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Pesquisa : B01.650.940.800.575.912.250.125.249 [Categoria DeCS]
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[PMID]:28720131
[Au] Autor:Alamgeer; Uttra AM; Hasan UH
[Ad] Endereço:Laboratory of Cardiovascular Research and Integrative Pharmacology, Department of Pharmacology, Faculty of Pharmacy, University Of Sargodha, Sargodha, Pakistan. alam_yuchi@yahoo.com.
[Ti] Título:Anti-arthritic activity of aqueous-methanolic extract and various fractions of Berberis orthobotrys Bien ex Aitch.
[So] Source:BMC Complement Altern Med;17(1):371, 2017 Jul 18.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The roots and stem bark of Berberis orthobotrys (Berberidaceae) have long been used traditionally to treat joint pain. Though, it has not been pharmacologically assessed for rheumatoid arthritis. The current study explores anti-arthritic activity and phytochemical analysis of aqueous-methanolic extract (30:70) and fractions (ethyl acetate, n-butanol, and aqueous) of Berberis orthobotrys roots. METHODS: Anti-arthritic potential was evaluated in vitro using protein denaturation (bovine serum albumin and egg albumin) and membrane stabilization methods at 12.5-800 µg/ml concentration and in vivo via turpentine oil, formaldehyde and Complete Freund Adjuvant (CFA) models at 50, 100 and 150 mg/kg doses. Also, in vitro antioxidant ability was appraised by reducing power assay. Moreover, total flavonoid content, Fourier transform infrared spectroscopy and High performance liquid chromatography of n-butanol fraction were performed. RESULTS: The results revealed concentration dependent inhibition of albumin denaturation and notable RBC membrane stabilization, with maximum results obtained at 800 µg/ml. Similarly, plant exhibited dose dependent anti-arthritic effect in turpentine oil and formaldehyde models, with maximum activity observed at 150 mg/kg. The results of CFA model depicted better protection against arthritic lesions and body weight alterations. Also, B.orthobotrys remarkably ameliorated altered hematological parameters, rheumatoid factor and positively modified radiographic and histopathological changes. Additionally, plant exhibited remarkable anti-oxidant activity. Moreover, phytochemical analysis revealed polyphenols and flavonoids. CONCLUSION: Taken together, these results support traditional use of B.orthobotrys as potent anti-arthritic agent that may be proposed for rheumatoid arthritis treatment.
[Mh] Termos MeSH primário: Antirreumáticos/uso terapêutico
Artrite Experimental/tratamento farmacológico
Artrite Reumatoide
Berberis/química
Fitoterapia
Extratos Vegetais/uso terapêutico
Polifenóis/uso terapêutico
[Mh] Termos MeSH secundário: Albuminas/metabolismo
Animais
Antioxidantes/análise
Antioxidantes/farmacologia
Antioxidantes/uso terapêutico
Antirreumáticos/farmacologia
Artrite Reumatoide/sangue
Artrite Reumatoide/tratamento farmacológico
Bovinos
Membrana Celular/efeitos dos fármacos
Eritrócitos
Feminino
Flavonoides/análise
Flavonoides/farmacologia
Flavonoides/uso terapêutico
Formaldeído
Adjuvante de Freund
Masculino
Extratos Vegetais/química
Extratos Vegetais/farmacologia
Estruturas Vegetais
Polifenóis/análise
Polifenóis/farmacologia
Desnaturação Proteica
Ratos Sprague-Dawley
Fator Reumatoide/sangue
Albumina Sérica/metabolismo
Terebintina
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Albumins); 0 (Antioxidants); 0 (Antirheumatic Agents); 0 (Flavonoids); 0 (Plant Extracts); 0 (Polyphenols); 0 (Serum Albumin); 1HG84L3525 (Formaldehyde); 8006-64-2 (Turpentine); 9007-81-2 (Freund's Adjuvant); 9009-79-4 (Rheumatoid Factor)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170901
[Lr] Data última revisão:
170901
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170720
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-1879-9


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[PMID]:28685558
[Au] Autor:Guarino G; Strollo F; Carbone L; Della Corte T; Letizia M; Marino G; Gentile S
[Ad] Endereço:Department of Clinical and Experimental Medicine, University of Campania “Luigi Vanvitelli”, Naples, Italy.
