Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.125.374 [Categoria DeCS]
Referências encontradas : 35 [refinar]
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[PMID]:29202306
[Au] Autor:Godevac D; Damjanovic A; Stanojkovic TP; Andelkovic B; Zdunic G
[Ad] Endereço:Institute of Chemistry, Technology and Metallurgy, University of Belgrade, Studentski trg 12-16, 11000 Belgrade, Serbia. Electronic address: dgodjev@chem.bg.ac.rs.
[Ti] Título:Identification of cytotoxic metabolites from Mahonia aquifolium using H NMR-based metabolomics approach.
[So] Source:J Pharm Biomed Anal;150:9-14, 2018 Feb 20.
[Is] ISSN:1873-264X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Herein, we propose a H NMR-based metabolomics method to reveal cytotoxic metabolites from Mahonia aquifolium stem-bark. Primary and secondary metabolites in the Mahonia aquifolium extracts were identified by thorough analysis of H and 2D NMR spectra, without prior isolation. An OPLS multivariate analysis method was used to correlate the chemical composition of the plant extracts with the results of cytotoxic activity against Human cervical adenocarcinoma cell line. Protoberberine alkaloids berberinе and palmatine, along with bisbenzylisoquinoline alkaloid berbamine were identified as the most influential in the OPLS model, with the highest cytotoxic activity.
[Mh] Termos MeSH primário: Mahonia/química
Metabolômica/métodos
Extratos Vegetais/farmacologia
Espectroscopia de Prótons por Ressonância Magnética/métodos
[Mh] Termos MeSH secundário: Adenocarcinoma/tratamento farmacológico
Adenocarcinoma/patologia
Alcaloides/isolamento & purificação
Alcaloides/farmacologia
Antineoplásicos Fitogênicos/química
Antineoplásicos Fitogênicos/isolamento & purificação
Antineoplásicos Fitogênicos/farmacologia
Feminino
Células HeLa
Seres Humanos
Casca de Planta
Extratos Vegetais/química
Neoplasias do Colo do Útero/tratamento farmacológico
Neoplasias do Colo do Útero/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alkaloids); 0 (Antineoplastic Agents, Phytogenic); 0 (Plant Extracts)
[Em] Mês de entrada:1801
[Cu] Atualização por classe:180130
[Lr] Data última revisão:
180130
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171205
[St] Status:MEDLINE


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[PMID]:27175745
[Au] Autor:Ma WK; Li H; Dong CL; He X; Guo CR; Zhang CF; Yu CH; Wang CZ; Yuan CS
[Ad] Endereço:Teaching and Research Section of Traditional Chinese Pharmaceutics, China Pharmaceutical University, Nanjing, Jiangsu 210009, P.R. China.
[Ti] Título:Palmatine from Mahonia bealei attenuates gut tumorigenesis in ApcMin/+ mice via inhibition of inflammatory cytokines.
[So] Source:Mol Med Rep;14(1):491-8, 2016 Jul.
[Is] ISSN:1791-3004
[Cp] País de publicação:Greece
[La] Idioma:eng
[Ab] Resumo:Mahonia bealei is a Chinese folk medicine used to treat various ailments, in particular gastrointestinal inflammation­related illnesses, and palmatine is one of its active constituents. In this study, ApcMin/+ mice, a genetically engineered model, were used to investigate the effects of palmatine on the initiation and progression of gut inflammation and tumorigenesis enhanced by a high­fat diet. The in vitro antiproliferation and anti­inflammation effects of palmatine were evaluated on HT­29 and SW­480 human colorectal cancer cell lines. The concentration­related antiproliferative effects of palmatine on both cell lines (P<0.01) were observed. Palmatine significantly inhibited lipopolysaccharide­induced increase in cytokine interleukin (IL)­8 levels in the HT­29 cells (P<0.01). In the in vivo studies with ApcMin/+ mice, after 10 or 20 mg/kg/day oral palmatine treatment, tumor numbers were significantly reduced in the small intestine and colon in a dose­dependent manner (P<0.01 compared with the model group). The results were supported by tumor distribution data, body weight changes and organ index. The effect on survival was also dose­dependent. Both the low­ and high­dose palmatine treatments significantly increased the life span of the mice (P<0.01). The gut histology from the model group showed a prominent adenomatous change along with inflammatory lesions. With palmatine treatment, however, the dysplastic changes were greatly reduced in the small intestine and colon tissue. Reverse transcription­quantitative polymerase chain reaction analysis of interleukin (IL)­1α, IL1­ß, IL­8, granulocyte­colony stimulating factor and granulocyte macrophage colony­stimulating factor in the gut tissue showed that these inflammatory cytokines were reduced significantly following treatment (all P<0.01); serum cytokine levels were also decreased. Data suggests that palmatine has a clinical value in colorectal cancer therapeutics, and this action is likely linked to the inhibition of inflammatory cytokines.
