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Pesquisa : B01.650.940.800.575.912.250.198.500.050 [Categoria DeCS]
Referências encontradas : 118 [refinar]
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[PMID]:28241734
[Au] Autor:Ryuk JA; Ko BS; Lee HW; Kim DS; Kang S; Lee YH; Park S
[Ad] Endereço:1 Korea Institute of Oriental Medicine, Daejeon 305-811, Korea.
[Ti] Título:Tetragonia tetragonioides (Pall.) Kuntze protects estrogen-deficient rats against disturbances of energy and glucose metabolism and decreases proinflammatory cytokines.
[So] Source:Exp Biol Med (Maywood);242(6):593-605, 2017 Mar.
[Is] ISSN:1535-3699
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Tetragonia tetragonioides (Pall.) Kuntze (TTK) and JakYakGamCho-Tang (JGT) have been used for improving women's health and treating inflammatory diseases. We determined that the long-term consumption of these herbal extracts alleviates the progression of postmenopausal symptoms in high-fat-diet fed ovariectomized (OVX) rats, and further explored the mechanisms involved. Five groups of OVX rats were fed high fat diets that were supplemented with either 2% dextrin (control), 2% TTK (70% ethanol extract), 2% JGT (water extract), 1% JGT + 1% TTK (JGTT), or 30 µg/kg body weight/day of 17ß-estradiol (positive control). After eight weeks of dietary intervention, the herbal treatments did not change the serum concentrations of 17ß-estradiol or uterine weight in control rats, but they were higher in the positive-control group. TTK rats exhibited higher daily energy expenditure, particularly fat oxidation, without modifying the energy intake than the controls. TTK lowered the fat mass but lean body mass of the abdomen and leg were increased. JGT decreased periuterine fat mass and lean body mass more than the control but the decrease was not as much as TTK. TTK resulted in substantially lower serum concentrations of the proinflammatory cytokines, tumor necrosis factor-α (TNF-α) and monocyte chemoattractant protein-1, than the control and JGT had lesser effect than TTK. Insulin resistance, determined by homeostasis model assessment estimate for assessing insulin resistance (HOMA-IR) and insulin tolerance test, was reduced in the decreasing order of control, JGT, JGTT, and TTK and the HOMA-IR of TTK was similar to the positive control. TTK, but not JGT, enhanced glucose tolerance compared with the control, although the serum insulin levels in TTK were lower compared to the control. Interestingly, the ß-cell masses were much greater in the TTK and JGTT groups than in the control, and they were comparable to the positive control. The increases in ß-cell masses in TTK and JGTT groups were associated with enhanced ß-cell proliferation and suppressed apoptosis, which was related to the decreased TNF-α and interleukin-1ß expressions. In conclusion, JGTT did not improve menopausal symptoms better than TTK itself. TTK itself prevented the OVX-induced impairments in energy, lipid, and glucose metabolism, similar to the positive control, without changing serum 17ß-estradiol levels and potentiating insulin signaling and decreasing proinflammatory cytokines. TTK may be a useful intervention to alleviate some menopausal symptoms similar to selective estrogen receptor modulators and should be investigated with further human study. Impact statement Menopause decreases the quality of life in middle-aged women and herbal remedies are sometimes used as alternatives for hormone replacement therapy, which may have detrimental side effects. Although several herbal extracts have been studied, no remedies improve all the menopausal symptoms. In this study, the 70% ethanol extract of Tetragonia tetragonioides (Pall.) Kuntze (TTK) reduced the symptoms of hot flushes and improved energy, glucose, and lipid metabolism in estrogen-deficient animals without increasing serum 17ß-estradiol levels. This extract acts like a selective estrogen receptor modulator and it may be a useful intervention for alleviating menopausal symptoms. This is the first study to show that the 70% ethanol extract of TTK has the potential to treat menopause-associated symptoms and metabolic disturbances. It may be a useful intervention for alleviating the symptoms of menopause in women if its efficacy can be confirmed in human studies.
