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Pesquisa : B01.650.940.800.575.912.250.198.500.100 [Categoria DeCS]
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[PMID]:28743765
[Au] Autor:Kurmanbayeva A; Bekturova A; Srivastava S; Soltabayeva A; Asatryan A; Ventura Y; Khan MS; Salazar O; Fedoroff N; Sagi M
[Ad] Endereço:Plant Stress Laboratory, French Associates Institute for Agriculture and Biotechnology of Drylands, Blaustein Institutes for Desert Research, Ben-Gurion University of the Negev, 84990, Israel.
[Ti] Título:Higher Novel L-Cys Degradation Activity Results in Lower Organic-S and Biomass in than the Related Saltwort, .
[So] Source:Plant Physiol;175(1):272-289, 2017 Sep.
[Is] ISSN:1532-2548
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:and are almost identical halophytes whose edible succulent shoots hold promise for commercial production in saline water. Enhanced sulfur nutrition may be beneficial to crops naturally grown on high sulfate. However, little is known about sulfate nutrition in halophytes. Here we show that (ecotype RN) exhibits a significant increase in biomass and organic-S accumulation in response to supplemental sulfate, whereas (ecotype VM) does not, instead exhibiting increased sulfate accumulation. We investigated the role of two pathways on organic-S and biomass accumulation in and : the sulfate reductive pathway that generates Cys and l-Cys desulfhydrase that degrades Cys to H S, NH , and pyruvate. The major function of -acetyl-Ser-(thiol) lyase (OAS-TL; EC 2.5.1.47) is the formation of l-Cys, but our study shows that the OAS-TL A and OAS-TL B of both halophytes are enzymes that also degrade l-Cys to H S. This activity was significantly higher in than in , especially upon sulfate supplementation. The activity of the sulfate reductive pathway key enzyme, adenosine 5'-phosphosulfate reductase (APR, EC 1.8.99.2), was significantly higher in than in These results suggest that the low organic-S level in is the result of high l-Cys degradation rate by OAS-TLs, whereas the greater organic-S and biomass accumulation in is the result of higher APR activity and low l-Cys degradation rate, resulting in higher net Cys biosynthesis. These results present an initial road map for halophyte growers to attain better growth rates and nutritional value of and .
[Mh] Termos MeSH primário: Amaranthaceae/metabolismo
Chenopodiaceae/metabolismo
Cisteína/metabolismo
Proteínas de Plantas/metabolismo
Salsola/metabolismo
Enxofre/metabolismo
[Mh] Termos MeSH secundário: Amaranthaceae/efeitos dos fármacos
Biomassa
Chenopodiaceae/efeitos dos fármacos
Cisteína Sintase/metabolismo
Oxirredutases atuantes sobre Doadores de Grupo Enxofre/metabolismo
Salinidade
Salsola/efeitos dos fármacos
Plantas Tolerantes a Sal
Sódio/farmacologia
Sulfatos/farmacologia
Compostos de Sulfidrila/metabolismo
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Proteins); 0 (Sulfates); 0 (Sulfhydryl Compounds); 70FD1KFU70 (Sulfur); 9NEZ333N27 (Sodium); EC 1.8.- (Oxidoreductases Acting on Sulfur Group Donors); EC 1.8.99.2 (adenylylsulfate reductase); EC 2.5.1.47 (Cysteine Synthase); K848JZ4886 (Cysteine)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180226
[Lr] Data última revisão:
180226
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170727
[St] Status:MEDLINE
[do] DOI:10.1104/pp.17.00780


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[PMID]:29254300
[Au] Autor:Khalid M; Bilal M; Hassani D; Iqbal HMN; Huang D
[Ad] Endereço:School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, China.
[Ti] Título:Antimicrobial, antioxidant, cytotoxicity and LC-MS analyses of Aerva javanica: an ethnomedicinally important plant.
[So] Source:J Biol Regul Homeost Agents;31(4):963-969, 2017 Oct-Dec.
