Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.177.500 [Categoria DeCS]
Referências encontradas : 132 [refinar]
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[PMID]:28143472
[Au] Autor:El Azhary K; Tahiri Jouti N; El Khachibi M; Moutia M; Tabyaoui I; El Hou A; Achtak H; Nadifi S; Habti N; Badou A
[Ad] Endereço:Environnement and Health team, Polydisciplinary Faculty of Safi, Cadi Ayyad University, Safi, Morocco.
[Ti] Título:Anti-inflammatory potential of Capparis spinosa L. in vivo in mice through inhibition of cell infiltration and cytokine gene expression.
[So] Source:BMC Complement Altern Med;17(1):81, 2017 Jan 31.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Several chronic inflammatory diseases are characterized by inappropriate CD4+ T cell response. In the present study, we assessed the ability of Capparis spinosa L. (CS) preparation to orientate, in vivo, the immune response mediated by CD4+ T cells towards an anti-inflammatory response. METHODS: The in vivo study was carried out by using the contact hypersensitivity (CHS) model in Swiss mice. Then we performed a histological analysis followed by molecular study by using real time RT-PCR. We also realized a phytochemical screening and a liquid-liquid separation of CS preparation. RESULTS: Our study allowed us to detect a significantly reduced edema in mice treated with CS preparations relative to control. CS effect was dose dependent, statistically similar to that observed with indomethacin, independent of the plant genotype and of the period of treatment. Furthermore, our histology studies revealed that CS induced a significant decrease in immune cell infiltration, in vasodilatation and in dermis thickness in the inflammatory site. Interestingly, we showed that CS operated by inhibiting cytokine gene expression including IFNγ, IL-17 and IL-4. Besides, phytochemical screening of CS extract showed the presence of several chemical families such as saponins, flavonoids and alkaloids. One (hexane fraction) out of the three distinct prepared fractions, exhibited an anti-inflammatory effect similar to that of the raw preparation, and would likely contain the bioactive(s) molecule(s). CONCLUSIONS: Altogether, our data indicate that CS regulates inflammation induced in vivo in mice and thus could be a source of anti-inflammatory molecules, which could be used in some T lymphocyte-dependent inflammatory diseases.
[Mh] Termos MeSH primário: Anti-Inflamatórios não Esteroides/farmacologia
Capparis/química
Citocinas/genética
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Acetatos
Animais
Anti-Inflamatórios não Esteroides/isolamento & purificação
Capparis/genética
Dermatite de Contato/tratamento farmacológico
Dermatite de Contato/etiologia
Dinitrofluorbenzeno
Feminino
Expressão Gênica/efeitos dos fármacos
Genótipo
Hexanos
Inflamação/induzido quimicamente
Inflamação/tratamento farmacológico
Inflamação/patologia
Metanol
Camundongos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acetates); 0 (Anti-Inflammatory Agents, Non-Steroidal); 0 (Cytokines); 0 (Hexanes); 0 (Plant Extracts); 76845O8NMZ (ethyl acetate); D241E059U6 (Dinitrofluorobenzene); Y4S76JWI15 (Methanol)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170202
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-1569-7


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[PMID]:28067853
[Au] Autor:Hamuti A; Li J; Zhou F; Aipire A; Ma J; Yang J; Li J
[Ad] Endereço:Xinjiang Key Laboratory of Biological Resources and Genetic Engineering, College of Life Science and Technology, Xinjiang University, 666 Shengli Road, Urumqi 830046, China. 13070411128@163.com.
[Ti] Título:Capparis spinosa Fruit Ethanol Extracts Exert Different Effects on the Maturation of Dendritic Cells.