[Ti] Título:Bioimpedance analysis, metabolic effects and safety of the association Berberis aristata/Bilybum marianum: a 52-week double-blind, placebo-controlled study in obese patients with type 2 diabetes.
[So] Source:J Biol Regul Homeost Agents;31(2):495-502, 2017 Apr-Jun.
[Is] ISSN:0393-974X
[Cp] País de publicação:Italy
[La] Idioma:eng
[Ab] Resumo:Berberine, a quaternary isoquinoline alkaloid present in Berberis aristata, is well known in terms of cholesterol-lowering, hypoglycemic, and insulin sensitizing effects. Because of its low oral bioavailability, to improve intestinal absorption it has been recently combined with silymarin (Silybum marianum). The aim of our placebo controlled study was to evaluate the effects of its association with silymarin on abdominal fat in overweight/obese patients with type 2 diabetes mellitus (T2DM). To do so, 136 obese subjects with T2DM and metabolic syndrome were analyzed for fasting blood glucose and insulin, Insulin Resistance index according to the Homeostatic Model Assessment (HOMA-R), total, HDL and LDL cholesterol, triglycerides, uric acid, BMI, waist circumference, waist to hip ratio and underwent bioelectrical impedance to assess % of abdominal fat. All the above-mentioned parameters, as recorded at enrollment, after 6 months and at the end of the study, had significantly improved in the BBR-treated group in respect to baseline and to the control group. A validated national cardiovascular risk score also improved significantly after BBR treatment in respect to placebo. Our results point to a clinically significant effect in obese people with T2DM and metabolic syndrome. Moreover, for the first time, they provide evidence of a significant uric acid lowering activity as an additive beneficial effect of the association BBR + silymarin.
[Mh] Termos MeSH primário: Berberina/administração & dosagem
Berberis/química
Diabetes Mellitus Tipo 2/tratamento farmacológico
Síndrome Metabólica/tratamento farmacológico
Cardo Mariano/química
Obesidade/tratamento farmacológico
Silimarina/administração & dosagem
[Mh] Termos MeSH secundário: Idoso
Berberina/química
Diabetes Mellitus Tipo 2/sangue
Diabetes Mellitus Tipo 2/patologia
Diabetes Mellitus Tipo 2/fisiopatologia
Método Duplo-Cego
Impedância Elétrica
Feminino
Seres Humanos
Lipídeos/sangue
Masculino
Síndrome Metabólica/sangue
Síndrome Metabólica/patologia
Síndrome Metabólica/fisiopatologia
Meia-Idade
Obesidade/sangue
Obesidade/patologia
Obesidade/fisiopatologia
Silimarina/química
Ácido Úrico/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Lipids); 0 (Silymarin); 0I8Y3P32UF (Berberine); 268B43MJ25 (Uric Acid)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170708
[St] Status:MEDLINE


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[PMID]:28514949
[Au] Autor:Zoric N; Kosalec I; Tomic S; Bobnjaric I; Jug M; Vlainic T; Vlainic J
[Ad] Endereço:Agency for Medicinal Products and Medical Devices of Croatia, Ksaverska cesta 4, 10000, Zagreb, HR, Croatia.
[Ti] Título:Membrane of Candida albicans as a target of berberine.
[So] Source:BMC Complement Altern Med;17(1):268, 2017 May 17.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: We investigated the mechanisms of anti-Candida action of isoquinoline alkaloid berberine, active constituent of medically important plants of Barberry species. METHODS: The effects on membrane, morphological transition, synthesis of ergosterol and the consequent changes in membrane permeability have been studied. Polarization and lipid peroxidation level of the membrane following berberine treatment have been addressed. RESULTS: Minimal inhibitory concentration (MIC) of berberine against C. albicans was 17.75 µg/mL. Cytotoxic effect of berberine was concentration dependent, and in sub-MIC concentrations inhibit morphological transition of C. albicans cells to its filamentous form. Results showed that berberine affects synthesis of membrane ergosterol dose-dependently and induces increased membrane permeability causing loss of intracellular material to the outer space (DNA/protein leakage). Berberine also caused membrane depolarization and lipid peroxidation of membrane constituents indicating its direct effect on the membrane. Moreover, ROS levels were also increased following berberine treatment indicating further the possibility of membrane damage. CONCLUSION: Based on the obtained results it seems that berberine achieves its anti-Candida activity by affecting the cell membrane.
