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Pesquisa : B01.650.940.800.575.912.250.198.500.750 [Categoria DeCS]
Referências encontradas : 118 [refinar]
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[PMID]:28337741
[Au] Autor:Bose M; Kamra M; Mullick R; Bhattacharya S; Das S; Karande AA
[Ad] Endereço:Department of Biochemistry, Indian Institute of Science, Bangalore, India.
[Ti] Título:A plant-derived dehydrorotenoid: a new inhibitor of hepatitis C virus entry.
[So] Source:FEBS Lett;591(9):1305-1317, 2017 May.
[Is] ISSN:1873-3468
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Emergence of drug-resistant viruses, high cost and adverse side-effects associated with the standard therapy against hepatitis C virus (HCV) infection demonstrate the need for development of well tolerated and effective antivirals. We identified and chemically characterised the dehydrorotenoid boeravinone H, isolated from the herb Boerhavia diffusa, as a new inhibitor of HCV entry. The compound significantly inhibits the binding and entry of hepatitis C-like particles (HCV-LPs) in hepatoma cells in vitro with no apparent cytotoxicity. Boeravinone H inhibits the initial phase of HCV entry probably by acting directly on the viral particle. Importantly, the compound prevents HCV entry and infection in cell culture (ex vivo). Thus, boeravinone H is a potential antiviral agent for the prevention and control of HCV infection.
[Mh] Termos MeSH primário: Flavonoides/farmacologia
Hepacivirus/efeitos dos fármacos
Extratos Vegetais/farmacologia
Internalização do Vírus/efeitos dos fármacos
[Mh] Termos MeSH secundário: Carcinoma Hepatocelular/patologia
Carcinoma Hepatocelular/virologia
Linhagem Celular Tumoral
Sobrevivência Celular/efeitos dos fármacos
Relação Dose-Resposta a Droga
Flavonoides/química
Hepacivirus/fisiologia
Interações Hospedeiro-Patógeno/efeitos dos fármacos
Seres Humanos
Neoplasias Hepáticas/patologia
Neoplasias Hepáticas/virologia
Microscopia Confocal
Microscopia de Fluorescência
Estrutura Molecular
Nyctaginaceae/química
Extratos Vegetais/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Flavonoids); 0 (Plant Extracts); 0 (dehydrorotenone)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170918
[Lr] Data última revisão:
170918
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170325
[St] Status:MEDLINE
[do] DOI:10.1002/1873-3468.12629


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[PMID]:28068633
[Au] Autor:A P; Varghese MV; S A; P SR; Mathew AK; Nair A; Nair RH; K G R
[Ad] Endereço:Biochemistry and Molecular Mechanism Laboratory, Agroprocessing and Technology Division, CSIR-National Institute for Interdisciplinary Science and Technology (NIIST), Pappanamcode, Trivandrum, Kerala, India.
[Ti] Título:Polyphenol rich ethanolic extract from Boerhavia diffusa L. mitigates angiotensin II induced cardiac hypertrophy and fibrosis in rats.
[So] Source:Biomed Pharmacother;87:427-436, 2017 Mar.
[Is] ISSN:1950-6007
[Cp] País de publicação:France
[La] Idioma:eng
[Ab] Resumo:Boerhavia diffusa is a renowned edible medicinal plant extensively used against different ailments including heart diseases in the traditional system of medicine in several countries. The present study aims to evaluate the therapeutic efficacy of ethanolic extract of Boerhavia diffusa (BDE) on cardiac hypertrophy and fibrosis induced by angiotensin II (Ang II) in male wistar rats and to identify the active components present in it. A substantial increase of hypertrophy markers such as cardiac mass index, concentration of ANP and BNP, cardiac injury markers like CK-MB, LDH and SGOT, has been observed in hypertrophied groups whereas BDE treatment attenuated these changes when compared to hypertrophied rats. Moreover, Ang II induced myocardial oxidative stress was reduced by BDE which was apparent from diminished level of lipid and protein oxidation products, increased activities of membrane bound ATPases and endogenous antioxidant enzymes along with enhanced translocation of Nrf2 from the cytosol to nucleus. It appears that BDE evokes its antioxidant effects by attenuating lipid peroxidation, enhancing the translocation of Nrf2 from the cytoplasm to nucleus as well as by regulating the metabolism of glutathione. The extent of fibrosis during cardiac hypertrophy was determined by histopathology analysis and the results revealed that BDE treatment considerably reduced the fibrosis in the heart. HPLC analysis of BDE leads to the identification of four compounds viz., quercetin, kaempferol, boeravinone B and caffeic acid. The study substantiate the effect of B. diffusa in protecting the heart from pathological hypertrophy and the attenuation of cardiac abnormalities may be partly attributed through the reduction of oxidative stress and cardiac fibrosis. Since the plant is widely used as a green leafy vegetable, incorporation of this plant in diet may be an alternative way for the prevention and better management of heart diseases and associated complications.
