Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.150.444 [Categoria DeCS]
Referências encontradas : 63 [refinar]
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[PMID]:28927792
[Au] Autor:Cai YS; Sarotti AM; Gündisch D; Kondratyuk TP; Pezzuto JM; Turkson J; Cao S
[Ad] Endereço:Department of Pharmaceutical Sciences, Daniel K. Inouye College of Pharmacy, University of Hawaii at Hilo, 200 West Kawili Street, Hilo, HI 96720, United States; Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, School of Pharmaceutical Sciences, Wuhan Universit
[Ti] Título:Heliotropiumides A and B, new phenolamides with N-carbamoyl putrescine moiety from Heliotropium foertherianum collected in Hawaii and their biological activities.
[So] Source:Bioorg Med Chem Lett;27(20):4630-4634, 2017 10 15.
[Is] ISSN:1464-3405
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Two new compounds heliotropiumides A (1) and B (2), phenolamides each with an uncommon carbamoyl putrescine moiety, were isolated from the seeds of a naturalized Hawaiian higher plant, Heliotropium foertherianum Diane & Hilger in the borage family, which is widely used for the treatment of ciguatera fish poisoning. The structures of compounds 1 and 2 were characterized based on MS spectroscopic and NMR analysis, and DP4+ calculations. The absolute configuration (AC) of compound 1 was determined by comparison of its optical rotation with those reported in literature. Compound 2 showed inhibition against NF-κB with an IC value of 36µM.
[Mh] Termos MeSH primário: Amidas/farmacologia
Benzofuranos/química
Heliotropium/química
Fenóis/química
Extratos Vegetais/química
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Amidas/química
Amidas/toxicidade
Anti-Infecciosos/química
Anti-Infecciosos/isolamento & purificação
Anti-Infecciosos/farmacologia
Antineoplásicos Alquilantes/química
Antineoplásicos Alquilantes/isolamento & purificação
Antineoplásicos Alquilantes/farmacologia
Benzofuranos/farmacologia
Benzofuranos/toxicidade
Linhagem Celular Tumoral
Sobrevivência Celular/efeitos dos fármacos
Fungos/efeitos dos fármacos
Bactérias Gram-Negativas/efeitos dos fármacos
Bactérias Gram-Positivas/efeitos dos fármacos
Heliotropium/metabolismo
Seres Humanos
Espectroscopia de Ressonância Magnética
Conformação Molecular
NF-kappa B/antagonistas & inibidores
NF-kappa B/metabolismo
Fenóis/farmacologia
Fenóis/toxicidade
Extratos Vegetais/uso terapêutico
Putrescina/química
Intoxicação por Frutos do Mar/prevenção & controle
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, N.I.H., EXTRAMURAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Amides); 0 (Anti-Infective Agents); 0 (Antineoplastic Agents, Alkylating); 0 (Benzofurans); 0 (NF-kappa B); 0 (Phenols); 0 (Plant Extracts); 0 (heliotropiumide A); 0 (heliotropiumide B); V10TVZ52E4 (Putrescine)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171125
[Lr] Data última revisão:
171125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170921
[St] Status:MEDLINE


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[PMID]:28125883
[Au] Autor:Fu PP; Xia Q; He X; Barel S; Edery N; Beland FA; Shimshoni JA
[Ad] Endereço:National Center for Toxicological Research , Jefferson, Arkansas 72079, United States.
[Ti] Título:Detection of Pyrrolizidine Alkaloid DNA Adducts in Livers of Cattle Poisoned with Heliotropium europaeum.
[So] Source:Chem Res Toxicol;30(3):851-858, 2017 Mar 20.
