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[PMID]:29385990
[Au] Autor:Schoendorfer N; Sharp N; Seipel T; Schauss AG; Ahuja KDK
[Ad] Endereço:School of Medicine, University of Queensland, Herston, Australia.
[Ti] Título:Urox containing concentrated extracts of Crataeva nurvala stem bark, Equisetum arvense stem and Lindera aggregata root, in the treatment of symptoms of overactive bladder and urinary incontinence: a phase 2, randomised, double-blind placebo controlled trial.
[So] Source:BMC Complement Altern Med;18(1):42, 2018 Jan 31.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Storage lower urinary tract symptoms (LUTS) including overactive bladder (OAB) and urinary incontinence (UI) affect millions of people worldwide, significantly impacting quality of life. Plant based medicines have been documented both empirically and in emerging scientific research to have varying benefits in reducing bladder symptoms. We assessed the efficacy of Urox®, a proprietary combination of phytomedicine extracts including, Cratevox™ (Crataeva nurvala) stem bark, Equisetem arvense stem and Lindera aggregata root, in reducing symptoms of OAB and UI. METHODS: Efficacy of the herbal combination on a variety of bladder symptoms compared to an identical placebo, were documented in a randomised, double-blind, placebo controlled trial conducted at two primary care centres. Data were collected at baseline, 2, 4 and 8 weeks, with the primary outcome being self-reported urinary frequency. Statistical analysis included mixed effects ordered logistic regression with post hoc Holm's test to account for repeated measures, and included an intention-to-treat analysis. RESULTS: One hundred and fifty participants (59% female, aged; mean ± SD; 63.5 ± 13.1 years) took part in the study. At week 8, urinary day frequency was significantly lower (OR 0.01; 95%CI 0.01 to 0.02; p < 0.001) in response to treatment (mean ± SD; 7.69 ± 2.15/day) compared to placebo (10.95 ± 2.47/day). Similarly, episodes of nocturia were significantly fewer (OR 0.03; 95%CI 0.02 to 0.05) after 8 weeks of treatment (2.16 ± 1.49/night) versus placebo (3.14 ± 1.36/night). Symptoms of urgency (OR 0.02; 95%CI 0.01 to 0.03), and total incontinence (OR 0.03; 95% CI 0.01 to 0.06) were also lower (all p < 0.01) in the treatment group. Significant improvements in quality of life were reported after treatment in comparison to placebo. No significant side effects were observed resulting in withdrawal from treatment. CONCLUSIONS: The outcome of this study demonstrated both statistical significance and clinical relevance in reducing symptoms of OAB, urinary frequency and/or urgency and incontinence. The demonstrated viability of the herbal combination to serve as an effective treatment, with minimal side-effects, warrants further longer term research and consideration by clinicians. TRIAL REGISTRATION: NCT02396160 (registered on 17 March 2015 - before any statistical analyses commenced).
[Mh] Termos MeSH primário: Extratos Vegetais/uso terapêutico
Bexiga Urinária Hiperativa/tratamento farmacológico
Incontinência Urinária/tratamento farmacológico
Agentes Urológicos/uso terapêutico
[Mh] Termos MeSH secundário: Idoso
Capparaceae
Equisetum
Feminino
Seres Humanos
Lindera
Masculino
Registros Médicos
Meia-Idade
Fitoterapia
Extratos Vegetais/farmacologia
Micção/efeitos dos fármacos
Agentes Urológicos/farmacologia
[Pt] Tipo de publicação:CLINICAL TRIAL, PHASE II; JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Plant Extracts); 0 (Urological Agents)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180301
[Lr] Data última revisão:
180301
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180202
[Cl] Clinical Trial:ClinicalTrial
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-018-2101-4


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[PMID]:27951754
[Au] Autor:Eze JI; Ekelozie CF; Nweze NE
[Ad] Endereço:a Department of Veterinary Medicine , University of Nigeria , Nsukka , Nigeria.
[Ti] Título:Immunomodulatory activity of Buchholzia coriacea seed methanol extract on Trypanosoma brucei brucei infected mice.
[So] Source:Pharm Biol;55(1):636-640, 2017 Dec.
