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Pesquisa : B01.650.940.800.575.912.250.198.500.100.666 [Categoria DeCS]
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[PMID]:28771638
[Au] Autor:Chou WC; Lin SS; Yeh SD; Li SL; Peng YC; Fan YH; Chen TC
[Ad] Endereço:Department of Biotechnology, Asia University, Wufeng, Taichung, Taiwan.
[Ti] Título:Characterization of the genome of a phylogenetically distinct tospovirus and its interactions with the local lesion-induced host Chenopodium quinoa by whole-transcriptome analyses.
[So] Source:PLoS One;12(8):e0182425, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Chenopodium quinoa is a natural local lesion host of numerous plant viruses, including tospoviruses (family Bunyaviridae). Groundnut chlorotic fan-spot tospovirus (GCFSV) has been shown to consistently induce local lesions on the leaves of C. quinoa 4 days post-inoculation (dpi). To reveal the whole genome of GCFSV and its interactions with C. quinoa, RNA-seq was performed to determine the transcriptome profiles of C. quinoa leaves. The high-throughput reads from infected C. quinoa leaves were used to identify the whole genome sequence of GCFSV and its single nucleotide polymorphisms. Our results indicated that GCFSV is a phylogenetically distinct tospovirus. Moreover, 27,170 coding and 29,563 non-coding sequences of C. quinoa were identified through de novo assembly, mixing reads from mock and infected samples. Several key genes involved in the modulation of hypersensitive response (HR) were identified. The expression levels of 4,893 deduced complete genes annotated using the Arabidopsis genome indicated that several HR-related orthologues of pathogenesis-related proteins, transcription factors, mitogen-activated protein kinases, and defense proteins were significantly expressed in leaves that formed local lesions. Here, we also provide new insights into the replication progression of a tospovirus and the molecular regulation of the C. quinoa response to virus infection.
[Mh] Termos MeSH primário: Chenopodium/genética
Chenopodium/virologia
Regulação da Expressão Gênica de Plantas
Genes de Plantas
Interações Hospedeiro-Patógeno
Tospovirus/fisiologia
Transcriptoma
[Mh] Termos MeSH secundário: Genoma Viral
Sequenciamento de Nucleotídeos em Larga Escala
Filogenia
Doenças das Plantas
Folhas de Planta
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171006
[Lr] Data última revisão:
171006
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170804
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0182425


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[PMID]:28653919
[Au] Autor:Ullah F; Iqbal N; Ayaz M; Sadiq A; Ullah I; Ahmad S; Imran M
[Ad] Endereço:Department of Pharmacy, University of Malakand, Dir (L), Pakistan.
[Ti] Título:DPPH, ABTS free radical scavenging, antibacterial and phytochemical evaluation of crude methanolic extract and subsequent fractions of Chenopodium botrys aerial parts.
[So] Source:Pak J Pharm Sci;30(3):761-766, 2017 May.
[Is] ISSN:1011-601X
[Cp] País de publicação:Pakistan
[La] Idioma:eng
[Ab] Resumo:We investigated antioxidant, antibacterial potentials and secondary metabolites of Chenopodium botrys aerial parts to rationalize its effectiveness in free radicals induced disorders and infectious diseases. Antioxidant activity of plant extracts were investigated using DPPH and ABTS free radicals scavenging assays. Antibacterial potential was studied using well diffusion method. Phytochemical analysis was performed for the presence of secondary metabolites. In DPPH assay chloroform fraction (CHF), ethyl acetate fraction (EAF) and n-hexane fraction (NHF) were most active causing average inhibition of 65.9, 59.2 and 55.9% at concentration of 1mg/ml with IC values of 140, 30 and 590 µgml respectively. EAF, CHF and aqueous fraction (AQF) revealed highest scavenging effect against ABTS free radicals causing 85.46, 82.73 and 68.80% inhibition with of IC of 75, 94 and 530 µg/ml respectively. In antibacterial assay, CHF was found most effective against S. aureus presenting an inhibitory zone of 19 mm whereas; EAF, CHF and NHF were most active against K. pneumoneae with inhibitory zones of 27.1 mm, 25.4 and 18.7 mm respectively. C. botrys was tested positive for flavonoids, anthraquinones, saponins and tannins. Current findings revealed that that C. botrys is rich source of natural antioxidant and antibacterial bioactive compounds and may be further investigated.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Benzotiazóis/química
Compostos de Bifenilo/química
Chenopodium/química
Depuradores de Radicais Livres/farmacologia
Picratos/química
Componentes Aéreos da Planta/química
Extratos Vegetais/farmacologia
Ácidos Sulfônicos/química
[Mh] Termos MeSH secundário: Metanol/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Benzothiazoles); 0 (Biphenyl Compounds); 0 (Free Radical Scavengers); 0 (Picrates); 0 (Plant Extracts); 0 (Sulfonic Acids); 28752-68-3 (2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid); DFD3H4VGDH (1,1-diphenyl-2-picrylhydrazyl); Y4S76JWI15 (Methanol)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170907
[Lr] Data última revisão:
170907
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170628
[St] Status:MEDLINE


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[PMID]:28229939
[Au] Autor:Kokanova-Nedialkova Z; Nedialkov P; Kondeva-Burdina M; Simeonova R; Tzankova V; Aluani D
[Ad] Endereço:Department of Pharmacognosy, Faculty of Pharmacy, Medical University of Sofia, 2 Dunav Str., 1000 Sofia, Bulgaria. Electronic address: zlatina.kokanova@pharmfac.net.
