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Pesquisa : B01.650.940.800.575.912.250.150.210 [Categoria DeCS]
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[PMID]:28726668
[Au] Autor:Gokadze S; Barbakadze V; Mulkijanyan K; Bakuridze A; Bakuridze L
[Ad] Endereço:Tbilisi State Medical University, Georgia.
[Ti] Título:FORMULATION AND TECHNOLOGY DEVELOPMENT OF HERBAL PHENOLIC BIOPOLYMER-CONTAINING FILMS FOR BURN TREATMENT.
[So] Source:Georgian Med News;(267):119-124, 2017 Jun.
[Is] ISSN:1512-0112
[Cp] País de publicação:Georgia (Republic)
[La] Idioma:eng
[Ab] Resumo:Application of phytofilms based on biosolublepolymers is considered as a prospectivemethod for burn treatment . Herbal remedies contain biologically active substances, that are relatively less toxic, do not cause skin irritation or allergic reactions and, importantly, affectstrains of the microorganisms and viruses resistant to antibiotics and synthetic drugs. Nowadays, the advantages are given to such burn healing drugs, which along with high specific efficacy, have analgesic, anti-inflammatory and antimicrobial effects, and don't irritate the tissues. The mentioned peculiarities are characteristic for a new herbal phenolic biopolymer poly[3-(3,4-dihydroxyphenyl) glyceric acid](PDGA), isolated from the roots and stems of different comfrey species . The aim of the study was the development of the formulation and technology of biosoluble films for burn treatment on the basis of PDGA. The optimal content of phytofilm for burn healing was selected on the basis of the biopharmaceutical study results. The impact of the film-former on the quality, adhesion and moisture absorption of the phytofilmhas been studied. The optimal degree of the phytofilm moisture, determining its high adhesive properties,was established. The film prepared on the basis of sodium alginate, with 30.4% humidity, demonstrated the greatest adhesion strength. After investigation of the PDGA release it was found, that the hydrophilic bases such as: sodium carboxymethyl-cellulose (69.2%) andsodium alginate (78,65%) appeared to be optimal among the others. At the same time, taking into consideration the disadvantages of sodium carboxymethyl-cellulose (tautening effect on burnt surface, relatively low stability), a film based on sodium alginate has been chosen. The manufacturing technology for obtaining PDGA-containing phytofilm by casting is proposed. Theshelf-lifeofproposedPDGA-containingphytofilmis 2 years.
[Mh] Termos MeSH primário: Queimaduras/terapia
Confrei/química
Ácidos Glicéricos/química
[Mh] Termos MeSH secundário: Materiais Biocompatíveis/química
Biopolímeros/química
Raízes de Plantas/química
Caules de Planta/química
Cicatrização
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biocompatible Materials); 0 (Biopolymers); 0 (Glyceric Acids); 0 (poly(3-(3,4-dihydroxyphenyl)glyceric acid))
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170919
[Lr] Data última revisão:
170919
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170721
[St] Status:MEDLINE


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[PMID]:28252436
[Au] Autor:Gokadze S; Barbakadze V; Mulkijanyan K; Bakuridze L; Bakuridze A
[Ad] Endereço:Tbilisi State Medical University, Georgia.
[Ti] Título:DEVELOPMENT OF FORMULATION AND TECHNOLOGY FOR THE POLY[3-(3,4-DIHYDROXYPHENYL)GLYCERIC ACID] GEL.
[So] Source:Georgian Med News;(262):92-98, 2017 Jan.
