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[PMID]: 28780442 [Au] Autor: Volkov AG; Xu KG; Kolobov VI [Ad] Endereço: Department of Chemistry, Oakwood University, Huntsville, AL 35896, USA. Electronic address: gvolkov@oakwood.edu. [Ti] Título: Cold plasma interactions with plants: Morphing and movements of Venus flytrap and Mimosa pudica induced by argon plasma jet. [So] Source: Bioelectrochemistry;118:100-105, 2017 Dec. [Is] ISSN: 1878-562X [Cp] País de publicação: Netherlands [La] Idioma: eng [Ab] Resumo: Low temperature (cold) plasma finds an increasing number of applications in biology, medicine and agriculture. In this paper, we report a new effect of plasma induced morphing and movements of Venus flytrap and Mimosa pudica. We have experimentally observed plasma activation of sensitive plant movements and morphing structures in these plants similar to stimulation of their mechanosensors in vivo. Application of an atmospheric pressure argon plasma jet to the inside or outside of a lobe, midrib, or cilia in Dionaea muscipula Ellis induces trap closing. Treatment of Mimosa pudica by plasma induces movements of pinnules and petioles similar to the effects of mechanical stimulation. We have conducted control experiments and simulations to illustrate that gas flow and UV radiation associated with plasma are not the primary reasons for the observed effects. Reactive oxygen and nitrogen species (RONS) produced by cold plasma in atmospheric air appear to be the primary reason of plasma-induced activation of phytoactuators in plants. Some of these RONS are known to be signaling molecules, which control plants' developmental processes. Understanding these mechanisms could promote plasma-based technology for plant developmental control and future use for plant protection from pathogens. Our work offers new insight into mechanisms which trigger plant morphing and movement. [Mh] Termos MeSH primário: Argônio/química Argônio/farmacologia Temperatura Baixa Droseraceae/efeitos dos fármacos Mimosa/efeitos dos fármacos Movimento/efeitos dos fármacos Gases em Plasma/farmacologia [Mh] Termos MeSH secundário: Droseraceae/anatomia & histologia Droseraceae/fisiologia Mimosa/anatomia & histologia Mimosa/fisiologia [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Plasma Gases); 67XQY1V3KH (Argon) [Em] Mês de entrada: 1709 [Cu] Atualização por classe: 170927 [Lr] Data última revisão: 170927 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170807 [St] Status: MEDLINE

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[PMID]: 28681555 [Au] Autor: Parker ML; Ramaswamy R; van Gordon K; Powell CJ; Bosch J; Boulanger MJ [Ad] Endereço: Biochemistry & Microbiology, University of Victoria, Victoria, British Columbia, V8W 3P6, Canada. [Ti] Título: The structure of Plasmodium falciparum 3D7_0606800 reveals a bi-lobed architecture that supports re-annotation as a Venus Flytrap protein. [So] Source: Protein Sci;26(9):1878-1885, 2017 Sep. [Is] ISSN: 1469-896X [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Plasmodium falciparum, the causative agent of malaria, employs a diverse array of surface displayed proteins to promote dissemination and establish infection in the human host. Of these, Pf3D7_0606800 is highly immunogenic and has been designated a potential top 10 candidate for inclusion in a multicomponent malarial vaccine. The role of Pf3D7_0606800 in parasite biology, however, is unknown and its characterization has been complicated by a lack of sequence identity with proteins of known structure or function. Towards elucidating Pf3D7_0606800 function, we determined its structure to a resolution of 2.35 Å using selenium single wavelength anomalous dispersion. A bi-lobed architecture displays the core structural hallmarks of Venus Flytrap (VFT) proteins prompting us to re-annotate Pf3D7_0606800 as PfVFT1. Structural analysis further revealed an extended inter-lobe groove that, when interrogated by molecular docking, appears well suited to bind peptide-based ligands. Collectively, our structural characterization of the highly antigenic P. falciparum surface protein PfVFT1 provides intriguing functional insight and establishes a structural template that could prove valuable for malaria vaccine engineering studies. [Mh] Termos MeSH primário: Plasmodium falciparum/química Proteínas de Protozoários/química [Mh] Termos MeSH secundário: Cristalografia por Raios X Droseraceae/química Simulação de Acoplamento Molecular Proteínas de Plantas/química Plasmodium falciparum/genética Conformação Proteica [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Plant Proteins); 0 (Protozoan Proteins) [Em] Mês de entrada: 1709 [Cu] Atualização por classe: 170925 [Lr] Data última revisão: 170925 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170707 [St] Status: MEDLINE [do] DOI: 10.1002/pro.3218