[Is] ISSN:1520-5010
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Pyrrolizidine alkaloids are among the most common poisonous plants affecting livestock, wildlife, and humans. Exposure of humans and livestock to toxic pyrrolizidine alkaloids through the intake of contaminated food and feed may result in poisoning, leading to devastating epidemics. During February 2014, 73 mixed breed female beef cows from the Galilee region of Israel were accidently fed pyrrolizidine alkaloid contaminated hay for 42 days, resulting in the sudden death of 24 cows over a period of 63 days. The remaining cows were slaughtered 2.5 months after the last ingestion of the contaminated hay. In this study, we report the histopathological analysis of the livers from five of the slaughtered cows and quantitation of pyrrolizidine alkaloid-derived DNA adducts from their livers and three livers of control cows fed with feed free of weeds producing pyrrolizidine alkaloids. Histopathological examination revealed that the five cows suffered from varying degrees of bile duct proliferation, fibrosis, and megalocytosis. Selected reaction monitoring HPLC-ES-MS/MS analysis indicated that (±)-6,7-dihydro-7-hydroxy-1-hydroxymethyl-5H-pyrrolizine (DHP)-derived DNA adducts were formed in all five livers. The livers from the three control cows did not have any liver damage nor any indication of DHP-DNA adduct formed. These results confirm that the toxicity observed in these cattle was caused by pyrrolizidine alkaloid poisoning and that pyrrolizidine alkaloid-derived DNA adducts could still be detected and quantified in the livers of the chronically poisoned cows 2.5 months after their last exposure to the contaminated feed, suggesting that DHP-derived DNA adducts can serve as biomarkers for pyrrolizidine alkaloid exposure and poisoning.
[Mh] Termos MeSH primário: Adutos de DNA/química
Heliotropium/fisiologia
Fígado/química
Plantas Tóxicas/toxicidade
Alcaloides de Pirrolizidina/química
[Mh] Termos MeSH secundário: Animais
Bovinos
Cromatografia Líquida
Fígado/patologia
Espectrometria de Massas em Tandem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA Adducts); 0 (Pyrrolizidine Alkaloids)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170614
[Lr] Data última revisão:
170614
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170128
[St] Status:MEDLINE
[do] DOI:10.1021/acs.chemrestox.6b00456


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[PMID]:28480379
[Au] Autor:Ghaffari MA; Chaudhary BA; Uzair M; Ashfaq K
[Ad] Endereço:Faculty of Pharmacy, Bahauddin Zakriya University, Multan, Pakistan.
[Ti] Título:CYTOTOXIC, α-CHYMOTRYPSIN AND UREASE INHIBITION ACTIVITIES OF THE PLANT L.
[So] Source:Afr J Tradit Complement Altern Med;13(6):194-198, 2016.
[Is] ISSN:2505-0044
[Cp] País de publicação:Nigeria
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The aim of this study was to investigate Cytotoxic, α-Chymotrypsin and Urease inhibition activities of the plant . MATERIALS & METHODS: Dichloromethane and methanol extracts of the plant were evaluated for cytotoxic, α-Chymotrypsin and Urease inhibition by using Brine Shrimp lethality bioassay and enzymatic inhibition assays respectively. RESULTS: The methanol extract of the plant exhibited significant cytotoxic activity. Out of 30 brine shrimp larvae, 2 (6%), 26 (86%) and 28 (93%) larvae were survived at concentration of 1000µg/ml, 100µg/ml and 10µg/ml respectively with LD50; 215.837. Similarly 21 (70%), 25 (83%), 29 (96%) larvae were survived of dichloromethane plant extract with LD50; 6170.64. The methanol and dichloromethane extract exhibited 10.50±0.18% and 41.51±0.15% α-chymotrypsin enzyme inhibition respectively with IC values of greater than 500 µmol. The methanol extract showed 24.39±0.21% Urease enzyme inhibition with IC values of greater than 400 µmol While dichloromethane extract has 11.46±0.09% enzyme inhibition with IC values of greater than 500 µmol. CONCLUSION: The results clearly indicated that has cytotoxic potential and enzyme inhibition properties. Further study is needed to screen out antitumor and anti-ulcerative agents.