[Is] ISSN:1744-5116
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:CONTEXT: The seeds of Buchholzia coriacea Engler (Capparaceae) are used in Eastern Nigeria to treat feverish conditions, and to treat malaria and sleeping sickness that cause fever. OBJECTIVE: The current study assesses the immunomodulatory activity of Buchholzia coriacea seed extract on Trypanosoma brucei brucei infected mice. MATERIALS AND METHODS: Delayed hypersensitivity reaction, humoral antibody response and in-vivo leucocyte mobilization tests were assessed in three different experiments to determine the effect of the extract on immune response. Seventy-five (75) mice (25 mice per experiment) were used for the study and were each infected with 1.00 × 10 trypanosomes intra-peritoneally. Groups A, B and C were given 250, 500 and 1000 mg/kg of the extract, respectively, group D received 7.5 mg/kg body weight of levamisole and group E was the control. Sheep RBCs were used as antigen. RESULTS: The acute toxicity tests did not cause clinical signs or death within 24 h post treatment at all the doses tested. The extract inhibited delayed hypersensitivity reaction by 20.9 and 20.8% at 250 and 500 mg/kg, respectively, while at 1000 mg/kg, the paw size increased (-101.9%) when compared with the control. The extract elevated the antibody titre from 1.60 ± 0.40 for control to 8.00 ± 3.58 for 500 mg/kg group. The extract increased in total leucocytes counts. DISCUSSION AND CONCLUSION: The extract has a very wide safety margin and was able to improve immune response. The results of the present study showed that Buchholzia coriacea seed methanol extract possesses immunostimulatory activity on trypanosome-infected mice.
[Mh] Termos MeSH primário: Capparaceae/química
Fatores Imunológicos/farmacologia
Metanol/química
Extratos Vegetais/farmacologia
Sementes/química
Solventes/química
Tripanossomicidas/farmacologia
Trypanosoma brucei brucei/efeitos dos fármacos
Tripanossomíase Africana/tratamento farmacológico
[Mh] Termos MeSH secundário: Animais
Quimiotaxia de Leucócito/efeitos dos fármacos
Modelos Animais de Doenças
Relação Dose-Resposta a Droga
Edema/imunologia
Edema/parasitologia
Edema/prevenção & controle
Hipersensibilidade Tardia/imunologia
Hipersensibilidade Tardia/parasitologia
Hipersensibilidade Tardia/prevenção & controle
Imunidade Humoral/efeitos dos fármacos
Fatores Imunológicos/isolamento & purificação
Fatores Imunológicos/toxicidade
Dose Letal Mediana
Masculino
Camundongos
Fitoterapia
Extratos Vegetais/isolamento & purificação
Extratos Vegetais/toxicidade
Plantas Medicinais
Tripanossomicidas/isolamento & purificação
Tripanossomicidas/toxicidade
Trypanosoma brucei brucei/imunologia
Trypanosoma brucei brucei/patogenicidade
Tripanossomíase Africana/imunologia
Tripanossomíase Africana/parasitologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Immunologic Factors); 0 (Plant Extracts); 0 (Solvents); 0 (Trypanocidal Agents); Y4S76JWI15 (Methanol)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170313
[Lr] Data última revisão:
170313
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161214
[St] Status:MEDLINE


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[PMID]:27874198
[Au] Autor:Ali SG; Ansari MA; Khan HM; Jalal M; Mahdi AA; Cameotra SS
[Ad] Endereço:Department of Microbiology, Nanotechnology and Antimicrobial Drug Resistance Research Laboratory, Jawaharlal Nehru Medical College and Hospital, Aligarh Muslim University, Aligarh, Uttar Pradesh, India.
[Ti] Título:Crataeva nurvala nanoparticles inhibit virulence factors and biofilm formation in clinical isolates of Pseudomonas aeruginosa.
[So] Source:J Basic Microbiol;57(3):193-203, 2017 Mar.