[Mh] Termos MeSH primário: Angiotensina II/farmacologia
Cardiomegalia/induzido quimicamente
Cardiomegalia/tratamento farmacológico
Fibrose/induzido quimicamente
Fibrose/tratamento farmacológico
Nyctaginaceae/química
Polifenóis/farmacologia
[Mh] Termos MeSH secundário: Animais
Antioxidantes/metabolismo
Cardiomegalia/metabolismo
Etanol/química
Fibrose/metabolismo
Glutationa/metabolismo
Coração/efeitos dos fármacos
Peroxidação de Lipídeos/efeitos dos fármacos
Masculino
Miocárdio/metabolismo
Estresse Oxidativo/efeitos dos fármacos
Extratos Vegetais/farmacologia
Plantas Medicinais/química
Quercetina/farmacologia
Ratos
Ratos Wistar
Espécies Reativas de Oxigênio/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Plant Extracts); 0 (Polyphenols); 0 (Reactive Oxygen Species); 11128-99-7 (Angiotensin II); 3K9958V90M (Ethanol); 9IKM0I5T1E (Quercetin); GAN16C9B8O (Glutathione)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170224
[Lr] Data última revisão:
170224
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170110
[St] Status:MEDLINE


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[PMID]:27608964
[Au] Autor:Tupe RS; Kemse NG; Khaire AA; Shaikh SA
[Ad] Endereço:a Biochemical Sciences Division, Rajiv Gandhi Institute of IT and Biotechnology , Bharati Vidyapeeth University , Pune , Maharashtra , India.
[Ti] Título:Attenuation of glycation-induced multiple protein modifications by Indian antidiabetic plant extracts.
[So] Source:Pharm Biol;55(1):68-75, 2017 Dec.
[Is] ISSN:1744-5116
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:CONTEXT: Protein glycation is the major contributing factor in the development of diabetic complications. The antiglycation potential of medicinal plants provides a promising opportunity as complementary interventions for complications. OBJECTIVE: To investigate the antiglycation potential of 19 medicinal plants extracts using albumin by estimating different indicators: (1) glycation (early and late), (2) albumin oxidation, and (3) amyloid aggregation. MATERIALS AND METHODS: The effect of aqueous plant extracts (1% w/v) on protein glycation was assessed by incubating albumin (10 mg/mL) with fructose (250 mM) for 4 days. Degree of protein glycation in the absence and presence of plant extracts was assessed by estimating fructosamine, advanced glycation end products (AGEs), carbonyls, free thiol group and ß-amyloid aggregation. RESULTS: Petroselinum crispum, Boerhavia diffusa, Terminalia chebula, Swertia chirayita and Glycyrrhiza glabra showed significant antiglycating activity. P. crispum and A. barbadensis inhibited the carbonyl stress and protected the thiol group from oxidative damage. There was significant correlation between protein thiols and amyloid inhibition (R = -.69, p < .001). CONCLUSION: P. crispum, B. diffusa and T. chebula had the most potent antiglycation activity. These plant exerted noticeable antiglycation activity at different glycation modifications of albumin. These findings are important for identifying plants with potential to combat diabetic complications.
[Mh] Termos MeSH primário: Peptídeos beta-Amiloides/metabolismo
Produtos Finais de Glicação Avançada/metabolismo
Hipoglicemiantes/farmacologia
Nyctaginaceae/química
Petroselinum/química
Extratos Vegetais/farmacologia
Processamento de Proteína Pós-Traducional/efeitos dos fármacos
Soroalbumina Bovina/metabolismo
Terminalia/química
[Mh] Termos MeSH secundário: Frutosamina/metabolismo
Frutose/metabolismo
Glicosilação
Hipoglicemiantes/isolamento & purificação
Índia
Oxirredução
Fitoterapia
Extratos Vegetais/isolamento & purificação
Plantas Medicinais
Agregação Patológica de Proteínas
Carbonilação Proteica/efeitos dos fármacos
Compostos de Sulfidrila/metabolismo
Fatores de Tempo
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Amyloid beta-Peptides); 0 (Glycation End Products, Advanced); 0 (Hypoglycemic Agents); 0 (Plant Extracts); 0 (Sulfhydryl Compounds); 0 (advanced glycation end products-bovine serum albumin); 27432CM55Q (Serum Albumin, Bovine); 30237-26-4 (Fructose); 4429-04-3 (Fructosamine)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160910
[St] Status:MEDLINE


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[PMID]:27667768
[Au] Autor:Karwasra R; Kalra P; Nag TC; Gupta YK; Singh S; Panwar A
[Ad] Endereço:Department of Pharmacology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 110029, India.