[Mh] Termos MeSH primário: Proteína da Polipose Adenomatosa do Colo/genética
Alcaloides de Berberina/farmacologia
Citocinas/metabolismo
Neoplasias Gastrointestinais/etiologia
Neoplasias Gastrointestinais/metabolismo
Mediadores da Inflamação/metabolismo
Mahonia/química
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Proteína da Polipose Adenomatosa do Colo/sangue
Animais
Alcaloides de Berberina/química
Linhagem Celular Tumoral
Proliferação Celular/efeitos dos fármacos
Citocinas/sangue
Modelos Animais de Doenças
Neoplasias Gastrointestinais/tratamento farmacológico
Neoplasias Gastrointestinais/patologia
Masculino
Camundongos
Camundongos Knockout
Extratos Vegetais/química
Carga Tumoral
Ensaios Antitumorais Modelo de Xenoenxerto
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Adenomatous Polyposis Coli Protein); 0 (Berberine Alkaloids); 0 (Cytokines); 0 (Inflammation Mediators); 0 (Plant Extracts); G50C034217 (palmatine)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170406
[Lr] Data última revisão:
170406
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160514
[St] Status:MEDLINE
[do] DOI:10.3892/mmr.2016.5285


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[PMID]:27167461
[Au] Autor:Hu W; Wu L; Qiang Q; Ji L; Wang X; Luo H; Wu H; Jiang Y; Wang G; Shen T
[Ad] Endereço:Jiangsu Collaborative Innovation Center of Regional Modern Agriculture & Environmental protection/Jiangsu Key Laboratory for Eco-Agricultural Biotechnology around Hongze Lake, Huaiyin Normal University, Huaian 223300, China.
[Ti] Título:The dichloromethane fraction from Mahonia bealei (Fort.) Carr. leaves exerts an anti-inflammatory effect both in vitro and in vivo.
[So] Source:J Ethnopharmacol;188:134-43, 2016 Jul 21.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:ETHNOPHARMACOLOGICAL RELEVANCE: Mahonia bealei has a long history of medical use in traditional Chinese medicine for the treatment of inflammatory-associated diseases. Despite numerous phytochemical and pharmacological studies, there is a lack of systematic studies to understand the cellular and molecular mechanisms of the anti-inflammatory activity of this plant. AIM OF STUDY: This study aimed to evaluate the anti-inflammatory activity of the dichloromethane fraction from M. bealei leaves (MBL-CH). MATERIALS AND METHODS: RAW 264.7 cells were pretreated with different concentrations of MBL-CH for 30min prior to treatment with 1µg/ml of lipopolysaccharide (LPS). The nuclear factor κB (NF-κB) pathway and subsequent production of inflammatory mediators, such as nitric oxide (NO), prostaglandin E2 (PGE2), and tumour necrosis factor (TNF)-α were investigated. Furthermore, the in vivo mouse model of LPS-induced acute lung injury (ALI) was employed to study the anti-inflammatory effects of MBL-CH. RESULTS: Pre-treatment with MBL-CH significantly inhibited the LPS-stimulated secretion of NO, PGE2, and TNF-α into the culture medium, as well as the mRNA levels of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and TNF-α, which were associated with a reduction in the phosphorylation of IκBα, Akt, and PI3K and inhibition of the transcriptional activity of NF-κB. Furthermore, in vivo experiments revealed that MBL-CH attenuated LPS-stimulated lung inflammation in mice. CONCLUSION: Taken together, our findings indicate that MBL-CH attenuates LPS-stimulated inflammatory responses in macrophages by blocking NF-κB activation through interference with activation of the PI3K/Akt pathway, providing scientific evidence that the plant can be employed in traditional remedies.