[Ti] Título:Chenopodium bonus-henricus L. - A source of hepatoprotective flavonoids.
[So] Source:Fitoterapia;118:13-20, 2017 Apr.
[Is] ISSN:1873-6971
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Three new flavonoid glycosides (7-9) named patuletin-3-O-(5″'-О-Е-feruloyl)-ß-d-apiofuranosyl(1→2)[ß-d-glucopyranosyl (1→6)]-ß-d-glucopyranoside (7), spinacetin-3-O-(5″'-О-Е-feruloyl)-ß-d-apiofuranosyl (1→2)[ß-d-glucopyranosyl(1→6)]-ß-d-glucopyranoside (8) and 6-methoxykaempferol-3-O-(5″'-О-Е-feruloyl)-ß-d-apiofuranosyl(1→2)[ß-d-glucopyranosyl (1→6)]-ß-d-glucopyranoside (9) together with six known flavonoid glycosides of patuletin, spinacetin and 6-methoxykaempferol (1-6) were isolated from the aerial parts of C. bonus-henricus and identified with spectroscopic methods (1D and 2D NMR, UV, IR, HRESIMS). The MeOH extract exerts hepatoprotective and antioxidant activities comparable to those of flavonoid complex silymarin in in vitro (60µg/mL) and in vivo (100mg/kg/daily for 7days) models of hepatotoxicity, induced by CCl . Flavonoids (1-9) (100µM), compared to silybin, significantly reduced the cellular damage caused by CCl in rat hepatocytes, preserved cell viability and GSH level, decreased LDH leakage and reduced lipid damage. High concentrations of compounds (1-9) showed marginal or no cytotoxicity on HepG2 cell line. The experiment data suggest that the glycosides of 6-methoxykaempferol, spinacetin and patuletin are a promising and safe class of hepatoprotective agents.
[Mh] Termos MeSH primário: Chenopodium/química
Flavonoides/química
Glicosídeos/química
Hepatócitos/efeitos dos fármacos
Substâncias Protetoras/química
[Mh] Termos MeSH secundário: Animais
Cromonas/química
Cromonas/isolamento & purificação
Flavonoides/isolamento & purificação
Glicosídeos/isolamento & purificação
Células Hep G2
Seres Humanos
Masculino
Estrutura Molecular
Componentes Aéreos da Planta/química
Extratos Vegetais/química
Substâncias Protetoras/isolamento & purificação
Ratos
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Chromones); 0 (Flavonoids); 0 (Glycosides); 0 (Plant Extracts); 0 (Protective Agents); 9BNM33N01N (patuletin)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170224
[St] Status:MEDLINE


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[PMID]:27701037
[Au] Autor:Hsu BY; Lin SW; Inbaraj BS; Chen BH
[Ad] Endereço:Department of Food and Beverage Management, Lee-Ming Institute of Technology, New Taipei City 242, Taiwan.
[Ti] Título:Simultaneous determination of phenolic acids and flavonoids in Chenopodium formosanum Koidz. (djulis) by HPLC-DAD-ESI-MS/MS.
[So] Source:J Pharm Biomed Anal;132:109-116, 2017 Jan 05.