[Mh] Termos MeSH primário: Quimotripsina/antagonistas & inibidores
Citotoxinas/farmacologia
Heliotropium/química
Extratos Vegetais/farmacologia
Urease/antagonistas & inibidores
[Mh] Termos MeSH secundário: Animais
Artemia
Metanol/farmacologia
Cloreto de Metileno/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cytotoxins); 0 (Plant Extracts); 588X2YUY0A (Methylene Chloride); EC 3.4.21.1 (Chymotrypsin); EC 3.4.21.1 (alpha-chymotrypsin); EC 3.5.1.5 (Urease); Y4S76JWI15 (Methanol)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170929
[Lr] Data última revisão:
170929
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170509
[St] Status:MEDLINE
[do] DOI:10.21010/ajtcam.v13i6.28


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[PMID]:27597961
[Au] Autor:Ahmad S; AbdEl-Salam NM; Ullah R
[Ad] Endereço:Department of Chemistry, Qurtuba University of Science and Information Technology Peshawar, Peshawar 25120, Pakistan.
[Ti] Título:In Vitro Antimicrobial Bioassays, DPPH Radical Scavenging Activity, and FTIR Spectroscopy Analysis of Heliotropium bacciferum.
[So] Source:Biomed Res Int;2016:3818945, 2016.
[Is] ISSN:2314-6141
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The present study deals with the antimicrobial, antioxidant, and functional group analysis of Heliotropium bacciferum extracts. Disc diffusion susceptibility method was followed for antimicrobial assessment. Noteworthy antimicrobial activities were recorded by various plant extracts against antibiotic resistant microorganisms. Plant flower extracts antioxidant activity was investigated against 2, 2-diphenyl-1-picryl hydrazyl radical by ultraviolet spectrophotometer (517 nm). Plant extracts displayed noteworthy radical scavenging activities at all concentrations (25-225 µg/mL). Notable activities were recorded by crude, chloroform and ethyl acetate extracts up to 88.27% at 225 µg/mL concentration. Compounds functional groups were examined by Fourier transform infrared spectroscopic studies. Alkanes, alkenes, alkyl halides, amines, carboxylic acids, amides, esters, alcohols, phenols, nitrocompounds, and aromatic compounds were identified by FTIR analysis. Thin layer chromatography bioautography was carried out for all plant extracts. Different bands were separated by various solvent systems. The results of the current study justify the use of Heliotropium bacciferum in traditional remedial herbal medicines.
[Mh] Termos MeSH primário: Antibacterianos/administração & dosagem
Fenômenos Fisiológicos Bacterianos/efeitos dos fármacos
Compostos de Bifenilo/química
Heliotropium/química
Picratos/química
Extratos Vegetais/administração & dosagem
Extratos Vegetais/química
[Mh] Termos MeSH secundário: Antibacterianos/química
Bioensaio/métodos
Compostos de Bifenilo/isolamento & purificação
Sobrevivência Celular/efeitos dos fármacos
Sobrevivência Celular/fisiologia
Depuradores de Radicais Livres/química
Radicais Livres/química
Radicais Livres/isolamento & purificação
Heliotropium/classificação
Picratos/isolamento & purificação
Plantas Medicinais/química
Plantas Medicinais/classificação
Especificidade da Espécie
Espectroscopia de Infravermelho com Transformada de Fourier/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Biphenyl Compounds); 0 (Free Radical Scavengers); 0 (Free Radicals); 0 (Picrates); 0 (Plant Extracts); DFD3H4VGDH (1,1-diphenyl-2-picrylhydrazyl)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160907
[St] Status:MEDLINE
[do] DOI:10.1155/2016/3818945


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[PMID]:26690664
[Au] Autor:Valenzuela B; Obreque J; Soto-Aguilera S; Maisey K; Imarai M; Modak B
[Ad] Endereço:Laboratory of Immunology, Center of Aquatic Biotechnology, Department of Biology, Faculty of Chemistry and Biology, University of Santiago of Chile, Av. Bernardo O'Higgins, 3363 Santiago, Chile. Electronic address: beatriz.valenzuelam@usach.cl.
[Ti] Título:Key cytokines of adaptive immunity are differentially induced in rainbow trout kidney by a group of structurally related geranyl aromatic derivatives.
[So] Source:Fish Shellfish Immunol;49:45-53, 2016 Feb.
