Base de dados : MEDLINE Pesquisa : B01.650.940.800.575.912.250.100.994 [Categoria DeCS] Referências encontradas : 150 [refinar] Mostrando: 1 .. 10   no formato [Detalhado]

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[PMID]: 27772796 [Au] Autor: Qu J; Deng S; Li L; Liu Y; Li Y; Ma S; Chen X; Yu S [Ad] Endereço: State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, PR China. [Ti] Título: Cytotoxic dimeric xanthanolides from fruits of Xanthium chinense. [So] Source: Phytochemistry;132:115-122, 2016 Dec. [Is] ISSN: 1873-3700 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: Nine dimeric xanthanolides, pungiolides F-N, and five known analogues, pungiolides A-E, were isolated from fruits of Xanthium chinense. Their structures were elucidated through spectroscopic and electronic circular dichroism (ECD) analyses. Pungiolide F is a xanthanolide dimer with an acyclic linkage. Five of the dimers, pungiolides H, L, A, C and E, exhibited moderate cytotoxicities with IC values in the range of 0.90-6.84 µM using taxol as the positive control, which had, by comparison, IC values in the range of 0.00118-0.0675 µM. These findings enrich the structural diversity of dimeric sesquiterpene lactones. [Mh] Termos MeSH primário: Frutas/química Lactonas/isolamento & purificação Lactonas/farmacologia Sesquiterpenos/isolamento & purificação Sesquiterpenos/farmacologia Xanthium/química [Mh] Termos MeSH secundário: Seres Humanos Concentração Inibidora 50 Lactonas/química Estrutura Molecular Sesquiterpenos/química [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Lactones); 0 (Sesquiterpenes); 0 (pungiolide F) [Em] Mês de entrada: 1702 [Cu] Atualização por classe: 171129 [Lr] Data última revisão: 171129 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 161025 [St] Status: MEDLINE

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[PMID]: 28412621 [Au] Autor: Khamparia S; Jaspal DK [Ad] Endereço: Symbiosis Centre for Research and Innovation, Symbiosis International University, Lavale, Pune 412115, India. Electronic address: shraddha.khamparia@sitpune.edu.in. [Ti] Título: Xanthium strumarium L. seed hull as a zero cost alternative for Rhodamine B dye removal. [So] Source: J Environ Manage;197:498-506, 2017 Jul 15. [Is] ISSN: 1095-8630 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: Treatment of polluted water has been considered as one of the most important aspects in environmental sciences. Present study explores the decolorization potential of a low cost natural adsorbent Xanthium strumarium L. seed hull for the adsorption of a toxic xanthene dye, Rhodamine B (RHB). The characterization of the adsorbent revealed the presence of high amount of carbon, when exposed to Electron Dispersive Spectroscopy (EDS). Further appreciable decolorization took place which was confirmed by Fourier Transform Infrared Spectroscopy (FTIR) analysis noticing shift in peaks. Isothermal studies indicated multilayer adsorption following Freundlich isotherm. The rate of adsorption was supported by second order kinetics directing a chemical phenomenon during the process with dominance of film diffusion as the rate governing step. Moreover paper aims at correlating the chemical arena to the mathematical aspect providing an in-depth information of the studied treatment process. For proper assessment and validation of the observed data, experimental data has been statistically treated by applying different error functions namely, Chi-square test (χ ), Sum of absolute errors (EABS) and Normalized standard deviation (NSD). Further practical applicability of the low cost adsorbent was evaluated by continuous column mode studies with 72.2% of dye recovery. Xanthium strumarium L. proved to be environment friendly low cost natural adsorbent for decolorizing RHB from aquatic system. [Mh] Termos MeSH primário: Rodaminas Purificação da Água Xanthium [Mh] Termos MeSH secundário: Adsorção Concentração de Íons de Hidrogênio Cinética Espectroscopia de Infravermelho com Transformada de Fourier Poluentes Químicos da Água [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Rhodamines); 0 (Water Pollutants, Chemical); K7G5SCF8IL (rhodamine B) [Em] Mês de entrada: 1711 [Cu] Atualização por classe: 171113 [Lr] Data última revisão: 171113 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170417 [St] Status: MEDLINE

