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[PMID]:27492200
[Au] Autor:Cysne DN; Fortes TS; Reis AS; de Paulo Ribeiro B; Dos Santos Ferreira A; do Amaral FM; Guerra RN; Marinho CR; Nicolete R; Nascimento FR
[Ad] Endereço:Laboratory of Immunophysiology, Department of Pathology, Center for Biological and Health Sciences, Federal University of Maranhão (UFMA), 65080-805, São Luís, Brazil.
[Ti] Título:Antimalarial potential of leaves of Chenopodium ambrosioides L.
[So] Source:Parasitol Res;115(11):4327-4334, 2016 Nov.
[Is] ISSN:1432-1955
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:In an effort to identify novel therapeutic alternatives for the treatment of malaria, the present study evaluated the antimalarial effect of the crude hydroalcoholic extract (HCE) from the leaves of Chenopodium ambrosioides L. For this purpose, the molecular affinity between the total proteins from erythrocytes infected with Plasmodium falciparum and HCE or chloroquine was evaluated by surface plasmon resonance (SPR). Subsequently, the plasmodicidal potential of HCE was assessed in a P. falciparum culture. Using BALB/c mice infected with Plasmodium berghei intraperitoneally (ip.), we evaluated the effects of ip. treatment, for three consecutive days (day 7, 8, and 9 after infection), with chloroquine (45 mg/kg) or HCE (5 mg/kg), considering the survival index and the parasitaemia. The groups were compared to an untreated control group that receives only PBS at the same periods. The results indicated that HCE could bind to the total proteins of infected erythrocytes and could inhibit the parasite growth in vitro (IC = 25.4 g/mL). The in vivo therapeutic treatment with HCE increased the survival and decreased the parasitaemia in the infected animals. Therefore, the HCE treatment exhibited a significant antiplasmodial effect and may be considered as a potential candidate for the development of new antimalarial drugs.
[Mh] Termos MeSH primário: Antimaláricos/farmacologia
Chenopodium ambrosioides/química
Malária/tratamento farmacológico
Parasitemia/tratamento farmacológico
Extratos Vegetais/farmacologia
Plasmodium berghei/efeitos dos fármacos
Plasmodium falciparum/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Cloroquina/farmacologia
Eritrócitos/parasitologia
Seres Humanos
Camundongos
Camundongos Endogâmicos BALB C
Folhas de Planta/metabolismo
Ressonância de Plasmônio de Superfície
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antimalarials); 0 (Plant Extracts); 886U3H6UFF (Chloroquine)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:171007
[Lr] Data última revisão:
171007
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160806
[St] Status:MEDLINE


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[PMID]:27209428
[Au] Autor:Moura Mdel G; Lopes LC; Biavatti MW; Busse JW; Wang L; Kennedy SA; Bhatnaga N; Bergamaschi Cde C
[Ad] Endereço:Department of Pharmaceutical Sciences, University of Sorocaba, Sorocaba, São Paulo, Brazil.
[Ti] Título:Brazilian oral herbal medication for osteoarthritis: a systematic review protocol.
[So] Source:Syst Rev;5:86, 2016 May 21.
