Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.100.562 [Categoria DeCS]
Referências encontradas : 22 [refinar]
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  1 / 22 MEDLINE  
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[PMID]:27871974
[Au] Autor:Formisano C; Sanna C; Ballero M; Chianese G; Sirignano C; Rigano D; Millán E; Muñoz E; Taglialatela-Scafati O
[Ad] Endereço:Department of Pharmacy, University of Naples Federico II, Via D. Montesano, 49, I-80131 Naples, Italy.
[Ti] Título:Anti-inflammatory sesquiterpene lactones from Onopordum illyricum L. (Asteraceae), an Italian medicinal plant.
[So] Source:Fitoterapia;116:61-65, 2017 Jan.
[Is] ISSN:1873-6971
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Onopordum illyricum L. is a medicinal plant used in the Mediterranean area as antipyretic for the treatment of respiratory and urinary inflammations and to treat skin ulcers. Repeated chromatographic purification of O. illyricum aerial parts led to the isolation of six known sesquiterpenes, which were evaluated for the inhibition of the pro-inflammatory transcription factors NF-κB and STAT3 and for the activation of the transcription factor Nrf2, which regulates the cellular antioxidant response. Structure-activity relationships were interpreted by the NMR-based cysteamine assay. The sesquiterpene lactone vernomelitensin significantly inhibited NF-κB and STAT3, showing also a significant Nrf2 activation. Accordingly, the cysteamine assay selected vernomelitensin as the most reactive of the isolated sesquiterpenes, identifying the α,ß-unsaturated aldehyde moiety as responsible for the higher (re)activity.
[Mh] Termos MeSH primário: Anti-Inflamatórios/farmacologia
Lactonas/farmacologia
Onopordum/química
Plantas Medicinais/química
Sesquiterpenos/farmacologia
[Mh] Termos MeSH secundário: Animais
Anti-Inflamatórios/isolamento & purificação
Células HeLa
Seres Humanos
Itália
Lactonas/isolamento & purificação
Camundongos
Estrutura Molecular
NF-kappa B/antagonistas & inibidores
Células NIH 3T3
Componentes Aéreos da Planta/química
Fator de Transcrição STAT3/antagonistas & inibidores
Sesquiterpenos/isolamento & purificação
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Lactones); 0 (NF-kappa B); 0 (STAT3 Transcription Factor); 0 (Sesquiterpenes); 0 (vernomelitensin); 19889-00-0 (onopordopicrin)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170118
[Lr] Data última revisão:
170118
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161123
[St] Status:MEDLINE


  2 / 22 MEDLINE  
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[PMID]:27604753
[Au] Autor:Álvarez-Torrellas S; Muñoz M; Zazo JA; Casas JA; García J
[Ad] Endereço:Grupo de Catálisis y Procesos de Separación (CyPS), Departamento de Ingeniería Química, Facultad de Ciencias Químicas, Universidad Complutense de Madrid, Avda. Complutense s/n, 28040, Madrid, Spain. Electronic address: satorrellas@ucm.es.
[Ti] Título:Synthesis of high surface area carbon adsorbents prepared from pine sawdust-Onopordum acanthium L. for nonsteroidal anti-inflammatory drugs adsorption.
[So] Source:J Environ Manage;183:294-305, 2016 Dec 01.
[Is] ISSN:1095-8630
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Chemically activated carbon materials prepared from pine sawdust-Onopordum acanthium L. were studied for the removal of diclofenac and naproxen from aqueous solution. Several carbons, using different proportions of precursors were obtained (carbon C1 to carbon C5) and the chemical modification by liquid acid and basic treatments of C1 were carried out. The textural properties of the carbons, evaluated by N2 adsorption-desorption isotherms, revealed that the treatments with nitric acid and potassium hydroxide dramatically reduced the specific surface area and the pore volume of the carbon samples. The surface chemistry characterization, made by thermal programmed decomposition studies, determination of isoelectric point and Boehm's titration, showed the major presence of lactone and phenol groups on the activated carbons surface, being higher the content when the acidic strength of the carbon increased. Diclofenac and naproxen kinetic data onto C1 carbon followed pseudo-second order model. The adsorption equilibrium isotherms of C1 and the modified carbons were well described by both Sips and GAB isotherm equations. The highest adsorption capacity was found for naproxen onto C1 activated carbon, 325 mg g(-1), since the liquid acid and basic functionalization of the carbon led to a severe decreasing in the adsorption removal of the target compounds.
