Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.198.500.875 [Categoria DeCS]
Referências encontradas : 39 [refinar]
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[PMID]:28762858
[Au] Autor:García-Pérez ME; Lemus-Rodríguez Z; Hung-Arbelo M; Vistel-Vigo M
[Ad] Endereço:a Laboratorio Farmacéutico Oriente , Santiago de Cuba , Cuba.
[Ti] Título:Influence of polyvinylpyrrolidone, microcrystalline cellulose and colloidal silicon dioxide on technological characteristics of a high-dose Petiveria alliacea tablet.
[So] Source:Drug Dev Ind Pharm;43(12):2011-2015, 2017 Dec.
[Is] ISSN:1520-5762
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:PURPOSE: Petiveria alliacea L. (Phytolaccaceae) is a perennial shrub used by its immunomodulatory, anticancerogenic and anti-inflammatory properties. This study determined the influence of polyvinylpyrrolidone (PVP), colloidal silicon dioxide (CSD) and microcrystalline cellulose (MC) on the technological characteristic of a high-dose P. alliacea tablet prepared by the wet granulation method. METHODOLOGY: The botanical and pharmacognostic analysis of the plant material was firstly performed, followed by a 2 factorial design considering three factors at two levels: (a) the binder (PVP) incorporated in formulation at 10% and 15% (w/w); (b) the compacting agent (CSD) added at 10% and 15% (w/w) and; (c) the diluent (MC) included at 7.33% and 12.46% (w/w). The analysis of pharmaceutical performance and the accelerated and long-term stability of the best prototype were also completed. RESULT AND DISCUSSION: The binder, compacting agent and the interaction binder/diluent had a significant impact on breaking force of high-dose P. alliacea tablet. The optimum formula was found to contain 15% (w/w) of CSD, 7.33% (w/w) of MC and 10% (w/w) of PVP. At these conditions, the tablet shows a breaking force of 77.96 N, a friability of 0.39%, a total phenol content of 1.30 mg/tablet and a maximum disintegration time of 6 min. CONCLUSIONS: The use of adequate amounts of PVP, MC and CSD as per the factorial design allowed the preparation of a tablet suitable for administration, despite the inappropriate flow and compressibility properties of the P. alliacea powder.
[Mh] Termos MeSH primário: Anti-Inflamatórios/administração & dosagem
Celulose/administração & dosagem
Excipientes/química
Phytolaccaceae/química
Povidona/administração & dosagem
Dióxido de Silício/administração & dosagem
Comprimidos/administração & dosagem
[Mh] Termos MeSH secundário: Anti-Inflamatórios/química
Anti-Inflamatórios/farmacologia
Celulose/química
Química Farmacêutica
Povidona/química
Pós
Dióxido de Silício/química
Comprimidos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Excipients); 0 (Powders); 0 (Tablets); 7631-86-9 (Silicon Dioxide); 9004-34-6 (Cellulose); FZ989GH94E (Povidone); OP1R32D61U (microcrystalline cellulose)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170802
[St] Status:MEDLINE
[do] DOI:10.1080/03639045.2017.1359621


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[PMID]:27692312
[Au] Autor:Arceo-Medina GN; Rosado-Aguilar JA; Rodríguez-Vivas RI; Borges-Argaez R
[Ad] Endereço:Laboratorio de Parasitología, Facultad de Medicina Veterinaria y Zootecnia, Universidad Autónoma de Yucatán, Carretera Mérida-Xmatkuil Km. 15.5, 97100 Mérida, Yucatán, Mexico.
[Ti] Título:Synergistic action of fatty acids, sulphides and stilbene against acaricide-resistant Rhipicephalus microplus ticks.
[So] Source:Vet Parasitol;228:121-125, 2016 Sep 15.
