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[PMID]:28676058
[Au] Autor:Igwaran A; Iweriebor BC; Ofuzim Okoh S; Nwodo UU; Obi LC; Okoh AI
[Ad] Endereço:SAMRC Microbial Water Quality Monitoring Centre, University of Fort Hare, Alice, 5700, South Africa. aboi.igwaran@yahoo.com.
[Ti] Título:Chemical constituents, antibacterial and antioxidant properties of the essential oil flower of Tagetes minuta grown in Cala community Eastern Cape, South Africa.
[So] Source:BMC Complement Altern Med;17(1):351, 2017 Jul 05.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Tagetes minuta has a long record of human use for the treatment of stomach and intestinal diseases. Most drugs used for diseases treatment are less efficacious with side effects and this brought the search for new treatment regimens mainly from medicinal plants. METHOD: The essential oil (EO) was extracted by Clevenger's-type apparatus and its chemical composition, antioxidant and antibacterial properties were determined by GC-MS, spectrophotometric and broth dilution methods respectively. S. uberis, E. cloacae, S. aureus, M. smegmatis, L. ivanovii, Vibrio spp. and E. coli bacteria strains were used as test bacteria. RESULTS: GC-MS analysis revealed 98 compounds in the EO flower of T. minuta and ß-Ocimene (14. 40%) was the major chemical constituents. The EO exhibited highest inhibitory effect against DPPH radical, followed by its effect on ABTS, while LP radical showed the least sensitivity with IC values of 2.45 mg/mL, 2.76 mg/mL and 3.23 mg/mL respectively. The EO showed antibacterial activities against all test organisms with MIC value for S. aureus, M. smegatis and S. uberis at 0.125 mg/mL and for L. ivanovii, Vibrio spp., E. cloacae and E. coli at 0.06 mg/mL. The EO showed MBC against E. cloacae and E. coli at 0.06 mg/mL at 0.5 mg/mL for S. uberis and 0.125 mg/mL for Vibrio spp. CONCLUSION: Findings from this study suggest that the EO of T. minuta flower may be a useful candidate in the search for lead constituents for the synthesis of new potent antibacterial and antioxidant agent.
[Mh] Termos MeSH primário: Antibacterianos/química
Antioxidantes/química
Óleos Voláteis/química
Óleos Vegetais/química
Tagetes/química
[Mh] Termos MeSH secundário: Antibacterianos/isolamento & purificação
Antibacterianos/farmacologia
Antioxidantes/isolamento & purificação
Antioxidantes/farmacologia
Escherichia coli/efeitos dos fármacos
Escherichia coli/crescimento & desenvolvimento
Flores/química
Cromatografia Gasosa-Espectrometria de Massas
Testes de Sensibilidade Microbiana
Óleos Voláteis/isolamento & purificação
Óleos Voláteis/farmacologia
Óleos Vegetais/isolamento & purificação
Óleos Vegetais/farmacologia
Staphylococcus aureus/efeitos dos fármacos
Staphylococcus aureus/crescimento & desenvolvimento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Antioxidants); 0 (Oils, Volatile); 0 (Plant Oils)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170818
[Lr] Data última revisão:
170818
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170706
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-1861-6


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[PMID]:28299905
[Au] Autor:Ayub MA; Hussain AI; Hanif MA; Chatha SAS; Kamal GM; Shahid M; Janneh O
[Ad] Endereço:Department of Chemistry, University of Agriculture, Faisalabad, Pakistan.
[Ti] Título:Variation in Phenolic Profile, ß-Carotene and Flavonoid Contents, Biological Activities of Two Tagetes Species from Pakistani Flora.
[So] Source:Chem Biodivers;14(6), 2017 Jun.
[Is] ISSN:1612-1880
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:The objective of present study was to evaluate the variation in phenolic profile, ß-carotene, flavonoid contents, antioxidant and antimicrobial properties of Tagetes erecta and Tagetes patula (T. erecta and T. patula) through different in vitro assays. Antioxidant activity was determined through 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging and inhibition of linoleic acid peroxidation assays and antibacterial and antifungal activities studied using the disc diffusion and resazurin microtiter-plate assays against bacterial and fungal strains. Moreover, total phenolics (TP), total carotenoids (TC) and total flavonoids (TF) were also determined. Highest (TP 35.8 mg GAE/g) and TF (16.9 mg CE/g) contents were found in MeOH extract of T. patula. T. erecta extract showed higher TC contents (6.45 mg/g) than T. patula extract (6.32 mg/g). T. erecta exhibited the highest DPPH radical-scavenging activity (IC ) (5.73 µg/mL) and inhibition of linoleic acid peroxidation (80.1%). RP-HPLC revealed the presence of caffeic acid, sinapic acid and ferulic acid in Tagetes extracts, m-coumaric acid in T. erecta whereas chlorogenic acid in T. patula extract only. Both extracts possessed promising antimicrobial activity compared to the ciprofloxacin and flumequine (+ve controls) against Bacillus subtilis and Alternaria alternate. Both extract were rich source of polyphenols exhibiting excellent biological activities.