[Mh] Termos MeSH primário: Anti-Inflamatórios não Esteroides/isolamento & purificação
Carbono/análise
Poluentes Ambientais/isolamento & purificação
Onopordum/química
Pinus/química
Madeira/química
[Mh] Termos MeSH secundário: Adsorção
Carvão Vegetal/química
Concentração de Íons de Hidrogênio
Hidróxidos/química
Lactonas/análise
Modelos Teóricos
Ácido Nítrico/química
Fenol/análise
Compostos de Potássio/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents, Non-Steroidal); 0 (Environmental Pollutants); 0 (Hydroxides); 0 (Lactones); 0 (Potassium Compounds); 16291-96-6 (Charcoal); 339NCG44TV (Phenol); 411VRN1TV4 (Nitric Acid); 7440-44-0 (Carbon); WZH3C48M4T (potassium hydroxide)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170926
[Lr] Data última revisão:
170926
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160909
[St] Status:MEDLINE


  3 / 22 MEDLINE  
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[PMID]:26901188
[Au] Autor:Molnár J; Szebeni GJ; Csupor-Löffler B; Hajdú Z; Szekeres T; Saiko P; Ocsovszki I; Puskás LG; Hohmann J; Zupkó I
[Ad] Endereço:Department of Pharmacodynamics and Biopharmacy, University of Szeged, H-6720 Szeged, Hungary. molnar.judit@pharm.u-szeged.hu.
[Ti] Título:Investigation of the Antiproliferative Properties of Natural Sesquiterpenes from Artemisia asiatica and Onopordum acanthium on HL-60 Cells in Vitro.
[So] Source:Int J Mol Sci;17(2):83, 2016 Feb 17.
[Is] ISSN:1422-0067
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Plants and plant extracts play a crucial role in the research into novel antineoplastic agents. Four sesquiterpene lactones, artecanin (1), 3ß-chloro-4α,10α-dihydroxy-1α,2α-epoxy-5α,7αH-guaia-11(13)-en-12,6α-olide (2), iso-seco-tanapartholide 3-O-methyl ether (3) and 4ß,15-dihydro-3-dehydrozaluzanin C (4), were isolated from two traditionally used Asteraceae species (Onopordum acanthium and Artemisia asiatica). When tested for antiproliferative action on HL-60 leukemia cells, these compounds exhibited reasonable IC50 values in the range 3.6-13.5 µM. Treatment with the tested compounds resulted in a cell cycle disturbance characterized by increases in the G1 and G2/M populations, while there was a decrease in the S phase. Additionally, 1-3 elicited increases in the hypodiploid (subG1) population. The compounds elicited concentration-dependent chromatin condensation and disruption of the membrane integrity, as revealed by Hoechst 33258-propidium staining. Treatment for 24 h resulted in significant increases in activity of caspases-3 and -9, indicating that the tested sesquiterpenes induced the mitochondrial pathway of apoptosis. The proapoptotic properties of the sesquiterpene lactones were additionally demonstrated withannexin V staining. Compounds 1 and 2 increased the Bax/Bcl-2 expression and decreased the expressions of CDK1 and cyclin B2, as determined at the mRNA level by means of RT-PCR. These experimental results indicate that sesquiterpene lactones may be regarded as potential starting structures for the development of novel anticancer agents.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/farmacologia
Artemisia/química
Citostáticos/farmacologia
Onopordum/química
Sesquiterpenos/farmacologia
[Mh] Termos MeSH secundário: Antineoplásicos Fitogênicos/química
Apoptose
Caspase 3/metabolismo
Caspase 9/metabolismo
Ciclo Celular/efeitos dos fármacos
Citostáticos/química
Ensaios de Seleção de Medicamentos Antitumorais
Regulação Neoplásica da Expressão Gênica/efeitos dos fármacos
Células HL-60
Seres Humanos
Extratos Vegetais/química
Sesquiterpenos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Cytostatic Agents); 0 (Plant Extracts); 0 (Sesquiterpenes); EC 3.4.22.- (CASP3 protein, human); EC 3.4.22.- (CASP9 protein, human); EC 3.4.22.- (Caspase 3); EC 3.4.22.- (Caspase 9)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160223
[St] Status:MEDLINE


  4 / 22 MEDLINE  
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[PMID]:26383017
[Au] Autor:Lajter I; Pan SP; Nikles S; Ortmann S; Vasas A; Csupor-Löffler B; Forgó P; Hohmann J; Bauer R
[Ad] Endereço:Department of Pharmacognosy, University of Szeged, Szeged, Hungary.