[Is] ISSN:0393-974X
[Cp] País de publicação:Italy
[La] Idioma:eng
[Ab] Resumo:In this study, Aerva javanica was used to extract the essential oil with notable medicinal activities. The chemical composition was investigated by high-performance liquid chromatography (HPLC) and liquid chromatography/mass spectrometry (LC-MS). Ten major chemical compounds were identified as flavonoids derivatives, dihydroxylated and glycosylated metabolites. The antimicrobial, antioxidant, and cytotoxicity activities were tested using agar well-diffusion assay, 1, 1-diphenyl-2-picrylhydrazyl (DPPH) free-radical scavenging and linoleic acid oxidation assays and hemolytic assay against human erythrocytes (RBCs), respectively. Plant extracts exhibited different extents of antimicrobial activities against selected bacterial and fungal strains; however, the essential oil displayed potent antimicrobial activity against all the tested strains. The percentage inhibition of linoleic acid oxidation and inhibitory concentration (IC50) were recorded to be in the range of 42.45-96.21% and 14.21-38.18 µg/mL, respectively. Cytotoxicity profile of A. javanica extracts and essential oil was found in the range of 5.82 to 14.47%. In conclusion, A. javanica essential oil could be a potential alternative to chemical additives in the food and pharmaceutical industries.
[Mh] Termos MeSH primário: Amaranthaceae/química
Anti-Infecciosos/farmacologia
Antioxidantes/farmacologia
Citotoxinas/farmacologia
Flavonoides/farmacologia
Óleos Voláteis/farmacologia
[Mh] Termos MeSH secundário: Anti-Infecciosos/isolamento & purificação
Antioxidantes/isolamento & purificação
Compostos de Bifenilo/antagonistas & inibidores
Compostos de Bifenilo/química
Citotoxinas/isolamento & purificação
Flavonoides/isolamento & purificação
Fungos/efeitos dos fármacos
Fungos/crescimento & desenvolvimento
Bactérias Gram-Negativas/efeitos dos fármacos
Bactérias Gram-Negativas/crescimento & desenvolvimento
Bactérias Gram-Positivas/efeitos dos fármacos
Bactérias Gram-Positivas/crescimento & desenvolvimento
Concentração Inibidora 50
Ácido Linoleico/química
Testes de Sensibilidade Microbiana
Óleos Voláteis/isolamento & purificação
Oxirredução
Picratos/antagonistas & inibidores
Picratos/química
Extratos Vegetais/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Infective Agents); 0 (Antioxidants); 0 (Biphenyl Compounds); 0 (Cytotoxins); 0 (Flavonoids); 0 (Oils, Volatile); 0 (Picrates); 0 (Plant Extracts); 9KJL21T0QJ (Linoleic Acid); DFD3H4VGDH (1,1-diphenyl-2-picrylhydrazyl)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180222
[Lr] Data última revisão:
180222
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171220
[St] Status:MEDLINE


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[PMID]:28454506
[Au] Autor:Pandey A; Kaushik A; Wanjari M; Dey YN; Jaiswal BS; Dhodi A
[Ad] Endereço:a Department of Pharmaceutical Sciences , IFTM University , Moradabad , India.
[Ti] Título:Antioxidant and anti-inflammatory activities of Aerva pseudotomentosa leaves.
[So] Source:Pharm Biol;55(1):1688-1697, 2017 12.
