Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.162 [Categoria DeCS]
Referências encontradas : 96 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 10 ir para página                        

  1 / 96 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28623915
[Au] Autor:Zhou X; Rong Q; Xu M; Zhang Y; Dong Q; Xiao Y; Liu Q; Chen H; Yang X; Yu K; Li Y; Zhao L; Ye G; Shi F; Lv C
[Ti] Título:Safety pharmacology and subchronic toxicity of jinqing granules in rats.
[So] Source:BMC Vet Res;13(1):179, 2017 Jun 17.
[Is] ISSN:1746-6148
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Jinqing granules which are made of a mixture extract that contains Radix Tinosporae and Canarii fructus in proportions according to a longstanding formula have a good effect on the prevention and treatment of gastric ulcer disease. It has not been through safety through systematic toxicological studies, however. To provide basis for clinical application, we performed safety pharmacology and subchronic toxicity experiments in specific pathogen-free Sprague-Dawley rats. RESULTS: In safety pharmacology experiments, Jinqing granules had no evident adverse effects on the central nervous, cardiovascular, or respiratory systems. In subchronic toxicity study, 2-8 g/kg of Jinqing granules induced no evident adverse effects on Clinical signs, body weight changes, food and water intake, death daily, indicators of urine, hematological assay, serum biochemistry, organ coefficient and histopathological examination. However, the 16 g/kg dose was associated with slightly slowed weight growth, decreased number of sperm in seminiferous tubules and increased values of serum aspartate aminotransferase and bilirubin. During the 30-day feeding test, 3 rats that received the 16 g/kg dose died, but the deaths were most likely due to trauma of oral gavage, not to drug toxicity. CONCLUSION: Jinqing granules given to Sprague-Dawley rats orally for 30 days at a dose of 8 g/kg or less appears safe, but higher doses were not proven safe. The significance of these observations with respect to animal usage of Jinqing granules deserves thorough investigation.
[Mh] Termos MeSH primário: Medicamentos de Ervas Chinesas/farmacologia
[Mh] Termos MeSH secundário: Animais
Burseraceae/química
Medicamentos de Ervas Chinesas/toxicidade
Feminino
Masculino
Ratos
Ratos Sprague-Dawley
Tinospora/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Drugs, Chinese Herbal); 0 (jinqing)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171107
[Lr] Data última revisão:
171107
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170619
[St] Status:MEDLINE
[do] DOI:10.1186/s12917-017-1095-3


  2 / 96 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28554634
[Au] Autor:Tee LH; Yang B; Tey BT; Chan ES; Azlan A; Ismail A; Sun J; Lau CY; Palanisamy UD; Ramanan RN; Prasad KN
[Ad] Endereço:School of Engineering, Advanced Engineering Platform, Monash University Malaysia, Jalan Lagoon Selatan, 47500 Bandar Sunway, Selangor, Malaysia.
[Ti] Título:Valorization of Dacryodes rostrata fruit through the characterization of its oil.
[So] Source:Food Chem;235:257-264, 2017 Nov 15.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Dacryodes rostrata (kembayau) is an important food and oil resource for local communities in Borneo, but it is not commonly known to wider community. The objective of this work is to valorize kembayau fruit by evaluating the characteristics of the oil from the fruit. In this study, the physicochemical characteristics and the lipophilic essential nutrient; the fatty acid composition, vitamin E and beta-carotene content of oils obtained from the peel, pulp and seeds of kembayau fruits were studied. The pulp of the kembayau fruit contained highest proportion of oil, followed by peel and seed. Kembayau fruit contained vitamin E and had trace amount of beta-carotene. Besides, kembayau fruit oils were not toxic to BRL3A cells, provided hepatoprotection and reversed lipid peroxidation in paracetamol-induced toxicity. Our results suggest that kembayau can be a potential source for cooking oil as the physicochemical characteristics are comparable with commercial source such as oil palm.
[Mh] Termos MeSH primário: Burseraceae/química
Óleos Vegetais/química
[Mh] Termos MeSH secundário: Ácidos Graxos
Frutas
Vitamina E
beta Caroteno
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fatty Acids); 0 (Plant Oils); 01YAE03M7J (beta Carotene); 1406-18-4 (Vitamin E)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170808
[Lr] Data última revisão:
170808
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170531
[St] Status:MEDLINE