[Ti] Título:Inhibition of COX-2 and NF-κB1 Gene Expression, NO Production, 5-LOX, and COX-1 and COX-2 Enzymes by Extracts and Constituents of Onopordum acanthium.
[So] Source:Planta Med;81(14):1270-6, 2015 Sep.
[Is] ISSN:1439-0221
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:The present study focused on the investigation of the inhibition of cyclooxygenase-2 and nuclear factor kappa B1 gene expression, nitric oxide production, leukotriene biosynthesis (5-lipoxygenase), and cyclooxygenase-1 and cyclooxygenase-2 enzymes of Onopordum acanthium, and the isolation and identification of its active compounds. From the chloroform soluble part of the MeOH extract prepared from aerial parts, lignans [pinoresinol (1), syringaresinol (2), and medioresinol (3)] and flavonoids [hispidulin (4), nepetin (5), apigenin (6), and luteolin (7)] were isolated by a combination of different chromatographic methods. The structures of the compounds were determined by means of mass spectrometry and 1D- and 2D-nuclear magnetic resonance spectroscopy, and by comparison of the spectral data with literature values. Extracts of different polarity and the isolated compounds obtained from the aerial parts, together with those previously isolated from the roots of the plant [4ß,15-dihydro-3-dehydrozaluzanin C (8), zaluzanin C (9), 4ß,15,11ß,13-tetrahydrozaluzanin C (10), nitidanin diisovalerianate (11), 24-methylenecholesterol (12), and 13-oxo-9Z,11E-octadecadienoic acid (13)], were evaluated for their inhibitory effects on cyclooxygenase-2 and nuclear factor kappa B1 gene expression, inducible nitric oxide synthase, 5-lipoxygenase, and cyclooxygenase-1 and cyclooxygenase-2 enzymes in in vitro assays. It was found that O. acanthium extracts exert strong inhibitory activities in vitro and some lignans, flavonoids, and sesquiterpenes may play a role in these activities. 4ß,15-Dihydro-3-dehydrozaluzanin C and zaluzanin C at 20 µM were the most active constituents tested against lipopolysaccharide/interferon-γ-induced nitric oxide production (100.4 ± 0.5 % and 99.4 ± 0.8 %) in the inhibition of cyclooxygenase-2 (98.6 ± 0.2 % and 97.0 ± 1.1 %) and nuclear factor kappa B1 gene expression (76.7 ± 7.3 % and 69.9 ± 3.4 %). Furthermore, it was shown that these inhibitory effects are not due to cytotoxicity of the compounds.