[Is] ISSN:2046-4053
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Osteoarthritis affects 1 % of the world's population and is the most common cause of musculoskeletal impairment in the elderly. Herbal medications are commonly used in Brazil to manage symptoms associated with osteoarthritis, and some of them are financed by the Brazilian government; however, the effectiveness of most of these agents is uncertain. The aim was to systematically review the efficacy and safety of 13 oral herbal medications used in Brazil for the treatment of osteoarthritis. METHODS: Randomized clinical trials eligible for our systematic review will enroll adults with osteoarthritis treated by a Brazilian herbal medication or a control group (placebo or active control). Using terms to include all forms of osteoarthritis combined with herbal medications, we will search the following electronic databases: Cochrane Central Register of Controlled Trials (CENTRAL); MEDLINE; EMBASE; CINAHL; Web of Science; Health Star; AMED, the database of the Cochrane Complementary Medicine Field, LILACS; CAB abstracts, Clinical trial.gov, WHO trials registry, and Bank of Brazil Thesis (CAPES), to 31 January 2016, without restrictions concerning language or status of publication. Outcomes of interest include the following: symptom relief (e.g., pain), adverse events (gastrointestinal bleeding, epigastric pain, nausea, and allergic reactions), discontinuation due to adverse events, quality of life, and the satisfaction with the treatment. Dichotomous data will be summarized as risk ratios; continuous data will be given as standard average differences with 95 % confidence intervals. A team of reviewers will assess each citation independently for eligibility and in duplicate it. For eligible studies, the same reviewers will perform data extraction, bias risk assessment, and determination of the overall quality of evidence for each of the outcomes using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) classification system. DISCUSSION: This is the first study that will evaluate the use of herbal medications used in Brazil for the treatment of pain caused by osteoarthritis. The results could guide prescribers in decision-making in clinical practice, to inform the patients with pain caused by osteoarthritis in relation to effective and safe treatment options and to inform the managers of the public health system which of the plants could actually be financed by the Brazilian government. SYSTEMATIC REVIEW REGISTRATION: PROSPERO 42015019793.
[Mh] Termos MeSH primário: Osteoartrite/tratamento farmacológico
Fitoterapia
Preparações de Plantas/uso terapêutico
[Mh] Termos MeSH secundário: Boswellia
Brasil
Unha-de-Gato
Chenopodium ambrosioides
Cordia
Curcuma
Fabaceae
Harpagophytum
Seres Humanos
Persea
Salix
Resultado do Tratamento
Uncaria
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; REVIEW
[Nm] Nome de substância:
0 (Plant Preparations)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160523
[St] Status:MEDLINE
[do] DOI:10.1186/s13643-016-0261-1


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[PMID]:26696389
[Au] Autor:Xue S; Zhu F; Wu C; Lei J; Hartley W; Pan W
[Ad] Endereço:a School of Metallurgy and Environment, Central South University , Changsha , PR China.
[Ti] Título:Effects of manganese on the microstructures of Chenopodium ambrosioides L., A manganese tolerant plant.
[So] Source:Int J Phytoremediation;18(7):710-9, 2016.
[Is] ISSN:1549-7879
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Chenopodium ambrosioides L. can tolerate high concentrations of manganese and has potential for its use in the revegetation of manganese mine tailings. Following a hydroponic investigation, transmission electron microscopy (TEM)-energy disperse spectroscopy (EDS) was used to study microstructure changes and the possible accumulation of Mn in leaf cells of C. ambrosioides in different Mn treatments (200, 1000, 10000 µmol·L(-1)). At 200 µmol·L(-1), the ultrastructure of C. ambrosioides was clearly visible without any obvious damage. At 1000 µmol·L(-1), the root, stem and leaf cells remained intact, and the organelles were clearly visible without any obvious damage. However, when the Mn concentration exceeded 1000 µmol·L(-1) the number of mitochondria in root cells decreased and the chloroplasts in stem cells showed a decrease in grana lamellae and osmiophilic granules. Compared to controls, treatment with 1000 µmol·L(-1) or 10000 µmol·L(-1) Mn over 30 days, gave rise to black agglomerations in the cells. At 10000 µmol·L(-1), Mn was observed to form acicular structures in leaf cells and intercellular spaces, which may be a form of tolerance and accumulation of Mn in C. ambrosioides. This study has furthered the understanding of Mn tolerance mechanisms in plants, and is potential for the revegetation of Mn-polluted soils.
[Mh] Termos MeSH primário: Chenopodium ambrosioides/efeitos dos fármacos
Manganês/metabolismo
Poluentes do Solo/metabolismo
[Mh] Termos MeSH secundário: Biodegradação Ambiental
Chenopodium ambrosioides/metabolismo
Chenopodium ambrosioides/ultraestrutura
Hidroponia
Microscopia Eletrônica de Transmissão
Folhas de Planta/efeitos dos fármacos
Folhas de Planta/metabolismo
Folhas de Planta/ultraestrutura
Espectrometria por Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Soil Pollutants); 42Z2K6ZL8P (Manganese)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151224
[St] Status:MEDLINE
[do] DOI:10.1080/15226514.2015.1131233


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Carvalho, Rejane Andrade de
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[PMID]:26735052
[Au] Autor:Soares CD; Carvalho MG; Carvalho RA; Trindade SR; Rêgo AC; Araújo-Filho I; Marques MM
[Ad] Endereço:Department of Dentistry, Universidade Potiguar, Natal, RN, Brazil.
