Base de dados : MEDLINE Pesquisa : B01.650.940.800.575.912.250.198.500.750.500 [Categoria DeCS] Referências encontradas : 56 [refinar] Mostrando: 1 .. 10   no formato [Detalhado]

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[PMID]: 28646396 [Au] Autor: Yan L; Li C; Zhang J; Moodley O; Liu S; Lan C; Gao Q; Zhang W [Ad] Endereço: College of Resource and Environmental Science, Jilin Agricultural University, Changchun, 130118, China. [Ti] Título: Enhanced Phytoextraction of Lead from Artificially Contaminated Soil by Mirabilis jalapa with Chelating Agents. [So] Source: Bull Environ Contam Toxicol;99(2):208-212, 2017 Aug. [Is] ISSN: 1432-0800 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: A microcosm experiment was conducted to compare how different chelating agents enhance the phytoextraction of lead (Pb) by Mirabilis jalapa from an artificially Pb-contaminated soil. Chelating agents used included ethylene diamine tetraacetic acid (EDTA), nitrilotriacetic acid (NTA), ethylene diamine disuccinic acid (EDDS), oxalic acid, humic acid, citric acid and tartaric acid, with concentrations ranging from 0 to 2000 mg/kg. Results show that with increasing concentrations of chelating agents, the concentrations, bioaccumulation coefficients, and translocation factors of Pb in M. jalapa gradually increased. Of all chelating agents used, the concentrations, bioaccumulation coefficients and translocation factors of Pb in M. jalapa were higher for EDTA and NTA than for the other chelating agents. Given the potential environmental risks of EDTA, we recommend NTA be used as a suitable chelating agent to increase the phytoremediation of Pb-contaminated soil with M. jalapa. [Mh] Termos MeSH primário: Quelantes/química Recuperação e Remediação Ambiental/métodos Chumbo/metabolismo Mirabilis/fisiologia Poluentes do Solo/metabolismo [Mh] Termos MeSH secundário: Biodegradação Ambiental Ácido Edético Etilenodiaminas Chumbo/análise Solo Poluentes do Solo/análise [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Chelating Agents); 0 (Ethylenediamines); 0 (Soil); 0 (Soil Pollutants); 2P299V784P (Lead); 60V9STC53F (ethylenediamine); 9G34HU7RV0 (Edetic Acid) [Em] Mês de entrada: 1709 [Cu] Atualização por classe: 171116 [Lr] Data última revisão: 171116 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170625 [St] Status: MEDLINE [do] DOI: 10.1007/s00128-017-2127-1

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[PMID]: 28342034 [Au] Autor: Kulshreshtha A; Roshan P; Sharma D; Hallan V [Ad] Endereço: Academy of Scientific and Innovative Research (AcSIR), CSIR-Institute of Himalayan Bioresource Technology, Palampur, Himachal Pradesh, 176061, India. [Ti] Título: Molecular characterization of a new begomovirus infecting Mirabilis jalapa in northern India. [So] Source: Arch Virol;162(7):2163-2167, 2017 Jul. [Is] ISSN: 1432-8798 [Cp] País de publicação: Austria [La] Idioma: eng [Ab] Resumo: Begomoviruses are whitefly-transmitted single-stranded DNA viruses that are responsible for considerable economic losses. A begomovirus, alphasatellite and betasatellite were characterized in a Mirabilis jalapa plant exhibiting severe leaf curling and mottling symptoms. The complete viral genome shared highest sequence identity of 87% with pedilanthus leaf curl virus (AM712436), reported from Pakistan. Additionally, the viral genome was 84% identical to that of chilli leaf curl India virus (KX951415) and 83% identical to that of tobacco curly shoot virus (GU1999584), which were previously reported to infect M. jalapa in India and China, respectively. Based on the ICTV criterion for begomovirus species demarcation (≥91% sequence identity for the complete genome), the virus represents a new species, for which we propose the name Mirabilis leaf curl virus. The alphasatellite and betasatellite sequences were similar to the corresponding sequences of ageratum yellow vein India alphasatellite (KU852743; 99% identity) and tomato leaf curl