  3 / 96 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28212341
[Au] Autor:Ferreira RG; Silva Júnior WF; Veiga Junior VF; Lima ÁA; Lima ES
[Ad] Endereço:Higher Normal School, University of the State of Amazonas, Av. Djalma Batista 69050-010, Brazil. rgsilva@uea.edu.br.
[Ti] Título:Physicochemical Characterization and Biological Activities of the Triterpenic Mixture α,ß-Amyrenone.
[So] Source:Molecules;22(2), 2017 Feb 16.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:α-Amyrenone and ß-amyrenone are triterpenoid isomers that occur naturally in very low concentrations in several oleoresins from Brazilian Amazon species of (Burseraceae). This mixture can also be synthesized by oxidation of α,ß-amyrins, obtained as major compounds from the same oleoresins. Using a very simple, high yield procedure, and using a readily commercially available mixture of α,ß-amyrins as substrate, the binary compound α,ß-amyrenone was synthesized and submitted to physico-chemical characterization using different techniques such as high-performance liquid chromatography, nuclear magnetic resonance (¹H and C), mass spectrometry, scanning electron microscopy, differential scanning calorimetry, thermogravimetry and derivative thermogravimetry, and Fourier transform infrared spectroscopy (FTIR). Biological effects were also evaluated by studying the inhibition of enzymes involved in the carbohydrate and lipid absorption process, such as α-amylase, α-glucosidase, lipase, and their inhibitory concentration values of 50% of activity (IC ) were also determined. α,ß-Amyrenone significantly inhibited α-glucosidase (96.5% ± 0.52%) at a concentration of 1.6 g/mL. α,ß-Amyrenone, at a concentration of 100 µg/mL, showed an inhibition rate on lipase with an IC value of 82.99% ± 1.51%. The substances have thus shown in vitro inhibitory effects on the enzymes lipase, α-glucosidase, and α-amylase. These findings demonstrate the potential of α,ß-amyrenone for the development of drugs in the treatment of chronic metabolic diseases.
[Mh] Termos MeSH primário: Triterpenos/química
Triterpenos/farmacologia
[Mh] Termos MeSH secundário: Burseraceae/química
Varredura Diferencial de Calorimetria
Cromatografia Líquida de Alta Pressão
Inibidores Enzimáticos/química
Inibidores Enzimáticos/farmacologia
Oxirredução
Termogravimetria
Difração de Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Enzyme Inhibitors); 0 (Triterpenes); 638-96-0 (alpha-amyrenone)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170509
[Lr] Data última revisão:
170509
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170218
[St] Status:MEDLINE


  4 / 96 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28143669
[Au] Autor:Albino RC; Oliveira PC; Prosdocimi F; da Silva OF; Bizzo HR; Gama PE; Sakuragui CM; Furtado C; de Oliveira DR
[Ad] Endereço:Faculty of Pharmacy, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-590, RJ, Brazil.
[Ti] Título:Oxidation of monoterpenes in Protium heptaphyllum oleoresins.
[So] Source:Phytochemistry;136:141-146, 2017 Apr.
[Is] ISSN:1873-3700
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Protium heptaphyllum (Burseraceae) oleoresins are rich in volatile monoterpenes, exhibiting a chemical composition that can be strongly altered with time. The present work aimed to discuss the temporal change of the volatile composition of these oleoresins, and search for related supporting evidence. Samples of P. heptaphyllum oleoresin were collected separately for fresh (n = 10) and aged (n = 8) oleoresins, with the essential oils obtained by hydrodistillation analyzed by GC-FID and GC-MS. Fresh oleoresins were characterized by a high content of terpinolene (28.2-69.7%), whereas aged ones contained large amounts of p-cymene (18.7-43.0%) and p-cymen-8-ol (8.2-31.8%). Multivariate analyses were performed based on the yield and major essential oil components to clearly demonstrate the existence of two subsets (fresh and aged oleoresins). In addition, an analysis of the partial genome sequencing of the species was carried out, producing the largest amount of data for the genus Protium. Subsequently, were searched for nucleotide sequences responsible for the enzymes involved in the biosynthesis of monoterpenes. Two hypotheses were formulated to understand the oxidation process during aging of the oleoresins: (i) a natural chemical oxidation of terpenes and (ii) an oxidation catalyzed by enzymes produced by microorganisms associated with the plant. The results suggested that terpinolene was most likely oxidized to p-cymene, which, in turn, was oxidized into p-cymen-8-ol during natural aging of the exudate due to abiotic factors.
[Mh] Termos MeSH primário: Burseraceae/química
Monoterpenos/isolamento & purificação
Extratos Vegetais/química
[Mh] Termos MeSH secundário: Cromatografia Gasosa-Espectrometria de Massas
Monoterpenos/química
Monoterpenos/metabolismo
Óleos Voláteis/química
Oxirredução
Terpenos/análise
Terpenos/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Monoterpenes); 0 (Oils, Volatile); 0 (Plant Extracts); 0 (Terpenes); 0 (oleoresins); 1G1C8T1N7Q (4-cymene); N9830X5KSL (terpinolene)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170321
[Lr] Data última revisão:
170321
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170202
[St] Status:MEDLINE