[Is] ISSN:1873-264X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A high performance liquid chromatography-diode array detection-tandem mass spectrometry method (HPLC-DAD-MS/MS) was developed for simultaneous determination of phenolic acids and flavonoids in djulis (Chenopodium formosanum Koidz.), a traditional Chinese herb reported to possess vital biological activities. A high yield of phenolic acids and flavonoids was attained by employing 50% ethanol in water as the extraction solvent and shaking in a 60°C water bath for 3h. A total of 8 phenolic acids and 14 flavonoids were separated and identified within 55min by using a Poroshell 120 EC-C18 column with detection at 280nm, flow rate at 0.8mL/min, column temperature at 35°C, and a gradient solvent system of 0.1% formic acid in water and acetonitrile. Two internal standards caffeic acid and kaempferol-3-O-rutinoside were used for quantitation of phenolic acids and flavonoids in djulis respectively. The amounts of phenolic acids ranged from 11.5±0.8µg/g (caffeoyl-putrescine-derivative (2)) to 1855.3±16.9µg/g (hydroxylphenylacetic acid pentoside), while the flavonoids ranged from 19.93±2.29µg/g (quercetin-3-O-(coumaryl)-rutinoside-pentoside (1)) to 257.3±2.05µg/g (rutin-O-pentoside (2)). A high recovery (89.68-97.20%) and high reproducibility was obtained for both phenolic acids and flavonoids with the relative standard deviation (RSD) for the latter ranging from 0.09-8.22% (intra-day variability) and 0.80-8.48% (inter-day variability). This method may be applied to determination of both phenolic acids and flavonoids in food products and Chinese herbs.
[Mh] Termos MeSH primário: Chenopodium/química
Flavonoides/análise
Hidroxibenzoatos/análise
[Mh] Termos MeSH secundário: Acetonitrilos/química
Ácidos Cafeicos/química
Cromatografia Líquida de Alta Pressão
Flavonoides/química
Hidroxibenzoatos/química
Quempferóis/química
Limite de Detecção
Extratos Vegetais/química
Pós
Reprodutibilidade dos Testes
Solventes/química
Espectrometria de Massas por Ionização por Electrospray
Espectrometria de Massas em Tandem
Temperatura Ambiente
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acetonitriles); 0 (Caffeic Acids); 0 (Flavonoids); 0 (Hydroxybenzoates); 0 (Kaempferols); 0 (Plant Extracts); 0 (Powders); 0 (Solvents); 0 (kaempferol-3-O-rutinoside); 29656-58-4 (phenolic acid); U2S3A33KVM (caffeic acid); Z072SB282N (acetonitrile)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170912
[Lr] Data última revisão:
170912
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161005
[St] Status:MEDLINE


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[PMID]:27847821
[Au] Autor:Hong YH; Huang YL; Liu YC; Tsai PJ
[Ad] Endereço:Department of Nutrition, I-Shou University, Kaohsiung, Taiwan.
[Ti] Título:Djulis ( Koidz.) Water Extract and Its Bioactive Components Ameliorate Dermal Damage in UVB-Irradiated Skin Models.
[So] Source:Biomed Res Int;2016:7368797, 2016.
[Is] ISSN:2314-6141
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Dermal photoaging is a condition of skin suffering inappropriate ultraviolet (UV) exposure and exerts inflammation, tissue alterations, redness, swelling, and uncomfortable feelings. Djulis ( Koidz.) is a cereal food and its antioxidant and pigment constituents may provide skin protection from photoaging, but it still lacks proved experiments. In this study, protective effects of djulis extract (CFE) on UVB-irradiated skin were explored. The results showed that HaCaT cells with 150 g/mL CFE treatment had higher survival and less production of interleukin- (IL-) 6, matrix metalloprotease- (MMP-) 1, and reactive oxygen species (ROS) in UVB-irradiated conditions. Subsequently, in animal studies, mice supplemented with CFE (100 mg/kg BW) were under UVB irradiation and had thinner epidermis and lower IL-6 levels in skin layer. These data demonstrate that bioactive compounds possessing the potency of antiphotoaging exist in CFE. Following that, we found rutin and chlorogenic acid (10-100 M) could significantly increase cell viability and decrease the production of IL-6 in UVB models. Additionally, djulis pigment-betanin has no effect of increasing cell viability in this study. Our findings suggest CFE can protect skin against UV-induced damage and this protection is mainly from contributions of rutin and chlorogenic acid.