[Mh] Termos MeSH primário: Flavonoides/isolamento & purificação
Fenóis/isolamento & purificação
Tagetes/química
beta Caroteno/isolamento & purificação
[Mh] Termos MeSH secundário: Antibacterianos/isolamento & purificação
Antibacterianos/farmacologia
Antifúngicos/isolamento & purificação
Antifúngicos/farmacologia
Flavonoides/química
Flavonoides/farmacologia
Paquistão
Fenóis/química
Fenóis/farmacologia
Extratos Vegetais/química
Extratos Vegetais/farmacologia
Polifenóis/análise
Polifenóis/isolamento & purificação
beta Caroteno/química
beta Caroteno/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Antifungal Agents); 0 (Flavonoids); 0 (Phenols); 0 (Plant Extracts); 0 (Polyphenols); 01YAE03M7J (beta Carotene)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170822
[Lr] Data última revisão:
170822
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170317
[St] Status:MEDLINE
[do] DOI:10.1002/cbdv.201600463


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[PMID]:28286043
[Au] Autor:Piña-Vázquez DM; Mayoral-Peña Z; Gómez-Sánchez M; Salazar-Olivo LA; Arellano-Carbajal F
[Ad] Endereço:Universidad Autónoma de Querétaro, Facultad de Ciencias Naturales, Av. de las Ciencias S/N, Querétaro, Mexico.
[Ti] Título:Anthelmintic effect of Psidium guajava and Tagetes erecta on wild-type and Levamisole-resistant Caenorhabditis elegans strains.
[So] Source:J Ethnopharmacol;202:92-96, 2017 Apr 18.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:ETHNOPHARMACOLOGICAL RELEVANCE: Psidium guajava and Tagetes erecta have been used traditionally to treat gastrointestinal parasites, but their active metabolites and mechanisms of action remain largely unknown. AIM OF THE STUDY: To evaluate the anthelmintic potential of Psidium guajava and Tagetes erecta extracts on Levamisole-sensitive and Levamisole-resistant strains of the model nematode Caenorhabditis elegans. MATERIALS AND METHODS: Aqueous extracts of Psidium guajava (PGE) and Tagetes erecta (TEE) were assayed on locomotion and egg-laying behaviors of the wild-type (N2) and Levamisole-resistant (CB193) strains of Caenorhabditis elegans. RESULTS: Both extracts paralyzed wild-type and Levamisole-resistant nematodes in a dose-dependent manner. In wild-type worms, TEE 25mg/mL induced a 75% paralysis after 8h of treatment and PGE 25mg/mL induced a 100% paralysis after 4h of treatment. PGE exerted a similar paralyzing effect on N2 wild-type and CB193 Levamisole-resistant worms, while TEE only partially paralyzed CB193 worms. TEE 25mg/mL decreased N2 egg-laying by 65% with respect to the untreated control, while PGE did it by 40%. CONCLUSIONS: Psidium guajava leaves and Tagetes erecta flower-heads possess hydrosoluble compounds that block the motility of Caenorhabditis elegans by a mechanism different to that of the anthelmintic drug Levamisole. Effects are also observable on oviposition, which was diminished in the wild-type worms. The strong anthelmintic effects in crude extracts of these plants warrants future work to identify their active compounds and to elucidate their molecular mechanisms of action.
[Mh] Termos MeSH primário: Anti-Helmínticos/farmacologia
Caenorhabditis elegans/efeitos dos fármacos
Levamisol/farmacologia
Extratos Vegetais/farmacologia
Psidium/química
Tagetes/química
[Mh] Termos MeSH secundário: Animais
Relação Dose-Resposta a Droga
Resistência a Medicamentos
Flores/química
Locomoção/efeitos dos fármacos
Folhas de Planta/química
Reprodução/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anthelmintics); 0 (Plant Extracts); 2880D3468G (Levamisole)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170824
[Lr] Data última revisão:
170824
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170314
[St] Status:MEDLINE


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[PMID]:28218705
[Au] Autor:Park YJ; Park SY; Valan Arasu M; Al-Dhabi NA; Ahn HG; Kim JK; Park SU
[Ad] Endereço:Department of Crop Science, Chungnam National University, 99 Daehak-ro, Yuseong-gu, Daejeon 34134, Korea. yunji0825@hanmail.net.
