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Pesquisa : B01.650.940.800.575.912.250.157.600.500 [Categoria DeCS]
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[PMID]:28946118
[Au] Autor:Rybczynska-Tkaczyk K; Swiecilo A; Szychowski KA; Kornillowicz-Kowalska T
[Ad] Endereço:Department of Environmental Microbiology, Laboratory of Mycology, The University of Life Sciences, Leszczynskiego Street 7, Lublin 20-069, Poland. Electronic address: kamila.rybczynska-tkaczyk@up.lublin.pl.
[Ti] Título:Comparative study of eco- and cytotoxicity during biotransformation of anthraquinone dye Alizarin Blue Black B in optimized cultures of microscopic fungi.
[So] Source:Ecotoxicol Environ Saf;147:776-787, 2018 Jan.
[Is] ISSN:1090-2414
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The aim of this study was to select optimal conditions (C and N sources, initial pH and temperature) for biodecolorization of 0.03% anthraquinone dye Alizarin Blue Black B (ABBB) by microscopic fungi: Haematonectria haematococca BwIII43, K37 and Trichoderma harzianum BsIII33. The phenolic compounds, phytotoxicity (Lepidium sativum L.), biotoxicity (Microtox), cytotoxicity and yeast viability assay were performed to determine the extent of ABBB detoxification. Biodecolorization and detoxification of 0.03% ABBB in H. haematococca BwIII43 and T. harzianum BsIII33 cultures was correlated with extracellular oxidoreductases activity. In turn, secondary products, toxic to human fibroblasts and respiring sod1 Saccharomyces cerevisiae cells, were formed in H. haematococca K37 strain cultures, despite efficient decolorization.
[Mh] Termos MeSH primário: Antraquinonas/toxicidade
Corantes/toxicidade
Poluentes Químicos da Água/toxicidade
Purificação da Água/métodos
Leveduras/metabolismo
[Mh] Termos MeSH secundário: Antraquinonas/análise
Biodegradação Ambiental
Biotransformação
Linhagem Celular
Sobrevivência Celular/efeitos dos fármacos
Corantes/análise
Seres Humanos
Lepidium sativum/efeitos dos fármacos
Oxirredução
Testes de Toxicidade/métodos
Poluentes Químicos da Água/análise
Leveduras/efeitos dos fármacos
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anthraquinones); 0 (Coloring Agents); 0 (Water Pollutants, Chemical)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170926
[St] Status:MEDLINE


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[PMID]:28466005
[Au] Autor:Vadivelan G; Rao PP; Venkateswaran G
[Ad] Endereço:Microbiology & Fermentation Technology Department, CSIR-Central Food Technological Research Institute, Mysore, India.
[Ti] Título:Influence of Supplementation of Vegetable Oil Blends on Omega-3 Fatty Acid Production in CFR-GV15.
[So] Source:Biomed Res Int;2017:1432970, 2017.
[Is] ISSN:2314-6141
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Objectives of this study were designed for improved production of mycelial omega-3 fatty acids with particular reference to EPA and DHA from the oleaginous fungus CFR-GV15 under submerged low temperatures fermentation supplemented with linseed oil and garden cress oil as an additional energy source. The fungus was grown at 20°C temperature for four days initially followed by 12°C temperature for next five days. The basal medium contained starch, yeast extract, and a blend of linseed oil (LSO) and garden cress oil (GCO) in the ratio 1 : 1. Results of the study revealed that, after nine days of total incubation period, the enhancement of biomass was up to 16.7 g/L dry weight with a total lipid content of 55.4% (v/w). Enrichment of omega-3 fatty acids indicated a significant increase in fatty acid bioconversion (ALA 32.2 ± 0.42%, EPA 7.9 ± 0.1%, and DHA 4.09 ± 0.2%) by 2.5-fold. The two-stage temperature cultivation alters the fatty acid profile due to activation of the desaturase enzyme in the cellular levels due to which arachidonic acid (AA) content reduced significantly. It can be concluded that CFR-GV15 is a fungal culture suitable for commercial production of PUFAs with enriched EPA and DHA.