[Mh] Termos MeSH primário: Anti-Inflamatórios/farmacologia
Pulmão/efeitos dos fármacos
Macrófagos Peritoneais/efeitos dos fármacos
Mahonia/química
Cloreto de Metileno/química
Extratos Vegetais/farmacologia
Folhas de Planta/química
Pneumonia/prevenção & controle
Solventes/química
[Mh] Termos MeSH secundário: Animais
Anti-Inflamatórios/isolamento & purificação
Citocinas/metabolismo
Modelos Animais de Doenças
Relação Dose-Resposta a Droga
Mediadores da Inflamação/metabolismo
Lipopolissacarídeos/farmacologia
Pulmão/imunologia
Pulmão/metabolismo
Ativação de Macrófagos/efeitos dos fármacos
Macrófagos Peritoneais/imunologia
Macrófagos Peritoneais/metabolismo
Masculino
Camundongos
Camundongos Endogâmicos C57BL
NF-kappa B/metabolismo
Fosfatidilinositol 3-Quinase/metabolismo
Fitoterapia
Extratos Vegetais/isolamento & purificação
Plantas Medicinais
Pneumonia/induzido quimicamente
Pneumonia/imunologia
Pneumonia/metabolismo
Proteínas Proto-Oncogênicas c-akt/metabolismo
Células RAW 264.7
Transdução de Sinais/efeitos dos fármacos
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Cytokines); 0 (Inflammation Mediators); 0 (Lipopolysaccharides); 0 (NF-kappa B); 0 (Plant Extracts); 0 (Solvents); 588X2YUY0A (Methylene Chloride); EC 2.7.1.137 (Phosphatidylinositol 3-Kinase); EC 2.7.11.1 (Proto-Oncogene Proteins c-akt)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170421
[Lr] Data última revisão:
170421
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160512
[St] Status:MEDLINE


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[PMID]:26691316
[Au] Autor:Huang J; Su T; Lebereton-Anberrée J; Zhang ST; Zhou ZK
[Ad] Endereço:Key Laboratory of Tropical Forest Ecology, Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences, Menglun, Yunnan, 666303, China.
[Ti] Título:The oldest Mahonia (Berberidaceae) fossil from East Asia and its biogeographic implications.
[So] Source:J Plant Res;129(2):209-23, 2016 Mar.
[Is] ISSN:1618-0860
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Interpretation of the biogeography of the genus Mahonia (Berberidaceae) is limited by the lack of fossil records in East Asia. Compressed fossil foliage, described here as Mahonia mioasiatica sp. nov., were collected from the Upper Miocene Xiaolongtan Formation in Wenshan, Yunnan, southwest China. These specimens represent the oldest reliable fossil record of Mahonia in East Asia. This new fossil species shows a general similarity to Group Orientales and is most similar to the extant eastern Asian Mahonia conferta. Considering other fossil evidence of Mahonia, we propose a migration route of this genus to Asia over the North Atlantic Land Bridge rather than the Bering Land Bridge. Our results also suggest that North America, Europe and East Asia have been successive centers of diversity for the genus, as a consequence of diversification in Group Orientales potentially related to historical climate change.