[Is] ISSN:1744-5116
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:CONTEXT: Aerva pseudotomentosa Blatt. & Hallb. (Amaranthaceae), commonly called "Bui";, is a medicinal plant of the arid region. It is used for the treatment of inflammatory disorders, such as rheumatic pain, and healing of wounds, which are associated with oxidative stress. OBJECTIVE: The present study evaluated the antioxidant potential of Aerva pseudotomentosa leaves by in vitro models and its anti-inflammatory effect in rats. MATERIAL AND METHODS: The aqueous extract (APAE) was analyzed by HPTLC and HPLC. The antioxidant effect of APAE was evaluated by various in vitro methods [DPPH (1, 1-diphenyl-2-picryl-hydrazil) and hydrogen peroxide free radical scavenging, reducing power, and anti-lipid peroxidation assays]. Anti-inflammatory effect was studied in carrageenan and formalin-induced paw oedema models in rats. APAE (200 and 400 mg/kg) and standard drug, indomethacin (10 mg/kg), were administered orally 1 h before carrageenan/formalin administration and inflammation was noted up to 5 h. RESULTS: HPLC analysis of APAE revealed the presence of rutin. APAE showed significant scavenging effect on DPPH (IC 49.37 µ g/mL) and peroxide (IC 288.2 µ g/mL) radicals. The extract exhibited reducing potential and inhibition of lipid peroxidation. APAE treatment significantly attenuated mean increase in paw volume and exhibited inhibition of paw oedema in both in vivo models with inhibition of 45.11% and 49.42%, respectively at 5 h. DISCUSSION AND CONCLUSION: APAE exhibited in vitro antioxidant and anti-inflammatory activities. Anti-inflammatory effect of APAE may be attributed to its antioxidant potential, due to the presence of rutin and other phenolics. This study substantiates folk use of leaves in inflammatory disorders.
[Mh] Termos MeSH primário: Amaranthaceae/química
Anti-Inflamatórios/farmacologia
Antioxidantes/farmacologia
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Animais
Anti-Inflamatórios/administração & dosagem
Anti-Inflamatórios/isolamento & purificação
Antioxidantes/administração & dosagem
Antioxidantes/isolamento & purificação
Cromatografia Líquida de Alta Pressão
Modelos Animais de Doenças
Relação Dose-Resposta a Droga
Edema/tratamento farmacológico
Edema/patologia
Feminino
Indometacina/farmacologia
Inflamação/tratamento farmacológico
Inflamação/patologia
Peroxidação de Lipídeos/efeitos dos fármacos
Masculino
Estresse Oxidativo/efeitos dos fármacos
Fenóis/isolamento & purificação
Fenóis/farmacologia
Folhas de Planta
Ratos
Ratos Wistar
Rutina/isolamento & purificação
Rutina/farmacologia
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Antioxidants); 0 (Phenols); 0 (Plant Extracts); 5G06TVY3R7 (Rutin); XXE1CET956 (Indomethacin)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:180212
[Lr] Data última revisão:
180212
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170430
[St] Status:MEDLINE
[do] DOI:10.1080/13880209.2017.1321022


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[PMID]:28857026
[Au] Autor:Lucena T; Arahal DR; Ruvira MA; Navarro-Torre S; Mesa J; Pajuelo E; Rodriguez-Llorente ID; Rodrigo-Torres L; Piñar MJ; Pujalte MJ
[Ad] Endereço:1​Departamento de Microbiología y Ecología & Colección Española de Cultivos Tipo (CECT), Universitat de València, Spain.
[Ti] Título:Vibrio palustris sp. nov. and Vibrio spartinae sp. nov., two novel members of the Gazogenes clade, isolated from salt-marsh plants (Arthrocnemum macrostachyum and Spartina maritima).
[So] Source:Int J Syst Evol Microbiol;67(9):3506-3512, 2017 Sep.