[Mh] Termos MeSH primário: Ácido Araquidônico/química
Ácidos Graxos Ômega-3/química
Óleo de Semente do Linho/química
Óleos Vegetais/química
[Mh] Termos MeSH secundário: Biomassa
Temperatura Baixa
Suplementos Nutricionais
Fermentação
Lepidium sativum/química
Mortierella/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fatty Acids, Omega-3); 0 (Plant Oils); 27YG812J1I (Arachidonic Acid); 8001-26-1 (Linseed Oil)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180216
[Lr] Data última revisão:
180216
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170504
[St] Status:MEDLINE
[do] DOI:10.1155/2017/1432970


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[PMID]:28981578
[Au] Autor:Fry SC
[Ad] Endereço:The Edinburgh Cell Wall Group, Institute of Molecular Plant Sciences, The University of Edinburgh, Daniel Rutherford Building, The King's Buildings, Max Born Crescent, Edinburgh EH9 3BF, UK.
[Ti] Título:Potassium, not lepidimoide, is the principal 'allelochemical' of cress-seed exudate that promotes amaranth hypocotyl elongation.
[So] Source:Ann Bot;120(4):511-520, 2017 Oct 17.
[Is] ISSN:1095-8290
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Background and Aims: Imbibed cress ( Lepidium sativum L.) seeds exude 'allelochemicals' that promote excessive hypocotyl elongation and inhibit root growth in neighbouring competitors, e.g. amaranth ( Amaranthus caudatus L.) seedlings. The major hypocotyl promoter has recently been shown not to be the previously suggested acidic disaccharide, lepidimoic acid (LMA), a fragment of the pectic polysaccharide domain rhamnogalacturonan-I. The nature of the hypocotyl promoter has now been re-assessed. Methods: Low-molecular weight cress-seed exudate (LCSE) was fractionated by high-voltage electrophoresis, and components with different charge:mass ratios were tested for effects on dark-grown amaranth seedlings. Further samples of LCSE were size-fractionated by gel permeation chromatography, and active fractions were analysed electrophoretically. Key Results: The LCSE strongly promoted amaranth hypocotyl elongation. The active principle was hydrophilic and, unlike LMA, stable to hot acid. After electrophoresis at pH 6·5, the only fractions that strongly promoted hypocotyl elongation were those with a very high positive charge:mass ratio, migrating towards the cathode 3-4 times faster than glucosamine. Among numerous naturally occurring cations tested, the only one with such a high mobility was potassium. K + was present in LCSE at approx. 4 m m , and pure KCl (1-10 m m ) strongly promoted amaranth hypocotyl elongation. No other cation tested (including Na + , spermidine and putrescine) had this effect. The peak of bioactivity from a gel permeation chromatography column exactly coincided with the peak of K + . Conclusions: The major 'allelopathic' substance present in cress-seed exudate that stimulates hypocotyl elongation in neighbouring seedlings is the inorganic cation, K + , not the oligosaccharin LMA.
[Mh] Termos MeSH primário: Amaranthus/crescimento & desenvolvimento
Dissacarídeos/fisiologia
Exsudatos e Transudatos/fisiologia
Hipocótilo/crescimento & desenvolvimento
Lepidium sativum/fisiologia
Potássio/fisiologia
Sementes/metabolismo
[Mh] Termos MeSH secundário: Amaranthus/metabolismo
Cromatografia em Gel
Eletroforese/métodos
Exsudatos e Transudatos/química
Hipocótilo/metabolismo
Lepidium sativum/metabolismo
Sementes/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Disaccharides); 145039-76-5 (lepidimoide); RWP5GA015D (Potassium)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171109
[Lr] Data última revisão:
171109
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171006
[St] Status:MEDLINE
[do] DOI:10.1093/aob/mcx081


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[PMID]:28697431
[Au] Autor:Pinho IA; Lopes DV; Martins RC; Quina MJ
[Ad] Endereço:CIEPQPF-Research Centre on Chemical Process Engineering and Forest Products, Department of Chemical Engineering, University of Coimbra, Portugal.
[Ti] Título:Phytotoxicity assessment of olive mill solid wastes and the influence of phenolic compounds.
