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[PMID]:28589277
[Au] Autor:Tanveer M; Shah AN
[Ad] Endereço:School of Land and Food, University of Tasmania, Hobart, Australia. Mohsin.tanveer@utas.edu.au.
[Ti] Título:An insight into salt stress tolerance mechanisms of Chenopodium album.
[So] Source:Environ Sci Pollut Res Int;24(19):16531-16535, 2017 Jul.
[Is] ISSN:1614-7499
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Salt stress is one of the most dramatic abiotic stresses that induce oxidative and osmotic stress simultaneously. Salt stress is known to be more effective in reducing growth and yield of glycophytes; however, halophytes are able to withstand salt stress. Nonetheless, variability exists among different halophytic plants species from different plant families. Chenopodium album belongs to Chenopodiacea family and is known as weed in many regions of world; however, it is a very interesting halophytic plant. Little research has conducted so far by considering C. album as model plant to study salt stress tolerance mechanisms. This article attempts to compile current literature in order to explain C. album salt stress tolerance mechanism and to highlight the knowledge gap relating to salt stress tolerance mechanism in C. album. Briefly, C. album has remarkable ability of seed dimorphism, sodium exclusion, and potassium retention. C. album further tolerates salt stress by increasing redox potential associated with high production of osmolytes and antioxidants.
[Mh] Termos MeSH primário: Chenopodium album/fisiologia
Plantas Tolerantes a Sal
[Mh] Termos MeSH secundário: Tolerância a Sal
Sódio
Cloreto de Sódio
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
451W47IQ8X (Sodium Chloride); 9NEZ333N27 (Sodium)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171109
[Lr] Data última revisão:
171109
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170608
[St] Status:MEDLINE
[do] DOI:10.1007/s11356-017-9337-2


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[PMID]:27997185
[Au] Autor:Pernak J; Giszter R; Biedziak A; Niemczak M; Olszewski R; Marcinkowska K; Praczyk T
[Ad] Endereço:Department of Chemical Technology, Poznan University of Technology , Poznan 60-965, Poland.
[Ti] Título:Alkyl(C , C , C )trimethylammonium-Based Herbicidal Ionic Liquids.
[So] Source:J Agric Food Chem;65(2):260-269, 2017 Jan 18.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In the framework of this study a synthesis methodology and characterization of long alkyl herbicidal ionic liquids (HILs) based on four commonly used herbicides (2,4-D, MCPA, MCPP, and dicamba) are presented. New HILs were obtained with high efficiency (>95%) using an acid-base reaction between herbicidal acids and hexadecyltrimethylammonium, octadecyltrimethylammonium, and behenyltrimethylammonium hydroxides in alcoholic medium. Among all synthesized salts, only three compounds comprising the MCPP anion were liquids at room temperature. Subsequently, the influence of both the alkyl chain length and the anion structure on their physicochemical properties (thermal decomposition profiles, solubility in 10 representative solvents, surface activity, density, viscosity, and refractive index) was determined. All HILs exhibited high thermal stability as well as surface activity; however, their solubility notably depended on both the length of the carbon chain and the structure of the anion. The herbicidal efficacy of the obtained salts was tested in greenhouse and field experiments. Greenhouse testing performed on common lambsquarters (Chenopodium album L.) and flixweed (Descurainia sophia L.) as test plants indicated that HILs were characterized by similar or higher efficacy compared to commercial herbicides. The results of field trials confirmed the high activity of HILs, particularly those containing phenoxyacids as anions (MCPA, 2,4-D, and MCPP).