  5 / 96 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27525508
[Au] Autor:Carvalho KM; de Melo TS; de Melo KM; Quinderé AL; de Oliveira FT; Viana AF; Nunes PI; Quetz JD; Viana DA; da Silva AA; Havt A; Fonseca SG; Chaves MH; Rao VS; Santos FA
[Ad] Endereço:Post-Graduate Program in Medical Sciences, Faculty of Medicine, Federal University of Ceará, Fortaleza, Ceará, Brazil.
[Ti] Título:Amyrins from Protium heptaphyllum Reduce High-Fat Diet-Induced Obesity in Mice via Modulation of Enzymatic, Hormonal And Inflammatory Responses.
[So] Source:Planta Med;83(3-04):285-291, 2017 Feb.
[Is] ISSN:1439-0221
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Obesity remains a global problem. In search of phytochemicals that have antiobesity potential, this study evaluated -amyrin, a triterpenoid mixture from , on high-fat diet-induced obesity in mice. Groups of mice (n = 8) were fed a normal diet or a high-fat diet, and were orally treated or not treated with either -amyrin (10 or 20 mg/kg) or sibutramine (10 mg/kg) for 15 weeks. Variables measured at termination were body weight, visceral fat accumulation, adipocyte surface area, peroxisome proliferator-activated receptor gamma, and lipoprotein lipase expressions in adipose tissue, the levels of plasma glucose and insulin, the satiety hormones ghrelin and leptin, the digestive enzymes amylase and lipase, and the inflammatory mediators TNF- , interleukin-6, and MCP-1. Results showed that -amyrin treatment resulted in lower high-fat diet-induced increases in body weight, visceral fat content, adipocyte surface area, peroxisome proliferator-activated receptor gamma, and lipoprotein lipase expressions, and blood glucose and insulin levels. Additionally, the markedly elevated leptin and decreased ghrelin levels seen in the high-fat diet-fed control mice were significantly modulated by -amyrin treatment. Furthermore, -amyrin decreased serum TNF- and MCP-1. These results suggest that -amyrin could be beneficial in reducing high-fat diet-induced obesity and associated disorders via modulation of enzymatic, hormonal, and inflammatory responses.
[Mh] Termos MeSH primário: Fármacos Antiobesidade/farmacologia
Obesidade/tratamento farmacológico
Ácido Oleanólico/análogos & derivados
[Mh] Termos MeSH secundário: Gordura Abdominal/efeitos dos fármacos
Adipócitos/citologia
Adipócitos/efeitos dos fármacos
Tecido Adiposo/efeitos dos fármacos
Tecido Adiposo/metabolismo
Tecido Adiposo Branco/efeitos dos fármacos
Animais
Glicemia/metabolismo
Peso Corporal/efeitos dos fármacos
Burseraceae/química
Ciclobutanos/farmacologia
Dieta Hiperlipídica
Grelina/sangue
Insulina/sangue
Leptina/sangue
Lipídeos/sangue
Lipase Lipoproteica/metabolismo
Masculino
Camundongos
Obesidade/sangue
Obesidade/etiologia
Ácido Oleanólico/química
Ácido Oleanólico/isolamento & purificação
Ácido Oleanólico/farmacologia
PPAR gama/metabolismo
Fitoterapia
Resistina/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Obesity Agents); 0 (Blood Glucose); 0 (Cyclobutanes); 0 (Ghrelin); 0 (Insulin); 0 (Leptin); 0 (Lipids); 0 (PPAR gamma); 0 (Resistin); 6SMK8R7TGJ (Oleanolic Acid); EC 3.1.1.34 (Lipoprotein Lipase); KM8353IPSO (amyrin); WV5EC51866 (sibutramine)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170621
[Lr] Data última revisão:
170621
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160816
[St] Status:MEDLINE
[do] DOI:10.1055/s-0042-114222