[So] Source:Chemosphere;185:258-267, 2017 Oct.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The main objective of this work is to evaluate the phytotoxicity of olive mill solid wastes (OMW) produced in two different centrifugation technologies and also the toxicity associated with specific phenolic compounds. Two samples of waste were collected in two-phase (2P-OMW) and three-phase (3P-OMW) centrifugation olive oil production processes, and cress bioassays with Lepidium sativum L. were employed to evaluate phytotoxicity. Although both OMW have similar total phenolic content (TPh), results confirmed that 2P-OMW is more phytotoxic than 3P-OMW. When extracts from 2P-OMW at liquid to solid ratio of 10 L kg were applied none of the seeds germinated, i.e. germination index (GI) was 0%, while for 3P-OMW GI was 94.3%. Growth tests in soil and mixtures with OMW also led to more favorable results for 3P-OMW, whereas worse results than those obtained in the control experiments were observed. In order to discriminate the individual influence of eleven phenolic compounds, gallic acid, protocatechuic acid, cinnamic acid, syringic acid, 3,4,5-trimethoxybenzoic acid, 4-hydroxybenzoic acid, vanillic acid, p-coumaric acid, caffeic acid, veratric acid and phenol were tested in the concentration range of 5-500 mg L . Results showed that cinnamic acid is the most phytotoxic, with EC of 60 mg L , which is related with its hydrophobicity. Moreover, increasing -OH and -OCH groups in these molecules seem to reduce phytotoxicity. Tests with a mixture of six phenolic compounds demonstrated there are neither synergistic nor additive effects. The phytotoxicity appears to be determined by the presence of the most lipophilic phenolic molecule.
[Mh] Termos MeSH primário: Resíduos Industriais/análise
Lepidium sativum/efeitos dos fármacos
Olea/química
Fenóis
Resíduos Sólidos
[Mh] Termos MeSH secundário: Centrifugação
Cinamatos/análise
Cinamatos/farmacologia
Germinação/efeitos dos fármacos
Interações Hidrofóbicas e Hidrofílicas
Lepidium sativum/crescimento & desenvolvimento
Fenóis/análise
Fenóis/química
Fenóis/farmacologia
Sementes/efeitos dos fármacos
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cinnamates); 0 (Industrial Waste); 0 (Phenols); 0 (Solid Waste); U14A832J8D (cinnamic acid)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170712
[St] Status:MEDLINE


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[PMID]:28386894
[Au] Autor:Smolinska B; Leszczynska J
[Ad] Endereço:Department of Biotechnology and Food Sciences, Institute of General Food Chemistry, Lodz University of Technology, 4/10 Stefanowskiego Str, 90-924, Lodz, Poland. beata.smolinska@p.lodz.pl.
[Ti] Título:Photosynthetic pigments and peroxidase activity of Lepidium sativum L. during assisted Hg phytoextraction.
[So] Source:Environ Sci Pollut Res Int;24(15):13384-13393, 2017 May.
[Is] ISSN:1614-7499
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:The study was conducted to evaluate metabolic answer of Lepidium sativum L. on Hg, compost, and citric acid during assisted phytoextraction. The chlorophyll a and b contents, total carotenoids, and activity of peroxidase were determined in plants exposed to Hg and soil amendments. Hg accumulation in plant shoots was also investigated. The pot experiments were provided in soil artificially contaminated by Hg and/or supplemented with compost and citric acid. Hg concentration in plant shoots and soil substrates was determined by cold vapor atomic absorption spectroscopy (CV-AAS) method after acid mineralization. The plant photosynthetic pigments and peroxidase activity were measured by standard spectrophotometric methods. The study shows that L. sativum L. accumulated Hg in its aerial tissues. An increase in Hg accumulation was noticed when soil was supplemented with compost and citric acid. Increasing Hg concentration in plant shoots was correlated with enhanced activation of peroxidase activity and changes in total carotenoid concentration. Combined use of compost and citric acid also decreased the chlorophyll a and b contents in plant leaves. Presented study reveals that L. sativum L. is capable of tolerating Hg and its use during phytoextraction assisted by combined use of compost and citric acid lead to decreasing soil contamination by Hg.
[Mh] Termos MeSH primário: Lepidium sativum/metabolismo
Poluentes do Solo
[Mh] Termos MeSH secundário: Biodegradação Ambiental
Clorofila/análogos & derivados
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Soil Pollutants); 1406-65-1 (Chlorophyll); 22309-13-3 (chlorophyll a'); YF5Q9EJC8Y (chlorophyll a)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170605
[Lr] Data última revisão:
170605
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170408
[St] Status:MEDLINE
[do] DOI:10.1007/s11356-017-8951-3


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[PMID]:28262313
[Au] Autor:Emhofer L; Himmelsbach M; Buchberger W; Klampfl CW
[Ad] Endereço:Institute of Analytical Chemistry, Johannes Kepler University Linz, Altenberger Strasse 69, 4040 Linz, Austria. Electronic address: lisa.emhofer@jku.at.