[Is] ISSN:1521-4028
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Green synthesized nanoparticles have gained great attention due to their non-toxic and non-hazardous nature. In the present study, bark extract of the medicinal plant in Ayurveda Crataeva nurvala (Buch-Ham) (CN) was chosen for the biosynthesis of silver nanoparticles (AgNPs). These NPs were characterized by Ultra violet visible spectroscopy, Fourier Transform Infra Red, Atomic Force Microscopy, and Transmission Electron Microscopy (TEM). The average particle size of green synthesized CN-AgNPs was 15.2 ± 1.01 nm. Gas chromatography- mass spectrometry analysis of methanolic bark extract involved in the formation of CN-AgNPs revealed lupeol as a major active component. In this study, CN-AgNPs (15 µg ml ) efficiently suppressed the production of quorum sensing mediated virulence factors viz. pyocyanin, protease, hemolysin, and biofilm formation in Pseudomonas aeruginosa. The pyocyanin production was strongly inhibited (74.64%) followed by proteolysis (47.3%) and hemolysin production (47.7%). However, the biofilm forming ability was maximally reduced up to 79.70%. Moreover, the Confocal Laser Scanning Microscopic Analysis showed that CN-AgNPs inhibit colonization of P. aeruginosa on to the surface. Furthermore, TEM analysis revealed internalization of CN-AgNPs inside the bacterial cell. It is concluded that green synthesized AgNPs have great potential to inhibit virulence factors and biofilm forming ability of drug-resistant clinical isolates of P. aeruginosa.
[Mh] Termos MeSH primário: Biofilmes/efeitos dos fármacos
Capparaceae/química
Nanopartículas Metálicas/química
Extratos Vegetais/farmacologia
Pseudomonas aeruginosa/efeitos dos fármacos
Fatores de Virulência/antagonistas & inibidores
[Mh] Termos MeSH secundário: Antibacterianos/farmacologia
Biofilmes/crescimento & desenvolvimento
Farmacorresistência Bacteriana Múltipla
Proteínas Hemolisinas/antagonistas & inibidores
Proteínas Hemolisinas/biossíntese
Proteínas Hemolisinas/efeitos dos fármacos
Nanopartículas Metálicas/ultraestrutura
Microscopia Confocal
Microscopia Eletrônica de Transmissão
Triterpenos Pentacíclicos/farmacologia
Plantas Medicinais/química
Proteólise/efeitos dos fármacos
Infecções por Pseudomonas/microbiologia
Pseudomonas aeruginosa/fisiologia
Pseudomonas aeruginosa/ultraestrutura
Piocianina/biossíntese
Percepção de Quorum/efeitos dos fármacos
Prata
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Hemolysin Proteins); 0 (Pentacyclic Triterpenes); 0 (Plant Extracts); 0 (Virulence Factors); 3M4G523W1G (Silver); 9OQM399341 (Pyocyanine); O268W13H3O (lupeol)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170328
[Lr] Data última revisão:
170328
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161123
[St] Status:MEDLINE
[do] DOI:10.1002/jobm.201600175


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[PMID]:27574770
[Au] Autor:Onasanwo SA; Faborode SO; Ilenre KO
[Ad] Endereço:Neurosciences and Oral Physiology Unit, Department of Physiology, University of Ibadan, Ibadan. samphil2002@yahoo.com.
[Ti] Título:Antidepressant-like Potentials of Buchholzia Coriacea Seed Extract: Involvement of Monoaminergic and Cholinergic Systems, and Neuronal Density in the Hippocampus of Adult Mice.
[So] Source:Niger J Physiol Sci;31(1):93-9, 2016 Aug 30.
