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Pesquisa : B01.650.940.800.575.912.250.198.500.875.500.750 [Categoria DeCS]
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[PMID]:27280350
[Au] Autor:Getachew D; Balkew M; Gebre-Michael T
[Ad] Endereço:1 Department of Biology, Dire Dawa University, PO Box 1362, Dire Dawa, Ethiopia.
[Ti] Título:Evaluation of Endod (Phytolacca dodecandra: Phytolaccaceae) as a Larvicide Against Anopheles arabiensis, the Principal Vector of Malaria in Ethiopia.
[So] Source:J Am Mosq Control Assoc;32(2):124-9, 2016 Jun.
[Is] ISSN:8756-971X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Malaria control methods rely mostly on adult mosquito control using insecticide-treated nets and indoor residual spraying with insecticides. Plants such as endod (Phytolacca dodecandra) can potentially be used for the control of mosquito larvae as a supplement to adult control methods. Following the discovery of endod, a molluscicide plant, more than 5 decades ago in Ethiopia, subsequent studies have shown that its potency can further be increased by simple procedures such as aging endod berry powder in water. This study was conducted to evaluate the killing effect of fresh and aged endod solution against 4th-stage larvae of Anopheles arabiensis. Laboratory-reared An. arabiensis larvae exposed to different concentrations of endod preparation using distilled or spring water had 50% lethal concentration (LC(50))  =  49.6 ppm and 90% lethal concentration (LC(90))  =  234 ppm for fresh and LC(50)  =  36.4 ppm and LC(90)  =  115.7 ppm for the aged endod solution in distilled water against the laboratory population. Against field-collected larvae of the same species, aged preparations in habitat water resulted in higher LC(50) (472.7 ppm) and LC(90) (691 ppm) values, with only a slight improvement over fresh preparations in habitat water (LC(50)  =  456.2 ppm; LC(90)  =  896.1 ppm). In general, although aged preparations of endod required lower concentrations than fresh to kill at least 90% of the larvae, these concentrations were much higher (12-70×) than that required for schistosome-transmitting snails.
[Mh] Termos MeSH primário: Anopheles
Inseticidas
Controle de Mosquitos/normas
Phytolacca dodecandra/química
[Mh] Termos MeSH secundário: Animais
Anopheles/crescimento & desenvolvimento
Etiópia
Frutas/química
Larva
Extratos Vegetais/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Insecticides); 0 (Plant Extracts)
[Em] Mês de entrada:1608
[Cu] Atualização por classe:160610
[Lr] Data última revisão:
160610
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160610
[St] Status:MEDLINE
[do] DOI:10.2987/moco-32-02-124-129.1


  2 / 15 MEDLINE  
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[PMID]:24050774
[Au] Autor:Arora S; Aggarwal A; Singla P; Jyoti S; Tandon S
[Ad] Endereço:Jaypee University of Information Technology, Waknaghat, Solan 173234, Himachal Pradesh, India.
[Ti] Título:Anti-proliferative effects of homeopathic medicines on human kidney, colon and breast cancer cells.
[So] Source:Homeopathy;102(4):274-82, 2013 Oct.
[Is] ISSN:1476-4245
[Cp] País de publicação:Scotland
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Homeopathy is controversial, due to the claims made for very high dilutions. Although several theories are proposed to understand the mechanisms of action, none are scientifically verified. This study aimed to investigate the efficacy of the selected homeopathic medicines in specific in vitro cancer models. METHODS: We assessed the cytotoxic activity of selected homeopathic medicines in mother tincture (MT), and ultramolecular dilution (30C, 200C, 1M and 10M) against cell lines deriving from tumors of particular organs, Sarsaparilla (Sars) on ACHN cells (human renal adenocarcinoma), Ruta graveolens (Ruta) on COLO-205 (human colorectal carcinoma), and Phytolacca decandra (Phyto) on MCF-7 (human breast carcinoma). Sars was also tested against Madin-Darby canine kidney (MDCK) cells (a non-malignant cell line). Cytotoxicity was measured using the 3-(4, 5-dimethylthiazolyl-2)-2, 5-diphenyltetrazolium bromide (MTT) method, anti-proliferative activity by trypan blue exclusion assay, apoptosis determined by dual staining the cells with ethidium bromide (EB) and acridine orange (AO) dyes. RESULTS: MTs and ultra-diluted preparations of the three homeopathic medicines had highly significant effects in the respective cancer cell lines, producing cytotoxicity and a decrease in cell proliferation. The effects were greatest with the MTs, but in all cases and persisted, although to a lesser degree in the ultra-diluted molecular preparations. Sars showed no effect on MDCK cells. In the homeopathic medicine treated cultures, hallmarks of apoptosis were evident including, cell shrinkage, chromatin condensation and DNA fragmentation. CONCLUSION: This study provides preliminary laboratory evidence indicating the ability of homeopathic medicines as anticancer agents. Further studies of the action of these homeopathic remedies are warranted.