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[PMID]: 28333449 [Au] Autor: Li G; Kusari S; Golz C; Laatsch H; Strohmann C; Spiteller M [Ad] Endereço: Institute of Environmental Research (INFU), Department of Chemistry and Chemical Biology, Chair of Environmental Chemistry and Analytical Chemistry, TU Dortmund , Otto-Hahn-Straße 6, 44221 Dortmund, Germany. [Ti] Título: Epigenetic Modulation of Endophytic Eupenicillium sp. LG41 by a Histone Deacetylase Inhibitor for Production of Decalin-Containing Compounds. [So] Source: J Nat Prod;80(4):983-988, 2017 Apr 28. [Is] ISSN: 1520-6025 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: An endophytic fungus, Eupenicillium sp. LG41, isolated from the Chinese medicinal plant Xanthium sibiricum, was subjected to epigenetic modulation using an NAD -dependent histone deacetylase (HDAC) inhibitor, nicotinamide. Epigenetic stimulation of the endophyte led to enhanced production of two new decalin-containing compounds, eupenicinicols C and D (3 and 4), along with two biosynthetically related known compounds, eujavanicol A (1) and eupenicinicol A (2). The structures and stereochemistry of the new compounds were elucidated by extensive spectroscopic analysis using LC-HRMS, NMR, optical rotation, and ECD calculations, as well as single-crystal X-ray diffraction. Compounds 3 and 4 exist in chemical equilibrium with two and three cis/trans isomers, respectively, as revealed by LC-MS analysis. Compound 4 was active against Staphylococcus aureus with an MIC of 0.1 µg/mL and demonstrated marked cytotoxicity against the human acute monocytic leukemia cell line (THP-1). We have shown that the HDAC inhibitor, nicotinamide, enhanced the production of compounds 3 and 4 by endophytic Eupenicillium sp. LG41, facilitating their isolation, structure elucidation, and evaluation of their biological activities. [Mh] Termos MeSH primário: Eupenicillium/química Inibidores de Histona Desacetilases/farmacologia Naftalenos/química Xanthium/microbiologia [Mh] Termos MeSH secundário: Antibacterianos/química Bacillus subtilis/efeitos dos fármacos Cristalografia por Raios X Medicamentos de Ervas Chinesas/química Endófitos/química Seres Humanos Testes de Sensibilidade Microbiana Estrutura Molecular Naftalenos/isolamento & purificação Naftalenos/farmacologia Ressonância Magnética Nuclear Biomolecular Penicillium/química Staphylococcus aureus/efeitos dos fármacos [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Anti-Bacterial Agents); 0 (Drugs, Chinese Herbal); 0 (Histone Deacetylase Inhibitors); 0 (Naphthalenes); 0 (eujavanicol A); 0 (eupenicinicol A); 88451Q4XYF (decalin) [Em] Mês de entrada: 1707 [Cu] Atualização por classe: 170726 [Lr] Data última revisão: 170726 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170324 [St] Status: MEDLINE [do] DOI: 10.1021/acs.jnatprod.6b00997

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[PMID]: 28202456 [Au] Autor: Oikawa S; Suno K; Osada N [Ad] Endereço: Graduate School of Science and Engineering, Ibaraki University, Mito 310-0056 Japan shimpei.oikawa.dx@vc.ibaraki.ac.jp. [Ti] Título: Inconsistent intraspecific pattern in leaf life span along nitrogen-supply gradient. [So] Source: Am J Bot;104(2):342-346, 2017 Feb. [Is] ISSN: 1537-2197 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: PREMISE OF THE STUDY: Leaf life span (LLS) has long been hypothesized to plastically increase with decreasing nitrogen (N) supply from soil to maximize N retention, carbon assimilation, and fitness; however, accumulating evidence shows no consistent trend. The apparent inconsistencies are explained by a recent model that assumes LLS has a hump-shaped quadratic response to the N-supply gradient. The available evidence mostly originates from comparisons of LLS at only two levels of N availability, and the hypothesis remains unanswered. METHODS: We investigated LLS of two asteraceous forbs ( and ) experimentally grown at eight levels of N supply, which covered a range of N supply in their natural habitats. We additionally conducted a literature search to retrieve studies reporting LLS response along an N-supply gradient. KEY RESULTS: The LLS of neither species showed a hump-shaped response along the N-supply gradient. Past studies examining the LLS of an aquatic forb and terrestrial shrubs and trees along the N-supply gradient (more than four levels of N supply) also refuted the hypothesis. CONCLUSIONS: The LLS of a single species exhibited neither an increase nor a hump-shaped response to decreased N supply in a variety of life forms. Comparisons at only a few N levels are misleading with regard to LLS response to N supply. [Mh] Termos MeSH primário: Carbono/metabolismo Nitrogênio/metabolismo Folhas de Planta/metabolismo Solo/química [Mh] Termos MeSH secundário: Asteraceae/metabolismo Asteraceae/fisiologia Ecossistema Modelos Biológicos Especificidade da Espécie Xanthium/metabolismo Xanthium/fisiologia [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Soil); 7440-44-0 (Carbon); N762921K75 (Nitrogen) [Em] Mês de entrada: 1708 [Cu] Atualização por classe: 171116 [Lr] Data última revisão: 171116 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170217 [St] Status: MEDLINE [do] DOI: 10.3732/ajb.1600435