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[PMID]: 28359198 [Au] Autor: Liu Y; Cai Y; He C; Chen M; Li H [Ad] Endereço: * Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, P.R. China. [Ti] Título: Anticancer Properties and Pharmaceutical Applications of Plumbagin: A Review. [So] Source: Am J Chin Med;45(3):423-441, 2017. [Is] ISSN: 0192-415X [Cp] País de publicação: Singapore [La] Idioma: eng [Ab] Resumo: It has been shown that plumbagin, a bioactive naphthoquinone isolated from three major plant families viz. Plumbaginaceae, Ebenceae and Droseraceae, definitively exhibits anticancer potential in diverse cancer cells both in vitro and in vivo. Plumbagin shows antineoplastic effects via multi-channel molecular mechanisms, including the induction of apoptosis and autophagy, the disruption of the cell cycle, the inhibition of invasion and metastasis, and anti-angiogenesis. Plumbagin inhibits the growth of cancer cells mainly through the modulation of the signals of PI3K/Akt/mTOR, AMPK, Ras, and so on. The pharmaceutical applications of plumbagin combined with nanocarriers to achieve better therapeutic efficiency are discussed in this review Among them, liposomes, nanoparticles, microspheres, micelles, and nisosomes are used in cancer treatment. The anticancer study of plumbagin in vivo is also summarized in this review. On the whole, we aim to review the research progress of plumbagin both in pharmacological and pharmaceutical filed, which may provide some reference for further research of plumbagin. [Mh] Termos MeSH primário: Antineoplásicos Fitogênicos Naftoquinonas/farmacologia Naftoquinonas/uso terapêutico Neoplasias/tratamento farmacológico Fitoterapia Transdução de Sinais/efeitos dos fármacos [Mh] Termos MeSH secundário: Proteínas Quinases Ativadas por AMP Animais Apoptose/efeitos dos fármacos Autofagia/efeitos dos fármacos Droseraceae/química Ebenaceae/química Genes ras Seres Humanos Técnicas In Vitro Camundongos Naftoquinonas/isolamento & purificação Neoplasias/genética Neoplasias/patologia Fosfatidilinositol 3-Quinase/metabolismo Plumbaginaceae/química Proteínas Proto-Oncogênicas c-akt/metabolismo Transdução de Sinais/genética Serina-Treonina Quinases TOR/metabolismo [Pt] Tipo de publicação: JOURNAL ARTICLE; REVIEW [Nm] Nome de substância: 0 (Antineoplastic Agents, Phytogenic); 0 (Naphthoquinones); EC 2.7.1.1 (TOR Serine-Threonine Kinases); EC 2.7.1.137 (Phosphatidylinositol 3-Kinase); EC 2.7.11.1 (Proto-Oncogene Proteins c-akt); EC 2.7.11.31 (AMP-Activated Protein Kinases); YAS4TBQ4OQ (plumbagin) [Em] Mês de entrada: 1709 [Cu] Atualização por classe: 171116 [Lr] Data última revisão: 171116 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170401 [St] Status: MEDLINE [do] DOI: 10.1142/S0192415X17500264

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[PMID]: 28179680 [Ti] Título: The long reach of the monster plant. [So] Source: Nature;542(7640):138, 2017 02 07. [Is] ISSN: 1476-4687 [Cp] País de publicação: England [La] Idioma: eng [Mh] Termos MeSH primário: Carnivoridade Droseraceae/metabolismo Literatura Moderna/história [Mh] Termos MeSH secundário: História do Século XIX Nitrogênio/metabolismo North Carolina Petunia/metabolismo Fósforo/metabolismo Solanum tuberosum/metabolismo [Pt] Tipo de publicação: EDITORIAL; HISTORICAL ARTICLE [Nm] Nome de substância: 27YLU75U4W (Phosphorus); N762921K75 (Nitrogen) [Em] Mês de entrada: 1707 [Cu] Atualização por classe: 170713 [Lr] Data última revisão: 170713 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170210 [St] Status: MEDLINE [do] DOI: 10.1038/542138b

