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Pesquisa : B01.650.940.800.575.912.250.150.327 [Categoria DeCS]
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[PMID]:27701140
[Au] Autor:Owis AI; Abo-Youssef AM; Osman AH
[Ti] Título:Leaves of Cordia boissieri A. DC. as a potential source of bioactive secondary metabolites for protection against metabolic syndrome-induced in rats.
[So] Source:Z Naturforsch C;72(3-4):107-118, 2017 Mar 01.
[Is] ISSN:0939-5075
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Cordia boissieri A. DC. (Boraginaceae) is traditionally used as an herbal remedy for diabetes by Hispanic women in Southwestern USA. A recent investigation showed the significant protective effect of ethyl acetate extract against metabolic syndrome (MS). However, the corresponding active principles responsible for this effect and relations between their structure and biological actions remain unclear. Thus, ethyl acetate extract was subjected to column chromatography, which yielded seven compounds identified on the basis of spectroscopic data as rutin, hesperidin, kaempferol-3-O-ß-d-glucopyranoside, rosmarinic acid, ß-sitosterol-3-O-ß-d-glucopyranoside, quercetin, and kaempferol. The isolated compounds (5 mg/kg/day) were tested in a fructose enriched-diet rat model using metformin as a standard drug. Blood samples were withdrawn for estimation of MS-associated biomarkers and liver samples were subjected to histopathological and immunohistochemical examination. The isolated compounds impaired most of the changes associated with MS as evidenced by improved insulin sensitivity, glucose tolerance, kidney function, lipid profiles and reduced oxidative stress and inflammation by different degrees. It is worth noting that quercetin and kaempferol showed the most potent effect. Structure-activity relationship study revealed that the presence of 2,3-double bond in ring C and ortho-hydroxylation in ring B increases the flavonoids activity while glycosylation or methylation decreased this activity.
[Mh] Termos MeSH primário: Anti-Inflamatórios/farmacologia
Antioxidantes/farmacologia
Cordia/química
Hipoglicemiantes/farmacologia
Quempferóis/farmacologia
Síndrome Metabólica/tratamento farmacológico
Quercetina/farmacologia
[Mh] Termos MeSH secundário: Acetatos/química
Animais
Anti-Inflamatórios/isolamento & purificação
Antioxidantes/isolamento & purificação
Flavonóis/isolamento & purificação
Flavonóis/farmacologia
Alimentos Formulados/efeitos adversos
Frutose/efeitos adversos
Hipoglicemiantes/isolamento & purificação
Quempferóis/isolamento & purificação
Masculino
Síndrome Metabólica/etiologia
Síndrome Metabólica/metabolismo
Síndrome Metabólica/patologia
Estresse Oxidativo/efeitos dos fármacos
Extratos Vegetais/química
Folhas de Planta/química
Quercetina/isolamento & purificação
Ratos
Ratos Wistar
Metabolismo Secundário
Solventes/química
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acetates); 0 (Anti-Inflammatory Agents); 0 (Antioxidants); 0 (Flavonols); 0 (Hypoglycemic Agents); 0 (Kaempferols); 0 (Plant Extracts); 0 (Solvents); 30237-26-4 (Fructose); 731P2LE49E (kaempferol); 76845O8NMZ (ethyl acetate); 9IKM0I5T1E (Quercetin)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161005
[St] Status:MEDLINE


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[PMID]:27706706
[Au] Autor:Brito FA; Nizio DA; Silva AV; Diniz LE; Rabbani AR; Arrigoni-Blank MF; Alvares-Carvalho SV; Figueira GM; Montanari Júnior I; Blank AF
[Ad] Endereço:Laboratório de Recursos Genéticos Vegetais e Óleos Essenciais, Departamento de Engenharia Agronômica, Universidade Federal de Sergipe, São Cristóvão, SE, Brasil.
[Ti] Título:Genetic diversity analysis of Varronia curassavica Jacq. accessions using ISSR markers.