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[PMID]: 28073395 [Au] Autor: Wang W; Wang B; Meng H; Xing Z; Lai Q; Yuan L [Ad] Endereço: 1​School of Basic Medical Sciences, North China University of Science and Technology, Hebei Key Laboratory for Chronic Diseases, Tangshan Key Laboratory for Preclinical and Basic Research on Chronic Diseases, Tangshan 063009, PR China. [Ti] Título: Actinophytocola xanthii sp. nov., an actinomycete isolated from rhizosphere soil of the plant Xanthium sibiricum. [So] Source: Int J Syst Evol Microbiol;67(5):1152-1157, 2017 May. [Is] ISSN: 1466-5034 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: A novel actinomycete strain, 11-183T, was isolated from the rhizosphere soil of Xanthium sibiricum, which was collected in Tangshan, Hebei, China. A phylogenetic analysis based on 16S rRNA gene sequences showed that strain 11-183T formed a clade within the genus Actinophytocola, with a maximum similarity of 98.44 % to Actinophytocola xinjiangensis QAIII60T, followed by 97.76 % similarity to Actinophytocola sediminis YIM M13705T. The average nucleotide identity and digital DNA-DNA hybridization values differed by 79.24 and 23.4 %, respectively, between strain 11-183T and Actinophytocolaxinjiangensis QAIII60T. Strain 11-183T grew well on N-Z-amine agar, and it produced a scant, white aerial mycelium. The isolate formed pale yellow to brown-black colonies and a dense, non-fragmented, branched substrate mycelium, and produced aerial hyphae on which nodular spore chains formed. Growth was observed at salinities ranging from 0 to 2 %, at pH values ranging from pH 6.5 to 8.0 and at temperatures ranging from 15 to 37 °C. The cell-wall amino acids included meso-diaminopimelic acid. Whole cell hydrolysates contained galactose and glucose. The principal fatty acids were iso-C16 : 0, iso-C16 : 1 H and C17 : 1ω6c. Diphosphatidylglycerol, phosphatidylmonomethylethanolamine and phosphatidylethanolamine were the diagnostic phospholipids. The isoprenoid quinones included MK-9(H4) and MK-10(H4). The G+C content of the genomic DNA was 71.7 mol%. Based on the genotypic and phenotypic data, we conclude that strain 11-183T belongs to a novel species of the genus Actinophytocola. The name proposed for the novel species is Actinophytocola xanthii sp. nov., with the type strain 11-183T (=KCTC 39690T= MCCC 1K02062T). [Mh] Termos MeSH primário: Actinomycetales/classificação Filogenia Rizosfera Microbiologia do Solo Xanthium/microbiologia [Mh] Termos MeSH secundário: Actinomycetales/genética Actinomycetales/isolamento & purificação Técnicas de Tipagem Bacteriana Composição de Bases China DNA Bacteriano/genética Ácido Diaminopimélico/química Ácidos Graxos/química Hibridização de Ácido Nucleico Fosfolipídeos/química RNA Ribossômico 16S/genética Análise de Sequência de DNA Vitamina K 2/análogos & derivados Vitamina K 2/química [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (DNA, Bacterial); 0 (Fatty Acids); 0 (Phospholipids); 0 (RNA, Ribosomal, 16S); 11032-49-8 (Vitamin K 2); 523-39-7 (menaquinone 9); 583-93-7 (Diaminopimelic Acid) [Em] Mês de entrada: 1708 [Cu] Atualização por classe: 170824 [Lr] Data última revisão: 170824 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170112 [St] Status: MEDLINE [do] DOI: 10.1099/ijsem.0.001781

