Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.100.543 [Categoria DeCS]
Referências encontradas : 35 [refinar]
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[PMID]:25582489
[Au] Autor:Sollozo-Dupont I; Estrada-Camarena E; Carro-Juárez M; López-Rubalcava C
[Ad] Endereço:Departamento de Farmacobiología, Centro de Investigación y Estudios Avanzados (CINVESTAV), Calzada de los Tenorios 235, Col. Granjas Coapa, C.P. 14330 México, D.F., Mexico.
[Ti] Título:GABAA/benzodiazepine receptor complex mediates the anxiolytic-like effect of Montanoa tomentosa.
[So] Source:J Ethnopharmacol;162:278-86, 2015 Mar 13.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:ETHNOPHARMACOLOGICAL RELEVANCE: Montanoa tomentosa also named Cihuapatli is a native plant of Mexico that has been used in traditional medicine for the last five centuries mainly as a remedy for reproductive impairments. However, there are reports indicating that this plant was also consumed by Mexican ancient people for its relaxing properties. In order to corroborate this information, the present study was conducted to evaluate the effect of Montanoa tomentosa lyophilisate (MT) on rat׳s anxiety-like behavior and to analyze its mechanism of action. MATERIALS AND METHODS: The anxiolytic-like action of MT (1.5, 3.0, 6.0 and 12.0 mg/kg) was investigated in male Wistar rats tested in three animal models of anxiety: the burying behavior, the elevated plus maze and the hole-board tests. As a positive control, the anti-anxiety effects of different doses of the selective GABAA receptor agonist muscimol were also analyzed. In order to evaluate the participation of the GABAA and oxytocin receptors in the anxiolytic-like actions of MT, the GABAA receptors blockers picrotoxin (0.25 and 0.50 mg/kg), bicuculline (2.0 mg/kg) and flumazenil (5.00 and 10.0 mg/kg), the neurosteroid inhibitor finasteride (50.0 and 100 mg/kg) and the oxytocin receptor antagonist atosiban (0.25 µg) were used. Finally, to evaluate general activity, and motor coordination, the open field and rota-rod tests were used. RESULTS: MT at 3.0 mg/kg showed anxiolytic-like effects in the three anxiety paradigms without affecting reactivity, general motor activity or motor coordination; however, at higher doses sedative effects were observed. Picrotoxin (0.25 and 0.50 mg/kg), flumazenil (10.0 mg/kg) and finasteride (100 mg/kg) antagonized the anxiolytic-like actions of MT in the burying behavior test. In the plus maze and hole-board tests bicuculline (2.0 mg/kg) blocked the effects of the plant as well. Atosiban (0.25 µg) did not antagonize the anxiolytic-like actions of MT. CONCLUSIONS: The results corroborate the anxiolytic-like actions of Montanoa tomentosa and suggest that this effect is mediated through GABAA receptors but not oxytocin receptors.
[Mh] Termos MeSH primário: Ansiolíticos/farmacologia
Ansiedade/tratamento farmacológico
Montanoa/química
Extratos Vegetais/farmacologia
Receptores de GABA-A/metabolismo
[Mh] Termos MeSH secundário: Animais
Ansiolíticos/química
Comportamento Animal/efeitos dos fármacos
Relação Dose-Resposta a Droga
Regulação da Expressão Gênica
Masculino
Muscimol/administração & dosagem
Muscimol/farmacologia
Extratos Vegetais/administração & dosagem
Extratos Vegetais/química
Ratos
Ratos Wistar
Receptores de GABA-A/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Anxiety Agents); 0 (Plant Extracts); 0 (Receptors, GABA-A); 2763-96-4 (Muscimol)
[Em] Mês de entrada:1603
[Cu] Atualização por classe:150217
[Lr] Data última revisão:
150217
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150114
[St] Status:MEDLINE


  2 / 35 MEDLINE  
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[PMID]:24800255
[Au] Autor:Rodríguez-Landa JF; Vicente-Serna J; Rodríguez-Blanco LA; Rovirosa-Hernández Mde J; García-Orduña F; Carro-Juárez M
[Ad] Endereço:Instituto de Neuroetología, Universidad Veracruzana, Avenida Dr. Luis Castelazo s/n, Colonia Industrial Ánimas, 91001 Xalapa, VER, Mexico ; Facultad de Química Farmacéutica Biológica, Universidad Veracruzana, 91190 Xalapa, VER, Mexico.