[Is] ISSN:1095-9947
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Filifolinone is a semi-synthetic terpenoid derivative obtained from Heliotropium filifolium that increases the expression level of pro-inflammatory and anti-inflammatory cytokines in kidney cells of salmon. Because cytokines are produced in response to a foreign organism and by distinct other signals modulating immune responses, we further studied the potential immunomodulatory effects of a group of structural related terpenoid derivatives from H. filifolium on salmonids to determine the relationship between the chemical structure of the derivatives and their ability to modify cytokine expression and the lymphoid content. The resin and four 3H-spiro 1-benzofuran-2,1'-cyclohexane derivatives were tested in vivo in rainbow trout (Oncorhynchus mykiss) by quantifying the transcript levels of antiviral and T helper-type cytokines and T and B cells in the kidney. Three of the four terpenoids differ only in the C-7'substituent of the cyclohexane and the presence of the ketone group at this position in Filifolinone appeared responsible of an important up-regulation of IFN-α1, IFN-γ, IL-4/13A and IL-17D in the kidney of the treated trout. In addition, the absence of a methoxy group in carbon 7 of the benzene ring, found in all compounds but not in Folifolinoic acid, produced a significant reduction of IFN-γ, IL-12 and IL-4/13A transcripts. B cells were not affected by the compound treatment but Filifolinoic acid and the resin induced a significant reduction of T cells. Altogether, results showed that immunomodulating responses observed in the trout by effect of 3H-spiro 1-benzofuran-2,1'-cyclohexane derivatives is related to the presence of the ketone group in the carbon 7' and the methoxy group in carbon 7 of the benzene ring, being Filifolinone the most active immunostimulatory compound identified.
[Mh] Termos MeSH primário: Imunidade Adaptativa/efeitos dos fármacos
Imunidade Adaptativa/genética
Citocinas/genética
Regulação da Expressão Gênica
Imunomodulação
Oncorhynchus mykiss/imunologia
[Mh] Termos MeSH secundário: Animais
Benzofuranos/farmacologia
Citocinas/metabolismo
Heliotropium/química
Injeções Intramusculares/veterinária
Tecido Linfoide/efeitos dos fármacos
Tecido Linfoide/metabolismo
Oncorhynchus mykiss/genética
Oncorhynchus mykiss/metabolismo
Distribuição Aleatória
Terpenos/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Benzofurans); 0 (Cytokines); 0 (Terpenes)
[Em] Mês de entrada:1611
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151223
[St] Status:MEDLINE


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[PMID]:24334553
[Au] Autor:Khan H; Khan MA; Hussain S; Gaffar R; Ashraf N
[Ad] Endereço:Gandhara College of Pharmacy, Gandhara University, Peshawar, Pakistan Department of Pharmacy, Abdul Wali Khan University, Mardan, Pakistan hkdr2006@gmail.com.
[Ti] Título:In vivo antinociceptive and anticonvulsant activity of extracts of Heliotropium strigosum.
[So] Source:Toxicol Ind Health;32(5):860-5, 2016 May.
[Is] ISSN:1477-0393
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Natural healing agents are primarily focused to overcome unwanted side effects with synthetic drugs worldwide. In the proposed study, crude extracts and subsequent solvent fractions of Heliotropium strigosum were evaluated for antinociceptive and anticonvulsant activity in animal paradigms. In post acetic acid-induced writhing test, crude extract and fractions (hexane, ethyl acetate, and aqueous) demonstrated marked attenuation of nociception at test doses (50, 100, and 200 mg/kg i.p.). When challenged against thermally induced pain model, pretreatment of extracts exhibited prominent amelioration at test dose (50, 100, and 200 mg/kg i.p.). In both tests, inhibition of noxious stimulation was in a dose-dependent manner, and ethyl acetate fraction was most dominant. However, extracts did not antagonize the seizures and mortality induced by pentylenetetrazole. In conclusion, the extracts of H. strigosum illustrated significant antinociceptive effect in both centrally and peripherally acting pain models.