[Mh] Termos MeSH primário: Chenopodium/química
Extratos Vegetais/química
Extratos Vegetais/farmacologia
Pele/efeitos dos fármacos
Pele/efeitos da radiação
Raios Ultravioleta/efeitos adversos
Água/química
[Mh] Termos MeSH secundário: Animais
Sobrevivência Celular/efeitos dos fármacos
Ácido Clorogênico/farmacologia
Feminino
Seres Humanos
Interleucina-6/metabolismo
Metaloproteinase 1 da Matriz/metabolismo
Camundongos
Camundongos Endogâmicos BALB C
Pigmentos Biológicos/química
Substâncias Protetoras/farmacologia
Espécies Reativas de Oxigênio/metabolismo
Rutina/farmacologia
Sementes/química
Pele/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Interleukin-6); 0 (Pigments, Biological); 0 (Plant Extracts); 0 (Protective Agents); 0 (Reactive Oxygen Species); 059QF0KO0R (Water); 318ADP12RI (Chlorogenic Acid); 5G06TVY3R7 (Rutin); EC 3.4.24.7 (Matrix Metalloproteinase 1)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161117
[St] Status:MEDLINE


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[PMID]:27287434
[Au] Autor:Ciuffo M; Mammella M; Vallino M; Caciagli P; Turina M
[Ad] Endereço:Istituto per la Protezione Sostenibile delle Piante, Sede di Torino, CNR, Strada delle Cacce 73, 10135, Turin, Italy.
[Ti] Título:Molecular identification and biological characterization of a new potyvirus in lettuce.
[So] Source:Arch Virol;161(9):2549-54, 2016 Sep.
[Is] ISSN:1432-8798
[Cp] País de publicação:Austria
[La] Idioma:eng
[Ab] Resumo:A potyvirus causing necrosis and leaf distortion on lettuce was found in the Lazio region of Italy. Host range analysis showed its ability to infect only Chenopodium quinoa and C. amaranticolor in addition to some lettuce cultivars. The virus could be transmitted by aphids of the species Myzus persicae. The complete 9829-nt genome was characterized. BLAST analysis of sequence of the complete encoded polyprotein showed that the most closely related virus is asparagus virus 1, with 52 % amino acid sequence identity. These results suggest that this virus should be considered a member of a new species in the genus Potyvirus.
[Mh] Termos MeSH primário: Alface/virologia
Doenças das Plantas/virologia
Potyvirus/genética
Potyvirus/isolamento & purificação
[Mh] Termos MeSH secundário: Chenopodium/virologia
Genoma Viral
Filogenia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170131
[Lr] Data última revisão:
170131
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160612
[St] Status:MEDLINE
[do] DOI:10.1007/s00705-016-2920-x


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[PMID]:27166536
[Au] Autor:Uddin G; Rauf A; Siddiqui BS; Khan H; Barkatullah; Ullah R
[Ad] Endereço:Institute of Chemical Sciences, University of Peshawar, Peshawar, KPK, Pakistan.
[Ti] Título:Antinociceptive, antioxidant and phytochemical studies of Pakistani medicinal plants.
[So] Source:Pak J Pharm Sci;29(3):929-33, 2016 May.
[Is] ISSN:1011-601X
[Cp] País de publicação:Pakistan
[La] Idioma:eng
[Ab] Resumo:The aim of the current study was to evaluate the antinociceptive activity of the selected Pakistani medicinal plants (Chenopodium botrys, Micromeria biflora and Teucrium stocksianum) in-vivo followed by their antioxidant potential against 1,1-diphenyl-2-picrylhidrazyl (DPPH) in-vitro. The results demonstrated profound antinociceptive effect of both the crude methanolic extract of Chenopodium botrys (CBM) and subsequent aqueous fraction (CBW) of C. botrys with 80.76% and 84% pain relief in acetic acid induced writhing test at 100 mg/kg i.p respectively. Similarly the crude methanolic extract of Micromeria biflora (MBM) and its subsequent aqueous fraction (MBW) with 66.46% 78.08% pain reversal in acetic acid induced writhing test respectively at 100mg/kg i.p. However, the crude methanolic extract and isolated water fraction of Teucrium stocksianum (TS) did not show any significant effect at test doses. Both the crude extracts and aqueous fractions of selected medicinal plants exhibited marked scavenging effects on DPPH and therefore strongly support the antinociceptive activity. Phytochemical analysis indicated the presence of various classes of natural products (alkaloids, terpenoids, flavonoids etc.) and thus the current finding can be attributed to the presence of these compounds. In short, our findings provide a strong scientific background to the folk uses C. botrys and M. biflora in the management of various painful conditions.
