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Pesquisa : B01.650.940.800.575.912.250.198.500.675 [Categoria DeCS]
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  1 / 29 MEDLINE  
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[PMID]:28874151
[Au] Autor:Lee YM; Shon EJ; Kim OS; Kim DS
[Ad] Endereço:Korean Medicine Convergence Research Division, Korea Institute of Oriental Medicine (KIOM), 1672 Yuseong-daero, Yuseong-gu, Daejeon, 34054, South Korea.
[Ti] Título:Effects of Mollugo pentaphylla extract on monosodium urate crystal-induced gouty arthritis in mice.
[So] Source:BMC Complement Altern Med;17(1):447, 2017 Sep 06.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Gout is an inflammatory condition induced by the deposition of monosodium urate (MSU) crystals in joints and soft tissues, and it can lead to acute or chronic arthritis. MSU are pro-inflammatory stimuli that can initiate, amplify and sustain an intense inflammatory response. In this study, we evaluated the anti-inflammatory effect of an extract of Mollugo pentaphylla (MPE) on MSU-induced gouty arthritis in a mouse model. METHOD: An MSU crystal suspension (4 mg/50 µL) was injected intradermally into the right paw. The mice were orally administered MPE (150 mg/kg or 300 mg/kg) or the positive control drug colchicine (1 mg/kg) 1 h before the MSU crystals were injected and then once daily for 3 days. The effects of MPE included inflammatory paw edema and pain upon weight-bearing activity, and we evaluated the inflammatory cytokine expression and paw tissue inflammation-related gene expression. RESULTS: MPE suppressed inflammatory paw edema and pain in the MSU-induced mice. MPE showed anti-inflammatory activity by inhibiting the production of TNF-α, interleukin (IL)-1ß, NLRP3 inflammasome and NF-κB. CONCLUSION: These results suggest that MPE has potent anti-inflammatory activities and may be useful as a therapeutic agent against gouty arthritis.
[Mh] Termos MeSH primário: Artrite Experimental/tratamento farmacológico
Artrite Gotosa/tratamento farmacológico
Molluginaceae/química
Extratos Vegetais/uso terapêutico
[Mh] Termos MeSH secundário: Animais
Artrite Experimental/induzido quimicamente
Artrite Experimental/fisiopatologia
Artrite Gotosa/induzido quimicamente
Artrite Gotosa/fisiopatologia
Comportamento Animal/efeitos dos fármacos
Citocinas/sangue
Edema/fisiopatologia
/fisiopatologia
Masculino
Camundongos
Camundongos Endogâmicos C57BL
Medição da Dor
Extratos Vegetais/farmacologia
Ácido Úrico/efeitos adversos
Suporte de Carga
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Cytokines); 0 (Plant Extracts); 268B43MJ25 (Uric Acid)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170925
[Lr] Data última revisão:
170925
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170907
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-1955-1


  2 / 29 MEDLINE  
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[PMID]:28671248
[Au] Autor:Ali MA; Lee J; Al-Hemaid F
[Ad] Endereço:Department of Botany and Microbiology, College of Science, , , Saudi Arabia alimohammad@ksu.edu.sa.
[Ti] Título:Generic relationships among Molluginaceae inferred from a molecular phylogenetic analysis of the matK gene.
[So] Source:Genet Mol Res;16(2), 2017 Jun 29.
[Is] ISSN:1676-5680
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:The family Molluginaceae (order Caryophyllales) is considered polyphyletic based on the photosynthetic pathway, C evolution, and phylogeny of the family. This inference was made based on photosynthetic, anatomical, and molecular datasets. The generic circumscription of this family has greatly been changed owing to the placement of several of its genera into the Caryophyllaceae, Microteaceae, Lophiocarpaceae, and Limeaceae families. However, the generic relationships are largely unknown. By virtue of high substitution rates within the species and the ability to resolve the phylogenetic position of morphologically very closely related species and species complexes, the matK gene has emerged as one of the potential chloroplast DNA molecular markers in plant molecular phylogenetics and DNA barcoding studies. We herein used molecular phylogenetic analyses of matK gene sequences using maximum parsimony and maximum likelihood analyses to infer the generic relationships among currently recognized genera circumscribed under the family Molluginaceae. The resulting phylogenetic tree confirmed the polyphyly of the family Molluginaceae. The genus Hypertelis was found at the base of the Molluginaceae clade. The genus Glinus was close to Glischrothamnus and Mollugo, Suessenguthiella was close to Coelanthum and Pharnaceum, whereas Polpoda grouped with Adenogramma and Psammotropha. The present study constitutes a robust investigation of the molecular phylogenetic relationships among members of the family Molluginaceae. Future study should combine by combined analyses of morphological characters and multiple nuclear and chloroplast DNA sequences with a more comprehensive taxon sampling of the family Molluginaceae.
