Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.198.500.100.333 [Categoria DeCS]
Referências encontradas : 50 [refinar]
Mostrando: 1 .. 10   no formato [Detalhado]

página 1 de 5 ir para página              

  1 / 50 MEDLINE  
              next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:29248772
[Au] Autor:Spórna-Kucab A; Milo A; Kumorkiewicz A; Wybraniec S
[Ad] Endereço:Department of Analytical Chemistry, Institute C-1, Faculty of Chemical Engineering and Technology, Cracow University of Technology, ul. Warszawska 24, Cracow 31-155, Poland. Electronic address: anetasporna@chemia.pk.edu.pl.
[Ti] Título:Studies on polar high-speed counter-current chromatographic systems in separation of amaranthine-type betacyanins from Celosia species.
[So] Source:J Chromatogr B Analyt Technol Biomed Life Sci;1073:96-103, 2018 Jan 15.
[Is] ISSN:1873-376X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Betacyanins, natural plant pigments exhibiting antioxidant and chemopreventive properties, were extracted from Celosia spicata (Thouars) Spreng. inflorescences and separated by high-speed counter-current chromatography (HSCCC) in two polar solvent systems composed of: TBME - 1-BuOH - ACN - H O (0.7% HFBA, 2:2:1:5, v/v/v/v) (system I) and EtOH - ACN - 1-PrOH - (NH ) SO - H O (0.5:0.5:0.5:1.2:1, v/v/v/v/v) (system II). The systems were used in the head-to-tail (system I) and tail-to-head (system II) mode. The flow rate of the mobile phase was 2.0 ml/min and the column rotation speed was 860 rpm. The retention of the stationary phase was 73.5% (system I) and 80.0% (system II). For the identification of separated betacyanins in the crude extract as well as in the HSCCC fractions, LC-DAD-ESI-MS/MS analyses were performed. Depending on the target compounds, each of the systems exhibit meaningfully different selectivity and applicability. For the pairs of amaranthines (1/1') and betanins (2/2'), the best choice is the system II, but the acylated amaranthine pairs (3/3' and 4/4') can be resolved only in the ion-pair system I. For the indication of the most suitable solvent system for Celosia plumosa hort., Celosia cristata L. and Celosia spicata (Thouars) Spreng. species, the profiles of betacyanins in different plant parts were studied.
[Mh] Termos MeSH primário: Betacianinas/isolamento & purificação
Celosia/química
Distribuição Contracorrente/métodos
Extratos Vegetais/química
[Mh] Termos MeSH secundário: Betacianinas/análise
Betacianinas/química
Cromatografia Líquida
Espectrometria de Massas em Tandem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Betacyanins); 0 (Plant Extracts); 15167-84-7 (amaranthin betacyanin)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180302
[Lr] Data última revisão:
180302
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171218
[St] Status:MEDLINE


  2 / 50 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28659043
[Au] Autor:Liu X; Zhang J; Guo K; Jia A; Zhang M; Shi Y; Liu C; Xiao L; Sun Z
[Ad] Endereço:a Key Laboratory for Biosensors of Shandong Province , Biology Institute of Shandong Academy of Sciences , Jinan , China.
[Ti] Título:Three new oleanane-type triterpenoid saponins from the seeds of Celosia cristata L.
[So] Source:Nat Prod Res;32(2):167-174, 2018 Jan.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Phytochemical investigation of the 1-butanol soluble fraction of 60% ethanol extract of the seeds of Celosia cristata L. led to the identification of three new oleanane-type triterpenoid saponins. Using D and D NMR experiment methods, ESI-MS analysis and acid hydrolysis, their structures were identified as 3-O-[ß-D-xylopyranosyl-(1 â†’ 3)-ß-D-glucuronopyranosyl]-2ß-hydroxy-oleanolic acid-28-O-ß-D-glucopyranoside (1), 3-O-[ß-D-xylopyranosyl-(1 â†’ 3)-ß-D-glucuronopyranosyl]-2ß, 23-dihydroxy-oleanolic acid-28-O-ß-D-glucopyranoside (2) and 3-O-[ß-D-glucopyranosyl-(1 â†’ 4)-ß-D-glucopyranosyl]-2-hydroxyl-medicagenic acid-28-O-ß-D-glucopyranosyide (3), respectively.
[Mh] Termos MeSH primário: Celosia/química
Ácido Oleanólico/análogos & derivados
Ácido Oleanólico/isolamento & purificação
Saponinas/isolamento & purificação
[Mh] Termos MeSH secundário: Configuração de Carboidratos
Sequência de Carboidratos
Hidrólise
Espectroscopia de Ressonância Magnética
Estrutura Molecular
Ácido Oleanólico/química
Saponinas/química
Sementes/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Saponins); 0 (oleanane); 6SMK8R7TGJ (Oleanolic Acid)
[Em] Mês de entrada:1802
[Cu] Atualização por classe:180228
[Lr] Data última revisão:
180228
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170630
[St] Status:MEDLINE
[do] DOI:10.1080/14786419.2017.1343317