[Ti] Título:Safety assessment and attenuation of cisplatin induced nephrotoxicity by tuberous roots of Boerhaavia diffusa.
[So] Source:Regul Toxicol Pharmacol;81:341-352, 2016 Nov.
[Is] ISSN:1096-0295
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Cisplatin (Cis-diaminedichloroplatinum II) is a chemotherapeutic agent having well documented adverse effect as nephrotoxicity. This study was designed to evaluate the nephroprotective role of Boerhaavia diffusa in cisplatin-induced acute kidney injury. Wistar rats (n = 6) were allocated into six groups constituting normal control, cisplatin-induced, Boerhaavia diffusa root extract in doses 50, 100 and 200 mg/kg and Boerhaavia diffusa per se group, administered orally for a period of ten days. Intraperitoneal injection of cisplatin was administered on day 7, to all groups except normal control and Boerhaavia diffusa per se group. On day 10, cisplatin resulted in substantial nephrotoxicity in Wistar rats with significant (p < 0.001) elevation in serum creatinine and blood urea nitrogen, decline in the concentrations of reduced glutathione and superoxide dismutase, elevation in TNF-α level in renal tissues. Boerhaavia diffusa at a dose of 200 mg/kg body weight significantly (p < 0.001) ameliorates increased in serum creatinine, blood urea nitrogen, oxidative stress and inflammatory markers. In parallel to this, it also exhibits antiapoptotic activity through the reduction of active caspase-3 expression in kidneys. Findings indicate that Boerhaavia diffusa is effective in mitigating cisplatin-induced nephrotoxicity and thus, for this the acute and sub-acute toxicity studies conducted to evaluate the safety profile of Boerhaavia diffusa. The no-observed adverse effect level (NOAEL) of tuberous roots of Boerhaavia diffusa root extract was 1000 mg/kg.
[Mh] Termos MeSH primário: Lesão Renal Aguda/metabolismo
Antineoplásicos/toxicidade
Cisplatino/antagonistas & inibidores
Cisplatino/toxicidade
Nyctaginaceae/química
Extratos Vegetais/farmacologia
Raízes de Plantas/química
[Mh] Termos MeSH secundário: Lesão Renal Aguda/induzido quimicamente
Lesão Renal Aguda/patologia
Administração Oral
Animais
Antineoplásicos/administração & dosagem
Cisplatino/administração & dosagem
Relação Dose-Resposta a Droga
Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos
Injeções Intraperitoneais
Masculino
Extratos Vegetais/administração & dosagem
Extratos Vegetais/isolamento & purificação
Ratos
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Plant Extracts); Q20Q21Q62J (Cisplatin)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170704
[Lr] Data última revisão:
170704
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160927
[St] Status:MEDLINE


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[PMID]:27394387
[Au] Autor:Ortega YH; Mosquera DMG; Galapththi S; Santos BT; González GS; Foubert K; Pieters L; Calderon PB; Apers S
[Ad] Endereço:Department of Pharmacy, Central University "Marta Abreu" of Las Villas, Cuba.
[Ti] Título:Safety assessment of a traditionally used extract from leaves of Boldoa purpurascens.