[Is] ISSN:1466-5034
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Two bacterial strains, EAod9T and SMJ21T, isolated from salt-marsh plants, were determined to be related to species of the genus Vibriofrom from 16S rRNA sequence comparisons. Their closest phylogenetic relatives are members of the Gazogenes clade, Vibrio mangrovi and Vibrio rhizosphaerae , which show the greatest similarity to the SMJ21TrRNA sequence (97.3 and 97.1 %, respectively), while EAod9T had less than 97.0 % similarity to any other species of the genus Vibrio. Both strains share the basic characteristics of the genus Vibrio, as they are Gram-stain negative, motile, slightly halophilic, facultatively anaerobic bacteria. In addition, they are oxidase-negative and unable to grow on TCBS Agar; they grow between 15 to 26 °C, pH 6 to 8 and in up to 10 % (w/v) total salinity. They produce indol, are positive in the Voges-Proskauer test and are negative for arginine dihydrolase, lysine and ornithine decarboxylases. Strain SMJ21T is aerogenic and red-pigmented, due to prodigiosin production, while strain EAod9T ferments glucose without gas and is not pigmented. The major cellular fatty acids of both novel strains were C16 : 1ω7c/C16 : 1ω6c and C16 : 0. WGSobtained for both strains, along with the other five members of the clade, allowed the determination of ANI indexes and in silico estimations of DDH values, which confirmed that the two strains represent two novel species of the genus Vibrio: Vibriopalustris sp. nov. (with EAod9T=CECT 9027T=LMG 29724T as the proposed type strain) and Vibrio spartinae sp. nov. (with SMJ21T=CECT 9026T=LMG 29723T as the proposed type strain).
[Mh] Termos MeSH primário: Amaranthaceae/microbiologia
Filogenia
Poaceae/microbiologia
Vibrio/classificação
Zonas Úmidas
[Mh] Termos MeSH secundário: Técnicas de Tipagem Bacteriana
Composição de Bases
DNA Bacteriano/genética
Ácidos Graxos/química
Pigmentação
RNA Ribossômico 16S/genética
Plantas Tolerantes a Sal/microbiologia
Análise de Sequência de DNA
Espanha
Vibrio/genética
Vibrio/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Bacterial); 0 (Fatty Acids); 0 (RNA, Ribosomal, 16S)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170920
[Lr] Data última revisão:
170920
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170901
[St] Status:MEDLINE
[do] DOI:10.1099/ijsem.0.002155


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[PMID]:28853694
[Au] Autor:Fidalgo C; Martins R; Proença DN; Morais PV; Alves A; Henriques I
[Ad] Endereço:1​Departamento de Biologia, CESAM, Universidade de Aveiro, Aveiro, Portugal.
[Ti] Título:Zunongwangia endophytica sp. nov., an endophyte isolated from the salt marsh plant, Halimione portulacoides, and emended description of the genus Zunongwangia.
[So] Source:Int J Syst Evol Microbiol;67(8):3004-3009, 2017 Aug.
[Is] ISSN:1466-5034
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Taxonomical analyses were performed on strain CPA58T, a novel isolate obtained from surface-sterilized aboveground tissues of the halophyte Halimione portulacoides, collected from a salt marsh in Ria de Aveiro, Portugal. The strain was Gram-stain-negative, rod-shaped, oxidase-negative and catalase-positive. Optimal growth was observed at 26 °C, at pH 6-8 and in the presence of 2 to 3 % (w/v) NaCl. Phylogenetic analyses, based on the 16S rRNA gene sequence, showed that strain CPA58T belongs to the genus Zunongwangia, with highest sequence similarities to both Zunongwangia profunda SM-A87T and Zunongwangia mangrovi P2E16T (96.5 %), followed by Zunongwangia atlantica 22II14-10F7T (95.9 %). The principal fatty acids were iso-C15 : 0, summed feature 3 (C16 : 1ω7c and/or iso-C15 : 0 2-OH) and iso-C17 : 0 3-OH. The major respiratory quinone was MK-6 and the DNA G+C content was 35.1 mol%. Phylogenetic and chemotaxonomic analyses clearly placed strain CPA58T in the genus Zunongwangia. However, 16S rRNA gene sequence analysis showed that the threshold for same species relatedness was not surpassed, and biochemical tests revealed diagnostic characteristics that differentiated this strain from other type strains of species of the genus Zunongwangia. Overall, the analyses showed that strain CPA58T represents a novel species within the genus Zunongwangia, for which the name Zunongwangia endophytica sp. nov. is proposed, with the type strain CPA58T (=CECT 9128T=LMG 29517T).