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[PMID]: 28065921 [Au] Autor: Paniw M; Gil-Cabeza E; Ojeda F [Ti] Título: Plant carnivory beyond bogs: reliance on prey feeding in Drosophyllum lusitanicum (Drosophyllaceae) in dry Mediterranean heathland habitats. [So] Source: Ann Bot;119(6):1035-1041, 2017 Apr 01. [Is] ISSN: 1095-8290 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: Background and Aims: In a cost-benefit framework, plant carnivory is hypothesized to be an adaptation to nutrient-poor soils in sunny, wetland habitats. However, apparent exceptions to this cost-benefit model exist, although they have been rarely studied. One of these exceptions is the carnivorous subshrub Drosophyllum lusitanicum , which thrives in Mediterranean heathlands on dry sandstone soils and has relatively well-developed, xeromorphic roots. Here, the roles of leaf (carnivory) and root (soil) nutrient uptake in growth promotion of this particular species were assessed. Methods: In a greenhouse experiment, plants were fed with laboratory-reared fruit flies ( Drosophila virilis ) and received two concentrations of soil nutrients in a factorial design. Above-ground plant growth and final above- and below-ground dry biomass after 13 weeks were recorded. Nutrient uptake via roots was also evaluated, using stable nitrogen isotope analysis. Key Results: Insect feeding resulted in significantly higher growth and above- and below-ground biomass compared with soil fertilization. No additional benefits of fertilization were discernable when plants were insect-fed, indicating that roots were not efficient in nutrient absorption. Conclusions: The first evidence of strong reliance on insect prey feeding in a dry-soil carnivorous plant with well-developed roots is provided, suggesting that carnivory per se does not preclude persistence in dry habitats. Instead, the combination of carnivory and xeromorphic root features allows Drosophyllum to thrive on non-waterlogged soils. New evidence is added to recent research emphasizing the role of root systems of carnivorous plants in explaining their distribution, partly challenging the cost-benefit hypothesis. [Mh] Termos MeSH primário: Droseraceae/fisiologia Cadeia Alimentar [Mh] Termos MeSH secundário: Animais Droseraceae/crescimento & desenvolvimento Insetos Isótopos de Nitrogênio/análise Folhas de Planta/fisiologia Raízes de Plantas/fisiologia Espanha [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Nitrogen Isotopes) [Em] Mês de entrada: 1705 [Cu] Atualização por classe: 171116 [Lr] Data última revisão: 171116 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170110 [St] Status: MEDLINE [do] DOI: 10.1093/aob/mcw247

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[PMID]: 28025291 [Au] Autor: Veleba A; Smarda P; Zedek F; Horová L; Smerda J; Bures P [Ad] Endereço: Department of Botany and Zoology, Faculty of Science, Masaryk University, Kotlárská 2, Brno, CZ 61137, Czech Republic. [Ti] Título: Evolution of genome size and genomic GC content in carnivorous holokinetics (Droseraceae). [So] Source: Ann Bot;119(3):409-416, 2017 Feb. [Is] ISSN: 1095-8290 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: BACKGROUND AND AIMS: Studies in the carnivorous family Lentibulariaceae in the last years resulted in the discovery of the smallest plant genomes and an unusual pattern of genomic GC content evolution. However, scarcity of genomic data in other carnivorous clades still prevents a generalization of the observed patterns. Here the aim was to fill this gap by mapping genome evolution in the second largest carnivorous family, Droseraceae, where this evolution may be affected by chromosomal holokinetism in Drosera METHODS: The genome size and genomic GC content of 71 Droseraceae species were measured by flow cytometry. A dated phylogeny was constructed, and the evolution of both genomic parameters and their relationship to species climatic niches were tested using phylogeny-based statistics. KEY RESULTS: The 2C genome size of Droseraceae varied between 488 and 10 927 Mbp, and the GC content ranged between 37·1 and 44·7 %. The genome sizes and genomic GC content of carnivorous and holocentric species did not differ from those of their non-carnivorous and monocentric relatives. The genomic GC content positively correlated with genome size and annual temperature fluctuations. The genome size and chromosome numbers were inversely correlated in the Australian clade of Drosera CONCLUSIONS: Our results indicate that neither carnivory (nutrient scarcity) nor the holokinetism have a prominent effect on size and DNA base composition of Droseraceae genomes. However, the holokinetic drive seems to affect karyotype evolution in one of the major clades of Drosera Our survey confirmed that the evolution of GC content is tightly connected with the evolution of genome size and also with environmental conditions. [Mh] Termos MeSH primário: Evolução Biológica Droseraceae/genética Genoma de Planta/genética [Mh] Termos MeSH secundário: Composição de Bases/genética Carnivoridade Cromossomos de Plantas/genética Variação Genética/genética Filogenia [Pt] Tipo de publicação: JOURNAL ARTICLE [Em] Mês de entrada: 1708 [Cu] Atualização por classe: 170822 [Lr] Data última revisão: 170822 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 161228 [St] Status: MEDLINE [do] DOI: 10.1093/aob/mcw229