[Mh] Termos MeSH primário: Herbicidas/química
Herbicidas/farmacologia
Líquidos Iônicos/química
[Mh] Termos MeSH secundário: Ácido 2,4-Diclorofenoxiacético/química
Ácido 2-Metil-4-clorofenoxiacético/química
Compostos de Bis-Trimetilamônio/química
Brassicaceae/efeitos dos fármacos
Técnicas de Química Sintética
Chenopodium album/efeitos dos fármacos
Dicamba/química
Herbicidas/síntese química
Líquidos Iônicos/síntese química
Líquidos Iônicos/farmacologia
Plantas Daninhas/efeitos dos fármacos
Polônia
Solubilidade
Relação Estrutura-Atividade
Propriedades de Superfície
Viscosidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Bis-Trimethylammonium Compounds); 0 (Herbicides); 0 (Ionic Liquids); 2577AQ9262 (2,4-Dichlorophenoxyacetic Acid); D888C394VO (2-Methyl-4-chlorophenoxyacetic Acid); SJG3M6RY6H (Dicamba)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170502
[Lr] Data última revisão:
170502
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161221
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.6b04528


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[PMID]:27864113
[Au] Autor:Sikarwar I; Dey YN; Wanjari MM; Sharma A; Gaidhani SN; Jadhav AD
[Ad] Endereço:Shri Ram College of Pharmacy, Banmore 474 011, Madhya Pradesh, India.
[Ti] Título:Chenopodium album Linn. leaves prevent ethylene glycol-induced urolithiasis in rats.
[So] Source:J Ethnopharmacol;195:275-282, 2017 Jan 04.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:ETHNOPHARMACOLOGICAL RELEVANCE: The leaves of Chenopodium album Linn. are traditionally used for correction of kidney diseases and urinary stones. The present work investigated the effect of methanolic and aqueous extracts of leaves of Chenopodium album on experimentally-induced urolithiasis in rats to substantiate its traditional use as antilithiatic agent. MATERIALS AND METHODS: The leaf extract was standardized by HPLC. Urolithiasis was induced in rats by administration of 0.75% v/v of ethylene glycol (EG) in distilled water and in addition, vehicle or methanol (CAME) or aqueous (CAAE) extract of the leaves of Chenopodium album each in the dose 100, 200 and 400mg/kg or Cystone (750mg/kg) were administered daily orally for 28 days. Urolithiasis was assessed by estimating the calcium, phosphorus, urea, uric acid, and creatinine in both urine and plasma. The volume, pH and oxalate levels were also estimated in urine. The renal oxalate content was estimated in kidney while calcium oxalate deposits were observed histologically. RESULTS: The treatment with CAME or CAAE for 28 days significantly attenuated the EG-induced elevations in the urine and plasma levels of calcium, phosphorus, urea, uric acid and creatinine along with decrease in urine volume, pH and oxalates. The treatments also decreased renal tissue oxalate and deposition of oxalate crystals in kidney due to EG treatment. The effects of CAME and CAAE were comparable to standard antilithiatic agent, cystone. The findings indicate the preventive effect of CAME and CAAE which can be due to inhibitory effect on crystallization and stone dissolution. The effect was attributed to the presence of phytochemicals like flavonoids and saponins. CONCLUSION: In conclusion, Chenopodium album leaves exhibited antilithiatic effect and validates its ethnomedicinal use in urinary disorders and kidney stones.
[Mh] Termos MeSH primário: Chenopodium album/química
Etilenoglicol
Rim/efeitos dos fármacos
Extratos Vegetais/farmacologia
Folhas de Planta/química
Urolitíase/prevenção & controle
Agentes Urológicos/farmacologia
[Mh] Termos MeSH secundário: Animais
Biomarcadores/sangue
Biomarcadores/urina
Cromatografia Líquida de Alta Pressão
Cristalização
Modelos Animais de Doenças
Feminino
Flavonoides/isolamento & purificação
Flavonoides/farmacologia
Rim/metabolismo
Rim/fisiopatologia
Masculino
Metanol/química
Fitoterapia
Extratos Vegetais/isolamento & purificação
Extratos Vegetais/toxicidade
Plantas Medicinais
Ratos Wistar
Saponinas/isolamento & purificação
Saponinas/farmacologia
Solventes/química
Fatores de Tempo
Micção/efeitos dos fármacos
Urolitíase/sangue
Urolitíase/induzido quimicamente
Urolitíase/urina
Agentes Urológicos/isolamento & purificação
Agentes Urológicos/toxicidade
Água/química
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Flavonoids); 0 (Plant Extracts); 0 (Saponins); 0 (Solvents); 0 (Urological Agents); 0 (cystone); 059QF0KO0R (Water); FC72KVT52F (Ethylene Glycol); Y4S76JWI15 (Methanol)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170703
[Lr] Data última revisão:
170703
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161120
[St] Status:MEDLINE


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[PMID]:28375121
[Au] Autor:Shad AA; Bakht J; Shah HU; Hayat Y
[Ad] Endereço:Department of Agric. Chemistry, The University of Agriculture Peshawar, KPK Pakistan.