[Mh] Termos MeSH primário: Aizoaceae
Metabolismo Energético/efeitos dos fármacos
Estrogênios/deficiência
Transtornos do Metabolismo de Glucose/tratamento farmacológico
Fitoterapia/métodos
Extratos Vegetais/uso terapêutico
[Mh] Termos MeSH secundário: Aizoaceae/química
Animais
Calorimetria
Metabolismo Energético/fisiologia
Feminino
Transtornos do Metabolismo de Glucose/etiologia
Ovariectomia
Ratos
Ratos Sprague-Dawley
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Estrogens); 0 (Plant Extracts)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171122
[Lr] Data última revisão:
171122
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170301
[St] Status:MEDLINE
[do] DOI:10.1177/1535370216683835


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[PMID]:28064427
[Au] Autor:Meddeb E; Charni M; Ghazouani T; Cozzolino A; Fratianni F; Raboudi F; Nazzaro F; Fattouch S
[Ad] Endereço:Laboratory of Protein Engineering and Bioactive-Molecules (LIP-MB), National Institute of Applied Sciences and Technology (INSAT), University of Carthage, Zone Urbaine Nord, 1080, Tunis, Tunisia. Emna.Meddeb@fsb.rnu.tn.
[Ti] Título:Biochemical and Molecular Study of Carpobrotus edulis Bioactive Properties and Their Effects on Dugesia sicula (Turbellaria, Tricladida) Regeneration.
[So] Source:Appl Biochem Biotechnol;182(3):1131-1143, 2017 Jul.
[Is] ISSN:1559-0291
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The traditional medicinal properties of Carpobrotus edulis are well recognized, particularly in Tunisia where it is used for wound healing. Thus, in this study, biochemical and molecular properties of its leaves' bioactive aqueous-acetone extract were investigated. The total phenolic content (TPC) of the extract was estimated to be 184 ± 5 mg/100 g of fresh matter (FM). The qualitative and quantitative polyphenolic profile was determined by ultra performance liquid chromatography with diode array detection (UPLC-DAD) and showed that chlorogenic acid was the major compound (43.7%). The extract exhibits potent antioxidant capacities with IC50 = 56.19 and 58.91 µg/ml, as accessed via the anionic DPPH and cationic ABTS radical scavenging assays, respectively. The extract has high antibacterial properties, especially against the Gram+ Staphylococcus aureus and Bacillus cereus strains. To investigate the extract effect on regeneration, the flatworm Dugesia sicula Lepori, 1948, was used as a model. The macroscopic analysis of planarian cultures in ordinary medium containing phenolic extract at non-toxic concentrations illustrated that the extract caused morphological changes. Additionally, the molecular study through the fluorescence-activated cell sorting (FACS) technique showed that C. edulis polyphenols can harm the stem cells' development. These results emphasize the ecotoxicological impact of phenolic rejections in the environment on flatworms' physiology.
[Mh] Termos MeSH primário: Aizoaceae/química
Antibacterianos/farmacologia
Planárias/fisiologia
Extratos Vegetais/farmacologia
Polifenóis/farmacologia
Regeneração/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Antibacterianos/química
Bacillus cereus/crescimento & desenvolvimento
Extratos Vegetais/química
Polifenóis/química
Staphylococcus aureus/crescimento & desenvolvimento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Plant Extracts); 0 (Polyphenols)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170626
[Lr] Data última revisão:
170626
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170109
[St] Status:MEDLINE
[do] DOI:10.1007/s12010-016-2387-y


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[PMID]:28038419
[Au] Autor:Mnasri M; Janousková M; Rydlová J; Abdelly C; Ghnaya T
[Ad] Endereço:Laboratoire des Plantes Extremophiles (LPE), Centre de Biotechnologies de la Technopole de Borj Cedria, BP 901, Hammam Lif, 2050, Tunisia; Université de Tunis El Manar, Tunisia; Institute of Botany, The Czech Academy of Sciences, Zámek 1, 252 43, Pruhonice, Czechia.