[Is] ISSN:0794-859X
[Cp] País de publicação:Nigeria
[La] Idioma:eng
[Ab] Resumo:Buchholzia coriacea, taken by elderly, has phytochemicals that have neuro-active metabolites, and the folkloredocumented its use in neuro-behavioral despairs. Previous study in our laboratory shows that methanol extracts of Buchholziacoriacea (MEBC) seeds possess antidepressant-like potentials in laboratory rodents. This present study was conducted toinvestigate the probable mechanism(s) of action by which MEBC potentiates its effects using laboratory rodents.Involvements of serotonergic, cholinergic and adrenergic systems were studied using Forced Swimming Test (FST) and TailSuspension Test (TST) models of behavioral despair. Antagonists which including: Prazosin, an alpha-1-adrenergic receptorblocker (62.5 µg/kg, i.p.), metergoline, a 5HT2 receptor blocker (4 mg/kg, i.p.) and atropine, a -muscarinic cholinergicreceptor blocker (1mg/kg i.p.) were administered before effective dose of MEBC (50mg/kg). Also, the hippocampi of theanimals were studied for changes in neuronal density using Nissl Staining. Our findings showed that mobility was reversedin animals pre-treated with atropine, prazosin, and metergoline significantly (P˂0.05), showing a possible involvement ofthe corresponding systems. However, there was a significant reduction in immobility time (P<0.001) during FST afterchronic administration of the MEBC. The hippocampus showed no significant changes (P<0.05) in neuronal density. Inconclusion, MEBC probably potentiates its antidepressant-like potentials via the cholinergic, adrenergic and partly byserotonergic systems.
[Mh] Termos MeSH primário: Antidepressivos/farmacologia
Monoaminas Biogênicas/antagonistas & inibidores
Capparaceae
Hipocampo/citologia
Antagonistas Muscarínicos/farmacologia
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Antagonistas Adrenérgicos/farmacologia
Animais
Antidepressivos/isolamento & purificação
Feminino
Hipocampo/efeitos dos fármacos
Camundongos
Neurônios/efeitos dos fármacos
Extratos Vegetais/isolamento & purificação
Sementes
Antagonistas da Serotonina/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Adrenergic Antagonists); 0 (Antidepressive Agents); 0 (Biogenic Monoamines); 0 (Muscarinic Antagonists); 0 (Plant Extracts); 0 (Serotonin Antagonists)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170313
[Lr] Data última revisão:
170313
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160831
[St] Status:MEDLINE


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[PMID]:27314028
[Au] Autor:Wang Q; Zhang ML; Yin LK
[Ad] Endereço:Key Laboratory of Biogeography and Bioresource in Arid Land, Xinjiang Institute of Ecology and Geography, Chinese Academy of Sciences, Urumqi, Xinjiang 830011, China; University of Chinese Academy of Sciences, Beijing 100049, China.
[Ti] Título:Phylogeographic Structure of a Tethyan Relict Capparis spinosa (Capparaceae) Traces Pleistocene Geologic and Climatic Changes in the Western Himalayas, Tianshan Mountains, and Adjacent Desert Regions.
[So] Source:Biomed Res Int;2016:5792708, 2016.
[Is] ISSN:2314-6141
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Complex geological movements more or less affected or changed floristic structures, while the alternation of glacials and interglacials is presumed to have further shaped the present discontinuous genetic pattern of temperate plants. Here we consider Capparis spinosa, a xeromorphic Tethyan relict, to discuss its divergence pattern and explore how it responded in a stepwise fashion to Pleistocene geologic and climatic changes. 267 individuals from 31 populations were sampled and 24 haplotypes were identified, based on three cpDNA fragments (trnL-trnF, rps12-rpl20, and ndhF). SAMOVA clustered the 31 populations into 5 major clades. AMOVA suggests that gene flow between them might be restricted by vicariance. Molecular clock dating indicates that intraspecific divergence began in early Pleistocene, consistent with a time of intense uplift of the Himalaya and Tianshan Mountains, and intensified in mid-Pleistocene. Species distribution modeling suggests range reduction in the high mountains during the Last Glacial Maximum (LGM) as a result of cold climates when glacier advanced, while gorges at midelevations in Tianshan appear to have served as refugia. Populations of low-altitude desert regions, on the other hand, probably experienced only marginal impacts from glaciation, according to the high levels of genetic diversity.