[Ti] Título:Antioxidant activity and nutritional assessment of under-utilized medicinal plants.
[So] Source:Pak J Pharm Sci;29(6):2039-2045, 2016 Nov.
[Is] ISSN:1011-601X
[Cp] País de publicação:Pakistan
[La] Idioma:eng
[Ab] Resumo:The present study investigates the nutritive and anti-nutritive composition of six species (Allium porrum, Amaranthus spinosis, Apium graveolens, Caralluma edulis, Chenopodium album, Urtica dioica). The studied species contained considerable amount of crude protein (4.53-11.41%), crude fat (1.25-3.74%), vitamin C (7.85-28.09mg 100 g) and ß-Carotene (18.29-169.33mg 100 g). The mineral profile of Chenopodium album is considered as potential source of Zn (14.51±1.14mg 100-1g), Mn (67.71±0.85mg 100 g), Se (8.45±0.49mg 100 g) and Fe (182.08±1.52mg 100-1g) and Caralluma edulis as potential source of Fe (7.28± 0.03mg 100 g). Ca and P content ranged 63-306mg 100 g and 12-392mg 100 g in all studied plants with exceptionally high level was found in Chenopodium album (1084mg 100-1g) and (3924mg 100 g), respectively. Similarly, total phenol, tannin and phytic acid were found in the range of 105-354, 5-90 and 10-85mg 100 g, respectively. Total oxalates and soluble oxalates contents were below 200mg 100 g in five examined plants with the exception of Chenopodium album (413mg 100 g). Antioxidant activity of Caralluma edulis was found maximum while the rest of the examined plants had moderate levels.
[Mh] Termos MeSH primário: Amaranthus/química
Antioxidantes/farmacologia
Apium graveolens/química
Apocynaceae/química
Chenopodium album/química
Valor Nutritivo
Cebolas/química
Compostos Fitoquímicos/farmacologia
Extratos Vegetais/farmacologia
Urtica dioica/química
[Mh] Termos MeSH secundário: Antioxidantes/química
Antioxidantes/isolamento & purificação
Compostos de Bifenilo/química
Gorduras/análise
Minerais/análise
Compostos Fitoquímicos/química
Compostos Fitoquímicos/isolamento & purificação
Fitoterapia
Picratos/química
Extratos Vegetais/química
Extratos Vegetais/isolamento & purificação
Proteínas de Plantas/análise
Plantas Medicinais
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Biphenyl Compounds); 0 (Fats); 0 (Minerals); 0 (Phytochemicals); 0 (Picrates); 0 (Plant Extracts); 0 (Plant Proteins); DFD3H4VGDH (1,1-diphenyl-2-picrylhydrazyl)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171103
[Lr] Data última revisão:
171103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170405
[St] Status:MEDLINE


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[PMID]:27513342
[Au] Autor:Krak K; Vít P; Belyayev A; Douda J; Hreusová L; Mandák B
[Ad] Endereço:Institute of Botany, Czech Academy of Sciences, Zámek 1, CZ-252 43, Pruhonice, Czech Republic.
[Ti] Título:Allopolyploid Origin of Chenopodium album s. str. (Chenopodiaceae): A Molecular and Cytogenetic Insight.