  6 / 96 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28852729
[Au] Autor:Okolo CA; Ejere VC; Chukwuka CO; Ezeigbo II; Nwibo DD; Okorie AN
[Ad] Endereço:Physiology Unit, Department of Zoology and Environmental Biology, Faculty of Biological Sciences, University of Nigeria, Nsukka, Enugu State. 410001, Nigeria.
[Ti] Título:HEXANE EXTRACT OF FRUITS POSSESSES ANTI-DIABETIC AND HYPOLIPIDAEMIC POTENTIALS IN ALLOXAN DIABETES OF RATS.
[So] Source:Afr J Tradit Complement Altern Med;13(4):132-144, 2016.
[Is] ISSN:2505-0044
[Cp] País de publicação:Nigeria
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The fruit extract of , the African pear or plum, a tree indigenous to the humid tropics has been used for managing wounds, skin diseases, sickle cell anaemia, dysentery and fever in some African nations. In South Eastern Nigeria, 'herbal doctors' include its marshed fruit in decoctions administered to diabetic patients. However no scientific substantiation of their claim and use exist in literature. Hence, the need to evaluate the antidiabetic and hypolipidaemic activity of hexane extracts of D. edulis fruit in alloxanised animal model. MATERIALS AND METHODS: Sub-toxic doses between 400 and 1600mg/kg were orally administered sub-chronically to alloxan-induced diabetic rats for 15 days and compared to glibenclamide (2.5mg/kg). The glycaemia levels, body weights, lipid profile, blood urea, creatinine and liver enzyme levels were measured. Basic histology of the pancreatic tissue was also performed to examine the effects on the pancreas as possible mechanistic lead. RESULTS: Oral acute dosing of hexane extract decreased blood glucose levels, while sub-chronic treatment of the extract down-regulated significantly hyperglycaemia, total cholesterol, triglycerides, LDL-C, ALT and ALP levels. However, the HDL-C levels increased significantly. Histopathological examination of the pancreatic tissues after sub-chronic treatment showed that glibenclamide and the highest dose of the extract 1600mg/kg restored the afore-damaged pancreatic ß-cell architecture. CONCLUSION: Our findings portend that D. edulis hexane fruit extract possesses hypoglycaemic and hypolipidaemic activities as well as restoration of the pancreatic architecture without any obvious untoward hepatic damages, suggesting that its use in the management of the diabetes may be valid. = , DEnH = n-hexane fruit extract, B.wt. = Body weight, Per os = Oral administration, NC = normal control, DC =Diabetic control, SC = Standard control, LDL-C = low density lipoprotein cholesterol, HDL-C = High density lipoprotein cholesterol, TG = Triglyceride, TC = Total cholesterol.
[Mh] Termos MeSH primário: Burseraceae/química
Diabetes Mellitus Experimental/tratamento farmacológico
Hipoglicemiantes/administração & dosagem
Hipolipemiantes/administração & dosagem
Extratos Vegetais/administração & dosagem
[Mh] Termos MeSH secundário: Aloxano/efeitos adversos
Animais
Glicemia/metabolismo
Colesterol/metabolismo
Diabetes Mellitus Experimental/metabolismo
Feminino
Frutas/química
Hexanos/química
Seres Humanos
Masculino
Camundongos
Nigéria
Fitoterapia
Ratos
Triglicerídeos/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Blood Glucose); 0 (Hexanes); 0 (Hypoglycemic Agents); 0 (Hypolipidemic Agents); 0 (Plant Extracts); 0 (Triglycerides); 6SW5YHA5NG (Alloxan); 97C5T2UQ7J (Cholesterol)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170908
[Lr] Data última revisão:
170908
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170831
[St] Status:MEDLINE
[do] DOI:10.21010/ajtcam.v13i4.18