[Is] ISSN:1512-0112
[Cp] País de publicação:Georgia (Republic)
[La] Idioma:eng
[Ab] Resumo:One of the most actual problems of pharmacy is the development of medication forms for external application with complex effects on (gel, emplastro, aerosol, etc.) skin wounds, burns and inflammatory factors. The centuries-old practice of using phyto-preparations (herbal remedies) proved that they have fewer side effects in comparison with synthetic drugs. Despite the wide application of herbal preparations, in the literature there is a little information about their application in development of wound and burn healing modern dosage forms. Among the medicinal plants with the mentioned pharmacological actions, comfrey (Symphytum L.) should be distinguished. Phenolic polymer poly[3-(3,4-dihydroxyphenyl)glyceric acid] (PDGA) or poly[oxy-1-carboxy-2-(3,4-dihydroxyphenyl)ethylene], amounting approximately 25% of polysaccharides and 1.5-2.5% of dry plant material, were isolated from the roots and stems of Caucasian comfrey species (S. asperum, S. caucasicum). Contrary to polysaccharides this phenolic polymer of Comfrey appeared to have a high immunomodulatory (anticomplement), antioxidative, antilipoperoxidantive, anti-inflammatory and wound-healing efficacy/activities. The aim of the study was development of the composition and technology of PDGA-containing gel. According to the results of complex biopharmaceutical studies PDGA gel optimal composition has been proved. The technological scheme for preparation of PDGA gel has been developed. PDGA gel stability under normal conditions of storage at +40С was studied. The gel has a shelf life (determined expiration date) of 2 year.
[Mh] Termos MeSH primário: Ácidos Glicéricos/química
[Mh] Termos MeSH secundário: Confrei/química
Liberação Controlada de Fármacos
Excipientes
Géis
Ácidos Glicéricos/isolamento & purificação
Osmose
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Excipients); 0 (Gels); 0 (Glyceric Acids); 0 (poly(3-(3,4-dihydroxyphenyl)glyceric acid))
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170410
[Lr] Data última revisão:
170410
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170303
[St] Status:MEDLINE


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[PMID]:27840092
[Au] Autor:Jedlinszki N; Balázs B; Csányi E; Csupor D
[Ad] Endereço:University of Szeged, Faculty of Pharmacy, Department of Pharmacognosy, H-6720, Szeged, Eötvös Street 6, Hungary.
[Ti] Título:Penetration of lycopsamine from a comfrey ointment through human epidermis.
[So] Source:Regul Toxicol Pharmacol;83:1-4, 2017 Feb.
[Is] ISSN:1096-0295
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Mutagenic and teratogenic pyrrolizidine alkaloids (PAs) have been identified in several plant species. The industrially most important PA-containing plant is Symphytum officinale (common comfrey). The application of its root is restricted in several countries due to its PA content. In medicines, the daily alkaloid quantity and duration of treatment may be limited even in case of topical application. Due to the confirmed good absorption of PAs from the gastrointestinal tract, the prohibition of oral use is justified, however the limitation of external application is not supported by relevant data. Penetration experiments on human skin are not available to be a rational basis for limitation. The aim of our work was to carry out pharmacokinetic studies on the diffusion and penetration of lycopsamine (a main PA of comfrey) from a Symphytum product through a synthetic membrane and human skin. Investigations were carried out on vertical Franz diffusion cell and lycopsamine was quantified by a validated LC-MS method. The amount of lycopsamine diffused through a synthetic membrane varied between 0.11% and 0.72% (within 24 h). On human epidermis, the rate of penetration was lower (0.04-0.22%). Our results may contribute to the more realistic toxicological assessment of externally applied PA-containing products.
[Mh] Termos MeSH primário: Confrei/química
Epiderme/metabolismo
Extratos Vegetais/metabolismo
Alcaloides de Pirrolizidina/metabolismo
Absorção Cutânea
[Mh] Termos MeSH secundário: Administração Cutânea
Adulto
Cromatografia Líquida de Alta Pressão
Difusão
Seres Humanos
Cinética
Masculino
Membranas Artificiais
Modelos Biológicos
Pomadas
Fitoterapia
Extratos Vegetais/administração & dosagem
Extratos Vegetais/isolamento & purificação
Extratos Vegetais/toxicidade
Raízes de Plantas
Plantas Medicinais
Alcaloides de Pirrolizidina/administração & dosagem
Alcaloides de Pirrolizidina/isolamento & purificação
Alcaloides de Pirrolizidina/toxicidade
Medição de Risco
Espectrometria de Massas por Ionização por Electrospray
Espectrometria de Massas em Tandem
Toxicocinética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Membranes, Artificial); 0 (Ointments); 0 (Plant Extracts); 0 (Pyrrolizidine Alkaloids); T82SFG1584 (indicine)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161115
[St] Status:MEDLINE


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[PMID]:27908913
[Au] Autor:Vithayathil MK; Edwards M
[Ad] Endereço:Department of Accident and Emergency, King's College Hospital, London, UK.