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[PMID]: 28017814 [Au] Autor: Jiang H; Yang L; Ma GX; Xing XD; Yan ML; Zhang YY; Wang QH; Yang BY; Kuang HX; Xu XD [Ad] Endereço: Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100193, PR China; Key Laboratory of Chinese MateriaMedica, Heilo [Ti] Título: New phenylpropanoid derivatives from the fruits of Xanthium sibiricum and their anti-inflammatory activity. [So] Source: Fitoterapia;117:11-15, 2017 Mar. [Is] ISSN: 1873-6971 [Cp] País de publicação: Netherlands [La] Idioma: eng [Ab] Resumo: The fruits of Xanthium sibiricum Patr yielded five phenylpropanoid derivatives, named as xanthiumnolics A-E (1-5). Their structures were elucidated by spectroscopic analysis and comparison with literature data. The isolated ones were tested for their anti-inflammatory activities on lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW 264.7, and compound 5 showed strong inhibitory activities with IC value of 8.73µM. [Mh] Termos MeSH primário: Anti-Inflamatórios/química Frutas/química Macrófagos/efeitos dos fármacos Compostos Fitoquímicos/química Xanthium/química [Mh] Termos MeSH secundário: Animais Anti-Inflamatórios/isolamento & purificação Lipopolissacarídeos Camundongos Estrutura Molecular Óxido Nítrico/química Compostos Fitoquímicos/isolamento & purificação Extratos Vegetais/química Células RAW 264.7 [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Anti-Inflammatory Agents); 0 (Lipopolysaccharides); 0 (Phytochemicals); 0 (Plant Extracts); 31C4KY9ESH (Nitric Oxide) [Em] Mês de entrada: 1703 [Cu] Atualização por classe: 170307 [Lr] Data última revisão: 170307 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 161227 [St] Status: MEDLINE

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[PMID]: 27686750 [Au] Autor: Taranto AG; Costa SC; Leite FH; de Sá MS; Soares MB; Mussi MM; Branco A [Ad] Endereço: a Laboratório de Química Farmacêutica Medicinal , Universidade Federal de São João del-Rei , Divinópolis , Brazil. [Ti] Título: Caffeoylquinic acids from antiplasmodial active extract of Xanthium cavanillesii fruits and their molecular modelling studies. [So] Source: Nat Prod Res;31(6):729-733, 2017 Mar. [Is] ISSN: 1478-6427 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: The antiplasmodial active extract of Xanthium cavanillesii contains 3,4-dicaffeoyl quinic acid (3,4-DCQA), 3,5-dicaffeoyl quinic acid (3,5-DCQA) and 1,3,5-tricaffeoyl quinic acid (1,3,5-TCQA). These results inspired us to investigate the interaction of these molecules with a promising validated target of Plasmodium, PfATP6 orthologue of mammalian Ca -ATPase. Models of this receptor were obtained through comparative modelling. Afterwards, molecular docking studies were used to identify possible interaction modes of these caffeoyl quinic derivatives on the binding site. The 1,3,5-TCQA had the best energy, but all of these had better energy than thapsigargin, a non-competitive inhibitor of the sarco/endoplasmatic reticulum Ca -ATPase (SERCA). [Mh] Termos MeSH primário: Antimaláricos/farmacologia Frutas/química Extratos Vegetais/farmacologia Ácido Quínico/análogos & derivados Xanthium/química [Mh] Termos MeSH secundário: Animais Antimaláricos/química ATPases Transportadoras de Cálcio/antagonistas & inibidores Inibidores Enzimáticos/farmacologia Modelos Moleculares Simulação de Acoplamento Molecular Extratos Vegetais/química Plasmodium/efeitos dos fármacos Ácido Quínico/química Ácido Quínico/farmacologia Tapsigargina/farmacologia [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Antimalarials); 0 (Enzyme Inhibitors); 0 (Plant Extracts); 0 (caffeoylquinic acid); 058C04BGYI (Quinic Acid); 67526-95-8 (Thapsigargin); EC 3.6.3.8 (Calcium-Transporting ATPases) [Em] Mês de entrada: 1705 [Cu] Atualização por classe: 170817 [Lr] Data última revisão: 170817 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 161001 [St] Status: MEDLINE [do] DOI: 10.1080/14786419.2016.1219856