[So] Source:Molecules;22(1), 2017 Jan 07.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:L. ( ) has been used as food and traditional medicine and shows anti-inflammatory and anti-oxidant activities. Here, we prepared the fruit ethanol extracts (CSEs) using different procedures and investigated the effects of CSE on the maturation of mouse bone marrow-derived dendritic cells (DCs) in the absence or presence of lipopolysaccharide (LPS). DC maturation and cytokine production were detected by flow cytometry and ELISA, respectively. We obtained three different CSEs and dissolved in water or DMSO, named CSE2W, CSEMW, CSE3W, CSE2D, CSEMD, and CSE3D, respectively. These CSEs showed different effects on DC maturation. CSEMW and CSEMD significantly increased the expressions of CD40, CD80, and CD86, in a dose-dependent manner. CSE2W and CSE2D also showed a modest effect on DC maturation, which enhanced the expression of CD40. CSE3W and CSE3D did not change DC maturation but suppressed LPS-induced DC maturation characterized by the decreased levels of CD40 and CD80. CSE3W and CSE3D also significantly inhibited the secretions of IL-12p40, IL-6, IL-1ß, and TNF-α induced by LPS. CSE3W further increased the level of IL-10 induced by LPS. Moreover, CSE3D suppressed LPS-induced DC maturation in vivo, which decreased the expressions of CD40 and CD80. These results suggested that CSE3W and CSE3D might be used to treat inflammatory diseases.
[Mh] Termos MeSH primário: Capparis/química
Diferenciação Celular/efeitos dos fármacos
Células Dendríticas/citologia
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Animais
Antígeno B7-1/biossíntese
Antígeno B7-2/biossíntese
Células da Medula Óssea/citologia
Antígenos CD40/biossíntese
Células Dendríticas/efeitos dos fármacos
Ensaio de Imunoadsorção Enzimática
Etanol/metabolismo
Citometria de Fluxo
Frutas/metabolismo
Interleucina-10/secreção
Subunidade p40 da Interleucina-12/secreção
Interleucina-1beta/secreção
Interleucina-6/secreção
Lipopolissacarídeos
Medicina Tradicional do Leste Asiático
Camundongos
Camundongos Endogâmicos BALB C
Fator de Necrose Tumoral alfa/secreção
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (B7-1 Antigen); 0 (B7-2 Antigen); 0 (CD40 Antigens); 0 (IL10 protein, mouse); 0 (IL1B protein, mouse); 0 (Interleukin-12 Subunit p40); 0 (Interleukin-1beta); 0 (Interleukin-6); 0 (Lipopolysaccharides); 0 (Plant Extracts); 0 (Tumor Necrosis Factor-alpha); 0 (interleukin-6, mouse); 130068-27-8 (Interleukin-10); 3K9958V90M (Ethanol)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170110
[St] Status:MEDLINE


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[PMID]:28056421
[Au] Autor:Tlili N; Feriani A; Saadoui E; Nasri N; Khaldi A
[Ad] Endereço:Laboratoire de biochimie, Faculté des Sciences de Tunis, Université Tunis El-Manar, 2092 Tunis, Tunisie; Institut National de Recherches en Génie Rural, Eaux et Forêts, Université de Carthage, BP 10, Ariana 2080, Tunisie. Electronic address: Nizar.Tlili@fst.rnu.tn.
[Ti] Título:Capparis spinosa leaves extract: Source of bioantioxidants with nephroprotective and hepatoprotective effects.
[So] Source:Biomed Pharmacother;87:171-179, 2017 Mar.
[Is] ISSN:1950-6007
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:Capparis spinosa, Capparidaceae, is largely distributed all over the Mediterranean Basin and is traditionally used to treat many illnesses, such as liver and kidney diseases. The aim of the current study was to explore the antioxidant, nephroprotective and hepatoprotective effects of methanolic extract of Capparis spinosa leaves (MECS) associated with its phytochemical content. The levels of total phenolics, flavonoids and condensed tannins were 23.37mgGAE/g, 9.05mgQE/g and 9.35mgTAE/g, respectively. HPLC analysis revealed nine compounds, namely rutin, resveratrol, coumarin, epicatechin, luteolin, catechin, kaempferol, vanillic acid and gallic acid. The MECS showed interesting antioxidant capacity. The MECS-treatment significantly reduced the increased plasma levels of creatinine, urea and uric acid, reduced the elevated MDA levels, significantly reduced the antioxidant enzyme activities and restored the kidney damage, provoked by cisplatin-treatment. Furthermore, MECS-treatment significantly prevented the increase in serum ALT, AST and LDH levels in acute liver damage induced by CCl , decreased the amount of hepatic malondialdehyde (MDA) formation and elevated the activities of SOD, CAT and GPx, and restored liver injury. This study supports the traditionally use of C. spinosa to cure kidney and liver diseases. The obtained results highlighted the possible use of C. spinosa as a source of phytochemical with important biological advantages.