[Mh] Termos MeSH primário: Antineoplásicos/farmacologia
Apoptose/efeitos dos fármacos
Neoplasias da Mama/tratamento farmacológico
Neoplasias do Colo/tratamento farmacológico
Homeopatia
Neoplasias Renais/tratamento farmacológico
Preparações de Plantas/farmacologia
[Mh] Termos MeSH secundário: Animais
Neoplasias da Mama/patologia
Linhagem Celular Tumoral/efeitos dos fármacos
Proliferação Celular/efeitos dos fármacos
Neoplasias do Colo/patologia
Citotoxinas/farmacologia
Cães
Feminino
Homeopatia/métodos
Seres Humanos
Neoplasias Renais/patologia
Phytolacca dodecandra
Fitoterapia
Ruta
Smilax
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Cytotoxins); 0 (Plant Preparations)
[Em] Mês de entrada:1404
[Cu] Atualização por classe:130920
[Lr] Data última revisão:
130920
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130921
[St] Status:MEDLINE


  3 / 15 MEDLINE  
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[PMID]:23010037
[Au] Autor:Das S; Das J; Samadder A; Bhattacharyya SS; Das D; Khuda-Bukhsh AR
[Ad] Endereço:Cytogenetics and Molecular Biology Laboratory, Department of Zoology, University of Kalyani, Kalyani 741235, India.
[Ti] Título:Biosynthesized silver nanoparticles by ethanolic extracts of Phytolacca decandra, Gelsemium sempervirens, Hydrastis canadensis and Thuja occidentalis induce differential cytotoxicity through G2/M arrest in A375 cells.
[So] Source:Colloids Surf B Biointerfaces;101:325-36, 2013 Jan 01.
[Is] ISSN:1873-4367
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:The capability of crude ethanolic extracts of certain medicinal plants like Phytolacca decandra, Gelsemium sempervirens, Hydrastis canadensis and Thuja occidentalis used as homeopathic mother tinctures in precipitating silver nanoparticles from aqueous solution of silver nitrate has been explored. Nanoparticles thus precipitated were characterized by spectroscopic, dynamic light scattering, X-ray diffraction, atomic force and transmission electron microscopic analyses. The drug-DNA interactions of silver nanoparticles were analyzed from data of circular dichroism spectroscopy and melting temperature profiles using calf thymus DNA (CT-DNA) as target. Biological activities of silver nanoparticles of different origin were then tested to evaluate their effective anti-proliferative and anti-bacterial properties, if any, by exposing them to A375 skin melanoma cells and to Escherichia coli C, respectively. Silver nanoparticles showed differences in their level of anti-cancer and anti-bacterial potentials. The nanoparticles of different origin interacted differently with CT-DNA, showing differences in their binding capacities. Particle size differences of the nanoparticles could be attributed for causing differences in their cellular entry and biological action. The ethanolic extracts of these plants had not been tested earlier for their possible efficacies in synthesizing nanoparticles from silver nitrate solution that had beneficial biological action, opening up a possibility of having therapeutic values in the management of diseases including cancer.
[Mh] Termos MeSH primário: Divisão Celular/efeitos dos fármacos
Sobrevivência Celular/efeitos dos fármacos
Fase G2/efeitos dos fármacos
Gelsemium/química
Hydrastis/química
Nanopartículas/química
Phytolacca dodecandra/química
Prata/química
Thuja/química
[Mh] Termos MeSH secundário: Compostos de Bifenilo/química
Linhagem Celular
Dicroísmo Circular
Ensaio Cometa
Dano ao DNA
Escherichia coli/efeitos dos fármacos
Etanol
Depuradores de Radicais Livres/química
Depuradores de Radicais Livres/farmacologia
Testes de Sensibilidade Microbiana
Microscopia de Força Atômica
Microscopia Eletrônica de Transmissão
Tamanho da Partícula
Picratos/química
Reação em Cadeia da Polimerase em Tempo Real
Nitrato de Prata/química
Solventes
Espectrofotometria Ultravioleta
Difração de Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Biphenyl Compounds); 0 (Free Radical Scavengers); 0 (Picrates); 0 (Solvents); 3K9958V90M (Ethanol); 3M4G523W1G (Silver); 95IT3W8JZE (Silver Nitrate); DFD3H4VGDH (1,1-diphenyl-2-picrylhydrazyl)
[Em] Mês de entrada:1305
[Cu] Atualização por classe:161125
[Lr] Data última revisão:
161125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:120927
[St] Status:MEDLINE


  4 / 15 MEDLINE  
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[PMID]:23569960
[Au] Autor:Mekonnen N; Makonnen E; Aklilu N; Ameni G
[Ad] Endereço:Department of Pharmacology, School of Medicine, Addis Ababa University, PO Box 1176, Addis Ababa, Ethiopia ; Aklilu Lemma Institute of Pathobiology, Addis Ababa University, PO Box 1176, Addis Ababa, Ethiopia.