[Ti] Título:Accumulation of Carotenoids and Metabolic Profiling in Different Cultivars of Tagetes Flowers.
[So] Source:Molecules;22(2), 2017 Feb 18.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Species of , which belong to the family Asteraceae show different characteristics including, bloom size, shape, and color; plant size; and leaf shape. In this study, we determined the differences in primary metabolites and carotenoid yields among six cultivars from two species, and . In total, we detected seven carotenoids in the examined cultivars: violaxanthin, lutein, zeaxanthin, α-carotene, ß-carotene, 9- -ß-carotene, and 13- -ß-carotene. In all the cultivars, lutein was the most abundant carotenoid. Furthermore, the contents of each carotenoid in flowers varied depending on the cultivar. Principal component analysis (PCA) facilitated metabolic discrimination between cultivars, with the exception of Inca Yellow and Discovery Orange. Moreover, PCA and orthogonal projection to latent structure-discriminant analysis (OPLS-DA) results provided a clear discrimination between and . Primary metabolites, including xylose, citric acid, valine, glycine, and galactose were the main components facilitating separation of the species. Positive relationships were apparent between carbon-rich metabolites, including those of the TCA cycle and sugar metabolism, and carotenoids.
[Mh] Termos MeSH primário: Carotenoides/química
Flores/química
Metabolômica
Tagetes/química
[Mh] Termos MeSH secundário: Vias Biossintéticas
Carotenoides/biossíntese
Cromatografia Gasosa
Flores/metabolismo
Cromatografia Gasosa-Espectrometria de Massas
Metabolômica/métodos
Tagetes/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
36-88-4 (Carotenoids)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170509
[Lr] Data última revisão:
170509
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170221
[St] Status:MEDLINE


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[PMID]:28202077
[Au] Autor:Kimutai A; Ngeiywa M; Mulaa M; Njagi PG; Ingonga J; Nyamwamu LB; Ombati C; Ngumbi P
[Ad] Endereço:Department of Biological Sciences, University of Kabianga, P.O. Box 2030-20200, Kericho, Kenya. kimutaialbert@yahoo.com.
[Ti] Título:Repellent effects of the essential oils of Cymbopogon citratus and Tagetes minuta on the sandfly, Phlebotomus duboscqi.
[So] Source:BMC Res Notes;10(1):98, 2017 Feb 15.
[Is] ISSN:1756-0500
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The sandfly, Phlebotomus duboscqi is a vector of zoonotic cutaneous leishmaniasis (ZCL) that is an important public health problem in Eastern Africa. Repellents have been used for protection of humans against vectors of ZCL and other vectors that transmit killer diseases including malaria, Rift Valley fever, dengue, and yellow fever. The repellent effects of different doses of the essential oils from the lemon grass, Cymbopogon citratus and Mexican marigold, Tagetes minuta were evaluated in a two-chamber bioassay against 3- to 7-day-old unfed females of P. duboscqi in the laboratory. The results were compared with those that were obtained when test animals were treated with an equivalent dose of diethyl-3-methylbenzamide, which is a repellent that is commonly used as a positive control. RESULTS: Overall, percentage repellency increased with increasing doses of the essential oils while biting rates decreased with increasing concentrations of the oils. Further, the oil of C. citratus was more potent than that of T. minuta with regard to protection time and biting deterrence. The effective doses at 50% (ED ) and at 90% (ED ) for the oil of C. citratus, were 0.04 and 0.79 mg/ml, respectively. Those of the oil of T. minuta were 0.10 and 12.58 mg/ml. In addition, the percentage repellency of 1 mg/ml of the essential oils of C. citratus and T. minuta against sandflies was 100% and 88.89%, respectively. A lower dose of 0.5 mg/ml of the oils, elicited 89.13% repellency for C. citratus and 52.22% for T. minuta. CONCLUSION: The laboratory tests showed that the essential oils of the two plants were highly repellent to adult sand flies, P. duboscqi. Thus, the two essential oils are candidate natural repellents that can be used against P. duboscqi due to their high efficacy at very low doses, hence, the envisaged safety in their use over chemical repellents. It remains to carry out clinical studies on human subjects with appropriate formulations of the oils prior to recommending their adoption for use against the sandflies.