[Mh] Termos MeSH primário: Antifúngicos/farmacologia
Berberina/farmacologia
Berberis/química
Candida albicans/efeitos dos fármacos
Membrana Celular/efeitos dos fármacos
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Candida albicans/metabolismo
Candidíase/microbiologia
Membrana Celular/metabolismo
Permeabilidade da Membrana Celular/efeitos dos fármacos
Seres Humanos
Testes de Sensibilidade Microbiana
Espécies Reativas de Oxigênio/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antifungal Agents); 0 (Plant Extracts); 0 (Reactive Oxygen Species); 0I8Y3P32UF (Berberine)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170821
[Lr] Data última revisão:
170821
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170519
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-1773-5


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[PMID]:28407963
[Au] Autor:Belwal T; Giri L; Bhatt ID; Rawal RS; Pande V
[Ad] Endereço:G.B. Pant National Institute of Himalayan Environment and Sustainable Development, Kosi Katarmal, Almora-263643, Uttarakhand, India.
[Ti] Título:An improved method for extraction of nutraceutically important polyphenolics from Berberis jaeschkeana C.K. Schneid. fruits.
[So] Source:Food Chem;230:657-666, 2017 Sep 01.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Berberis jaeschkeana fruits, source of nutraceutically important polyphenolics were investigated. A total of 32 experimental run were conducted under Plackett-Burman and central composite design. Microwave power, methanol and HCl concentration significantly (p<0.05) affect extraction of polyphenols under linear, quadratic and interactive effect. The model showed good fitness with significant (p<0.05) model F-value and a non-significant lack of fit. Under optimum microwave assisted extraction (MAE) condition the total phenolics, flavonoids, tannins and antioxidant activity were in closed context with predicted values. As compared to ultrasonic (UAE) and maceration extraction (ME), MAE showed significantly (p<0.05) higher recovery of TP, TF and FRAP antioxidant activity. HPLC-DAD analysis detects a total of 10 polyphenolic compounds under MAE as compared to 9 under UAE and ME. Designing of MAE conditions showed promising results for polyphenolic antioxidants extraction as revealed by higher yield with lesser time and solvent consumption, which can contribute in green extraction technology and its application in nutraceutical industry.
[Mh] Termos MeSH primário: Berberis/química
Frutas/química
Extratos Vegetais/química
Polifenóis/química
[Mh] Termos MeSH secundário: Antioxidantes/análise
Suplementos Nutricionais/análise
Flavonoides/análise
Oxirredução
Extratos Vegetais/análise
Polifenóis/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Flavonoids); 0 (Plant Extracts); 0 (Polyphenols)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170512
[Lr] Data última revisão:
170512
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170415
[St] Status:MEDLINE


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[PMID]:28195545
[Au] Autor:Laamech J; El-Hilaly J; Fetoui H; Chtourou Y; Gouitaa H; Tahraoui A; Lyoussi B
[Ti] Título:Berberis vulgaris L. effects on oxidative stress and liver injury in lead-intoxicated mice.
[So] Source:J Complement Integr Med;14(1), 2017 Mar 01.
