were identified as the polyacetylene tonghaosu (1), and both trans- and cis-glucomethoxycinnamic acids (2 and 3). These three compounds were classified as non- to weakly reactive using in chemico methods; however, aged tonghaosu was found to be more reactive when compared to freshly isolated tonghaosu. The polyacetylene (1) constituent was determined to be chemically unstable, generating a small electrophilic spirolactone, 1,6-dioxaspiro[4.4]non-3-en-2-one (4), upon aging. This small lactone (4) was strongly reactive in both in chemico HTS- and NMR-DCYA methods and further confirmed as a potential skin sensitizer by Local Lymph Node Assay (LLNA).
[Mh] Termos MeSH primário: Flores
Matricaria/toxicidade
Extratos Vegetais/isolamento & purificação
Extratos Vegetais/toxicidade
Pele/efeitos dos fármacos
[Mh] Termos MeSH secundário: Administração Cutânea
Animais
Proliferação Celular/efeitos dos fármacos
Proliferação Celular/fisiologia
Camomila/toxicidade
Feminino
Camundongos
Extratos Vegetais/química
Pele/metabolismo
Testes Cutâneos/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Extracts)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170601
[Lr] Data última revisão:
170601
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170123
[St] Status:MEDLINE


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[PMID]:28056419
[Au] Autor:Jabri MA; Sakly M; Marzouki L; Sebai H
[Ad] Endereço:Laboratoire de Physiologie Intégrée, Faculté des Sciences de Bizerte, 7021 Zarzouna, Tunisie; Laboratoire de Physiologie Fonctionnelle et Valorisation des Bio-Ressources, Institut Supérieur de Biotechnologie de Béja, Avenue Habib Bourguiba, B.P. 382, 9000 Béja, Université de Jendouba, Tunisie. Elect
[Ti] Título:Chamomile (Matricaria recutita L.) decoction extract inhibits in vitro intestinal glucose absorption and attenuates high fat diet-induced lipotoxicity and oxidative stress.
[So] Source:Biomed Pharmacother;87:153-159, 2017 Mar.
[Is] ISSN:1950-6007
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:The present study aimed to investigate the inhibitory effect of chamomile decoction extract (CDE) on intestinal glucose absorption as well as its protective role against high fat diet (HFD)-induced obesity and lipotoxicity in rats. We used the Ussing chamber system to investigate the effect of CDE on intestinal transport of glucose. Male Wistar rats were fed HFD for six weeks to provoke obesity. CDE (100mg/kg, b.w. p.o.) has been per orally administered to HFD fed rats. Ex vivo, we found that CDE significantly and dose-dependently increased intestinal absorption of glucose. In vivo, HFD increased the body, liver and kidney weights, while CDE treatment showed a significant protective effects. High fat diet induced also a lipid profiles disorder and a disturbances in kidney and liver function parameters. Moreover liver and kidney lipotoxicity is accompanied by an oxidative stress status characterized by increased lipoperoxidation, depletion of antioxidant enzymes activity and non-enzymatic antioxidant (-SH groups and GSH) levels as well as increased levels of free iron, hydrogen peroxide (H O ) and calcium. However, treatment with CDE alleviated all the deleterious effects of HFD feed. These findings suggest that chamomile decoction extract can be used as functional beverage against obesity, hyperglycemia and hyperlipidemia.
[Mh] Termos MeSH primário: Dieta Hiperlipídica/efeitos adversos
Glucose/metabolismo
Peroxidação de Lipídeos/fisiologia
Matricaria
Estresse Oxidativo/fisiologia
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Animais
Camomila
Glucose/antagonistas & inibidores
Absorção Intestinal/efeitos dos fármacos
Absorção Intestinal/fisiologia
Peroxidação de Lipídeos/efeitos dos fármacos
Masculino
Camundongos
Técnicas de Cultura de Órgãos
Estresse Oxidativo/efeitos dos fármacos
Extratos Vegetais/isolamento & purificação
Ratos
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Extracts); IY9XDZ35W2 (Glucose)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170710
[Lr] Data última revisão:
170710
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170106
[St] Status:MEDLINE