[Mh] Termos MeSH primário: Cymbopogon/química
Repelentes de Insetos/farmacologia
Óleos Voláteis/farmacologia
Phlebotomus/fisiologia
Óleos Vegetais/farmacologia
Tagetes/química
[Mh] Termos MeSH secundário: Animais
Bioensaio/métodos
Cricetinae
DEET/farmacologia
Relação Dose-Resposta a Droga
Feminino
Cromatografia Gasosa-Espectrometria de Massas
Seres Humanos
Controle de Insetos/métodos
Insetos Vetores/efeitos dos fármacos
Insetos Vetores/fisiologia
Óleos Voláteis/isolamento & purificação
Óleos Vegetais/isolamento & purificação
Especificidade da Espécie
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Insect Repellents); 0 (Oils, Volatile); 0 (Plant Oils); 134-62-3 (DEET)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170227
[Lr] Data última revisão:
170227
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170217
[St] Status:MEDLINE
[do] DOI:10.1186/s13104-017-2396-0


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[PMID]:28152613
[Au] Autor:Omer EA; Hendawy SF; Ismail RF; Petretto GL; Rourke JP; Pintore G
[Ad] Endereço:a Department of Medicinal and Aromatic Plants Research , National Research Centre , Giza , Egypt.
[Ti] Título:Acclimatization study of Tagetes lucida L. in Egypt and the chemical characterization of its essential oils.
[So] Source:Nat Prod Res;31(13):1509-1517, 2017 Jul.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Seeds of Tagetes lucida were imported to Egypt from Canada and propagated under greenhouse conditions in peat moss media. Soil was sandy in texture and the irrigation system was dripping irrigation. The growth parameters were determined at five successive plant ages, fresh and dry weights of herb were determined at three successive plant ages. The yield of aerial parts after 175 days, was about 7.5 Mg/ha. The essential oil (EO) was extracted by hydro-distillation for three hours with a yield of about 0.5% (w/v). The EO of each sample was subjected to gas-chromatography/mass spectrometry analyses to study the chemical composition. The main component of the EO was identified as methyl chavicol which matched over 90% of the whole composition. Chlorophyll a and carotenes increased with increasing plant age in both sites and seasons. Flavonoids decreased with the development of plant age, while the opposite was true with coumarines content.
[Mh] Termos MeSH primário: Aclimatação
Óleos Voláteis/química
Tagetes/química
[Mh] Termos MeSH secundário: Anisóis/análise
Carotenoides/análise
Clorofila/análise
Destilação
Egito
Flavonoides/análise
Cromatografia Gasosa-Espectrometria de Massas
Óleos Vegetais/química
Tagetes/crescimento & desenvolvimento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anisoles); 0 (Flavonoids); 0 (Oils, Volatile); 0 (Plant Oils); 1406-65-1 (Chlorophyll); 36-88-4 (Carotenoids); 9NIW07V3ET (estragole); YF5Q9EJC8Y (chlorophyll a)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170922
[Lr] Data última revisão:
170922
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170204
[St] Status:MEDLINE
[do] DOI:10.1080/14786419.2017.1278594


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[PMID]:28081202
[Au] Autor:Ai Y; Zhang C; Sun Y; Wang W; He Y; Bao M
[Ad] Endereço:Key Laboratory of Horticultural Plant Biology, Ministry of Education, College of Horticulture and Forestry Sciences, Huazhong Agricultural University, Wuhan, Hubei, China.
[Ti] Título:Characterization and Functional Analysis of Five MADS-Box B Class Genes Related to Floral Organ Identification in Tagetes erecta.
[So] Source:PLoS One;12(1):e0169777, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:According to the floral organ development ABC model, B class genes specify petal and stamen identification. In order to study the function of B class genes in flower development of Tagetes erecta, five MADS-box B class genes were identified and their expression and putative functions were studied. Sequence comparisons and phylogenetic analyses indicated that there were one PI-like gene-TePI, two euAP3-like genes-TeAP3-1 and TeAP3-2, and two TM6-like genes-TeTM6-1 and TeTM6-2 in T. erecta. Strong expression levels of these genes were detected in stamens of the disk florets, but little or no expression was detected in bracts, receptacles or vegetative organs. Yeast hybrid experiments of the B class proteins showed that TePI protein could form a homodimer and heterodimers with all the other four B class proteins TeAP3-1, TeAP3-2, TeTM6-1 and TeTM6-2. No homodimer or interaction was observed between the euAP3 and TM6 clade members. Over-expression of five B class genes of T. erecta in Nicotiana rotundifolia showed that only the transgenic plants of 35S::TePI showed altered floral morphology compared with the non-transgenic line. This study could contribute to the understanding of the function of B class genes in flower development of T. erecta, and provide a theoretical basis for further research to change floral organ structures and create new materials for plant breeding.