[Is] ISSN:1873-2550
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Six compounds in a methanolic extract of Petiveria alliacea stem (cis-stilbene; benzyl disulphide; benzyl trisulphide; and methyl esters of hexadecanoic acid, octadecadienoic acid and octadecenoic acid) are known to exercise acaricide activity against cattle tick Rhipicephalus microplus larvae and adults. The synergistic effect of 57 combinations of these six compounds on acaricide activity against R. microplus was evaluated. Larvae immersion tests produced the lethal concentrations needed to kill 50% (LC ) and 99% (LC ) of the population. Adult immersion tests produced rates (%) for mortality, oviposition inhibition and eclosion inhibition. Individually, none of the compounds (1% concentration) exhibited acaricide activity (mortality ≤2.3%). When combined, however, nine mixtures exhibited a synergistic increase in activity, with high mortality rates (≥92%) in larvae. Values for LC ranged from 0.07 to 0.51% and those for LC from 0.66 to 5.16%. Thirty six compound mixtures had no significant activity (mortality ≤30%) against larvae. Two mixtures exhibited synergism against adults, with high rates (≥92%) of oviposition inhibition. The mixtures based on the benzyl disulphide+benzyl trisulphide pairing produced a synergistic effect against acaricide-resistant R. microplus larva and adults, and are therefore the most promising combination for controlling this ubiquitous ectoparasite.
[Mh] Termos MeSH primário: Ácidos Graxos/farmacologia
Phytolaccaceae/química
Rhipicephalus/efeitos dos fármacos
Estilbenos/farmacologia
Sulfetos/farmacologia
[Mh] Termos MeSH secundário: Acaricidas/farmacologia
Animais
Bovinos
Doenças dos Bovinos/tratamento farmacológico
Doenças dos Bovinos/parasitologia
Resistência a Medicamentos
Sinergismo Farmacológico
Quimioterapia Combinada
Feminino
Larva/efeitos dos fármacos
Oviposição/efeitos dos fármacos
Extratos Vegetais/farmacologia
Caules de Planta/química
Infestações por Carrapato/parasitologia
Infestações por Carrapato/prevenção & controle
Infestações por Carrapato/veterinária
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acaricides); 0 (Fatty Acids); 0 (Plant Extracts); 0 (Stilbenes); 0 (Sulfides)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170807
[Lr] Data última revisão:
170807
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161004
[St] Status:MEDLINE


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[PMID]:27105957
[Au] Autor:Murray J; Picking D; Lamm A; McKenzie J; Hartley S; Watson C; Williams L; Lowe H; Delgoda R
[Ad] Endereço:Natural Products Institute, University of the West Indies, Mona, Kingston 7, Jamaica.
[Ti] Título:Significant inhibitory impact of dibenzyl trisulfide and extracts of Petiveria alliacea on the activities of major drug-metabolizing enzymes in vitro: An assessment of the potential for medicinal plant-drug interactions.
[So] Source:Fitoterapia;111:138-46, 2016 Jun.
[Is] ISSN:1873-6971
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Dibenzyl trisulfide (DTS) is the major active ingredient expressed in Petiveria alliacea L., a shrub widely used for a range of conditions, such as, arthritis, asthma and cancer. Given its use alone and concomitantly with prescription medicines, we undertook to investigate its impact on the activities of important drug metabolizing enzymes, the cytochromes P450 (CYP), a key family of enzymes involved in many adverse drug reactions. DTS and seven standardized extracts from the plant were assessed for their impact on the activities of CYPs 1A2, 2C19, 2C9, 2D6 and 3A4 on a fluorometric assay. DTS revealed significant impact against the activities of CYPs 1A2, 2C19 and 3A4 with IC50 values of 1.9, 4.0 and 3.2µM, respectively, which are equivalent to known standard inhibitors of these enzymes (furafylline, and tranylcypromine), and the most potent interaction with CYP1A2 displayed irreversible enzyme kinetics. The root extract, drawn with 96% ethanol (containing 2.4% DTS), displayed IC50 values of 5.6, 3.9 and 4.2µg/mL respectively, against the same isoforms, CYPs 1A2, 2C19 and 3A4. These investigations identify DTS as a valuable CYP inhibitor and P. alliacea as a candidate plant worthy of clinical trials to confirm the conclusions that extracts yielding high DTS may lead to clinically relevant drug interactions, whilst extracts yielding low levels of DTS, such as aqueous extracts, are unlikely to cause adverse herb-drug interactions.