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[PMID]: 27353064 [Au] Autor: Butts CT; Bierma JC; Martin RW [Ad] Endereço: Department of Electrical Engineering and Computer Science, UC Irvine, Irvine, California, 92697. rwmartin@uci.edu. [Ti] Título: Novel proteases from the genome of the carnivorous plant Drosera capensis: Structural prediction and comparative analysis. [So] Source: Proteins;84(10):1517-33, 2016 Oct. [Is] ISSN: 1097-0134 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: In his 1875 monograph on insectivorous plants, Darwin described the feeding reactions of Drosera flypaper traps and predicted that their secretions contained a "ferment" similar to mammalian pepsin, an aspartic protease. Here we report a high-quality draft genome sequence for the cape sundew, Drosera capensis, the first genome of a carnivorous plant from order Caryophyllales, which also includes the Venus flytrap (Dionaea) and the tropical pitcher plants (Nepenthes). This species was selected in part for its hardiness and ease of cultivation, making it an excellent model organism for further investigations of plant carnivory. Analysis of predicted protein sequences yields genes encoding proteases homologous to those found in other plants, some of which display sequence and structural features that suggest novel functionalities. Because the sequence similarity to proteins of known structure is in most cases too low for traditional homology modeling, 3D structures of representative proteases are predicted using comparative modeling with all-atom refinement. Although the overall folds and active residues for these proteins are conserved, we find structural and sequence differences consistent with a diversity of substrate recognition patterns. Finally, we predict differences in substrate specificities using in silico experiments, providing targets for structure/function studies of novel enzymes with biological and technological significance. Proteins 2016; 84:1517-1533. © 2016 Wiley Periodicals, Inc. [Mh] Termos MeSH primário: Carnivoridade/fisiologia Drosera/genética Droseraceae/genética Genoma de Planta Peptídeo Hidrolases/química Proteínas de Plantas/química [Mh] Termos MeSH secundário: Sequência de Aminoácidos Domínio Catalítico Mapeamento de Sequências Contíguas Drosera/classificação Droseraceae/classificação Sequenciamento de Nucleotídeos em Larga Escala Simulação de Acoplamento Molecular Anotação de Sequência Molecular Peptídeo Hidrolases/genética Peptídeo Hidrolases/metabolismo Filogenia Proteínas de Plantas/genética Proteínas de Plantas/metabolismo Domínios Proteicos Dobramento de Proteína Estrutura Secundária de Proteína Alinhamento de Sequência Homologia Estrutural de Proteína Especificidade por Substrato [Pt] Tipo de publicação: COMPARATIVE STUDY; JOURNAL ARTICLE [Nm] Nome de substância: 0 (Plant Proteins); EC 3.4.- (Peptide Hydrolases) [Em] Mês de entrada: 1706 [Cu] Atualização por classe: 171001 [Lr] Data última revisão: 171001 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 160630 [St] Status: MEDLINE [do] DOI: 10.1002/prot.25095

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[PMID]: 27197216 [Au] Autor: Bemm F; Becker D; Larisch C; Kreuzer I; Escalante-Perez M; Schulze WX; Ankenbrand M; Van de Weyer AL; Krol E; Al-Rasheid KA; Mithöfer A; Weber AP; Schultz J; Hedrich R [Ad] Endereço: Center for Computational and Theoretical Biology, Campus Hubland Nord; Department of Bioinformatics, Biocenter, Am Hubland, University of Würzburg, D-97218 Würzburg, Germany; [Ti] Título: Venus flytrap carnivorous lifestyle builds on herbivore defense strategies. [So] Source: Genome Res;26(6):812-25, 2016 06. [Is] ISSN: 1549-5469 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Although the concept of botanical carnivory has been known since Darwin's time, the molecular mechanisms that allow animal feeding remain unknown, primarily due to a complete lack of genomic information. Here, we show that the transcriptomic landscape of the Dionaea trap is dramatically shifted toward signal transduction and nutrient transport upon insect feeding, with touch hormone signaling and protein secretion prevailing. At the same time, a massive induction of general defense responses is accompanied by the repression of cell death-related genes/processes. We hypothesize that the carnivory syndrome of Dionaea evolved by exaptation of ancient defense pathways, replacing cell death with nutrient acquisition. [Mh] Termos MeSH primário: Droseraceae/genética [Mh] Termos MeSH secundário: Droseraceae/citologia Droseraceae/metabolismo Genoma de Planta Herbivoria Folhas de Planta/citologia Folhas de Planta/genética Folhas de Planta/metabolismo Proteínas de Plantas/biossíntese Proteínas de Plantas/genética Proteínas de Plantas/secreção Transdução de Sinais Transcriptoma [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Plant Proteins) [Em] Mês de entrada: 1704 [Cu] Atualização por classe: 170403 [Lr] Data última revisão: 170403 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 160520 [St] Status: MEDLINE [do] DOI: 10.1101/gr.202200.115