[Ti] Título:Montanoa frutescens and Montanoa grandiflora extracts reduce anxiety-like behavior during the metestrus-diestrus phase of the ovarian cycle in Wistar rats.
[So] Source:Biomed Res Int;2014:938060, 2014.
[Is] ISSN:2314-6141
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In previous studies, the anxiolytic-like effects of Montanoa tomentosa and Montanoa frutescens were reported in male rats, but the potential anxiolytic-like effects of Montanoa plants during the different phases of the ovarian cycle in rats remain to be explored. The anxiolytic-like effects of the aqueous crude extracts of M. frutescens (25 and 50 mg/kg) and M. grandiflora (25 and 50 mg/kg) in the elevated plus maze were investigated in Wistar rats during the estrous cycle and compared with 2 mg/kg diazepam as a reference anxiolytic drug. To investigate any motor effect (i.e., hyperactivity, no changes, or hypoactivity) associated with the treatments, the rats were evaluated in the open field test. The M. frutescens (25 and 50 mg/kg) and M. grandiflora (50 mg/kg) extracts exerted anxiolytic-like effects during the metestrus-diestrus phase, similar to diazepam, without disrupting spontaneous motor activity. No significant effects of the extracts were detected in either behavioral test during the proestrus-estrus phase, whereas diazepam produced motor hypoactivity in the open field test. These results indicate that the M. frutescens and M. grandiflora extracts possess anxiolytic-like effects that depend on the ovarian cycle phase, supporting the Mexican ancient medicinal use of these plants to ameliorate anxiety disorders.
[Mh] Termos MeSH primário: Ansiolíticos/farmacologia
Ansiedade/tratamento farmacológico
Diestro/fisiologia
Metestro/fisiologia
Montanoa/química
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Animais
Ansiolíticos/química
Ansiolíticos/uso terapêutico
Comportamento Animal/efeitos dos fármacos
Feminino
Aprendizagem em Labirinto/efeitos dos fármacos
Extratos Vegetais/química
Extratos Vegetais/uso terapêutico
Ratos
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Anxiety Agents); 0 (Plant Extracts)
[Em] Mês de entrada:1412
[Cu] Atualização por classe:150806
[Lr] Data última revisão:
150806
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140507
[St] Status:MEDLINE
[do] DOI:10.1155/2014/938060


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[PMID]:24647378
[Au] Autor:Carro-Juárez M; Franco MÁ; Rodríguez-Peña Mde L
[Ad] Endereço:Universidad Autónoma de Tlaxcala, Tlaxcala, México.
[Ti] Título:Increase of the ejaculatory potency by the systemic administration of aqueous crude extracts of cihuapatli (Montanoa genus) plants in spinal male rats.
[So] Source:J Evid Based Complementary Altern Med;19(1):43-50, 2014 Jan.
[Is] ISSN:2156-5899
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In the present study, evidence on the aphrodisiac activity of Montanoa frutescens and Montanoa grandiflora and a comparison with the aphrodisiac activity of Montanoa tomentosa is presented. By using the fictive ejaculation model in spinal male rats, electromyographic recordings of the genital motor pattern of ejaculation were obtained in the bulbospongiosus muscles and analyzed after the intravenous injection of aqueous crude extracts of Montanoa tomentosa, Montanoa frutescens, and Montanoa grandiflora. Results showed that the systemic administration of the aqueous crude extracts of Montanoa plants elicits a significant increase in the ejaculatory capacity of spinal male rats with very robust ejaculatory motor patterns that included the expression of tonic penile erections and penile movements and the potent expulsion of urethral contents. In conclusion, Montanoa frutescens and Montanoa grandiflora increase the ejaculatory potency with aphrodisiac activity similar to Montanoa tomentosa.
[Mh] Termos MeSH primário: Afrodisíacos/administração & dosagem
Ejaculação/efeitos dos fármacos
Montanoa/química
Extratos Vegetais/administração & dosagem
Disfunções Sexuais Fisiológicas/tratamento farmacológico
[Mh] Termos MeSH secundário: Animais
Seres Humanos
Masculino
Ratos
Ratos Wistar
Disfunções Sexuais Fisiológicas/fisiopatologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Aphrodisiacs); 0 (Plant Extracts)
[Em] Mês de entrada:1411
[Cu] Atualização por classe:140320
[Lr] Data última revisão:
140320
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140321
[St] Status:MEDLINE
[do] DOI:10.1177/2156587213510006


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[PMID]:22885072
[Au] Autor:Carro-Juárez M; Rodríguez-Landa JF; Rodríguez-Peña Mde L; Rovirosa-Hernández Mde J; García-Orduña F
[Ad] Endereço:Laboratorio de Comportamiento Reproductivo, Escuela de Medicina Veterinaria y Zootecnia, Universidad Autónoma de Tlaxcala, Tlaxcala CP. 90000, Tlaxcala, México.