[Mh] Termos MeSH primário: Compostos de Benzil/farmacologia
Inibidores das Enzimas do Citocromo P-450/farmacologia
Interações Ervas-Drogas
Phytolaccaceae/química
Extratos Vegetais/farmacologia
Sulfetos/farmacologia
[Mh] Termos MeSH secundário: Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Benzyl Compounds); 0 (Cytochrome P-450 Enzyme Inhibitors); 0 (Plant Extracts); 0 (Sulfides); 0 (dibenzyl trisulfide)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170117
[Lr] Data última revisão:
170117
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160424
[St] Status:MEDLINE


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[PMID]:26945980
[Au] Autor:Arunachalam K; Ascêncio SD; Soares IM; Souza Aguiar RW; da Silva LI; de Oliveira RG; Balogun SO; de Oliveira Martins DT
[Ad] Endereço:Department of Basic Sciences in Health, Faculty of Medicine, Federal University of Mato Grosso (UFMT), Av. Fernando Correa da Costa, no. 2367, Coxipó, Cuiabá, Mato Grosso 78060-900, Brazil.
[Ti] Título:Gallesia integrifolia (Spreng.) Harms: In vitro and in vivo antibacterial activities and mode of action.
[So] Source:J Ethnopharmacol;184:128-37, 2016 May 26.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:ETHNOPHARMACOLOGICAL RELEVANCE: Gallesia integrifolia (Phytolaccaceae) is commonly known as "pau-d'alho" in Brazil or "garlic plant" due to the strong scent of garlic peculiar to all parts of the plant. The bark decoction is used for the treatment of microbial infections among other diseases by different ethnic groups in Brazil, Peruvian Amazonians, Bolivia and Mosetene Indians. This study aimed to advance in the antibacterial activity and characterize the mode of action of the hydroethanolic extract of the inner stem bark of G. integrifolia (HEGi) using in vivo and in vitro experimental models. MATERIALS AND METHODS: The qualitative and quantitative phytochemical analyzes of HEGi were carried out using colorimetric and HPLC technique. The cytotoxic potential of HEGi was evaluated against CHO-K1 cells by Alamar blue assay and its acute toxicity was assessed by the Hippocratic screening test using Swiss-Webster mice. The antibacterial activity was evaluated by micro- dilution method against ten strains of Gram-positive and Gram-negative bacteria. The mode of action of HEGi was investigated by outer membrane permeability, nucleotide leakage and potassium efflux assays. In vivo infection model was established by using Staphylococcus aureus infection model Wistar rats. RESULTS: Qualitative phytochemical analysis of HEGi revealed the presence of saponins, alkaloids, phenolic compounds and flavonoids. Phytochemical quantification of HEGi showed that higher total phenolic (80.10±0.62mg GAE/g) and flavonoid (16.10±0.03mg RE/g) contents. HPLC fingerprint analysis revealed the presence of gallic acid, rutin, and morin. In the Alamar blue assay no cytotoxic effect of HEGi in CHO-K1 cells was observed up to 200µg/mL, and no signs or symptoms of acute toxicity were observed in mice of both sexes at higher doses of up to 2000mg/kg, p.o. HEGi demonstrated bacteriostatic effect against selected Gram positive and Gram negative bacterial pathogens. Its mode of action is associated, at least partly, with changes in the permeability of bacterial membranes, evidenced by the increased entry of hydrophobic antibiotic in Pseudomonas aeruginosa, intense K(+) efflux and nucleotides leakage in Shigella flexneri, Streptococcus pyogenes and S. aureus. HEGi attenuated the experimental blood borne S. aureus infection in rats at all the tested doses levels (10, 50 and 250mg/kg). CONCLUSION: HEGi is safe at the dose tested when used acutely, and it presented broad antibacterial effect, which support its traditional use in the treatment of bacterial infections. It contains well known important phytochemicals, recognized to be active against bacterial pathogens in vitro and might be collectively responsible for the antibacterial activity of HEGi. It is bacteriostatic in nature, with membrane perturbation being one of it mode of action. HEGi represent a potential phytotherapic antibacterial agent.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Antibacterianos/uso terapêutico
Phytolaccaceae
Extratos Vegetais/farmacologia
Extratos Vegetais/uso terapêutico
Infecções Estafilocócicas/tratamento farmacológico
[Mh] Termos MeSH secundário: Animais
Comportamento Animal/efeitos dos fármacos
Células CHO
Sobrevivência Celular/efeitos dos fármacos
Cricetulus
Feminino
Bactérias Gram-Negativas/efeitos dos fármacos
Bactérias Gram-Negativas/crescimento & desenvolvimento
Bactérias Gram-Positivas/efeitos dos fármacos
Bactérias Gram-Positivas/crescimento & desenvolvimento
Masculino
Camundongos
Testes de Sensibilidade Microbiana
Fitoterapia
Casca de Planta
Ratos Wistar
Infecções Estafilocócicas/microbiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Plant Extracts)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170106
[Lr] Data última revisão:
170106
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160307
[St] Status:MEDLINE


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[PMID]:26944236
[Au] Autor:Luz DA; Pinheiro AM; Silva ML; Monteiro MC; Prediger RD; Ferraz Maia CS; Fontes-Júnior EA
[Ad] Endereço:Faculdade de Farmácia, Instituto de Ciências da Saúde, Universidade Federal do Pará, Belém 66075-900, Pará, Brazil; Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Pará, Belém 66075-900, Pará, Brazil.