[Mh] Termos MeSH primário: Inibidores de Ciclo-Oxigenase/farmacologia
Subunidade p50 de NF-kappa B/genética
Óxido Nítrico/metabolismo
Onopordum/química
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Araquidonato 5-Lipoxigenase/genética
Araquidonato 5-Lipoxigenase/metabolismo
Linhagem Celular/efeitos dos fármacos
Ciclo-Oxigenase 1/genética
Ciclo-Oxigenase 1/metabolismo
Ciclo-Oxigenase 2/genética
Ciclo-Oxigenase 2/metabolismo
Inibidores de Ciclo-Oxigenase 2/farmacologia
Inibidores de Ciclo-Oxigenase/química
Avaliação Pré-Clínica de Medicamentos/métodos
Regulação da Expressão Gênica/efeitos dos fármacos
Seres Humanos
Inibidores de Lipoxigenase/química
Inibidores de Lipoxigenase/farmacologia
Estrutura Molecular
Subunidade p50 de NF-kappa B/antagonistas & inibidores
Óxido Nítrico Sintase Tipo II/genética
Óxido Nítrico Sintase Tipo II/metabolismo
Extratos Vegetais/química
Plantas Medicinais/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Cyclooxygenase 2 Inhibitors); 0 (Cyclooxygenase Inhibitors); 0 (Lipoxygenase Inhibitors); 0 (NF-kappa B p50 Subunit); 0 (NFKB1 protein, human); 0 (Plant Extracts); 31C4KY9ESH (Nitric Oxide); EC 1.13.11.34 (Arachidonate 5-Lipoxygenase); EC 1.14.13.39 (NOS2 protein, human); EC 1.14.13.39 (Nitric Oxide Synthase Type II); EC 1.14.99.1 (Cyclooxygenase 1); EC 1.14.99.1 (Cyclooxygenase 2); EC 1.14.99.1 (PTGS1 protein, human); EC 1.14.99.1 (PTGS2 protein, human); EC 1.3.11.34 (ALOX5 protein, human)
[Em] Mês de entrada:1606
[Cu] Atualização por classe:150919
[Lr] Data última revisão:
150919
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150919
[St] Status:MEDLINE
[do] DOI:10.1055/s-0035-1546242


  5 / 22 MEDLINE  
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[PMID]:26142501
[Au] Autor:Abusamra YA; Scuruchi M; Habibatni S; Maammeri Z; Benayache S; D'Ascola A; Avenoso A; Campo GM; Spina E
[Ad] Endereço:Deptt. of Clinical and Experimental Medicine, Policlinico Universitario, School of Medicine, University of Messina, Messina, Italy.
[Ti] Título:Evaluation of putative cytotoxic activity of crude extracts from Onopordum acanthium leaves and Spartium junceum flowers against the U-373 glioblastoma cell line.
[So] Source:Pak J Pharm Sci;28(4):1225-32, 2015 Jul.
[Is] ISSN:1011-601X
[Cp] País de publicação:Pakistan
[La] Idioma:eng
[Ab] Resumo:Crude hydromethanolic (80% methanol) extracts produced by maceration of Onopordum acanthium leaves and Spartium junceum flowers were tested for cytotoxic effects against glioblastoma U-373 tumour cells. Onopordum acanthium extract was found to be ~5 times more cytotoxic than Spartium junceum (IC50 values of 309 and 1602µg/ml, respectively). Similar to most chemotherapeutic agents killing through the intrinsic pathway, Onopordum killed the cells via apoptosis, which was confirmed by the activation of caspase-3. Spartium exerted its weak cytotoxic effect, presumably by a caspase-independent, non-apoptotic form of necrotic-like programmed cell death. Onopordum acanthium is considered a promising plant for the researchers investigating putative biological activities, particularly antitumour and immune-related activity.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/farmacologia
Neoplasias Encefálicas/tratamento farmacológico
Glioblastoma/tratamento farmacológico
Onopordum
Extratos Vegetais/farmacologia
Spartium
[Mh] Termos MeSH secundário: Neoplasias Encefálicas/patologia
Caspase 3/metabolismo
Linhagem Celular Tumoral
Flores
Glioblastoma/patologia
Seres Humanos
Folhas de Planta
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Plant Extracts); EC 3.4.22.- (Caspase 3)
[Em] Mês de entrada:1601
[Cu] Atualização por classe:150706
[Lr] Data última revisão:
150706
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150706
[St] Status:MEDLINE


  6 / 22 MEDLINE  
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[PMID]:25401776
[Au] Autor:Balao F; Casimiro-Soriguer R; García-Castaño JL; Terrab A; Talavera S
[Ad] Endereço:Departamento de Biología Vegetal y Ecología, Facultad de Biología, Universidad de Sevilla, Apdo. 1095, 41080, Sevilla, Spain; Department of Systematic and Evolutionary Botany, University of Vienna, Rennweg 14, 1030, Austria.