[Mh] Termos MeSH primário: Antioxidantes/farmacologia
Capparis
Rim/metabolismo
Fígado/metabolismo
Extratos Vegetais/farmacologia
Folhas de Planta
[Mh] Termos MeSH secundário: Animais
Antioxidantes/isolamento & purificação
Rim/efeitos dos fármacos
Rim/patologia
Peroxidação de Lipídeos/efeitos dos fármacos
Peroxidação de Lipídeos/fisiologia
Fígado/efeitos dos fármacos
Fígado/patologia
Masculino
Extratos Vegetais/isolamento & purificação
Substâncias Protetoras/isolamento & purificação
Substâncias Protetoras/farmacologia
Ratos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Plant Extracts); 0 (Protective Agents)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170710
[Lr] Data última revisão:
170710
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170106
[St] Status:MEDLINE


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[PMID]:27902318
[Au] Autor:Wang HF; Li QL; Xiao M; Zhang YG; Zhou XK; Narsing Rao MP; Duan YQ; Li WJ
[Ad] Endereço:1​College of Life Science, Liaoning Normal University, Dalian 116029, PR China 2​Key Laboratory of Biogeography and Bioresource in Arid Land, Xinjiang Institute of Ecology and Geography, Chinese Academy of Sciences, Ürumqi 830011, PR China.
[Ti] Título:Streptomyces capparidis sp. nov., a novel endophytic actinobacterium isolated from fruits of Capparis spinosa L.
[So] Source:Int J Syst Evol Microbiol;67(1):133-137, 2017 Jan.
[Is] ISSN:1466-5034
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A novel endophytic actinobacterial strain, designated EGI 6500195T, was isolated from fruits of Capparis spinosa. Growth occurred at 10-45 °C (optimum 30 °C), at pH 6-8 (optimum pH 7) and in the presence of 0-1 % (w/v) NaCl. Strain EGI 6500195T shared highest 16S rRNA gene sequence similarity (97.74 %) with Streptomyces vitaminophilus DSM 41686T and less than 97 % sequence similarity with other members of the genus Streptomyces. The diagnostic amino acid in the peptidoglycan was ll-diaminopimelic acid. Whole-cell hydrolysates contained glucose, ribose, fructose and mannose. The predominant menaquinones were MK-9(H6) and MK-9(H8). The polar lipid profile of strain EGI 6500195T included diphosphatidylglycerol, phosphatidylglycerol, phosphatidylmethylethanolamine, phosphatidylinositol, phosphatidylcholine, three unknown phospholipids, an unknown aminophospholipid and an unknown aminolipid. The cellular fatty acids were anteiso-C15 : 0, anteiso-C17 : 0, iso-C15 : 0, iso-C16 : 0, anteiso-C17 : 1ω9c, summed feature 4 (iso-C17 : 1 I and/or anteiso-C17 : 1 B) and iso-C17 : 1ω9c. The DNA G+C content of strain EGI 6500195T was 74.1 mol%. The level of DNA-DNA relatedness between strain EGI 6500195T and Streptomyces. vitaminophilus DSM 41686T was 14.1±3.5 %. On the basis of the phenotypic, phylogenetic, chemotaxonomic and DNA-DNA hybridization data, strain EGI 6500195T represents a novel species of the genus Streptomyces, for which the name Streptomyces capparidis sp. nov. is proposed. The type strain is EGI 6500195T (=DSM 42145T=JCM 30089T).