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[PMID]: 27545965 [Au] Autor: Andreani S; Paolini J; Costa J; Muselli A [Ad] Endereço: Laboratoire Chimie des Produits Naturels, UMR CNRS 6134 SPE, Université de Corse, BP 52, FR-20250, Corte. [Ti] Título: Chemical Composition of Essential Oils of Xanthium spinosum L., an Invasive Species of Corsica. [So] Source: Chem Biodivers;14(1), 2017 Jan. [Is] ISSN: 1612-1880 [Cp] País de publicação: Switzerland [La] Idioma: eng [Ab] Resumo: Xanthium spinosum L. is a highly invasive plant originated from South America throughout the world as well as in Corsica Island. The chemical composition of X. spinosum essential oils from 25 Corsican locations was investigated using GC-FID and GC/MS. Seventy-four components, which accounted for 96.2% of the total amount, were reported for the first time in the essential oil from aerial parts. The main compounds were eudesma-4(14),7-dien-1ß-ol (61; 21.3%), germacrene D (36; 8.8%) and cadalene (60; 8.7%). Comparison with the literature highlighted the originality of the Corsican essential oil and eudesma-4(14),7-dien-1ß-ol could be used as taxonomical marker to the systematics of the Xanthium genus. The essential oils obtained from separate organs and during the plant vegetative cycle were also studied to gain more knowledge about the correlations between the volatile production and the phenological states of this weed. The production of oxygenated sesquiterpenes was predominant during the plant-flowering process. The study focuses on direct correlation between the chemical composition of individual 25 oil samples and the morphological differences of the plant. Our results have gained more knowledge about the secondary metabolite production that occurs during the plant life, they could be interesting in order to manage the dispersal of X. spinosum. [Mh] Termos MeSH primário: Óleos Voláteis/química Xanthium/química [Mh] Termos MeSH secundário: França Cromatografia Gasosa-Espectrometria de Massas Espécies Introduzidas Componentes Aéreos da Planta/química Óleos Vegetais/química [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Oils, Volatile); 0 (Plant Oils) [Em] Mês de entrada: 1701 [Cu] Atualização por classe: 170127 [Lr] Data última revisão: 170127 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 160823 [St] Status: MEDLINE [do] DOI: 10.1002/cbdv.201600148

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[PMID]: 27876212 [Au] Autor: Panigrahi PN; Dey S; Sahoo M; Choudhary SS; Mahajan S [Ad] Endereço: Division of Medicine, Indian Veterinary Research Institute, Izatnagar, Bareilly Uttar Pradesh-243122, India; Division of Medicine, Faculty of Veterinary and Animal Science, Banaras Hindu University, Varanasi, Uttar Pradesh-221005, India. Electronic address: pnpvetmed@gmail.com. [Ti] Título: Alteration in Oxidative/nitrosative imbalance, histochemical expression of osteopontin and antiurolithiatic efficacy of Xanthium strumarium (L.) in ethylene glycol induced urolithiasis. [So] Source: Biomed Pharmacother;84:1524-1532, 2016 Dec. [Is] ISSN: 1950-6007 [Cp] País de publicação: France [La] Idioma: eng [Ab] Resumo: Xanthium strumarium has traditionally been used in the treatment of urolitiasis especially by the rural people in India, but its antiurolithiatic efficacy was not explored scientifically till now. Therefore, the present study was designed to validate the ethnic practice scientifically, and explore the possible antiurolithiatic effect to rationalize its medicinal use. Urolitiasis was induced in hyperoxaluric rat model by giving 0.75% ethylene glycol (EG) for 28days along with 1% ammonium chloride (AC) for first 14days. Antiurolithiatic effect of aqueous-ethanol extract of Xanthium strumarium bur (xanthium) was evaluated based on urine and serum biochemistry, oxidative/nitrosative stress indices, histopathology, kidney calcium and calcium oxalate content and immunohistochemical expression of matrix glycoprotein, osteopontin (OPN). Administration of EG and AC resulted in hyperoxaluria, crystalluria, hypocalciuria, polyurea, raised serum urea, creatinine, erythrocytic lipid peroxidise and nitric oxide, kidney calcium content as well as crystal deposition in kidney section in lithiatic group rats. However, xanthium treatment significantly restored the impairment in above kidney function test as that of standard treatment, cystone. The up-regulation of OPN was also significantly decreased after xanthium treatment. The present findings demonstrate the curative efficacy of xanthium in ethylene glycol induced urolithiasis, possibly mediated through inhibition of various pathways involved in renal calcium oxalate formation, antioxidant property and down regulation of matrix glycoprotein, OPN. Therefore, future studies may be established to evaluate its efficacy and safety for clinical use. [Mh] Termos MeSH primário: Etilenoglicol/toxicidade Osteopontina/biossíntese Estresse Oxidativo/fisiologia Extratos Vegetais/uso terapêutico Urolitíase/metabolismo Xanthium [Mh] Termos MeSH secundário: Animais Masculino Nitrosação/efeitos dos fármacos Nitrosação/fisiologia Osteopontina/química Estresse Oxidativo/efeitos dos fármacos Extratos Vegetais/isolamento & purificação Extratos Vegetais/farmacologia Ratos Ratos Wistar Urolitíase/induzido quimicamente Urolitíase/tratamento farmacológico [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Plant Extracts); 0 (Spp1 protein, rat); 106441-73-0 (Osteopontin); FC72KVT52F (Ethylene Glycol) [Em] Mês de entrada: 1702 [Cu] Atualização por classe: 170921 [Lr] Data última revisão: 170921 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 161124 [St] Status: MEDLINE