[Ti] Título:Big thistle eats the little thistle: does unidirectional introgressive hybridization endanger the conservation of Onopordum hinojense?
[So] Source:New Phytol;206(1):448-58, 2015 Apr.
[Is] ISSN:1469-8137
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Hybridization is known to have a creative role in plant evolution. However, it can also have negative effects on parental species. Onopordum is a large genus whose species frequently hybridize. In the Southwest Iberian Peninsula, the rare O. hinojense co-occurs with the widely distributed O. nervosum, and hybrids between these two taxa have been described as O. × onubense. In this study we determine the extinction risk in a hybrid zone, both for hybrids and parentals, using analyses of morphological and cytogenetic traits as well as genetic markers and demographic models. To investigate the introgression process we used amplified fragment length polymorphism (AFLP) markers, Bayesian analyses and genome scan methods. Morphology, genome size and molecular markers confirmed homoploid hybridization and also indicated unidirectional backcrossing of F1 hybrids with O. nervosum, which is likely to swamp O. hinojense, the parental with lower pollen size and a very low fruit set (8%). Genome scan methods revealed several loci significantly deviating from neutrality. Finally, our demographic modeling indicated that the higher fitness of O. nervosum threats the survival of O. hinojense by demographic swamping. Our study provides strong new evidence for a scenario of rapid extinction by unidirectional introgression and demographic swamping. The multifaceted approach used here sheds new light on the role of introgression in plant extinctions.
[Mh] Termos MeSH primário: Variação Genética
Hibridização Genética
Onopordum/genética
[Mh] Termos MeSH secundário: Análise do Polimorfismo de Comprimento de Fragmentos Amplificados
Teorema de Bayes
Conservação dos Recursos Naturais
Demografia
Marcadores Genéticos
Genética Populacional
Fenótipo
Polimorfismo Genético
Especificidade da Espécie
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Genetic Markers)
[Em] Mês de entrada:1602
[Cu] Atualização por classe:150225
[Lr] Data última revisão:
150225
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141118
[St] Status:MEDLINE
[do] DOI:10.1111/nph.13156


  7 / 22 MEDLINE  
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[PMID]:25230500
[Au] Autor:Daci A; Gold-Binder M; Garzon D; Patea A; Beretta G
[Ti] Título:Standardization of solvent extracts from Onopordum acanthium fruits by GC-MS, HPLC-UV/DAD, HPLC-TQMS and 1H-NMR and evaluation of their inhibitory effects on the expression of IL-8 and E-selectin in immortalized endothelial cells (HUVECtert).
[So] Source:Nat Prod Commun;9(7):945-8, 2014 Jul.
[Is] ISSN:1934-578X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In this work we have characterized and standardized the solvent extracts of the fruits of Onopordum acanthium, a plant widely distributed from Europe to Asia and used in different traditional medicines. Fruits were extracted with methanol (ME) and n-hexane (HE) and the extract compositions determined by GC-MS, HPLC-UV/DAD, HPLC-TQMS and 1H NMR spectroscopy. Anti-inflammatory activity (IL-8 and E-selectin, qPCR and ELISA) was investigated in HUVECtert cells stimulated with TNF-alpha and LPS. Arctiin and isochlorogenic acid were found in ME (87 +/- 2%, w/w, and 10.2 +/- 0.2%, w/w; 38.0 +/- 3.2 mg/gFRUITS and 3.5 +/- 0.4 mg/gFRUITS) and (ii) paraffins in the HE (195.6 +/- 5.6 mg/g). A dose dependent (from 15 to 40 microgME/mL corresponding to 20-75 microM arctiin) inhibition of E-selectin and of the induction of IL-8 was induced by LPS. The results of this study support the use of O. acanthium fruits in traditional medicine as an anti-inflammatory agent and for cancer prevention and treatment.