[Mh] Termos MeSH primário: Capparis/microbiologia
Frutas/microbiologia
Filogenia
Streptomyces/classificação
[Mh] Termos MeSH secundário: Técnicas de Tipagem Bacteriana
Composição de Bases
China
DNA Bacteriano/genética
Ácido Diaminopimélico/química
Ácidos Graxos/química
Hibridização de Ácido Nucleico
Peptidoglicano/química
Fosfolipídeos/química
RNA Ribossômico 16S/genética
Análise de Sequência de DNA
Streptomyces/genética
Streptomyces/isolamento & purificação
Vitamina K 2/análogos & derivados
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Bacterial); 0 (Fatty Acids); 0 (Peptidoglycan); 0 (Phospholipids); 0 (RNA, Ribosomal, 16S); 11032-49-8 (Vitamin K 2); 523-39-7 (menaquinone 9); 583-93-7 (Diaminopimelic Acid)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170818
[Lr] Data última revisão:
170818
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161201
[St] Status:MEDLINE
[do] DOI:10.1099/ijsem.0.001586


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[PMID]:27902223
[Au] Autor:Wang HF; Li QL; Zhang YG; Xiao M; Zhou XK; Guo JW; Duan YQ; Li WJ
[Ad] Endereço:1​College of Life Science, Liaoning Normal University, Dalian 116029, PR China 2​Key Laboratory of Biogeography and Bioresource in Arid Land, Xinjiang Institute of Ecology and Geography, Chinese Academy of Sciences, Ürumqi 830011, PR China.
[Ti] Título:Bacillus capparidis sp. nov., an endophytic bacterium isolated from roots of Capparis spinosa L.
[So] Source:Int J Syst Evol Microbiol;67(2):282-287, 2017 Feb.
[Is] ISSN:1466-5034
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A novel endophytic bacterium, designated strain EGI 6500252T, was isolated from the surface-sterilized roots of a medicinal plant (Capparis spinosa L.) collected from Urumqi city, Xinjiang, north-west China. Cells were Gram-stain-positive, non-motile, aerobic, catalase- and oxidase-positive, rod-shaped and did not display spore formation. Strain EGI 6500252T grew at 10-40 °C (optimum 25-30 °C), at pH 6.0-8.0 (optimum pH 7.0) and in the presence of 0-10 % (w/v) NaCl (optimum 0-3 %). The major cellular fatty acids (>10 %) were identified as iso-C15 : 0, anteiso-C15 : 0, anteiso-C17 : 0 and summed feature 4. The predominant polar lipids were diphosphatidylglycerol, phosphatidylethanolamine, phosphatidylglycerol, four unknown phospholipids, one unknown glycolipid and one unknown lipid. The dominant isoprenoid quinone was menaquinone 7 (MK-7). The DNA G+C content was 39.9 mol%. Phylogenetic analysis based on 16S rRNA gene sequences indicated that strain EGI 6500252T belonged to the genus Bacillus, and exhibited a highest 16S rRNA gene sequence similarity (96.2 %) that was lower than the suggested threshold (97.0 %) for separating bacterial species. On the basis of the phylogenetic analysis, chemotaxonomic data and physiological characteristics, strain EGI 6500252T represents a novel species of the genus Bacillus, for which the name Bacillus capparidis sp. nov. is proposed. The type strain is EGI 6500252T (=CGMCC 1.12820T=KCTC 33514T).
[Mh] Termos MeSH primário: Bacillus/classificação
Capparis/microbiologia
Filogenia
Raízes de Plantas/microbiologia
[Mh] Termos MeSH secundário: Bacillus/genética
Bacillus/isolamento & purificação
Técnicas de Tipagem Bacteriana
Composição de Bases
China
DNA Bacteriano/genética
Ácidos Graxos/química
Glicolipídeos/química
Hibridização de Ácido Nucleico
Fosfolipídeos/química
RNA Ribossômico 16S/genética
Análise de Sequência de DNA
Vitamina K 2/análogos & derivados
Vitamina K 2/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Bacterial); 0 (Fatty Acids); 0 (Glycolipids); 0 (Phospholipids); 0 (RNA, Ribosomal, 16S); 11032-49-8 (Vitamin K 2); 8427BML8NY (vitamin MK 7)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170421
[Lr] Data última revisão:
170421
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161201
[St] Status:MEDLINE
[do] DOI:10.1099/ijsem.0.001616


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[PMID]:27878299
[Au] Autor:Yu L; Yang J; Wang X; Jiang B; Sun Y; Ji Y
[Ad] Endereço:Center of Research and Development on Life Sciences and Environmental Sciences, Harbin University of Commerce, Harbin 150076, P.R. China.