[Ti] Título:Comparison of arbuscular mycorrhizal fungal effects on the heavy metal uptake of a host and a non-host plant species in contact with extraradical mycelial network.
[So] Source:Chemosphere;171:476-484, 2017 Mar.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The effects of inoculation with an arbuscular mycorrhizal (AM) fungus on Cd and Ni tolerance and uptake in Medicago sativa, an AM host, and Sesuvium portulacastrum, a non-host plant, were investigated in a greenhouse experiment. The plants were cultivated in sterilized sand in a two-compartmented system, which prevented root competition but enabled colonization of the whole substrate by AM fungal extraradical mycelium. M. sativa was either left non-inoculated or inoculated with the AM fungus Rhizophagus irregularis, and both plants were either cultivated without heavy metal (HM) addition or supplied with cadmium (Cd) or nickel (Ni), each in two doses. Additional pots with singly cultivated plants were established to control for the effect of the co-cultivation. AM significantly enhanced the growth of M. sativa and substantially increased its uptake of both HMs. The roots of S. portulacastrum became colonized by AM fungal hyphae and vesicles. The presence of the AM fungus in the cultivation system tended to increase the HM uptake of S. portulacastrum, but the effect was less consistent and pronounced than that in M. sativa. We conclude that AM fungal mycelium radiating from M. sativa did not negatively affect the growth and HM uptake of S. portulacastrum. On the contrary, we hypothesize that it stimulated the absorption and translocation of Cd and Ni in the non-host species. Thus, our results suggest that AM fungal mycelium radiating from mycorrhizal plants does not decrease the HM uptake of non-host plants, many of which are considered promising candidate plants for phytoremediation.
[Mh] Termos MeSH primário: Aizoaceae
Cádmio/metabolismo
Glomeromycota/fisiologia
Medicago sativa
Micélio/fisiologia
Micorrizas/fisiologia
Níquel/metabolismo
[Mh] Termos MeSH secundário: Aizoaceae/metabolismo
Aizoaceae/microbiologia
Medicago sativa/metabolismo
Medicago sativa/microbiologia
Raízes de Plantas/metabolismo
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
00BH33GNGH (Cadmium); 7OV03QG267 (Nickel)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170427
[Lr] Data última revisão:
170427
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161231
[St] Status:MEDLINE


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[PMID]:27998816
[Au] Autor:Klak C; Hanácek P; Bruyns PV
[Ad] Endereço:Bolus Herbarium, Department of Biological Sciences, University of Cape Town, 7701 Rondebosch, South Africa. Electronic address: Cornelia.Klak@uct.ac.za.
[Ti] Título:Out of southern Africa: Origin, biogeography and age of the Aizooideae (Aizoaceae).
[So] Source:Mol Phylogenet Evol;109:203-216, 2017 Apr.
[Is] ISSN:1095-9513
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The Aizooideae is an early-diverging lineage within the Aizoaceae. It is most diverse in southern Africa, but also has endemic species in Australasia, Eurasia and South America. We derived a phylogenetic hypothesis from Bayesian and Maximum Likelihood analyses of plastid DNA-sequences. We find that one of the seven genera, the fynbos-endemic Acrosanthes, does not belong to the Aizooideae, but is an ancient sister-lineage to the subfamilies Mesembryanthemoideae & Ruschioideae. Galenia and Plinthus are embedded inside Aizoon and Aizoanthemum is polyphyletic. The Namibian endemic Tetragonia schenckii is sister to Tribulocarpus of the Sesuvioideae. For the Aizooideae, we explored their possible age by means of relaxed Bayesian dating and used Bayesian Binary MCMC reconstruction of ancestral areas to investigate their area of origin. Early diversification occurred in southern Africa in the Eocene-Oligocene, with a split into a mainly African lineage and an Eurasian-Australasian-African-South American lineage. These subsequently radiated in the early Miocene. For Tetragonia, colonisation of Australasia via long-distance dispersal from Eurasia gave rise to the Australasian lineage from which there were subsequent dispersals to South America and Southern Africa. Despite the relatively old age of the Aizooideae, more than half the species have radiated since the Pleiocene, coinciding with the large and rapid diversification of the Ruschioideae. The lineage made up of Tetragonia schenckii &Tribulocarpus split from the remainder of the Sesuvioideae already in the mid Oligocene and its disjunct distribution between Namibia and north-east Africa may be the result of a previously wider distribution within an early Arid African flora. Our reconstruction of ancestral character-states indicates that the expanding keels giving rise to hygrochastic fruits originated only once, i.e. after the split of the Sesuvioideae from the remainder of the Aizoaceae and that they were subsequently lost many times. Variously winged and spiky fruits, adapted to dispersal by wind and animals, have evolved independently in the Aizooideae and the Sesuvioideae. There is then a greater diversity of dispersal systems in the earlier lineages than in the Mesembryanthemoideae and Ruschioideae, where dispersal is mainly achieved by rain.