[Ti] Título:Chenopodium ambrosioides L. extract prevents bone loss.
[So] Source:Acta Cir Bras;30(12):812-8, 2015 Dec.
[Is] ISSN:1678-2674
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:PURPOSE: To evaluate the effect of the Chenopodium ambrosioides L (mastruz) extract for preventing bone loss and bone metabolism in ovariectomized rats. METHODS: Twelve rats were subjected to bilateral ovariectomy for inducing osteoporosis. After surgery, they were divided into two groups: Ovariectomy-control group (G1, n=6), receiving 0.5 ml distilled water by gavage for 30 days, and Ovariectomy plus mastruz group (G2, n=6), receiving 0.5 ml of the hydroalcoholic extract of mastruz at 10% concentration (50mg) daily, for the same period. Then, the blood of the animals was collected for further biochemical analysis (liver function) and tibia and liver were removed for histological and histomorphometric analyses. RESULTS: The cortical bone was significantly larger in the G2 than G1, whereas G1 presented the highest amount of adipocytes in the bone marrow (p<0.05). The blood levels of aspartate aminotransferase, triglycerides and cholesterol were significantly higher, whereas globulin and lactate dehydrogenase were smaller in G2 than G1. CONCLUSION: The hydroalcoholic extract of mastruz has effects on bone metabolism by changing blood proteins and enzymes and preventing both bone loss and the substitution of bone marrow cells by.
[Mh] Termos MeSH primário: Densidade Óssea/efeitos dos fármacos
Chenopodium ambrosioides/química
Osteoporose/prevenção & controle
Fitoterapia/métodos
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Adipócitos/ultraestrutura
Animais
Aspartato Aminotransferases/sangue
Células da Medula Óssea/metabolismo
Osso e Ossos/efeitos dos fármacos
Osso e Ossos/metabolismo
Colesterol/sangue
Feminino
Fêmur/ultraestrutura
Modelos Animais
Osteoporose/etiologia
Ovariectomia/efeitos adversos
Ratos Wistar
Triglicerídeos/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Plant Extracts); 0 (Triglycerides); 97C5T2UQ7J (Cholesterol); EC 2.6.1.1 (Aspartate Aminotransferases)
[Em] Mês de entrada:1606
[Cu] Atualização por classe:161020
[Lr] Data última revisão:
161020
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160107
[St] Status:MEDLINE


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[PMID]:26524084
[Au] Autor:Calado GP; Lopes AJ; Costa Junior LM; Lima Fd; Silva LA; Pereira WS; Amaral FM; Garcia JB; Cartágenes Mdo S; Nascimento FR
[Ad] Endereço:Health Sciences Graduate Program, Federal University of Maranhao, Biologic and Health Sciences Center, Av. dos Portugueses 1966, São Luís, MA, CEP:65085-580, Brazil.
[Ti] Título:Chenopodium ambrosioides L. Reduces Synovial Inflammation and Pain in Experimental Osteoarthritis.
