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Pesquisa : B01.650.940.800.575.912.250.100.874.500 [Categoria DeCS]
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[PMID]:28854909
[Au] Autor:Guilbot A; Bangratz M; Ait Abdellah S; Lucas C
[Ad] Endereço:Pileje Laboratoire, 37 quai de Grenelle, 75015, 15, Paris cedex, France. a.guilbot@pileje.com.
[Ti] Título:A combination of coenzyme Q10, feverfew and magnesium for migraine prophylaxis: a prospective observational study.
[So] Source:BMC Complement Altern Med;17(1):433, 2017 Aug 30.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Feverfew (Tanacetum parthenium L.), magnesium and coenzyme Q10 are frequently used for migraine prophylaxis. Supplementation with a fixed combination of these three agents (Antemig®, PiLeJe) was investigated in an observational study. METHODS: Adult patients suffering from migraine according to the criteria of the International Headache Society were enrolled by general practitioners (≥2 migraine attacks during previous month; exclusion of chronic migraine and medication overuse) and after a one-month baseline phase, supplemented with one tablet of 100 mg feverfew, 100 mg coenzyme Q10 and 112.5 mg magnesium per day for 3 months. RESULTS: Supplementation significantly reduced the number of days with migraine headache during third month of supplementation compared to baseline phase (1.3 days ±1.5 versus 4.9 days ±2.6, p < 0.0001; n = 68 intention to treat; primary criterion). The decrease was progressive over the period of supplementation and significant from first month (1st month: -2.5 days ±3.1, p < 0.0001; 2nd month: -3 days ±2.8, p < 0.0001). The proportion of patients with a reduction of at least 50% in the number of days with migraine headache was 75% (51/68) after 3 months, with a progressive increase over the period of supplementation (63.2% [43/68] after 1 month and 70.6% [48/68] after 2 months). The proportion of patients with anxiety and depressive symptoms (Hospital Anxiety and Depression Scale) decreased between baseline phase and third month of supplementation from 61.9% (39/63 patients with information available) to 35% (21/60) for depression and from 52.4% (33/63) to 30% (18/60) for anxiety. An improvement of quality of life (Qualité de Vie et Migraine questionnaire) was also observed. The combination was well tolerated. CONCLUSIONS: Results suggest that the proprietary supplement containing feverfew, coenzyme Q10 and magnesium assessed could be beneficial and safe for the prevention of migraine in adult patients and merits further study. TRIAL REGISTRATION: ClinicalTrials.gov: NCT02901756 , retrospectively registered on August 24, 2016.
[Mh] Termos MeSH primário: Combinação de Medicamentos
Magnésio/administração & dosagem
Transtornos de Enxaqueca/prevenção & controle
Extratos Vegetais/administração & dosagem
Tanacetum parthenium/química
Ubiquinona/análogos & derivados
[Mh] Termos MeSH secundário: Adolescente
Adulto
Idoso
Suplementos Nutricionais/análise
Feminino
Seres Humanos
Masculino
Meia-Idade
Estudos Prospectivos
Qualidade de Vida
Ubiquinona/administração & dosagem
Adulto Jovem
[Pt] Tipo de publicação:JOURNAL ARTICLE; OBSERVATIONAL STUDY
[Nm] Nome de substância:
0 (Drug Combinations); 0 (Plant Extracts); 1339-63-5 (Ubiquinone); EJ27X76M46 (coenzyme Q10); I38ZP9992A (Magnesium)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170913
[Lr] Data última revisão:
170913
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170901
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-1933-7


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[PMID]:28357789
[Au] Autor:Hojati M; Modarres-Sanavy SAM; Enferadi ST; Majdi M; Ghanati F; Farzadfar S; Pazoki A
[Ad] Endereço:Department of Agronomy, Faculty of Agriculture, Tarbiat Modares University, Jallal-Al-Ahmad Highway, Nasr Bridge, Tehran, Iran.
[Ti] Título:Cadmium and copper induced changes in growth, oxidative metabolism and terpenoids of Tanacetum parthenium.
[So] Source:Environ Sci Pollut Res Int;24(13):12261-12272, 2017 May.