[Mh] Termos MeSH primário: Aizoaceae/classificação
Filogenia
Filogeografia
[Mh] Termos MeSH secundário: África Austral
Aizoaceae/genética
Animais
Teorema de Bayes
Frutas/anatomia & histologia
Variação Genética
Especificidade da Espécie
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170929
[Lr] Data última revisão:
170929
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161222
[St] Status:MEDLINE


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[PMID]:27939420
[Au] Autor:Krstenansky JL
[Ad] Endereço:KGI School of Pharmacy, 535 Watson Dr., Claremont, CA 91711, USA. Electronic address: John_Krstenansky@kgi.edu.
[Ti] Título:Mesembrine alkaloids: Review of their occurrence, chemistry, and pharmacology.
[So] Source:J Ethnopharmacol;195:10-19, 2017 Jan 04.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:ETHNOPHARMACOLOGICAL RELEVANCE: Mesembrine alkaloids are considered to be the primary active constituents of the South African medicinal plant Sceletium tortuosum (L.) N.E.Br. (Aizoaceae), and it is used as the dried or fermented aerial material from the plant, which is known as kanna (aka, channa, kougoed). Traditional regional use ranged from relieving thirst, mild analgesia, and alteration of mood. Current interest has focused primarily on the antidepressant action of preparations based on the plant and commercialization is expanding the recognition and availability of these preparations. MATERIALS AND METHODS: Searches for the keywords "Sceletium or mesembrine" were performed in "PubMed-NCBI", "Chemical Abstracts SciFinder" and "Thomson Reuters Web of Science" databases in addition to the inclusion of references cited within prior reviews and scientific reports. Additionally the "SciFinder" database was searched using 3a-phenyl-cis-octahydroindole in the SciFinder Substructure Module (SSM). Plant taxonomy was validated by the database "The Plant List". RESULTS: This review focuses on the chemistry, analysis, and pharmacology of the mesembrine alkaloids. Despite a long history of medicinal used and research investigation, there has been a renewed interest in the pharmacological properties of the mesembrine alkaloids and much of the pharmacology has only recently been published. The two major active alkaloids mesembrine and mesembrenone are still in the process of being more fully characterized pharmacologically. They are serotonin reuptake inhibitors, which provides a rationale for the plant's traditional use as an antidepressant, but other actions are beginning to appear in the literature. Additionally, mesembrenone has reasonably potent PDE4 inhibitory activity. This review intends to provide an overview of the available literature, summarize the current findings, and put them in perspective with earlier studies and reviews.
