Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.198.500.250.055 [Categoria DeCS]
Referências encontradas : 9 [refinar]
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  1 / 9 MEDLINE  
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[PMID]:26196402
[Au] Autor:Bohlooli S; Bohlooli S; Aslanian R; Nouri F; Teimourzadeh A
[Ad] Endereço:Department of Pharmacology and Toxicology, School of Pharmacy, Ardabil University of Medical Sciences, Ardabil, Iran; Drug and Advanced Sciences Research Center, School of Pharmacy, Ardabil University of Medical Sciences, Ardabil, Iran. Electronic address: shahab.bohlooli@arums.ac.ir.
[Ti] Título:Aqueous extract of Agrostemma githago seed inhibits caspase-3 and induces cell-cycle arrest at G1 phase in AGS cell line.
[So] Source:J Ethnopharmacol;175:295-300, 2015 Dec 04.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:ETHNOPHARMACOLOGICAL RELEVANCE: A weed plant belonging to the Caryophyllaceae family, Agrostemma githago is used in folk medicine to treat cancers and warts. AIM OF THE STUDY: The aim of this study was to evaluate the cytotoxic effect of the aqueous extract of A. githago seed on gastric cancer cell line (AGS) and to investigate the mechanism of apoptosis induction in these cells. MATERIALS AND METHODS: Seeds of A. githago were collected from the suburban area of Ardabil Province, northwest Iran. After preparing the aqueous extract, dry matter was harvested with the lyophilizing technique. The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay was used to assess the cytotoxicity. Apoptotic cells were detected by staining with ethidium bromide/acridine orange (EB/AO). Diamidino-2-phenylindole (DAPI) staining was used for cell-cycle analysis with a flow cytometer. The annexin V binding level, caspase-3 activity, and B-cell lymphoma-2 (Bcl-2) level were also measured to confirm apoptotic cell death. RESULTS: After the aqueous extract of A. githago seed was incubated for 24, 48, and 72 h, inhibited cell growth was observed with IC50 values of 13.51 ± 0.7, 4.37 ± 1.01, and 2.42 ± 0.8 µg/ml, respectively. The EB/AO staining method demonstrated that the extract exerts its cytotoxic effect mainly via apoptosis, in accordance with the annexin V, blc-2, and caspase-3 results. The extract showed a concentration-dependent increase in annexin V binding to externally exposed phosphatidylserine as well as caspase-3 activity. The bcl-2 protein level showed a proportionate decrease with the increase in extract concentration. The cell-cycle analysis revealed that the extract can arrest cells at the G1 checkpoint. CONCLUSION: The findings of this study revealed the cytotoxic effect of the aqueous extract of A. githago seed on gastric cancer cells (AGS) mainly via apoptosis and the cell-cycle arrest at the G1 checkpoint. Therefore, the extract can be potentially used in gastric cancer therapy in vitro.
[Mh] Termos MeSH primário: Agrostemma
Antineoplásicos/farmacologia
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Apoptose/efeitos dos fármacos
Caspase 3/metabolismo
Pontos de Checagem do Ciclo Celular/efeitos dos fármacos
Linhagem Celular Tumoral
Sobrevivência Celular/efeitos dos fármacos
Fase G1/efeitos dos fármacos
Seres Humanos
Sementes
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Plant Extracts); EC 3.4.22.- (Caspase 3)
[Em] Mês de entrada:1609
[Cu] Atualização por classe:151215
[Lr] Data última revisão:
151215
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150722
[St] Status:MEDLINE