[Mh] Termos MeSH primário: Genes de Cloroplastos
Molluginaceae/genética
Filogenia
[Mh] Termos MeSH secundário: Molluginaceae/classificação
Polimorfismo Genético
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171019
[Lr] Data última revisão:
171019
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170704
[St] Status:MEDLINE
[do] DOI:10.4238/gmr16029295


  3 / 29 MEDLINE  
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[PMID]:25341314
[Au] Autor:Vasincu A; Miron A; Bild V
[Ti] Título:Preliminary research concerning antinociceptive and antiinflammatory effects of two extracts from Glinus oppositifolius (L.) Aug. DC.
[So] Source:Rev Med Chir Soc Med Nat Iasi;118(3):866-72, 2014 Jul-Sep.
[Is] ISSN:0048-7848
[Cp] País de publicação:Romania
[La] Idioma:eng
[Ab] Resumo:UNLABELLED: In Mali Glinus oppositifolius (L.) Aug. DC. (Aizoaceae) is used to treat inflammations and joint pains. AIM: The present study was designed to evaluate the antinociceptive and anti-inflammatory effects of the aqueous and ethanol extracts obtained from the aerial parts of the plant. MATERIAL AND METHODS: The aqueous and ethanol extracts (G-A1 and G-E1, respectively) were studied regarding their acute toxicity. The extracts were further evaluated in different models using nociceptive (chemical, thermal, mechanical) and inflammatory stimuli. Experimental protocol was implemented according to international regulations in animal experiments. RESULTS AND DISCUSSIONS: No acute toxicity was noticed for these two extracts. ED50 (mg/kg bw) values were determined in different nociception models: the constrictive abdominal response test (G-A1: 229.00 +/- 53.30; G-E1: 146.38 +/- 31.75), hot plate test (G-A1: 278.59 +/- 73.00; G-E1: 383.52 +/- 89.69), Randall-Selitto test (G-A1: 207.14 +/- 26.15), evaluation of the inflammatory edema test (G-A1: 228.31 +/- 13.84; G-E1: 62.55 +/- 89.69). CONCLUSIONS: The results of the inflammatory nociception studies show that G-E1 extract had a higher potency than G-A1 extract in the constrictive abdominal response test. Also, for the same level of anti-inflammatory activity, G-E1 extract was more potent than G-A1 extract. These results encourage further studies to separate, isolate and identify the phytochemicals responsible for the analgesic and anti-inflammatory effects.
[Mh] Termos MeSH primário: Analgésicos/farmacologia
Anti-Inflamatórios/farmacologia
Molluginaceae
Fitoterapia
Componentes Aéreos da Planta
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Analgésicos/química
Animais
Anti-Inflamatórios/química
Artralgia/tratamento farmacológico
Seres Humanos
Inflamação/tratamento farmacológico
Fitoterapia/métodos
Extratos Vegetais/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Analgesics); 0 (Anti-Inflammatory Agents); 0 (Plant Extracts)
[Em] Mês de entrada:1412
[Cu] Atualização por classe:141024
[Lr] Data última revisão:
141024
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:141025
[St] Status:MEDLINE


  4 / 29 MEDLINE  
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[PMID]:25076732
[Au] Autor:Vasincu A; Paulsen BS; Diallo D; Bild V; Miron A
[Ti] Título:Antioxidant activities and phenolic contents of extracts from Glinus oppositifolius aerial parts.
[So] Source:Rev Med Chir Soc Med Nat Iasi;118(2):564-70, 2014 Apr-Jun.