[Is] ISSN:1553-3840
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Background Berberis vulgaris L. (BV), commonly known as "Aghriss" in Moroccan pharmacopoeia, is used to cure liver disorders and other diseases. The present study aimed to investigate the protective effect of BV aqueous extract against lead-induced toxicity in mice liver. Methods Sixty IOPS mice were divided into six groups and were treated as follows: group 1 (normal control) received double distilled water; group 2 (toxic control) received lead acetate (5 mg/kg body weight/day) in double distilled water for 40 days; groups 3-6 received BV aqueous extract at doses of 25, 50, 100 and 150 mg/kg body weight , respectively, once daily for 30 days from 11 day after beginning of lead acetate exposure to the end of the experiment. Results Toxic control group showed a significant alteration of serum alanine-aminotransferase (ALT), aspartate-aminotransferase (AST), total cholesterol (TC), total bilirubin (TB), catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx) and reduced glutathione (GSH). Histological assessment of lead-intoxicated mice liver revealed alterations in hepatocytes and focal necrosis. BV treatment significantly prevented lead accumulation, increased ALT, AST, TC, and TB, inhibited lipid peroxidation and protein carbonyls(PCO) formation. Additionally, BV extract normalized the antioxidant enzymes (CAT, SOD and GPx), GSH and architecture of liver tissues. Conclusions BV aqueous extract exerts significant hepatoprotective effects against lead-induced oxidative stress and liver dysfunction. The BV effect may be mediated through the enhancement of antioxidant status, lead-chelating abilities and free radicals quenching.
[Mh] Termos MeSH primário: Antioxidantes/uso terapêutico
Berberis
Doença Hepática Induzida por Substâncias e Drogas/tratamento farmacológico
Chumbo/efeitos adversos
Fígado/efeitos dos fármacos
Estresse Oxidativo/efeitos dos fármacos
Fitoterapia
[Mh] Termos MeSH secundário: Alanina Transaminase/sangue
Animais
Antioxidantes/metabolismo
Antioxidantes/farmacologia
Aspartato Aminotransferases/sangue
Bilirrubina/sangue
Catalase/sangue
Doença Hepática Induzida por Substâncias e Drogas/sangue
Doença Hepática Induzida por Substâncias e Drogas/patologia
Colesterol/sangue
Glutationa/sangue
Glutationa Peroxidase/sangue
Chumbo/sangue
Chumbo/toxicidade
Peroxidação de Lipídeos/efeitos dos fármacos
Fígado/enzimologia
Fígado/patologia
Masculino
Camundongos
Extratos Vegetais/farmacologia
Extratos Vegetais/uso terapêutico
Carbonilação Proteica/efeitos dos fármacos
Superóxido Dismutase/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Plant Extracts); 2P299V784P (Lead); 97C5T2UQ7J (Cholesterol); EC 1.11.1.6 (Catalase); EC 1.11.1.9 (Glutathione Peroxidase); EC 1.15.1.1 (Superoxide Dismutase); EC 2.6.1.1 (Aspartate Aminotransferases); EC 2.6.1.2 (Alanine Transaminase); GAN16C9B8O (Glutathione); RFM9X3LJ49 (Bilirubin)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170809
[Lr] Data última revisão:
170809
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170215
[St] Status:MEDLINE


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[PMID]:28178209
[Au] Autor:Derosa G; D'Angelo A; Romano D; Maffioli P
[Ad] Endereço:Centre of Diabetes and Metabolic Diseases, Department of Internal Medicine and Therapeutics, University of Pavia and Fondazione IRCCS Policlinico San Matteo, 27100 Pavia, Italy. giuseppe.derosa@unipv.it.
[Ti] Título:Effects of a Combination of Berberis aristata, Silybum marianum and Monacolin on Lipid Profile in Subjects at Low Cardiovascular Risk; A Double-Blind, Randomized, Placebo-Controlled Trial.
[So] Source:Int J Mol Sci;18(2), 2017 02 07.