[Ti] Título:Ethnobotany, phytochemistry and neuropharmacological effects of Petiveria alliacea L. (Phytolaccaceae): A review.
[So] Source:J Ethnopharmacol;185:182-201, 2016 Jun 05.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:ETHNOPHARMACOLOGICAL RELEVANCE: Petiveria alliacea L. commonly grows in the tropical regions of the Americas such as the Amazon forest, Central America, Caribbean islands and Mexico, as well as specific regions of Africa. Popularly known by several different names including 'mucuracaá', 'guiné' and 'pipi', P. alliacea has been used in traditional medicine for the treatment of various central nervous system (CNS) disorders, such as anxiety, pain, memory deficits and seizures, as well as for its anaesthetic and sedative properties. Furthermore, the use of this species for religious ceremonies has been reported since the era of slavery in the Americas. Therefore, the present review aims to provide a critical and comprehensive overview of the ethnobotany, phytochemistry and pharmacological properties of P. alliacea, focusing on CNS pharmacological effects, in order to identify scientific lacunae and to open new perspectives for future research. MATERIALS AND METHODS: A literature search was performed on P. alliacea using ethnobotanical textbooks, published articles in peer-reviewed journals, unpublished materials, government survey reports and scientific databases such as PubMed, Scopus, Web of Science, Science Direct and Google Scholar. The Plant List, International Plant Name Index and Kew Botanical Garden Plant name databases were used to validate the scientific names. RESULTS AND DISCUSSION: Crude extracts, fractions and phytochemical constituents isolated from various parts of P. alliacea show a wide spectrum of neuropharmacological activities including anxiolytic, antidepressant, antinociceptive and anti-seizure, and as cognitive enhancers. Phytochemistry studies of P. alliacea indicate that this plant contains a diversity of biologically active compounds, with qualitative and quantitative variations of the major compounds depending on the region of collection and the harvest season, such as essential oil (Petiverina), saponinic glycosides, isoarborinol-triterpene, isoarborinol-acetate, isoarborinol-cinnamate, steroids, alkaloids, flavonoids and tannins. Root chemical analyses have revealed coumarins, benzyl-hydroxy-ethyl-trisulphide, benzaldehyde, benzoic acid, dibenzyl trisulphide, potassium nitrate, b-sitosterol, isoarborinol, isoarborinol-acetate, isoarborinol-cinnamate, polyphenols, trithiolaniacine, glucose and glycine. CONCLUSIONS: Many traditional uses of P. alliacea have now been validated by modern pharmacology research. The available data reviewed here support the emergence of P. alliacea as a potential source for the treatment of different CNS disorders including anxiety, depression, pain, epilepsy and memory impairments. However, further studies are certainly required to improve the knowledge about the mechanisms of action, toxicity and efficacy of the plant as well as about its bioactive compounds before it can be approved in terms of its safety for therapeutic applications.
[Mh] Termos MeSH primário: Sistema Nervoso Central/efeitos dos fármacos
Etnobotânica
Compostos Fitoquímicos/química
Phytolaccaceae/química
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Extratos Vegetais/química
Plantas Medicinais
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Phytochemicals); 0 (Plant Extracts)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:170224
[Lr] Data última revisão:
170224
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160306
[St] Status:MEDLINE


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[PMID]:25942389
[Au] Autor:Galarraga Montes E; Amaro-Luis JM
[Ad] Endereço:a Departamento de Química, Edificio de Química y Procesos , Universidad Simón Bolívar (USB) , Apartado 89000, Caracas 1080A , Venezuela.