[Mh] Termos MeSH primário: Amaranthaceae/microbiologia
Flavobacteriaceae/classificação
Filogenia
Plantas Tolerantes a Sal/microbiologia
Zonas Úmidas
[Mh] Termos MeSH secundário: Técnicas de Tipagem Bacteriana
Composição de Bases
DNA Bacteriano/genética
Endófitos/classificação
Endófitos/genética
Endófitos/isolamento & purificação
Ácidos Graxos/química
Flavobacteriaceae/genética
Flavobacteriaceae/isolamento & purificação
Portugal
RNA Ribossômico 16S/genética
Análise de Sequência de DNA
Vitamina K 2/análogos & derivados
Vitamina K 2/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Bacterial); 0 (Fatty Acids); 0 (RNA, Ribosomal, 16S); 11032-49-8 (Vitamin K 2); 71ANL51TLA (menaquinone 6)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170918
[Lr] Data última revisão:
170918
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170831
[St] Status:MEDLINE
[do] DOI:10.1099/ijsem.0.002069


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[PMID]:28719623
[Au] Autor:Li C; Shi X; Mohamad OA; Gao J; Xu X; Xie Y
[Ad] Endereço:Department of National Engineering Technology Research Center for Desert-Oasis Ecological Construction, Xinjiang Institute of Ecology and Geography, Chinese Academy of Sciences, Urumqi, Xinjiang, China.
[Ti] Título:Moderate irrigation intervals facilitate establishment of two desert shrubs in the Taklimakan Desert Highway Shelterbelt in China.
[So] Source:PLoS One;12(7):e0180875, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Water influences various physiological and ecological processes of plants in different ecosystems, especially in desert ecosystems. The purpose of this study is to investigate the response of physiological and morphological acclimation of two shrubs Haloxylon ammodendron and Calligonum mongolicunl to variations in irrigation intervals. METHODOLOGY/PRINCIPAL FINDINGS: The irrigation frequency was set as 1-, 2-, 4-, 8- and 12-week intervals respectively from March to October during 2012-2014 to investigate the response of physiological and morphological acclimation of two desert shrubs Haloxylon ammodendron and Calligonum mongolicunl to variations in the irrigation system. The irrigation interval significantly affected the individual-scale carbon acquisition and biomass allocation pattern of both species. Under good water conditions (1- and 2-week intervals), carbon assimilation was significantly higher than other treatments; while, under water shortage conditions (8- and 12-week intervals), there was much defoliation; and under moderate irrigation intervals (4 weeks), the assimilative organs grew gently with almost no defoliation occurring. CONCLUSION/SIGNIFICANCE: Both studied species maintained similar ecophysiologically adaptive strategies, while C. mongolicunl was more sensitive to drought stress because of its shallow root system and preferential belowground allocation of resources. A moderate irrigation interval of 4 weeks was a suitable pattern for both plants since it not only saved water but also met the water demands of the plants.
[Mh] Termos MeSH primário: Irrigação Agrícola/métodos
Amaranthaceae/efeitos dos fármacos
Caryophyllaceae/efeitos dos fármacos
Clima Desértico
Água/farmacologia
[Mh] Termos MeSH secundário: Aclimatação
Amaranthaceae/crescimento & desenvolvimento
Amaranthaceae/metabolismo
Amaranthaceae/fisiologia
Biomassa
Caryophyllaceae/crescimento & desenvolvimento
Caryophyllaceae/fisiologia
China
Fotossíntese/efeitos dos fármacos
Folhas de Planta/efeitos dos fármacos
Folhas de Planta/crescimento & desenvolvimento
Folhas de Planta/metabolismo
Solo/química
Fatores de Tempo
Água/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Soil); 059QF0KO0R (Water)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170719
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0180875


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[PMID]:28699863
[Au] Autor:Liu L; Li L; Song Z; Wang S; Zhang J; Zhang X; Sun Q
[Ad] Endereço:1​State Key Laboratory of Tree Genetics and Breeding, Research Institute of Forestry, Chinese Academy of Forestry, Beijing 100091, PR China.