[Mh] Termos MeSH primário: Analgésicos/farmacologia
Antioxidantes/farmacologia
Chenopodium/química
Lamiaceae/química
Dor/prevenção & controle
Compostos Fitoquímicos/farmacologia
Extratos Vegetais/farmacologia
Teucrium/química
[Mh] Termos MeSH secundário: Ácido Acético
Analgésicos/isolamento & purificação
Animais
Antioxidantes/isolamento & purificação
Compostos de Bifenilo/química
Modelos Animais de Doenças
Relação Dose-Resposta a Droga
Metanol/química
Camundongos Endogâmicos BALB C
Dor/induzido quimicamente
Paquistão
Compostos Fitoquímicos/isolamento & purificação
Fitoterapia
Picratos/química
Extratos Vegetais/isolamento & purificação
Plantas Medicinais
Solventes/química
Água/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Analgesics); 0 (Antioxidants); 0 (Biphenyl Compounds); 0 (Phytochemicals); 0 (Picrates); 0 (Plant Extracts); 0 (Solvents); 0 (teucrium extract); 059QF0KO0R (Water); DFD3H4VGDH (1,1-diphenyl-2-picrylhydrazyl); Q40Q9N063P (Acetic Acid); Y4S76JWI15 (Methanol)
[Em] Mês de entrada:1608
[Cu] Atualização por classe:161126
[Lr] Data última revisão:
161126
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160512
[St] Status:MEDLINE


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[PMID]:26810568
[Au] Autor:Podolak I; Olech M; Galanty A; Zaluski D; Grabowska K; Sobolewska D; Michalik M; Nowak R
[Ad] Endereço:a Department of Pharmacognosy , Jagiellonian University Medical College , Cracow , Poland.
[Ti] Título:Flavonoid and phenolic acid profile by LC-MS/MS and biological activity of crude extracts from Chenopodium hybridum aerial parts.
[So] Source:Nat Prod Res;30(15):1766-70, 2016 Aug.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Extracts from leaves and stems of Chenopodium hybridum were characterised for the presence and quantity of flavonoids and phenolic acids by LC-ESI-MS/MS. Five flavonoids and eight phenolic acids were detected for the first time in aerial parts of this plant species, the most abundant compounds being rutin (2.80 µg/g DW), 3-kaempferol rutinoside (2.91 µg/g DW), 4-OH-benzoic (1.86 µg/g DW) and syringic acids (2.31 µg/g DW). Extracts were tested for anti-inflammatory/antiarthritic, antihyaluronidase and cytotoxic activities against human prostate cancer (Du145, PC3) and melanoma cell lines (A375, HTB140 and WM793) of different malignancy. None of the extracts protected bovine serum albumin from heat-induced denaturation. Antihyaluronidase effect at the tested concentration was higher than standard naringenin. Cytotoxic activity was generally low with an exception of the extract from the leaves, which was found most effective against prostate Du145 cell line with 98.28 ± 1.13% of dead cells at 100 µg/mL.
[Mh] Termos MeSH primário: Chenopodium/química
Flavonoides/análise
Hidroxibenzoatos/análise
Componentes Aéreos da Planta/química
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Linhagem Celular Tumoral
Cromatografia Líquida/métodos
Seres Humanos
Espectrometria de Massas em Tandem/métodos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Flavonoids); 0 (Hydroxybenzoates); 0 (Plant Extracts); 29656-58-4 (phenolic acid)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160127
[St] Status:MEDLINE
[do] DOI:10.1080/14786419.2015.1136908


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[PMID]:26646715
[Au] Autor:Lazo-Vélez MA; Guajardo-Flores D; Mata-Ramírez D; Gutiérrez-Uribe JA; Serna-Saldivar SO
[Ad] Endereço:Centro de Biotecnología-FEMSA, Escuela de Biotecnología y Alimentos, Tecnológico de Monterrey-Campus Monterrey, Av. Eugenio Garza Sada 2501 Sur, C.P. 64849, Monterrey, N.L., México.
[Ti] Título:Characterization and Quantitation of Triterpenoid Saponins in Raw and Sprouted Chenopodium berlandieri spp. (Huauzontle) Grains Subjected to Germination with or without Selenium Stress Conditions.
[So] Source:J Food Sci;81(1):C19-26, 2016 Jan.