[Mh] Termos MeSH primário: Aizoaceae/química
Antidepressivos/farmacologia
Alcaloides de Indol/farmacologia
Inibidores da Fosfodiesterase 4/farmacologia
Inibidores da Captação de Serotonina/farmacologia
[Mh] Termos MeSH secundário: Animais
Antidepressivos/química
Antidepressivos/isolamento & purificação
Antidepressivos/toxicidade
Seres Humanos
Alcaloides de Indol/química
Alcaloides de Indol/isolamento & purificação
Alcaloides de Indol/toxicidade
Estrutura Molecular
Inibidores da Fosfodiesterase 4/química
Inibidores da Fosfodiesterase 4/isolamento & purificação
Inibidores da Fosfodiesterase 4/toxicidade
Fitoterapia
Plantas Medicinais
Inibidores da Captação de Serotonina/química
Inibidores da Captação de Serotonina/isolamento & purificação
Inibidores da Captação de Serotonina/toxicidade
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Antidepressive Agents); 0 (Indole Alkaloids); 0 (Phosphodiesterase 4 Inhibitors); 0 (Serotonin Uptake Inhibitors); 86E2ZU4ETY (mesembrine)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170703
[Lr] Data última revisão:
170703
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161213
[St] Status:MEDLINE


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[PMID]:27561908
[Au] Autor:Noshita T; Matsumoto K; Nishikawa H; Ouchi H; Hamada Y; Saito A; Yamada T
[Ad] Endereço:a Faculty of Life and Environmental Sciences, Department of Life Sciences , Prefectural University of Hiroshima , Shobara , Japan.
[Ti] Título:The structure proposed for apteniol D is different from that of the compound obtained by total synthesis.
[So] Source:Nat Prod Res;31(2):163-168, 2017 Jan.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:We describe the synthesis of 4,4'-oxyneolignan, the proposed structure for naturally occurring apteniol D. The diphenyl ether moiety in 4,4'-oxyneolignan was formed via classical Ullmann ether synthesis using excess copper powder in N,N-dimethylacetamide. The spectral data of synthesised apteniol D show differences compared to those of naturally occurring apteniol D.
[Mh] Termos MeSH primário: Concentração de Íons de Hidrogênio
Éteres Fenílicos/química
[Mh] Termos MeSH secundário: Aizoaceae/química
Éteres/química
Espectroscopia de Ressonância Magnética
Espectrometria de Massas
Espectrofotometria Infravermelho
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Ethers); 0 (Phenyl Ethers); 0 (apteniol D)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160827
[St] Status:MEDLINE


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[PMID]:27810674
[Au] Autor:Percey WJ; Shabala L; Wu Q; Su N; Breadmore MC; Guijt RM; Bose J; Shabala S
[Ad] Endereço:School of Land and Food, University of Tasmania, Hobart, Tas 7001, Australia.
[Ti] Título:Potassium retention in leaf mesophyll as an element of salinity tissue tolerance in halophytes.
[So] Source:Plant Physiol Biochem;109:346-354, 2016 Dec.
[Is] ISSN:1873-2690
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:Soil salinity remains a major threat to global food security, and the progress in crop breeding for salinity stress tolerance may be achieved only by pyramiding key traits mediating plant adaptive responses to high amounts of dissolved salts in the rhizosphere. This task may be facilitated by studying natural variation in salinity tolerance among plant species and, specifically, exploring mechanisms of salinity tolerance in halophytes. The aim of this work was to establish the causal link between mesophyll ion transport activity and plant salt tolerance in a range of evolutionary contrasting halophyte and glycophyte species. Plants were grown under saline conditions in a glasshouse, followed by assessing their growth and photosynthetic performance. In a parallel set of experiments, net K and H transport across leaf mesophyll and their modulation by light were studied in control and salt-treated mesophyll segments using vibrating non-invasive ion selective microelectrode (the MIFE) technique. The reported results show that mesophyll cells in glycophyte species loses 2-6 fold more K compared with their halophyte counterparts. This decline was reflected in a reduced maximum photochemical efficiency of photosystem II, chlorophyll content and growth observed in the glasshouse experiments. In addition to reduced K efflux, the more tolerant species also exhibited reduced H efflux, which is interpreted as an energy-saving strategy allowing more resources to be redirected towards plant growth. It is concluded that the ability of mesophyll to retain K without a need to activate plasma membrane H -ATPase is an essential component of salinity tolerance in halophytes and halophytic crop plants.