[Is] ISSN:1614-7499
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Morphological and biochemical responses of feverfew plants exposed to low (5 µM) and high (35 and 70 µM) levels of Cd or Cu were investigated. Increasing metal supply notably reduced the plant biomass. Elevated Cd and Cu levels also resulted in an increase in the leaf proline content. Besides, decrease in ascorbic acid (AsA) and glutathione (GSH) contents was similar in the leaves of Cd- and Cu-treated plants, indicating altered biosynthesis of AsA and GSH under metal excess. High metal doses stimulated increase in antioxidative enzyme activities that could be related to elevated hydrogen peroxide (H O ) content and subsequent lipid peroxidation. Cd was typically more accumulated in shoots and roots than Cu, leading to higher translocation factor at high Cd doses. In terms of essential oil content, it seems that Cd had an inhibitory effect during the experiment, whereas Cu was found to stimulate it only at 5 µM. Furthermore, high Cd supply enhanced the relative proportion of monoterpene hydrocarbons, while Cu increased the proportion of sesquiterpenes, especially at 5 µM. This result provides the first evidence of the response of feverfew plants to Cd or Cu by associating stress-related responses with changes in terpenoids.
[Mh] Termos MeSH primário: Cádmio/metabolismo
Cobre/metabolismo
[Mh] Termos MeSH secundário: Antioxidantes/metabolismo
Peróxido de Hidrogênio/metabolismo
Estresse Oxidativo/efeitos dos fármacos
Raízes de Plantas/metabolismo
Tanacetum parthenium
Terpenos/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Terpenes); 00BH33GNGH (Cadmium); 789U1901C5 (Copper); BBX060AN9V (Hydrogen Peroxide)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171104
[Lr] Data última revisão:
171104
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170331
[St] Status:MEDLINE
[do] DOI:10.1007/s11356-017-8846-3


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[PMID]:28213105
[Au] Autor:Cárdenas J; Reyes-Pérez V; Hernández-Navarro MD; Dorantes-Barrón AM; Almazán S; Estrada-Reyes R
[Ad] Endereço:Instituto de Química, Universidad Nacional Autónoma de México (UNAM), Coyoacán, 04510 Ciudad de México (CDMX), México.
[Ti] Título:Anxiolytic- and antidepressant-like effects of an aqueous extract of Tanacetum parthenium L. Schultz-Bip (Asteraceae) in mice.
[So] Source:J Ethnopharmacol;200:22-30, 2017 Mar 22.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:AIM: Tanacetum parthenium L. Schultz-Bip (Asteraceae) is widely used worldwide in traditional medicine for the treatment of convulsions and culture-bound syndromes such as susto (fear). The aim of this work was to evaluate the anxiolytic- and antidepressant-like effects of an aqueous extract of T. parthenium in behavioral paradigms in mice. The effects of T. parthenium were compared with those produced by anxiolytic and antidepressant drugs. We carried out the chemical characterization of the main constituents of T. parthenium. The involvement with the GABAergic and serotoninergic neurotransmitter systems were explored be means of synergic and antagonist experiments. MATERIALS AND METHODS: The anxiolytic-like effect was evaluated using the Burying Behavior Test (BBT) and the Elevated Plus-Maze Test (PMT). The antidepressant-like effect was evaluated in the Forced Swimming Test (FST), and ambulatory activity was assessed in the Open Field Test (OFT). Employing the behavioral tests, synergism and antagonism experiments with Alprazolam, Muscimol, and Picrotoxin were carried out in the PMT. In a series of independent experiments, concomitant administration of T. parthenium and Alprazolam, Fluoxetine, or p-chlorophenylalanine were conducted in the FST. For chemical characterization, High-Performance Liquid Chromatography-Electro Spray Ionization-Mass Spectrometry (HPLC-ESI-MS) analysis was performed. RESULTS: T. parthenium exerts clear anxiolytic- and antidepressant-like effects in mice, without affecting the ambulatory activity of the experimental subjects. CONCLUSIONS: Anxiolytic- and antidepressant-like T. parthenium effects result, at least part from the involvement of the GABAergic system. Our results support the use of Tanacetum parthenium in traditional medicine and suggest its therapeutic potential in the comorbid anxiety and depression.