[Ti] Título:High-performance liquid chromatography - mass spectrometry analysis of the parent drugs and their metabolites in extracts from cress (Lepidium sativum) grown hydroponically in water containing four non-steroidal anti-inflammatory drugs.
[So] Source:J Chromatogr A;1491:137-144, 2017 Mar 31.
[Is] ISSN:1873-3778
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:In this paper the metabolism of four non-steroidal anti-inflammatory drugs, (ketoprofen, mefenamic acid, naproxen, and diclofenac) by cress (Lepidium sativum) is described. Cress was cultivated hydroponically in water spiked with the parent drugs at levels ranging from 0.01mgL to 1mgL . Employing an approach based on the analysis of the plant extracts by HPLC coupled either with quadrupole-time-of-flight mass spectrometry, or Orbitrap MS or triple quadrupole (QqQ) MS allowed the identification of twenty substances (sixteen metabolites and four parent drugs). Metabolites were formed from the parent drug by hydroxylation or conjugation with polar molecules such as glucose, small organic acids or amino acids. Introducing a pre-concentration step employing solid-phase extraction and using HPLC-QqQ/MS in the multiple reaction monitoring mode enabled the positive detection of 11 of the proposed metabolites next to the four parent components even in plants grown in a 0.01mgL solution of the tested drugs, which is close to the conditions in real reclaimed waters.
[Mh] Termos MeSH primário: Anti-Inflamatórios não Esteroides
Cromatografia Líquida de Alta Pressão/métodos
Lepidium sativum/química
Espectrometria de Massas/métodos
Extratos Vegetais/química
Poluentes Químicos da Água
[Mh] Termos MeSH secundário: Anti-Inflamatórios não Esteroides/análise
Anti-Inflamatórios não Esteroides/metabolismo
Poluentes Químicos da Água/análise
Poluentes Químicos da Água/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents, Non-Steroidal); 0 (Plant Extracts); 0 (Water Pollutants, Chemical)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170516
[Lr] Data última revisão:
170516
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170307
[St] Status:MEDLINE


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[PMID]:28238907
[Au] Autor:Rani D; Ahuja M
[Ad] Endereço:Drug Delivery Research Laboratory, Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science & Technology, Hisar 125001 (Haryana), India.
[Ti] Título:Carboxymethylation of Lepidium sativum polyuronide, its characterization and evaluation as a nanometric carrier.
[So] Source:Int J Biol Macromol;99:233-240, 2017 Jun.
[Is] ISSN:1879-0003
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Carboxymethylation of Lepidium sativum polyuronide was carried out to improve its functionality. Carboxymethyl modification was accomplished by reacting it with monochloroacetic acid under alkaline conditions, which yielded a product with degree of carboxymethyl substitution of 1.75. The results of characterization studies revealed that carboxymethylation of L. sativum polyuronide improves its flow property, changes compression behavior from elastic to plastic, diminishes its viscosity and swelling, and increases its crystallinity. The interaction between the anionic carboxymethyl lepidium polyuronide and Mg ions was utilized to prepare ionically gelled nanoparticles employing ofloxacin as a model drug. A selected nanoparticulate formulation prepared by interaction between solutions of ofloxacin (0.1%, w/v) containing carboxymethyl lepidium polyuronide (0.15%, w/v) and magnesium chloride (0.05%, w/v) had particle size of 405nm and drug entrapment of 90.41%. On comparative evaluation, no significant difference was observed between the antibacterial activity of selected nanoformulation and conventional aqueous solution of ofloxacin. Further, the nanoparticulate formulation was observed to sustain the release of ofloxacin with 97% of the drug getting released over 12h. The release of ofloxacin from nanoformulation was found to follow first order kinetics with the mechanism of release being erosion of polymer matrix.
[Mh] Termos MeSH primário: Portadores de Fármacos/química
Lepidium sativum/química
Nanopartículas/química
Ácidos Urônicos/química
[Mh] Termos MeSH secundário: Liberação Controlada de Fármacos
Metilação
Ofloxacino/química
Tamanho da Partícula
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Drug Carriers); 0 (Uronic Acids); 0 (traumacel); A4P49JAZ9H (Ofloxacin)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170424
[Lr] Data última revisão:
170424
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170228
[St] Status:MEDLINE


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[PMID]:27842277
[Au] Autor:Koltowski M; Charmas B; Skubiszewska-Zieba J; Oleszczuk P
[Ad] Endereço:Department of Environmental Chemistry, Faculty of Chemistry, Maria Curie-Sklodowska University, Pl. M. Curie-Sklodowskiej 3, 20-031 Lublin, Poland.