Patna betasatellite (HQ180394; 86% identity) sequences, respectively. This report describes a new begomovirus-satellite disease complex in M. jalapa. [Mh] Termos MeSH primário: Begomovirus/classificação Mirabilis/virologia Filogenia Doenças das Plantas/virologia [Mh] Termos MeSH secundário: Begomovirus/genética Begomovirus/isolamento & purificação DNA de Cadeia Simples/genética DNA Viral/genética Genoma Viral Índia Folhas de Planta/virologia Análise de Sequência de DNA [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (DNA, Single-Stranded); 0 (DNA, Viral) [Em] Mês de entrada: 1708 [Cu] Atualização por classe: 170802 [Lr] Data última revisão: 170802 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170326 [St] Status: MEDLINE [do] DOI: 10.1007/s00705-017-3330-4

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[PMID]: 28108917 [Au] Autor: Chen S; Ma H; Guo Z; Feng Y; Lin J; Zhang M; Zhong M [Ad] Endereço: Key Laboratory of Agricultural Biotechnology of Liaoning Province, College of Bioscience and Biotechnology, Shenyang Agricultural University, No. 120 Dongling Road, Shenhe District, Shenyang, 110866, China. [Ti] Título: Quantitative proteomics analysis reveals the tolerance of Mirabilis jalapa L. to petroleum contamination. [So] Source: Environ Sci Pollut Res Int;24(8):7375-7382, 2017 Mar. [Is] ISSN: 1614-7499 [Cp] País de publicação: Germany [La] Idioma: eng [Ab] Resumo: Petroleum is not only an important energy resource but is also a major soil pollutant. To gain better insight into the adaptability mechanism of Mirabilis jalapa to petroleum-contaminated soil, the protein profiles of M. jalapa root were investigated using label-free quantitative proteomics technique. After exposing to petroleum-contaminated soil for 24 h, 34 proteins significantly changed their protein abundance and most of the proteins increased in protein abundance (91.18%). Combined with gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses as well as data from previous studies, our results revealed that M. jalapa enhanced tolerance to petroleum by changing antioxidation and detoxification, cell wall organization, amino acid and carbohydrate metabolism, transportation and protein process, and so on. These metabolism alterations could result in the production and secretion of low molecular carbohydrate, amino acid, and functional protein, which enhanced the bioavailability of petroleum and reducing the toxicity of the petroleum. Taken together, these results provided novel information for better understanding of the tolerance of M. jalapa to petroleum stress. [Mh] Termos MeSH primário: Mirabilis Petróleo/toxicidade Proteínas de Plantas Proteoma Poluentes do Solo/toxicidade [Mh] Termos MeSH secundário: Mirabilis/efeitos dos fármacos Mirabilis/genética Mirabilis/metabolismo Mirabilis/fisiologia Proteínas de Plantas/análise Proteínas de Plantas/genética Proteínas de Plantas/metabolismo Raízes de Plantas/genética Raízes de Plantas/metabolismo Raízes de Plantas/fisiologia Proteoma/efeitos dos fármacos Proteoma/metabolismo Proteômica [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Petroleum); 0 (Plant Proteins); 0 (Proteome); 0 (Soil Pollutants) [Em] Mês de entrada: 1706 [Cu] Atualização por classe: 171104 [Lr] Data última revisão: 171104 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170122 [St] Status: MEDLINE [do] DOI: 10.1007/s11356-017-8403-0