[Is] ISSN:1422-0067
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:The aim of this study was to evaluate the efficacy and safety of an anti-hypercholesterolemic agent containing , and monacolin K and KA in a sample of Caucasian patients at low cardiovascular risk according to Framingham score. The primary outcome was to evaluate the effects of this nutraceutical combination on lipid profile; the secondary outcome was to evaluate the effect on some inflammatory markers, in particular high sensitivity C-reactive protein and tumor necrosis factor-α interleukin-6. One hundred and forty-three patients were randomized to placebo or Berberol K, once a day, during the dinner, for 3 months, in a randomized, double-blind, placebo-controlled trial. We recorded a significant reduction of fasting plasma glucose with Berberol K compared to placebo (-12.2%, < 0.05). Moreover, we recorded an increase of fasting plasma insulin with Berberol K both compared to baseline and to placebo (+9.9%, < 0.05). Accordingly, the homeostasis model assessment (HOMA) index obtained after treatment with Berberol K was lower than the one in the placebo group (-2.8%, < 0.05). No variations of lipid profile were observed with placebo, while there was a significant decrease of total cholesterol (-20.5%, < 0.05), triglycerides (-17.7%, < 0.05), and low density lipoprotein (LDL) cholestero (-27.8%, < 0.05) with Berberol K, compared to placebo. There was a decrease of high sensitivity C-reactive protein (-30.8%, < 0.05), and interleukin-6 (-25.0%, < 0.05), with Berberol K compared to placebo. In conclusion, combining different hypocholesterolemic nutraceutical agents such as , and monacolin K and KA could be effective and safe to obtain a reduction of lipid profile and an improvement of inflammatory parameters.
[Mh] Termos MeSH primário: Anticolesterolemiantes/administração & dosagem
Doenças Cardiovasculares/tratamento farmacológico
Lovastatina/administração & dosagem
Extratos Vegetais/administração & dosagem
[Mh] Termos MeSH secundário: Adulto
Berberis/química
Biomarcadores
Glicemia
Doenças Cardiovasculares/metabolismo
Combinação de Medicamentos
Feminino
Seres Humanos
Mediadores da Inflamação/metabolismo
Insulina/metabolismo
Lipídeos/sangue
Masculino
Meia-Idade
Resultado do Tratamento
[Pt] Tipo de publicação:CLINICAL TRIAL; JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Anticholesteremic Agents); 0 (Biomarkers); 0 (Blood Glucose); 0 (Drug Combinations); 0 (Inflammation Mediators); 0 (Insulin); 0 (Lipids); 0 (Plant Extracts); 9LHU78OQFD (Lovastatin)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170428
[Lr] Data última revisão:
170428
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170209
[St] Status:MEDLINE


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[PMID]:28146559
[Au] Autor:Angulo DF; Amarilla LD; Anton AM; Sosa V
[Ad] Endereço:Biología Evolutiva, Instituto de Ecología AC, Xalapa, Veracruz, Mexico.
[Ti] Título:Colonization in North American Arid Lands: The Journey of Agarito (Berberis trifoliolata) Revealed by Multilocus Molecular Data and Packrat Midden Fossil Remains.
[So] Source:PLoS One;12(2):e0168933, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Here we conduct research to understand the evolutionary history of a shrubby species known as Agarito (Berberis trifoliolata), an endemic species to the Chihuahuan Desert. We identify genetic signatures based on plastid DNA and AFLP markers and perform niche modelling and spatial connectivity analyses as well as niche modelling based on records in packrats to elucidate whether orogenic events such as mountain range uplift in the Miocene or the contraction/expansion dynamics of vegetation in response to climate oscillations in the Pliocene/Pleistocene had an effect on evolutionary processes in Agarito. Our results of current niche modelling and palaeomodelling showed that the area currently occupied by Berberis trifoliolata is substantially larger than it was during the Last Interglacial period and the Last Glacial Maximum. Agarito was probably confined to small areas in the Northeastern and gradually expanded its distribution just after the Last Glacial Maximum when the weather in the Chihuahuan Desert and adjacent regions became progressively warmer and drier. The most contracted range was predicted for the Interglacial period. Populations remained in stable areas during the Last Glacial Maximum and expanded at the beginning of the Holocene. Most genetic variation occured in populations from the Sierra Madre Oriental. Two groups of haplotypes were identified: the Mexican Plateau populations and certain Northeastern populations. Haplogroups were spatially connected during the Last Glacial Maximum and separated during interglacial periods. The most important prediction of packrat middens palaeomodelling lies in the Mexican Plateau, a finding congruent with current and past niche modelling predictions for agarito and genetic results. Our results corroborate that these climate changes in the Pliocene/Pleistocene affected the evolutionary history of agarito. The journey of agarito in the Chihuahuan Desert has been dynamic, expanding and contracting its distribution range and currently occupying the largest area in its history.