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[PMID]: 27174967 [Au] Autor: Stokstad E [Ti] Título: PLANT SCIENCE. How the Venus flytrap acquired its taste for meat. [So] Source: Science;352(6287):756, 2016 May 13. [Is] ISSN: 1095-9203 [Cp] País de publicação: United States [La] Idioma: eng [Mh] Termos MeSH primário: Digestão Droseraceae/fisiologia Droseraceae/parasitologia Cadeia Alimentar Gryllidae [Mh] Termos MeSH secundário: Animais Evolução Biológica Ciclopentanos/metabolismo Droseraceae/genética Regulação da Expressão Gênica de Plantas Genoma de Planta Oxilipinas/metabolismo Reguladores de Crescimento de Planta/secreção [Pt] Tipo de publicação: NEWS [Nm] Nome de substância: 0 (Cyclopentanes); 0 (Oxylipins); 0 (Plant Growth Regulators); 6RI5N05OWW (jasmonic acid) [Em] Mês de entrada: 1606 [Cu] Atualização por classe: 160513 [Lr] Data última revisão: 160513 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 160514 [St] Status: MEDLINE [do] DOI: 10.1126/science.352.6287.756

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[PMID]: 27098087 [Au] Autor: Simura J; Spíchal L; Adamec L; Pencík A; Rolcík J; Novák O; Strnad M [Ad] Endereço: Laboratory of Growth Regulators, Centre of the Region Haná for Biotechnological and Agricultural Research, Institute of Experimental Botany AS CR and Faculty of Science of Palacký University, Slechtitelu 27, CZ-78371 Olomouc, Czech Republic Department of Chemical Biology and Genetics, Centre of the [Ti] Título: Cytokinin, auxin and physiological polarity in the aquatic carnivorous plants Aldrovanda vesiculosa and Utricularia australis. [So] Source: Ann Bot;117(6):1037-44, 2016 May. [Is] ISSN: 1095-8290 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: BACKGROUND AND AIMS: The typical rootless linear shoots of aquatic carnivorous plants exhibit clear, steep polarity associated with very rapid apical shoot growth. The aim of this study was to determine how auxin and cytokinin contents are related to polarity and shoot growth in such plants. METHODS: The main auxin and cytokinin metabolites in separated shoot segments and turions of two carnivorous plants, Aldrovanda vesiculosa and Utricularia australis, were analysed using ultra-high-performance liquid chromatography coupled with triple quad mass spectrometry. KEY RESULTS: In both species, only isoprenoid cytokinins were identified. Zeatin cytokinins predominated in the apical parts, with their concentrations decreasing basipetally, and the trans isomer predominated in A. vesiculosa whereas the cis form was more abundant in U australis. Isopentenyladenine-type cytokinins, in contrast, increased basipetally. Conjugated cytokinin metabolites, the O-glucosides, were present at high concentrations in A. vesiculosa but only in minute amounts in U. australis. N(9)-glucoside forms were detected only in U. australis, with isopentenyladenine-9-glucoside (iP9G) being most abundant. In addition to free indole-3-acetic acid (IAA), indole-3-acetamide (IAM), IAA-aspartate (IAAsp), IAA-glutamate (IAGlu) and IAA-glycine (IAGly) conjugates were identified. CONCLUSIONS: Both species show common trends in auxin and cytokinin levels, the apical localization of the cytokinin biosynthesis and basipetal change in the ratio of active cytokinins to auxin, in favour of auxin. However, our detailed study of cytokinin metabolic profiles also revealed that both species developed different regulatory mechanisms of active cytokinin content; on the level of their degradation, in U. australis, or in the biosynthesis itself, in the case of A. vesiculosa Results indicate that the rapid turnover of these signalling molecules along the shoots is essential for maintaining the dynamic balance between the rapid polar growth and development of the apical parts and senescence of the older, basal parts of the shoots. [Mh] Termos MeSH primário: Citocininas/metabolismo Ácidos Indolacéticos/metabolismo Magnoliopsida/fisiologia [Mh] Termos MeSH secundário: Organismos Aquáticos Carnivoridade Droseraceae/fisiologia Brotos de Planta/metabolismo [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Cytokinins); 0 (Indoleacetic Acids); 6U1S09C61L (indoleacetic acid); 879-37-8 (indoleacetamide) [Em] Mês de entrada: 1707 [Cu] Atualização por classe: 171116 [Lr] Data última revisão: 171116 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 160422 [St] Status: MEDLINE [do] DOI: 10.1093/aob/mcw020

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