[Mh] Termos MeSH primário: Mahonia/anatomia & histologia
[Mh] Termos MeSH secundário: China
Mudança Climática
Fósseis
Geografia
Mahonia/genética
Filogeografia
Dispersão Vegetal
Folhas de Planta/anatomia & histologia
Folhas de Planta/genética
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1612
[Cu] Atualização por classe:171014
[Lr] Data última revisão:
171014
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151223
[St] Status:MEDLINE
[do] DOI:10.1007/s10265-015-0775-y


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[PMID]:26387740
[Au] Autor:He JM; Mu Q
[Ad] Endereço:School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 201203, China.
[Ti] Título:The medicinal uses of the genus Mahonia in traditional Chinese medicine: An ethnopharmacological, phytochemical and pharmacological review.
[So] Source:J Ethnopharmacol;175:668-83, 2015 Dec 04.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:ETHNOPHARMACOLOGICAL RELEVANCE: Plants of the genus Mahonia Nuttall (Berberidaceae) have a long history of medical use in Traditional Chinese Medicine (TCM) for the treatment of a wide range of health disorders, such as tuberculosis, periodontitis, dysentery, pharyngolaryngitis, eczema, and wounds. In the theory of TCM, most Mahonia species exert the effects of relieving internal heat, eliminating dampness, removing toxins, suppressing pain, promoting blood circulation, inhibiting cough and alleviating inflammation. The aim of the review is to provide comprehensive summary on ethnopharmacology, phytochemistry, pharmacology, toxicology and clinical trials of Mahonia species used in TCM based on scientific literature. Available scientific evidence supporting the therapeutic effects of Mahonia species in TCM is demonstrated and opportunities for future research are discussed to highlight the scientific gaps in our knowledge that deserves further investigation. METHODS: The available information on the ethnopharmacological uses in Chinese medicine, phytochemistry, pharmacology and clinical practice of the genus Mahonia was collected from Chinese Herbal Classics, published books, un-published resources, dissertations and various worldwide-accepted scientific databases: CNKI, PubMed, ScienceDirect, SpringerLink, Google Scholar, Wiley, TPL (www.theplantlist.org), SciFinder, and Embase. RESULTS: A variety of ethnomedical usages of Mahonia have been recorded in ancient Chinese books and references. The phytochemical research of this genus has resulted in the identification of more than 150 chemical constituents, among which alkaloids are predominant. The isolated compounds and crude extracts have been shown to exhibit a wide spectrum of in vitro and in vivo pharmacological effects, including antimicrobial, anti-inflammatory, hepatoprotective, antioxidant, antimutagenic and analgesic properties. Preparations containing Mahonia species have been demonstrated to exert good efficacy for the clinical treatment of dysentery, internal and external hemorrhage, acne vulgaris and chronic pharyngitis, among other diseases. CONCLUSIONS: The available scientific references demonstrate that the traditional medical uses of some important Mahonia species in TCM have been evaluated in modern pharmacological studies. Isoquinoline alkaloids may contribute to some of the activities shown by the plants of this genus. However, further studies employing scientific technologies and methods are warranted to reveal the phytochemistry of this genus, particularly to detail the active compounds and the underlying mechanisms.
[Mh] Termos MeSH primário: Mahonia
Medicina Tradicional Chinesa
[Mh] Termos MeSH secundário: Etnofarmacologia
Seres Humanos
Mahonia/química
Mahonia/toxicidade
Compostos Fitoquímicos/análise
Fitoterapia
Preparações de Plantas/química
Preparações de Plantas/farmacologia
Preparações de Plantas/uso terapêutico
Preparações de Plantas/toxicidade
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Phytochemicals); 0 (Plant Preparations)
[Em] Mês de entrada:1610
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150922
[St] Status:MEDLINE


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[PMID]:26298606
[Au] Autor:Wang W; Ma X; Guo X; Zhao M; Tu P; Jiang Y
[Ad] Endereço:State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, China.
[Ti] Título:A series of strategies for solving the shortage of reference standards for multi-components determination of traditional Chinese medicine, Mahoniae Caulis as a case.
[So] Source:J Chromatogr A;1412:100-11, 2015 Sep 18.