[So] Source:Genet Mol Res;15(3), 2016 Sep 02.
[Is] ISSN:1676-5680
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:Varronia curassavica Jacq. is a medicinal and aromatic plant from Brazil with significant economic importance. Studies on genetic diversity in active germplasm banks (AGB) are essential for conservation and breeding programs. The aim of this study was to analyze the genetic diversity of V. curassavica accessions of the AGB of Medicinal and Aromatic Plants of the Federal University of Sergipe (UFS), using inter-simple sequence repeat molecular markers. Twenty-four primers were tested, and 14 were polymorphic and informative, resulting in 149 bands with 97.98% polymorphism. The UPGMA dendrogram divided the accessions into Clusters I and II. Jaccard similarity coefficients for pair-wise comparisons of accessions ranged between 0.24 and 0.78. The pairs of accessions VCUR-001/VCUR-503, VCUR-001/VCUR-504, and VCUR-104/VCUR-501 showed relatively low similarity (0.24), and the pair of accessions VCUR-402/VCUR- 403 showed medium similarity (0.78). Twenty-eight accessions were divided into three distinct clusters, according to the STRUCTURE analysis. The genetic diversity of V. curassavica in the AGB of UFS is low to medium, and it requires expansion. Accession VCUR-802 is the most suitable for selection in breeding program of this species, since it clearly represents all of the diversity present in the AGB.
[Mh] Termos MeSH primário: Cordia/genética
Repetições de Microssatélites
Filogenia
Polimorfismo Genético
[Mh] Termos MeSH secundário: Análise por Conglomerados
Cordia/classificação
Primers do DNA
Marcadores Genéticos
Melhoramento Vegetal
Plantas Medicinais
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA Primers); 0 (Genetic Markers)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170224
[Lr] Data última revisão:
170224
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161006
[St] Status:MEDLINE
[do] DOI:10.4238/gmr.15038681


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[PMID]:27659390
[Au] Autor:Fouseki MM; Damianakos H; Karikas GA; Roussakis C; P Gupta M; Chinou I
[Ad] Endereço:Division of Pharmacognosy and Chemistry of Natural Products, Department of Pharmacy, University of Athens, 15471 Athens, Greece.
[Ti] Título:Chemical constituents from Cordia alliodora and C. colloccoca (Boraginaceae) and their biological activities.
[So] Source:Fitoterapia;115:9-14, 2016 Dec.
[Is] ISSN:1873-6971
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Two new natural products, 5-O-[ß-D-apiofuranosyl-(1→6)-ß-d-glucopyranosyl]-1-isoindolinone (1) as well as N-(2E)-3-[(2S,3R)-2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-7-methoxy-2,3-dihydro-1-benzofuran-5-yl]acryloylglycine (2), along with four known compounds (3-6), were isolated from the methanolic extract of Cordia alliodora root bark. Furthermore, the methanolic extract of Cordia colloccoca leaves, afforded the known flavonoids afzelin (7) and quercitrin (8). The isolated secondary metabolites were assayed for their antimicrobial activities against a panel of 6g positive and negative bacteria and three human pathogenic fungi. Moreover, their antiproliferative effect was also evaluated in vitro against the human non-small-cell bronchopulmonary carcinoma line NSCLC-N6, the epidermoid lung cancer cell line A549 as well as the normal human skin fibroblast cell line (AG01523).