  2 / 9 MEDLINE  
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[PMID]:23294449
[Au] Autor:Goodrich SH; Beans CM; Roach DA
[Ad] Endereço:Department of Biology, University of Virginia, Charlottesville, VA 22901, USA. stephgoodrich@gmail.com
[Ti] Título:Environmental conditions during early life determine the consequences of inbreeding in Agrostemma githago (Caryophyllaceae).
[So] Source:J Evol Biol;26(3):499-508, 2013 Mar.
[Is] ISSN:1420-9101
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:In an inbred population, selection may reduce the frequency of deleterious recessive alleles through a process known as purging. Empirical studies suggest, however, that the efficacy of purging in natural populations is highly variable. This variation may be due, in part, to variation in the expression of inbreeding depression available for selection to act on. This experiment investigates the roles of life stage and early-life environment in determining the expression of inbreeding depression in Agrostemma githago. Four population-level crosses ('self', 'within', 'near' and 'far') were conducted on 20 maternal plants from a focal population. Siblings were planted into one of three early environmental treatments with varying stress levels. Within the focal population, evidence for purging of deleterious recessive alleles, as well as for variation in the expression of inbreeding depression across the life cycle was examined. In addition, the effect of early environment on the expression of inbreeding depression and the interaction with cross-type was measured. We find that deleterious recessive alleles have not been effectively purged from our focal population, the expression of inbreeding depression decreases over the course of the life cycle, and a stressful early environment reduces the variance in inbreeding depression expressed later in life, but does not consistently influence the relative fitness of inbred versus outcrossed individuals.
[Mh] Termos MeSH primário: Agrostemma/fisiologia
Meio Ambiente
Endogamia
[Mh] Termos MeSH secundário: Agrostemma/genética
Alelos
Cruzamentos Genéticos
Flores/genética
Flores/fisiologia
Aptidão Genética
Sementes/genética
Sementes/fisiologia
Seleção Genética
Autofertilização
Estresse Fisiológico
Fatores de Tempo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Em] Mês de entrada:1308
[Cu] Atualização por classe:130214
[Lr] Data última revisão:
130214
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130109
[St] Status:MEDLINE
[do] DOI:10.1111/jeb.12065


  3 / 9 MEDLINE  
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[PMID]:20056261
[Au] Autor:Koz O; Bedir E; Masullo M; Alankus-Caliskan O; Piacente S
[Ad] Endereço:Ege University, Faculty of Science, Department of Chemistry, Bornova, Izmir, Turkey.
[Ti] Título:Triterpene glycosides from Agrostemma gracilis.
[So] Source:Phytochemistry;71(5-6):663-8, 2010 Apr.
[Is] ISSN:1873-3700
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Four triterpene saponins, agrostemmosides A-D were isolated from the methanol extract of Agrostemma gracilis. The structures of the compounds were determined as 3-O-beta-D-xylopyranosyloleanolic acid 28-O-beta-D-glucopyranosyl-(1-->2)-[beta-D-xylopyranosyl-(1-->6)]-beta-D-glucopyranosyl-(1-->6)-beta-D-glucopyranosyl ester, 3-O-alpha-L-rhamnopyranosyl-(1-->2)-beta-D-xylopyranosyloleanolic acid 28-O-beta-D-glucopyranosyl-(1-->2)-[beta-D-xylopyranosyl-(1-->6)]-beta-D-glucopyranosyl-(1-->6)-beta-D-glucopyranosyl ester, 3-O-beta-D-xylopyranosylechinocystic acid 28-O-beta-D-glucopyranosyl-(1-->2)-beta-D-glucopyranosyl-(1-->6)-beta-D-glucopyranosyl ester, 3-O-beta-D-xylopyranosylechinocystic acid 28-O-beta-D-glucopyranosyl-(1-->2)-[beta-D-xylopyranosyl-(1-->6)]-beta-D-glucopyranosyl-(1-->6)-beta-D-glucopyranosyl ester by a combination of one- and two-dimensional NMR techniques, and mass spectrometry. To the best of our knowledge this is the first phytochemical report on A. gracilis, and echinocystic acid saponins were encountered for the first time in Caryophyllaceae family.
[Mh] Termos MeSH primário: Agrostemma/química
Glicosídeos/isolamento & purificação
Extratos Vegetais/química
Triterpenos/isolamento & purificação
[Mh] Termos MeSH secundário: Glicosídeos/química
Estrutura Molecular
Ácido Oleanólico/análogos & derivados
Ácido Oleanólico/química
Ácido Oleanólico/isolamento & purificação
Saponinas/química
Saponinas/isolamento & purificação
Triterpenos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Glycosides); 0 (Plant Extracts); 0 (Saponins); 0 (Triterpenes); 0 (agrostemmoside A); 0 (agrostemmoside B); 0 (agrostemmoside C); 0 (agrostemmoside D); 6SMK8R7TGJ (Oleanolic Acid); L4DUW10YOF (echinocystic acid)
[Em] Mês de entrada:1010
[Cu] Atualização por classe:151119
[Lr] Data última revisão:
151119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:100109
[St] Status:MEDLINE
[do] DOI:10.1016/j.phytochem.2009.12.001