[Ti] Título:Comfrey herbal remedy causing second-degree heart block: do not be outfoxed by digitalis.
[So] Source:BMJ Case Rep;2016, 2016 Dec 01.
[Is] ISSN:1757-790X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A previously well woman aged 63 years presents to the emergency department with vomiting, palpitations and 3 presyncopal episodes. She had no previous medical or cardiac history, with the patient stating that she tried a herbal remedy of boiled comfrey leaves for insomnia 18 hours before arrival to the department. Her ECG showed multiple abnormalities, including bradycardia, second-degree atrioventricular node block, Mobitz Type 2, a shortened QT interval, downsloping ST depression and presence of U waves. After viewing the images of comfrey and foxglove, it highlighted the possibility of mistaken ingestion of Digitalis, containing the organic forms of cardiac glycosides, such as digoxin and digitoxin. Raised serum digoxin levels confirmed this. The patient was haemodynamically stable, and given digoxin-binding antibodies. After 5 days of cardiac monitoring, her ECG returned to normal rhythm, and she was discharged home.
[Mh] Termos MeSH primário: Acidentes
Anticorpos Heterófilos/uso terapêutico
Bloqueio Atrioventricular/induzido quimicamente
Confrei
Digitalis/envenenamento
Digoxina/envenenamento
Intoxicação por Plantas/diagnóstico
Distúrbios do Início e da Manutenção do Sono/tratamento farmacológico
[Mh] Termos MeSH secundário: Anticorpos Heterófilos/imunologia
Bradicardia/etiologia
Digitalis/imunologia
Digoxina/imunologia
Eletrocardiografia
Feminino
Seres Humanos
Meia-Idade
Folhas de Planta/envenenamento
Intoxicação por Plantas/complicações
Intoxicação por Plantas/tratamento farmacológico
Plantas Medicinais
Resultado do Tratamento
Vômito/etiologia
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antibodies, Heterophile); 73K4184T59 (Digoxin)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170512
[Lr] Data última revisão:
170512
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161203
[St] Status:MEDLINE


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[PMID]:26828003
[Au] Autor:Canello S; Gasparini G; Luisetto P; Di Cerbo A; Pomerri F
[Ad] Endereço:Homeopathic Medical School, Verona, Italy. Electronic address: Sergio.canello.5@facebook.com.
[Ti] Título:Bone computed tomography mineral content evaluation in chickens: effects of substances in homeopathic concentration.
[So] Source:Homeopathy;105(1):92-5, 2016 Feb.
[Is] ISSN:1476-4245
[Cp] País de publicação:Scotland
[La] Idioma:eng
[Ab] Resumo:METHODS: Ninety-six cobb race chickens were equally divided in 4 groups and randomly assigned to receive a standard treatment feed + homeopathic concentrations of Symphytum (S.) officinalis (9CH), or standard treatment feed + homeopathic concentrations of Tricalcarea (4CH), or standard treatment feed + homeopathic concentrations of Calcarea (C.) carbonica (30CH) or a placebo (the same feed but without any homeopathic compound) in order to assess the ability of the homeopathic compounds to increase the concentration of calcium hydroxyapatite in the sternal spongy bone tissue. We measured the concentration of calcium hydroxyapatite in the sternal spongy bone tissue of all chickens by means of a computed tomography (CT). RESULTS: 30%, 36% and 63% increase of sternum spongy-bone mineralization was observed after a 2 years period in the treatment groups with S. officinalis (9CH), Tricalcarea (4CH) (*P < 0.05) and C. carbonica (30CH) (***P < 0.001) respectively. CONCLUSION: Bone mineralization is usually low in battery chickens reared in commercial poultry-sheds, creating a weakness of the whole animal supporting apparatus. Homeopathic preparations with bone-tissue tropism may improve their health quality.