[So] Source:PLoS One;10(11):e0141886, 2015.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The chronicity of osteoarthritis (OA), characterized by pain and inflammation in the joints, is linked to a glutamate receptor, N-methyl-D-aspartate (NMDA). The use of plant species such as Chenopodium ambrosioides L. (Amaranthaceae) as NMDA antagonists offers a promising perspective. This work aims to analyze the antinociceptive and anti-inflammatory responses of the crude hydroalcoholic extract (HCE) of C. ambrosioides leaves in an experimental OA model. Wistar rats were separated into six groups (n = 24): clean (C), negative control (CTL-), positive control (CTL+), HCE0.5, HCE5 and HCE50. The first group received no intervention. The other groups received an intra-articular injection of sodium monoiodoacetate (MIA) (8 mg/kg) on day 0. After six hours, they were orally treated with saline, Maxicam plus (meloxicam + chondroitin sulfate) and HCE at doses of 0.5 mg/kg, 5 mg/kg and 50 mg/kg, respectively. After three, seven and ten days, clinical evaluations were performed (knee diameter, mechanical allodynia, mechanical hyperalgesia and motor activity). On the tenth day, after euthanasia, synovial fluid and draining lymph node were collected for cellular quantification, and cartilage was collected for histopathological analysis. Finally, molecular docking was performed to evaluate the compatibility of ascaridole, a monoterpene found in HCE, with the NMDA receptor. After the third day, HCE reduced knee edema. HCE5 showed less cellular infiltrate in the cartilage and synovium and lower intensities of allodynia from the third day and of hyperalgesia from the seventh day up to the last treatment day. The HCE5 and HCE50 groups improved in forced walking. In relation to molecular docking, ascaridole showed NMDA receptor binding affinity. C. ambrosioides HCE was effective in the treatment of OA because it reduced synovial inflammation and behavioral changes due to pain. This effect may be related to the antagonistic effect of ascaridole on the NMDA receptor.
[Mh] Termos MeSH primário: Chenopodium ambrosioides/química
Osteoartrite/tratamento farmacológico
Dor/tratamento farmacológico
Extratos Vegetais/administração & dosagem
Receptores de N-Metil-D-Aspartato/antagonistas & inibidores
[Mh] Termos MeSH secundário: Analgésicos/administração & dosagem
Analgésicos/farmacologia
Animais
Anti-Inflamatórios/administração & dosagem
Anti-Inflamatórios/farmacologia
Modelos Animais de Doenças
Simulação de Acoplamento Molecular
Monoterpenos/administração & dosagem
Monoterpenos/química
Monoterpenos/farmacologia
Dor/etiologia
Peróxidos/administração & dosagem
Peróxidos/química
Peróxidos/farmacologia
Extratos Vegetais/química
Extratos Vegetais/farmacologia
Folhas de Planta/química
Ratos
Ratos Wistar
Líquido Sinovial/efeitos dos fármacos
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Analgesics); 0 (Anti-Inflammatory Agents); 0 (Monoterpenes); 0 (Peroxides); 0 (Plant Extracts); 0 (Receptors, N-Methyl-D-Aspartate); 1718D0GEVJ (ascaridole)
[Em] Mês de entrada:1606
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151103
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0141886


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[PMID]:26001043
[Au] Autor:Song K; Zhang J; Zhang P; Wang HQ; Liu C; Li BM; Kang J; Chen RY
[Ad] Endereço:a State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College , Beijing 100050 , China.
[Ti] Título:Five new bioactive compounds from Chenopodium ambrosioides.
[So] Source:J Asian Nat Prod Res;17(5):482-90, 2015 May.
[Is] ISSN:1477-2213
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Five new bioactive compounds, chenopodiumamines A-D (1-4) and chenopodiumoside A (5), were isolated from the ethanol extract of Chenopodium ambrosioides. The structures of these compounds were elucidated by various spectroscopic means (UV, IR, HR-ESI-MS, 1D and 2D NMR). Compounds 1-3 had moderate antioxidant and anti-inflammatory activities.
[Mh] Termos MeSH primário: Anti-Inflamatórios/isolamento & purificação
Anti-Inflamatórios/farmacologia
Antioxidantes/isolamento & purificação
Antioxidantes/farmacologia
Chenopodium ambrosioides/química
Glicosídeos/isolamento & purificação
Glicosídeos/farmacologia
[Mh] Termos MeSH secundário: Anti-Inflamatórios/química
Antioxidantes/química
Glicosídeos/química
Estrutura Molecular
Ressonância Magnética Nuclear Biomolecular
Extratos Vegetais/química
Folhas de Planta/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Antioxidants); 0 (Glycosides); 0 (Plant Extracts); 0 (chenopodiumoside A)
[Em] Mês de entrada:1510
[Cu] Atualização por classe:150713
[Lr] Data última revisão:
150713
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150523
[St] Status:MEDLINE
[do] DOI:10.1080/10286020.2015.1042872


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[PMID]:25900777
[Au] Autor:Hu X; Chu Y; Ma G; Li W; Wang X; Mo H; Yin Q; Guo J; Ma X; Zhou S
[Ad] Endereço:Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, Key Laboratory of Analytical Science and Technology of Hebei Province, College of Chemistry and Environmental Science, Hebei University, Baoding, 071002, China.