  3 / 50 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28405784
[Au] Autor:Bhide AJ; Channale SM; Yadav Y; Bhattacharjee K; Pawar PK; Maheshwari VL; Gupta VS; Ramasamy S; Giri AP
[Ad] Endereço:Plant Molecular Biology Unit, Division of Biochemical Sciences, CSIR-National Chemical Laboratory, Dr. Homi Bhabha Road, Pune, 411 008, India.
[Ti] Título:Genomic and functional characterization of coleopteran insect-specific α-amylase inhibitor gene from Amaranthus species.
[So] Source:Plant Mol Biol;94(3):319-332, 2017 Jun.
[Is] ISSN:1573-5028
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The smallest 32 amino acid α-amylase inhibitor from Amaranthus hypochondriacus (AAI) is reported. The complete gene of pre-protein (AhAI) encoding a 26 amino acid (aa) signal peptide followed by the 43 aa region and the previously identified 32 aa peptide was cloned successfully. Three cysteine residues and one disulfide bond conserved within known α-amylase inhibitors were present in AhAI. Identical genomic and open reading frame was found to be present in close relatives of A. hypochondriacus namely Amaranthus paniculatus, Achyranthes aspera and Celosia argentea. Interestingly, the 3'UTR of AhAI varied in these species. The highest expression of AhAI was observed in A. hypochondriacus inflorescence; however, it was not detected in the seed. We hypothesized that the inhibitor expressed in leaves and inflorescence might be transported to the seeds. Sub-cellular localization studies clearly indicated the involvement of AhAI signal peptide in extracellular secretion. Full length rAhAI showed differential inhibition against α-amylases from human, insects, fungi and bacteria. Particularly, α-amylases from Helicoverpa armigera (Lepidoptera) were not inhibited by AhAI while Tribolium castaneum and Callosobruchus chinensis (Coleoptera) α-amylases were completely inhibited. Molecular docking of AhAI revealed tighter interactions with active site residues of T. castaneum α-amylase compared to C. chinensis α-amylase, which could be the rationale behind the disparity in their IC . Normal growth, development and adult emergence of C. chinensis were hampered after feeding on rAhAI. Altogether, the ability of AhAI to affect the growth of C. chinensis demonstrated its potential as an efficient bio-control agent, especially against stored grain pests.
[Mh] Termos MeSH primário: Amaranthus/metabolismo
Coleópteros/enzimologia
Inibidores Enzimáticos/metabolismo
Inibidores Enzimáticos/farmacologia
Regulação da Expressão Gênica de Plantas/fisiologia
Proteínas de Plantas/metabolismo
alfa-Amilases/antagonistas & inibidores
[Mh] Termos MeSH secundário: Achyranthes/metabolismo
Sequência de Aminoácidos
Animais
Celosia/metabolismo
Clonagem Molecular
Modelos Moleculares
Proteínas de Plantas/genética
Conformação Proteica
Transporte Proteico
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Enzyme Inhibitors); 0 (Plant Proteins); EC 3.2.1.1 (alpha-Amylases)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170414
[St] Status:MEDLINE
[do] DOI:10.1007/s11103-017-0609-5