[So] Source:J Ethnopharmacol;192:302-308, 2016 Nov 04.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:ETHNOPHARMACOLOGICAL RELEVANCE: Boldoa purpurascens Cav. (Nyctaginaceae) is a plant species used in traditional medicine in Cuba as a diuretic. AIM OF THE STUDY: The aim of the present investigation was to evaluate the safety profile of a hydroalcoholic extract from leaves of Boldoa purpurascens. MATERIALS AND METHODS: First, an experimental study to assess the oral acute toxicity at a dose of 2000mg/kg body weight of the extract was carried out. Potential genotoxicity of the extract was evaluated using the Ames test and the micronucleus induction assay in mouse bone marrow. In the Ames test a concentration range of 50, 100, 150, 300 and 500µg/plate was tested. In the micronucleus induction assay, doses of 500, 1000 and 2000mg/kg of body weight were tested. For completeness, since the extract contains saponins, the evaluation of the hemolytic activity, ocular and skin irritation were included. RESULTS: No signs or symptoms of toxicity were observed in the oral acute toxicity test (body weight at baseline, seven days and end of the experiment of 236.41±20.07, 256.81±30.44 and 240.02±26.16 respectively for the treated group). The hydroalcoholic extract from the leaves was not mutagenic in the Ames test, and no genotoxicity was observed in the micronucleus assay. A hemolysis test at concentration of 1mg/mL confirmed hemolytic activity, which is not a safety concern since saponins are not absorbed after oral administration. In order to evaluate the percentage of protein denaturation, the ocular irritability index was calculated. The extract was found to be irritating. Finally, skin irritability was evaluated and the irritation index was equal to zero. CONCLUSIONS: Based on the toxicological evaluation of a traditionally used hydroalcoholic extract from the leaves of Boldoa purpurascens we can confirm the safety of its oral use.
[Mh] Termos MeSH primário: Nyctaginaceae/toxicidade
Extratos Vegetais/toxicidade
Folhas de Planta/toxicidade
[Mh] Termos MeSH secundário: Administração Oral
Animais
Células da Medula Óssea/efeitos dos fármacos
Células da Medula Óssea/patologia
DNA Bacteriano/efeitos dos fármacos
DNA Bacteriano/genética
Dermatite de Contato/etiologia
Dermatite de Contato/patologia
Olho/efeitos dos fármacos
Olho/metabolismo
Proteínas do Olho/metabolismo
Feminino
Hemólise/efeitos dos fármacos
Masculino
Camundongos Endogâmicos BALB C
Micronúcleos com Defeito Cromossômico/induzido quimicamente
Testes para Micronúcleos
Mutação
Nyctaginaceae/química
Fitoterapia
Extratos Vegetais/administração & dosagem
Extratos Vegetais/isolamento & purificação
Folhas de Planta/química
Plantas Medicinais
Desnaturação Proteica
Coelhos
Ratos Sprague-Dawley
Ratos Wistar
Medição de Risco
Testes de Irritação da Pele
Solventes/química
Fatores de Tempo
Testes de Toxicidade Aguda
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Bacterial); 0 (Eye Proteins); 0 (Plant Extracts); 0 (Solvents)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170912
[Lr] Data última revisão:
170912
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160711
[St] Status:MEDLINE


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[PMID]:27383484
[Au] Autor:Nazneen F; Sheikh MA; Jameel A; Rahman Z
[Ad] Endereço:Department of Biochemistry and University of Agriculture, Faisalabad, Pakistan.
[Ti] Título:Phytochemical screening, antiglycation and antioxidant activities of whole plant of Boerhavia repens L. from Cholistan, Pakistan.
[So] Source:Pak J Pharm Sci;29(3 Suppl):1063-70, 2016 May.
[Is] ISSN:1011-601X
[Cp] País de publicação:Pakistan
[La] Idioma:eng
[Ab] Resumo:Present study was aimed to explore a traditionally used indigenous medicinal plant Boerhavia repens (Nyctaginaceae family) of the Cholistan desert, Pakistan. Crude aqueous and methanolic extracts of the whole plant were investigated in vitro for preliminary phytochemical screening, antioxidant and antiglycation activities. Antioxidant activities were determined by total phenolic contents, 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging and inhibition of lipid peroxidation. For antiglycation activities browning production was noted and thiobarbituric acid (TBA) technique was used to determine glycation level. Boerhavia repens expressed considerable amounts of phytochemicals. Extract yield was found to be 4.59%-7.85% g/100g of dry matter with total phenolics ranging from 47.9- 190.77mg/GAE per g for aqueous and methanol extract respectively. Strong inhibitory effect was exhibited by methanolic extract in linoleic acid per oxidation system (86.11%, EC50=0.99mg/mL) and DPPH assay (88.65%, EC50=212.33µg/ml). In term of browning maximum inhibition (81.50%) was exhibited by methanolic extract at 37°C at third week of incubation. Both extracts expressed significant (P>0.05) and comparable inhibition of glycation level. In conclusion, Boerhavia repens showed promising antioxidant and antiglycation activities validating its therapeutic potential.