[Ti] Título:Icosandrin, a novel peltogynoid from the fruits of Phytolacca icosandra (Phytolaccaceae).
[So] Source:Nat Prod Res;30(1):89-94, 2016.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Besides the known compounds ( ± ) 3,3-bis-demethylpinoresinol (2), americanol A (3), spergulagenic acid (4), epi-acetylaleuritolic acid (5), 6'-palmityl-α-spinateryl-d-glucoside (6a) and 6'-palmityl-δ(7)-stigmastenyl-d-glucoside (6b), a novel peltogynoid (1) named icosandrin was obtained from the dried fruits of Phytolacca icosandra. This new compound was characterised by 1D-/2D-NMR, UV, IR and HR-MS techniques as 11ξ-methoxy-6,7-methylenedioxy-[2]benzopyrano-[4,3-b][1]-benzopyran-4-one. Toxicity of 1 was assessed through the Brine Shrimp Lethality Assay. Lignan 2 is reported for the first time in Phytolaccaceae family.
[Mh] Termos MeSH primário: Cromonas/química
Compostos Heterocíclicos de 4 ou mais Anéis/química
Phytolacca
[Mh] Termos MeSH secundário: Animais
Artemia
Benzopiranos
Classificação
Frutas/química
Espectroscopia de Ressonância Magnética
Espectrometria de Massas
Phytolacca/química
Phytolacca/classificação
Phytolaccaceae
Extratos Vegetais/química
Espectrofotometria Infravermelho
Espectrofotometria Ultravioleta
Triterpenos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Benzopyrans); 0 (Chromones); 0 (Heterocyclic Compounds, 4 or More Rings); 0 (Plant Extracts); 0 (Triterpenes); 0 (benzopyran-4-one); 28937-85-1 (acetylaleuritolic acid)
[Em] Mês de entrada:1607
[Cu] Atualização por classe:161126
[Lr] Data última revisão:
161126
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150506
[St] Status:MEDLINE
[do] DOI:10.1080/14786419.2015.1038537


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[PMID]:25895883
[Au] Autor:Silva ML; Luz DA; Paixão TP; Silva JP; Belém-Filho IJ; Fernandes LM; Gonçalves AC; Fontes-Júnior EA; de Andrade MA; Maia CS
[Ad] Endereço:Faculdade de Farmácia, Instituto de Ciências da Saúde, Universidade Federal do Pará, 66075-900 Belém, Pará, Brazil.
[Ti] Título:Petiveria alliacea exerts mnemonic and learning effects on rats.
[So] Source:J Ethnopharmacol;169:124-9, 2015 Jul 01.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:ETHNOPHARMACOLOGICAL RELEVANCE: Petiveria alliacea L. (Phytolaccaceae) is a perennial shrub native to the Amazon region and other tropical areas such as Central America and the Caribbean. Popularly known as mucuracaá, P. alliacea is used in the folk medicine for a broad variety of therapeutic purpose and also in religious ceremonies by slaves as a sedative, which highlights its properties on the Central Nervous System (CNS). AIM OF THE STUDY: The present study evaluated the effects of the P. alliacea leaves hydroalcoholic extract (PaLHE) on the cognition, including learning and memory. MATERIAL AND METHODS: Three-month-old male and female Wistar rats (n=8-10/group) were administered with 900mg/kg of PaLHE. The behavioral assays included Step-down Inhibitory avoidance (IA) and Morris Water Maze (MWM) tests. RESULTS: Consistent with our previous reports, P. alliacea improved long-term memory. It also exerted previously unreported effects on short-term and spatial memory improvement, and increased learning in the tasks. CONCLUSIONS: The P. alliacea extract elicited mnemonic effects and improved the learning process in both IA and MWM tests. Our results highlight the importance of further studies in order to identify the active substances of the PaLHE and investigate the pharmacological mechanisms that underlies the reported effects.
[Mh] Termos MeSH primário: Aprendizagem da Esquiva/efeitos dos fármacos
Aprendizagem em Labirinto/efeitos dos fármacos
Phytolaccaceae
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Animais
Aprendizagem da Esquiva/fisiologia
Feminino
Masculino
Aprendizagem em Labirinto/fisiologia
Extratos Vegetais/isolamento & purificação
Folhas de Planta
Ratos
Ratos Wistar
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Plant Extracts)
[Em] Mês de entrada:1602
[Cu] Atualização por classe:150608
[Lr] Data última revisão:
150608
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150422
[St] Status:MEDLINE


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[PMID]:25080754
[Ti] Título:Inhibition of oral biofilm and cell-cell communication using natural-products derivatives.