[Mh] Termos MeSH primário: Cordia/química
Indóis/química
Extratos Vegetais/química
[Mh] Termos MeSH secundário: Bactérias/efeitos dos fármacos
Linhagem Celular Tumoral
Cordia/classificação
Fibroblastos/efeitos dos fármacos
Fungos/efeitos dos fármacos
Seres Humanos
Indóis/isolamento & purificação
Manosídeos/química
Manosídeos/isolamento & purificação
Testes de Sensibilidade Microbiana
Estrutura Molecular
Casca de Planta/química
Folhas de Planta/química
Raízes de Plantas/química
Proantocianidinas/química
Proantocianidinas/isolamento & purificação
Quercetina/análogos & derivados
Quercetina/química
Quercetina/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Indoles); 0 (Mannosides); 0 (Plant Extracts); 0 (Proanthocyanidins); 2Y8906LC5P (quercitrin); 5M86W1YH7O (afzelin); 9IKM0I5T1E (Quercetin)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161107
[St] Status:MEDLINE


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[PMID]:27618564
[Au] Autor:Rahman MA; Akhtar J
[Ad] Endereço:a Bioactive Research Laboratory, Faculty of Pharmacy, Department of Pharmaceutical Chemistry , Integral University , Lucknow , India.
[Ti] Título:A new linoleiyl arabinopyranoside from the bark of Bauhinia racemosa Lam and a new flavonoidal glycoside from the leaves of Cordia dichotoma Linn.
[So] Source:Nat Prod Res;30(20):2265-73, 2016 Oct.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Phytochemical investigation is very valuable for the ethnomedicinally important plants Bauhinia racemosa Lam (BR) and Cordia dichotoma Linn (CD) used for the cure of variety of ailments. This study was thus designed for phytochemical investigation of BR bark and CD leaves. Phytoconstituents were isolated from the methanolic extracts of the plants by column chromatography using silica gel as stationary phase. The structures had been established on the basis of their physicochemical and spectral data, i.e. IR, (1)H NMR, (13)C NMR and MS. Elution of the columns with different solvents furnished six compounds (1-6) from the methanolic extract of BR bark and three compounds (7-9) from the methanolic extract of CD leaves which were structurally elucidated. The present phytochemical investigation reported several new compounds useful in increasing the existing knowledge of phytoconstituents from BR bark and CD leaves which is very valuable, as these drugs are used in the Indian traditional systems of medicine.
[Mh] Termos MeSH primário: Bauhinia/química
Cordia/química
Glicosídeos/isolamento & purificação
[Mh] Termos MeSH secundário: Sequência de Carboidratos
Glicosídeos/análise
Glicosídeos/química
Espectroscopia de Ressonância Magnética
Estrutura Molecular
Casca de Planta/química
Extratos Vegetais/análise
Extratos Vegetais/química
Folhas de Planta/química
Plantas Medicinais/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Glycosides); 0 (Plant Extracts)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160913
[St] Status:MEDLINE
[do] DOI:10.1080/14786419.2016.1163694


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[PMID]:27232056
[Au] Autor:Khan K; Firdous S; Ahmad A; Fayyaz N; Nadir M; Rasheed M; Faizi S
[Ad] Endereço:a Department of Chemistry , University of Karachi , Karachi , Pakistan.
[Ti] Título:GC-MS profile of antimicrobial and antioxidant fractions from Cordia rothii roots.
[So] Source:Pharm Biol;54(11):2597-2605, 2016 Nov.