[Mh] Termos MeSH primário: Ansiolíticos/farmacologia
Antidepressivos/farmacologia
Atividade Motora/efeitos dos fármacos
Extratos Vegetais/farmacologia
Tanacetum parthenium
[Mh] Termos MeSH secundário: Animais
Ansiolíticos/isolamento & purificação
Antidepressivos/isolamento & purificação
Asteraceae
Relação Dose-Resposta a Droga
Masculino
Aprendizagem em Labirinto/efeitos dos fármacos
Aprendizagem em Labirinto/fisiologia
Camundongos
Atividade Motora/fisiologia
Componentes Aéreos da Planta
Extratos Vegetais/isolamento & purificação
Natação/fisiologia
Natação/psicologia
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Anxiety Agents); 0 (Antidepressive Agents); 0 (Plant Extracts)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170719
[Lr] Data última revisão:
170719
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170219
[St] Status:MEDLINE


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[PMID]:28092849
[Au] Autor:Farzadfar S; Zarinkamar F; Hojati M
[Ad] Endereço:Department of Plant Biology, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran.
[Ti] Título:Magnesium and manganese affect photosynthesis, essential oil composition and phenolic compounds of Tanacetum parthenium.
[So] Source:Plant Physiol Biochem;112:207-217, 2017 Mar.
[Is] ISSN:1873-2690
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:The accumulation of plant defense metabolites is closely associated with the concentration of nutrient elements, yet data related to the interactive effects of two nutrients on the deployment of phenolics and terpenoids are scare. In the present study, the interaction between magnesium (Mg) and manganese (Mn) on nutrient uptake, photosynthesis, oxidative status and the accumulation of phenolics and terpenoids in the leaves of feverfew plants grown at different concentrations of Mg and Mn was investigated. Nutrient uptake and photosynthesis were associated with the amount of applied Mg but could be modified by the concentration of Mn. Phenolic biosynthetic enzymes and individual phenolics were not only induced by Mg, but their levels were also dependent on the Mn supply. Additionally, the proportion of monoterpenes was enhanced by a deficiency of Mg rather than an excess of Mn. Deprivation of Mg also decreased the proportion of sesquiterpenes in the essential oil. Therefore, it appears that a high Mg and a low Mn supply lead to a marked shift from monoterpene to sesquiterpene production. Phenolic compounds also differentially accumulated under varying Mg and Mn concentrations. These results suggest a profound effect of the combined supply of Mg and Mn on the biosynthesis of terpenes and phenolics.
[Mh] Termos MeSH primário: Magnésio/farmacologia
Manganês/farmacologia
Óleos Voláteis/metabolismo
Fenóis/metabolismo
Fotossíntese/efeitos dos fármacos
Tanacetum parthenium/fisiologia
[Mh] Termos MeSH secundário: Vias Biossintéticas/efeitos dos fármacos
Metaboloma/efeitos dos fármacos
Oxirredução/efeitos dos fármacos
Complexo de Proteína do Fotossistema II/metabolismo
Estômatos de Plantas/efeitos dos fármacos
Estômatos de Plantas/fisiologia
Transpiração Vegetal/efeitos dos fármacos
Análise de Componente Principal
Tanacetum parthenium/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Oils, Volatile); 0 (Phenols); 0 (Photosystem II Protein Complex); 42Z2K6ZL8P (Manganese); I38ZP9992A (Magnesium)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170501
[Lr] Data última revisão:
170501
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170117
[St] Status:MEDLINE


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[PMID]:27997959
[Au] Autor:de Carvalho LSA; Fontes LBA; Gazolla MC; Dias DDS; Juliano MA; Macedo GC; Otávio do Amaral Corrêa J; Da Silva Filho AA
[Ad] Endereço:Departamento de Ciências Farmacêuticas, Faculdade de Farmácia, Universidade Federal de Juiz de Fora, Juiz de Fora, Brasil.
[Ti] Título:Parthenolide Modulates Immune Response in Cells from C57BL/6 Mice Induced with Experimental Autoimmune Encephalomyelitis.
[So] Source:Planta Med;83(8):693-700, 2017 May.