[Ti] Título:Simultaneous determination of ascaridole, p-cymene and α-terpinene in rat plasma after oral administration of Chenopodium ambrosioides L. by GC-MS.
[So] Source:Biomed Chromatogr;29(11):1682-6, 2015 Nov.
[Is] ISSN:1099-0801
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A sensitive and reliable GC-MS method was developed and validated for the simultaneous determination of ascaridole, p-cymene and α-terpinene in rat plasma using naphthalene as internal standard. The plasma samples were extracted with ethyl acetate. Chromatographic separation was carried out on a HP-5MS capillary analytical column (30 m × 0.25 mm, 0.25 µm) and detection was performed on a quadrupole mass spectrometer detector operated under selected ion monitoring mode. The method showed excellent linearity over the investigated concentration range (r > 0.99) with the limit of quantitation down to 50, 10 and 5 ng/mL for ascaridole, p-cymene and α-terpinene, respectively. The intra-day and inter-day precisions (RSD) were <11.3%, and the accuracy was between 90.7 and 113.8%. The method was successfully applied to investigate the pharmacokinetics of Chenopodium ambrosioides L. following oral administration to rats.
[Mh] Termos MeSH primário: Chenopodium ambrosioides/química
Cromatografia Gasosa-Espectrometria de Massas/métodos
Monoterpenos/sangue
Peróxidos/sangue
[Mh] Termos MeSH secundário: Administração Oral
Animais
Área Sob a Curva
Meia-Vida
Limite de Detecção
Masculino
Monoterpenos/farmacocinética
Peróxidos/farmacocinética
Ratos
Ratos Wistar
Padrões de Referência
Reprodutibilidade dos Testes
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; VALIDATION STUDIES
[Nm] Nome de substância:
0 (Monoterpenes); 0 (Peroxides); 1718D0GEVJ (ascaridole); 1G1C8T1N7Q (4-cymene); 4YGF4PQP49 (gamma-terpinene)
[Em] Mês de entrada:1606
[Cu] Atualização por classe:151012
[Lr] Data última revisão:
151012
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150423
[St] Status:MEDLINE
[do] DOI:10.1002/bmc.3479


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[PMID]:25892867
[Au] Autor:Ye H; Liu Y; Li N; Yu J; Cheng H; Li J; Zhang XZ
[Ad] Endereço:Hui Ye, Ning Li, Jing Yu, Xue-Zhi Zhang, Department of Integrated Traditional Chinese Medicine, Peking University First Hospital, Beijing 100034, China.
[Ti] Título:Anti-Helicobacter pylori activities of Chenopodium ambrosioides L. in vitro and in vivo.
[So] Source:World J Gastroenterol;21(14):4178-83, 2015 Apr 14.