[Is] ISSN:1873-3778
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:In order to solve the bottleneck of reference standards shortage for comprehensive quality control of traditional Chinese medicines (TCMs), a series of strategies, including one single reference standard to determine multi-compounds (SSDMC), quantitative analysis by standardized reference extract (QASRE), and quantitative nuclear magnetic resonance spectroscopy (qNMR) were proposed, and Mahoniae Caulis was selected as an example to develop and validate these methods for simultaneous determination of four alkaloids, columbamine, jatrorrhizine, palmatine, and berberine. Comprehensive comparisons among these methods and with the conventional external standard method (ESM) were carried out. The relative expanded uncertainty of measurement was firstly used to compare their credibility. The results showed that all these three new developed methods can accurately accomplish the quantification by using only one purified reference standard, but each of them has its own advantages and disadvantages as well as the specific application scope, which were also discussed in detail in this paper.
[Mh] Termos MeSH primário: Berberina/análise
Medicamentos de Ervas Chinesas/química
Mahonia/química
[Mh] Termos MeSH secundário: Berberina/análogos & derivados
Berberina/normas
Alcaloides de Berberina/análise
Alcaloides de Berberina/normas
Medicamentos de Ervas Chinesas/normas
Espectroscopia de Ressonância Magnética/métodos
Controle de Qualidade
Padrões de Referência
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Berberine Alkaloids); 0 (Drugs, Chinese Herbal); 091S1F8V5Q (jatrorrhizine); 0I8Y3P32UF (Berberine); 7T4808FEJW (columbamine); G50C034217 (palmatine)
[Em] Mês de entrada:1512
[Cu] Atualização por classe:150831
[Lr] Data última revisão:
150831
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150824
[St] Status:MEDLINE


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[PMID]:26186257
[Au] Autor:Li G; Kusari S; Kusari P; Kayser O; Spiteller M
[Ad] Endereço:Institute of Environmental Research (INFU), Department of Chemistry and Chemical Biology, Chair of Environmental Chemistry and Analytical Chemistry, TU Dortmund , Otto-Hahn-Straße 6, D-44221 Dortmund, Germany.
[Ti] Título:Endophytic Diaporthe sp. LG23 Produces a Potent Antibacterial Tetracyclic Triterpenoid.
[So] Source:J Nat Prod;78(8):2128-32, 2015 Aug 28.
[Is] ISSN:1520-6025
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:A new lanostanoid, 19-nor-lanosta-5(10),6,8,24-tetraene-1α,3ß,12ß,22S-tetraol (1), characterized by the presence of an aromatic B ring and hydroxylated at C-1, C-3, C-12, and C-22, was isolated from an endophytic fungus, Diaporthe sp. LG23, inhabiting leaves of the Chinese medicinal plant Mahonia fortunei. Six biosynthetically related known steroids were also isolated in parallel. Their structures were confirmed on the basis of detailed spectroscopic analysis in conjunction with the published data. Compound 1, an unusual fungus-derived 19-nor-lanostane tetracyclic triterpenoid with an aromatic B-ring system, exhibited pronounced antibacterial efficacy against both Gram-positive and -negative bacteria, especially the clinical isolates of Streptococcus pyogenes and Pseudomonas aeruginosa as well as a human pathogenic strain of Staphylococcus aureus. Our results reveal the potential of endophytes not only in conferring host fitness but also in contributing toward traditional host plant medicines.
[Mh] Termos MeSH primário: Antibacterianos/isolamento & purificação
Antibacterianos/farmacologia
Endófitos/química
Lanosterol/isolamento & purificação
Lanosterol/farmacologia
Triterpenos/isolamento & purificação
Triterpenos/farmacologia
[Mh] Termos MeSH secundário: Antibacterianos/química
Seres Humanos
Lanosterol/análogos & derivados
Lanosterol/química
Mahonia/microbiologia
Medicina Tradicional
Testes de Sensibilidade Microbiana
Estrutura Molecular
Folhas de Planta
Plantas Medicinais/química
Plantas Medicinais/microbiologia
Pseudomonas aeruginosa/efeitos dos fármacos
Staphylococcus aureus/efeitos dos fármacos
Streptococcus pyogenes/efeitos dos fármacos
Triterpenos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Triterpenes); 1J05Z83K3M (Lanosterol)
[Em] Mês de entrada:1511
[Cu] Atualização por classe:150828
[Lr] Data última revisão:
150828
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150718
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jnatprod.5b00170


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[PMID]:25917158
[Au] Autor:Zhu W; Hu J; Wang X; Tian J; Komatsu S
[Ad] Endereço:‡National Institute of Crop Science, National Agriculture and Food Research Organization, Tsukuba 305-8518, Japan.