[Ti] Título:Effect of biochar activation by different methods on toxicity of soil contaminated by industrial activity.
[So] Source:Ecotoxicol Environ Saf;136:119-125, 2017 Feb.
[Is] ISSN:1090-2414
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The objective of the study was to determine the effect of various methods of biochar activation on the ecotoxicity of soils with various properties and with various content and origin of contaminants. The biochar produced from willow (at 700°C) was activated by 1) microwaves (in a microwave reactor under an atmosphere of water vapour), 2) carbon dioxide (in the quartz fluidized bed reactor) and 3) superheated steam (in the quartz fluidized bed reactor). Three different soils were collected from industrial areas. The soils were mixed with biochar and activated biochars at the dose of 5% and ecotoxicological parameters of mixture was evaluated using two solid phase test - Phytotoxkit F (Lepidium sativum) and Collembolan test (Folsomia candida) and one liquid phase test - Microtox® (Vibrio fischeri). Biochar activation had both positive and negative impacts, depending on the activation method, kind of bioassay and kind of soil. Generally, biochar activated by microwaves increased the effectiveness of ecotoxicity reduction relative to non-activated biochars. Whereas, biochar activated with CO most often cause a negative effect manifested by deterioration or as a lack of improvement in relation to non-activated biochar or to non-amended soil. It was also demonstrated that the increase of biochar specific surface area caused a significant reduction of toxicity of water leachates from the studied soils. Effectiveness of the reduction of leachate toxicity was weakened in the presence of dissolved organic carbon in the soil.
[Mh] Termos MeSH primário: Aliivibrio fischeri/efeitos dos fármacos
Artrópodes/efeitos dos fármacos
Carvão Vegetal/química
Ecotoxicologia/métodos
Lepidium sativum/efeitos dos fármacos
Poluentes do Solo/toxicidade
[Mh] Termos MeSH secundário: Animais
Dióxido de Carbono/química
Temperatura Alta
Micro-Ondas
Polônia
Salix/química
Vapor
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Soil Pollutants); 0 (Steam); 0 (biochar); 142M471B3J (Carbon Dioxide); 16291-96-6 (Charcoal)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170119
[Lr] Data última revisão:
170119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161115
[St] Status:MEDLINE


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[PMID]:27419261
[Au] Autor:Urbaniak M; Zielinski M; Wyrwicka A
[Ad] Endereço:a European Regional Centre for Ecohydrology, Polish Academy of Sciences , Lodz , Poland.
[Ti] Título:The influence of the Cucurbitaceae on mitigating the phytotoxicity and PCDD/PCDF content of soil amended with sewage sludge.
[So] Source:Int J Phytoremediation;19(3):207-213, 2017 Mar 04.
[Is] ISSN:1549-7879
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The study evaluates the impact of sewage sludge on OECD - Organization for Economic Cooperation and Development and vegetable soil phytotoxicity, measured using three test species: Lepidium sativum, Sinapis alba and Sorghum saccharatum, and total and TEQ PCDD/PCDF (toxic equivalency polychlorinated dibenzo-p-dioxins/polychlorinated dibenzofurans) soil concentration, measured using HRGC/HRMS - High Resolution Gas Chromatography/High Resolution Mass Spectrometry. It also evaluates the effect of zucchini and cucumber cultivation during 5-weeks period on mitigating these parameters. The application of 3, 9 and 18 t/ha of sewage sludge gradually increases the phytotoxicity of both OECD and vegetable soil. In the case of OECD soil, the highest roots growth inhibitions were observed for S. alba (73%, 86% and 87%, respectively) and the lowest for S. saccharatum (7%, 59% and 70%), while in vegetable soil inhibitions were averagely 25% lower. Sludge application also led to a 38% (3 t/ha), 169% (9 t/ha) and 506% (18 t/ha) increase in PCDD/PCDF concentration, and the TEQs were augmented by 15%, 159% and 251%. Both soil phytotoxicity and total and TEQ PCDD/PCDF concentrations were diminished as a result of zucchini and cucumber cultivation. The maximum reduction of soil phytotoxicity (83%) was observed as an effect of cucumber cultivation, while zucchini was 11% less effective. Zucchini, in turn, was more efficient in PCDD/PCDF removal (37% reduction), followed by cucumber (24%). Such differences were not observed in the case of TEQ reductions (68% and 66% for zucchini and cucumber cultivation, respectively).