[Is] ISSN:1439-0221
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Multiple sclerosis is a chronic inflammatory and autoimmune disease of the central nervous system that affects more than 2.5 million people worldwide. Experimental autoimmune encephalomyelitis is a murine autoimmune disease used to study multiple sclerosis. Parthenolide, a natural sesquiterpene lactone found in L., is known for its strong anti-inflammatory activity. Herein, we have investigated the immunomodulatory effects of parthenolide on cytokine production and nitric oxide in cultured cells from myelin oligodendrocyte glycoprotein 35-55 amino acid peptide mice. Experimental autoimmune encephalomyelitis was induced in C57BL/6 mice with myelin oligodendrocyte glycoprotein 35-55 amino acid peptide, and parthenolide was isolated from . Splenocytes and peritoneal cells were obtained from experimental autoimmune encephalomyelitis-induced mice and incubated with parthenolide (1, 5, and 20 µM). After treatment with parthenolide, supernatants were collected, and nitric oxide and cytokines were measured. The results suggested that parthenolide may regulate the activity of Th17 and Th1 cells, mainly by decreasing IL-17, TNF- , and interferon gamma production. This modulation may be related to the lower levels of IL-12p40 and IL-6 after treatment with parthenolide. It was shown, for the first time, that parthenolide presents immunomodulatory effects on inflammatory mediators produced by cells from experimental autoimmune encephalomyelitis-induced mice.
[Mh] Termos MeSH primário: Anti-Inflamatórios não Esteroides/uso terapêutico
Encefalomielite Autoimune Experimental/tratamento farmacológico
Imunidade Celular/efeitos dos fármacos
Esclerose Múltipla/tratamento farmacológico
Extratos Vegetais/uso terapêutico
Sesquiterpenos/uso terapêutico
Tanacetum parthenium/química
[Mh] Termos MeSH secundário: Animais
Citocinas/metabolismo
Encefalomielite Autoimune Experimental/imunologia
Fatores Imunológicos/uso terapêutico
Camundongos Endogâmicos C57BL
Esclerose Múltipla/imunologia
Sesquiterpenos/isolamento & purificação
Baço/citologia
Linfócitos T Auxiliares-Indutores/efeitos dos fármacos
Linfócitos T Auxiliares-Indutores/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents, Non-Steroidal); 0 (Cytokines); 0 (Immunologic Factors); 0 (Plant Extracts); 0 (Sesquiterpenes); 2RDB26I5ZB (parthenolide)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170706
[Lr] Data última revisão:
170706
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161221
[St] Status:MEDLINE
[do] DOI:10.1055/s-0042-122783


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[PMID]:27717727
[Au] Autor:Arikan-Ayyildiz Z; Karaman M; Özbal S; Bagriyanik A; Yilmaz O; Karaman Ö; Uzuner N
[Ad] Endereço:Department of Pediatric Allergy, Dokuz Eylul University, Faculty of Medicine, Izmir, Turkey. Electronic address: zarikanayyildiz@gmail.com.
[Ti] Título:Efficacy of parthenolide on lung histopathology in a murine model of asthma.
[So] Source:Allergol Immunopathol (Madr);45(1):63-68, 2017 Jan - Feb.
[Is] ISSN:1578-1267
[Cp] País de publicação:Spain
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Parthenolide is the active constituent of the plant 'Tanacetum parthenium' (Feverfew) which has been used for centuries as a folk remedy for inflammatory conditions. AIM OF THE STUDY: In this study we aimed to investigate the effects of parthenolide in a murine model of chronic asthma. MATERIALS AND METHODS: Thirty-five BALB/c mice were divided into five groups; I (control), II (placebo), III (dexamethasone), IV (parthenolide) and V (dexamethasone and parthenolide combination). Lung histology was evaluated after treatment with the study drugs. Levels of interleukin (IL)-4 and IL-5 were determined by ELISA. RESULTS: Histologic parameters except the number of mast and goblet cells improved in the parthenolide group when compared with placebo. All parameters except basal membrane thickness and number of mast cells were improved significantly better in the group receiving dexamethasone when compared with the parthenolide group. Improvement of most of the histologic parameters was similar in Groups III and V. Interleukin-4 levels were significantly reduced in the parthenolide group when compared to the placebo group. CONCLUSION: We demonstrated that parthenolide administration alleviated some of the pathological changes in asthma. But parthenolide alone is not efficient as dexamethasone therapy and the parthenolide and dexamethasone combination also did not add any beneficial effect to the dexamethasone treatment.