[Ti] Título:Organ-specific analysis of mahonia using gel-free/label-free proteomic technique.
[So] Source:J Proteome Res;14(6):2669-85, 2015 Jun 05.
[Is] ISSN:1535-3907
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Mahonia is an important medicinal plant used for the treatment of human diseases. To explore the molecular mechanisms underlying the different pharmacological functions of Mahonia, organ-specific proteomics was performed. Protein profiles of leaves, stems, and roots from 2-year-old Mahonia plants were determined using gel-free/label-free proteomic technique, and totals of 304, 314, and 182 proteins were identified, respectively, and included 36 common proteins. In leaves, the most abundant proteins related to photosynthesis. Furthermore, polyethylene glycol fractionation was used to identify low-abundance proteins in leaves. With this approach, oxidative pentose phosphate-related proteins were identified in leaves. In stems, the main functional categories of proteins were protein synthesis and redox ascorbate/glutathione metabolism. In roots, proteins were mainly related to protein synthesis, stress, and amino acid metabolism. Of the proteins identified, the abundance of calreticulin was markedly higher in roots than that detected in stems and leaves. Many roots-specific proteins, including S-adenosylmethionine synthetase and (S)-tetrahydroprotoberberine oxidase, involved in the biosynthesis of alkaloids, were identified. Consistent with this finding, levels of the alkaloids, which were columbamine, jatrorrhizine, palmatine, tetrandrine, and berberine, were markedly higher in roots compared to those detected in stems and leaves. Taken together, these results suggest that alkaloid biosynthesis is an important function in Mahonia roots.
[Mh] Termos MeSH primário: Mahonia/metabolismo
Proteínas de Plantas/metabolismo
Estruturas Vegetais/metabolismo
Proteômica
[Mh] Termos MeSH secundário: Alcaloides/metabolismo
Cromatografia Líquida
Eletroforese em Gel de Poliacrilamida
Espectrometria de Massas
Proteínas de Plantas/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Alkaloids); 0 (Plant Proteins)
[Em] Mês de entrada:1603
[Cu] Atualização por classe:150605
[Lr] Data última revisão:
150605
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150429
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jproteome.5b00208


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[PMID]:25172799
[Au] Autor:Zhang SL; Li H; He X; Zhang RQ; Sun YH; Zhang CF; Wang CZ; Yuan CS
[Ad] Endereço:State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, JS 210009, China.
[Ti] Título:Alkaloids from Mahonia bealei posses anti-H⁺/K⁺-ATPase and anti-gastrin effects on pyloric ligation-induced gastric ulcer in rats.
[So] Source:Phytomedicine;21(11):1356-63, 2014 Sep 25.
[Is] ISSN:1618-095X
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:The purpose of this study was to investigate the underlying mechanism(s) of the total alkaloids (TA) from Mahonia bealei in treating pyloric ligation-induced gastric ulcers in rats. Animals were sacrificed after 19 h of the ligation. Gastric acid, peptic activities, mucin levels, H(+)/K(+)-ATPase activities and the gastrin level were analyzed. To improve the accuracy of the observations, IPP 6.0 software was introduced to measure the area of ulcer. TA (18.56 mg/kg/day, i.g.) showed an antiulcer effect by significantly decreasing the gastric ulcer areas (11.28 mm(2)) compared with model group (26.36 mm(2)). The TA ulcer inhibition ratio was 57.2%, compared with the effect of the positive control, omeprazole (62.96%). The results also showed that TA had a significant effect in inhibiting the release of H(+)/K(+)-ATPase, reducing the content of gastrin and decreasing gastric acidity on experimental animals. However, the TA had no significant effects on gastric mucus secretion and pepsin activity. Data indicated that TA had gastric ulcer protective effects by modulating the H(+)/K(+)-ATPase activity and gastrin level. TA has a potential to be developed as a pharmacological agent for the treatment of gastric ulcers.