[Mh] Termos MeSH primário: Analgésicos/farmacologia
Anticonvulsivantes/farmacologia
Heliotropium/química
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Animais
Relação Dose-Resposta a Droga
Feminino
Masculino
Camundongos
Dor/induzido quimicamente
Dor/tratamento farmacológico
Pentilenotetrazol/toxicidade
Ratos
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Analgesics); 0 (Anticonvulsants); 0 (Plant Extracts); WM5Z385K7T (Pentylenetetrazole)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170418
[Lr] Data última revisão:
170418
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:131217
[St] Status:MEDLINE
[do] DOI:10.1177/0748233713513489


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[PMID]:27295812
[Au] Autor:Owolabi MA; Oribayo OO; Ukpo GE; Mbaka GO; Akindehin OE
[Ti] Título:A 5-month toxicity study of the ethanol extract of the leaves of Heliotropium indicum in Sprague Dawley rats after oral administration.
[So] Source:Nig Q J Hosp Med;25(3):184-92, 2015 Jul-Sep.
[Is] ISSN:0189-2657
[Cp] País de publicação:Nigeria
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Heliotropium indicum Linn. (Boraginaceae) is used in Nigerian traditional medicine to treat tuberculosis with treatment lasting for 3 months; however, information on its toxicity is scarce. OBJECTIVE: This study investigated the safety of the leaves of Heliotropium indicum after a 5 month oral administration. METHODS: The leaves of H. indicum were dried; extracted in 70% ethanol and concentrated to dryness. Swiss mice were administered orally with single doses of the extract (0.5 to 12.0 g/kg b.wt /day); mortality was examined for up to 14 days. In another study, the plant material (0.5 to 2.0 g/kg b.wt /day) were administered daily by oral gavage to Sprague Dawley rats. Body weight was monitored weekly, hematological, biochemical and organ parameters were determined at the end of the 1st, 2nd and 5th months of extract administration. RESULTS: The oral administration of the ethanol extract of H. indicum caused dose-dependent mortality. The LD50 was 9.78 g/kg b.wt for the Swiss mice; no harmful effect was observed on the liver and kidney except the testes which exhibited considerable inflammatory changes at the highest dose of 2.0 g/kg b.wt./day after the 5th month treatment. No significant difference (P>0.05) was shown in the enzyme study, marginal increase occurred in some haematological parameters. The increase in body weight of the treated rats after its initial reduction was consistent and significantly different (P<0.05) from their initial body weight. CONCLUSION: Prolonged administration of the crude leaf extract of H. indicum is considered to be safe and nontoxic at the doses studied. However, there is a probability of a negative effect on the testes at a higher dose of the extract.
[Mh] Termos MeSH primário: Heliotropium/toxicidade
Extratos Vegetais/toxicidade
Folhas de Planta/toxicidade
[Mh] Termos MeSH secundário: Administração Oral
Animais
Análise Química do Sangue
Feminino
Rim/efeitos dos fármacos
Dose Letal Mediana
Fígado/efeitos dos fármacos
Pulmão/efeitos dos fármacos
Masculino
Camundongos
Nigéria
Extratos Vegetais/administração & dosagem
Ratos
Ratos Sprague-Dawley
Testículo/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Extracts)
[Em] Mês de entrada:1607
[Cu] Atualização por classe:160614
[Lr] Data última revisão:
160614
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160615
[St] Status:MEDLINE


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[PMID]:26728771
[Au] Autor:Singh B; Sharma RA
[Ad] Endereço:Institute of Biotechnology, Amity University Rajasthan, Jaipur-303 002, India. bharatsingh217@gmail.com.
[Ti] Título:Anti-Inflammatory and Antimicrobial Properties of Flavonoids from Heliotropium subulatum Exudate.
[So] Source:Inflamm Allergy Drug Targets;14(2):125-32, 2015.