[Is] ISSN:1744-5116
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:CONTEXT: An ethnobotanical survey of Cordia rothii Roem. & Schult. (Boraginaceae) reveals it as a medicinal plant. OBJECTIVE: Antimicrobial and antioxidant potential evaluation and identification of chemical constituents via GC-MS of C. rothii roots fractions. To the best of our knowledge, this is the first systematic investigation of the roots exploiting GC-MS. MATERIALS AND METHODS: Extraction and fractionation of C. rothii roots furnished various fractions using solvents of varying polarity, i.e., n-hexane, chloroform, ethyl acetate, acetone and methanol. In vitro antimicrobial and antioxidant screening was performed using disk diffusion and DPPH methods, respectively. MIC of active fractions was also determined using disk diffusion method. GC-MS was used to identify constituents which may be responsible for these activities. RESULTS: Among various fractions from C. rothii roots, fraction KA-C showed strong antibacterial activity against 17 microorganisms tested, with MIC ranging from 250-31.25 µg/mL. Fractions KA-A, KM and KM-A exhibited significant antioxidant potential with EC 46.875 µg/mL, while fractions KEA-PE, KM-PE and KM-M were good with EC 93.750 µg/mL. Forty-five phytochemicals were identified in GC-MS studies including eight hydrocarbons, six free fatty acids, 11 fatty acids esters, two phenylpropanoids, four aromatics, four terpenoid quinones/hydroquinones, three triterpenes, four phytosterols, two hexose metabolites and a DNA base. Of these, 32 constituents have been reported for the first time from C. rothii, 24 from genus Cordia and 15 from Boraginaceae. DISCUSSION AND CONCLUSION: Strong antibacterial and antioxidant potential of C. rothii roots may be due to the contribution of phytoconstituents identified through GC-MS studies.
[Mh] Termos MeSH primário: Anti-Infecciosos/análise
Antioxidantes/análise
Cordia/química
Cromatografia Gasosa-Espectrometria de Massas/métodos
Extratos Vegetais/análise
[Mh] Termos MeSH secundário: Anti-Infecciosos/farmacologia
Antioxidantes/farmacologia
Extratos Vegetais/farmacologia
Raízes de Plantas/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Infective Agents); 0 (Antioxidants); 0 (Plant Extracts)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170207
[Lr] Data última revisão:
170207
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160528
[St] Status:MEDLINE


  6 / 93 MEDLINE  
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[PMID]:27209428
[Au] Autor:Moura Mdel G; Lopes LC; Biavatti MW; Busse JW; Wang L; Kennedy SA; Bhatnaga N; Bergamaschi Cde C
[Ad] Endereço:Department of Pharmaceutical Sciences, University of Sorocaba, Sorocaba, São Paulo, Brazil.
[Ti] Título:Brazilian oral herbal medication for osteoarthritis: a systematic review protocol.
[So] Source:Syst Rev;5:86, 2016 May 21.
[Is] ISSN:2046-4053
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Osteoarthritis affects 1 % of the world's population and is the most common cause of musculoskeletal impairment in the elderly. Herbal medications are commonly used in Brazil to manage symptoms associated with osteoarthritis, and some of them are financed by the Brazilian government; however, the effectiveness of most of these agents is uncertain. The aim was to systematically review the efficacy and safety of 13 oral herbal medications used in Brazil for the treatment of osteoarthritis. METHODS: Randomized clinical trials eligible for our systematic review will enroll adults with osteoarthritis treated by a Brazilian herbal medication or a control group (placebo or active control). Using terms to include all forms of osteoarthritis combined with herbal medications, we will search the following electronic databases: Cochrane Central Register of Controlled Trials (CENTRAL); MEDLINE; EMBASE; CINAHL; Web of Science; Health Star; AMED, the database of the Cochrane Complementary Medicine Field, LILACS; CAB abstracts, Clinical trial.gov, WHO trials registry, and Bank of Brazil Thesis (CAPES), to 31 January 2016, without restrictions concerning language or status of publication. Outcomes of interest include the following: symptom relief (e.g., pain), adverse events (gastrointestinal bleeding, epigastric pain, nausea, and allergic reactions), discontinuation due to adverse events, quality of life, and the satisfaction with the treatment. Dichotomous data will be summarized as risk ratios; continuous data will be given as standard average differences with 95 % confidence intervals. A team of reviewers will assess each citation independently for eligibility and in duplicate it. For eligible studies, the same reviewers will perform data extraction, bias risk assessment, and determination of the overall quality of evidence for each of the outcomes using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) classification system. DISCUSSION: This is the first study that will evaluate the use of herbal medications used in Brazil for the treatment of pain caused by osteoarthritis. The results could guide prescribers in decision-making in clinical practice, to inform the patients with pain caused by osteoarthritis in relation to effective and safe treatment options and to inform the managers of the public health system which of the plants could actually be financed by the Brazilian government. SYSTEMATIC REVIEW REGISTRATION: PROSPERO 42015019793.