[Mh] Termos MeSH primário: Densidade Óssea/efeitos dos fármacos
Homeopatia/métodos
Tomografia Computadorizada por Raios X/métodos
Tomografia Computadorizada por Raios X/veterinária
[Mh] Termos MeSH secundário: Ração Animal/efeitos adversos
Animais
Galinhas
Confrei
Durapatita/análise
Minerais/uso terapêutico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Minerals); 91D9GV0Z28 (Durapatite)
[Em] Mês de entrada:1609
[Cu] Atualização por classe:160201
[Lr] Data última revisão:
160201
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160202
[St] Status:MEDLINE


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[PMID]:26177929
[Au] Autor:Brown AW; Stegelmeier BL; Colegate SM; Gardner DR; Panter KE; Knoppel EL; Hall JO
[Ad] Endereço:USDA/ARS Poisonous Plant Research Laboratory, Logan, UT, 84341, USA.
[Ti] Título:The comparative toxicity of a reduced, crude comfrey (Symphytum officinale) alkaloid extract and the pure, comfrey-derived pyrrolizidine alkaloids, lycopsamine and intermedine in chicks (Gallus gallus domesticus).
[So] Source:J Appl Toxicol;36(5):716-25, 2016 May.
[Is] ISSN:1099-1263
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Comfrey (Symphytum officinale), a commonly used herb, contains dehydropyrrolizidine alkaloids that, as a group of bioactive metabolites, are potentially hepatotoxic, pneumotoxic, genotoxic and carcinogenic. Consequently, regulatory agencies and international health organizations have recommended comfrey be used for external use only. However, in many locations comfrey continues to be ingested as a tisane or as a leafy vegetable. The objective of this work was to compare the toxicity of a crude, reduced comfrey alkaloid extract to purified lycopsamine and intermedine that are major constituents of S. officinale. Male, California White chicks were orally exposed to daily doses of 0.04, 0.13, 0.26, 0.52 and 1.04 mmol lycopsamine, intermedine or reduced comfrey extract per kg bodyweight (BW) for 10 days. After another 7 days chicks were euthanized. Based on clinical signs of poisoning, serum biochemistry, and histopathological analysis the reduced comfrey extract was more toxic than lycopsamine and intermedine. This work suggests a greater than additive effect of the individual alkaloids and/or a more potent toxicity of the acetylated derivatives in the reduced comfrey extract. It also suggests that safety recommendations based on purified compounds may underestimate the potential toxicity of comfrey.
[Mh] Termos MeSH primário: Confrei/toxicidade
Extratos Vegetais/toxicidade
Alcaloides de Pirrolizidina/toxicidade
[Mh] Termos MeSH secundário: Animais
Aspartato Aminotransferases/sangue
Ácidos e Sais Biliares/sangue
Galinhas
Colesterol/sangue
Confrei/química
Creatina Quinase/sangue
L-Iditol 2-Desidrogenase/sangue
L-Lactato Desidrogenase/sangue
Fígado/efeitos dos fármacos
Fígado/metabolismo
Masculino
Alcaloides de Pirrolizidina/química
Triglicerídeos/sangue
gama-Glutamiltransferase/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Nm] Nome de substância:
0 (Bile Acids and Salts); 0 (Plant Extracts); 0 (Pyrrolizidine Alkaloids); 0 (Triglycerides); 0 (intermedine); 97C5T2UQ7J (Cholesterol); EC 1.1.1.14 (L-Iditol 2-Dehydrogenase); EC 1.1.1.27 (L-Lactate Dehydrogenase); EC 2.3.2.2 (gamma-Glutamyltransferase); EC 2.6.1.1 (Aspartate Aminotransferases); EC 2.7.3.2 (Creatine Kinase); T82SFG1584 (indicine)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150717
[St] Status:MEDLINE
[do] DOI:10.1002/jat.3205


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[PMID]:26482059
[Au] Autor:Mudge EM; Jones AM; Brown PN
[Ad] Endereço:a Department of Applied Research , BC Institute of Technology , Burnaby , BC , Canada.
[Ti] Título:Quantification of pyrrolizidine alkaloids in North American plants and honey by LC-MS: single laboratory validation.
[So] Source:Food Addit Contam Part A Chem Anal Control Expo Risk Assess;32(12):2068-74, 2015.