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[PMID]: 27931116 [Au] Autor: Zhou SY; Wang GW; Zou YL; Deng LQ; Liu MX; Liao ZH; Lan XZ; Chen M [Ad] Endereço: a Key Laboratory of Luminescent and Real-Time Analytical Chemistry, Ministry of Education, College of Pharmaceutical Sciences , Southwest University , Chongqing , P.R. China. [Ti] Título: A new diphenyl ether derivative from Mirabilis himalaica. [So] Source: Nat Prod Res;31(9):1034-1041, 2017 May. [Is] ISSN: 1478-6427 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: One new compound, himalain A (1), together with 12 known compounds were isolated from Mirabilis himalaica. Their structures were determined by spectroscopic methods, including 2D NMR techniques, and the absolute configuration of the 1,2-diol moiety in 1 was defined through Riguera's method. All isolated compounds were tested for their cytotoxic and antibacterial activities. [Mh] Termos MeSH primário: Mirabilis/química Éteres Fenílicos/isolamento & purificação [Mh] Termos MeSH secundário: Antibacterianos/farmacologia Antineoplásicos Fitogênicos/farmacologia Linhagem Celular Tumoral Seres Humanos Éteres Fenílicos/química Éteres Fenílicos/farmacologia [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Anti-Bacterial Agents); 0 (Antineoplastic Agents, Phytogenic); 0 (Phenyl Ethers) [Em] Mês de entrada: 1706 [Cu] Atualização por classe: 170817 [Lr] Data última revisão: 170817 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 161210 [St] Status: MEDLINE [do] DOI: 10.1080/14786419.2016.1266351

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[PMID]: 27221930 [Au] Autor: Wicaksono PA; Name S; Martien R; Ismail H [Ad] Endereço: Postgraduated School of Biotechnology, Universitas Gadjah Mada, Yogyakarta, Indonesia E-mail : sismindari@ugm.ac.id. [Ti] Título: Formulation and Cytotoxicity of Ribosome-Inactivating Protein Mirabilis Jalapa L. Nanoparticles Using Alginate-Low Viscosity Chitosan Conjugated with Anti-Epcam Antibodies in the T47D Breast Cancer Cell Line. [So] Source: Asian Pac J Cancer Prev;17(4):2277-84, 2016. [Is] ISSN: 2476-762X [Cp] País de publicação: Thailand [La] Idioma: eng [Ab] Resumo: Ribosome-inactivating protein (RIP) from Mirabilis jalapa L. leaves has cytotoxic effects on breast cancer cell lines but is less toxic towards normal cells. However, it can easily be degraded after administration so it needs to be formulated into nanoparticles to increase its resistance to enzymatic degradation. The objectives of this study were to develop a protein extract of M. jalapa L. leaves (RIP-MJ) incorporated into nanoparticles conjugated with Anti-EpCAM antibodies, and to determine its cytotoxicity and selectivity in the T47D breast cancer cell line. RIP-MJ was extracted from red-flowered M. jalapa L. leaves. Nanoparticles were formulated based on polyelectrolyte complexation using low viscosity chitosan and alginate, then chemically conjugated with anti-EpCAM antibody using EDAC based on carbodiimide reaction. RIP-MJ nanoparticles were characterised for the particle size, polydispersity index, zeta potential, particle morphology, and entrapment efficiency. The cytotoxicity of RIP-MJ nanoparticles against T47D and Vero cells was then determined with MTT assay. The optimal formula of RIP-MJ nanoparticles was obtained at the concentration of RIP-MJ, low viscosity chitosan and alginate respectively 0.05%, 1%, and 0.4% (m/v). RIP-MJ nanoparticles are hexagonal with high entrapment efficiency of 98.6%, average size of 130.7 nm, polydispersity index of 0.380 and zeta potential +26.33 mV. The IC50 values of both anti-EpCAM-conjugated and non-conjugated RIP-MJ nanoparticles for T47D cells (13.3 and 14.9 µg/mL) were lower than for Vero cells (27.8 and 33.6 µg/mL). The IC50 values of conjugated and non- conjugated RIP-MJ for both cells were much lower than IC50 values of non-formulated RIP-MJ (>500 µg/mL). [Mh] Termos MeSH primário: Anticorpos Monoclonais/farmacologia Neoplasias da Mama/tratamento farmacológico Neoplasias da Mama/patologia Molécula de Adesão da Célula Epitelial/antagonistas & inibidores Mirabilis/química Nanopartículas/química Extratos Vegetais/farmacologia Proteínas Inativadoras de Ribossomos/metabolismo [Mh] Termos MeSH secundário: Alginatos/química Apoptose/efeitos dos fármacos Western Blotting Neoplasias da Mama/metabolismo Proliferação Celular/efeitos dos fármacos Química Farmacêutica Quitosana/química Molécula de Adesão da Célula Epitelial/imunologia Feminino Citometria de Fluxo Ácido Glucurônico/química Ácidos