[Mh] Termos MeSH primário: Adaptação Fisiológica/genética
Capparaceae/genética
DNA de Plantas/genética
Clima Desértico
Ecossistema
[Mh] Termos MeSH secundário: Altitude
China
Evolução Molecular
Variação Genética
Filogeografia/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Plant)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160618
[St] Status:MEDLINE
[do] DOI:10.1155/2016/5792708


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[PMID]:27267829
[Au] Autor:Zingue S; Cisilotto J; Tueche AB; Bishayee A; Mefegue FA; Sandjo LP; Magne Nde CB; Winter E; Michel T; Ndinteh DT; Awounfack CF; Silihe KK; Melachio Tanekou TT; Creczynski-Pasa TB; Njamen D
[Ad] Endereço:Department of Life and Earth Sciences, Higher Teachers' Training College, University of Maroua, Maroua, Cameroon; Department of Animal Biology and Physiology, Faculty of Science, University of Yaoundé 1, Yaounde, Cameroon; Department of Pharmaceutical Sciences, Health Sciences Centre, Federal Univer
[Ti] Título:Crateva adansonii DC, an African ethnomedicinal plant, exerts cytotoxicity in vitro and prevents experimental mammary tumorigenesis in vivo.
[So] Source:J Ethnopharmacol;190:183-99, 2016 Aug 22.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:ETHNOPHARMACOLOGICAL RELEVANCE: Crateva adansonii DC is a plant traditionally used in Cameroon to treat constipation, asthma, snakebites, postmenopausal complaints and cancers. AIM: The anticancer potential of the dichloromethane/methanol extract of C. adansonii stem barks was investigated using human breast cancer cell and 7,12 dimethylbenz(a)anththracene (DMBA)-induced mammary tumorigenesis model in rats. MATERIAL AND METHODS: The cytotoxicity of C. adansonii extract was assessed in vitro towards breast carcinoma (MCF-7 and MDA-MB-231) and non-tumoral cell lines (NIH/3T3 and HUVEC) by Alamar Blue assay. Furthermore, in vivo studies were performed on female Wistar rats treated either with C. adansonii extract at a dose of 75 or 300mg/kg body weight or with tamoxifen (3.3mg/kg body weight), starting 1 week prior DMBA treatment and lasted 12 weeks. The investigation focused on tumour burden, tumour DNA fingerprint, morphological, histological, hematological, and biochemical parameters. RESULTS: CC50 values for the in vitro assays were 289µg/mL against MCF-7 cells and >500µg/mL in others cells, leading to a selectivity index ≥1.73. C. adansonii extract significantly (p<0.001) revealed in vivo the reduction of the cumulative tumour yield (87.23%), total tumour burden (88.64%), average tumour weight (71.11%) and tumour volume (78.07%) at the dose of 75mg/kg as compared to DMBA control group. A weak effect was also observed at 300mg/kg. This extract showed a moderate hyperplasia at the dose of 75mg/kg while at 300mg/kg no significant change was noted as compared to DMBA group. It protected rats from the DNA alteration induced by DMBA and increased antioxydant enzymes activities in mammary gland tissue homogenates. In addition, Ultra-High Performance Liquid Chromatography/ESI-QTOF-Mass Spectrometry analysis of C. adansonii extract detected structure-related of many well-known anticancer agents such as flavane gallate, flavonol, phenylpropanoïds, sesquiterpene derivatives, gallotannins and lignans. The LD50 of C. adansonii was estimated to be greater than 5000mg/kg. CONCLUSIONS: These aforementioned results suggest that the C. adansonii extract may possess antitumor constituents, which could combat breast cancer and prevent chemically-induced breast cancer in rats.