[Mh] Termos MeSH primário: Proteínas de Domínio MADS/genética
Proteínas de Plantas/genética
Tagetes/genética
[Mh] Termos MeSH secundário: Sequência de Aminoácidos
Dimerização
Flores/genética
Flores/metabolismo
Regulação da Expressão Gênica de Plantas
Proteínas de Domínio MADS/classificação
Proteínas de Domínio MADS/metabolismo
Dados de Sequência Molecular
Fenótipo
Filogenia
Proteínas de Plantas/classificação
Proteínas de Plantas/metabolismo
Plantas Geneticamente Modificadas/genética
Plantas Geneticamente Modificadas/metabolismo
Isoformas de Proteínas/química
Isoformas de Proteínas/genética
Isoformas de Proteínas/metabolismo
RNA de Plantas/genética
RNA de Plantas/isolamento & purificação
RNA de Plantas/metabolismo
Alinhamento de Sequência
Tagetes/classificação
Tagetes/crescimento & desenvolvimento
Tagetes/metabolismo
Tabaco/genética
Tabaco/metabolismo
Técnicas do Sistema de Duplo-Híbrido
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (MADS Domain Proteins); 0 (Plant Proteins); 0 (Protein Isoforms); 0 (RNA, Plant)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170824
[Lr] Data última revisão:
170824
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170113
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0169777


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[PMID]:27981402
[Au] Autor:Yang N; Wang X; Zheng F; Chen Y
[Ad] Endereço:State Key Laboratory of Urban and Region Ecology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, China.
[Ti] Título:The response of marigold (Tagetes erecta Linn.) to ozone: impacts on plant growth and leaf physiology.
[So] Source:Ecotoxicology;26(1):151-164, 2017 Jan.
[Is] ISSN:1573-3017
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Progressively increasing ozone (O ) concentrations pose a potential threat to the value of marigold (Tagetes erecta Linn.), a plant widely used in urban landscaping. The response of marigold to elevated O has been reported earlier, but the mechanisms underlying the O effect have not been clearly elucidated. In the present study, we exposed marigold "Moonsong Deep Orange" plants to elevated O , including ambient non-filtered air (NF) plus 60 ppb (NF+60) and 120 ppb (NF+120) O , to assess visible injury and the possible physiological consequences of this pollutant. Yellow lesions appeared after 4 days under NF+120 treatment and 12 days under NF+60 treatment, with 85.6% and 36.8% of the leaves being injured at harvest time, respectively. Compared with NF, NF+60 inhibited leaf photosynthesis, stem-diameter growth, and biomass production significantly, while the parameters were decreased more by NF+120. Although the stomatal conductance decreased under elevated O exposure, the O flux into leaves increased by 28.0-104.8% under NF+60 treatment and 57.5-145.6% under NF+120 treatment. The total ascorbic acid (ASA) content increased due to elevated O exposure, while the reduced ASA content did not, resulting in a decreased ratio of reduced to total ASA. A lower level of jasmonic acid (JA) was observed under elevated O exposure. In conclusion, the impacts of elevated O on marigold plants may be ascribed to increased O flux into leaves and reduced protective capacity of leaves to convert oxidized to reduced ASA and synthesize endogenous JA.
[Mh] Termos MeSH primário: Poluentes Atmosféricos/toxicidade
Ozônio/toxicidade
Folhas de Planta/fisiologia
Tagetes/fisiologia
[Mh] Termos MeSH secundário: Biomassa
Fotossíntese/efeitos dos fármacos
Desenvolvimento Vegetal/efeitos dos fármacos
Folhas de Planta/efeitos dos fármacos
Tagetes/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Air Pollutants); 66H7ZZK23N (Ozone)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:171019
[Lr] Data última revisão:
171019
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161217
[St] Status:MEDLINE
[do] DOI:10.1007/s10646-016-1750-7


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[PMID]:27838836
[Au] Autor:Politi FA; Nascimento JD; da Silva AA; Moro IJ; Garcia ML; Guido RV; Pietro RC; Godinho AF; Furlan M
[Ad] Endereço:Department of Organic Chemistry, Institute of Chemistry, University Estadual Paulista-UNESP, Rua Prof. Francisco Degni 55, Quitandinha, Araraquara, SP, CEP 14800-060, Brazil. flaviopoliti@hotmail.com.