[So] Source:PLoS One;11(8):e0161063, 2016.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Reticulate evolution is characterized by occasional hybridization between two species, creating a network of closely related taxa below and at the species level. In the present research, we aimed to verify the hypothesis of the allopolyploid origin of hexaploid C. album s. str., identify its putative parents and estimate the frequency of allopolyploidization events. We sampled 122 individuals of the C. album aggregate, covering most of its distribution range in Eurasia. Our samples included putative progenitors of C. album s. str. of both ploidy levels, i.e. diploids (C. ficifolium, C. suecicum) and tetraploids (C. striatiforme, C. strictum). To fulfil these objectives, we analysed sequence variation in the nrDNA ITS region and the rpl32-trnL intergenic spacer of cpDNA and performed genomic in-situ hybridization (GISH). Our study confirms the allohexaploid origin of C. album s. str. Analysis of cpDNA revealed tetraploids as the maternal species. In most accessions of hexaploid C. album s. str., ITS sequences were completely or nearly completely homogenized towards the tetraploid maternal ribotype; a tetraploid species therefore served as one genome donor. GISH revealed a strong hybridization signal on the same eighteen chromosomes of C. album s. str. with both diploid species C. ficifolium and C. suecicum. The second genome donor was therefore a diploid species. Moreover, some individuals with completely unhomogenized ITS sequences were found. Thus, hexaploid individuals of C. album s. str. with ITS sequences homogenized to different degrees may represent hybrids of different ages. This proves the existence of at least two different allopolyploid lineages, indicating a polyphyletic origin of C. album s. str.
[Mh] Termos MeSH primário: Chenopodium album/genética
Análise Citogenética/métodos
DNA de Plantas/genética
Evolução Molecular
Variação Genética/genética
Poliploidia
[Mh] Termos MeSH secundário: Genômica
Filogenia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Plant)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170803
[Lr] Data última revisão:
170803
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160812
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0161063


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[PMID]:27467750
[Au] Autor:Bühler M; Bogenrieder A; Sandermann H; Ernst D
[Ti] Título:Heteroplasmy and atrazine resistance in Chenopodium album and Senecio vulgaris.
[So] Source:Z Naturforsch C;71(7-8):267-72, 2016.
[Is] ISSN:0939-5075
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Atrazine-resistant weeds are well known, and the resistance is primarily caused by a point mutation in the psbA chloroplast gene encoding the photosystem II D1 protein. Heteroplasmy, the presence of different types of chloroplasts in an individual plant, is also very common. Thus, atrazine-resistant weeds may also partly possess the atrazine-binding sequence and vice versa. The region of the psbA gene containing the mutation was sequenced from atrazine-resistant and atrazine-sensitive Chenopodium album and Senecio vulgaris plants. In atrazine-sensitive C. album plants, the expected AGT triplet was found. The atrazine-resistant plants contained the expected base substitution (AGT to GGT); however, in addition the AGT triplet was found. The atrazine-resistant S. vulgaris plants contained the expected GGT sequence, whereas the atrazine-sensitive plants contained both the AGT and GGT sequences. This clearly indicates that in addition to Gly264 also Ser264 is present in atrazine-resistant plants, and vice versa in atrazine-sensitive plants, indicating heteroplasmy in these weeds.
[Mh] Termos MeSH primário: Atrazina/farmacologia
Chenopodium album/genética
DNA de Cloroplastos/genética
Resistência a Medicamentos/genética
Variação Genética
Senécio/genética
[Mh] Termos MeSH secundário: Substituição de Aminoácidos
Sequência de Bases
DNA de Cloroplastos/química
Glicina/genética
Herbicidas/farmacologia
Complexo de Proteína do Fotossistema II/genética
Mutação Puntual
Análise de Sequência de DNA
Serina/genética
Especificidade da Espécie
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Chloroplast); 0 (Herbicides); 0 (Photosystem II Protein Complex); 452VLY9402 (Serine); QJA9M5H4IM (Atrazine); TE7660XO1C (Glycine)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170113
[Lr] Data última revisão:
170113
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160729
[St] Status:MEDLINE


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[PMID]:27040822
[Au] Autor:Nouri HR; Karkhah A; Varasteh A; Sankian M
[Ad] Endereço:Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.
[Ti] Título:Expression of a Chimeric Allergen with High Rare Codons Content in Codon Bias-Adjusted Escherichia coli: Escherichia coli BL21 (DE3)-Codon Plus RIL as an Efficient Host.