[Is] ISSN:0048-7848
[Cp] País de publicação:Romania
[La] Idioma:eng
[Ab] Resumo:UNLABELLED: In Malian traditional medicine, aerial parts of Glinus oppositifolius are used in the treatment of many disorders, particularly inflammations and joint pains. AIM: The present study was initiated to investigate the antioxidant potential of Glinus oppositifolius. MATERIAL AND METHODS: Aqueous and ethanol extracts were prepared from the dried aerial parts. Both extracts were examined for the phenolic content and antioxidant activity. Total phenolic content was quantified by Folin-Ciocalteu method. Antioxidant activity was studied in vitro by evaluating the ability to scavenge different free radicals (ABTS, superoxide and hydroxyl radicals, nitric oxide) and to chelate ferrous ions. RESULTS: Aqueous extract was found to contain a higher level of total phenols than ethanol extract (1.27 +/- 0.04 vs. 0.94 +/- 0.05 g GAE/100 g extract). Both extracts lacked the ability to scavenge superoxide anion radical but scavenged ABTS and hydroxyl radicals, nitric oxide and chelated ferrous ions in a concentration-dependent manner. According to the EC50 values, aqueous extract showed stronger antioxidant effects than ethanol extract (174.32 +/- 1.49 vs. 276.76 +/- 1.52 microg/mL in ABTS radical cation scavenging assay, 119.91 +/- 1.70 vs. 240.57 +/- 0.97 microg/mL in nitric oxide scavenging assay, 1.99 +/- 0.01 vs. 6.54 +/- 0.08 mg/mL in ferrous ion chelating assay). In hydroxyl radical scavenging assay, aqueous extract had an EC50 value of 0.86 +/- 0.00 mg/mL while the EC50 value of ethanol extract was higher than the highest concentration that was tested (3.75 mg/mL). CONCLUSIONS: Our results clearly indicate the antioxidant potential of Glinus oppositifolius aerial parts and suggest that the antiinflammatory activity might be partly related to the antioxidant potential.
[Mh] Termos MeSH primário: Anti-Inflamatórios/análise
Anti-Inflamatórios/farmacologia
Antioxidantes
Molluginaceae
Fenóis/análise
Fenóis/farmacologia
Fitoterapia
Componentes Aéreos da Planta
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Anti-Inflamatórios/química
Fenóis/química
Fitoterapia/métodos
Extratos Vegetais/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Antioxidants); 0 (Phenols); 0 (Plant Extracts)
[Em] Mês de entrada:1410
[Cu] Atualização por classe:140731
[Lr] Data última revisão:
140731
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140801
[St] Status:MEDLINE


  5 / 29 MEDLINE  
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[PMID]:24713133
[Au] Autor:Kiros G; Erko B; Giday M; Mekonnen Y
[Ti] Título:Laboratory assessment of molluscicidal and cercariacidal effects of Glinus lotoides fruits.
[So] Source:BMC Res Notes;7:220, 2014 Apr 08.
[Is] ISSN:1756-0500
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The negative impact of synthetic molluscicides on the environment and their high cost necessitated search for an alternative approach of using plant extracts for the control of schistosomiasis. The objective of this study was, therefore, to evaluate aqueous and ethyl acetate crude extracts of Glinus lotoides fruits for their cercariacidal activity and molluscicidal effect against schistosome snail intermediate hosts. METHODS: Assessment of the molluscicidal activity against Biomphalaria pfeifferi was made by immersion method in accordance with WHO guideline. The results of mortality were statistically analyzed using probit analysis. The attenuating effect of the plant on Schistosoma mansoni cercariae was determined using establishment of adult worms as a parasitological parameter post exposure. RESULTS: The 24 and 48 hour-LC50 values for the aqueous extract of G. lotoides fruits were 47.1 and 44.1 mg/L, respectively, whereas that of ethyl acetate were 66.1 and 59.6 mg/L, respectively. The 24 and 48 hour LC90 values for the aqueous extract of G. lotoides fruits were 56.96 and 51.0 mg/L, respectively, while that of ethyl acetate were 77.2 and 70.0 mg/L, respectively. The in vitro cercariacidal activity was determined after 2 hrs of exposure to the aqueous plant extract. It was found out that the LC50 and LC90 values were 18.7 and 41.7 mg/L, respectively. Besides, infectivity of Schistosoma mansoni cercariae to mice was determined by exposing mice to cercariae pre-treated with the sub-lethal concentrations (3.7, 11.6 and 18.7 mg/L) of the aqueous extract. A significant reduction in worm burden in mice was obtained at 11.6 mg/L (p < 0.05). Moreover, the reduction in number of worms recovered was highly significant at 18.7 mg/L (p < 0.001). CONCLUSIONS: The results showed that G. lotoides has molluscicidal activity against B. pfeifferi snails and cercariacidal activity against S. mansoni. Yet, further comprehensive evaluation is recommended for the possible use of G. lotoides against B. pfeifferi and the schistosome parasite.