[Ti] Título:Insecticidal activity of an essential oil of Tagetes patula L. (Asteraceae) on common bed bug Cimex lectularius L. and molecular docking of major compounds at the catalytic site of ClAChE1.
[So] Source:Parasitol Res;116(1):415-424, 2017 Jan.
[Is] ISSN:1432-1955
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Emerging resistance to insecticides has influenced pharmaceutical research and the search for alternatives to control the common bed bug Cimex lectularius. In this sense, natural products can play a major role. Tagetes patula, popularly known as dwarf marigold, is a plant native to North America with biocide potential. The aim of this work was to evaluate the biological activity of T. patula essential oil (EO) against adult common bed bugs via exposure to dry residues by the Impregnated Paper Disk Test (IPDT) using cypermethrin as a positive control. We selected the enzyme acetylcholinesterase as a target for modeling studies, with the intent of investigating the molecular basis of any biological activity of the EO. Chemical analysis of the EO was performed using gas chromatography coupled to mass spectrometry (GC-MS). Additionally, oral and dermal acute toxicity tests were performed according to Organization for Economic Cooperation and Development (OECD) guidelines. The sulforhodamine B assay (SRB) was performed to verify the cytotoxicity of EO to HaCaT cells. The EO eliminated 100 % of the bed bugs at 100 mg mL with an LC value of 15.85 mg mL . GC-MS analysis identified α-terpinolene, limonene, piperitenone, and piperitone as major components of the mixture. Molecular modeling studies of these major compounds suggested that they are acetylcholinesterase inhibitors with good steric and electronic complementarity. The in vitro cytotoxicity evaluation revealed a LC = 37.06 µg mL and in vivo acute toxicity showed an LC >4000 mg kg , indicating that the EO presents low risk of toxic side effects in humans. The T. patula essential oil components provide a promising strategy for controlling bed bug populations with low mammalian toxicity. These findings pave the way for further in vivo studies aimed at developing a safe and effective insecticide.
[Mh] Termos MeSH primário: Percevejos-de-Cama/efeitos dos fármacos
Inseticidas/farmacologia
Óleos Voláteis/farmacologia
Óleos Vegetais/farmacologia
Tagetes/química
[Mh] Termos MeSH secundário: Animais
Domínio Catalítico
Cromatografia Gasosa-Espectrometria de Massas
Inseticidas/química
Simulação de Acoplamento Molecular
Óleos Voláteis/química
Óleos Vegetais/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Insecticides); 0 (Oils, Volatile); 0 (Plant Oils)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171007
[Lr] Data última revisão:
171007
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161114
[St] Status:MEDLINE


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[PMID]:27348403
[Au] Autor:Ibrahim SR; Mohamed GA
[Ad] Endereço:a Department of Pharmacognosy and Pharmaceutical Chemistry, College of Pharmacy , Taibah University , Al Madinah Al Munawwarah , Saudi Arabia.
[Ti] Título:Thiotagetin A, a new cytotoxic thiophene from Tagetes minuta.
[So] Source:Nat Prod Res;31(5):543-547, 2017 Mar.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Phytochemical investigation of the n-hexane fraction of the methanolic extract of Tagetes minuta L. (Asteraceae) aerial parts afforded a new thiophene derivative: thiotagetin A (3), together with ß-sitosterol (1) and stigmasterol (2). The structure of the new thiophene was identified by UV, IR, 1D ( H and C), 2D ( H- H COSY, HSQC and HMBC) NMR and HRESIMS spectral data. Compound 3 displayed cytotoxic activity against KB and MCF7 cancer cell lines with ED values of 2.03 and 3.88 µg/mL, respectively, compared to adriamycin (0.26 and 0.07 µg/mL, respectively).
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/isolamento & purificação
Tagetes/química
Tiofenos/isolamento & purificação
[Mh] Termos MeSH secundário: Linhagem Celular Tumoral
Seres Humanos
Extratos Vegetais/análise
Tiofenos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Plant Extracts); 0 (Thiophenes)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160628
[St] Status:MEDLINE
[do] DOI:10.1080/14786419.2016.1201672



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