[Ti] Título:The aqueous crude extract of Montanoa frutescens produces anxiolytic-like effects similarly to diazepam in Wistar rats: involvement of GABAA receptor.
[So] Source:J Ethnopharmacol;143(2):592-8, 2012 Sep 28.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:ETHNOPHARMACOLOGICAL RELEVANCE: Cihuapatli is the Nahuatl name assigned to some medicinal plants grouped in the genus Montanoa, where Montanoa frutescens (Family: Asteraceae, Tribe: Heliantheae) is included. The crude extract from these plants has been used for centuries in the Mexican traditional medicine as a remedy for reproductive impairments and mood disorders. Experimental studies have systematically corroborated the traditional use of cihuapatli on reproductive impairments and sexual motivation, however, the effect on mood and "nervous" disorders, remains to be explored. MATERIALS AND METHODS: The anxiolytic-like effect of aqueous crude extract of M. frutescens (25, 50 and 75 mg/kg) was investigated in male Wistar rats evaluated in the elevated plus-maze and compared with several doses of diazepam (1, 2 and 4 mg/kg) as a reference anxiolytic drug. Picrotoxin (1 mg/kg), a noncompetitive antagonist of the GABA(A) receptor, was used in experimental procedures to evaluate if this receptor could be involved in the anxiolytic-like effects produced by M. frutescens. To discard hypoactivity, hyperactivity, or no changes associated with treatments, which could interfere with the behavioral activity in the elevated plus-maze, rats were subjected to the open field test. RESULTS: M. frutescens at 50 mg/kg showed anxiolytic-like activity similarly to 2 mg/kg of diazepam, without disrupts in general motor activity. The anxiolytic-like effect of M. frutescens detected in the elevated plus-maze was blocked by picrotoxin, indicating that GABA(A) receptors are involved in the modulation of this effect. CONCLUSIONS: The results corroborate the use of M. frutescens in folk Mexican ethnomedicine as a potential anxiolytic agent and suggest that this effect is mediated by the GABA(A) receptors. Additionally, some sedative effects with high doses of M. frutescens were detected in the present study.
[Mh] Termos MeSH primário: Ansiolíticos/uso terapêutico
Ansiedade/tratamento farmacológico
Montanoa
Extratos Vegetais/uso terapêutico
Receptores de GABA-A/fisiologia
[Mh] Termos MeSH secundário: Animais
Ansiolíticos/farmacologia
Ansiedade/fisiopatologia
Comportamento Animal/efeitos dos fármacos
Diazepam/farmacologia
Diazepam/uso terapêutico
Antagonistas GABAérgicos/farmacologia
Masculino
Atividade Motora/efeitos dos fármacos
Fitoterapia
Picrotoxina/farmacologia
Extratos Vegetais/farmacologia
Ratos
Ratos Wistar
Água/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Anxiety Agents); 0 (GABA Antagonists); 0 (Plant Extracts); 0 (Receptors, GABA-A); 059QF0KO0R (Water); 124-87-8 (Picrotoxin); Q3JTX2Q7TU (Diazepam)
[Em] Mês de entrada:1301
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:120814
[St] Status:MEDLINE
[do] DOI:10.1016/j.jep.2012.07.022


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[PMID]:19581023
[Au] Autor:Villa-Ruano N; Betancourt-Jiménez MG; Lozoya-Gloria E
[Ad] Endereço:Departamento de Ingeniería Genética, Centro de Investigación y de Estudios Avanzados del IPN, Unidad Irapuato, Km 9.6 Libramiento Norte Carretera Irapuato-León, P.O. Box 629, C.P. 36821 Irapuato, Guanajuato, México.
[Ti] Título:Biosynthesis of uterotonic diterpenes from Montanoa tomentosa (zoapatle).
[So] Source:J Plant Physiol;166(18):1961-7, 2009 Dec 15.