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[PMID]:27693951
[Au] Autor:Guzelmeric E; Ristivojevic P; Vovk I; Milojkovic-Opsenica D; Yesilada E
[Ad] Endereço:Yeditepe University, Faculty of Pharmacy, Department of Pharmacognosy and Phytotherapy, Kayisdagi Cad., Atasehir, 34755 Istanbul, Turkey.
[Ti] Título:Quality assessment of marketed chamomile tea products by a validated HPTLC method combined with multivariate analysis.
[So] Source:J Pharm Biomed Anal;132:35-45, 2017 Jan 05.
[Is] ISSN:1873-264X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Chamomile tea composed of dried flower heads of Matricaria recutita L. (Asteraceae) is one of the most popular single ingredient herbal teas. Tea industries, spice shops or public bazaars are mostly supplied chamomile as a raw material via cultivation or through nature-picking. However, one of the drawbacks of nature-picking is adulteration. This could be either due to false authentication of the plant materials by ingenuous pickers or intentional/unintentional substitution with other flowers resembling to chamomile in appearance during harvesting. Therefore, quality control of raw chamomile materials before marketing should be carefully considered not only by quantification of apigenin 7-O-glucoside (active marker) but also by fingerprinting of chemical composition. This work presents both quantification of apigenin 7-O-glucoside and chemical fingerprinting of commercial chamomile tea products obtained from different food stores and spice shops by a validated HPTLC method. In addition, HPTLC profiles of investigated chamomile tea samples were compared with HPLC method stated in the European Pharmacopoeia and it was found that HPTLC method was superior to HPLC method in the field of adulteration confirmation. Therefore, fingerprint profiles performed on the silica gel 60 NH F s HPTLC plates combined with pattern recognition techniques of these marketed products were comparatively evaluated with wild and cultivar chamomile samples and also chamomile-like species from Asteraceae. Consequently, not chamomile tea bags but crude flowers sold on market were found to be adulterated with other plant materials.
[Mh] Termos MeSH primário: Camomila/química
Cromatografia Líquida de Alta Pressão/métodos
Análise de Alimentos/métodos
Chás de Ervas/análise
[Mh] Termos MeSH secundário: Apigenina/química
Asteraceae/química
Flores/química
Géis/química
Processamento de Imagem Assistida por Computador
Matricaria/química
Análise Multivariada
Extratos Vegetais/química
Controle de Qualidade
Dióxido de Silício/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Gels); 0 (Plant Extracts); 0 (Teas, Herbal); 7631-86-9 (Silicon Dioxide); 7OF2S66PCH (apigetrin); 7V515PI7F6 (Apigenin)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161004
[St] Status:MEDLINE


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[PMID]:26427789
[Au] Autor:Sharifi H; Minaie MB; Qasemzadeh MJ; Ataei N; Gharehbeglou M; Heydari M
[Ad] Endereço:Persian Medicine & Pharmacy Research Center, School of traditional Medicine, Tehran University of Medical Science, Tehran, Iran.
[Ti] Título:Topical use of Matricaria recutita L (Chamomile) Oil in the Treatment of Monosymptomatic Enuresis in Children: A Double-Blind Randomized Controlled Trial.
[So] Source:J Evid Based Complementary Altern Med;22(1):12-17, 2017 Jan.
[Is] ISSN:2156-5899
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:AIM: To evaluate the efficacy of topical use of Matricaria recutita L oil in the treatment of enuresis in children. METHODS: Eighty patients diagnosed as monosymptomatic nocturnal or daytime enuresis were allocated to receive Matricaria recutita L (chamomile) oil or placebo topically for 6 weeks in a double-blind randomized placebo-controlled trial with a parallel design. Patients were evaluated prior to and following 8 weeks of the intervention in terms of frequency of enuresis and any observed adverse events. RESULTS: The mean frequency of enuresis at the first, second, and third 2 weeks was lower in the intervention group compared with the placebo group, and the differences were statistically significant (P < .001, P = .03, and P < .001, respectively). There was no report of any adverse event in the study groups. CONCLUSION: The findings of this study showed that the topical use of (chamomile) oil can decrease the frequency of nocturia in children with monosymptomatic nocturnal or daytime enuresis.
[Mh] Termos MeSH primário: Matricaria/química
Enurese Noturna/tratamento farmacológico
Extratos Vegetais/uso terapêutico
[Mh] Termos MeSH secundário: Administração Tópica
Adolescente
Criança
Feminino
Seres Humanos
Masculino
Extratos Vegetais/administração & dosagem
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Plant Extracts)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170627
[Lr] Data última revisão:
170627
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151003
[St] Status:MEDLINE