Hexurônicos/química Seres Humanos Nanopartículas/administração & dosagem Tamanho da Partícula Folhas de Planta/química Células Tumorais Cultivadas Viscosidade [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Alginates); 0 (Antibodies, Monoclonal); 0 (Epithelial Cell Adhesion Molecule); 0 (Hexuronic Acids); 0 (Plant Extracts); 8A5D83Q4RW (Glucuronic Acid); 8C3Z4148WZ (alginic acid); 9012-76-4 (Chitosan); EC 3.2.2.22 (Ribosome Inactivating Proteins) [Em] Mês de entrada: 1701 [Cu] Atualização por classe: 170308 [Lr] Data última revisão: 170308 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 160526 [St] Status: MEDLINE

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[PMID]: 27064484 [Au] Autor: Valverde A; De Maayer P; Oberholster T; Henschel J; Louw MK; Cowan D [Ad] Endereço: Department of Genetics, Centre for Microbial Ecology and Genomics, University of Pretoria, Pretoria, South Africa. [Ti] Título: Specific Microbial Communities Associate with the Rhizosphere of Welwitschia mirabilis, a Living Fossil. [So] Source: PLoS One;11(4):e0153353, 2016. [Is] ISSN: 1932-6203 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Welwitschia mirabilis is an ancient and rare plant distributed along the western coast of Namibia and Angola. Several aspects of Welwitschia biology and ecology have been investigated, but very little is known about the microbial communities associated with this plant. This study reports on the bacterial and fungal communities inhabiting the rhizosphere of W. mirabilis and the surrounding bulk soil. Rhizosphere communities were dominated by sequences of Alphaproteobacteria and Euromycetes, while Actinobacteria, Alphaproteobacteria, and fungi of the class Dothideomycetes jointly dominated bulk soil communities. Although microbial communities within the rhizosphere and soil samples were highly variable, very few "species" (OTUs defined at a 97% identity cut-off) were shared between these two environments. There was a small 'core' rhizosphere bacterial community (formed by Nitratireductor, Steroidobacter, Pseudonocardia and three Phylobacteriaceae) that together with Rhizophagus, an arbuscular mycorrhizal fungus, and other putative plant growth-promoting microbes may interact synergistically to promote Welwitschia growth. [Mh] Termos MeSH primário: Bactérias/classificação Fósseis/microbiologia Mirabilis/microbiologia Raízes de Plantas/microbiologia Rizosfera Microbiologia do Solo Solo/química [Mh] Termos MeSH secundário: Bactérias/genética Mirabilis/genética RNA Ribossômico 16S/genética [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nome de substância: 0 (RNA, Ribosomal, 16S); 0 (Soil) [Em] Mês de entrada: 1608 [Cu] Atualização por classe: 171116 [Lr] Data última revisão: 171116 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 160412 [St] Status: MEDLINE [do] DOI: 10.1371/journal.pone.0153353

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[PMID]: 26842951 [Au] Autor: Yew SM; Chan CL; Kuan CS; Toh YF; Ngeow YF; Na SL; Lee KW; Hoh CC; Yee WY; Ng KP [Ad] Endereço: Department of Medical Microbiology, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia. sumei_yew@hotmail.com. [Ti] Título: The genome of newly classified Ochroconis mirabilis: Insights into fungal adaptation to different living conditions. [So] Source: BMC Genomics;17:91, 2016 Feb 03. [Is] ISSN: 1471-2164 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: BACKGROUND: Ochroconis mirabilis, a recently introduced water-borne dematiaceous fungus, is occasionally isolated from human skin lesions and nails. We identified an isolate of O. mirabilis from a skin scraping with morphological and molecular studies. Its genome was then sequenced and analysed for genetic features related to classification and biological characteristics. RESULTS: UM 578 was identified as O. mirabilis based on morphology and internal transcribed spacer (ITS)-based phylogeny. The 34.61 Mb assembled genome with 13,435 predicted