[Ti] Título:Evaluation of berries of Phytolacca dodecandra for growth inhibition of Histoplasma capsulatum var. farciminosum and treatment of cases of epizootic lymphangitis in Ethiopia.
[So] Source:Asian Pac J Trop Biomed;2(7):505-10, 2012 Jul.
[Is] ISSN:2221-1691
[Cp] País de publicação:China
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: To evaluate the berries of Phytolacca dodecandra (P. dodecandra) for its effect on Histoplasma capsulatum var. farciminosum (HCF) and for the treatment of cases of epizootic lymphangitis (EL). METHODS: Samples were collected from un-ruptured nodules of cases of EL at Debre Zeit and Akaki (central Ethiopia). Mycological culture and isolation of HCF were performed at the Aklilu Lemma Institute of Pathobiology. Phytochemical screening was done for n-butanol extract of P. dodecandra to detect alkaloids, saponins, phenolic compounds and flavonoids. The minimum inhibitory concentrations (MICs) and minimum fungicidal concentrations (MFCs) of aqueous and n-butanol extracts of P. dodecandra against HCF were determined by agar dilution assay. For the in vivo trial, 5% simple ointment was prepared from n-butanol extract and applied topically to 24 (twelve early and twelve moderate) cases of EL. RESULTS: Phytochemical screening showed that n-butanol extract of P. dodecandra was positive for alkaloids, saponins and phenolic compounds but negative for flavonoids. The MICs of n-butanol and aqueous extracts of P. dodecandra were (0.039%-0.078%) and (0.625%-1.250%), respectively. The MFCs of n-butanol and aqueous extracts of P. dodecandra were (0.078%-0.156%) and (1.250%-2.500%), respectively. The MIC and MFC of ketoconazole (positive control) was (1.200×10(-5)%-2.500×10(-5)%) and (5.000×10(-5)%-1.000×10(-4)%), respectively while growth was observed on free medium (negative control). From the total of 24 treated cases of EL, 14 (58.3%) responded to treatment; however, 10 (41.7%) did not respond to treatment. There was no significant difference in the degree of response to treatment between early and moderate cases (χ(2)=0.686; P=0.408). CONCLUSIONS: It can be concluded that n-butanol extract of P. dodecandra demonstrates antifungal effects while the aqueous extract shows no antifungal activity.
[Mh] Termos MeSH primário: Antifúngicos/uso terapêutico
Frutas/química
Histoplasma/efeitos dos fármacos
Doenças dos Cavalos/tratamento farmacológico
Linfangite/veterinária
Phytolacca dodecandra/química
Extratos Vegetais/uso terapêutico
[Mh] Termos MeSH secundário: Animais
Antifúngicos/isolamento & purificação
Antifúngicos/farmacologia
Etiópia
Cavalos
Linfangite/tratamento farmacológico
Testes de Sensibilidade Microbiana
Extratos Vegetais/isolamento & purificação
Extratos Vegetais/farmacologia
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antifungal Agents); 0 (Plant Extracts)
[Em] Mês de entrada:1503
[Cu] Atualização por classe:150427
[Lr] Data última revisão:
150427
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:130410
[St] Status:MEDLINE
[do] DOI:10.1016/S2221-1691(12)60086-0


  5 / 15 MEDLINE  
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[PMID]:19146200
[Au] Autor:Karunamoorthi K; Bishaw D; Mulat T
[Ad] Endereço:School of Environmental Health Science, Faculty of Public Health, Jimma University, Jimma, Ethiopia. k_karunamoorthi@yahoo.com
[Ti] Título:Laboratory evaluation of Ethiopian local plant Phytolacca dodecandra extract for its toxicity effectiveness against aquatic macroinvertebrates.
[So] Source:Eur Rev Med Pharmacol Sci;12(6):381-6, 2008 Nov-Dec.