[Mh] Termos MeSH primário: Depuradores de Radicais Livres/farmacologia
Produtos Finais de Glicação Avançada/metabolismo
Hipoglicemiantes/farmacologia
Peroxidação de Lipídeos/efeitos dos fármacos
Estresse Oxidativo/efeitos dos fármacos
Fenóis/farmacologia
Extratos Vegetais/farmacologia
Albumina Sérica/metabolismo
[Mh] Termos MeSH secundário: Compostos de Bifenilo/química
Depuradores de Radicais Livres/química
Depuradores de Radicais Livres/isolamento & purificação
Seres Humanos
Hipoglicemiantes/química
Hipoglicemiantes/isolamento & purificação
Metanol/química
Nyctaginaceae/química
Paquistão
Fenóis/química
Fenóis/isolamento & purificação
Fitoterapia
Picratos/química
Extratos Vegetais/química
Extratos Vegetais/isolamento & purificação
Plantas Medicinais
Albumina Sérica Humana
Solventes/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biphenyl Compounds); 0 (Free Radical Scavengers); 0 (Glycation End Products, Advanced); 0 (Hypoglycemic Agents); 0 (Phenols); 0 (Picrates); 0 (Plant Extracts); 0 (Serum Albumin); 0 (Solvents); 0 (advanced glycation end products-human serum albumin); DFD3H4VGDH (1,1-diphenyl-2-picrylhydrazyl); Y4S76JWI15 (Methanol); ZIF514RVZR (Serum Albumin, Human)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160708
[St] Status:MEDLINE


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[PMID]:27283631
[Au] Autor:Al-Farga A; Zhang H; Siddeeg A; Shamoon M; V M Chamba M; Al-Hajj N
[Ad] Endereço:State Key Laboratory of Food Science and Technology & School of Food Science and Technology, Jiangnan University, 1800 Lihu Avenue, Wuxi 214122, PR China.
[Ti] Título:Proximate composition, functional properties, amino acid, mineral and vitamin contents of a novel food: Alhydwan (Boerhavia elegana Choisy) seed flour.
[So] Source:Food Chem;211:268-73, 2016 Nov 15.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Alhydwan (Boerhavia elegana Choisy) seed flour was evaluated for chemical and nutritional composition, and functional properties in a pursuit to identify an innovative plant with high nutraceuticals value which could be exploited in other food applications. The flour was found to be rich in dietary fiber (30.13%), protein (14.60%), crude fat (11.49%), carbohydrates (30.77%), and ash (6.88%) and encompassed adequate amounts of essential amino acids and minerals, whereas, sucrose constituted 71.3% of total sugar contents. Vitamins analysis revealed that flour is rich in water-soluble vitamins such as Thiamin (B1), Riboflavin (B2) and Niacin (B3), to the amounts of 19.3, 8.2 and 2.3mg/100g, respectively. Results on functional properties demonstrated high water and oil absorption capacities of 6.31 and 2.43g/g, respectively. Foaming capacity, foam stability and emulsion capacity were 9.35%, 6.90%, and 29.60%, respectively. It can be concluded that alhydwan is an excellent food material with a high nutritional value.
[Mh] Termos MeSH primário: Aminoácidos/análise
Farinha/análise
Minerais/análise
Nyctaginaceae/química
Sementes/química
Vitaminas/análise
[Mh] Termos MeSH secundário: Carboidratos da Dieta/análise
Fibras na Dieta/análise
Abastecimento de Alimentos/métodos
Valor Nutritivo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Amino Acids); 0 (Dietary Carbohydrates); 0 (Dietary Fiber); 0 (Minerals); 0 (Vitamins)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160611
[St] Status:MEDLINE


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[PMID]:27106082
[Au] Autor:Yang EJ; Lee W; Song KS; Bae JS
[Ad] Endereço:College of Pharmacy, CMRI, Research Institute of Pharmaceutical Sciences, BK21 Plus KNU Multi-Omics based Creative Drug Research Team, Kyungpook National University, Daegu 41566, Republic of Korea.
[Ti] Título:Ameliorative effect of a rarely occurring C-methylrotenoid on HMGB1-induced septic responses in vitro and in vivo.
[So] Source:Biochem Pharmacol;110-111:58-70, 2016 Jun 15.