  4 / 50 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:28190196
[Au] Autor:Park YJ; Moon C; Kang JH; Choi TJ
[Ad] Endereço:Department of Microbiology, Pukyong National University, 45, Yongso-ro, Nam-Gu, Busan, 48513, Republic of Korea.
[Ti] Título:Antiviral effects of extracts from Celosia cristata and Raphanus sativus roots against viral hemorrhagic septicemia virus.
[So] Source:Arch Virol;162(6):1711-1716, 2017 Jun.
[Is] ISSN:1432-8798
[Cp] País de publicação:Austria
[La] Idioma:eng
[Ab] Resumo:The antiviral activity of an extract mixture from Celosia cristata and Raphanus sativus was tested against viral hemorrhagic septicemia virus (VHSV). Pretreatment of EPC cells with this extract up to 72 h before VHSV infection markedly reduced the virus titer, but it had no effect when added after virus inoculation. In olive flounder that received 5 µg of extract per fish, Mx expression peaked at 48 h after treatment. In contrast, ISG15 and TLR2 expression peaked at 72 h, and that of TLR7 peaked at 48 h, followed by a slight decrease at 72 h, indicating that the antiviral activity was mediated by induction of gene expression involved in the innate immune response.
[Mh] Termos MeSH primário: Antivirais/farmacologia
Celosia/química
Doenças dos Peixes/virologia
Septicemia Hemorrágica Viral/virologia
Novirhabdovirus/efeitos dos fármacos
Extratos Vegetais/farmacologia
Raphanus/química
[Mh] Termos MeSH secundário: Animais
Antivirais/isolamento & purificação
Doenças dos Peixes/genética
Doenças dos Peixes/metabolismo
Proteínas de Peixes/genética
Proteínas de Peixes/metabolismo
Linguado/virologia
Septicemia Hemorrágica Viral/genética
Septicemia Hemorrágica Viral/metabolismo
Novirhabdovirus/fisiologia
Extratos Vegetais/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antiviral Agents); 0 (Fish Proteins); 0 (Plant Extracts)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170630
[Lr] Data última revisão:
170630
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170213
[St] Status:MEDLINE
[do] DOI:10.1007/s00705-017-3270-z


  5 / 50 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:27721071
[Au] Autor:Jiang Y; Liu FJ; Wang YM; Li HJ
[Ad] Endereço:Nanjing Forestry University, Nanjing 210037, China. Electronic address: jiangyancpu@126.com.
[Ti] Título:Dereplication-guided isolation of novel hepatoprotective triterpenoid saponins from Celosiae Semen by high-performance liquid chromatography coupled with electrospray ionization tandem quadrupole-time-of-flight mass spectrometry.
[So] Source:J Pharm Biomed Anal;132:148-155, 2017 Jan 05.
[Is] ISSN:1873-264X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Although natural products (NPs) from ethnomedical plants have played a vital role in modern drug discovery, separation and purification of bioactive compounds from plant extract is still challenging. In this study, a dereplication strategy using HPLC-QTOF-MS was employed to rapidly discover and highly targeted isolate the novel hepatoprotective triterpenoid saponins from the methanol extract of Celosiae Semen. Firstly, four known saponins, i.e. celosin H, celosin I, celosin J, and pseudoginsenoside RT1 were selected as model compounds, and their fragmentation patterns in ESI-QTOF-MS/MS were characterized. Secondly, an HPLC-QTOF-MS/MS method was applied to chemically screen the saponins of interest, and thereby to guide the subsequent fraction and isolation procedure. Thirdly, the targeted isolation of desired compounds afforded two new triterpenoid saponins namely celosin K (1) and celosin L (2), which were structurally elucidated by combination of extensive NMR spectroscopic and chemical analyses. Finally, the protective effects of compounds 1 and 2 against APAP-induced hepatotoxicity in HepG2 cells were evaluated. These results indicate that the HPLC-QTOF-MS-guided isolation is an efficient methodology for isolating new NPs from medicinal plants through improving selectivity in separation and purification process.
[Mh] Termos MeSH primário: Celosia/química
Doença Hepática Induzida por Substâncias e Drogas/prevenção & controle
Extratos Vegetais/química
Saponinas/química
[Mh] Termos MeSH secundário: Cromatografia Líquida de Alta Pressão
Células Hep G2
Seres Humanos
Fígado/efeitos dos fármacos
Fígado/lesões
Espectroscopia de Ressonância Magnética
Monossacarídeos/química
Plantas Medicinais/química
Reprodutibilidade dos Testes
Sementes/química
Espectrometria de Massas por Ionização por Electrospray
Espectrometria de Massas em Tandem
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Monosaccharides); 0 (Plant Extracts); 0 (Saponins)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170912
[Lr] Data última revisão:
170912
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161011
[St] Status:MEDLINE