[Mh] Termos MeSH primário: Asma/tratamento farmacológico
Interleucina-4/metabolismo
Pulmão/efeitos dos fármacos
Sesquiterpenos/uso terapêutico
Tanacetum parthenium
[Mh] Termos MeSH secundário: Animais
Dexametasona/uso terapêutico
Modelos Animais de Doenças
Regulação para Baixo
Feminino
Seres Humanos
Interleucina-4/genética
Interleucina-5/metabolismo
Pulmão/patologia
Medicina Tradicional
Camundongos
Camundongos Endogâmicos BALB C
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Interleukin-5); 0 (Sesquiterpenes); 207137-56-2 (Interleukin-4); 2RDB26I5ZB (parthenolide); 7S5I7G3JQL (Dexamethasone)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170130
[Lr] Data última revisão:
170130
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161009
[St] Status:MEDLINE


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[PMID]:27450490
[Au] Autor:Farzadfar S; Zarinkamar F; Behmanesh M; Hojati M
[Ad] Endereço:Department of Plant Biology, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran.
[Ti] Título:Magnesium and manganese interactively modulate parthenolide accumulation and the antioxidant defense system in the leaves of Tanacetum parthenium.
[So] Source:J Plant Physiol;202:10-20, 2016 Sep 01.
[Is] ISSN:1618-1328
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:A balanced nutrient supply is a critical factor affecting accumulation of terpenoids in plants, yet data related to the interactive effects of two essential nutrients for the biosynthesis of sesquiterpenes are scarce. Here, the interactional effects between magnesium (Mg) and manganese (Mn) on plant growth, oxidative status, parthenolide accumulation and expression of key genes involved in parthenolide biosynthesis including 1-deoxy-d-xylulose-5-phosphate reductoisomerase (DXR), hydroxy-2-methyl-2-(E)-butenyl-4-diphosphate reductase (HDR), 3-hydroxy-3-methylglutarylcoenzyme A reductase (HMGR), germacrene A synthase (GAS), germacrene A oxidase (GAO), costunolide synthase (COS) and parthenolide synthase (PTS) in the leaves of feverfew plants grown at different Mn and Mn levels were assessed. Plant growth and leaf pigment concentrations were associated with the amount of applied Mg but could be modified by the Mn level. Deprivation and the addition of both Mg and Mn induce oxidative stress. Mg supply also alleviated the adverse effects of Mn excess on plant growth and oxidative status. In addition, parthenolide biosynthesis decreased under deprivation of Mg or Mn, but the addition of Mn up to 50µM under 2mM Mg supply considerably increased its accumulation. The parthenolide accumulation trend might reflect the up-regulation of terpenoid-related genes and enzyme activities as well as the oxidative status of feverfew leaves. Our data suggest a profound effect of the combined supply of Mg and Mn on parthenolide biosynthesis through the activation of terpene synthases, which concomitantly modulate by oxidative status.
[Mh] Termos MeSH primário: Magnésio/farmacologia
Manganês/farmacologia
Folhas de Planta/metabolismo
Sesquiterpenos/metabolismo
Tanacetum parthenium/metabolismo
[Mh] Termos MeSH secundário: Antioxidantes/metabolismo
Vias Biossintéticas/efeitos dos fármacos
Regulação da Expressão Gênica de Plantas/efeitos dos fármacos
Malondialdeído/metabolismo
Redes e Vias Metabólicas/efeitos dos fármacos
Pigmentos Biológicos/metabolismo
Folhas de Planta/efeitos dos fármacos
Raízes de Plantas/efeitos dos fármacos
Raízes de Plantas/metabolismo
Brotos de Planta/efeitos dos fármacos
Brotos de Planta/metabolismo
Prolina/metabolismo
Tanacetum parthenium/efeitos dos fármacos
Tanacetum parthenium/genética
Tanacetum parthenium/crescimento & desenvolvimento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Pigments, Biological); 0 (Sesquiterpenes); 2RDB26I5ZB (parthenolide); 42Z2K6ZL8P (Manganese); 4Y8F71G49Q (Malondialdehyde); 9DLQ4CIU6V (Proline); I38ZP9992A (Magnesium)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170410
[Lr] Data última revisão:
170410
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160725
[St] Status:MEDLINE


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[PMID]:27324458
[Au] Autor:Végh K; Riethmüller E; Tóth A; Alberti Á; Béni S; Balla J; Kéry Á
[Ad] Endereço:Department of Pharmacognosy, Semmelweis University, H-1085 Budapest, Ülloi str. 26., Hungary.