[Is] ISSN:1618-1328
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Montanoa tomentosa (zoapatle) is a Central American plant used in Mexico in traditional herbal medicine to ease childbirth labor and to cure certain female disorders. Recently, crude extracts of M. tomentosa have been reported to have an aphrodisiacal effect on male rats. The bioactive molecules are the uterotonic diterpenes kaurenoic acid (KA), grandiflorenic acid (GF), and monoginoic acid (MO). Roots of M. tomentosa contain all three diterpenes, whereas in leaves only kaurenoic and GF are present. However, despite the pharmacological importance of these compounds, specific information about their biosynthesis and localization in the plant is not available. In this investigation, we followed the metabolic transformation of a tritium-labeled diterpene-precursor via geranylgeranyl diphosphate into each of the three diterpenes. Inhibitors of gibberellin biosynthesis were used to elucidate the sequence of conversion of the intermediates. Our results suggest the biosynthetic conversion of KA into GF by a putative cytochrome P450-like desaturase. Partial characterization of the enzyme revealed that it requires NADPH and O2 but is inhibited by 50 microM paclobutrazol, suggesting a cytochrome P450 desaturase like enzyme (EC 1.14.14.-). Optimal reaction conditions are 32 degrees C and a pH of 7.6, respectively. Apparent kinetics parameters for KA gave a K(m,app) of 36.31 microM, and a V(max, app) of 13.6 nmol KA mg(1)protein h(-1). Based on the data presented, a putative biosynthetic pathway is proposed for the uterotonic diterpenes of M. tomentosa.
[Mh] Termos MeSH primário: Diterpenos/metabolismo
Montanoa/metabolismo
[Mh] Termos MeSH secundário: Clormequat
Ciclopropanos
Giberelinas/antagonistas & inibidores
Microssomos/metabolismo
Oxirredutases atuantes sobre Doadores de Grupo CH-CH/metabolismo
Reguladores de Crescimento de Planta
Folhas de Planta/metabolismo
Proteínas de Plantas/metabolismo
Raízes de Plantas/metabolismo
Plantas Medicinais/metabolismo
Fosfatos de Poli-Isoprenil/metabolismo
Quinonas
Triazóis
Trítio
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Cyclopropanes); 0 (Diterpenes); 0 (Gibberellins); 0 (Plant Growth Regulators); 0 (Plant Proteins); 0 (Polyisoprenyl Phosphates); 0 (Quinones); 0 (Triazoles); 0 (monoginoic acid); 10028-17-8 (Tritium); 22338-67-6 (grandiflorenic acid); 6730-83-2 (kaurenoic acid); 6PLV42R3ZA (paclobutrazol); 8SUZ1123XX (Chlormequat); EC 1.3.- (Oxidoreductases Acting on CH-CH Group Donors); EC 1.3.- (kaurenoic acid desaturase, Montanoa tomentosa); N21T0D88LX (geranylgeranyl pyrophosphate); Q89W563T9J (trinexapac-ethyl)
[Em] Mês de entrada:1002
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:090708
[St] Status:MEDLINE
[do] DOI:10.1016/j.jplph.2009.06.004


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[PMID]:18824221
[Au] Autor:Robles-Zepeda RE; Lozoya-Gloria E; López MG; Villarreal ML; Ramírez-Chávez E; Molina-Torres J
[Ad] Endereço:Departamento de Ciencias Químico Biológicas, Universidad de Sonora, Hermosillo, Sonora, Mexico.
[Ti] Título:Montanoa tomentosa glandular trichomes containing kaurenoic acids chemical profile and distribution.
[So] Source:Fitoterapia;80(1):12-7, 2009 Jan.
[Is] ISSN:1873-6971
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Montanoa tomentosa has been used in traditional medicine in Mexico to treat diverse female health disorders; it is particularly useful in inducing childbirth. Microscopic analysis of leaf surfaces of M. tomentosa revealed the presence of glandular trichomes. The chemical profile and distribution of glandular trichomes from different developmental stages of M. tomentosa leaves were investigated. Two diterpenic acids, kaurenoic and grandiflorenic were detected in glandular trichomes through the glandular microsampling technique and GC/MS analysis. In the glandular trichomes of the leaves also up to twenty-six volatile terpenes were identified, where beta-eudesmol and valencene were the most abundant terpenes.