  6 / 50 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:26344289
[Au] Autor:Sun Z; Peng Y; Zhao WW; Xiao LL; Yang PM
[Ad] Endereço:State Key Laboratory of New Drug and Pharmaceutical Process, Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, Shanghai 200040, China; Fengxian Hospital affiliated to Southern Medical University, Shanghai 201499, China.
[Ti] Título:Purification, characterization and immunomodulatory activity of a polysaccharide from Celosia cristata.
[So] Source:Carbohydr Polym;133:337-44, 2015 Nov 20.
[Is] ISSN:1879-1344
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A polysaccharide CP1-1 was isolated and purified from Celosia cristata. Its average molecular weight was 2.3kDa and it was composed of glucose and galactose in a ratio of 1.00:2.03, and traces of mannose. Chemical characterization of CP1-1 was elucidated by methylation analysis. CP1-1 was a branched glucogalactan which was mainly composed of 1,6-linked Galp and 1,6-linked Glcp with a ratio of 5.6:3.8. The branches were at the O-3 of the main chain and might be composed of single terminal (1→)-linked glucopyranose and galactopyranose. CP1-1 also significantly promoted the proliferation and neutral red phagocytosis of RAW 264.7 macrophage cells in vitro. In addition, CP1-1 promoted cell proliferation by enhancing the production of nitric oxide (NO), tumor necrosis factor-α (TNF-α), interleukin (IL)-6 and IL-1ß. These results suggested that the polysaccharide from C. cristata could be used as a potential immunostimulator.
[Mh] Termos MeSH primário: Celosia/química
Fatores Imunológicos/química
Fatores Imunológicos/farmacologia
Polissacarídeos/química
Polissacarídeos/farmacologia
[Mh] Termos MeSH secundário: Animais
Proliferação Celular/efeitos dos fármacos
Citocinas/biossíntese
Fatores Imunológicos/isolamento & purificação
Macrófagos/citologia
Macrófagos/efeitos dos fármacos
Macrófagos/imunologia
Macrófagos/metabolismo
Metilação
Camundongos
Monossacarídeos/análise
Óxido Nítrico/biossíntese
Fagocitose/efeitos dos fármacos
Polissacarídeos/isolamento & purificação
Células RAW 264.7
Sementes/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Cytokines); 0 (Immunologic Factors); 0 (Monosaccharides); 0 (Polysaccharides); 31C4KY9ESH (Nitric Oxide)
[Em] Mês de entrada:1606
[Cu] Atualização por classe:150908
[Lr] Data última revisão:
150908
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150908
[St] Status:MEDLINE


  7 / 50 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
PubMed Central Texto completo
Texto completo
[PMID]:26288477
[Au] Autor:Telagari M; Hullatti K
[Ad] Endereço:Department of Pharmacognosy, KLES College of Pharmacy, Belagavi, Karnataka, India.
[Ti] Título:In-vitro α-amylase and α-glucosidase inhibitory activity of Adiantum caudatum Linn. and Celosia argentea Linn. extracts and fractions.
[So] Source:Indian J Pharmacol;47(4):425-9, 2015 Jul-Aug.
[Is] ISSN:1998-3751
[Cp] País de publicação:India
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: The objective of the present study was to provide an in-vitro evidence for the potential inhibitory activity of extracts and fractions of Adiantum caudatum Linn. and Celosia argentea Linn. on α-amylase and α-glucosidase enzymes. MATERIALS AND METHODS: The plant extracts were prepared, first with cold maceration (70% v/v ethanol) and then by Soxhlation techniques (95% v/v ethanol). Subsequently, the combined extracts were subjected for fractionation. Different concentrations (0.1, 0.2, 0.3, 0.4, and 0.5 mg/ml) of extract and fractions were subjected to α-amylase and α-glucosidase inhibitory assay. The absorbance was measured at 540 and 405 nm using multiplate reader and the percentage of α- amylase and α- glucosidase inhibitory activity and IC50 values of extract and fractions were calculated. RESULTS: Fraction 2 of A. caudatum and fraction 4 of C. argentea has shown highest α-amylase and α-glucosidase inhibitory potential with IC50 values of 0.241, 0.211 and 0.294, 0.249 mg/ml, respectively, which was comparable with acarbose (0.125 and 0.93 mg/ml). Whereas, extracts and remaining fractions of both the plants have shown lesser activity. CONCLUSION: The results of the present study indicate that, fraction 2 of A. caudatum, rich in triterpenoids and phenolics and fraction 4 of C. argentea, rich in flavonoids, are effective α- amylase and α- glucosidase inhibitors, which may be helpful to reduce the postprandial glucose levels. Hence, further studies may throw light on the antidiabetic potential of A. caudatum and C. argentea, especially in the management of type 2 diabetes.
[Mh] Termos MeSH primário: Adiantum/química
Celosia/química
Inibidores Enzimáticos/farmacologia
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Relação Dose-Resposta a Droga
Inibidores Enzimáticos/administração & dosagem
Inibidores Enzimáticos/isolamento & purificação
Técnicas In Vitro
Concentração Inibidora 50
Extratos Vegetais/administração & dosagem
alfa-Amilases/antagonistas & inibidores
alfa-Glucosidases/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Enzyme Inhibitors); 0 (Plant Extracts); EC 3.2.1.1 (alpha-Amylases); EC 3.2.1.20 (alpha-Glucosidases)
[Em] Mês de entrada:1605
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150820
[St] Status:MEDLINE
[do] DOI:10.4103/0253-7613.161270