  4 / 9 MEDLINE  
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[PMID]:18412343
[Au] Autor:Mobian P; Nicolas C; Francotte E; Bürgi T; Lacour J
[Ad] Endereço:Department of Organic Chemistry, University of Geneva, 30 Quai Ernest-Ansermet, CH-1211 Geneva 4, Switzerland.
[Ti] Título:Synthesis, resolution, and VCD analysis of an enantiopure diazaoxatricornan derivative.
[So] Source:J Am Chem Soc;130(20):6507-14, 2008 May 21.
[Is] ISSN:1520-5126
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Using simple organic synthetic transformations, a novel diazaoxatricornan derivative, the 12 c-methyl-12-phenyl-8-propyl-12,12 c-dihydro-8 H-4-oxa-8,12-diazadibenzo[ cd, mn]pyrene ( 6a), was prepared. This novel chiral cup-shaped molecule was isolated in racemic form and in excellent yield after the addition of methyl lithium to the BF 4 salt of a novel unsymmetrical diazaoxatriangulenium cation. Compound 6a was found to be stable under classical laboratory conditions-something not obvious considering the extreme stability of the carbenium ion precursor, the electron-rich nature of the core, and the strain induced by the pyramidalization of the central carbon. The enantiomers were readily separated by chiral stationary phase chromatography, and the absolute configuration of (-)-( S)- 6a was determined by a comparison of the experimental and theoretical vibrational circular dichroism (VCD) spectra. This isolation of (-)-( S)- 6a and (+)-( R)- 6a constitutes thus the first report of a nonracemic closed-capped chiral bowl molecule for which the chirality is due to the intrinsic dissymmetry of the central core of the structure only.
[Mh] Termos MeSH primário: Compostos Aza/síntese química
Benzopirenos/síntese química
[Mh] Termos MeSH secundário: Agrostemma
Compostos Aza/química
Benzopirenos/química
Dicroísmo Circular
Modelos Moleculares
Conformação Molecular
Espectrofotometria Infravermelho
Estereoisomerismo
Termodinâmica
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Aza Compounds); 0 (Benzopyrenes)
[Em] Mês de entrada:0807
[Cu] Atualização por classe:080515
[Lr] Data última revisão:
080515
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:080417
[St] Status:MEDLINE
[do] DOI:10.1021/ja800262j


  5 / 9 MEDLINE  
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[PMID]:16713156
[Au] Autor:Avci G; Kupeli E; Eryavuz A; Yesilada E; Kucukkurt I
[Ad] Endereço:Department of Biochemistry, Faculty of Veterinary Medicine, Afyon Kocatepe University, Afyon, Turkey.
[Ti] Título:Antihypercholesterolaemic and antioxidant activity assessment of some plants used as remedy in Turkish folk medicine.
[So] Source:J Ethnopharmacol;107(3):418-23, 2006 Oct 11.
[Is] ISSN:0378-8741
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:Ethanolic and aqueous extracts from five plant species used in Turkish traditional medicine were evaluated for in vivo hypercholesterolaemic and antioxidant activities: Agrostemma githago L., Potentilla reptans L., Thymbra spicata var. spicata L., Urtica dioica L. and Viscum album var. album L. We assayed the effects of the administration of plant extracts on serum total cholesterol, triglyceride, HDL-C, LDL-C, glucose, AST and ALT concentrations in mice fed with cholesterol-rich diet. In addition, plasma TAA, MDA and NO(x) levels in the same animals were assayed. All the aqueous plant extracts did not affect the serum cholesterol concentration. However, the ethanolic extracts of Agrostemma githago, Thymbra spicata and Viscum album decreased the serum cholesterol concentration in the mice fed with high-cholesterol diet without inducing any gastric damage. The ethanolic extracts of Thymbra spicata, Viscum album, Potentilla reptans and Urtica dioica and the aqueous extract of Agrostemma githago increased the serum HDL concentration, whereas the ethanolic extracts of Agrostemma githago, Thymbra spicata, Viscum album and Urtica dioica decreased the serum LDL-C concentration. Thymbra spicata and Viscum album were observed to decrease the serum triglyceride concentration. Among the plant extracts studied, the ethanolic extracts of Thymbra spicata significantly decreased the MDA level in mice. The ethanolic extract of Potentilla reptans increased in NO(x). None of these plants showed statistically prominent activity on plasma TAA. Results of the present study indicated that the ethanolic extracts of Agrostemma githago, Thymbra spicata and Viscum album showed potent hypocholesterolaemic activity in the mice fed with a diet containing high-cholesterol.
[Mh] Termos MeSH primário: Agrostemma
Anticolesterolemiantes/farmacologia
Antioxidantes/farmacologia
Potentilla
Thymus (Planta)
Urtica dioica
Viscum album
[Mh] Termos MeSH secundário: Alanina Transaminase/sangue
Animais
Anticolesterolemiantes/uso terapêutico
Antioxidantes/uso terapêutico
Aspartato Aminotransferases/sangue
Glicemia/efeitos dos fármacos
Colesterol na Dieta/administração & dosagem
Hipercolesterolemia/sangue
Hipercolesterolemia/prevenção & controle
Peroxidação de Lipídeos/efeitos dos fármacos
Lipídeos/sangue
Masculino
Medicina Tradicional
Camundongos
Óxido Nítrico/sangue
Extratos Vegetais/farmacologia
Turquia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anticholesteremic Agents); 0 (Antioxidants); 0 (Blood Glucose); 0 (Cholesterol, Dietary); 0 (Lipids); 0 (Plant Extracts); 31C4KY9ESH (Nitric Oxide); EC 2.6.1.1 (Aspartate Aminotransferases); EC 2.6.1.2 (Alanine Transaminase)
[Em] Mês de entrada:0701
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:060523
[St] Status:MEDLINE