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[PMID]: 27840259 [Au] Autor: Sánchez-Lamar A; Piloto-Ferrer J; Fiore M; Stano P; Cozzi R; Tofani D; Cundari E; Francisco M; Romero A; González ML; Degrassi F [Ad] Endereço: Departamento de Biología Vegetal, Laboratorio de Toxicología Genética, Facultad de Biología, Universidad de la Habana, Calle 25, No. 455, e/ I y J, Vedado, La Habana, Cuba. Electronic address: alamar@fbio.uh.cu. [Ti] Título: Xanthium strumarium extract inhibits mammalian cell proliferation through mitotic spindle disruption mediated by xanthatin. [So] Source: J Ethnopharmacol;194:781-788, 2016 Dec 24. [Is] ISSN: 1872-7573 [Cp] País de publicação: Ireland [La] Idioma: eng [Ab] Resumo: ETHNOPHARMACOLOGICAL RELEVANCE: Xanthium strumarium L. is a member of the Asteraceae family popularly used with multiple therapeutic purposes. Whole extracts of this plant have shown anti-mitotic activity in vitro suggesting that some components could induce mitotic arrest in proliferating cells. AIM OF THE SUDY: Aim of the present work was to characterize the anti-mitotic properties of the X. strumarium whole extract and to isolate and purify active molecule(s). MATERIALS AND METHODS: The capacity of the whole extract to inhibit mitotic progression in mammalian cultured cells was investigated to identify its anti-mitotic activity. Isolation of active component(s) was performed using a bioassay-guided multistep separation procedure in which whole extract was submitted to a progressive process of fractionation and fractions were challenged for their anti-mitotic activity. RESULTS: Our results show for the first time that X. strumarium whole extract inhibits assembly of the mitotic spindle and spindle-pole separation, thereby heavily affecting mitosis, impairing the metaphase to anaphase transition and inducing apoptosis. The purification procedure led to a fraction with an anti-mitotic activity comparable to that of the whole extract. Chemical analysis of this fraction showed that its major component was xanthatin. CONCLUSIONS: The present work shows a new activity of X. strumarium extract, i.e. the alteration of the mitotic apparatus in cultured cells that may be responsible for the anti-proliferative activity of the extract. Anti-mitotic activity is shown to be mainly exerted by xanthatin. [Mh] Termos MeSH primário: Proliferação Celular/efeitos dos fármacos Furanos/química Furanos/farmacologia Extratos Vegetais/química Extratos Vegetais/farmacologia Fuso Acromático/efeitos dos fármacos Xanthium/química [Mh] Termos MeSH secundário: Animais Apoptose/efeitos dos fármacos Células CHO Linhagem Celular Cricetulus [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Furans); 0 (Plant Extracts); 298X1N12LS (xanthatin) [Em] Mês de entrada: 1704 [Cu] Atualização por classe: 170411 [Lr] Data última revisão: 170411 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 161115 [St] Status: MEDLINE

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2	and or and not		PalavrasDescritor de assuntoDescritor de assunto primárioLimitesAutorPalavras do títuloPalavras do resumoIdiomaPaís de publicaçãoNome de substânciaNome de pessoa como assuntoRevistaAssunto de RevistaISSNTipo de publicaçãoIdentificador únicoMês de entradaAno de publicaçãoTexto completoAtualização por classeCategoria DeCSCategoria DeCS explodidaCategoria CID-10SubSetsPais de AfiliaçãoAfiliaçãoAfiliação 2
3	and or and not		PalavrasDescritor de assuntoDescritor de assunto primárioLimitesAutorPalavras do títuloPalavras do resumoIdiomaPaís de publicaçãoNome de substânciaNome de pessoa como assuntoRevistaAssunto de RevistaISSNTipo de publicaçãoIdentificador únicoMês de entradaAno de publicaçãoTexto completoAtualização por classeCategoria DeCSCategoria DeCS explodidaCategoria CID-10SubSetsPais de AfiliaçãoAfiliaçãoAfiliação 2

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