[Is] ISSN:2212-4055
[Cp] País de publicação:United Arab Emirates
[La] Idioma:eng
[Ab] Resumo:Heliotropium subulatum is an erect or procumbent perennial herb; leaves contain foliar trichomes and its resinous exudate is used in traditional medicine. The anti-inflammatory activity of dichloromethane fraction and isolated flavonoids was evaluated by using carrageenan and CFA-induced paw oedema models. Similarly, the disc diffusion and microdilution methods were used for the assessment of antimicrobial activity. Five isolated flavonoids were investigated for their antiinflammatory and antimicrobial activities. Eriodictyol demonstrated maximum anti-inflammatory activity (53.09%) at 30.0 mg/kg dose on 6(th) h and similarly, it inhibited the CFA-induced arthritis swelling (41.84%) with 30.0 mg/kg dose on 8(th) day respectively. As per disc diffusion and microdilution methods used for antimicrobial activity determination, the pinocembrin was found to be most active against Staphylococcus aureus (IZ=27±0.7 mm, 08 µg/ml dose) and Candida albicans (IZ=17±0.9 mm; 12 µg/ml dose). These investigated results revealed that the eriodictyol and pinocembrin showed significant anti-inflammatory and antimicrobial activities. Further studies which aimed to investigate the mechanism of action of these isolated flavonoids in the treatment of inflammations and various types of infections have been initiated.
[Mh] Termos MeSH primário: Anti-Infecciosos/farmacologia
Anti-Inflamatórios/farmacologia
Artrite Experimental/prevenção & controle
Candida albicans/efeitos dos fármacos
Edema/prevenção & controle
Heliotropium/química
Extratos Vegetais/farmacologia
Resinas Vegetais/farmacologia
Staphylococcus aureus/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Anti-Infecciosos/química
Anti-Infecciosos/isolamento & purificação
Anti-Inflamatórios/química
Anti-Inflamatórios/isolamento & purificação
Artrite Experimental/induzido quimicamente
Candida albicans/crescimento & desenvolvimento
Carragenina
Testes de Sensibilidade a Antimicrobianos por Disco-Difusão
Edema/induzido quimicamente
Adjuvante de Freund
Masculino
Fitoterapia
Extratos Vegetais/química
Extratos Vegetais/isolamento & purificação
Plantas Medicinais
Ratos Wistar
Resinas Vegetais/química
Resinas Vegetais/isolamento & purificação
Staphylococcus aureus/crescimento & desenvolvimento
Fatores de Tempo
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Infective Agents); 0 (Anti-Inflammatory Agents); 0 (Plant Extracts); 0 (Resins, Plant); 9000-07-1 (Carrageenan); 9007-81-2 (Freund's Adjuvant)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160106
[St] Status:MEDLINE


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[PMID]:26048286
[Au] Autor:Janbaz KH; Javed S; Saqib F; Imran I; Zia-Ul-Haq M; De Feo V
[Ad] Endereço:Faculty of Pharmacy, Bahauddin Zakariya University, Multan, Pakistan. khjanbaz@hotmail.com.
[Ti] Título:Validation of ethnopharmacological uses of Heliotropium strigosum Willd. as spasmolytic, bronchodilator and vasorelaxant remedy.
[So] Source:BMC Complement Altern Med;15:169, 2015 Jun 06.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Heliotropium strigosum is used in traditional medicine to manage gastrointestinal pain, respiratory distress and vascular disorders. The present study was undertaken to provide scientific evidences for these folkloric uses by in vitro experimental settings. METHODS: A crude methanol extract of the Heliotropium strigosum (Hs.Cr) was tested in vitro on isolated rabbit jejunum preparations to detect the possible presence of spasmolytic activity. Moreover, isolated rabbit tracheal and aorta preparations were used to ascertain the relaxant effects of the extract. RESULTS: The Hs.Cr exhibited relaxant effects in rabbit jejunum in a concentration dependent manner (0.01-3.0 mg/ml). The Hs.Cr also relaxed K(+) (80 mM)-induced spastic contractions in rabbit jejunum and shifted the Ca(2+) concentration response curves towards right. The extract relaxed carbachol (1 µM)- as well as K(+) (80 mM)-induced contractions in rabbit trachea at concentrations ranging from 0.01 to 10 mg/ml. Moreover, Hs.Cr. also relaxed (0.01-3.0 mg/ml) the phenylephrine (1 µM)- and K(+) (80 mM)-induced contractions in isolated rabbit aorta. CONCLUSIONS: The Hs.Cr was found to exhibit spasmolytic, bronchodilator and vasorelaxant activities on isolated rabbit jejunum, trachea and aorta preparations, likely mediated through Ca(2+) channel blockade. This finding may provide a scientific basis for the folkloric uses of the plant.