[Mh] Termos MeSH primário: Berberis/genética
Fósseis
Loci Gênicos
Variação Genética
[Mh] Termos MeSH secundário: Análise do Polimorfismo de Comprimento de Fragmentos Amplificados
Animais
Teorema de Bayes
Berberis/classificação
DNA de Cloroplastos
Clima Desértico
Evolução Molecular
Genética Populacional
Haplótipos
México
Modelos Teóricos
Filogenia
Filogeografia
Plastídeos/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Chloroplast)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170808
[Lr] Data última revisão:
170808
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170202
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0168933


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[PMID]:27888048
[Au] Autor:Malik TA; Kamili AN; Chishti MZ; Ahad S; Tantry MA; Hussain PR; Johri RK
[Ad] Endereço:Centre of Research for Development, University of Kashmir, Srinagar, J&K, India. Electronic address: maliktsf@gmail.com.
[Ti] Título:Breaking the resistance of Escherichia coli: Antimicrobial activity of Berberis lycium Royle.
[So] Source:Microb Pathog;102:12-20, 2017 Jan.
[Is] ISSN:1096-1208
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The antimicrobial activity of root bark of Berberis lycium and its principal component berberine was tested against a panel of microbial strains using agar well diffusion test and further analyzed using micro-broth dilution method. Preliminary analysis, on the basis of zone of Inhibition (ZOI) showed that the methanolic extract of B. lycium was highly effective against Escherichia coli (ZOI 41 ± 1 mm). Among the bacterial strains E. coli was found to be most susceptible and among fungi Candida albicans was the most susceptible for berberine as well as the crude methanolic extract of the plant. Methanolic extract of the plant was more effective for E. coli (MIC 1.7 ± 1.18; MBC 2.4 ± 1.18) than berberine (MIC 3.5 ± 0.57) (p < 0.05), whereas berberine was more effective than crude extracts for C. albicans. In addition, E. coli showed the development of resistant colonies after 72 h when tested with berberine but the development of such colonies was not observed with the methanolic extract of the plant. This could be due to the presence of resistance breaking molecules in the crude methanolic extract of B. lycium. Also the MIC index of crude methanolic extract was 1.39 for E. coli, which showed the mode of action to be bactericidal. HPLC analysis revealed the presence of berberine at highest concentration in methanolic extract of the plant, followed by aqueous extract. Potentiation of this berberine by resistance breaking molecules in the crude extract could be a possible explanation for its strong effectiveness.
[Mh] Termos MeSH primário: Anti-Infecciosos/farmacologia
Berberis/química
Farmacorresistência Bacteriana/efeitos dos fármacos
Escherichia coli/efeitos dos fármacos
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Antibacterianos/farmacologia
Antifúngicos/farmacologia
Cromatografia Líquida de Alta Pressão
Fungos/efeitos dos fármacos
Testes de Sensibilidade Microbiana
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Anti-Infective Agents); 0 (Antifungal Agents); 0 (Plant Extracts)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170406
[Lr] Data última revisão:
170406
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161127
[St] Status:MEDLINE


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[PMID]:27788592
[Au] Autor:Hussain N; Adhikari A; Ahmad MS; Wahab AT; Ali M; Choudhary MI
[Ad] Endereço:a H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences , University of Karachi , Karachi , Pakistan.
[Ti] Título:Two new prenylated flavonoids from the roots of Berberis thunbergii DC.
[So] Source:Nat Prod Res;31(7):785-790, 2017 Apr.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Two new prenylated flavonoids, thunbergiols A (1) and B (2), along with three known compounds, chrysin (3), quercetin (4) and berberine (5) were obtained from the methanolic extract of roots of Berberis thunbergii DC. MS, NMR and other spectroscopic techniques were employed for their structural characterisation.