genes showed less efficiency of this isolate in plant cell wall degradation. Results from the peptidase comparison analysis with reported keratin-degrading peptidases from dermatophytes suggest that UM 578 is very unlikely to be utilising these peptidases to survive in the host. Nevertheless, we have identified peptidases from M10A, M12A and S33 families that may allow UM 578 to invade its host via extracellular matrix and collagen degradation. Furthermore, the lipases in UM 578 may have a role in supporting the fungus in host invasion. This fungus has the potential ability to synthesise melanin via the 1,8-dihydroxynaphthalene (DHN)-melanin pathway and to produce mycotoxins. The mating ability of this fungus was also inspected in this study and a mating type gene containing alpha domain was identified. This fungus is likely to produce taurine that is required in osmoregulation. The expanded gene family encoding the taurine catabolism dioxygenase TauD/TdfA domain suggests the utilisation of taurine under sulfate starvation. The expanded glutathione-S-transferase domains and RTA1-like protein families indicate the selection of genes in UM 578 towards adaptation in hostile environments. CONCLUSIONS: The genomic analysis of O. mirabilis UM 578 provides a better understanding of fungal survival tactics in different habitats. [Mh] Termos MeSH primário: Adaptação Biológica Ascomicetos/classificação Ascomicetos/genética Genoma Fúngico [Mh] Termos MeSH secundário: Adaptação Biológica/genética Ascomicetos/crescimento & desenvolvimento Ascomicetos/metabolismo Metabolismo dos Carboidratos/genética Biologia Computacional/métodos Elementos de DNA Transponíveis DNA Intergênico Genes Fúngicos Genômica Mirabilis Anotação de Sequência Molecular Família Multigênica Fenótipo Filogenia Metabolismo Secundário [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nome de substância: 0 (DNA Transposable Elements); 0 (DNA, Intergenic) [Em] Mês de entrada: 1610 [Cu] Atualização por classe: 170220 [Lr] Data última revisão: 170220 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 160205 [St] Status: MEDLINE [do] DOI: 10.1186/s12864-016-2409-8

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[PMID]: 26683006 [Au] Autor: Polturak G; Breitel D; Grossman N; Sarrion-Perdigones A; Weithorn E; Pliner M; Orzaez D; Granell A; Rogachev I; Aharoni A [Ad] Endereço: Department of Plant and Environmental Sciences, Weizmann Institute of Science, Rehovot, 7610001, Israel. [Ti] Título: Elucidation of the first committed step in betalain biosynthesis enables the heterologous engineering of betalain pigments in plants. [So] Source: New Phytol;210(1):269-83, 2016 Apr. [Is] ISSN: 1469-8137 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: Betalains are tyrosine-derived red-violet and yellow pigments, found in plants only of the Caryophyllales order. Although much progress has been made in recent years in the understanding of the betalain biosynthetic process, many questions remain open with regards to several of the proposed steps in the pathway. Most conspicuous by its absence is the characterization of the first committed step in the pathway, namely the 3-hydroxylation of tyrosine to form l-3,4-dihydroxyphenylalanine (l-DOPA). We used transcriptome analysis of the betalain-producing plants red beet (Beta vulgaris) and four o'clocks (Mirabilis jalapa) to identify a novel, betalain-related cytochrome P450-type gene, CYP76AD6, and carried out gene silencing and recombinant expression assays in Nicotiana benthamiana and yeast cells to examine its functionality. l-DOPA formation in red beet was found to be redundantly catalyzed by CYP76AD6 together with a known betalain-related enzyme, CYP76AD1, which was previously thought to only catalyze a succeeding step in the pathway. While CYP76AD1 catalyzes both l-DOPA formation and its subsequent conversion to cyclo-DOPA, CYP76AD6 uniquely exhibits only tyrosine hydroxylase activity. The new