[Mh] Termos MeSH primário: Anticarcinógenos/farmacologia
Antineoplásicos Fitogênicos/farmacologia
Neoplasias da Mama/tratamento farmacológico
Capparaceae/química
Neoplasias Mamárias Experimentais/prevenção & controle
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: 9,10-Dimetil-1,2-benzantraceno
África
Animais
Anticarcinógenos/química
Anticarcinógenos/isolamento & purificação
Anticarcinógenos/toxicidade
Antineoplásicos Fitogênicos/química
Antineoplásicos Fitogênicos/isolamento & purificação
Antineoplásicos Fitogênicos/toxicidade
Neoplasias da Mama/genética
Neoplasias da Mama/metabolismo
Neoplasias da Mama/patologia
Cromatografia Líquida
Dano ao DNA/efeitos dos fármacos
Relação Dose-Resposta a Droga
Etnobotânica
Feminino
Células Endoteliais da Veia Umbilical Humana/efeitos dos fármacos
Células Endoteliais da Veia Umbilical Humana/patologia
Seres Humanos
Concentração Inibidora 50
Dose Letal Mediana
Células MCF-7
Neoplasias Mamárias Experimentais/induzido quimicamente
Neoplasias Mamárias Experimentais/patologia
Medicina Tradicional Africana
Camundongos
Estrutura Molecular
Células NIH 3T3
Estresse Oxidativo/efeitos dos fármacos
Fitoterapia
Extratos Vegetais/química
Extratos Vegetais/isolamento & purificação
Extratos Vegetais/toxicidade
Plantas Medicinais
Ratos Wistar
Espectrometria de Massas por Ionização por Electrospray
Tamoxifeno/farmacologia
Fatores de Tempo
Carga Tumoral/efeitos dos fármacos
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anticarcinogenic Agents); 0 (Antineoplastic Agents, Phytogenic); 0 (Plant Extracts); 094ZI81Y45 (Tamoxifen); 57-97-6 (9,10-Dimethyl-1,2-benzanthracene)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170418
[Lr] Data última revisão:
170418
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160609
[St] Status:MEDLINE


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[PMID]:26568149
[Au] Autor:Nunes NN; Ferreira RS; Silva-Lucca RA; de Sá LF; de Oliveira AE; Correia MT; Paiva PM; Wlodawer A; Oliva ML
[Ad] Endereço:Departamento de Bioquímica, Universidade Federal de São Paulo-UNIFESP-EPM , 04044-020 São Paulo, SP, Brazil.
[Ti] Título:Potential of the Lectin/Inhibitor Isolated from Crataeva tapia Bark (CrataBL) for Controlling Callosobruchus maculatus Larva Development.
[So] Source:J Agric Food Chem;63(48):10431-6, 2015 Dec 09.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Callosobruchus maculatus is an important predator of cowpeas. Due to infestation during storage, this insect affects the quality of seed and crop yield. This study aimed to investigate the effects of CrataBL, a multifunction protein isolated from Crataeva tapia bark, on C. maculatus larva development. The protein, which is stable even in extreme pH conditions, showed toxic activity, reducing the larval mass 45 and 70% at concentrations of 0.25 and 1.0% (w/w), respectively. Acting as an inhibitor, CrataBL decreased by 39% the activity of cysteine proteinases from larval gut. Conversely, the activity of serine proteinases was increased about 8-fold. The toxic properties of CrataBL may also be attributed to its capacity of binding to glycoproteins or glycosaminoglycans. Such binding interferes with larval metabolism, because CrataBL-FITC was found in the fat body, Malpighian tubules, and feces of larvae. These results demonstrate the potential of this protein for controlling larva development.
[Mh] Termos MeSH primário: Capparaceae/química
Coleópteros/efeitos dos fármacos
Larva/crescimento & desenvolvimento
Lectinas/farmacologia
Casca de Planta/química
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Animais
Coleópteros/enzimologia
Coleópteros/crescimento & desenvolvimento
Cisteína Proteases/metabolismo
Inibidores de Cisteína Proteinase/farmacologia
Proteínas de Insetos/metabolismo
Larva/efeitos dos fármacos
Larva/enzimologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Cysteine Proteinase Inhibitors); 0 (Insect Proteins); 0 (Lectins); 0 (Plant Extracts); EC 3.4.- (Cysteine Proteases)
[Em] Mês de entrada:1608
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151117
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.5b03634


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[PMID]:25781717
[Au] Autor:Ezike AC; Onyeto CA; Nwabunike IA; Mbaoji FN; Attah BE; Amanambu SO; Okoli CO
[Ti] Título:Anti-inflammatory activity of Buchholzia coriacea Engl. (Capparaceae) leaf extract: evaluation of components of the inflammatory response involved.
[So] Source:J Complement Integr Med;12(2):153-8, 2015 Jun.