[Ti] Título:Parapedobacter deserti sp. nov., an endophytic bacterium isolated from Haloxylon ammodendron stems.
[So] Source:Int J Syst Evol Microbiol;67(7):2148-2152, 2017 Jul.
[Is] ISSN:1466-5034
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Strain N5SSJ16T, a Gram-negative-staining, non-spore-forming, rod-shaped, non-motile bacterium, was isolated from Haloxylon ammodendron stems. The strain grew in the presence of 0-4 % (w/v) NaCl (optimum growth in the absence of NaCl), at pH 7-9 (optimum: pH 8) and at 12-50 °C. Phylogenetic analysis based on 16S rRNA gene sequences showed that strain N5SSJ16T was related phylogenetically to Parapedobacter composti 4M40T (96.5 %) and Parapedobacter luteus 4M29T (95.9 %). The cellular fatty acids were iso-C15 : 0, summed feature 3 (C16 : 1ω7c and/or C16 : 1ω6c), summed feature 9 (C16 : 0 10-methyl and/or iso-C17 : 1ω9c) and iso-C17 : 0 3-OH. MK-7 was the respiratory quinone. The main polar lipids were phosphatidylethanolamine, unidentified aminophospholipid and two unknown lipids. The G+C content of the DNA was 45.8 mol%. On the basis of chemotaxonomic, phylogenetic and phenotypic evidence, strain N5SSJ16T represents a novel species of the genus Parapedobacter, for which the name Parapedobacter deserti sp. nov. is proposed. The type strain is N5SSJ16T (=ACCC 19928T=KCTC 52416T).
[Mh] Termos MeSH primário: Amaranthaceae/microbiologia
Bacteroidetes/classificação
Filogenia
Caules de Planta/microbiologia
[Mh] Termos MeSH secundário: Técnicas de Tipagem Bacteriana
Bacteroidetes/genética
Bacteroidetes/isolamento & purificação
Composição de Bases
China
DNA Bacteriano/genética
Endófitos/classificação
Endófitos/genética
Endófitos/isolamento & purificação
Ácidos Graxos/química
Fosfolipídeos/química
RNA Ribossômico 16S/genética
Análise de Sequência de DNA
Vitamina K 2/análogos & derivados
Vitamina K 2/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Bacterial); 0 (Fatty Acids); 0 (Phospholipids); 0 (RNA, Ribosomal, 16S); 11032-49-8 (Vitamin K 2); 8427BML8NY (vitamin MK 7)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170908
[Lr] Data última revisão:
170908
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170713
[St] Status:MEDLINE
[do] DOI:10.1099/ijsem.0.001911


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[PMID]:28603134
[Au] Autor:Hussain L; Abbas K; Ahmad B; Baber M; Muhammad SA; Qadir MI
[Ad] Endereço:Faculty of Pharmaceutical Sciences, Government College University, Faisalabad, Pakistan.
[Ti] Título:Report: Analgesic and anti-inflammatory activity of aqueous-methanolic extract of Aerva javanica.
[So] Source:Pak J Pharm Sci;30(1):213-215, 2017 Jan.
[Is] ISSN:1011-601X
[Cp] País de publicação:Pakistan
[La] Idioma:eng
[Ab] Resumo:The present study was aimed to investigate the analgesic and anti-inflammatory activity of aqueous methanolic extract of Aerva javanica. For measuring analgesic activity, writhing test, hot plate method and formalin test were performed and abdominal writhing was induced by intra-peritoneal injection of 0.2ml of 3% acetic acid. While in formalin test, pain was experimentally induced by injecting 25 µl of 2.5% formalin in left hind paw. In hot plate method, pain was induced thermally by keeping the animals on a hot plate with temperature of about 51°C. Anti-inflammatory activity was assessed by carrageen an induced mice paw edema. The results showed that the extract had significant analgesic activity (p<0.05- p<0.001) and anti-inflammatory activity (p<0.01-p<0.001). Therefore, it was concluded from this study that the extracts of Aerva javanica may be used against pain and inflammation.