[Mh] Termos MeSH primário: Osteoartrite/tratamento farmacológico
Fitoterapia
Preparações de Plantas/uso terapêutico
[Mh] Termos MeSH secundário: Boswellia
Brasil
Unha-de-Gato
Chenopodium ambrosioides
Cordia
Curcuma
Fabaceae
Harpagophytum
Seres Humanos
Persea
Salix
Resultado do Tratamento
Uncaria
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; REVIEW
[Nm] Nome de substância:
0 (Plant Preparations)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160523
[St] Status:MEDLINE
[do] DOI:10.1186/s13643-016-0261-1


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[PMID]:27101557
[Au] Autor:Semple HA; Sloley BD; Cabanillas J; Chiu A; Aung SK; Green FH
[Ti] Título:Toxicology of a Peruvian botanical remedy to support healthy liver function.
[So] Source:J Complement Integr Med;13(2):163-73, 2016 Jun 01.
[Is] ISSN:1553-3840
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The purpose of these studies was to determine the safety of a botanical treatment for supporting healthy liver function developed in Peru. The formulation, A4+, contains extracts of Curcuma longa L. rhizome (A4R), Cordia lutea Lam. flower (A4F) and Annona muricata L. leaf (A4L). The tests were used to support an application for a non-traditional Natural Health Product Licence from the Natural Health Product Directorate of Health Canada and future clinical trials. METHODS: Besides reviewing the scientific and clinical information from Peru on the ingredients and conducting an initial Ames test for mutagenicity, we analysed A4+ for its chemical profile and tested genotoxicity (micronucleus test) and general toxicity (28-day repeated dose). RESULTS: A4+ and extracts from the three plants provided distinctive chemical fingerprints. A4L contained acetogenins, requiring a second chromatographic method to produce a specific fingerprint. The Ames test proved positive at the highest concentration (5,000 µg/mL) but A4+ showed no evidence of genotoxicity in the more specific mouse micronucleus test. The 28-day repeated dose (general toxicity) study in rats showed no toxicity at 2,000 mg/kg. CONCLUSIONS: We conclude that under the conditions of these studies, A4+ shows no evidence of toxicity at the levels indicated. A no observed adverse effect level (NOAEL) of 2,000 mg/kg was assigned.
[Mh] Termos MeSH primário: Annona/toxicidade
Cordia/toxicidade
Curcuma/toxicidade
Fígado/efeitos dos fármacos
Extratos Vegetais/toxicidade
[Mh] Termos MeSH secundário: Animais
Etnofarmacologia
Camundongos
Nível de Efeito Adverso não Observado
Peru
Ratos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Extracts); 856YO1Z64F (turmeric extract)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170405
[Lr] Data última revisão:
170405
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160422
[St] Status:MEDLINE


  8 / 93 MEDLINE  
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Athayde, Margareth L
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[PMID]:27033000
[Au] Autor:Matias EFF; Alves EF; Silva MKN; Carvalho VRA; Medeiros CR; Santos FAV; Bitu VCN; Souza CES; Figueredo FG; Boligon AA; Athayde ML; Costa JGM; Coutinho HDM
[Ad] Endereço:Faculdade Leão Sampaio - FALS, Juazeiro do Norte, CE, Brazil.
[Ti] Título:Potentiation of antibiotic activity of aminoglycosides by natural products from Cordia verbenacea DC.
[So] Source:Microb Pathog;95:111-116, 2016 Jun.