[Mh] Termos MeSH primário: Potássio/metabolismo
Plantas Tolerantes a Sal/metabolismo
[Mh] Termos MeSH secundário: Aizoaceae/metabolismo
Beta vulgaris/metabolismo
Chenopodium quinoa/metabolismo
Clorofila/metabolismo
Mesembryanthemum/metabolismo
Células do Mesofilo/metabolismo
Fotossíntese
Folhas de Planta/metabolismo
Salinidade
Tolerância a Sal/fisiologia
Especificidade da Espécie
Vicia faba/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
1406-65-1 (Chlorophyll); RWP5GA015D (Potassium)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170410
[Lr] Data última revisão:
170410
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161105
[St] Status:MEDLINE


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[PMID]:27714064
[Au] Autor:Jin Z
[Ad] Endereço:State Key Laboratory and Institute of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, China. zjin@nankai.edu.cn and Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin 300071, China.
[Ti] Título:Amaryllidaceae and Sceletium alkaloids.
[So] Source:Nat Prod Rep;33(11):1318-1343, 2016 Oct 26.
[Is] ISSN:1460-4752
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Covering: July 2012 to June 2015. Previous review: Nat. Prod. Rep., 2013, 30, 849-868The latest progress on the isolation, identification, biological activity and synthetic studies of the structurally diverse alkaloids from plants of family Amaryllidaceae has been summarized in this review. In addition, the structurally related alkaloids isolated from Sceletium species were discussed as well.
[Mh] Termos MeSH primário: Aizoaceae/química
Alcaloides de Amaryllidaceae/química
Plantas Medicinais/química
[Mh] Termos MeSH secundário: Estrutura Molecular
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Amaryllidaceae Alkaloids)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170523
[Lr] Data última revisão:
170523
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161008
[St] Status:MEDLINE


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[PMID]:27479784
[Au] Autor:Fourati E; Wali M; Vogel-Mikus K; Abdelly C; Ghnaya T
[Ad] Endereço:Université de Tunis El Manar, BP 901, 2050 Hammam-Lif, Tunisia; Centre de Biotechnologie de Borj Cedria (LR15CBBC02), Laboratoire des Plantes Extrèmophiles, BP 901, 2050 Hammam-Lif, Tunisia; Department of Biology, Biotechnical Faculty, University of Ljubljana, Jamnikarjeva 101, SI-1000 Ljubljana, Sl
[Ti] Título:Nickel tolerance, accumulation and subcellular distribution in the halophytes Sesuvium portulacastrum and Cakile maritima.
[So] Source:Plant Physiol Biochem;108:295-303, 2016 Nov.
[Is] ISSN:1873-2690
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:It has been shown that halophytes are able to successfully cope with heavy metal toxicity, suggesting their possible use for remediation of metal contaminated soils. In this work, Ni tolerance and accumulation in two halophytes, Sesuvium portulacastrum (L.) L. and Cakile maritima Scop. was investigated. Seedlings of both species were subjected hydroponically during 21 days to 0, 25, 50, and 100 µM of NiCl . The growth and photosynthesis parameters revealed that S. portulacastrum tolerates Ni better than C. maritima. The photosynthesis activity, chlorophyll content and photosystem II integrity were less impacted in Ni-treated S. portulacastrum as compared to C. maritima, although, Ni accumulated in higher concentrations in the shoots of S. portulacastrum (1050 µg g DW) than in those of C. maritima (550 µg g DW). The subcellular fractionation of Ni in the shoots of both species showed that C. maritima accumulated about 65% of Ni in the soluble fraction, while 28% was associated with the cell walls. In S. portulacastrum 44% of the total cellular Ni was seen in the soluble fraction and 43% was bound to the cell walls. It can be concluded that S. portulacastrum tolerates Ni better than C. maritima, most probably due to a better ability to sequester Ni in the cell walls, restricting its accumulation in the soluble fraction.