[Is] ISSN:1944-0057
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Pyrrolizidine alkaloids (PAs) are a class of naturally occurring compounds produced by many flowering plants around the World. Their presence as contaminants in food systems has become a significant concern in recent years. For example, PAs are often found as contaminants in honey through pollen transfer. A validated method was developed for the quantification of four pyrrolizidine alkaloids and one pyrrolizidine alkaloid N-oxide in plants and honey grown and produced in British Columbia. The method was optimised for extraction efficiency from the plant materials and then subjected to a single-laboratory validation to assess repeatability, accuracy, selectivity, LOD, LOQ and method linearity. The PA content in plants ranged from1.0 to 307.8 µg/g with repeatability precision between 3.8 and 20.8% RSD. HorRat values were within acceptable limits and ranged from 0.62 to 1.63 for plant material and 0.56-1.82 for honey samples. Method accuracy was determined through spike studies with recoveries ranging from 84.6 to 108.2% from the raw material negative control and from 82.1-106.0 % for the pyrrolizidine alkaloids in corn syrup. Based on the findings in this single-laboratory validation, this method is suitable for the quantitation of lycopsamine, senecionine, senecionine N-oxide, heliosupine and echimidine in common comfrey (Symphytum officinale), tansy ragwort (Senecio jacobaea), blueweed (Echium vulgare) and hound's tongue (Cynoglossum officinale) and for PA quantitation in honey and found that PA contaminants were present at low levels in BC honey.
[Mh] Termos MeSH primário: Poluentes Ambientais/isolamento & purificação
Mel/análise
Extratos Vegetais/química
Alcaloides de Pirrolizidina/isolamento & purificação
[Mh] Termos MeSH secundário: Boraginaceae/química
Colúmbia Britânica
Calibragem
Cromatografia Líquida
Confrei/química
Echium/química
Contaminação de Alimentos/análise
Xarope de Milho Rico em Frutose/química
Seres Humanos
Limite de Detecção
Reprodutibilidade dos Testes
Senécio/química
Espectrometria de Massas em Tandem
Zea mays/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; VALIDATION STUDIES
[Nm] Nome de substância:
0 (Environmental Pollutants); 0 (High Fructose Corn Syrup); 0 (Plant Extracts); 0 (Pyrrolizidine Alkaloids); 13268-67-2 (senecionine N-oxide); BO6N1U5YG6 (senecionine); T82SFG1584 (indicine)
[Em] Mês de entrada:1609
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151021
[St] Status:MEDLINE
[do] DOI:10.1080/19440049.2015.1099743


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[PMID]:26411005
[Au] Autor:Jedlinszki N; Csupor D
[Ti] Título:A Validated, Rapid HPLC-ESI-MS/MS Method for the Determination of Lycopsamine.
[So] Source:Nat Prod Commun;10(7):1181-2, 2015 Jul.
[Is] ISSN:1934-578X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The aim of the present work was to develop and validate an HPLC-MS/MS method for the determination of a major pyrrolizidine alkaloid of comfrey (lycopsamine) in aqueous samples as a basis for the development of a method for the determination of absorption of lycopsamine by human skin. A linear calibration curve was established in the range of 1.32-440 ng. The intraday precision during the 3-day validation period ranged between 0.57 and 2.48% while the interday precision was 1.70% and 1.95% for quality control samples. LOD was 0.014 ng and recovery was above 97%. The lycopsamine content of the samples stored for 9 and 25 days at 22 degrees C, 10 degrees C and -25 degrees C did not vary. These results underline the good repeatability and accuracy of our method and allow the analysis of samples with very low lycopsamine content.
[Mh] Termos MeSH primário: Confrei/química
Alcaloides de Pirrolizidina/análise
Espectrometria de Massas por Ionização por Electrospray/métodos
[Mh] Termos MeSH secundário: Ácido Acético
Cromatografia Líquida de Alta Pressão
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; VALIDATION STUDIES
[Nm] Nome de substância:
0 (Pyrrolizidine Alkaloids); Q40Q9N063P (Acetic Acid); T82SFG1584 (indicine)
[Em] Mês de entrada:1511
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150929
[St] Status:MEDLINE


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[PMID]:25880800
[Au] Autor:Savic VLj; Nikolic VD; Arsic IA; Stanojevic LP; Najman SJ; Stojanovic S; Mladenovic-Ranisavljevic II
[Ad] Endereço:University of Nis, Department for Pharmacy, Faculty of Medicine, Blvd. Dr Zoran Djindjic 81, 18000 Nis, Serbia.