findings enabled us to metabolically engineer entirely red-pigmented tobacco plants through heterologous expression of three genes taking part in the fully decoded betalain biosynthetic pathway. [Mh] Termos MeSH primário: Beta vulgaris/genética Betalaínas/biossíntese Vias Biossintéticas Engenharia Genética/métodos Mirabilis/genética [Mh] Termos MeSH secundário: Betacianinas/biossíntese Betalaínas/química Betaxantinas/biossíntese Vias Biossintéticas/genética Sistema Enzimático do Citocromo P-450/genética Sistema Enzimático do Citocromo P-450/metabolismo Di-Hidroxifenilalanina/biossíntese Perfilação da Expressão Gênica Regulação da Expressão Gênica de Plantas Inativação Gênica Genes de Plantas Fenótipo Filogenia Pigmentação/genética Plantas Geneticamente Modificadas Proteínas Recombinantes/metabolismo Saccharomyces cerevisiae/metabolismo Tabaco/genética [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Betacyanins); 0 (Betaxanthins); 0 (Recombinant Proteins); 37279-84-8 (Betalains); 63-84-3 (Dihydroxyphenylalanine); 9035-51-2 (Cytochrome P-450 Enzyme System) [Em] Mês de entrada: 1612 [Cu] Atualização por classe: 161230 [Lr] Data última revisão: 161230 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 151220 [St] Status: MEDLINE [do] DOI: 10.1111/nph.13796

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[PMID]: 26476328 [Au] Autor: Sun Y; Zhou Q [Ad] Endereço: Innovation Team of Remediation for Heavy Metal Contaminated Farmlands, Agro-Environment Pollution Institute, Ministry of Agriculture, Tianjin 300191, China; Key Laboratory of Pollution Processes and Environmental Criteria (Ministry of Education), College of Environmental Science and Engineering, Nankai University, Tianjin 300071, China. Electronic address: sunyuebing2008@126.com. [Ti] Título: Uptake and translocation of benzo[a]pyrene (B[a]P) in two ornamental plants and dissipation in soil. [So] Source: Ecotoxicol Environ Saf;124:74-81, 2016 Feb. [Is] ISSN: 1090-2414 [Cp] País de publicação: Netherlands [La] Idioma: eng [Ab] Resumo: Pot experiments were conducted to evaluate the phytoremediation of B[a]P contaminated soil using two ornamental plants (Tagetes patula and Mirabilis jalapa). The results showed that the dry biomass of two plants was increased at low B[a]P contaminated soil and then inhibited with increasing B[a]P concentrations. It exhibited a significantly positive linear relationship between B[a]P absorption in roots, stems, leaves and shoots of the tested plants and the concentration of B[a]P in soils (P<0.01). Meanwhile, the contents of B[a]P in different tissues of the plants increased with growing time. After planting T. patula and M. jalapa, plant-promoted biodegradation of B[a]P was account for 79.5-99.8% and 71.1-99.9%, respectively, whereas the amount of B[a]P dissipation enhancement was only 0.2-20.5% and 0.1-28.9%, respectively. Moreover, low bioaccumulation factor (BF) and translocation factor (TF) values indicated that T. patula and M. jalapa took up B[a]P from contaminated soil and transferred them to the aerial parts with low efficiency. The B[a]P removal rates in rhizosphere soils at different growing stages of T. patula and M. jalapa were 2.7-26.8% and 0.4%-33.9%, respectively, higher than those of non-rhizopshere soils. Therefore, the presence of T. patula and M. jalapa roots was effective in promoting the phytoremediation of B[a]P contaminated soils. [Mh] Termos MeSH primário: Benzo(a)pireno/farmacocinética Mirabilis/metabolismo Poluentes do Solo/farmacocinética Tagetes/metabolismo [Mh] Termos MeSH secundário: Benzo(a)pireno/toxicidade Biodegradação Ambiental Biomassa Mirabilis/efeitos dos fármacos Mirabilis/crescimento & desenvolvimento Folhas de Planta/efeitos dos fármacos Folhas de Planta/crescimento & desenvolvimento Folhas de Planta/metabolismo Raízes de Plantas/efeitos dos fármacos Raízes de Plantas/crescimento & desenvolvimento Raízes de Plantas/metabolismo Brotos de Planta/efeitos dos fármacos Brotos de Planta/crescimento & desenvolvimento Brotos de Planta/metabolismo Caules de Planta/efeitos dos fármacos Caules de Planta/crescimento & desenvolvimento Caules de Planta/metabolismo Rizosfera Poluentes do Solo/toxicidade Tagetes/efeitos dos fármacos Tagetes/crescimento & desenvolvimento [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nome de substância: 0 (Soil Pollutants); 3417WMA06D (Benzo(a)pyrene) [Em] Mês de entrada: 1607 [Cu] Atualização por classe: 170910 [Lr] Data última revisão: 170910 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 151018 [St] Status: MEDLINE