  7 / 96 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27706623
[Au] Autor:Cheng JL; Yin ZC; Mei ZQ; Wei CL; Chen HC; Wu XS; Fu JJ
[Ad] Endereço:Research Center for Preclinical Medicine, Southwest Medical University, Luzhou, Sichuan, China.
[Ti] Título:Development and significance of SCAR marker QG12-5 for Canarium album (Lour.) Raeusch by molecular cloning from improved RAPD amplification.
[So] Source:Genet Mol Res;15(3), 2016 Aug 26.
[Is] ISSN:1676-5680
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:Sequence-characterized amplified region (SCAR) is a valuable molecular marker for the genetic identification of any species. This marker is mainly derived from molecular cloning of random amplified polymorphic DNA (RAPD). We have previously reported the use of an improved RAPD technique for the genetic characterization of different samples of Canarium album (Lour.) Raeusch (C. album). In this study, DNA fragments were amplified using improved RAPD amplified from different samples of C. album. The amplified DNA fragment was excised, purified from an agarose gel and cloned into a pGM-T vector; subsequently, a positive clone, called QG12-5 was identified by PCR amplification and enzymatic digestion and sequenced by Sanger di-deoxy sequencing method. This clone was revealed consisting of 510 nucleotides of C. album. The SCAR marker QG12-5 was developed using specifically designed PCR primers and optimized PCR conditions. This SCAR marker expressed seven continuous "TATG" [(TATG)n] tandem repeats, which was found to characterize C. album. Subsequently, this novel SCAR marker was deposited in GenBank with accession No. KT359568. Therefore, we successfully developed a C. album-specific SCAR marker for the identification and authentication of different C. album species in this study.
[Mh] Termos MeSH primário: Burseraceae/genética
DNA de Plantas/genética
Marcadores Genéticos
Genoma de Planta
Técnica de Amplificação ao Acaso de DNA Polimórfico
[Mh] Termos MeSH secundário: Sequência de Bases
Clonagem Molecular
Primers do DNA/síntese química
Repetições Minissatélites
Plantas Medicinais
Reação em Cadeia da Polimerase
Análise de Sequência de DNA
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA Primers); 0 (DNA, Plant); 0 (Genetic Markers)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170224
[Lr] Data última revisão:
170224
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161006
[St] Status:MEDLINE
[do] DOI:10.4238/gmr.15038347


  8 / 96 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27318506
[Au] Autor:Peng LQ; Li Q; Chang YX; An M; Yang R; Tan Z; Hao J; Cao J; Xu JJ; Hu SS
[Ad] Endereço:College of Material Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 310036, China.
[Ti] Título:Determination of natural phenols in olive fruits by chitosan assisted matrix solid-phase dispersion microextraction and ultrahigh performance liquid chromatography with quadrupole time-of-flight tandem mass spectrometry.
[So] Source:J Chromatogr A;1456:68-76, 2016 Jul 22.
[Is] ISSN:1873-3778
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:A simple, efficient and low-cost method based on matrix solid-phase dispersion (MSPD) microextraction and ultrahigh-performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry (UHPLC-Q-TOF/MS) was developed for the determination of seven main natural phenols (gallic acid, hydroxytyrosol, methyl gallate, luteolin 7-O-ß-d-glucoside, rutin, ellagic acid and oleuropein) and other eleven compounds in olive fruits. The experimental conditions for the MSPD extraction, including the type of adsorbent, the amount of dispersing sorbent, the grinding time, and the type of elution solvent were investigated and optimized. The optimized parameters were determined to be that middle-molecular-weight chitosan was used as adsorbent, the amount of middle-molecular-weight chitosan was selected to be 25mg, the grinding time was chosen to be 60s, and methanol: water (6:4, v:v) was used as elution solvent. Compared with reported methods, the proposed method was more simple, rapid, and efficient. Moreover, this method required less extraction time and less amount of sample and solvent. The method showed good linearity (r(2)≥0.9909) for the seven analytes, with the limits of detection in the range of 69.6-358.4ng/g. And recoveries were above 80.06%. The methodology was successfully applied to the extraction and determination of seven phenolic compounds in olive fruits(Canarii fructus).
[Mh] Termos MeSH primário: Burseraceae/química
Quitosana/química
Fenóis/análise
[Mh] Termos MeSH secundário: Cromatografia Líquida de Alta Pressão
Frutas/química
Metanol
Microextração em Fase Sólida
Solventes
Espectrometria de Massas em Tandem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Phenols); 0 (Solvents); 9012-76-4 (Chitosan); Y4S76JWI15 (Methanol)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160620
[St] Status:MEDLINE