[Is] ISSN:1096-1208
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Medicinal plants are often the only therapeutic resource for many communities and ethnic groups. Cordia verbenacea DC., "Erva-baleeira," is one of the species of plants currently used to produce a phytotherapeutic product extracted from its leaves. The present study aimed to establish its chemical profile, antibacterial activity and resistance-modulating potential. The C. verbenacea extracts were prepared from fresh leaves using solvents as methanol and hexane. Ethyl Acetate was used for the preparation of the fraction. Phytochemical screening was carried out using HPLC-DAD for determination and quantification of the secondary metabolites present in the fractions. Antibacterial and resistance-modulation assays were performed to determine minimum inhibitory concentration (MIC) using a microdilution assay. The data were subjected to statistical analysis with two-way ANOVA and Bonferroni posttests. Results of phytochemical prospecting and HPLC analysis of the fractions were in agreement with the literature. The natural products presented moderate antibacterial activity when considering the clinical relevance of a MIC of 256 µg/mL against Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa, and 512 µg/mL against P. aeruginosa. However, when the fractions were combined with antibiotics we observed a synergic effect, as natural products enhanced the antibacterial effect of aminoglycosides, significantly decreasing the MIC of antibiotics at 12.5%-98.4%. We believe that the data obtained from phytochemical analysis and from antibacterial and resistance modulation assays of C. verbenacea extracts new can open perspectives in the search for new alternatives for the treatment of bacterial infections and stimulate the renewed use of antibiotics with reduced effectiveness due to resistance.
[Mh] Termos MeSH primário: Aminoglicosídeos/farmacologia
Antibacterianos/farmacologia
Produtos Biológicos/farmacologia
Cordia/química
Sinergismo Farmacológico
Compostos Fitoquímicos/farmacologia
[Mh] Termos MeSH secundário: Antibacterianos/isolamento & purificação
Produtos Biológicos/isolamento & purificação
Cromatografia Líquida de Alta Pressão
Escherichia coli/efeitos dos fármacos
Testes de Sensibilidade Microbiana
Compostos Fitoquímicos/análise
Compostos Fitoquímicos/isolamento & purificação
Folhas de Planta/química
Pseudomonas aeruginosa/efeitos dos fármacos
Staphylococcus aureus/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Aminoglycosides); 0 (Anti-Bacterial Agents); 0 (Biological Products); 0 (Phytochemicals)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170904
[Lr] Data última revisão:
170904
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160402
[St] Status:MEDLINE


  9 / 93 MEDLINE  
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[PMID]:26968538
[Au] Autor:El-Newary SA; Sulieman AM; El-Attar SR; Sitohy MZ
[Ad] Endereço:Department of Aromatic and Medicinal Plants Research, National Research Center, Dokki, Giza, 12311, Egypt. samahelnewary@yahoo.com.
[Ti] Título:Hypolipidemic and antioxidant activity of the aqueous extract from the uneaten pulp of the fruit from Cordia dichotoma in healthy and hyperlipidemic Wistar albino rats.
[So] Source:J Nat Med;70(3):539-53, 2016 Jul.
[Is] ISSN:1861-0293
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:Hyperlipidemia is a major risk factor for coronary heart disease. Hyperlipidemia increases the incidence of myocardial ischemia and cardiac events. This study evaluated the potential hypolipidemic and antioxidant action of the aqueous extract from the uneaten pulp of the fruit from Cordia dichotoma ("CDNP extract"). In vivo studies were performed for 10 weeks on dietary hyperlipidemic and healthy Wistar albino rat models that received two dose levels of the CDNP extract (0.50 and 1.00 g/kg body weight). Serum lipid profiles were determined for the experimental animals. Dietary hyperlipidemic rats were characterized by an elevated lipid profile compared to the healthy control, i.e., increased levels of serum total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), very low density lipoprotein cholesterol (VLDL-C), and triglycerides (TG), although the level of high-density lipoprotein (HDL-C) was reduced. Levels of antioxidant enzymes, i.e., glutathione reductase (GR), glutathione peroxidase (GPx), glutathione-S-transferase (GST), superoxide dismutase (SOD), and catalase (CAT), were significantly higher in the dietary hyperlipidemic rats than in the normal healthy ones, while the level of malondialdehyde (MDA) was significantly lower. Force-feeding hyperlipidemic Wistar albino rats with the CDNP extract at two doses decreased TC, LDL-C, VLDL-C, and TG to normal levels. The risk ratio, which was as high as 870 % for the hyperlipidemic rats was decreased by the treatment to levels close to that calculated for the healthy control rats. Levels of high-density lipoprotein cholesterol (HDL-C) were very low in the hyperlipidemic Wistar albino rats but increased significantly when CDNP extract was adminstered, attaining similar HDL-C levels to those of healthy control rats. Treatment with the CDNP extract also improved the levels of antioxidant enzymes (GR, GST, GPx, SOD, and CAT) in hyperlipidemic Wistar albino rats. Thus, the CDNP extract improves the lipid metabolism of healthy and hyperlipidemic Wistar albino rats and can be employed in the management of dietary hyperlipidemia.