[So] Source:Curr Microbiol;73(1):91-8, 2016 Jul.
[Is] ISSN:1432-0991
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The expression of heterologous proteins in Escherichia coli (E. coli) is importantly affected by codon bias. Hence, the aim of the current study was to determine which codon bias-adjusted E. coli strain is sufficient for expression of a chimeric allergen coded by high rare codon content. To investigate the expression level, a chimeric protein of Chenopodium album (C. album) was used as an appropriate model. An expression construct was assembled and was transformed to four strains of codon bias-adjusted E. coli including origami, BL21 (DE3), BL21 (DE3)-codon plus RIL, and Rosetta. The level of expression and solubility of the chimeric allergen was analyzed by SDS-PAGE. In addition, the allergenicity of chimeric allergen was determined using immunoblotting. Our results showed that the chimeric allergen was expressed at high level in E. coli BL21 (DE3)-codon plus RIL and Rosetta. In detail, this recombinant allergen was isolated from soluble fraction in the codon bias-adjusted strains of E. coli BL21 (DE3)-codon plus RIL and Rosetta. Moreover, some lower molecular weight proteins were observed in Rosetta, which could be related to inappropriate expression or broken compartments of the chimeric allergen. The immunoblotting assay confirmed that the IgE-specific immune reactivity of our chimeric allergen expressed in BL21 (DE3)-codon plus RIL was significantly higher than the other strains. Our results showed that the expression of the chimeric allergen with high rare codons content in a codon bias-adjusted strain E. coli BL21 (DE3)-codon plus RIL improves the quality and solubility of the heterologous protein production.
[Mh] Termos MeSH primário: Alérgenos/genética
Antígenos de Plantas/genética
Chenopodium album/genética
Códon/genética
Escherichia coli/genética
Proteínas de Plantas/genética
Engenharia de Proteínas
[Mh] Termos MeSH secundário: Alérgenos/metabolismo
Antígenos de Plantas/metabolismo
Códon/metabolismo
Escherichia coli/metabolismo
Expressão Gênica
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Allergens); 0 (Antigens, Plant); 0 (Codon); 0 (Plant Proteins)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170926
[Lr] Data última revisão:
170926
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160405
[St] Status:MEDLINE
[do] DOI:10.1007/s00284-016-1027-7


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[PMID]:26765354
[Au] Autor:Kordali S; Usanmaz A; Cakir A; Komaki A; Ercisli S
[Ad] Endereço:Ataturk University, Faculty of Agriculture, Department of Plant Protection, TR-25240 Erzurum.
[Ti] Título:Antifungal and Herbicidal Effects of Fruit Essential Oils of Four Myrtus communis Genotypes.
[So] Source:Chem Biodivers;13(1):77-84, 2016 Jan.
[Is] ISSN:1612-1880
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:The chemical composition of the essential oils isolated by hydrodistillation from the fruits of four selected Myrtus communis L. genotypes from Turkey was characterized by GC-FID and GC/MS analyses. 1,8-Cineole (29.20-31.40%), linalool (15.67-19.13%), α-terpineol (8.40-18.43%), α-pinene (6.04-20.71%), and geranyl acetate (3.98-7.54%) were found to be the major constituents of the fruit essential oils of all M. communis genotypes investigated. The oils were characterized by high amounts of oxygenated monoterpenes, representing 73.02-83.83% of the total oil compositions. The results of the fungal growth inhibition assays showed that the oils inhibited the growth of 19 phytopathogenic fungi. However, their antifungal activity was generally lower than that of the commercial pesticide benomyl. The herbicidal effects of the oils on the seed germination and seedling growth of Amaranthus retroflexus L., Chenopodium album L., Cirsium arvense (L.) Scop., Lactuca serriola L., and Rumex crispus L. were also determined. The oils completely or partly inhibited the seed germinations and seedling growths of the plants. The findings of the present study suggest that the M. communis essential oils might have potential to be used as natural herbicides as well as fungicides.