[Ti] Título:Antioxidant and antitumor activities of Capparis spinosa L. and the related mechanisms.
[So] Source:Oncol Rep;37(1):357-367, 2017 Jan.
[Is] ISSN:1791-2431
[Cp] País de publicação:Greece
[La] Idioma:eng
[Ab] Resumo:The 'ethnodrug' Capparis spinosa L. has several pharmacological activities. First, it was found in previous experiments that an ethyl acetate extract of Capparis spinosa L. (CSE) exhibited antioxidant activity. In order to further research this finding, the present study investigate the blood biochemical indices, injury, energy metabolism, oxidative damage and mitochondrial membrane potential (Δψm) level of cardiac cells to study the effect of CSE on doxorubicin-induced cardiac toxicity. CSE had protective effects on the cardiac toxic effect of doxorubicin, and decreased the activity of lactic dehydrogenase (LDH) and creatine kinase (CK). CSE increased the ability of myocardial tissue to scavenge free radicals, inhibited lipid peroxidation, increased recovery activity of antioxidant enzymes, adjusted the energy metabolism of myocardial tissue, inhibited the generation of a large number of ROS in the cells, raised the level of Δψm, and improved the metabolism of free radicals. CSE demonstrated protective effects on doxorubicin-induced myocardial damage. Second, the quaternary ammonium hydroxide of Capparis spinosa L. (CSQAH) was found to possess antitumor activity, such as antiproliferative and apoptosis-induced effects on HepG2 cells. We investigated the regulatory mechanism of HepG2 apoptosis induced by CSQAH. Laser scanning confocal microscope and Fluo-3/AM staining were utilized to detect the Ca2+ concentration in the HepG2 cells. A microplate reader was used to measure the changes in Ca2+-Mg2+-ATP enzyme. Then, flow cytometry was applied to analyze the activity of ROS and the expression levels of Bcl-2 and Bax. As a result, different concentrations of CSQAH increased the concentration of Ca2+ in the cytoplasm in a dosage-dependent manner. CSQAH decreased the Ca2+­Mg2+­ATPase activity in the HepG2 cells. The levels of ROS in the CSQAH groups were significantly higher than the level in the control group. Flow cytometric analysis showed that the Bcl-2 expression levels in the CSQAH-treated groups were downregulated, while Bax expression levels were upregulated, and the effects were dosage-dependent. The regulatory mechanism of HepG2 cell apoptosis induced by CSQAH involved the increase in Ca2+ concentration and ROS levels, a decrease in Ca2+-Mg2+-ATPase activity in the HepG2 cells, and downregulation of anti-apoptotic Bcl-2 expression, and upregulation of apoptotic Bax expression. In summary, the present study demonstrated the antioxidant and antitumor activities of CSE which may suppress tumor growth and alleviate the side-effects of DOX, which may facilitate tumor treatment in a dual manner.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/farmacologia
Antioxidantes/farmacologia
Capparis/química
Doxorrubicina/efeitos adversos
[Mh] Termos MeSH secundário: Animais
Apoptose/efeitos dos fármacos
ATPase de Ca(2+) e Mg(2+)/metabolismo
Avaliação Pré-Clínica de Medicamentos/métodos
Feminino
Células Hep G2/efeitos dos fármacos
Seres Humanos
Masculino
Camundongos
Miócitos Cardíacos/efeitos dos fármacos
Miócitos Cardíacos/metabolismo
Miócitos Cardíacos/patologia
Substâncias Protetoras/farmacologia
Espécies Reativas de Oxigênio/metabolismo
Proteína X Associada a bcl-2/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Antioxidants); 0 (BAX protein, human); 0 (Protective Agents); 0 (Reactive Oxygen Species); 0 (bcl-2-Associated X Protein); 80168379AG (Doxorubicin); EC 3.6.1.- (Ca(2+) Mg(2+)-ATPase)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170322
[Lr] Data última revisão:
170322
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161124
[St] Status:MEDLINE
[do] DOI:10.3892/or.2016.5249


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[PMID]:27865953
[Au] Autor:Mazarei F; Jooyandeh H; Noshad M; Hojjati M
[Ad] Endereço:M.Sc. in Food Science and Technology, Faculty of Animal Science and Food Technology, Ramin Agriculture and Natural Resources University of Khuzestan, Mollasani, Khuzestan, Iran.