[Ti] Título:Comparative Study of the Biological Activity of Allantoin and Aqueous Extract of the Comfrey Root.
[So] Source:Phytother Res;29(8):1117-22, 2015 Aug.
[Is] ISSN:1099-1573
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:This study investigates the biological activity of pure allantoin (PA) and aqueous extract of the comfrey (Symphytum officinale L.) root (AECR) standardized to the allantoin content. Cell viability and proliferation of epithelial (MDCK) and fibroblastic (L929) cell line were studied by using MTT test. Anti-irritant potential was determined by measuring electrical capacitance, erythema index (EI) and transepidermal water loss of artificially irritated skin of young healthy volunteers, 3 and 7 days after application of creams and gels with PA or AECR. Pure allantoin showed mild inhibitory effect on proliferation of both cell lines at concentrations 40 and 100 µg/ml, but more pronounced on MDCK cells. Aqueous extract of the comfrey root effect on cell proliferation in concentrations higher than 40 µg/ml was significantly stimulatory for L929 but inhibitory for MDCK cells. Pharmaceutical preparations that contained AECR showed better anti-irritant potential compared with PA. Creams showed better effect on hydration and EI compared with the gels that contained the same components. Our results indicate that the biological activity of the comfrey root extract cannot be attributed only to allantoin but is also likely the result of the interaction of different compounds present in AECR. Topical preparations that contain comfrey extract may have a great application in the treatment of skin irritation.
[Mh] Termos MeSH primário: Alantoína/farmacologia
Confrei/química
Eritema/tratamento farmacológico
Extratos Vegetais/farmacologia
Raízes de Plantas/química
Pele/efeitos dos fármacos
[Mh] Termos MeSH secundário: Administração Cutânea
Animais
Linhagem Celular
Proliferação Celular/efeitos dos fármacos
Sobrevivência Celular/efeitos dos fármacos
Cães
Géis
Seres Humanos
Células Madin Darby de Rim Canino
Camundongos
Extratos Vegetais/administração & dosagem
Creme para a Pele
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Gels); 0 (Plant Extracts); 344S277G0Z (Allantoin)
[Em] Mês de entrada:1512
[Cu] Atualização por classe:150807
[Lr] Data última revisão:
150807
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150417
[St] Status:MEDLINE
[do] DOI:10.1002/ptr.5356


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[PMID]:25531790
[Au] Autor:Janes D; Kreft S
[Ti] Título:TLC densitometric method for screening of lycopsamine in comfrey root (Symphytum officinale L.) extracts using retrorsine as a reference compound.
[So] Source:Acta Pharm;64(4):503-8, 2014 Dec.
[Is] ISSN:1846-9558
[Cp] País de publicação:Croatia
[La] Idioma:eng
[Ab] Resumo:Due to severe toxicity of pyrrolizidine alkaloids, their quantification in medicinal products is very important. The idea of this research was to use retrorsine as a surrogate reference compound instead of lycopsamine reference or lycopsamine isolated from comfrey. A method for the analysis of lycopsamine in extracts of comfrey roots was developed and validated, employing thin layer chromatography, derivatisation with Dann-Mattocks reagent followed by densitometric analysis. The new method showed linearity within 0.70 to 7.0 µg of lycopsamine per application of 10 µL of a solution. It has also been proven to be specific and precise (repeatability RSD 2-4 % within the plate). The method was successfully employed for quantification of lycopsamine in comfrey root and comfrey root medicinal products such as ointments.
[Mh] Termos MeSH primário: Cromatografia em Camada Delgada/métodos
Confrei/química
Densitometria/métodos
Alcaloides de Pirrolizidina/análise
[Mh] Termos MeSH secundário: Extratos Vegetais/análise
Extratos Vegetais/química
Raízes de Plantas
Alcaloides de Pirrolizidina/química
Alcaloides de Pirrolizidina/isolamento & purificação
Padrões de Referência
[Pt] Tipo de publicação:JOURNAL ARTICLE; VALIDATION STUDIES
[Nm] Nome de substância:
0 (Plant Extracts); 0 (Pyrrolizidine Alkaloids); T82SFG1584 (indicine); XJ86XWL8IY (retrorsine)
[Em] Mês de entrada:1507
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141223
[St] Status:MEDLINE



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