[Is] ISSN:2219-2840
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:AIM: To investigate the bactericidal effects of Chenopodium ambrosioides L. (CAL) against Helicobacter pylori (H. pylori) both in vitro and in vivo. METHODS: For in vitro experiments, the inhibitory activity of CAL was tested using an agar dilution method; H. pylori strain NCTC11637 was incubated on Columbia blood agar plates containing serial concentrations of CAL. The minimal inhibitory concentration (MIC) was determined by the absence of H. pylori colonies on the agar plate. Time-kill curves were used to evaluate bactericidal activity; the average number of colonies was calculated at 0, 2, 8 and 24 h after liquid incubation with concentrations of CAL at 0.5, 1, and 2 × MIC. For in vivo experiments, H. pylori-infected mice were randomly divided into CAL, triple therapy (lansoprazole, metronidazole, and clarithromycin), blank control, or H. pylori control groups. The eradication ratios were determined by positive findings from rapid urease tests (RUTs) and by histopathology. RESULTS: In vitro, the MIC of CAL against H. pylori was 16 mg/L. The time-kill curves showed a stable and persistent decreasing tendency with increasing CAL concentration, and the intensity of the bactericidal effect was proportional to dose; the 1 and 2 × MIC completely inhibited the growth of H. pylori at 24 h. In vivo, the eradication ratios in the CAL group were 60% (6/10) by RUT and 50% (5/10) by histopathology. Ratios in the triple therapy group were both 70% (7/10), and there was no difference between the CAL and triple therapy groups. Histopathologic evaluation revealed massive bacterial colonization on the surface of gastric mucosa and slight infiltration of mononuclear cells after inoculation with H. pylori, but no obvious inflammation or other pathologic changes in gastric mucosa of mice from CAL and triple therapy groups. CONCLUSION: CAL demonstrates effective bactericidal activity against H. pylori both in vitro and in vivo.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Chenopodium ambrosioides
Mucosa Gástrica/efeitos dos fármacos
Gastrite/tratamento farmacológico
Infecções por Helicobacter/tratamento farmacológico
Helicobacter pylori/efeitos dos fármacos
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Animais
Testes Respiratórios
Modelos Animais de Doenças
Quimioterapia Combinada
Mucosa Gástrica/microbiologia
Mucosa Gástrica/patologia
Gastrite/microbiologia
Gastrite/patologia
Infecções por Helicobacter/microbiologia
Infecções por Helicobacter/patologia
Helicobacter pylori/crescimento & desenvolvimento
Masculino
Camundongos
Testes de Sensibilidade Microbiana
Fitoterapia
Plantas Medicinais
Inibidores da Bomba de Prótons/farmacologia
Fatores de Tempo
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Plant Extracts); 0 (Proton Pump Inhibitors)
[Em] Mês de entrada:1601
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150421
[St] Status:MEDLINE
[do] DOI:10.3748/wjg.v21.i14.4178


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[PMID]:25697866
[Au] Autor:Pastor J; García M; Steinbauer S; Setzer WN; Scull R; Gille L; Monzote L
[Ad] Endereço:Parasitology Department, Institute of Tropical Medicine "Pedro Kouri", Havana, Cuba.
[Ti] Título:Combinations of ascaridole, carvacrol, and caryophyllene oxide against Leishmania.
[So] Source:Acta Trop;145:31-8, 2015 May.
[Is] ISSN:1873-6254
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:To date there are no vaccines against Leishmania and chemotherapy remains the mainstay for the control of leishmaniasis. The drugs currently used for leishmaniasis therapy are significantly toxic, expensive, and result in a growing frequency of refractory infections. In this study, we evaluated the effect of combinations of the main components of essential oil from Chenopodium ambrosioides (ascaridole, carvacrol, and caryophyllene oxide) against Leishmaniaamazonensis. Anti-leishmanial effects of combinations of pure compounds were evaluated in vitro and the fractional inhibitory concentration (FIC) indices were calculated. BALB/c mice infected with L. amazonensis were treated with different concentrations of ascaridole-carvacrol combinations by intralesional doses every 4 days. Disease progression and parasite burden in infected tissues were determined. In vitro experiments showed a synergistic effect of the combination of ascaridole-carvacrol against promastigotes of Leishmania with a FIC index of 0.171, while indifferent activities were observed for ascaridole-caryophyllene oxide (FIC index=3.613) and carvacrol-caryophyllene oxide (FIC index=2.356) combinations. The fixed ratio method showed that a 1:4 ascaridole-carvacrol ratio produced a better anti-protozoal activity on promastigotes, lower cytotoxicity, and synergistic activity on intracellular amastigotes (FIC index=0.416). Significant differences (p<0.05) in lesion size and parasite burden were demonstrated in BALB/c mice experimentally infected and treated with the ascaridole-carvacrol combinations compared with control animals. Carvacrol showed significant higher anti-radical activity in the DPPH assay compared with caryophyllene oxide. Electron spin resonance spectroscopy in combination with spin trapping suggested the presence of carbon-centered radicals after activation of ascaridole by Fe(2+). The intensity of the signals is preferably decreased upon addition of carvacrol. The ascaridole-carvacrol combination could represent a future alternative to monotherapeutic anti-leishmanial agents.