[Mh] Termos MeSH primário: Anti-Helmínticos/farmacologia
Molluginaceae/química
Moluscocidas/farmacologia
Extratos Vegetais/farmacologia
Schistosoma mansoni/efeitos dos fármacos
[Mh] Termos MeSH secundário: Acetatos
Animais
Biomphalaria/efeitos dos fármacos
Biomphalaria/fisiologia
Feminino
Frutas/química
Dose Letal Mediana
Masculino
Camundongos
Schistosoma mansoni/crescimento & desenvolvimento
Esquistossomose mansoni/tratamento farmacológico
Esquistossomose mansoni/parasitologia
Solventes
Água
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Acetates); 0 (Anthelmintics); 0 (Molluscacides); 0 (Plant Extracts); 0 (Solvents); 059QF0KO0R (Water); 76845O8NMZ (ethyl acetate)
[Em] Mês de entrada:1411
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140410
[St] Status:MEDLINE
[do] DOI:10.1186/1756-0500-7-220


  6 / 29 MEDLINE  
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[PMID]:24617922
[Au] Autor:Sheu SY; Yao CH; Lei YC; Kuo TF
[Ad] Endereço:School of Chinese Medicine, China Medical University , Taichung, Taiwan , ROC .
[Ti] Título:Recent progress in Glinus oppositifolius research.
[So] Source:Pharm Biol;52(8):1079-84, 2014 Aug.
[Is] ISSN:1744-5116
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:CONTEXT: Glinus oppositifolius (L.) Aug. DC. (Molluginaceae), a perennial subshrubs herb, grows at low altitudes in the southern part of Taiwan, and is used in traditional Chinese medicine for herpes zoster and herpangina. OBJECTIVE: This study describes nutritional and therapeutic potential of Glinus oppositifolius and summarizes scientific evidence that supports traditional claims; recent progress in research for this plant is reviewed herein. MATERIALS AND METHODS: The literature has been retrieved from the web-based online systems including PubMed, Medline, and Google Scholar. The articles related to phytochemistry, pharmaceutical biology and ethnopharmacology have been excluded. RESULTS AND DISCUSSION: In clinical practice, the plant has been extensively investigated in a broad range of studies to provide scientific evidence for folklore claims or to find new therapeutic uses. The present review may arouse related research and make a more valid display for Taiwanese native medicinal plants.
[Mh] Termos MeSH primário: Medicamentos de Ervas Chinesas/química
Medicamentos de Ervas Chinesas/uso terapêutico
Molluginaceae
Fitoterapia/tendências
[Mh] Termos MeSH secundário: Animais
Medicamentos de Ervas Chinesas/isolamento & purificação
Seres Humanos
Taiwan
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Drugs, Chinese Herbal)
[Em] Mês de entrada:1503
[Cu] Atualização por classe:140714
[Lr] Data última revisão:
140714
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140313
[St] Status:MEDLINE
[do] DOI:10.3109/13880209.2013.876653


  7 / 29 MEDLINE  
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[PMID]:24008516
[Au] Autor:Brockington S; Dos Santos P; Glover B; De Craene LR
[Ad] Endereço:Department of Plant Sciences, University of Cambridge, Cambridge, CB2 3EA, UK.
[Ti] Título:Androecial evolution in Caryophyllales in light of a paraphyletic Molluginaceae.
[So] Source:Am J Bot;100(9):1757-78, 2013 Sep.