[So] Source:J Calif Dent Assoc;42(6):369, 2014 Jun.
[Is] ISSN:1043-2256
[Cp] País de publicação:United States
[La] Idioma:eng
[Mh] Termos MeSH primário: Antibacterianos/uso terapêutico
Biofilmes/efeitos dos fármacos
Bactérias Gram-Positivas/efeitos dos fármacos
Boca/microbiologia
Preparações de Plantas/uso terapêutico
[Mh] Termos MeSH secundário: Cisteína/análogos & derivados
Seres Humanos
Phytolaccaceae
Percepção de Quorum/efeitos dos fármacos
[Pt] Tipo de publicação:NEWS
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Plant Preparations); K848JZ4886 (Cysteine)
[Em] Mês de entrada:1408
[Cu] Atualização por classe:140801
[Lr] Data última revisão:
140801
[Sb] Subgrupo de revista:D
[Da] Data de entrada para processamento:140802
[St] Status:MEDLINE


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[PMID]:24637191
[Au] Autor:Hernández JF; Urueña CP; Cifuentes MC; Sandoval TA; Pombo LM; Castañeda D; Asea A; Fiorentino S
[Ad] Endereço:Grupo de Inmunobiología y Biología Celular, Facultad de Ciencias, Pontificia Universidad Javeriana, Carrera 7 N. 43-82 Building 52, Office 608, Bogotá, Colombia.
[Ti] Título:A Petiveria alliacea standardized fraction induces breast adenocarcinoma cell death by modulating glycolytic metabolism.
[So] Source:J Ethnopharmacol;153(3):641-9, 2014 May 14.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:ETHNOPHARMACOLOGICAL RELEVANCE: Folk medicine uses aqueous and alcoholic extracts from Petiveria alliacea (Phytolaccaceae) in leukemia and breast cancer treatment in the Caribbean, Central and South America. Herein, we validated the biological activity of a Petiveria alliacea fraction using a metastatic breast adenocarcinoma model (4T1). MATERIALS AND METHODS: Petiveria alliacea fraction biological activity was determined estimating cell proliferation, cell colony growth capacity and apoptosis (caspase-3 activity, DNA fragmentation and mitochondrial membrane potential) in 4T1 cells. Petiveria alliacea was used at IC50 concentration (29 µg/mL) and 2 dilutions below, doxorubicin at 0.27 µg/mL (positive control) and dibenzyl disulfide at 2.93 µg/mL (IC50 fraction marker compound). Proteomic estimations were analyzed by LC-MS-MS. Protein level expression was confirmed by RT-PCR. Glucose and lactate levels were measured by enzymatic assays. LD50 was established in BALB/c mice and antitumoral activity evaluated in mice transplanted with GFP-tagged 4T1 cells. Mice were treated with Petiveria alliacea fraction via I.P (182 mg/kg corresponding to 1/8 of LD50 and 2 dilutions below). RESULTS: Petiveria alliacea fraction in vitro induces 4T1 cells apoptosis, caspase-3 activation, DNA fragmentation without mitochondria membrane depolarization, and decreases cell colony growth capacity. Also, changes in glycolytic enzymes expression cause a decrease in glucose uptake and lactate production. Fraction also promotes breast primary tumor regression in BALB/c mice transplanted with GFP-tagged 4T1 cells. CONCLUSION: A fraction of Petiveria alliacea leaves and stems induces in vitro cell death and in vivo tumor regression in a murine breast cancer model. Our results validate in partly, the traditional use of Petiveria alliacea in breast cancer treatment, revealing a new way of envisioning Petiveria alliacea biological activity. The fraction effect on the glycolytic pathway enzymes contributes to explain the antiproliferative and antitumor activities.