[Mh] Termos MeSH primário: Antiprotozoários/administração & dosagem
Leishmania/efeitos dos fármacos
Leishmaniose Cutânea/tratamento farmacológico
Monoterpenos/administração & dosagem
Peróxidos/administração & dosagem
Sesquiterpenos/administração & dosagem
[Mh] Termos MeSH secundário: Animais
Antiprotozoários/farmacologia
Chenopodium ambrosioides/química
Combinação de Medicamentos
Cálculos da Dosagem de Medicamento
Camundongos
Camundongos Endogâmicos BALB C
Óleos Voláteis/farmacologia
Fitoterapia
Óleos Vegetais/administração & dosagem
Óleos Vegetais/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antiprotozoal Agents); 0 (Drug Combinations); 0 (Monoterpenes); 0 (Oils, Volatile); 0 (Peroxides); 0 (Plant Oils); 0 (Sesquiterpenes); 1718D0GEVJ (ascaridole); 9B1J4V995Q (carvacrol); S2XU9K448U (caryophyllene oxide)
[Em] Mês de entrada:1510
[Cu] Atualização por classe:150323
[Lr] Data última revisão:
150323
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150221
[St] Status:MEDLINE


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[PMID]:25495783
[Au] Autor:Harraz FM; Hammoda HM; El Ghazouly MG; Farag MA; El-Aswad AF; Bassam SM
[Ad] Endereço:a Department of Pharmacognosy , Faculty of Pharmacy, University of Alexandria , 21521 Alexandria , Egypt.
[Ti] Título:Chemical composition, antimicrobial and insecticidal activities of the essential oils of Conyza linifolia and Chenopodium ambrosioides.
[So] Source:Nat Prod Res;29(9):879-82, 2015.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Two essential oil-containing plants growing wildly in Egypt: Conyza linifolia (Willd.) Täckh. (Asteraceae) and Chenopodium ambrosioides L. (Chenopodiaceae) were subjected to essential oil analysis and biological investigation. The essential oils from both plants were prepared by hydrodistillation, and GC/MS was employed for volatiles profiling. This study is the first to perform GC/MS analysis of C. linifolia essential oil growing in Egypt. C. linifolia essential oil contained mainly sesquiterpenes, while that of C. ambrosioides was rich in monoterpenes. Ascaridole, previously identified as the major component of the latter, was found at much lower levels. In addition, the oils were investigated for their antimicrobial activity against two Gram positive and two Gram negative bacteria, and one fungus. The insecticidal activities of both oils, including mosquitocidal and pesticidal potentials, were also evaluated. The results of biological activities encourage further investigation of the two oils as antimicrobial and insecticidal agents of natural origin.
[Mh] Termos MeSH primário: Anti-Infecciosos/química
Chenopodium ambrosioides/química
Conyza/química
Inseticidas/química
Óleos Voláteis/química
Óleos Vegetais/química
[Mh] Termos MeSH secundário: Animais
Anti-Infecciosos/isolamento & purificação
Culex/efeitos dos fármacos
Egito
Cromatografia Gasosa-Espectrometria de Massas
Inseticidas/isolamento & purificação
Testes de Sensibilidade Microbiana
Monoterpenos/química
Monoterpenos/isolamento & purificação
Peróxidos/química
Peróxidos/isolamento & purificação
Sesquiterpenos/química
Sesquiterpenos/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Infective Agents); 0 (Insecticides); 0 (Monoterpenes); 0 (Oils, Volatile); 0 (Peroxides); 0 (Plant Oils); 0 (Sesquiterpenes); 1718D0GEVJ (ascaridole)
[Em] Mês de entrada:1506
[Cu] Atualização por classe:150327
[Lr] Data última revisão:
150327
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141216
[St] Status:MEDLINE
[do] DOI:10.1080/14786419.2014.988714



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