[Ti] Título:Polysaccharide of caper (Capparis spinosa L.) Leaf: Extraction optimization, antioxidant potential and antimicrobial activity.
[So] Source:Int J Biol Macromol;95:224-231, 2017 Feb.
[Is] ISSN:1879-0003
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Three-variable-three-level Box-Behnken design-response surface methodology (BBD-RSM) based on the single-factor experiments was used to optimize the extracting parameters of crude polysaccharides (CPSs) from the Capparis spinosa leaves (CSL) including extraction time (ETi, 60-120min), extraction temperature (ETe, 60-80°C), and the water/solid ratio (W/S, 6-16). The optimal process conditions in order to the highest yield (6.73%) of CSL-CPSs were 119.8min ETi, 72.84°C ETe, and 15.97:1W/S.Structure of polysaccharide extracted at the optimal operating point were identified by Fourier transform-infrared spectroscopy (FT-IR). CSL-CPSs (50-300µg/L) revealed significantly scavenging activities against 2,2-diphenyl-1-picrylhydrazyl (DPPH)and OH free-radicals in vitro. A much more antimicrobial activity using this polysaccharide against Gram-negative bacteria (Escherichia coli, Shigella dysenteriaeandSalmonella typhi) was found than Gram-positive bacteria (Bacillus panis and Staphylococcus aureus). CSL-CPSs can thus be used as anexcellent antioxidant and antimicrobial ingredient in food and medicinal preparations.
[Mh] Termos MeSH primário: Capparis/química
Fracionamento Químico/métodos
Folhas de Planta/química
Polissacarídeos/isolamento & purificação
Polissacarídeos/farmacologia
[Mh] Termos MeSH secundário: Antibacterianos/química
Antibacterianos/isolamento & purificação
Antibacterianos/farmacologia
Antioxidantes/química
Antioxidantes/isolamento & purificação
Antioxidantes/farmacologia
Bactérias/efeitos dos fármacos
Polissacarídeos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Antioxidants); 0 (Polysaccharides)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170403
[Lr] Data última revisão:
170403
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161121
[St] Status:MEDLINE


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[PMID]:27810780
[Au] Autor:Jalali MT; Mohammadtaghvaei N; Larky DA
[Ad] Endereço:Hyperlipidemia Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran; Diabetes Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
[Ti] Título:Investigating the effects of Capparis Spinosa on hepatic gluconeogenesis and lipid content in streptozotocin-induced diabetic rats.
[So] Source:Biomed Pharmacother;84:1243-1248, 2016 Dec.
[Is] ISSN:1950-6007
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:The present study aimed to investigate the effects of administration of Capparis spinosa (CS) fruit aqueous extract on liver metabolism in streptozotocin (STZ)-induced diabetic rats. The aqueous extract of CS was orally administered at a dose of 20mg/kg for 28 consecutive days and then its effects on blood glucose, lipid and insulin levels in normal and STZ diabetic rats were comparatively investigated. Furthermore, the effects of CS on the activity and expression of the key enzymes of gluconeogenesis and hepatic lipid content were investigated. The results showed that administration of CS extract in the STZ diabetic rats significantly decreased blood glucose level, while no significant influence on the insulin level. In addition, CS significantly decreased blood and liver triglyceride and cholesterol content in STZ diabetic rats. Furthermore, CS administration significantly reduced the mRNA expression and enzyme activities of glucose-6- phosphatase and phosphoenolpyruvate carboxykinase in liver tissues. Our findings demonstrated the beneficial effects of CS on blood glucose and lipid levels in an insulin- independent manner. This study also showed that CS improved the circulating levels of triglyceride and cholesterol. In addition, direct inhibition of gluconeogenesis in liver may be a probable mechanism of action of this plant. Since CS also decreased liver lipid content, we suggest that CS administration might be a beneficial therapeutic approach for metabolic syndrome and fatty liver.