[Mh] Termos MeSH primário: Cucumis sativus/metabolismo
Cucurbita/metabolismo
Dibenzofuranos Policlorados/metabolismo
Dibenzodioxinas Policloradas/metabolismo
Esgotos/análise
Poluentes do Solo/metabolismo
[Mh] Termos MeSH secundário: Biodegradação Ambiental
Dibenzofuranos Policlorados/toxicidade
Lepidium sativum/efeitos dos fármacos
Dibenzodioxinas Policloradas/toxicidade
Sinapis/efeitos dos fármacos
Solo/química
Poluentes do Solo/toxicidade
Sorghum/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Dibenzofurans, Polychlorinated); 0 (Polychlorinated Dibenzodioxins); 0 (Sewage); 0 (Soil); 0 (Soil Pollutants)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160716
[St] Status:MEDLINE
[do] DOI:10.1080/15226514.2016.1207606


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[PMID]:27912738
[Au] Autor:Raish M; Ahmad A; Alkharfy KM; Ahamad SR; Mohsin K; Al-Jenoobi FI; Al-Mohizea AM; Ansari MA
[Ad] Endereço:Department of Pharmaceutics, College of Pharmacy, King Saud University, PO Box 2457, Riyadh, 11451, Saudi Arabia. mraish@ksu.edu.sa.
[Ti] Título:Hepatoprotective activity of Lepidium sativum seeds against D-galactosamine/lipopolysaccharide induced hepatotoxicity in animal model.
[So] Source:BMC Complement Altern Med;16(1):501, 2016 Dec 03.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Fulminant hepatic failure (FHF) is clinical syndrome with very poor prognosis and high mortality there is urgent need for the development of safe and non-toxic hepatoprotective agents for the adequate management of hepatitis. Hepatoprotective effect of the Lepidium sativum ethanolic extract (LSEE) was assessed by D-galactosamine-induced/lipopolysaccharide (400 mg/kg and 30 µg/kg) liver damage model in rats. METHODS: Hepatoprotective activity of LSEE (150 and 300 mg/kg) and silymarin on D-GalN/LPS induced FHF in rat was assessed using several liver function enzyme parameters. Antioxidant properties as antioxidant stress enzymes were assessed in hepatic Liver as well as mRNA expression of cytokines genes such as TNF-α, IL-6, and IL-10 and stress related genes iNOS and HO-1 were determined by RT-PCR. Protein expression of apoptotic genes were evaluated through western blot. MPO and NF-κB DNA-binding activity was analyzed by ELISA. The magnitude of hepatic impairment was investigated through histopathological evaluation. RESULTS: Marked amelioration of hepatic injuries by attenuation of serum and lipid peroxidation has been observed as comparable with silymarin (25 mg/kg p.o). D-GalN/LPS induced significant decrease in oxidative stress markers protein level, and albumin. LSEE significantly down-regulated the D-GalN/LPS induced pro-inflammatory cytokines TNFα and IL-6 mRNA expression in dose dependent fashion about 0.47 and 0.26 fold and up-regulates the IL-10 by 1.9 and 2.8 fold, respectively. While encourages hepatoprotective activity by down-regulating mRNA expression of iNOS and HO-1. MPO activity and NF-κB DNA-binding effect significantly increased and was mitigated by LSEE in a dose-dependent style as paralleled with silymarin. CONCLUSION: Our data suggests that pretreatment of LSEE down regulates the caspase 3 and up-regulates the BCl protein expression. The above findings revealed that Lepidium sativum has significant hepatoprotective activity.
[Mh] Termos MeSH primário: Doença Hepática Induzida por Substâncias e Drogas/prevenção & controle
Lepidium sativum
Falência Hepática Aguda/prevenção & controle
Fígado/efeitos dos fármacos
Preparações de Plantas/uso terapêutico
Substâncias Protetoras/farmacologia
Sementes
[Mh] Termos MeSH secundário: Animais
Modelos Animais de Doenças
Galactosamina
Lipopolissacarídeos
Falência Hepática Aguda/induzido quimicamente
Testes de Função Hepática
Masculino
Fitoterapia
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Lipopolysaccharides); 0 (Plant Preparations); 0 (Protective Agents); 7535-00-4 (Galactosamine)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161204
[St] Status:MEDLINE



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