[Mh] Termos MeSH primário: Cordia/química
Frutas/química
Hiperlipidemias/sangue
Hipolipemiantes/uso terapêutico
Triglicerídeos/metabolismo
[Mh] Termos MeSH secundário: Animais
Antioxidantes
Modelos Animais de Doenças
Masculino
Ratos
Ratos Wistar
Fatores de Risco
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Hypolipidemic Agents); 0 (Triglycerides)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:171104
[Lr] Data última revisão:
171104
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160313
[St] Status:MEDLINE
[do] DOI:10.1007/s11418-016-0973-5


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[PMID]:26501159
[Au] Autor:Osho A; Otuechere CA; Adeosun CB; Oluwagbemi T; Atolani O
[Ti] Título:Phytochemical, sub-acute toxicity, and antibacterial evaluation of Cordia sebestena leaf extracts.
[So] Source:J Basic Clin Physiol Pharmacol;27(2):163-70, 2016 Mar.
[Is] ISSN:2191-0286
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: In Nigeria, Cordia sebestena (Boraginaceae), an understudied medicinal plant, is used in traditional medicine for the treatment of gastrointestinal disorders. In this study, we investigated the chemical composition, antibacterial potential, and sub-acute toxicity of C. sebestena leaves. METHODS: Ethyl acetate extracts were analyzed using thin layer chromatography (TLC) and Fourier transform infrared (FTIR) spectrophotometry. The antibacterial potential of the extracts was tested against five standard bacteria, namely Bacillus cereus, Bacillus subtilis, Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa. Clinical observations and blood parameters were used to evaluate the possible toxicity of C. sebestena. RESULTS: The TLC profile yielded 39 fractions, which were pooled to nine combined sub-fractions (A-I). The FTIR spectrum of sub-fraction H indicated the presence of aliphatic C-H stretching vibration at 2922 and 2850 cm-1, C=O stretch at 1734 and 1708 cm-1, and C=C stretch of aromatics and aliphatics at 1464 and (shoulder) 1618 cm-1, respectively. The fractions of the C. sebestena ethyl acetate leaf extract showed antibacterial potential across board, but fraction H had the highest antibacterial activity against B. cereus and S. aureus. The study also indicated the relatively low toxicity profile of the ethyl acetate leaf extract of C. sebestena in the liver of rats. CONCLUSIONS: The study showed that C. sebestena leaves have strong antibacterial potential and low toxicity, thereby underlying the scientific basis for their folkloric use in the management of microbial infections and its associated complications.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Bactérias/efeitos da radiação
Cordia/química
Compostos Fitoquímicos/farmacologia
Extratos Vegetais/farmacologia
Folhas de Planta/química
[Mh] Termos MeSH secundário: Animais
Masculino
Plantas Medicinais/química
Ratos
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Phytochemicals); 0 (Plant Extracts)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151027
[St] Status:MEDLINE



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