[Ti] Título:Convergence chromatographic determination of camphor in the essential oil of Tanacetum parthenium L.
[So] Source:Biomed Chromatogr;30(12):2031-2037, 2016 Dec.
[Is] ISSN:1099-0801
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Feverfew (Tanacetum parthenium L., Asteraceae) is a perennial medicinal plant which has been used to alleviate the symptoms of migraine, headache and rheumatoid arthritis and possesses numerous pharmacological activities. An ultra-high-performance supercritical fluid chromatographic method (UHPSFC) was developed and validated in accordance with the International Conference on Harmonization guidelines in order to determine the camphor content of the volatile oil, which was accurate, precise, robust and selective. The method was validated for specificity, accuracy (100.2%), repeatability and intermediate precision, linearity (r > 0.999), limit of detection (2.055 µg/mL), limit of quantification (6.228 µg/mL) and robustness. The common range of accuracy and linearity was between 0.125 and 1.000 mg/mL. Steam distillation was carried out in order to study the essential oil yield of three different T. parthenium L. samples originating from Hungarian medicinal herb collections. The camphor content of the essential oils from the aerial parts of feverfew samples from different origin was compared. Although the composition of the essential oil is well reported, a validated quantitative UHPSFC method for the determination of the constituents is presented herein for the first time.
[Mh] Termos MeSH primário: Cânfora/análise
Cromatografia Líquida/métodos
Óleos Voláteis/química
Tanacetum parthenium/química
[Mh] Termos MeSH secundário: Limite de Detecção
Reprodutibilidade dos Testes
[Pt] Tipo de publicação:JOURNAL ARTICLE; VALIDATION STUDIES
[Nm] Nome de substância:
0 (Oils, Volatile); 76-22-2 (Camphor)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170208
[Lr] Data última revisão:
170208
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160622
[St] Status:MEDLINE
[do] DOI:10.1002/bmc.3781


  9 / 173 MEDLINE  
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[PMID]:27002142
[Au] Autor:Duan D; Zhang J; Yao J; Liu Y; Fang J
[Ad] Endereço:From the State Key Laboratory of Applied Organic Chemistry and College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000 and the Shannxi Key Laboratory of Phytochemistry, Baoji University of Arts and Sciences, Baoji 721013, China.
[Ti] Título:Targeting Thioredoxin Reductase by Parthenolide Contributes to Inducing Apoptosis of HeLa Cells.
[So] Source:J Biol Chem;291(19):10021-31, 2016 May 06.
[Is] ISSN:1083-351X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Parthenolide (PTL), a major active sesquiterpene lactone from the herbal plant Tanacetum parthenium, has been applied in traditional Chinese medicine for centuries. Although PTL demonstrates potent anticancer efficacy in numerous types of malignant cells, the cellular targets of PTL have not been well defined. We reported here that PTL interacts with both cytosolic thioredoxin reductase (TrxR1) and mitochondrial thioredoxin reductase (TrxR2), two ubiquitous selenocysteine-containing antioxidant enzymes, to elicit reactive oxygen species-mediated apoptosis in HeLa cells. PTL selectively targets the selenocysteine residue in TrxR1 to inhibit the enzyme function, and further shifts the enzyme to an NADPH oxidase to generate superoxide anions, leading to reactive oxygen species accumulation and oxidized thioredoxin. Under the conditions of inhibition of TrxRs in cells, PTL does not cause significant alteration of cellular thiol homeostasis, supporting selective target of TrxRs by PTL. Importantly, overexpression of functional TrxR1 or Trx1 confers protection, whereas knockdown of the enzymes sensitizes cells to PTL treatment. Targeting TrxRs by PTL thus discloses an unprecedented mechanism underlying the biological activity of PTL, and provides deep insights to understand the action of PTL in treatment of cancer.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/farmacologia
Apoptose/efeitos dos fármacos
Proteínas de Neoplasias/antagonistas & inibidores
Neoplasias/tratamento farmacológico
Sesquiterpenos/farmacologia
Tiorredoxina Redutase 1/antagonistas & inibidores
[Mh] Termos MeSH secundário: Antineoplásicos Fitogênicos/química
Células HeLa
Seres Humanos
NADPH Oxidases/metabolismo
Neoplasias/enzimologia
Sesquiterpenos/química
Superóxidos/metabolismo
Tanacetum parthenium/química
Tiorredoxina Redutase 1/metabolismo
Tiorredoxina Redutase 2/antagonistas & inibidores
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Neoplasm Proteins); 0 (Sesquiterpenes); 11062-77-4 (Superoxides); 2RDB26I5ZB (parthenolide); EC 1.6.3.- (NADPH Oxidases); EC 1.8.1.9 (TXNRD1 protein, human); EC 1.8.1.9 (TXNRD2 protein, human); EC 1.8.1.9 (Thioredoxin Reductase 1); EC 1.8.1.9 (Thioredoxin Reductase 2)
[Em] Mês de entrada:1611
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160323
[St] Status:MEDLINE
[do] DOI:10.1074/jbc.M115.700591


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[PMID]:26183953
[Au] Autor:Majdi M; Abdollahi MR; Maroufi A
[Ad] Endereço:Department of Agricultural Biotechnology, Faculty of Agriculture, University of Kurdistan, Sanandaj, Iran. m.majdi@uok.ac.ir.