[Is] ISSN:1537-2197
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:PREMISE OF THE STUDY: Caryophyllales are highly diverse in the structure of the perianth and androecium and show a mode of floral development unique in eudicots, reflecting the continuous interplay of gynoecium and perianth and their influence on position, number, and identity of the androecial whorls. The floral development of five species from four genera of a paraphyletic Molluginaceae (Limeum, Hypertelis, Glinus, Corbichonia), representing three distinct evolutionary lineages, was investigated to interpret the evolution of the androecium across Caryophyllales. • METHODS: Floral buds were dissected, critical-point dried and imaged with SEM. The genera studied are good representatives of the diversity of development of stamens and staminodial petaloids in Caryophyllales. • KEY RESULTS: Sepals show evidence of petaloid differentiation via marginal hyaline expansion. Corbichonia, Glinus, and Limeum also show perianth differentiation via sterilization of outer stamen tiers. In all four genera, stamens initiate with the carpels and develop centrifugally, but subsequently variation is significant. With the exception of Limeum, the upper whorl is complete and alternisepalous, while a second antesepalous whorl arises more or less sequentially, starting opposite the inner sepals. Loss or sterilization of antesepalous stamens occurs in Glinus and Limeum and is caused by altered carpel merism and inhibition by sepal pressures. • CONCLUSIONS: Outer stamens of Hypertelis correspond with petaloids of Caryophyllaceae and suggest that staminodial petaloids and outer alternisepalous stamens are interchangeable in the Caryophyllales. We emphasize a switch in the position of first formed stamens from antesepalous to alternisepalous following the divergence of Limeum; thus stamen position is an important synapomorphy for the globular inclusion clade.
[Mh] Termos MeSH primário: Caryophyllaceae/anatomia & histologia
Flores/anatomia & histologia
[Mh] Termos MeSH secundário: Evolução Biológica
Caryophyllaceae/genética
Caryophyllaceae/crescimento & desenvolvimento
Flores/genética
Flores/crescimento & desenvolvimento
Microscopia Eletrônica de Varredura
Molluginaceae/anatomia & histologia
Molluginaceae/genética
Molluginaceae/crescimento & desenvolvimento
Filogenia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1404
[Cu] Atualização por classe:130916
[Lr] Data última revisão:
130916
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130907
[St] Status:MEDLINE
[do] DOI:10.3732/ajb.1300083


  8 / 29 MEDLINE  
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[PMID]:23583553
[Au] Autor:Ogburn RM; Edwards EJ
[Ad] Endereço:Department of Ecology and Evolutionary Biology, Brown University, 80 Waterman Street, Box G-W, Providence, RI 02912, USA. matthew.ogburn@yale.edu
[Ti] Título:Repeated origin of three-dimensional leaf venation releases constraints on the evolution of succulence in plants.
[So] Source:Curr Biol;23(8):722-6, 2013 Apr 22.
[Is] ISSN:1879-0445
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Succulent water storage is a prominent feature among plants adapted to arid zones, but we know little about how succulence evolves and how it is integrated into organs already tasked with multiple functions. Increased volume in succulent leaves, for example, may result in longer transport distances between veins and the cells that they supply, which in turn could negatively impact photosynthesis. We quantified water storage in a group of 83 closely related species to examine the evolutionary dynamics of succulence and leaf venation. In most leaves, vein density decreased with increasing succulence, resulting in significant increases in the path length of water from veins to evaporative surfaces. The most succulent leaves, however, had a distinct three-dimensional (3D) venation pattern, which evolved 11-12 times within this small lineage, likely via multiple developmental pathways. 3D venation "resets" internal leaf distances, maintaining moderate vein density in extremely succulent tissues and suggesting that the evolution of extreme succulence is constrained by the need to maintain an efficient leaf hydraulic system. The repeated evolution of 3D venation decouples leaf water storage from hydraulic path length, facilitating the evolutionary exploration of novel phenotypic space.
[Mh] Termos MeSH primário: Evolução Biológica
Magnoliopsida/anatomia & histologia
Magnoliopsida/fisiologia
Filogenia
Folhas de Planta/anatomia & histologia
Folhas de Planta/fisiologia
[Mh] Termos MeSH secundário: Adaptação Fisiológica
Transporte Biológico
Magnoliopsida/classificação
Magnoliopsida/genética
Dados de Sequência Molecular
Molluginaceae/anatomia & histologia
Molluginaceae/classificação
Molluginaceae/genética
Molluginaceae/fisiologia
Folhas de Planta/classificação
Folhas de Planta/genética
Proteínas de Plantas/genética
Proteínas de Plantas/metabolismo
Análise de Sequência de DNA
Água/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, U.S. GOV'T, NON-P.H.S.
[Nm] Nome de substância:
0 (Plant Proteins); 059QF0KO0R (Water)
[Em] Mês de entrada:1311
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130416
[St] Status:MEDLINE


  9 / 29 MEDLINE  
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[PMID]:22648529
[Au] Autor:Demma J; El-Seedi H; Engidawork E; Aboye TL; Göransson U; Hellman B
[Ad] Endereço:Department of Pharmaceutical Biosciences, Division of Toxicology, Uppsala University, Uppsala, Sweden.