  8 / 50 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:25727687
[Au] Autor:Guadarrama-Flores B; Rodríguez-Monroy M; Cruz-Sosa F; García-Carmona F; Gandía-Herrero F
[Ad] Endereço:†Departamento de Biotecnología, Universidad Autónoma Metropolitana-Unidad Iztapalapa, Col. Vicentina, 09340 Ciudad de México, Federal District, Mexico.
[Ti] Título:Production of dihydroxylated betalains and dopamine in cell suspension cultures of Celosia argentea var. plumosa.
[So] Source:J Agric Food Chem;63(10):2741-9, 2015 Mar 18.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Betalains are plant pigments of hydrophilic nature with demonstrated chemopreventive potential in cancer cell lines and animal models. Among the betalains, those containing an aromatic moiety with two free hydroxyl groups possess the strongest antioxidant and free radical scavenging activities. The betaxanthins dopaxanthin and miraxanthin V and the betacyanins betanidin and decarboxy-betanidin are the only natural betalains with catecholic substructures. These four pigments have been produced in cell cultures established from hypocotyls of the plant Celosia argentea. Two stable and differentially colored cell lines, yellow and red, were maintained on Murashige and Skoog medium supplemented with the plant growth regulators 6-benzylaminopurine (6.66 µM) and 2,4-dichlorophenoxyacetic acid (6.79 µM). Derived suspension cultures showed increased production of dihydroxylated betalains in the cells and secreted to the medium with a maximum reached after 8 days of culture. In addition, precursor molecules betalamic acid and dopamine, with content up to 42.08 mg/g dry weight, were also obtained. The joint presence of the bioactive betalains together with the production of dopamine and betalamic acid show the ability of cell cultures of C. argentea to become a stable source of valuable phytochemicals.
[Mh] Termos MeSH primário: Betalaínas/análise
Celosia/química
Dopamina/análise
[Mh] Termos MeSH secundário: Betalaínas/metabolismo
Células Cultivadas
Celosia/crescimento & desenvolvimento
Celosia/metabolismo
Dopamina/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
37279-84-8 (Betalains); VTD58H1Z2X (Dopamine)
[Em] Mês de entrada:1510
[Cu] Atualização por classe:150318
[Lr] Data última revisão:
150318
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150303
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.5b00065


  9 / 50 MEDLINE  
              first record previous record next record last record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:25172750
[Au] Autor:Kim YS; Hwang JW; Sung SH; Jeon YJ; Jeong JH; Jeon BT; Moon SH; Park PJ
[Ad] Endereço:Department of Biotechnology, Konkuk University, Chungju, Chungbuk 380-701, Republic of Korea; Department of Applied Life Science, Konkuk University, Chungju, Chungbuk 380-701, Republic of Korea.
[Ti] Título:Antioxidant activity and protective effect of extract of Celosia cristata L. flower on tert-butyl hydroperoxide-induced oxidative hepatotoxicity.
[So] Source:Food Chem;168:572-9, 2015 Feb 01.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:This study was undertaken to evaluate the antioxidant potential and protective effects of Celosia cristata L. (Family: Amaranthaceae) flower (CCF) extracts on tert-butyl-hydroperoxide (t-BHP)-induced oxidative damage in the hepatocytes of Chang cells and rat livers. In vitro, CCF extracts exhibited protective effect through their radical scavenging ability to enhance cell viability, prevent reactive oxygen species (ROS) generation, and inhibit mitochondrial membrane depolarisation in t-BHP-induced hepatotoxicity in Chang cells. In vivo, oral feeding of CCF (100mg and 500mg/kg of body weight) to rats for five consecutive days before a single dose of t-BHP (2mmol/kg, i.p.) showed a significant (p<0.05) protective effect by lowering serum levels of glutamate oxaloacetate transaminase (GOT) and glutamate pyruvate transaminase (GPT). The extract decreased the hepatic levels of lipid peroxidation (MDA) and serum level of triglyceride (TG) against t-BHP-induced oxidative stress. These results indicate that CCF extract prevented oxidative stress-induced liver injury by enhancing hepatocyte antioxidant abilities.
[Mh] Termos MeSH primário: Celosia/química
Doença Hepática Induzida por Substâncias e Drogas/patologia
Hepatócitos/efeitos dos fármacos
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Animais
Antioxidantes/química
Antioxidantes/farmacologia
Linhagem Celular
Sobrevivência Celular/efeitos dos fármacos
Celosia/metabolismo
Doença Hepática Induzida por Substâncias e Drogas/metabolismo
Doença Hepática Induzida por Substâncias e Drogas/prevenção & controle
Flores/química
Flores/metabolismo
Hepatócitos/citologia
Peroxidação de Lipídeos/efeitos dos fármacos
Masculino
Potencial da Membrana Mitocondrial/efeitos dos fármacos
Estresse Oxidativo/efeitos dos fármacos
Extratos Vegetais/química
Substâncias Protetoras/química
Substâncias Protetoras/farmacologia
Ratos
Ratos Sprague-Dawley
Espécies Reativas de Oxigênio/metabolismo
terc-Butil Hidroperóxido/toxicidade
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antioxidants); 0 (Plant Extracts); 0 (Protective Agents); 0 (Reactive Oxygen Species); 955VYL842B (tert-Butylhydroperoxide)
[Em] Mês de entrada:1505
[Cu] Atualização por classe:161125
[Lr] Data última revisão:
161125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140831
[St] Status:MEDLINE