[Ti] Título:Parthenolide accumulation and expression of genes related to parthenolide biosynthesis affected by exogenous application of methyl jasmonate and salicylic acid in Tanacetum parthenium.
[So] Source:Plant Cell Rep;34(11):1909-18, 2015 Nov.
[Is] ISSN:1432-203X
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:KEY MESSAGE: Up-regulation of germacrene A synthase and down-regulation of parthenolide hydroxylase genes play key role in parthenolide accumulation of feverfew plants treated with methyl jasmonate and salicylic acid. Parthenolide is an important sesquiterpene lactone due to its anti-migraine and anti-cancer properties. Parthenolide amount was quantified by high-performance liquid chromatography after foliar application of methyl jasmonate (100 µM) or salicylic acid (1.0 mM) on feverfew leaves in time course experiment (3-96 h). Results indicate that exogenous application of methyl jasmonate or salicylic acid activated parthenolide biosynthesis. Parthenolide content reached its highest amount at 24 h after methyl jasmonate or salicylic acid treatments, which were 3.1- and 1.96-fold higher than control plants, respectively. Parthenolide transiently increased due to methyl jasmonate or salicylic acid treatments until 24 h, but did not show significant difference compared with control plants at 48 and 96 h time points in both treatments. Also, the transcript levels of early pathway (upstream) genes of terpene biosynthesis including 3-hydroxy-3-methylglutaryl-coenzyme A reductase, 1-deoxy-D-xylulose-5-phosphate reductoisomerase and hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase and the biosynthetic genes of parthenolide including germacrene A synthase, germacrene A oxidase, costunolide synthase and parthenolide synthase were increased by methyl jasmonate and salicylic acid treatments, but with different intensity. The transcriptional levels of these genes were higher in methyl jasmonate-treated plants than salicylic acid-treated plants. Parthenolide content measurements along with expression pattern analysis of the aforementioned genes and parthenolide hydroxylase as side branch gene of parthenolide suggest that the expression patterns of early pathway genes were not directly consistent with parthenolide accumulation pattern; hence, parthenolide accumulation is probably further modulated by the expression of its biosynthetic genes, especially germacrene A synthase and also its side branch gene, parthenolide hydroxylase.
[Mh] Termos MeSH primário: Acetatos/farmacologia
Ciclopentanos/farmacologia
Regulação da Expressão Gênica de Plantas/efeitos dos fármacos
Oxilipinas/farmacologia
Ácido Salicílico/farmacologia
Sesquiterpenos/metabolismo
[Mh] Termos MeSH secundário: Reguladores de Crescimento de Planta/farmacologia
Tanacetum parthenium/efeitos dos fármacos
Tanacetum parthenium/genética
Tanacetum parthenium/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Acetates); 0 (Cyclopentanes); 0 (Oxylipins); 0 (Plant Growth Regulators); 0 (Sesquiterpenes); 2RDB26I5ZB (parthenolide); 900N171A0F (methyl jasmonate); O414PZ4LPZ (Salicylic Acid)
[Em] Mês de entrada:1608
[Cu] Atualização por classe:171004
[Lr] Data última revisão:
171004
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150718
[St] Status:MEDLINE
[do] DOI:10.1007/s00299-015-1837-2



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