[Ti] Título:An in vitro study on the DNA damaging effects of phytochemicals partially isolated from an extract of Glinus lotoides.
[So] Source:Phytother Res;27(4):507-14, 2013 Apr.
[Is] ISSN:1099-1573
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:An extract of Glinus lotoides, a medicinal plant used in Africa and Asia for various therapeutic purposes, was recently shown to cause DNA damage in vitro. To further explore the potential genotoxicity of this plant, fractionation of the crude extract was performed using reverse phase solid-phase extraction and a stepwise gradient elution of methanol in water. Four fractions were collected and subsequently analysed for their DNA damaging effects in mouse lymphoma cells using an alkaline version of the comet assay. To identify potential genotoxic and non-genotoxic principles, each fraction was then subjected to liquid chromatography coupled to mass spectrometry, LC-MS/MS. 1D and 2D nuclear magnetic resonance analyses were used to confirm the identity of some saponins. Although fractions containing a mixture of flavonoids and oleanane-type saponins or oleanane-type saponins alone produced no DNA damage, those containing hopane-type saponins exhibited a pronounced DNA damaging effect without affecting the viability of the cells. To conclude, even if this study presents evidence that hopane-type of saponins are endowed with a DNA damaging ability, further studies are needed before individual saponins can be cited as a culprit for the previously reported genotoxicity of the crude extract of G. lotoides.
[Mh] Termos MeSH primário: Dano ao DNA
Molluginaceae/química
Extratos Vegetais/toxicidade
Saponinas/toxicidade
Triterpenos/toxicidade
[Mh] Termos MeSH secundário: Animais
Linhagem Celular Tumoral
Cromatografia Líquida
Ensaio Cometa
Camundongos
Ácido Oleanólico/análogos & derivados
Ácido Oleanólico/toxicidade
Plantas Medicinais/química
Espectrometria de Massas em Tandem
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Plant Extracts); 0 (Saponins); 0 (Triterpenes); 0 (oleanane); 471-62-5 (hopane); 6SMK8R7TGJ (Oleanolic Acid)
[Em] Mês de entrada:1307
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:120601
[St] Status:MEDLINE
[do] DOI:10.1002/ptr.4744


  10 / 29 MEDLINE  
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[PMID]:22594571
[Au] Autor:Kumar D; Shah V; Ghosh R; Pal BC
[Ad] Endereço:Department of Natural Products , National Institute of Pharmaceutical Education and Research, 4 Raja S.C. Mullick Road, Jadavpur, Kolkata, India.
[Ti] Título:A new triterpenoid saponin from Glinus oppositifolius with α-glucosidase inhibitory activity.
[So] Source:Nat Prod Res;27(7):624-9, 2013 Apr.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Evaluation of α-glucosidase inhibitory activity led to the isolation of six triterpene saponins from the aerial parts of Glinus oppositifolius including one new and five known constituents. The structure of the new saponin, glinoside C (1), was established as 16-O-(ß-D-glucopyranosyl)-3ß,12ß,16ß,21α,22-pentahydroxy hopane by extensive use of 1-D, 2-D NMR and mass spectral techniques. The other constituents identified were 3-O-(ß-D-xylopyranosyl)-spergulagenin A (2), spergulacin (3), spergulin A (4), spergulacin A (5) and spergulin B (6). Compound 1 exhibited the greatest inhibition of the enzyme with IC50 of 127 ± 30 µM. Kinetics study for the compound 1 demonstrated mixed type of inhibition (Ki = 157.9 µM).
[Mh] Termos MeSH primário: Inibidores de Glicosídeo Hidrolases
Molluginaceae/química
Saponinas/química
Triterpenos/química
Triterpenos/farmacologia
[Mh] Termos MeSH secundário: Espectroscopia de Ressonância Magnética
Estrutura Molecular
Saponinas/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Glycoside Hydrolase Inhibitors); 0 (Saponins); 0 (Triterpenes)
[Em] Mês de entrada:1309
[Cu] Atualização por classe:141120
[Lr] Data última revisão:
141120
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:120519
[St] Status:MEDLINE
[do] DOI:10.1080/14786419.2012.686907



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