[Mh] Termos MeSH primário: Cromatografia Líquida de Alta Pressão/métodos
Frutas/química
Cromatografia Gasosa-Espectrometria de Massas/métodos
Espectroscopia de Ressonância Magnética/métodos
Onopordum/química
Extratos Vegetais/química
[Mh] Termos MeSH secundário: Antineoplásicos Fitogênicos/química
Antineoplásicos Fitogênicos/farmacologia
Linhagem Celular
Selectina E/genética
Selectina E/metabolismo
Regulação da Expressão Gênica/efeitos dos fármacos
Seres Humanos
Interleucina-8/genética
Interleucina-8/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (E-Selectin); 0 (IL8 protein, human); 0 (Interleukin-8); 0 (Plant Extracts)
[Em] Mês de entrada:1410
[Cu] Atualização por classe:140918
[Lr] Data última revisão:
140918
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140919
[St] Status:MEDLINE


  8 / 22 MEDLINE  
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[PMID]:25146768
[Au] Autor:Watanabe Y; Novaes P; Varela RM; Molinillo JM; Kato-Noguchi H; Macías FA
[Ad] Endereço:Department of Applied Biological Science, Faculty of Agriculture, Kagawa University, Miki, Kagawa 761-0795, Japan.
[Ti] Título:Phytotoxic potential of Onopordum acanthium L. (Asteraceae).
[So] Source:Chem Biodivers;11(8):1247-55, 2014 Aug.
[Is] ISSN:1612-1880
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Onopordum acanthium L. (Asteraceae) is a plant native to southern Europe and southwestern Asia, but it is invasive in disturbed areas and agricultural fields around the world, causing many agronomic problems by interfering with crops or preventing animals from grazing on pastures. Allelopathy could be one of the reasons that this plant has spread over different continents. The aim of the present study was to bioprospect O. acanthium leaf extracts through the isolation and purification of allelopathic secondary metabolites with phytotoxicity to explain their invasive behavior. Phytotoxic activity was tested using etiolated wheat coleoptiles. The most active extract was selected to perform a bioassay-guided isolation of two flavonoids, pectolarigenin (1) and scutellarein 4'-methyl ether (2), and two sesquiterpene lactones, elemanolide 11(13)-dehydromelitensin ß-hydroxyisobutyrate (3) and acanthiolide (4). All compounds were isolated for the first time from O. acanthium, and acanthiolide (4) is described for the first time. Compound 3 strongly inhibited the growth of wheat coleoptiles and 1 showed an intermediate effect. The results indicate that these compounds could contribute to the invasion of O. acanthium in ecological systems and agricultural fields.
[Mh] Termos MeSH primário: Espécies Introduzidas
Onopordum/química
Onopordum/metabolismo
Extratos Vegetais/toxicidade
Metabolismo Secundário
[Mh] Termos MeSH secundário: Alelopatia
Apigenina/isolamento & purificação
Apigenina/toxicidade
Cromonas/isolamento & purificação
Cromonas/farmacologia
Flavanonas/isolamento & purificação
Flavanonas/toxicidade
Espectroscopia de Ressonância Magnética
Estrutura Molecular
Extratos Vegetais/química
Extratos Vegetais/farmacologia
Folhas de Planta/química
Sesquiterpenos/isolamento & purificação
Sesquiterpenos/toxicidade
Triticum/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Chromones); 0 (Flavanones); 0 (Plant Extracts); 0 (Sesquiterpenes); 0 (pectolinarigenin); 0 (scutellarein tetramethyl ether); 7V515PI7F6 (Apigenin)
[Em] Mês de entrada:1505
[Cu] Atualização por classe:140822
[Lr] Data última revisão:
140822
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140823
[St] Status:MEDLINE
[do] DOI:10.1002/cbdv.201400070


  9 / 22 MEDLINE  
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[PMID]:25103576
[Au] Autor:Arfaoui MO; Renaud J; Ghazghazi H; Boukhchina S; Mayer P
[Ad] Endereço:a Laboratoire de Biochimie des lipides, Département de Biologie , Faculté des Sciences de Tunis , 2092 El Manar II , Tunisia.
[Ti] Título:Variation in oil content, fatty acid and phytosterols profile of Onopordum acanthium L. during seed development.