[Is] ISSN:1873-2968
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The ubiquitous nuclear protein, high mobility group box-1 (HMGB1) functions as a late mediator of sepsis. A new rarely occurring C-methylrotenoid, named boeravinone X (comp 1), was isolated and identified from Abronia nana suspension cultures during our continuous works on the discovery of anti-septic natural products. Here, we investigated the antiseptic effects and underlying mechanisms of comp 1 against HMGB1-mediated septic responses. According to the results, comp 1 effectively inhibited lipopolysaccharide (LPS)-induced release of HMGB1, and suppressed HMGB1-mediated septic responses, such as hyperpermeability, adhesion and migration of leukocytes, and expression of cell adhesion molecules. And, comp 1 suppressed the production of tumor necrosis factor alpha (TNF-α) and interleukin 6 (IL-6), and the activation of nuclear factor-κB (NF-κB) and extracellular signal-regulated kinases 1 and 2 (ERK1/2) by HMGB1. Collectively, these results indicate that comp 1 could be potential therapeutic agents for the treatment of various severe vascular inflammatory diseases via inhibition of the HMGB1 signaling pathway.
[Mh] Termos MeSH primário: Anti-Inflamatórios/farmacologia
Benzopiranos/farmacologia
Flavonoides/farmacologia
Regulação da Expressão Gênica/efeitos dos fármacos
Proteína HMGB1/genética
Nyctaginaceae/química
Sepse/tratamento farmacológico
[Mh] Termos MeSH secundário: Animais
Anti-Inflamatórios/isolamento & purificação
Benzopiranos/isolamento & purificação
Movimento Celular/efeitos dos fármacos
Movimento Celular/imunologia
Flavonoides/isolamento & purificação
Proteína HMGB1/antagonistas & inibidores
Proteína HMGB1/imunologia
Proteína HMGB1/secreção
Células Endoteliais da Veia Umbilical Humana
Seres Humanos
Interleucina-6/antagonistas & inibidores
Interleucina-6/genética
Interleucina-6/imunologia
Leucócitos/efeitos dos fármacos
Leucócitos/imunologia
Leucócitos/patologia
Lipopolissacarídeos
Masculino
Camundongos
Camundongos Endogâmicos C57BL
Proteína Quinase 1 Ativada por Mitógeno/antagonistas & inibidores
Proteína Quinase 1 Ativada por Mitógeno/genética
Proteína Quinase 1 Ativada por Mitógeno/imunologia
Proteína Quinase 3 Ativada por Mitógeno/antagonistas & inibidores
Proteína Quinase 3 Ativada por Mitógeno/genética
Proteína Quinase 3 Ativada por Mitógeno/imunologia
NF-kappa B/antagonistas & inibidores
NF-kappa B/genética
NF-kappa B/imunologia
Extratos Vegetais/química
Sepse/induzido quimicamente
Sepse/genética
Sepse/patologia
Transdução de Sinais
Fator de Necrose Tumoral alfa/antagonistas & inibidores
Fator de Necrose Tumoral alfa/genética
Fator de Necrose Tumoral alfa/imunologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Benzopyrans); 0 (Flavonoids); 0 (HMGB1 Protein); 0 (HMGB1 protein, mouse); 0 (Interleukin-6); 0 (Lipopolysaccharides); 0 (NF-kappa B); 0 (Plant Extracts); 0 (Tumor Necrosis Factor-alpha); 0 (boeravinone X); 0 (interleukin-6, mouse); EC 2.7.11.24 (Mapk1 protein, mouse); EC 2.7.11.24 (Mitogen-Activated Protein Kinase 1); EC 2.7.11.24 (Mitogen-Activated Protein Kinase 3)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170502
[Lr] Data última revisão:
170502
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160424
[St] Status:MEDLINE


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[PMID]:26963142
[Au] Autor:Do LT; Aree T; Siripong P; Pham TN; Nguyen PK; Tip-Pyang S
[Ad] Endereço:Natural Products Research Unit, Department of Chemistry, Faculty of Science, Chulalongkorn University , Bangkok 10330, Thailand.
[Ti] Título:Bougainvinones A-H, Peltogynoids from the Stem Bark of Purple Bougainvillea spectabilis and Their Cytotoxic Activity.
[So] Source:J Nat Prod;79(4):939-45, 2016 Apr 22.