[Mh] Termos MeSH primário: Antifúngicos/farmacologia
Frutas/química
Fungos/efeitos dos fármacos
Herbicidas/farmacologia
Myrtus/química
Myrtus/genética
Óleos Voláteis/farmacologia
Sementes/efeitos dos fármacos
[Mh] Termos MeSH secundário: Amaranthus/efeitos dos fármacos
Amaranthus/crescimento & desenvolvimento
Antifúngicos/química
Antifúngicos/isolamento & purificação
Chenopodium album/efeitos dos fármacos
Chenopodium album/crescimento & desenvolvimento
Cirsium/efeitos dos fármacos
Cirsium/crescimento & desenvolvimento
Genótipo
Herbicidas/química
Herbicidas/isolamento & purificação
Alface/efeitos dos fármacos
Alface/crescimento & desenvolvimento
Estrutura Molecular
Óleos Voláteis/química
Óleos Voláteis/isolamento & purificação
Rumex/efeitos dos fármacos
Rumex/crescimento & desenvolvimento
Sementes/crescimento & desenvolvimento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antifungal Agents); 0 (Herbicides); 0 (Oils, Volatile)
[Em] Mês de entrada:1610
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160115
[St] Status:MEDLINE
[do] DOI:10.1002/cbdv.201500018


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[PMID]:26375852
[Au] Autor:Backes M; Obst K; Bojahr J; Thorhauer A; Roudnitzky N; Paetz S; Reichelt KV; Krammer GE; Meyerhof W; Ley JP
[Ad] Endereço:Symrise AG , Flavors Division, Research & Technology, P.O. Box 1253, 37603 Holzminden, Germany.
[Ti] Título:Rubemamine and Rubescenamine, Two Naturally Occurring N-Cinnamoyl Phenethylamines with Umami-Taste-Modulating Properties.
[So] Source:J Agric Food Chem;63(39):8694-704, 2015 Oct 07.
[Is] ISSN:1520-5118
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Sensory screening of a series of naturally occurring N-cinnamoyl derivatives of substituted phenethylamines revealed that rubemamine (9, from Chenopodium album) and rubescenamine (10, from Zanthoxylum rubsecens) elicit strong intrinsic umami taste in water at 50 and 10 ppm, respectively. Sensory tests in glutamate- and nucleotide-containing bases showed that the compounds influence the whole flavor profile of savory formulations. Both rubemamine (9) and rubescenamine (10) at 10-100 ppm dose-dependently positively modulated the umami taste of MSG (0.17-0.22%) up to threefold. Among the investigated amides, only rubemamine (9) and rubescenamine (10) are able to directly activate the TAS1R1-TAS1R3 umami taste receptor. Moreover, both compounds also synergistically modulated the activation of TAS1R1-TAS1R3 by MSG. Most remarkably, rubemamine (9) was able to further positively modulate the IMP-enhanced TAS1R1-TAS1R3 response to MSG ∼ 1.8-fold. Finally, armatamide (11), zanthosinamide (13), and dioxamine (14), which lack intrinsic umami taste in vivo and direct receptor response in vitro, also positively modulated receptor activation by MSG about twofold and the IMP-enhanced MSG-induced TAS1R1-TAS1R3 responses approximately by 50%. In sensory experiments, dioxamine (14) at 25 ppm in combination with 0.17% MSG exhibited a sensory equivalent to 0.37% MSG.
[Mh] Termos MeSH primário: Chenopodium album/química
Aromatizantes/química
Fenetilaminas/química
Extratos Vegetais/química
Glutamato de Sódio/metabolismo
Zanthoxylum/química
[Mh] Termos MeSH secundário: Aromatizantes/síntese química
Aromatizantes/metabolismo
Seres Humanos
Estrutura Molecular
Fenetilaminas/síntese química
Fenetilaminas/metabolismo
Extratos Vegetais/síntese química
Extratos Vegetais/metabolismo
Receptores Acoplados a Proteínas-G/metabolismo
Paladar
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Flavoring Agents); 0 (Phenethylamines); 0 (Plant Extracts); 0 (Receptors, G-Protein-Coupled); 0 (taste receptors, type 1); W81N5U6R6U (Sodium Glutamate)
[Em] Mês de entrada:1604
[Cu] Atualização por classe:151007
[Lr] Data última revisão:
151007
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150917
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jafc.5b04402


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[PMID]:26226110
[Au] Autor:Evidente M; Cimmino A; Zonno MC; Masi M; Berestetskyi A; Santoro E; Superchi S; Vurro M; Evidente A
[Ad] Endereço:Department of Chemical Sciences, University of Naples "Federico II", Complesso Universitario Monte S. Angelo, Via Cintia 4, 80126 Napoli, Italy.