[So] Source:Nat Prod Res;28(24):2293-300, 2014.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:This study has determined oil, fatty acid (FA) and phytosterols content during the ripening of the Tunisian Onopordum acanthium L. seeds. In total, nine FAs and six phytosterols were identified. The main FAs were linoleic acid (0.18-8.06 mg/g of seed) followed by oleic acid (0.051-2.45 mg/g of seed), palmitic acid and stearic acid. Pentadecanoic acid was detected, for the first time, in unripe fruits and the two last stages of development were characterised by a relative abundance of erucic acid. Overall, ß-sitosterol (34.5-77.79% of total sterols) was the major 4-desmethylsterols during maturation. The first episodes of growth were characterised by the best amounts of stigmasterol and campesterol, while stigmastanol and Δ7 sitosterol had quoted the semi-ripe and fully ripe fruits; however, cholesterol was absent. These findings are useful in understanding a potential new source of important natural compounds (Phytosterols and USFA) found in this fruit and when harvest should be undertaken to optimise desired FA and phytosterols content.
[Mh] Termos MeSH primário: Ácidos Graxos/análise
Frutas/química
Onopordum/química
Fitosteróis/análise
Óleos Vegetais/análise
Sementes/química
[Mh] Termos MeSH secundário: Colesterol/análogos & derivados
Colesterol/análise
Ácido Linoleico/análise
Ácido Oleico/análise
Onopordum/crescimento & desenvolvimento
Sementes/crescimento & desenvolvimento
Sitosteroides/análise
Estigmasterol/análise
Tunísia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Fatty Acids); 0 (Phytosterols); 0 (Plant Oils); 0 (Sitosterols); 2UMI9U37CP (Oleic Acid); 5L5O665639 (campesterol); 97C5T2UQ7J (Cholesterol); 99WUK5D0Y8 (Stigmasterol); 9KJL21T0QJ (Linoleic Acid); C2NJ9WO6O7 (stigmastanol); CCW02D961F (pentadecanoic acid)
[Em] Mês de entrada:1502
[Cu] Atualização por classe:140929
[Lr] Data última revisão:
140929
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140809
[St] Status:MEDLINE
[do] DOI:10.1080/14786419.2014.940944


  10 / 22 MEDLINE  
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[PMID]:24926604
[Au] Autor:Durak H; Aysu T
[Ad] Endereço:Yuzuncu Yil University, Vocational School of Health Services, 65080 Van, Turkey.
[Ti] Título:Effects of catalysts and solvents on liquefaction of Onopordum heteracanthum for production of bio-oils.
[So] Source:Bioresour Technol;166:309-17, 2014 Aug.
[Is] ISSN:1873-2976
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Milled Onopordum heteracanthum stalks were converted to liquid products in organic solvents (methanol, ethanol and acetone) with (KOH and ZnCl2) and without catalyst in an autoclave at temperatures of 523, 543 and 563 K. Effects of liquefaction parameters such as catalyst and solvent were investigated. The percentage yields from supercritical methanol, ethanol and acetone conversions were 48.2, 50.4 and 66.2 at 563 K in the non-catalytic runs, respectively. In the catalytic run with ZnCl2, the highest conversion (70.2%) was obtained in acetone at the same temperature. The obtained liquid products at 563 K were analyzed and characterized by elemental, Fourier transform infrared spectroscopy, gas chromatography-mass spectrometry. 106 different compounds have been identified by GC-MS in the liquid products obtained in methanol at 563 K.
[Mh] Termos MeSH primário: Extração Líquido-Líquido/métodos
Onopordum/química
Óleos Vegetais/análise
Óleos Vegetais/isolamento & purificação
Caules de Planta/química
[Mh] Termos MeSH secundário: Acetona/farmacologia
Catálise
Cloretos
Cromatografia Gasosa-Espectrometria de Massas
Metanol
Solventes/farmacologia
Espectroscopia de Infravermelho com Transformada de Fourier
Temperatura Ambiente
Compostos de Zinco
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Chlorides); 0 (Plant Oils); 0 (Solvents); 0 (Zinc Compounds); 1364PS73AF (Acetone); 86Q357L16B (zinc chloride); Y4S76JWI15 (Methanol)
[Em] Mês de entrada:1508
[Cu] Atualização por classe:140701
[Lr] Data última revisão:
140701
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140614
[St] Status:MEDLINE



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