[Is] ISSN:1750-3841
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Pseudocereal Chenopodium berlandieri spp. (huauzontle) was evaluated to determine saponin composition. Saponins were evaluated in raw and germinated grains subjected to chemical stress induced by sodium selenite. Analysis by liquid chromatography coupled with ELSD detector revealed the presence of 12 saponins, identified according to compounds previously assayed in Chenopodium quinoa. Saponins found at the highest concentrations in raw grains were derived from oleanolic and phytolaccagenic acids. Total saponin concentration significantly decreased in germinated compared to raw grains due to the significant loss of 90.1% and 95.7% of the phytolaccagenic acid without and with chemical selenium stress, respectively. The most abundant saponin in germinated sprouts decreased during normal germination. Interestingly, the concentration of this particular saponin significantly increased during the Se-induced stress germination. Chemical stress with selenium salts proved to change the saponin composition in geminated Chenopodium berlandieri spp. grains, therefore affecting their potential use as ingredient in the food industry.
[Mh] Termos MeSH primário: Chenopodium/química
Saponinas/análise
Selênio/farmacologia
Triterpenos/análise
[Mh] Termos MeSH secundário: Chenopodium/efeitos dos fármacos
Chenopodium/crescimento & desenvolvimento
Germinação
Sementes/química
Sementes/efeitos dos fármacos
Sementes/crescimento & desenvolvimento
Selênio/análise
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Saponins); 0 (Triterpenes); H6241UJ22B (Selenium)
[Em] Mês de entrada:1608
[Cu] Atualização por classe:160111
[Lr] Data última revisão:
160111
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151210
[St] Status:MEDLINE
[do] DOI:10.1111/1750-3841.13174


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Fotocópia
[PMID]:26434121
[Au] Autor:Kokanova-Nedialkova Z; Kondeva-Burdina M; Zheleva-Dimitrova D; Tzankova V; Nikolov S; Heilmann J; Nedialkov PT
[Ti] Título:6-Methoxyflavonol Glycosides with In Vitro Hepatoprotective Activity from Chenopodium bonus-henricus Roots.
[So] Source:Nat Prod Commun;10(8):1377-80, 2015 Aug.
[Is] ISSN:1934-578X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:One new, namely 6-methoxykaempferol 3-O-[ß-apiofuranosyl(l-->2)]-f-glucopyranosyl(l->6)-fl-glucopyranoside (2), and two known flavonoid glycosides, spinacetin 3-O-[ß-apiofuranosyl(1-->2)]-ß-glucopyranosyl(1-->6)-ß-glucopyranoside (1) and spinacetin 3-O-gentiobioside (3), were isolated from the roots of Chenopodium bonus-henricus L. Their structures were determined by means of spectroscopic methods (ID, 2D NMR, UV, IR) and HR-ESI-MS. Radical scavenging and anti-oxidant activities of 1 and 3 were established using DPPH and ABTS free radicals, FRAP assay and inhibition of lipid peroxidation (LP) in a linoleic acid system by the ferric thiocyanate method. Compound 3 was found to possess stronger DPPH and ABTS radical scavenging activity (IC50 0.44 +/- 0.008 mM and 0.089 +/- 0.002 mM, respectively) compared with 1 (IC50 1.22 +/- 0.0 10 mM and 0.11 +/- 0.004 mM, respectively). Both flavonoids inhibited the lipid peroxidation of linoleic acid significantly. Additionally, 1 and 3 significantly reduced the cellular damage caused by the hepatotoxic agent CCI4 in rat hepatocytes and preserved cell viability and GSH level, decreased LDH leakage and reduced lipid damage. Effects were similar to those of the positive control silymarin. Control of self-toxic effects made in a MTT based assay using HepG2 cells revealed statistically significant cytotoxic effects only in very high concentrations (exceeding mM) and an incubation time of 72 h, making flavonoid glycosides with a 6-methoxykaempferol skeleton a promising and safe class of hepatoprotective compounds.
[Mh] Termos MeSH primário: Chenopodium/química
Flavonóis/farmacologia
Glicosídeos/farmacologia
Extratos Vegetais/farmacologia
Raízes de Plantas/química
Substâncias Protetoras/farmacologia
[Mh] Termos MeSH secundário: Animais
Sobrevivência Celular/efeitos dos fármacos
Células Cultivadas
Flavonóis/química
Glicosídeos/química
Células Hep G2
Hepatócitos/citologia
Hepatócitos/efeitos dos fármacos
Seres Humanos
Masculino
Extratos Vegetais/química
Substâncias Protetoras/química
Ratos
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Flavonols); 0 (Glycosides); 0 (Plant Extracts); 0 (Protective Agents)
[Em] Mês de entrada:1511
[Cu] Atualização por classe:151005
[Lr] Data última revisão:
151005
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151006
[St] Status:MEDLINE



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