[Is] ISSN:1520-6025
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Eight new peltogynoids, named bougainvinones A-H (1-8), were obtained from the stem bark of Bougainvillea spectabilis. Their structures were elucidated by means of physical data (1D and 2D NMR, HRESIMS) and single-crystal X-ray crystallographic analyses. The peltogynoids, a rare type of modified flavonoids, are reported for the first time from this species of the genus Bougainvillea. All isolated compounds were evaluated for their cytotoxic effects against five cancer cell lines including KB, Hela S-3, HT-29, MCF-7, and HepG2. Among them, compound 7 showed cytotoxicity against five cancer cell lines with IC50 values in the 7.4-9.7 µM range, and compounds 2 and 3 exhibited cytotoxicity against the KB cell line with IC50 values of 6.6 and 9.0 µM.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/isolamento & purificação
Antineoplásicos Fitogênicos/farmacologia
Flavonoides/isolamento & purificação
Flavonoides/farmacologia
Nyctaginaceae/química
[Mh] Termos MeSH secundário: Antineoplásicos Fitogênicos/química
Linhagem Celular Tumoral
Cristalografia por Raios X
Ensaios de Seleção de Medicamentos Antitumorais
Flavonoides/química
Células HT29
Células HeLa
Células Hep G2
Seres Humanos
Concentração Inibidora 50
Células KB
Conformação Molecular
Estrutura Molecular
Casca de Planta/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Flavonoids); 0 (bougainvinone G)
[Em] Mês de entrada:1609
[Cu] Atualização por classe:160422
[Lr] Data última revisão:
160422
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160311
[St] Status:MEDLINE
[do] DOI:10.1021/acs.jnatprod.5b00996


  10 / 118 MEDLINE  
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[PMID]:26844923
[Au] Autor:Patil KS; Bhalsing SR
[Ad] Endereço:Department of Biotechnology, School of Life Sciences, North Maharashtra University, Jalgaon 425001, Maharashtra, India.
[Ti] Título:Ethnomedicinal uses, phytochemistry and pharmacological properties of the genus Boerhavia.
[So] Source:J Ethnopharmacol;182:200-20, 2016 Apr 22.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:ETHNOPHARMACOLOGICAL RELEVANCE: The genus Boerhavia is widely distributed in tropical, subtropical and temperate regions of the world including Mexico, America, Africa, Asia, Indian Ocean Islands, Pacific Islands and Australia. The genus Boerhavia is extensively used by local peoples and medicinal practitioners for treatments of hepatitis, urinary disorders, gastro intestinal diseases, inflammations, skin problems, infectious diseases and asthma. Present review focused on traditional uses, phytochemistry, pharmacology and toxicology of Boerhavia genus to support potential scope for advance ethnopharmacological study. MATERIALS AND METHODS: Information on the Boerhavia species was collected from classical books on medicinal plants, pharmacopoeias and scientific databases like PubMed, Scopus, GoogleScholar, Web of Science and others. Also scientific literatures based on ethnomedicinal surveys, Ph.D. and M.Sc. dissertations, published papers from Elsevier, Taylor and Francis, Springer, ACS as well as Wiley publishers and reports by government bodies and documentations were assessed. RESULTS: A total of 180 compounds from Boerhavia genus were isolated of which B. diffusa alone shared around 131 compounds and for most of which it is currently an exclusive source. In the genus, phenolic glycosides and flavonoids contribute approximately 97 compounds. These includes eupalitin, rotenoids like boeravinones, coccineons, alkaloid i.e. betanin and punarnavine etc., showing vital pharmaceutical activities such as anticancer, anti-inflammatory, antioxidant and immunomodulatory. CONCLUSION: Boerhavia is an important genus with wide range of medicinal uses. However, most of the available scientific literatures have lacked relevant doses, duration and positive controls for examining bioefficacy of extracts and its active compounds. In some studies, taxonomic errors were encountered. Moreover, there is need for accurate methods in testing the safety and ethnomedicinal validity of Boerhavia species.
[Mh] Termos MeSH primário: Nyctaginaceae
Fitoterapia
[Mh] Termos MeSH secundário: Animais
Seres Humanos
Medicina Tradicional
Nyctaginaceae/química
Nyctaginaceae/toxicidade
Compostos Fitoquímicos/análise
Compostos Fitoquímicos/farmacologia
Compostos Fitoquímicos/uso terapêutico
Compostos Fitoquímicos/toxicidade
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T; REVIEW
[Nm] Nome de substância:
0 (Phytochemicals)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160205
[St] Status:MEDLINE



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