[Mh] Termos MeSH primário: Capparis/química
Diabetes Mellitus Experimental/sangue
Diabetes Mellitus Experimental/tratamento farmacológico
Gluconeogênese
Lipídeos/sangue
Fígado/metabolismo
Extratos Vegetais/uso terapêutico
[Mh] Termos MeSH secundário: Animais
Glicemia/metabolismo
Jejum/sangue
Frutas/química
Gluconeogênese/efeitos dos fármacos
Glucose-6-Fosfatase/genética
Glucose-6-Fosfatase/metabolismo
Insulina/sangue
Fígado/efeitos dos fármacos
Fígado/enzimologia
Fígado/patologia
Masculino
Fosfoenolpiruvato Carboxiquinase (ATP)/metabolismo
Extratos Vegetais/farmacologia
RNA Mensageiro/genética
RNA Mensageiro/metabolismo
Ratos Wistar
Estreptozocina
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Blood Glucose); 0 (Insulin); 0 (Lipids); 0 (Plant Extracts); 0 (RNA, Messenger); 5W494URQ81 (Streptozocin); EC 3.1.3.9 (Glucose-6-Phosphatase); EC 4.1.1.49 (Phosphoenolpyruvate Carboxykinase (ATP))
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170921
[Lr] Data última revisão:
170921
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161105
[St] Status:MEDLINE


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[PMID]:27697367
[Au] Autor:Aichi-Yousfi H; Bahri BA; Medini M; Rouz S; Nejib Rejeb M; Ghrabi-Gammar Z
[Ad] Endereço:Tunisian National Institute of Agronomy, University of Carthage, 43, avenue Charles-Nicolle, Mahrajène, 1082 Tunis, Tunisia; Unit of research Bicade: Biogeography, Bioclimatology applied and erosive Dynamics, Faculty of Arts and Humanities of Mannouba, Mannouba, Tunisia.
[Ti] Título:Genetic diversity and population structure of six species of Capparis in Tunisia using AFLP markers.
[So] Source:C R Biol;339(11-12):442-453, 2016 Nov - Dec.
[Is] ISSN:1768-3238
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:In order to study the genetic diversity, the phylogeographic pattern and hybridization between six Tunisian Capparis species, 213 accessions of Caper were genotyped with three primer combinations of amplified fragment length polymorphism (AFLP) markers. Out of 750 fragments generated, 636 were polymorphic and 407 of them were restricted to a single species. STRUCTURE and PCoA analyses clearly separated morphologically different populations into six distinct genetic ones. The UPGMA analysis grouped the species into three main clusters: G1 grouped C. spinosa subsp. spinosa var. spinosa and C. sicula subsp. sicula; G2 grouped C. ovata subsp. ovata and C. orientalis and G3 clustered C. zoharyi and C. aegyptia. Populations from G1, G2 and G3 were mainly distributed in arid, subhumid, and semi-arid bioclimates, respectively. Additional genetic studies on Capparis could help to identify genes underlying speciation events and local adaptation to geographic areas leading to the development of breeding programs.
[Mh] Termos MeSH primário: Capparis/genética
Variação Genética/genética
[Mh] Termos MeSH secundário: Análise do Polimorfismo de Comprimento de Fragmentos Amplificados
Capparis/classificação
Clima
DNA de Plantas/genética
Marcadores Genéticos/genética
Genótipo
Geografia
Filogenia
População
Especificidade da Espécie
Tunísia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Plant); 0 (Genetic Markers)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170320
[Lr] Data última revisão:
170320
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161005
[St] Status:MEDLINE


  10 / 132 MEDLINE  
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[PMID]:27647009
[Au] Autor:Maresca M; Micheli L; Di Cesare Mannelli L; Tenci B; Innocenti M; Khatib M; Mulinacci N; Ghelardini C
[Ad] Endereço:Department of Neuroscience, Psychology, Drug Research and Child Health - NEUROFARBA - Pharmacology and Toxicology Section, University of Florence, Florence, Italy.