[Mh] Termos MeSH primário: Broncodilatadores/farmacologia
Heliotropium
Contração Muscular/efeitos dos fármacos
Músculo Liso/efeitos dos fármacos
Parassimpatolíticos/farmacologia
Extratos Vegetais/farmacologia
Vasodilatadores/farmacologia
[Mh] Termos MeSH secundário: Animais
Aorta/efeitos dos fármacos
Carbacol
Etnofarmacologia
Jejuno/efeitos dos fármacos
Masculino
Fenilefrina
Fitoterapia
Coelhos
Traqueia/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bronchodilator Agents); 0 (Parasympatholytics); 0 (Plant Extracts); 0 (Vasodilator Agents); 1WS297W6MV (Phenylephrine); 8Y164V895Y (Carbachol)
[Em] Mês de entrada:1511
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150607
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-015-0697-1


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[PMID]:25591008
[Au] Autor:Shimshoni JA; Mulder PP; Bouznach A; Edery N; Pasval I; Barel S; Abd-El Khaliq M; Perl S
[Ad] Endereço:Department of Toxicology and ‡Department of Pathology, Kimron Veterinary Institute , Bet Dagan 50250, Israel.
[Ti] Título:Heliotropium europaeum poisoning in cattle and analysis of its pyrrolizidine alkaloid profile.
[So] Source:J Agric Food Chem;63(5):1664-72, 2015 Feb 11.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Pyrrolizidine alkaloids (PAs) are carcinogenic and genotoxic phytochemicals found exclusively in angiosperms. The ingestion of PA-containing plants often results in acute and chronic toxicities in man and livestock, targeting mainly the liver. During February 2014, a herd of 15-18-month-old mixed-breed beef cattle (n = 73) from the Galilee region in Israel was accidently fed hay contaminated with 12% Heliotropium europaeum (average total PA intake was 33 mg PA/kg body weight/d). After 42 d of feed ingestion, sudden death occurred over a time period of 63 d with a mortality rate of 33%. Necropsy and histopathological examination revealed fibrotic livers and moderate ascites, as well as various degrees of hyperplasia and fibrosis of bile duct epithelial cells. Elevated γ-glutamyl-transferase and alkaline phosphatase levels were indicative of severe liver damage. Comprehensive PA profile determination of the contaminated hay and of native H. europaeum by LC-MS/MS revealed the presence of 30 PAs and PA-N-oxides, including several newly reported PAs and PA-N-oxides of the rinderine and heliosupine class. Heliotrine- and lasiocarpine-type PAs constituted 80% and 18% of the total PAs, respectively, with the N-oxides being the most abundant form (92%). The PA profile of the contaminated hay showed very strong resemblance to that of H. europaeum.
[Mh] Termos MeSH primário: Ração Animal/toxicidade
Doenças dos Bovinos/metabolismo
Doenças Transmitidas por Alimentos/veterinária
Heliotropium/toxicidade
Extratos Vegetais/toxicidade
Alcaloides de Pirrolizidina/toxicidade
[Mh] Termos MeSH secundário: Ração Animal/análise
Animais
Bovinos
Doenças dos Bovinos/etiologia
Feminino
Doenças Transmitidas por Alimentos/etiologia
Doenças Transmitidas por Alimentos/metabolismo
Heliotropium/química
Heliotropium/metabolismo
Masculino
Extratos Vegetais/química
Extratos Vegetais/metabolismo
Alcaloides de Pirrolizidina/química
Alcaloides de Pirrolizidina/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Extracts); 0 (Pyrrolizidine Alkaloids)
[Em] Mês de entrada:1509
[Cu] Atualização por classe:150211
[Lr] Data última revisão:
150211
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150116
[St] Status:MEDLINE
[do] DOI:10.1021/jf5052199



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