[Mh] Termos MeSH primário: Alcaloides/farmacologia
Antiulcerosos/farmacologia
Gastrinas/sangue
Mahonia/química
Úlcera Gástrica/tratamento farmacológico
[Mh] Termos MeSH secundário: Animais
Cromatografia Líquida de Alta Pressão
Ácido Gástrico/química
ATPase Trocadora de Hidrogênio-Potássio/metabolismo
Ligadura
Masculino
Mucinas/química
Caules de Planta/química
Ratos Sprague-Dawley
Espectrometria de Massas em Tandem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Alkaloids); 0 (Anti-Ulcer Agents); 0 (Gastrins); 0 (Mucins); EC 3.6.3.10 (H(+)-K(+)-Exchanging ATPase)
[Em] Mês de entrada:1503
[Cu] Atualização por classe:140830
[Lr] Data última revisão:
140830
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140831
[St] Status:MEDLINE


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[PMID]:25053555
[Au] Autor:Sun YH; He X; Yang XL; Dong CL; Zhang CF; Song ZJ; Lu MX; Yang ZL; Li P
[Ad] Endereço:State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China.
[Ti] Título:Absorption characteristics of the total alkaloids from Mahonia bealei in an in situ single-pass intestinal perfusion assay.
[So] Source:Chin J Nat Med;12(7):554-60, 2014 Jul.
[Is] ISSN:1875-5364
[Cp] País de publicação:China
[La] Idioma:eng
[Ab] Resumo:AIM: To investigate the absorption characteristics of the total alkaloids from Mahoniae Caulis (TAMC) through the administration of monterpene absorption enhancers or protein inhibitors. METHOD: The absorption behavior was investigated in an in situ single-pass intestinal perfusion (SPIP) assay in rats. RESULTS: The intestinal absorption of TAMC was much more than that of a single compound or a mixture of compounds (jatrorrhizine, palmatine, and berberine). Promotion of absorption by the bicyclic monoterpenoids (borneol or camphor) was higher than by the monocyclic monoterpenes (menthol or menthone), and promotion by compounds with a hydroxyl group (borneol or menthol) was higher than those with a carbonyl group (camphor or menthone). The apparent permeability coefficient (Papp) of TAMC was increased to 1.8-fold by verapamil, while it was reduced to one half by thiamine. The absorption rate constant (Ka) and Papp of TAMC were unchanged by probenecid and pantoprazole. CONCLUSION: The intestinal absorption characteristics of TAMC might be passive transport, and the intestinum tenue was the best absorptive site. In addition, TAMC might be likely a substrate of P-glycoprotein (P-gp) and organic cation transporters (OCT), rather than multidrug resistance protein (MRP) and breast cancer resistance protein (BCRP). Compared with a single compound and a mixture of compounds, TAMC was able to be absorbed in the blood circulation effectively.
[Mh] Termos MeSH primário: Alcaloides/farmacocinética
Medicamentos de Ervas Chinesas/farmacocinética
Absorção Intestinal
Intestinos/metabolismo
Mahonia/metabolismo
[Mh] Termos MeSH secundário: Alcaloides/química
Animais
Estabilidade de Medicamentos
Medicamentos de Ervas Chinesas/química
Intestinos/química
Cinética
Masculino
Permeabilidade
Ratos
Ratos Sprague-Dawley
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alkaloids); 0 (Drugs, Chinese Herbal)
[Em] Mês de entrada:1503
[Cu] Atualização por classe:140723
[Lr] Data última revisão:
140723
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140724
[St] Status:MEDLINE



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