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[PMID]: 26186458 [Au] Autor: Thao NP; Luyen BT; Koo JE; Kim S; Koh YS; Thanh NV; Cuong NX; Kiem PV; Minh CV; Kim YH [Ad] Endereço: a College of Pharmacy, Chungnam National University , Daejeon , Republic of Korea . [Ti] Título: In vitro anti-inflammatory components isolated from the carnivorous plant Nepenthes mirabilis (Lour.) Rafarin. [So] Source: Pharm Biol;54(4):588-94, 2016. [Is] ISSN: 1744-5116 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: CONTEXT: Nepenthes mirabilis (Lour.) Rafarin (Nepenthaceae) is a carnivorous plant used as a folk medicine in the treatment of jaundice, hepatitis, gastric ulcers, ureteral stones, diarrhea, diabetes, and high blood pressure. Neither the phytochemical content nor biological activities of N. mirabilis have been reported. OBJECTIVE: The anti-inflammatory activity from the N. mirabilis methanolic extract led to the isolation of compounds (1-26). MATERIALS AND METHODS: Chromatographic methods were used to isolate compounds from the methanol extract of N. mirabilis branches and leaves. The anti-inflammatory activity of these isolated compounds was investigated in lipopolysaccharide (LPS)-stimulated bone marrow-derived dendritic cells (BMDCs) using ELISA. Primary BMDCs were used to examine the production of pro-inflammatory cytokines (IL-12 p40, IL-6, and TNF-α, at concentrations of 0.1, 0.2, and 1.0 µM) as compared with a positive control, SB203580 (1.0 µM). MTT assays showed that isolated compounds (1-26) did not exhibit significant cytotoxicity at concentrations up to 20.0 µM. RESULTS: Compound 9 showed potent inhibition of IL-12 p40, IL-6, and TNF-α production (IC50 = 0.17 ± 0.02, 0.46 ± 0.01, and 8.28 ± 0.21 µM, respectively). Compound 4 showed potent inhibition of IL-12 p40 and IL-6 production (IC50 = 1.17 ± 0.01 and 2.15 ± 0.04 µM). In addition, IL-12 p40 inhibition by naphthalene derivatives (1-7, 9, and 10), phenolic compounds (11-15), lupeone (18), and flavonoids (22, 25, and 26) was more potent than with the positive control. The isolated compounds exhibited little and/or no inhibitory effects on TNF-α production in LPS-stimulated BMDCs. DISCUSSION AND CONCLUSION: Taken together, these data suggest that the isolated components have significant inhibitory effects on pro-inflammatory cytokine production and warrant further study concerning their potential medicinal use. [Mh] Termos MeSH primário: Anti-Inflamatórios/isolamento & purificação Células da Medula Óssea/efeitos dos fármacos Mediadores da Inflamação/antagonistas & inibidores Mirabilis Extratos Vegetais/isolamento & purificação [Mh] Termos MeSH secundário: Anti-Inflamatórios/química Anti-Inflamatórios/farmacologia Células da Medula Óssea/fisiologia Sobrevivência Celular/efeitos dos fármacos Sobrevivência Celular/fisiologia Células Cultivadas Seres Humanos Mediadores da Inflamação/fisiologia Extratos Vegetais/química Extratos Vegetais/farmacologia [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nome de substância: 0 (Anti-Inflammatory Agents); 0 (Inflammation Mediators); 0 (Plant Extracts) [Em] Mês de entrada: 1612 [Cu] Atualização por classe: 161230 [Lr] Data última revisão: 161230 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 150718 [St] Status: MEDLINE [do] DOI: 10.3109/13880209.2015.1067234

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