[Is] ISSN:1128-3602
[Cp] País de publicação:Italy
[La] Idioma:eng
[Ab] Resumo:In this study, we evaluated the toxicity effectiveness of berries crude extract of Endod [vernacular name (local native language, Amharic); Phytolacca dodecandra] against aquatic macroinvertebrates Baetidae (Mayflies) and Hydropsychidae (Caddisflies), under laboratory conditions. In Ethiopia, toxic plant, berries of Phytolacca dodecandra are being commonly used for washing clothes and to control fresh water snails. Macroinvertebrates are useful biological indicators of change in the aquatic ecosystems. The present study clearly revealed that the LC50 and LC90 values for berries crude extract of Phytolacca dodecandra against Baetidae were 181.94 and 525.78 mg/l and lethal doses (LC50 and LC90) required for Hydropsychidae were 1060.69 and 4120.4 mg/l respectively. The present investigation demonstrated that Baetidae was more susceptible than Hydropsychidae, even at shorter exposure period of 2 h. From our preliminary investigation the toxicity effectiveness of crude extracts of Phytolacca dodecandra has been clearly shown. In addition, it requires further explorations which address both the toxicity activity and the active principles that are responsible for its toxicity effectiveness. Ultimately, the release/introduction of Phytolacca dodecandra plant berries extracts into the river/streams leads to disruption of food chain in the aquatic ecosystem. Therefore, at this moment preserving the aquatic ecosystem is extremely essential and inevitable.
[Mh] Termos MeSH primário: Phytolacca dodecandra/toxicidade
Extratos Vegetais/toxicidade
[Mh] Termos MeSH secundário: Animais
Peixes
Dose Letal Mediana
Caramujos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Plant Extracts)
[Em] Mês de entrada:0901
[Cu] Atualização por classe:090116
[Lr] Data última revisão:
090116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:090117
[St] Status:MEDLINE


  6 / 15 MEDLINE  
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[PMID]:18575967
[Au] Autor:Hadush B; Ameni G; Medhin G
[Ad] Endereço:Faculty of Veterinary sciences, Mekelle University, P.O. BOX 231, Mekelle, Ethiopia. bselam12@yahoo.com
[Ti] Título:Equine histoplasmosis: treatment trial in cart horses in Central Ethiopia.
[So] Source:Trop Anim Health Prod;40(6):407-11, 2008 Aug.
[Is] ISSN:0049-4747
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Therapeutic effects of Sodium Iodide (NaI), Potassium Iodide (KI), ground berries of "Endod" (Phytolacca dodecandra) and Penstrip were evaluated on 70 cases of equine hitoplasmosis (EH). Response to each treatment was assessed using clinical examination of the lesions. Statistically significant difference (P = 0.0036) in therapeutic effect was observed among the different remedies. Cases treated either with a combination of NaI and Penstrip (F = 6.34, P = 0.004) or "Endod" and Penstrip (F = 3.64, P = 0.031) demonstrated significant response. The difference in response to treatment between early and advanced cases of EH was statistically significant (t = 2.22, P = 0.0148).
[Mh] Termos MeSH primário: Histoplasma/crescimento & desenvolvimento
Histoplasmose/veterinária
Doenças dos Cavalos/tratamento farmacológico
Doenças dos Cavalos/microbiologia
[Mh] Termos MeSH secundário: Animais
Histoplasmose/tratamento farmacológico
Histoplasmose/microbiologia
Histoplasmose/patologia
Doenças dos Cavalos/patologia
Cavalos
Penicilina G Procaína/uso terapêutico
Phytolacca dodecandra
Fitoterapia/veterinária
Iodeto de Potássio/uso terapêutico
Iodeto de Sódio/uso terapêutico
[Pt] Tipo de publicação:CLINICAL TRIAL; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
17R794ESYN (Penicillin G Procaine); 1C4QK22F9J (Potassium Iodide); F5WR8N145C (Sodium Iodide)
[Em] Mês de entrada:0809
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:080626
[St] Status:MEDLINE
[do] DOI:10.1007/s11250-007-9099-9


  7 / 15 MEDLINE  
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[PMID]:16370528
[Au] Autor:Woldeamanuel Y; Abate G; Chryssanthou E
[Ad] Endereço:Department of Microbiology, Immunology and Parasitology, Tikur Anbessa Hospital, P.O. Box 9086, Addis Ababa, Ethiopia.
[Ti] Título:In vitro activity of Phytolacca dodecandra (Endod) against dermatophytes.
[So] Source:Ethiop Med J;43(1):31-4, 2005 Jan.