  6 / 9 MEDLINE  
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[PMID]:16387336
[Au] Autor:Hebestreit P; Weng A; Bachran C; Fuchs H; Melzig MF
[Ad] Endereço:Institute of Pharmacy, Free University Berlin, Königin-Luise-Str. 2+4, D-14195 Berlin, Germany.
[Ti] Título:Enhancement of cytotoxicity of lectins by Saponinum album.
[So] Source:Toxicon;47(3):330-5, 2006 Mar.
[Is] ISSN:0041-0101
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Saponinum album, a mixture of saponins with an aldehyde function bound at C4 from Gypsophila species, increased the cytotoxicity of lectins like agrostin and saporin by enhancing its penetration through the cell membrane. The effect was attenuated by latrunculin, an inhibitor of endocytosis, and by bafilomycin, an inhibitor of transport from early to late endosomes and lysosomes. In contrast, the effect was not influenced by brefeldin A that causes dissolution of the Golgi stacks and by the addition of different monosaccharides. The toxicity of other peptidic toxins was only slightly enhanced by the saponins indicating a specific interaction between lectins and saponins present in Caryophyllaceae.
[Mh] Termos MeSH primário: Agrostemma
Caryophyllaceae
Sobrevivência Celular/efeitos dos fármacos
Lectinas/toxicidade
Saponinas/toxicidade
[Mh] Termos MeSH secundário: Animais
Linhagem Celular/efeitos dos fármacos
Sinergismo Farmacológico
Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos
Complexo de Golgi/efeitos dos fármacos
Lectinas/química
Saponinas/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Lectins); 0 (Saponins)
[Em] Mês de entrada:0605
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:060103
[St] Status:MEDLINE


  7 / 9 MEDLINE  
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[PMID]:16392757
[Au] Autor:Ragulin VV; Kuznetsov VV; Kuznetsov VV
[Ad] Endereço:Timiryazev Institute of Plant Physiology, Russian Academy of Sciences, Botanicheskaya ul. 35, 127276 Moscow.
[Ti] Título:Differential regulation of nitrate reductase gene expression in corn cockle embryos by cytokinin and nitrate.
[So] Source:Dokl Biochem Biophys;404:360-2, 2005 Sep-Oct.
[Is] ISSN:1607-6729
[Cp] País de publicação:Russia (Federation)
[La] Idioma:eng
[Mh] Termos MeSH primário: Agrostemma/efeitos dos fármacos
Citocininas/farmacologia
Regulação da Expressão Gênica de Plantas/efeitos dos fármacos
Nitrato Redutases/metabolismo
Nitratos/farmacologia
Sementes/efeitos dos fármacos
[Mh] Termos MeSH secundário: Agrostemma/embriologia
Agrostemma/enzimologia
Nitrato Redutases/genética
Reguladores de Crescimento de Planta/farmacologia
RNA Mensageiro/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Cytokinins); 0 (Nitrates); 0 (Plant Growth Regulators); 0 (RNA, Messenger); EC 1.7.- (Nitrate Reductases)
[Em] Mês de entrada:0603
[Cu] Atualização por classe:171019
[Lr] Data última revisão:
171019
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:060106
[St] Status:MEDLINE