[Is] ISSN:1553-3840
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Earlier studies in our laboratory demonstrated the anti-inflammatory activity of Buchholzia coriacea Engl. (Capparaceae) leaf extract, a herbal remedy used to treat disorders of inflammation. This study was undertaken to evaluate its anti-inflammatory mechanism(s). METHODS: The effects of methanol leaf extract of B. coriacea (200 and 400 mg/kg) on vascular permeability and leukocyte migration were studied in rodents, while activity on complement system and membrane stabilization were evaluated in vitro. RESULTS: The extract (200 and 400 mg/kg) inhibited acetic acid-induced increase in vascular permeability in a non-dose-related manner and significantly (p < 0.05) reduced the total and differential leukocyte counts, respectively, in a dose-related manner. It also significantly (p < 0.05) inhibited complement-induced hemolysis of sheep red blood cells (40-72%) and moderately inhibited heat- (6%) and hypotonic solution-(24%) induced hemolysis in vitro in a non-dose-related manner. CONCLUSIONS: Results demonstrated that the anti-inflammatory activity of B. coriacea leaf extract is mediated through inhibition of increase in vascular permeability, leukocyte migration and complement system, and enhanced membrane stabilization.
[Mh] Termos MeSH primário: Anti-Inflamatórios/uso terapêutico
Capparaceae
Inflamação/tratamento farmacológico
Fitoterapia
Extratos Vegetais/uso terapêutico
[Mh] Termos MeSH secundário: Ácido Acético
Animais
Anti-Inflamatórios/farmacologia
Permeabilidade Capilar
Membrana Celular
Proteínas do Sistema Complemento/metabolismo
Eritrócitos
Hemólise
Temperatura Alta
Inflamação/sangue
Contagem de Leucócitos
Leucócitos/metabolismo
Camundongos
Extratos Vegetais/farmacologia
Folhas de Planta
Ratos Sprague-Dawley
Ovinos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Plant Extracts); 9007-36-7 (Complement System Proteins); Q40Q9N063P (Acetic Acid)
[Em] Mês de entrada:1602
[Cu] Atualização por classe:170328
[Lr] Data última revisão:
170328
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150318
[St] Status:MEDLINE


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[PMID]:25571844
[Au] Autor:Cho YC; Ju A; Kim BR; Cho S
[Ad] Endereço:College of Pharmacy, Chung-Ang University, Seoul 156-756, Republic of Korea.
[Ti] Título:Anti-inflammatory effects of Crataeva nurvala Buch. Ham. are mediated via inactivation of ERK but not NF-κB.
[So] Source:J Ethnopharmacol;162:140-7, 2015 Mar 13.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:ETHNOPHARMACOLOGICAL RELEVANCE: Crataeva nurvala Buch. Ham. is an important medicinal plant in India, and its extracts and components were used to treat various inflammatory diseases, such as urinary tract infection, rheumatoid arthritis, and colitis. However, no systemic studies about anti-inflammatory effects of Crataeva nurvala Buch. Ham. and its underlying mechanisms of action have been reported. This study aimed to explore the anti-inflammatory effects of ethanol extracts of Crataeva nurvala Buch. Ham. (ECN). MATERIALS AND METHODS: The non-cytotoxic and maximal effective concentration of ECN was determined by measuring the formation of formazan from water-soluble tetrazolium salt in living cells. The inhibitory effect of ECN on nitric oxide (NO) synthesis was measured using Griess reagent, and Enzyme-linked immunosorbent assay (ELISA) was used to measure secreted tumor necrosis factor (TNF)-α and interleukin (IL)-6 protein levels. Furthermore, reverse transcription polymerase chain reaction (RT-PCR) and Western blotting analysis were used to assess the mRNA and protein expression of each inflammatory mediator or relating signaling protein, respectively. RESULTS: A non-cytotoxic concentration of ECN (≤200 µg/ml) significantly reduced the production of NO and IL-6, but not TNF-α, in lipopolysaccharides (LPS)-stimulated RAW 264.7 macrophages. Decreased production of NO by ECN was correlated with reduced expression of iNOS at the mRNA and protein levels. However, cyclooxygenase (COX)-2 expressions at mRNA and protein level were not regulated by ECN. The mRNA expression of IL-6 and IL-1ß, but not TNF-α, was also inhibited by ECN treatment in LPS-stimulated RAW 264.7 macrophages. Reduced production of inflammatory mediators by ECN was followed by decreased activity of mitogen-activated protein kinases (MAPKs), especially extracellular signal-regulated kinase (ERK), but not nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB). CONCLUSIONS: These results indicate that ECN inhibits LPS-induced inflammatory responses via negative regulation of ERK in murine macrophages, suggesting that ECN is a candidate for alleviating severe inflammation.