[Mh] Termos MeSH primário: Amaranthaceae/química
Analgésicos/farmacologia
Anti-Inflamatórios/farmacologia
Inflamação/prevenção & controle
Metanol/química
Dor/prevenção & controle
Extratos Vegetais/farmacologia
Solventes/química
Água/química
[Mh] Termos MeSH secundário: Ácido Acético
Analgésicos/isolamento & purificação
Animais
Anti-Inflamatórios/isolamento & purificação
Chondrus
Modelos Animais de Doenças
Flores/química
Formaldeído
Inflamação/induzido quimicamente
Camundongos
Dor/induzido quimicamente
Dor/fisiopatologia
Limiar da Dor/efeitos dos fármacos
Fitoterapia
Extratos Vegetais/isolamento & purificação
Folhas de Planta/química
Plantas Medicinais
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Analgesics); 0 (Anti-Inflammatory Agents); 0 (Plant Extracts); 0 (Solvents); 059QF0KO0R (Water); 1HG84L3525 (Formaldehyde); Q40Q9N063P (Acetic Acid); Y4S76JWI15 (Methanol)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171103
[Lr] Data última revisão:
171103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170613
[St] Status:MEDLINE


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[PMID]:28603115
[Au] Autor:Shad AA; Asmat S; Bakht J; Ala Uddin A
[Ad] Endereço:Department of Agricultural Chemistry, The University of Agriculture Peshawar, KPK, Pakistan.
[Ti] Título:Screening of Aerva javanica and Linum ustitatissimum for their anti-diabetic and anti-oxidant activity.
[So] Source:Pak J Pharm Sci;30(1):67-73, 2017 Jan.
[Is] ISSN:1011-601X
[Cp] País de publicação:Pakistan
[La] Idioma:eng
[Ab] Resumo:The present study investigates anti-diabetic and anti-oxidant potentials of the aerial parts of Aerva javanica and seeds of Linum ustitatissimum. Our results revealed that maximum antioxidant activity was found in hexane fractions of both plants. Linum ustitatissimum recorded maximum antioxidant value of 15.77mmol/L while Aerva javanica had antioxidant activity of 16.07mmol/L. Anti-diabetic activities were also evaluated using normal rats, induced diabetic (untreated) rats and treated diabetic rats. Aerva javanica revealed a significant potential in decreasing blood glucose level to 77.08mg/dl and body weight 76.30mg/kg while Linum ustitatissimum reduced blood glucose level to 84.20mg/dl and body weight 83.090mg/kg. From these results it can be concluded that both plants possesses anti-diabetic and anti-oxidant activity.
[Mh] Termos MeSH primário: Amaranthaceae/química
Antioxidantes/farmacologia
Glicemia/efeitos dos fármacos
Diabetes Mellitus Experimental/tratamento farmacológico
Linho/química
Hipoglicemiantes/farmacologia
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Aloxano
Animais
Antioxidantes/química
Antioxidantes/isolamento & purificação
Benzotiazóis/química
Biomarcadores/sangue
Compostos de Bifenilo/química
Glicemia/metabolismo
Cloretos/química
Diabetes Mellitus Experimental/sangue
Diabetes Mellitus Experimental/induzido quimicamente
Compostos Férricos/química
Hexanos/química
Hipoglicemiantes/química
Hipoglicemiantes/isolamento & purificação
Oxirredução
Fitoterapia
Picratos/química
Componentes Aéreos da Planta/química
Extratos Vegetais/química
Extratos Vegetais/isolamento & purificação
Plantas Medicinais
Ratos
Solventes/química
Ácidos Sulfônicos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Benzothiazoles); 0 (Biomarkers); 0 (Biphenyl Compounds); 0 (Blood Glucose); 0 (Chlorides); 0 (Ferric Compounds); 0 (Hexanes); 0 (Hypoglycemic Agents); 0 (Picrates); 0 (Plant Extracts); 0 (Solvents); 0 (Sulfonic Acids); 28752-68-3 (2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid); 6SW5YHA5NG (Alloxan); DFD3H4VGDH (1,1-diphenyl-2-picrylhydrazyl); U38V3ZVV3V (ferric chloride)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171103
[Lr] Data última revisão:
171103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170613
[St] Status:MEDLINE


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[PMID]:28502749
[Au] Autor:Mas S; Oeo-Santos C; Cuesta-Herranz J; Díaz-Perales A; Colás C; Fernández J; Barber D; Rodríguez R; de Los Ríos V; Barderas R; Villalba M
[Ad] Endereço:Dpto. Bioquímica y Biología Molecular I, Universidad Complutense de Madrid, Madrid, Spain.