[Mh] Termos MeSH primário: Diterpenos/análise
Montanoa/química
Terpenos/análise
[Mh] Termos MeSH secundário: Diterpenos/química
Montanoa/anatomia & histologia
Folhas de Planta/anatomia & histologia
Folhas de Planta/química
Sesquiterpenos/análise
Sesquiterpenos de Eudesmano/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Diterpenes); 0 (Sesquiterpenes); 0 (Sesquiterpenes, Eudesmane); 0 (Terpenes); 22338-67-6 (grandiflorenic acid); 473-15-4 (beta-eudesmol); 6730-83-2 (kaurenoic acid); 96H21P91IG (valencene)
[Em] Mês de entrada:0904
[Cu] Atualização por classe:121115
[Lr] Data última revisão:
121115
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:081001
[St] Status:MEDLINE
[do] DOI:10.1016/j.fitote.2008.09.002


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[PMID]:16442762
[Au] Autor:Carro-Juárez M; Lobatón I; Benítez O; Espíritu A
[Ad] Endereço:Laboratorio de Comportamiento Reproductivo, Escuela de Medicina Veterinaria y Zootecnia, Universidad Autónoma de Tlaxcala, CP 90000, AP 484, Col. Centro, Tlaxcala, Mexico. miguel_carro@hotmail.com
[Ti] Título:Pro-ejaculatory effect of the aqueous crude extract of cihuapatli (Montanoa tomentosa) in spinal male rats.
[So] Source:J Ethnopharmacol;106(1):111-6, 2006 Jun 15.
[Is] ISSN:0378-8741
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:In the present study, the pro-sexual effect of the cihuapatli (Montanoa tomentosa) and its possible pro-ejaculatory properties in spinal male rats were examined. Systemic administration of the aqueous crude extracts of Montanoa tomentosa exerted a pro-ejaculatory effect and produced an increase in the number of discharges in the ejaculatory motor patterns in the spinal rats. The cihuapatli-induced ejaculatory responses included the expression of penile erections and penile movements and the potent expulsion of urethral contents and in some cases the expulsion of seminal plugs. The cihuapatli-induced ejaculatory motor patterns were similar to that obtained after systemic oxytocin. Cihuapatli- and oxytocin-induced ejaculatory motor responses and the penile erections and movements were abolished by the pre-treatment with hexamethonium, a selective oxytocin antagonist. Present data show that the cihuapatli extract acts directly at the spinal system in charge of the expression of the ejaculatory motor patterns and suggest that the aqueous crude extract exerts its aphrodisiacs properties by increasing sexual potency acting as an oxytocic agent.
[Mh] Termos MeSH primário: Ejaculação
Genitália Masculina/fisiologia
Montanoa/metabolismo
Extratos Vegetais/farmacologia
Comportamento Sexual Animal/efeitos dos fármacos
Medula Espinal/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Ejaculação/efeitos dos fármacos
Ejaculação/fisiologia
Feminino
Genitália Masculina/inervação
Masculino
Montanoa/química
Extratos Vegetais/isolamento & purificação
Ratos
Ratos Wistar
Comportamento Sexual Animal/fisiologia
Medula Espinal/fisiologia
Água
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Extracts); 059QF0KO0R (Water)
[Em] Mês de entrada:0611
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:060131
[St] Status:MEDLINE


  8 / 35 MEDLINE  
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[PMID]:15703746
[Au] Autor:Borchert R; Renner SS; Calle Z; Navarrete D; Tye A; Gautier L; Spichiger R; von Hildebrand P
[Ad] Endereço:Biology Division, University of Kansas, Lawrence, Kansas 66045-7534, USA. borchert@ku.edu
[Ti] Título:Photoperiodic induction of synchronous flowering near the Equator.
[So] Source:Nature;433(7026):627-9, 2005 Feb 10.
[Is] ISSN:1476-4687
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:In tropical rainforests, 30-65% of tree species grow at densities of less than one individual per hectare. At these low population densities, successful cross-pollination relies on synchronous flowering. In rainforests with low climatic seasonality, photoperiodic control is the only reliable mechanism for inducing synchronous flowering. This poses a problem because there is no variation in day length at the Equator. Here we propose a new mechanism of photoperiodic timekeeping based on the perception of variation in sunrise or sunset time, which explains and predicts the annually repeated, staggered, synchronous and bimodal flowering of many tree species in Amazonian rainforests near the Equator.