  8 / 9 MEDLINE  
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[PMID]:15473635
[Au] Autor:Schmidt B; Patti H; Hommes G; Schuphan I
[Ad] Endereço:Department of Biology V (Ecology, Ecotoxicology, Ecochemistry), RWTH Aachen University, Aachen, Germany. burkhard.schmidt@post.rwth-aachen.de
[Ti] Título:Metabolism of the nonylphenol isomer [ring-U-14C]-4-(3',5'-dimethyl-3'-heptyl)-phenol by cell suspension cultures of Agrostemma githago and soybean.
[So] Source:J Environ Sci Health B;39(4):533-49, 2004 May.
[Is] ISSN:0360-1234
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The biotransformation of the nonylphenol isomer [ring-U-14C]-4-(3',5'-dimethyl-3'-heptyl)-phenol (4-353-NP, consisting of two diastereomers) was studied in soybean and Agrostemma githago cell suspension cultures. With the A. githago cells, a batch two-liquid-phase system (medium/n-hexadecane 200:1, v/v) was used, in order to produce higher concentrations and amounts of 4-353-NP metabolites for their identification; 4-353-NP was applied via the n-hexadecane phase. Initial concentrations of [14C]-4-353-NP were 1 mg L(-1) (soybean), and 5 and 10 mg L(-1) (A. githago). After 2 (soybean) and 7 days (A. githago) of incubation, the applied 4-353-NP was transformed almost completely by both plant species to four types of products: glycosides of parent 4-353-NP, glycosides of primary 4-353-NP metabolites, nonextractable residues and unknown, possibly polymeric materials detected in the media. The latter two products emerged especially in soybean cultures. Portions of primary metabolites amounted to 19-22% (soybean) and 21-42% of applied 14C (A. githago). After liberation from their glycosides, the primary 4-353-NP metabolites formed by A. githago were isolated by HPLC and examined by GC-EIMS as trimethylsilyl derivatives. In the chromatograms, eight peaks were detected which due to their mass spectra, could be traced back to 4-353-NP. Seven of the compounds were side-chain monohydroxylated 4-353-NP metabolites, while the remaining was a (side-chain) carboxylic acid derivative. Unequivocal identification of the sites of hydroxylation/oxidation of all transformation products was not possible. The main primary metabolites produced by A. githago were supposed to be four diastereomers of 6'-hydroxy-4-353-NP (about 80% of all products identified). It was concluded that plants contribute to the environmental degradation of the xenoestrogen nonylphenol; the toxicological properties of side-chain hydroxylated nonylphenols remain to be examined.
[Mh] Termos MeSH primário: Agrostemma/fisiologia
Fenóis/metabolismo
Feijão de Soja/fisiologia
[Mh] Termos MeSH secundário: Técnicas de Cultura de Células
Fenóis/química
Estereoisomerismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Phenols); 79F6A2ILP5 (nonylphenol)
[Em] Mês de entrada:0412
[Cu] Atualização por classe:161124
[Lr] Data última revisão:
161124
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:041012
[St] Status:MEDLINE


  9 / 9 MEDLINE  
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[PMID]:14648395
[Au] Autor:Hebestreit P; Melzig MF
[Ad] Endereço:Institut für Pharmazie, Freie Universität Berlin, Berlin, Germany.
[Ti] Título:Cytotoxic activity of the seeds from Agrostemma githago var. githago.
[So] Source:Planta Med;69(10):921-5, 2003 Oct.
[Is] ISSN:0032-0943
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:In our investigations aqueous extracts of the seeds from Agrostemma githago L. proved to be remarkably more cytotoxic in comparison with isolated agrostemmasaponins in equal concentrations. A combination of agrostemmasaponin 1 with a formyl function attached to triterpene position 4 together with agrostin, a ribosome-inactivating protein (RIP type 1; M (r): 27 kDa) which we isolated from the seed material, resulted in a markedly increased cytotoxicity. In analogy to the well-known lectin-like mechanism of action which can be inhibited by different monosaccharides, we tested seven different sugars known for their affinity to prevent cell recognition and thereby detoxify lectins. None of the tested monosaccharides diminished toxicity values significantly. This suggests that agrostin, combined with agrostemmasaponin 1, has a different mode of action to penetrate through the cell membrane than lectins. On the basis of these facts we concluded that both compounds work as a functional unity showing a mechanism of "cooperative toxicity".
[Mh] Termos MeSH primário: Agrostemma
Antineoplásicos Fitogênicos/farmacologia
Fitoterapia
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Antineoplásicos Fitogênicos/administração & dosagem
Antineoplásicos Fitogênicos/uso terapêutico
Linhagem Celular Tumoral/efeitos dos fármacos
Seres Humanos
Concentração Inibidora 50
Extratos Vegetais/administração & dosagem
Extratos Vegetais/uso terapêutico
Sementes
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Plant Extracts)
[Em] Mês de entrada:0402
[Cu] Atualização por classe:061115
[Lr] Data última revisão:
061115
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:031204
[St] Status:MEDLINE



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