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[PMID]:28025442
[Au] Autor:Goes P; Dutra CS; Lisboa MR; Gondim DV; Leitão R; Brito GA; Rego RO
[Ad] Endereço:Department of Pathology and Legal Medicine, Federal University of Ceará.
[Ti] Título:Clinical efficacy of a 1% Matricaria chamomile L. mouthwash and 0.12% chlorhexidine for gingivitis control in patients undergoing orthodontic treatment with fixed appliances.
[So] Source:J Oral Sci;58(4):569-574, 2016.
[Is] ISSN:1880-4926
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:This pilot study evaluated the clinical efficacy of a mouthwash containing 1% Matricaria chamomilla L. (MTC) extract in reducing gingival inflammation and plaque formation in patients undergoing orthodontic treatment with fixed appliances. This randomized, double-blind, placebo-controlled study enrolled a total of 30 males and females (age, 10-40 years) with fixed orthodontic appliances and a minimum of 20 natural teeth. The participants were allocated to three groups (n = 10 each) and asked to rinse with 15 mL of a placebo, 0.12% chlorhexidine (CHX), or 1% MTC mouthwash, immediately after brushing for 1 min, in the morning and evening, for 15 days. Data (mean ± SD) on visible plaque index (VPI) and gingival bleeding index (GBI) were recorded on days 1 and 15. The placebo group exhibited increases in VPI and GBI (10.2% and 23.1%, respectively) from day 1 to day 15. As compared with placebo, VPI and GBI significantly decreased in the MTC group (-25.6% and -29.9%, respectively) and the CHX group (-39.9% and -32.0%, respectively). In summary, MTC reduced biofilm accumulation and gingival bleeding in patients with gingivitis, probably because of its antimicrobial and anti-inflammatory activities.(J Oral Sci 58, 569-574, 2016).
[Mh] Termos MeSH primário: Clorexidina/administração & dosagem
Gengivite/prevenção & controle
Matricaria/química
Antissépticos Bucais
Aparelhos Ortodônticos
Extratos Vegetais/administração & dosagem
[Mh] Termos MeSH secundário: Adolescente
Adulto
Criança
Método Duplo-Cego
Feminino
Seres Humanos
Masculino
Placebos
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Mouthwashes); 0 (Placebos); 0 (Plant Extracts); R4KO0DY52L (Chlorhexidine)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171113
[Lr] Data última revisão:
171113
[Sb] Subgrupo de revista:D; IM
[Da] Data de entrada para processamento:161228
[St] Status:MEDLINE
[do] DOI:10.2334/josnusd.16-0280


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[PMID]:27912953
[Au] Autor:Tavakoli Ardakani M; Ghassemi S; Mehdizadeh M; Mojab F; Salamzadeh J; Ghassemi S; Hajifathali A
[Ad] Endereço:Department of Clinical Pharmacy, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Pharmaceutical sciences research center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
[Ti] Título:Evaluating the effect of Matricaria recutita and Mentha piperita herbal mouthwash on management of oral mucositis in patients undergoing hematopoietic stem cell transplantation: A randomized, double blind, placebo controlled clinical trial.
[So] Source:Complement Ther Med;29:29-34, 2016 Dec.
[Is] ISSN:1873-6963
[Cp] País de publicação:Scotland
[La] Idioma:eng
[Ab] Resumo:OBJECTIVES: To investigate the effects of Matricaria recutita and Mentha piperita on oral mucositis (OM) in patients undergoing hematopoietic stem cell transplantation (HSCT). DESIGN: Randomized double blind placebo controlled clinical trial. SETTING: Faculty of Pharmacy, Shahid Beheshti University of Medical Sciences, and Bone Marrow Transplantation Center at Taleghani Teaching Hospital, Tehran, Iran. PARTICIPANTS: Sixty patients undergoing HSCT were randomly assigned to two groups: placebo (n=33), and herbal mouthwash group (n=27). INTERVENTIONS: All patients received the mouthwash one week before HSCT and were instructed to use it three times daily for at least 30s. MAIN OUTCOME MEASURES: OM was graded using National Cancer Institute Common Toxicity Criteria (NCI-CTC) scale (grade 0-5). The Numerical Rating Scale (NRS: 0-10 scale) measured the severity of OM symptoms. RESULTS: The duration, maximum and average daily grade of OM were significantly reduced in the treatment group (P<0.05). The use of herbal mouthwash led to significant improvements in pain intensity (P=0.009), dryness (P=0.04) and dysphagia (P=0.009). Other significant results included: reduced need for complementary medications (P=0.03), narcotic analgesics (P=0.047), total parenteral nutrition (TPN) (P=0.02) and the duration of TPN (P=0.03). CONCLUSION: This study shows that patients receiving the herbal mouthwash experienced less complications and symptoms associated with OM. In summary, it seems that the use of our prepared herbal mouthwash is beneficial for patients undergoing HSCT.
[Mh] Termos MeSH primário: Medicamentos de Ervas Chinesas/uso terapêutico
Transplante de Células-Tronco Hematopoéticas/efeitos adversos
Matricaria/química
Mentha piperita/química
Antissépticos Bucais/uso terapêutico
Estomatite/tratamento farmacológico
[Mh] Termos MeSH secundário: Adulto
Método Duplo-Cego
Feminino
Seres Humanos
Masculino
[Pt] Tipo de publicação:CLINICAL TRIAL; JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Drugs, Chinese Herbal); 0 (Mouthwashes)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170404
[Lr] Data última revisão:
170404
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161204
[St] Status:MEDLINE