[Mh] Termos MeSH primário: Aizoaceae/efeitos dos fármacos
Brassicaceae/efeitos dos fármacos
Níquel/farmacocinética
Níquel/toxicidade
Plantas Tolerantes a Sal/efeitos dos fármacos
[Mh] Termos MeSH secundário: Aizoaceae/crescimento & desenvolvimento
Aizoaceae/metabolismo
Brassicaceae/crescimento & desenvolvimento
Brassicaceae/metabolismo
Carotenoides/metabolismo
Parede Celular/efeitos dos fármacos
Parede Celular/metabolismo
Clorofila/metabolismo
Fluorescência
Plantas Tolerantes a Sal/metabolismo
Especificidade da Espécie
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
1406-65-1 (Chlorophyll); 36-88-4 (Carotenoids); 7OV03QG267 (Nickel)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170813
[Lr] Data última revisão:
170813
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160802
[St] Status:MEDLINE


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[PMID]:27448766
[Au] Autor:Omanakuttan A; Bose C; Pandurangan N; Kumar GB; Banerji A; Nair BG
[Ad] Endereço:Amrita School of Biotechnology, Amrita Vishwa Vidyapeetham, Amritapuri, Clappana P.O, Kollam, Kerala 690525, India.
[Ti] Título:Nitric Oxide and ERK mediates regulation of cellular processes by Ecdysterone.
[So] Source:Exp Cell Res;346(2):167-75, 2016 Aug 15.
[Is] ISSN:1090-2422
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The complex process of wound healing is a major problem associated with diabetes, venous or arterial disease, old age and infection. A wide range of pharmacological effects including anabolic, anti-diabetic and hepato-protective activities have been attributed to Ecdysterone. In earlier studies, Ecdysterone has been shown to modulate eNOS and iNOS expression in diabetic animals and activate osteogenic differentiation through the Extracellular-signal-Regulated Kinase (ERK) pathway in periodontal ligament stem cells. However, in the wound healing process, Ecdysterone has only been shown to enhance granulation tissue formation in rabbits. There have been no studies to date, which elucidate the molecular mechanism underlying the complex cellular process involved in wound healing. The present study, demonstrates a novel interaction between the phytosteroid Ecdysterone and Nitric Oxide Synthase (NOS), in an Epidermal Growth Factor Receptor (EGFR)-dependent manner, thereby promoting cell proliferation, cell spreading and cell migration. These observations were further supported by the 4-amino-5-methylamino- 2' ,7' -difluorofluorescein diacetate (DAF FM) fluorescence assay which indicated that Ecdysterone activates NOS resulting in increased Nitric Oxide (NO) production. Additionally, studies with inhibitors of both the EGFR and ERK, demonstrated that Ecdysterone activates NOS through modulation of EGFR and ERK. These results clearly demonstrate, for the first time, that Ecdysterone enhances Nitric Oxide production and modulates complex cellular processes by activating ERK1/2 through the EGF pathway.
[Mh] Termos MeSH primário: Ecdisterona/farmacologia
MAP Quinases Reguladas por Sinal Extracelular/metabolismo
Óxido Nítrico/metabolismo
[Mh] Termos MeSH secundário: Células 3T3-L1
Aizoaceae/química
Animais
Ensaios de Migração Celular
Movimento Celular/efeitos dos fármacos
Proliferação Celular/efeitos dos fármacos
Ecdisterona/química
Ecdisterona/isolamento & purificação
Ativação Enzimática/efeitos dos fármacos
Flavonoides/farmacologia
Camundongos
Quinazolinas/farmacologia
Receptor do Fator de Crescimento Epidérmico/metabolismo
Transdução de Sinais/efeitos dos fármacos
Tirfostinas/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one); 0 (Flavonoids); 0 (Quinazolines); 0 (Tyrphostins); 170449-18-0 (tyrphostin AG 1478); 31C4KY9ESH (Nitric Oxide); 5289-74-7 (Ecdysterone); EC 2.7.10.1 (Receptor, Epidermal Growth Factor); EC 2.7.11.24 (Extracellular Signal-Regulated MAP Kinases)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170515
[Lr] Data última revisão:
170515
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160725
[St] Status:MEDLINE



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