[Mh] Termos MeSH primário: Berberis/química
Flavonoides/química
[Mh] Termos MeSH secundário: Berberina/química
Berberina/isolamento & purificação
Flavonoides/isolamento & purificação
Espectroscopia de Ressonância Magnética
Estrutura Molecular
Extratos Vegetais/química
Raízes de Plantas/química
Prenilação
Quercetina/química
Quercetina/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Flavonoids); 0 (Plant Extracts); 0 (thunbergiol A); 0 (thunbergiol B); 0I8Y3P32UF (Berberine); 3CN01F5ZJ5 (chrysin); 9IKM0I5T1E (Quercetin)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161030
[St] Status:MEDLINE
[do] DOI:10.1080/14786419.2016.1244195


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[PMID]:28375125
[Au] Autor:Asma Ahmed AA; Gulfraz M; Asad MJ; Qureshi R; Bibi S; Shah SI
[Ad] Endereço:Department of biochemistry, Pir Mehr Ali Shah, Arid Agriculture University, Rawalpindi, Pakistan.
[Ti] Título:Hypoglycemic and hypocholesterolemic activity of leave of few medicinal plants against steptozotocin induced hyperglycemia.
[So] Source:Pak J Pharm Sci;29(6):2065-2070, 2016 Nov.
[Is] ISSN:1011-601X
[Cp] País de publicação:Pakistan
[La] Idioma:eng
[Ab] Resumo:Diabetes mellitus (DM) is universal of the hormonal problem and Type II diabetes is foremost obstacle. Accessible management in medicine has numerous contrary paraphernalia. Medical flora shows an essential part in managing diabetes specifically in unindustrialized nations. The present study was done on leaves of Rhazya stricta Decane, Adhatoda zeylanica, Berberis lycium Royle and Olea furrrignea, whose methanolic extracts were used to check their hypoglycemic and hypolipidemic activity by using glucometer and kit method respectively in blood of male and female albino mice Balb C. Results showed that leaves of R. stricta were best for hypoglycemia (125.34±63.79mg/dl, 107.34±18.00mg/dl, 146.00±40.36mg/dl and 178.34±17.03mg/dl), hypocholesterolemia (147.88±21.83mg/dl and 125.89±14.03mg/dl) and triglycerides (103±8.88mg/dl and 89.±43.4mg/dl) in random and fasting conditions, in male and female mice respectively. All plant extract were most effective for hypoglycemia and hypocholesterolemia in female mice as compared to male mice. Moreover statistical analysis revealed that leaves of other plants were also effective but less than leaves of R. stricta. So this plant part and a combination of presently used plants can be used for further studies particularly among females by the purification of active compounds against hyperglycemia and hypercholesterolemia.
[Mh] Termos MeSH primário: Anticolesterolemiantes/farmacologia
Apocynaceae/química
Berberis/química
Glicemia/efeitos dos fármacos
Diabetes Mellitus Experimental/tratamento farmacológico
Hipercolesterolemia/tratamento farmacológico
Hipoglicemiantes/farmacologia
Justicia/química
Olea/química
Extratos Vegetais/farmacologia
Folhas de Planta/química
[Mh] Termos MeSH secundário: Animais
Anticolesterolemiantes/isolamento & purificação
Biomarcadores/sangue
Glicemia/metabolismo
Colesterol/sangue
Diabetes Mellitus Experimental/sangue
Diabetes Mellitus Experimental/induzido quimicamente
Feminino
Hipercolesterolemia/sangue
Hipercolesterolemia/etiologia
Hipoglicemiantes/isolamento & purificação
Masculino
Metanol/química
Camundongos Endogâmicos BALB C
Fitoterapia
Extratos Vegetais/isolamento & purificação
Plantas Medicinais
Solventes/química
Estreptozocina
Triglicerídeos/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anticholesteremic Agents); 0 (Biomarkers); 0 (Blood Glucose); 0 (Hypoglycemic Agents); 0 (Plant Extracts); 0 (Solvents); 0 (Triglycerides); 5W494URQ81 (Streptozocin); 97C5T2UQ7J (Cholesterol); Y4S76JWI15 (Methanol)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171103
[Lr] Data última revisão:
171103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170405
[St] Status:MEDLINE



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