  9 / 96 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27246378
[Au] Autor:Jia YL; Zheng J; Yu F; Cai YX; Zhan XL; Wang HF; Chen QX
[Ad] Endereço:State Key Laboratory of Cellular Stress Biology, Key Laboratory of the Ministry of Education for Coastal and Wetland Ecosystems, School of Life Sciences, Xiamen University, Xiamen 361005, China.
[Ti] Título:Anti-tyrosinase kinetics and antibacterial process of caffeic acid N-nonyl ester in Chinese Olive (Canarium album) postharvest.
[So] Source:Int J Biol Macromol;91:486-95, 2016 Oct.
[Is] ISSN:1879-0003
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Enzymatic browning and bacterial putrefaction are mainly responsible for quality losses of Chinese Olive (Canarium album) postharvest and lead to very short shelf life on average. Screening anti-browning and anti-bacterial agents is important for preservation of Chinese Olive. Caffeic acid N-nonyl ester (C-9) and caffeic acid N- Heptyl ester (C-7) was synthesized as inhibitors of tyrosinase, which is a key enzyme in browning process. The compound of C-9 could inhibit the activity of tyrosinase strongly and its IC50 value was determined to be 37.5µM, while the compound of C-7 had no inhibitory ability. Kinetic analyses showed that compound of C-9 has been a reversible inhibitory mechanism below 50µM and been irreversible mechanisms above 50µM. For the reversible inhibitory mechanism, the values of inhibitory constants (KI and KIS) were determined to be 24.6 and 37.4µM, respectively. The results of Chinese Olive fruit postharvest showed that the compound of C-9 could effectively anti-browning and anti-bacterial putrefaction. In addition, this compound had strong antibacterial activities against Staphylococcus aureus, Escherichia coli, Bacillus subtilis and Salmonella. Therefore, C-9 could be a potential anti-browning and anti-bacterial reagent.
[Mh] Termos MeSH primário: Antibacterianos/química
Burseraceae
Ácidos Cafeicos/química
Reação de Maillard
Monofenol Mono-Oxigenase/antagonistas & inibidores
[Mh] Termos MeSH secundário: Antibacterianos/farmacologia
Bactérias/crescimento & desenvolvimento
Ácidos Cafeicos/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Caffeic Acids); EC 1.14.18.1 (Monophenol Monooxygenase)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170302
[Lr] Data última revisão:
170302
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160602
[St] Status:MEDLINE


  10 / 96 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
PubMed Central Texto completo
Texto completo
[PMID]:26822971
[Au] Autor:Basri DF; Alamin ZA; Chan KM
[Ad] Endereço:School of Diagnostic and Applied Health Sciences, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, Kuala Lumpur, 50300, Malaysia. dayang@ukm.edu.my.
[Ti] Título:Assessment of cytotoxicity and genotoxicity of stem bark extracts from Canarium odontophyllum Miq. (dabai) against HCT 116 human colorectal cancer cell line.
[So] Source:BMC Complement Altern Med;16:36, 2016 Jan 29.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Canarium odontophyllum Miq. is a plant species widely known as 'dabai' and can be vastly found in Sarawak. The aim of this study was to assess the cytotoxic and genotoxic effect of extracts from stem bark of C. odontophyllum against HCT 116 human colorectal cancer cell line. METHOD: The IC50 values of the aqueous, methanol, and acetone extracts against HCT 116 cells as well as the acetone extract against human colon fibroblast cell line CCD-18co were determined using the MTT assay. The concentration of the extracts ranged from 12.5 to 200 µg/ml at treatment time of 24, 48 and 72 h. Annexin V-FITC/PI labelling assay was employed to determine mode of HCT 116 cell death induced by acetone extract at 48 h. The DNA damage induced by the extract in HCT 116 cells was detected using alkaline comet assay at 30 min of IC10 and IC25 treatment. RESULTS: Acetone extract exhibited the highest cytotoxic effect against HCT 116 cells compared to methanol and aqueous extract at 24, 48 and 72 h. Despite no cytotoxic effect by acetone extract against CCD-18co cells at 24 and 48 h, however at 72 h, CCD-18co cells proliferated. Apoptosis assessment using Annexin V-FITC/PI labelling assay revealed that the primary cell death was via apoptosis after 48 h treatment. Low doses of acetone extract from stem bark of C. odontophyllum showed significant DNA damage in HCT 116 cells with tail moment of 6.187 ± 0.718 A.U and 7.877 ± 0.142 A.U, respectively. CONCLUSIONS: Acetone extract from stem bark of C. odontophyllum has high potential in the development of anticancer agent against HCT 116 cells with no cytotoxic effect against human colon fibroblast cells.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/farmacologia
Burseraceae/química
Mutagênicos/toxicidade
[Mh] Termos MeSH secundário: Antineoplásicos Fitogênicos/toxicidade
Morte Celular
Linhagem Celular
Neoplasias Colorretais/tratamento farmacológico
Células HCT116
Seres Humanos
Malásia
Casca de Planta/química
Extratos Vegetais/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Mutagens); 0 (Plant Extracts)
[Em] Mês de entrada:1609
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160130
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-016-1015-2



página 1 de 10 ir para página                        
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde