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[PMID]:28319742
[Au] Autor:Wang S; Gao B; Li Y; Ok YS; Shen C; Xue S
[Ad] Endereço:School of Environmental Science and Engineering, Yangzhou University, Yangzhou 225009, China; Department of Agricultural and Biological Engineering, University of Florida, Gainesville, FL 32611, USA.
[Ti] Título:Biochar provides a safe and value-added solution for hyperaccumulating plant disposal: A case study of Phytolacca acinosa Roxb. (Phytolaccaceae).
[So] Source:Chemosphere;178:59-64, 2017 Jul.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:In this work, an innovative approach using biochar technology for hyperaccumulator disposal was developed and evaluated. The heavy metal enriched P. acinosa biomass (PBM) was pyrolyzed to produce biochar (PBC). Both PBM and PBC were characterized with X-ray diffraction (XRD) for crystal phases, scanning electron microscopy (SEM) for surface topography, and analyzed for elemental composition and mobility. The results revealed that whewellite, a dominant crystal form in biomass, was decomposed to calcite after pyrolysis. Elemental analysis indicated that 91-99% total non-volatile elements in the biomass were retained in the biochar. The toxicity characteristic leaching procedure (TCLP) results revealed that 94.6% and 0.15% of total Mn was extracted for biomass and biochar, respectively. This suggests that mobility and bioavailability of Mn in biochar was much lower relative to pristine biomass. Batch sorption experiment showed that excellent removal of aqueous silver, lead, cadmium, and copper ions can be achieved with PBC. Findings from this work indicated that biochar technology can provide a value-added solution for hyperaccumulator disposal.
[Mh] Termos MeSH primário: Biomassa
Carvão Vegetal/síntese química
Recuperação e Remediação Ambiental/métodos
Phytolacca
[Mh] Termos MeSH secundário: Carbonato de Cálcio/síntese química
Incineração
Metais Pesados/isolamento & purificação
Phytolacca/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Metals, Heavy); 0 (biochar); 16291-96-6 (Charcoal); H0G9379FGK (Calcium Carbonate)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170524
[Lr] Data última revisão:
170524
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170321
[St] Status:MEDLINE


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[PMID]:28193591
[Au] Autor:Huang X; Tang K; Xu X; Cai C
[Ad] Endereço:College of Life Science, Fujian Normal University, Fuzhou 350108, China; Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou 350001, China.
[Ti] Título:Interaction of Fe-Mn plaque and Arthrobacter echigonensis MN1405 and uptake and translocation of Cd by Phytolacca acinosa Roxb.
[So] Source:Chemosphere;174:585-592, 2017 May.
[Is] ISSN:1879-1298
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:In this study, hydroponic experiments were conducted to investigate the role of Fe-Mn plaque and Arthrobacter echigonensis MN1405 under different solution Cd levels (0, 2 and 50 mg L ) on Cd uptake and translocation by Phytolacca acinosa Roxb. (P. acinosa). Results showed Cd accumulated by P.acinosa without plaque were mostly distributed in root surface, indicating that an exclusion strategy for Cd tolerance. The formation of Fe-Mn plaque could contribute to the increase in the Cd tolerance of P.acinosa, promotion of the growth, increase in the enhancement of Cd translocation. Among all the treatments, Fe-Mn plaque treatments inoculated with MN1405 accumulated the maximum DCB-Cd (46.61 ± 6.36 g kg ) and had the highest value of TF (2.14 ± 0.01) at 50 mg L and 2 mg L solution for Cd, respectively, demonstrating the greatest capacity to accumulate and translocate Cd. The uptake of Cd by P. acinosa in plaque treatments may result in the increase of soluble sugar and decrease of soluble protein synthesized from roots which involved in Cd detoxification and thus diminished the negative effects of Cd to some extent.
[Mh] Termos MeSH primário: Cádmio/metabolismo
Ferro/metabolismo
Phytolacca/metabolismo
[Mh] Termos MeSH secundário: Arthrobacter/metabolismo
Hidroponia
Raízes de Plantas/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
00BH33GNGH (Cadmium); E1UOL152H7 (Iron)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170512
[Lr] Data última revisão:
170512
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170215
[St] Status:MEDLINE


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[PMID]:27159623
[Au] Autor:Li F; Tang K; Cai C; Xu X
[Ad] Endereço:a College of Life Sciences, Fujian Normal University , Fuzhou , Fujian Province , China.
[Ti] Título:Phytolacca acinosa Roxb. with Arthrobacter echigonensis MN1405 enhances heavy metal phytoremediation.
[So] Source:Int J Phytoremediation;18(10):956-65, 2016 Oct 02.
[Is] ISSN:1549-7879
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The growth and metal-extraction efficiency of plants when exposed to toxic metals can be enhanced by inoculating with certain bacteria, but the mechanisms of this process remain unclear. We report results from glasshouse experiments on the effect of Arthrobacter echigonensis MN1405 in promoting Phytolacca acinosa Roxb. growth when exposed to 100 mg/L Mn solution. Mn removal efficiency in solution was significantly enhanced by bacterial inoculation; Mn was accumulated in the root of P. acinosa Roxb. plant. The bacteria oxidized the Mn on root surface, which formed a Mn plaque to serve as a barrier or a containment to prevent metal toxicity. In this process, pH condition was an important factor on the effects of microbial-assisted heavy metal phytoremediation. Our finding suggests that A. echigonensis MN1405 assisted P. acinosa to achieve high remediation efficiency of Mn removal and accumulation in Mn contamination area.
[Mh] Termos MeSH primário: Arthrobacter/fisiologia
Biodegradação Ambiental
Manganês/metabolismo
Phytolacca/fisiologia
Poluentes do Solo/metabolismo
[Mh] Termos MeSH secundário: Phytolacca/crescimento & desenvolvimento
Phytolacca/microbiologia
Raízes de Plantas/crescimento & desenvolvimento
Raízes de Plantas/microbiologia
Raízes de Plantas/fisiologia
Simbiose
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Soil Pollutants); 42Z2K6ZL8P (Manganese)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170406
[Lr] Data última revisão:
170406
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160510
[St] Status:MEDLINE
[do] DOI:10.1080/15226514.2016.1183573


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[PMID]:26971856
[Au] Autor:Iglesias R; Citores L; Ragucci S; Russo R; Di Maro A; Ferreras JM
[Ad] Endereço:Department of Biochemistry and Molecular Biology and Physiology, Faculty of Sciences, University of Valladolid, E-47011 Valladolid, Spain.
[Ti] Título:Biological and antipathogenic activities of ribosome-inactivating proteins from Phytolacca dioica L.
[So] Source:Biochim Biophys Acta;1860(6):1256-64, 2016 Jun.
[Is] ISSN:0006-3002
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The species from the genus Phytolacca constitute one of the best sources of ribosome-inactivating proteins (RIPs) that have been used both in the therapy against virus and tumors and in the construction of transgenic plants resistant to virus, bacteria, fungi and insects. Here we investigate new activities of three representative RIPs from Phytolacca dioica (dioicin 2, PD-S2 and PD-L4). RESULTS: The three RIPs displayed, in addition to already reported activities, rRNA N-glycosylase activities against plant, bacterial and fungal ribosomes. Additionally dioicin 2 and PD-L4 displayed endonuclease activity on a supercoiled plasmid DNA, and dioicin 2 and PD-S2 arrested the growth of the fungus Penicillium digitatum. Furthermore, dioicin 2 induced caspase activation and apoptosis in cell cultures. CONCLUSIONS: The different activities of the RIPs from Phytolacca dioica may explain the antipathogenic properties attributed to these RIPs in plants and their antiviral and antitumoral effects. In spite of the similarity in their rRNA N-glycosylase and DNA polynucleotide:adenosine glycosylase activities, they differed in their activities against viral RNA, plasmid DNA, fungi and animal cultured cells. This suggests that the presence of isoforms might optimize the response of the plant against several types of pathogens. GENERAL SIGNIFICANCE: RIPs from Phytolacca can induce plant resistance or tumor cell death not only by means of ribosome inactivation but also by the activities found in this report. Furthermore, the induction of cell death by different mechanisms turns these RIPs into more useful tools for cancer treatment rendering the selection of RIP-resistant mutants impossible.
[Mh] Termos MeSH primário: Phytolacca/química
Proteínas Inativadoras de Ribossomos/farmacologia
[Mh] Termos MeSH secundário: Sequência de Aminoácidos
Endonucleases/metabolismo
Dados de Sequência Molecular
Penicillium/efeitos dos fármacos
Inibidores da Síntese de Proteínas/farmacologia
Proteínas Inativadoras de Ribossomos/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Protein Synthesis Inhibitors); EC 3.1.- (Endonucleases); EC 3.2.2.22 (Ribosome Inactivating Proteins)
[Em] Mês de entrada:1608
[Cu] Atualização por classe:161126
[Lr] Data última revisão:
161126
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160315
[St] Status:MEDLINE


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[PMID]:25942389
[Au] Autor:Galarraga Montes E; Amaro-Luis JM
[Ad] Endereço:a Departamento de Química, Edificio de Química y Procesos , Universidad Simón Bolívar (USB) , Apartado 89000, Caracas 1080A , Venezuela.
[Ti] Título:Icosandrin, a novel peltogynoid from the fruits of Phytolacca icosandra (Phytolaccaceae).
[So] Source:Nat Prod Res;30(1):89-94, 2016.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Besides the known compounds ( ± ) 3,3-bis-demethylpinoresinol (2), americanol A (3), spergulagenic acid (4), epi-acetylaleuritolic acid (5), 6'-palmityl-α-spinateryl-d-glucoside (6a) and 6'-palmityl-δ(7)-stigmastenyl-d-glucoside (6b), a novel peltogynoid (1) named icosandrin was obtained from the dried fruits of Phytolacca icosandra. This new compound was characterised by 1D-/2D-NMR, UV, IR and HR-MS techniques as 11ξ-methoxy-6,7-methylenedioxy-[2]benzopyrano-[4,3-b][1]-benzopyran-4-one. Toxicity of 1 was assessed through the Brine Shrimp Lethality Assay. Lignan 2 is reported for the first time in Phytolaccaceae family.
[Mh] Termos MeSH primário: Cromonas/química
Compostos Heterocíclicos de 4 ou mais Anéis/química
Phytolacca
[Mh] Termos MeSH secundário: Animais
Artemia
Benzopiranos
Classificação
Frutas/química
Espectroscopia de Ressonância Magnética
Espectrometria de Massas
Phytolacca/química
Phytolacca/classificação
Phytolaccaceae
Extratos Vegetais/química
Espectrofotometria Infravermelho
Espectrofotometria Ultravioleta
Triterpenos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Benzopyrans); 0 (Chromones); 0 (Heterocyclic Compounds, 4 or More Rings); 0 (Plant Extracts); 0 (Triterpenes); 0 (benzopyran-4-one); 28937-85-1 (acetylaleuritolic acid)
[Em] Mês de entrada:1607
[Cu] Atualização por classe:161126
[Lr] Data última revisão:
161126
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150506
[St] Status:MEDLINE
[do] DOI:10.1080/14786419.2015.1038537


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[PMID]:26297825
[Au] Autor:Pizzo E; Zanfardino A; Di Giuseppe AM; Bosso A; Landi N; Ragucci S; Varcamonti M; Notomista E; Di Maro A
[Ad] Endereço:Department of Biology, University of Naples "Federico II" Via Cintia, I-80126 Napoli, Italy. Electronic address: eliodoro.pizzo@unina.it.
[Ti] Título:A new active antimicrobial peptide from PD-L4, a type 1 ribosome inactivating protein of Phytolacca dioica L.: A new function of RIPs for plant defence?
[So] Source:FEBS Lett;589(19 Pt B):2812-8, 2015 Sep 14.
[Is] ISSN:1873-3468
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:We investigated the antimicrobial activity of PD-L4, a type 1 RIP from Phytolacca dioica. We found that this protein is active on different bacterial strains both in a native and denatured/alkylated form and that this biological activity is related to a cryptic peptide, named PDL440-65, identified by chemical fragmentation. This peptide showed the same antimicrobial activity of full-length protein and possessed, similarly to several antimicrobial peptides, an immunomodulatory effect on human cells. It assumes an alpha-helical conformation when interact with mimic membrane agents as TFE and likely bacterial membranes are a target of this peptide. To date PDL440-65 is the first antimicrobial peptide identified in a type 1 RIP.
[Mh] Termos MeSH primário: Anti-Infecciosos/farmacologia
Fragmentos de Peptídeos/farmacologia
Phytolacca/fisiologia
Proteínas de Plantas/metabolismo
Proteínas Inativadoras de Ribossomos/metabolismo
[Mh] Termos MeSH secundário: Sequência de Aminoácidos
Anti-Infecciosos/química
Anti-Infecciosos/toxicidade
Bactérias/efeitos dos fármacos
Células CACO-2
Seres Humanos
Dados de Sequência Molecular
Fragmentos de Peptídeos/química
Fragmentos de Peptídeos/toxicidade
Phytolacca/química
Folhas de Planta/química
Proteínas de Plantas/química
Conformação Proteica
Proteínas Inativadoras de Ribossomos/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Infective Agents); 0 (Peptide Fragments); 0 (Plant Proteins); EC 3.2.2.22 (Ribosome Inactivating Proteins)
[Em] Mês de entrada:1512
[Cu] Atualização por classe:150914
[Lr] Data última revisão:
150914
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150823
[St] Status:MEDLINE


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[PMID]:26049105
[Au] Autor:Russo R; Chambery A; Severino V; Parente A; Di Maro A
[Ad] Endereço:Department of Environmental, Biological and Pharmaceutical Sciences and Technologies, Second University of Naples, Via Vivaldi 43, I-81100 Caserta, Italy.
[Ti] Título:Structural characterization of dioicin 1 from Phytolacca dioica L. gains novel insights into phylogenetic relationships of Phytolaccaceae type 1 RIPs.
[So] Source:Biochem Biophys Res Commun;463(4):732-8, 2015 Aug 07.
[Is] ISSN:1090-2104
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Ribosome-inactivating proteins are plant cytotoxic enzymes, also present in fungi, algae and bacteria, mainly known for their ability to inhibit protein synthesis. We previously purified and structurally characterized three type 1 RIPs (PD-S1-3) from Phytolacca dioica seeds and four type 1 RIPs (PD-L1-4) from adult plant leaves. Two additional RIPs, named dioicin 1 and dioicin 2, were isolated from leaves of young plants and developing leaves of adult plants. The evidence that P. dioica synthesizes and accumulates these RIPs isoforms suggests that these proteins have been conserved during evolution. Though several aspects of P. dioica type 1 RIP characterization have been studied, some important questions remain to be answered especially with respect to Phytolaccaceae RIP evolution. One of the major problems encountered in approaching RIPs phylogeny concerns the availability of their sequences. In this study, we report the characterization of biological and structural properties of dioicin 1, including the determination of its primary structure by using a combined approach based on Edman degradation, de novo sequencing by ESI-Q-TOF-MS/MS and peptide mapping by MALDI-TOF MS. Knowledge of dioicin 1 primary structure provide us a mean to deepen Phytolaccaceae's RIPs phylogeny. We speculate that both dioicins 1 and 2 share common ancestors with PAP-II and PAP icos-II and that dioicin 1 is not closely related to other members of this clade, thus shedding lights on evolutionary relationships among type 1 RIPs from Phytolaccaceae.
[Mh] Termos MeSH primário: Filogenia
Phytolacca/química
Proteínas de Plantas/química
Proteínas Inativadoras de Ribossomos Tipo 1/química
[Mh] Termos MeSH secundário: Sequência de Aminoácidos
Dicroísmo Circular
Espectrometria de Massas
Dados de Sequência Molecular
Proteínas Inativadoras de Ribossomos Tipo 1/classificação
Homologia de Sequência de Aminoácidos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Plant Proteins); 0 (Ribosome Inactivating Proteins, Type 1)
[Em] Mês de entrada:1511
[Cu] Atualização por classe:150708
[Lr] Data última revisão:
150708
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150607
[St] Status:MEDLINE


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[PMID]:23572390
[Au] Autor:Ullah N; Haq IU; Safdar N; Mirza B
[Ad] Endereço:Department of Biochemistry, Quaid-i-Azam University, Islamabad, Pakistan Department of Biotechnology, Abdul Wali khan University, Mardan, Pakistan.
[Ti] Título:Physiological and biochemical mechanisms of allelopathy mediated by the allelochemical extracts of Phytolacca latbenia (Moq.) H. Walter.
[So] Source:Toxicol Ind Health;31(10):931-7, 2015 Oct.
[Is] ISSN:1477-0393
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:In allelopathy, one plant suppresses the growth and development of other plant/plants by negatively affecting a variety of physiological and biochemical reactions. We checked the effects of methanolic extracts (allelochemical extracts) of Phytolacca latbenia (Moq.) H. Walter on antioxidant enzyme activities such as peroxidases (PODs), super oxide dismutases (SODs) and catalase (CAT) and on total protein contents (TPC), cellular injury (CI), and malondialdehyde (MDA) in the germinating seeds of Brassica napus L. (dicot) and Triticum aestivum L. (monocot). Both the crude methanolic extract root (CMER) and crude methanolic extract aerial (CMEA) of P. latbenia at 10000 ppm significantly reduced the POD activity in both the test seeds. The activity of SODs was significantly decreased by both CMER and CMEA in B. napus germinating seeds. A linear increase in the activity of CAT, CI, and MDA contents was found in both the test seeds with the increasing concentrations of CMEA and CMER, while TPC of the germinating seeds was found decreased. It is inferred that both the CMEA and CMER inhibited/delayed the seed germination, reduced the seedling growth by affecting a variety of biochemical and physiological attributes, and also caused cellular membrane injury in the germinating seeds of both the monocot and dicot seeds.
[Mh] Termos MeSH primário: Antioxidantes
Phytolacca/química
Extratos Vegetais
[Mh] Termos MeSH secundário: Alelopatia
Antioxidantes/química
Antioxidantes/farmacologia
Brassica napus/efeitos dos fármacos
Condutividade Elétrica
Germinação/efeitos dos fármacos
Malondialdeído/metabolismo
Extratos Vegetais/química
Extratos Vegetais/farmacologia
Proteínas de Plantas/análise
Proteínas de Plantas/metabolismo
Sementes/efeitos dos fármacos
Triticum/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Plant Extracts); 0 (Plant Proteins); 4Y8F71G49Q (Malondialdehyde)
[Em] Mês de entrada:1607
[Cu] Atualização por classe:150926
[Lr] Data última revisão:
150926
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130411
[St] Status:MEDLINE
[do] DOI:10.1177/0748233713483205


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[PMID]:23344824
[Au] Autor:Ullah N; Haq IU; Mirza B
[Ad] Endereço:Department of Biotechnology, Abdul Wali Khan University, Mardan, Pakistan.
[Ti] Título:Phytotoxicity evaluation and phytochemical analysis of three medicinally important plants from Pakistan.
[So] Source:Toxicol Ind Health;31(5):389-95, 2015 May.
[Is] ISSN:1477-0393
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:This work examines the crude methanolic extracts of three medicinally important plants native to Pakistan for potent phytotoxic activities and important phytochemicals. These plants include Euphorbia wallichii, Bergenia ciliata and Phytolacca latbenia. The phytotoxic effects were checked at 10,000, 1000, and 100 µg/ml against two economically important standard target species, Triticum aestivum (monocot representative) and Brassica napus (dicot representative). The phytotoxicity effects on seed germination, seedling growth and seedling weight were checked. A simple, cost-effective in vitro phytotoxicity assay (that uses petri plates) was used to evaluate the allelopathic properties of crude extracts. At highest concentration, extracts from all the three plants showed phytotoxic activities such that P. latbenia > E. wallichii > B. ciliata. In seedling growth, root length was affected more than shoot length, whereas among the target species B. napus was found to be more sensitive towards extracts when compared with T. aestivum. Phytochemical analysis showed that P. latbenia is rich in saponins and terpenoids, while E. wallichii and B. ciliata are rich in tannins, terpenoids and cardiac glycoside. P. latbenia also carries a moderate amount of cardiac glycosides.
[Mh] Termos MeSH primário: Compostos Fitoquímicos/toxicidade
Extratos Vegetais/toxicidade
Plantas Medicinais/química
[Mh] Termos MeSH secundário: Brassica napus/efeitos dos fármacos
Relação Dose-Resposta a Droga
Euphorbia/química
Glicosídeos/análise
Metanol/metabolismo
Paquistão
Phytolacca/química
Saponinas/análise
Saxifragaceae/química
Plântulas/efeitos dos fármacos
Taninos/análise
Terpenos/análise
Triticum/efeitos dos fármacos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Glycosides); 0 (Phytochemicals); 0 (Plant Extracts); 0 (Saponins); 0 (Tannins); 0 (Terpenes); Y4S76JWI15 (Methanol)
[Em] Mês de entrada:1602
[Cu] Atualização por classe:150501
[Lr] Data última revisão:
150501
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130125
[St] Status:MEDLINE
[do] DOI:10.1177/0748233712472527


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[PMID]:25242384
[Au] Autor:Niu X; Mu Q; Li W; Yao H; Li H; Li Y; Hu H; Huang H
[Ad] Endereço:School of Pharmacy, Xi'an Jiaotong University, Xi'an 710061, P.R. China. Electronic address: niuxf@mail.xjtu.edu.cn.
[Ti] Título:Protective effects of esculentic acid against endotoxic shock in Kunming mice.
[So] Source:Int Immunopharmacol;23(1):229-35, 2014 Nov.
[Is] ISSN:1878-1705
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Esculentic acid (EA), a triterpene compound extracted from the root of Phytolacca esculenta (the Chinese name Shang Lu), has been widely used to therapy a variety of inflammatory diseases such as rheumatoid arthritis, edema, hepatitis and bronchitis. The present study was designed to investigate the protective effects of EA against LPS-induced endotoxic shock by the intraperitoneal injection of EA (1, 5 and 10 mg/kg) prior to LPS stimulation (1 mg/kg, i.p.). We examined the effects of EA on the survival rate of mice, inflammatory cytokine and pro-inflammatory mediator production, histopathological changes and protein expression of COX-2 in tissue sections from lung, liver and kidney. The results indicate that EA not only increases the survival rate of mice, but decreases the levels of TNF-α, IL-6, NO and PGE2 in serum or tissues, histopathological changes and COX-2 protein expression also. Furthermore, EA also increases the levels of anti-inflammatory cytokine IL-10 in serum. Overall, these data suggest that the protective effects of EA against LPS-induced endotoxic shock may be mediated, at least in part, by regulation the release of inflammatory cytokines and mediators, and protein expression of COX-2 in mice.
[Mh] Termos MeSH primário: Anti-Inflamatórios não Esteroides/uso terapêutico
Ciclo-Oxigenase 2/metabolismo
Fitoterapia/métodos
Choque Séptico/tratamento farmacológico
Triterpenos/uso terapêutico
[Mh] Termos MeSH secundário: Animais
Ciclo-Oxigenase 2/genética
Citocinas/metabolismo
Dinoprostona/sangue
Modelos Animais de Doenças
Regulação para Baixo/efeitos dos fármacos
Seres Humanos
Mediadores da Inflamação/metabolismo
Lipopolissacarídeos/administração & dosagem
Masculino
Camundongos
Camundongos Endogâmicos
Phytolacca/imunologia
Choque Séptico/induzido quimicamente
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents, Non-Steroidal); 0 (Cytokines); 0 (Inflammation Mediators); 0 (Lipopolysaccharides); 0 (Triterpenes); 0 (esculentic acid); EC 1.14.99.1 (Cyclooxygenase 2); K7Q1JQR04M (Dinoprostone)
[Em] Mês de entrada:1508
[Cu] Atualização por classe:150129
[Lr] Data última revisão:
150129
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:140923
[St] Status:MEDLINE



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