  10 / 50 MEDLINE  
              first record previous record
seleciona
para imprimir
Fotocópia
Texto completo
[PMID]:24456247
[Au] Autor:Pang X; Yan HX; Wang ZF; Fan MX; Zhao Y; Fu XT; Xiong CQ; Zhang J; Ma BP; Guo HZ
[Ad] Endereço:a Beijing Institute of Radiation Medicine , Beijing , 100850 , China.
[Ti] Título:New oleanane-type triterpenoid saponins isolated from the seeds of Celosia argentea.
[So] Source:J Asian Nat Prod Res;16(3):240-7, 2014.
[Is] ISSN:1477-2213
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Three new oleanane-type triterpenoid saponins named celosins H, I, and J were isolated from the seeds of Celosia argentea L. Their structures were characterized as 3-O-ß-D-xylopyranosyl-(1 → 3)-ß-D-glucuronopyranosyl-polygalagenin 28-O-ß-D-glucopyranosyl ester, 3-O-ß-D-glucuronopyranosyl-medicagenic acid 28-O-ß-D-xylcopyranosyl-(1 → 4)-α-L-rhamnopyranosyl-(1 → 2)-ß-D-fucopyranosyl ester, and 3-O-ß-D-glucuronopyranosyl-medicagenic acid 28-O-α-L-arabinopyranosyl-(1 → 3)-[ß-D-xylcopyranosyl-(1 → 4)]-α-L-rhamnopyranosyl-(1 → 2)-ß-D-fucopyranosyl ester by NMR, MS, and chemical evidences, respectively. In our opinion, celosins H-J could be used as chemical markers for the quality control of C. argentea seeds.
[Mh] Termos MeSH primário: Celosia/química
Medicamentos de Ervas Chinesas/isolamento & purificação
Ácido Oleanólico/análogos & derivados
Saponinas/isolamento & purificação
[Mh] Termos MeSH secundário: Medicamentos de Ervas Chinesas/química
Estrutura Molecular
Ressonância Magnética Nuclear Biomolecular
Ácido Oleanólico/química
Ácido Oleanólico/isolamento & purificação
Saponinas/química
Sementes/química
Estereoisomerismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Drugs, Chinese Herbal); 0 (Saponins); 0 (celosin H); 0 (celosin I); 0 (celosin J); 0 (oleanane); 6SMK8R7TGJ (Oleanolic Acid)
[Em] Mês de entrada:1403
[Cu] Atualização por classe:140124
[Lr] Data última revisão:
140124
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140125
[St] Status:MEDLINE
[do] DOI:10.1080/10286020.2013.879120



página 1 de 5 ir para página              
   


Refinar a pesquisa
  Base de dados : MEDLINE Formulário avançado   

    Pesquisar no campo  
1  
2
3
 
           



Search engine: iAH v2.6 powered by WWWISIS

BIREME/OPAS/OMS - Centro Latino-Americano e do Caribe de Informação em Ciências da Saúde