[Mh] Termos MeSH primário: Flores/fisiologia
Geografia
Fotoperíodo
[Mh] Termos MeSH secundário: Colômbia
Costa Rica
Flores/efeitos da radiação
Melastomataceae/fisiologia
Melastomataceae/efeitos da radiação
Montanoa/fisiologia
Montanoa/efeitos da radiação
Reprodução/fisiologia
Reprodução/efeitos da radiação
Estações do Ano
Luz Solar
Fatores de Tempo
Árvores/fisiologia
Árvores/efeitos da radiação
Clima Tropical
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:0503
[Cu] Atualização por classe:050210
[Lr] Data última revisão:
050210
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:050211
[St] Status:MEDLINE


  9 / 35 MEDLINE  
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[PMID]:15159142
[Au] Autor:Carro-Juárez M; Cervantes E; Cervantes-Méndez M; Rodríguez-Manzo G
[Ad] Endereço:Laboratorio de Comportamiento Reproductivo, Escuela de Medicina Veterinaria y Zootecnia, Universidad Autónoma de Tlaxcala, CP 90000, AP. 484, Tlaxcala, Mexico. miguel_carro@hotmail.com.mx
[Ti] Título:Aphrodisiac properties of Montanoa tomentosa aqueous crude extract in male rats.
[So] Source:Pharmacol Biochem Behav;78(1):129-34, 2004 May.
[Is] ISSN:0091-3057
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Cihuapatli, the Mexican zoapatle (Montanoa tomentosa) has an extensive ethnomedical history of use as a traditional remedy for reproductive impairments. During the study of the ejaculatory function in rats and by testing a set of Mexican plants with medicinal properties, we observed that crude extracts of M. tomentosa facilitated ejaculation. Thus, we decided to analyze the possibility that this plant possessed sexual stimulant properties. To that aim, copulatory behavior of sexually active male rats receiving doses of 38, 75 and 150 mg/kg of the aqueous crude extract of M. tomentosa, as it is prepared in traditional medicine, was assessed. In addition, we evaluated the effect of the 75-mg/kg dose of the extract on males with anesthetization of the genital area and on sexual behavior of sexually inactive male rats (noncopulators). Results showed that acute oral administration of crude extracts of M. tomentosa facilitates expression of sexual behavior in sexually active male rats, significantly increases mounting behavior in genitally anesthetized animals and induces the expression of sexual behavior in noncopulating males. Altogether, these data reveal a facilitatory action of this extract on sexual activity and particularly on sexual arousal. Present findings provide experimental evidence that the crude extract preparation of M. tomentosa, used as a traditional remedy, possesses aphrodisiac properties.
[Mh] Termos MeSH primário: Afrodisíacos/farmacologia
Montanoa
Comportamento Sexual Animal/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Afrodisíacos/isolamento & purificação
Feminino
Flores
Masculino
Extratos Vegetais/isolamento & purificação
Extratos Vegetais/farmacologia
Folhas de Planta
Ratos
Ratos Wistar
Comportamento Sexual Animal/fisiologia
Água/farmacologia
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Aphrodisiacs); 0 (Plant Extracts); 059QF0KO0R (Water)
[Em] Mês de entrada:0501
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:040526
[St] Status:MEDLINE


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[PMID]:15120380
[Au] Autor:Plovanich AE; Panero JL
[Ad] Endereço:Department of Plant Biology, Michigan State University, East Lansing, MI 48824, USA.
[Ti] Título:A phylogeny of the ITS and ETS for Montanoa (Asteraceae: Heliantheae).
[So] Source:Mol Phylogenet Evol;31(3):815-21, 2004 Jun.
[Is] ISSN:1055-7903
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A phylogeny of the genus Montanoa based on the internal transcribed spacer (ITS) and the external transcribed spacer (ETS) is presented. Each of the two clades revealed by the Bayesian and parsimony analyses has approximately half of the number of species in the genus. One lineage is composed mostly of central and southern Mexican species whereas the other lineage contains those species endemic to Mesoamerica and South America. The molecular phylogeny is compared to previous phylogenetic hypotheses based on morphological characters. Key features in the structure of the capitulum such as pale morphology, heavily used in the past to construct hypotheses of relationship within the genus, are viewed as of minimal value to circumscribe natural groups. The relationships of Montanoa to other genera in the Heliantheae are briefly discussed.
[Mh] Termos MeSH primário: Asteraceae/genética
DNA Intergênico/genética
DNA de Plantas
Genes de Plantas
Montanoa/genética
[Mh] Termos MeSH secundário: Variação Genética
Filogenia
Especificidade da Espécie
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Nm] Nome de substância:
0 (DNA, Intergenic); 0 (DNA, Plant)
[Em] Mês de entrada:0406
[Cu] Atualização por classe:081121
[Lr] Data última revisão:
081121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:040504
[St] Status:MEDLINE



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