[Mh] Termos MeSH primário: Adenocarcinoma/tratamento farmacológico
Antineoplásicos
Neoplasias da Mama/tratamento farmacológico
Phytolaccaceae
Extratos Vegetais
[Mh] Termos MeSH secundário: Animais
Antineoplásicos/farmacologia
Antineoplásicos/uso terapêutico
Caspase 3/metabolismo
Morte Celular/efeitos dos fármacos
Linhagem Celular Tumoral
Fragmentação do DNA
Feminino
Glicólise/efeitos dos fármacos
Potencial da Membrana Mitocondrial/efeitos dos fármacos
Camundongos
Camundongos Endogâmicos BALB C
Fitoterapia
Extratos Vegetais/farmacologia
Extratos Vegetais/uso terapêutico
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Plant Extracts); EC 3.4.22.- (Caspase 3)
[Em] Mês de entrada:1501
[Cu] Atualização por classe:140512
[Lr] Data última revisão:
140512
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140319
[St] Status:MEDLINE


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[PMID]:24051024
[Au] Autor:Silva Júnior Ade J; de Campos-Buzzi F; Romanos MT; Wagner TM; Guimarães AF; Filho VC; Batista R
[Ad] Endereço:Departamento de Estudos Básicos e Instrumentais, Universidade Estadual do Sudoeste da Bahia, 45700-000 Itapetinga, BA, Brazil.
[Ti] Título:Chemical composition and antinociceptive, anti-inflammatory and antiviral activities of Gallesia gorazema (Phytolaccaceae), a potential candidate for novel anti-herpetic phytomedicines.
[So] Source:J Ethnopharmacol;150(2):595-600, 2013 Nov 25.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:ETHNOPHARMACOLOGICAL RELEVANCE: In traditional medicine, teas made from leaves and bark of Gallesia gorazema are used as antispasmodic, anthelmintic, antihemorrhagic and febrifuge agents. Crude leaves of this plant are also employed as a remedy in the treatment of abscesses, orchitis, gonorrhea and for rheumatic pain relief. this study investigates the presumed antinociceptive and anti-inflammatory activities of leaves and roots Gallesia gorazema (Phytolaccaceae) extracts. The most active extract and its isolated compound, a new natural product, are also evaluated against viruses HSV-1 and HSV-2. MATERIALS AND METHODS: In vivo experiments with mice were used to assess the analgesic and anti-inflammatory activities of Gallesia gorazema extracts. Antiviral activity of extracts and the new natural product was investigated by in vitro experiments. RESULTS: Results show that dichloromethanic root (DRE) and ethanolic leaf (ELE) extracts displayed significant antinociceptive and anti-inflammatory activities in in vivo experiments with mice. Both extracts were also assayed against the herpes simplex viruses HSV-1 and HSV-2, but only DRE was highly active, showing a selective antiviral effect against HSV-1. Phytochemical fractionation of DRE led to the isolation of 28-hydroxyoctacosyl ferulate, a novel natural product, which displayed strong antiviral activity against HSV-1 (EC50=21.6 µg/mL) with a selective index above 9, justifying, at least in part, the high selective antiviral activity observed for DRE. CONCLUSION: These results suggest that the plant Gallesia gorazema is a potential candidate for the development of novel anti-herpetic phytomedicines.
[Mh] Termos MeSH primário: Analgésicos/farmacologia
Anti-Inflamatórios/farmacologia
Antivirais/farmacologia
Phytolaccaceae
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Ácido Acético
Analgésicos/uso terapêutico
Animais
Anti-Inflamatórios/química
Anti-Inflamatórios/uso terapêutico
Antivirais/química
Antivirais/uso terapêutico
Cercopithecus aethiops
Formaldeído
Ácido Glutâmico
Herpesvirus Humano 1/efeitos dos fármacos
Herpesvirus Humano 1/genética
Herpesvirus Humano 2/efeitos dos fármacos
Herpesvirus Humano 2/genética
Camundongos
Dor/induzido quimicamente
Dor/tratamento farmacológico
Extratos Vegetais/química
Extratos Vegetais/uso terapêutico
Folhas de Planta
Raízes de Plantas
Células Vero
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Analgesics); 0 (Anti-Inflammatory Agents); 0 (Antiviral Agents); 0 (Plant Extracts); 1HG84L3525 (Formaldehyde); 3KX376GY7L (Glutamic Acid); Q40Q9N063P (Acetic Acid)
[Em] Mês de entrada:1406
[Cu] Atualização por classe:131111
[Lr] Data última revisão:
131111
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130921
[St] Status:MEDLINE



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