[Ti] Título:Phytotoxins produced by Phoma chenopodiicola, a fungal pathogen of Chenopodium album.
[So] Source:Phytochemistry;117:482-8, 2015 Sep.
[Is] ISSN:1873-3700
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Two phytotoxins were isolated from the liquid culture of Phoma chenopodiicola, a fungal pathogen proposed for the biological control of Chenopodium album, a common worldwide weed of arable crops. The two phytotoxins appeared to be a new tetrasubstituted furopyran and a new ent-pimaradiene. From the same culture a new tetrasubstituted isocoumarin was also isolated. These compounds were characterized by using spectroscopic (essentially 1D and 2D NMR and HR ESI MS) and chemical methods as 3-(3-methoxy-2,6-dimethyl-7aH-furo[2,3-b]pyran-4-yl)-but-2-en-1-ol (chenopodolan D, 1) (1S,2S,3S,4S,5S,9R,10S,12S,13S)-1,3,12-triacetoxy-2,hydroxy-6-oxo-ent-pimara-7(8),15-dien-18-oic acid 2,18-lactone (chenopodolin B, 3), and, 4,5,7-trihydroxy-3-methyl-isochroman-1-one (chenisocoumarin, 2) The absolute configuration of chenisocoumarin was assigned by applying an advanced Mosher's method through the derivatization of its secondary hydroxylated carbon C-4, while that of chenopodolan D by application of quantum mechanical calculations of chiroptical (ECD and ORD) properties. When assayed by leaf puncture against non-host weeds, chenopodolan D and chenopodolin B showed phytotoxicity while chenisocoumarin and the 9-O-acetyl derivative of chenopodolan D were inactive. These results confirm that the nature of the side chain at C-4 in chenopodolans, and in particular its hydroxylation, are important features for activity. The activity of chenopodolin B could also be explained by its possible hydrolysis to chenopodolin.
[Mh] Termos MeSH primário: Ascomicetos/química
Ascomicetos/metabolismo
Herbicidas/farmacologia
Micotoxinas/química
Micotoxinas/farmacologia
[Mh] Termos MeSH secundário: Ascomicetos/patogenicidade
Chenopodium album/microbiologia
Diterpenos Abietanos/química
Diterpenos Abietanos/farmacologia
Furanos/química
Furanos/farmacologia
Herbicidas/química
Isocumarinas/química
Isocumarinas/farmacologia
Espectroscopia de Ressonância Magnética
Estrutura Molecular
Micotoxinas/metabolismo
Folhas de Planta/efeitos dos fármacos
Plantas Daninhas/efeitos dos fármacos
Piranos/química
Piranos/farmacologia
Espectrometria de Massas por Ionização por Electrospray
Relação Estrutura-Atividade
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (1,3,12-triacetoxy-2-hydroxy-6-oxopimara-7(8),15-dien-18-oic acid 2,18-lactone); 0 (3-(3-methoxy-2,6-dimethyl-7aH-furo(2,3-b)pyran-4-yl)-but-2-en-1-ol); 0 (4,5,7-trihydroxy-3-methylisochroman-1-one); 0 (Diterpenes, Abietane); 0 (Furans); 0 (Herbicides); 0 (Isocoumarins); 0 (Mycotoxins); 0 (Pyrans)
[Em] Mês de entrada:1606
[Cu] Atualização por classe:150828
[Lr] Data última revisão:
150828
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150731
[St] Status:MEDLINE



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