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[PMID]:27912875
[Au] Autor:Mao JJ; Xie SX; Keefe JR; Soeller I; Li QS; Amsterdam JD
[Ad] Endereço:Bendheim Center for Integrative Medicine, Memorial Sloan Kettering Cancer Center, 1429 First Avenue, New York, NY 10021, United States. Electronic address: maoj@mskcc.org.
[Ti] Título:Long-term chamomile (Matricaria chamomilla L.) treatment for generalized anxiety disorder: A randomized clinical trial.
[So] Source:Phytomedicine;23(14):1735-1742, 2016 Dec 15.
[Is] ISSN:1618-095X
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Generalized Anxiety Disorder (GAD) is one of the most common anxiety disorders treated in primary care, yet current therapies have limited efficacy and substantial side effects. PURPOSE: To evaluate long-term chamomile (Matricaria chamomilla L.) use for prevention of GAD symptom relapse. METHODS: Outpatients from primary care practices and local communities with a primary diagnosis of moderate-to-severe GAD were enrolled for this two-phase study at a large US academic medical center. During Phase 1, eligible participants received 12 weeks of open-label therapy with chamomile pharmaceutical grade extract 1500mg (500mg capsule 3 times daily). During Phase 2, treatment responders were randomized to either 26 weeks of continuation chamomile therapy or placebo in a double-blinded, placebo-substitution design. The primary outcome was time to relapse during continuation therapy, analyzed using Cox proportional hazards. Secondary outcomes included the proportion who relapsed, treatment-emergent adverse events, and vital sign changes. This study is registered at ClinicalTrials.gov, identifier NCT01072344. RESULTS: Between March 1, 2010, and June 30, 2015, we enrolled 179 participants. Of those, 93 (51.9%) were responders and agreed to continue in the double-blind randomized controlled trial. A numerically greater number of placebo-switched (n=12/47; 25.5%) versus chamomile-continuation (n = 7/46; 15.2%) participants relapsed during follow-up. Mean time to relapse was 11.4 ± 8.4 weeks for chamomile and 6.3 ± 3.9 weeks for placebo. Hazard of relapse was non-significantly lower for chamomile (hazard ratio, 0.52; 95% CI, 0.20-1.33; P = 0.16). During follow-up, chamomile participants maintained significantly lower GAD symptoms than placebo (P = 0.0032), with significant reductions in body weight (P = 0.046) and mean arterial blood pressure (P = 0.0063). Both treatments had similar low adverse event rates. CONCLUSIONS: Long-term chamomile was safe and significantly reduced moderate-to-severe GAD symptoms, but did not significantly reduce rate of relapse. Our limited sample size and lower than expected rate of placebo group relapse likely contributed to the non-significant primary outcome finding. Possible chamomile superiority over placebo requires further examination in large-scale studies.
[Mh] Termos MeSH primário: Ansiolíticos/uso terapêutico
Transtornos de Ansiedade/tratamento farmacológico
Ansiedade/tratamento farmacológico
Matricaria
Fitoterapia
Extratos Vegetais/uso terapêutico
[Mh] Termos MeSH secundário: Adulto
Ansiolíticos/farmacologia
Pressão Sanguínea/efeitos dos fármacos
Método Duplo-Cego
Feminino
Seres Humanos
Masculino
Meia-Idade
Extratos Vegetais/farmacologia
Recidiva
Fatores de Tempo
Resultado do Tratamento
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Anti-Anxiety Agents); 0 (Plant Extracts)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:171019
[Lr] Data última revisão:
171019
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161204
[Cl] Clinical Trial:ClinicalTrial
[St] Status:MEDLINE



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