[Mh] Termos MeSH primário: Anti-Inflamatórios/farmacologia
Capparaceae
MAP Quinases Reguladas por Sinal Extracelular/metabolismo
NF-kappa B/metabolismo
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Animais
Linhagem Celular
Citocinas/metabolismo
Proteínas Quinases JNK Ativadas por Mitógeno/metabolismo
Lipopolissacarídeos
Camundongos
Nitritos/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Cytokines); 0 (Lipopolysaccharides); 0 (NF-kappa B); 0 (Nitrites); 0 (Plant Extracts); EC 2.7.11.24 (Extracellular Signal-Regulated MAP Kinases); EC 2.7.11.24 (JNK Mitogen-Activated Protein Kinases)
[Em] Mês de entrada:1603
[Cu] Atualização por classe:150217
[Lr] Data última revisão:
150217
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150110
[St] Status:MEDLINE


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[PMID]:25248349
[Au] Autor:Moniruzzaman M; Imam MZ
[Ti] Título:Evaluation of antinociceptive effect of methanolic extract of leaves of Crataeva nurvala Buch.-Ham.
[So] Source:BMC Complement Altern Med;14:354, 2014 Sep 24.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Crataeva nurvala Buch.-Ham. (Family: Capparidaceae) is widely used as anti-inflammatory, contraceptive, laxative, lithotropic, febrifuge and as tonic in traditional medicine. This study evaluated the antinociceptive effect of the methanolic extract of the leaves of Crataeva nurvala (MECN). METHODS: The antinociceptive activity was investigated using heat-induced (hot-plate and tail-immersion test) and chemical-induced (acetic acid, formalin and glutamic acid) nociception models in mice at different doses (50, 100, and 200 mg/kg, p.o.) of MECN. Morphine sulphate (5 mg/kg, i.p.) and diclofenac sodium (10 mg/kg, i. p.) were used as reference analgesic drugs. RESULTS: MECN produced significant dose-dependent antinociception when assessed using hot plate test, tail immersion test and acetic acid-induced abdominal writhing test (65.55%). Likewise, MECN at similar doses produced significant dose-dependent inhibition in both neurogenic (50.82%) and inflammatory pain (73.53%) induced by intraplantar injection of formalin (2.5% formalin, 20 µl/paw). Besides, MECN also significantly inhibited the glutamate-induced (10 µM/paw) pain in mice (74.68%). It was demonstrated that pretreatment with naloxone (2 mg/kg, i.p.) significantly reversed antinociception produced by MECN in hot plate and tail immersion test suggesting the involvement of opioid receptor. In addition, administration of glibenclamide (10 mg/kg, i.p.), an ATP-sensitive K+ channel antagonist could not reverse antinociceptive activity induced by MECN. CONCLUSION: The results suggest that MECN possesses antinociceptive activity involving inhibition of opioid system as well as the glutamatergic system supporting its traditional uses.
[Mh] Termos MeSH primário: Analgésicos/farmacologia
Capparaceae/química
Dor/tratamento farmacológico
Extratos Vegetais/farmacologia
Folhas de Planta/química
[Mh] Termos MeSH secundário: Analgésicos/química
Analgésicos/toxicidade
Animais
Comportamento Animal/efeitos dos fármacos
Metanol/química
Camundongos
Naloxona/farmacologia
Dor/fisiopatologia
Manejo da Dor
Extratos Vegetais/química
Extratos Vegetais/toxicidade
Plantas Medicinais/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Analgesics); 0 (Plant Extracts); 36B82AMQ7N (Naloxone); Y4S76JWI15 (Methanol)
[Em] Mês de entrada:1412
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140925
[St] Status:MEDLINE
[do] DOI:10.1186/1472-6882-14-354



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