[Ti] Título:Acute effect of Capparis spinosa root extracts on rat articular pain.
[So] Source:J Ethnopharmacol;193:456-465, 2016 Dec 04.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:ETHNOPHARMACOLOGICAL RELEVANCE: Capparis spinosa L. originates from dry regions of Asia and Mediterranean basin. In traditional medicine of these areas, infusions from caper root are considered to be beneficial for the treatment of rheumatism, gout and against abdominal pains. AIM OF THE STUDY: To evaluate the pain relieving properties of a Syrian cultivar of Capparis spinosa roots in rat models of osteoarthritis and rheumatoid arthritis. MATERIALS AND METHODS: Decoction (DEC) and hydroalcoholic extract (EtH O) were obtained from powdered roots; the latter was further separated in CH Cl and aqueous (H O-Res) fractions. The extracts were characterized in terms of spermidine alkaloids by HPLC/DAD/MS and stachydrine by NMR. Different amount of free and glycosilated forms of capparispine and analogues (from 0.5% w/w for DEC up to 7.6% w/w for CH Cl fraction) were detected. Rat models of rheumatoid arthritis and osteoarthritis were induced by the intra-articular administration of Complete Freund's Adjuvant (CFA) or monosodium iodoacetate (MIA), respectively. RESULTS: Fourteenth days after CFA or MIA injection, the different preparations of Capparis spinosa (3, 30, 100 and 300mgkg ) were acutely administered p.o.. Powdered roots (300mgkg ), DEC (100mgkg ), and EtH O (300mgkg ) significantly reduced hypersensitivity to mechanical noxious stimuli as well as spontaneous pain evaluated as hind limb bearing alterations in both models. The CH Cl and the H O-Res (30mgkg ) were the most potent in reverting pain threshold alterations despite the different content of free alkaloids. CONCLUSIONS: Capparis spinosa extracts relieved pain related to rheumatoid arthritis and osteoarthritis after single administration. A synergistic effect due to a specific "phytochemical mixture" is suggested.
[Mh] Termos MeSH primário: Analgésicos/farmacologia
Artrite Experimental/tratamento farmacológico
Artrite Reumatoide/tratamento farmacológico
Capparis/química
Hiperalgesia/tratamento farmacológico
Osteoartrite/tratamento farmacológico
Limiar da Dor/efeitos dos fármacos
Extratos Vegetais/farmacologia
Raízes de Plantas/química
[Mh] Termos MeSH secundário: Administração Oral
Alcaloides/isolamento & purificação
Alcaloides/farmacologia
Analgésicos/administração & dosagem
Analgésicos/isolamento & purificação
Animais
Artrite Experimental/induzido quimicamente
Artrite Experimental/fisiopatologia
Artrite Experimental/psicologia
Artrite Reumatoide/induzido quimicamente
Artrite Reumatoide/fisiopatologia
Artrite Reumatoide/psicologia
Comportamento Animal/efeitos dos fármacos
Cromatografia Líquida de Alta Pressão
Relação Dose-Resposta a Droga
Adjuvante de Freund
Hiperalgesia/induzido quimicamente
Hiperalgesia/fisiopatologia
Hiperalgesia/psicologia
Ácido Iodoacético
Masculino
Osteoartrite/induzido quimicamente
Osteoartrite/fisiopatologia
Medição da Dor
Fitoterapia
Extratos Vegetais/administração & dosagem
Extratos Vegetais/isolamento & purificação
Plantas Medicinais
Espectroscopia de Prótons por Ressonância Magnética
Ratos Sprague-Dawley
Solventes/química
Espectrometria de Massas por Ionização por Electrospray
Espectrometria de Massas em Tandem
Fatores de Tempo
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Alkaloids); 0 (Analgesics); 0 (Plant Extracts); 0 (Solvents); 9007-81-2 (Freund's Adjuvant); WF5188V710 (Iodoacetic Acid)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170417
[Lr] Data última revisão:
170417
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160921
[St] Status:MEDLINE



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