[Ti] Título:A relevant IgE-reactive 28kDa protein identified from Salsola kali pollen extract by proteomics is a natural degradation product of an integral 47kDa polygalaturonase.
[So] Source:Biochim Biophys Acta;1865(8):1067-1076, 2017 08.
[Is] ISSN:0006-3002
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:A highly prevalent IgE-binding protein band of 28kDa is observed when Salsola kali pollen extract is incubated with individual sera from Amaranthaceae pollen sensitized patients. By an immunoproteomic analysis of S. kali pollen extract, we identified this protein band as an allergenic polygalacturonase enzyme. The allergen, named Sal k 6, exhibits a pI of 7.14 and a molecular mass of 39,554.2Da. It presents similarities to Platanaceae, Poaceae, and Cupressaceae allergenic polygalacturonases. cDNA-encoding sequence was subcloned into the pET41b vector and produced in bacteria as a His-tag fusion recombinant protein. The far-UV CD spectrum determined that rSal k 6 was folded. Immunostaining of the S. kali pollen protein extract with a rSal k 6-specific pAb and LC-MS/MS proteomic analyses confirmed the co-existence of the 28kDa band together with an allergenic band of about 47kDa in the pollen extract. Therefore, the 28kDa was assigned as a natural degradation product of the 47kDa integral polygalacturonase. The IgE-binding inhibition to S. kali pollen extract using rSal k 6 as inhibitor showed that signals directed to both protein bands of 28 and 47kDa were completely abrogated. The average prevalence of rSal k 6 among the three populations analyzed was 30%, with values correlating well with the levels of grains/m of Amaranthaceae pollen. Sal k 6 shares IgE epitopes with Oleaceae members (Fraxinus excelsior, Olea europaea and Syringa vulgaris), with IgE-inhibition values ranging from 20% to 60%, respectively. No IgE-inhibition was observed with plant-derived food extracts.
[Mh] Termos MeSH primário: Antígenos de Plantas/metabolismo
Glicosídeos/metabolismo
Imunoglobulina E/metabolismo
Proteínas de Plantas/metabolismo
Pólen/metabolismo
Salsola/metabolismo
[Mh] Termos MeSH secundário: Amaranthaceae/química
Amaranthaceae/metabolismo
Sequência de Aminoácidos
Antígenos de Plantas/química
Sequência de Bases
Clonagem Molecular/métodos
Reações Cruzadas/fisiologia
Glicosídeos/química
Oleaceae/química
Oleaceae/metabolismo
Proteínas de Plantas/química
Pólen/química
Ligação Proteica/fisiologia
Proteômica/métodos
Proteínas Recombinantes de Fusão/química
Proteínas Recombinantes de Fusão/metabolismo
Salsola/química
Alinhamento de Sequência
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antigens, Plant); 0 (Glycosides); 0 (Plant Proteins); 0 (Recombinant Fusion Proteins); 37341-29-0 (Immunoglobulin E)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170926
[Lr] Data última revisão:
170926
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170516
[St] Status:MEDLINE



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