[Is] ISSN:0014-1755
[Cp] País de publicação:Ethiopia
[La] Idioma:eng
[Ab] Resumo:There is a need for better and less costly treatment of superficial mycotic infections, and one approach might be testing of'traditionally used plants for their antifungal activities as potentials for drug development. The aim of the present study was to determine the in vitro activity of Phytolacca dodecandra (Endod) on various species of dermatophytes and yeasts of medical importance. The aqueous extract from the plant P. dodecandra was tested for its antifungal activity against 33 dermatophyte and yeast strains. The minimum inhibitory concentration (MIC) was determined by adopting the broth microdilution method for testing of conidium forming filamentous fungi according to the NCCLS M38-P proposed standard with some modifications. The MIC of P. dodecandra against the dermatophytes tested ranged from 19.5 mg/l to 156.0 mg/l, while for all the yeasts the MIC was >500 mg/l. The minimum inhibitory concentration for 50% (MIC50) of the dermatophyte strains was 62.5 mg/l. The extract showed fungicidal activity against the dermatophytes that ranged from 19.5 to 312.5 mg/l. No activity was observed against the yeasts. From our preliminary results antifungal activity of P. dodecandra has been shown. This should he strengthened with more extensive studies which address both the antifungal activity and the active principle that is responsible for its fungicidal activity.
[Mh] Termos MeSH primário: Antifúngicos/farmacologia
Arthrodermataceae/efeitos dos fármacos
Phytolacca dodecandra
Preparações de Plantas/farmacologia
[Mh] Termos MeSH secundário: Suscetibilidade a Doenças
Seres Humanos
Técnicas In Vitro
Testes de Sensibilidade Microbiana
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antifungal Agents); 0 (Plant Preparations)
[Em] Mês de entrada:0602
[Cu] Atualização por classe:141120
[Lr] Data última revisão:
141120
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:051224
[St] Status:MEDLINE


  8 / 15 MEDLINE  
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[PMID]:16099007
[Au] Autor:Abebe F; Erko B; Gemetchu T; Gundersen SG
[Ad] Endereço:Institute for Community Medicine, Department of International Health, University of Oslo, Norway. f.a.worke@medisin.uio.no
[Ti] Título:Control of Biomphalaria pfeifferi population and schistosomiasis transmission in Ethiopia using the soap berry endod (Phytolacca dodecandra), with special emphasis on application methods.
[So] Source:Trans R Soc Trop Med Hyg;99(10):787-94, 2005 Oct.
[Is] ISSN:0035-9203
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The endod (Phytolacca dodecandra)-based schistosomiasis mansoni control project was implemented in Ethiopia between 1994 and 1999. The aim was to develop an effective, cheap and sustainable method of controlling schistosomiasis. First, different formulations of the Ethiopian endod strain 44 (E-44) were compared for potency in the laboratory. Secondly, spray and drip-feeding methods were compared for simplicity and effectiveness in the field. Lastly, the efficacy of endod powder soap was compared with the endod spray method. In Bati stream, endod powder soap was distributed to the residents every weekend at laundry sites. In Worke stream, endod was sprayed along a 1-km stretch of the stream at 3-month intervals. No endod was applied in Harbu stream. The immediate and long-term effects of endod application on the snail population and schistosomal infection were determined. Using the spray method, 100% snail mortality could be obtained, and it was simpler and more effective than the drip-feeding method. Snail mortality ranged from 20 to 100% using endod soap. There was a progressive decline in the snail population and infection in Bati stream compared with Worke stream, mainly due to sustained use of endod soap. The advantages and disadvantages of the different endod delivery systems are discussed.
[Mh] Termos MeSH primário: Vetores de Doenças
Moluscocidas/uso terapêutico
Controle de Pragas/métodos
Phytolacca dodecandra
Esquistossomose mansoni/prevenção & controle
Sabões/uso terapêutico
[Mh] Termos MeSH secundário: Animais
Relação Dose-Resposta a Droga
Avaliação Pré-Clínica de Medicamentos/métodos
Etiópia/epidemiologia
Moluscocidas/química
Esquistossomose mansoni/epidemiologia
Esquistossomose mansoni/transmissão
Caramujos
Sabões/química
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Molluscacides); 0 (Soaps)
[Em] Mês de entrada:0601
[Cu] Atualização por classe:061115
[Lr] Data última revisão:
061115
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:050816
[St] Status:MEDLINE


  9 / 15 MEDLINE  
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[PMID]:15227973
[Au] Autor:Erko B; Medhin G; Balcha F; Raje S
[Ad] Endereço:Institute of Pathobiology, Addis Ababa University, P. O. Box 1176, Addis Ababa, Ethiopia.
[Ti] Título:Evaluation of pilot control trial of intestinal schistosomiasis in the Finchaa Sugar Estate, Ethiopia.
[So] Source:Ethiop Med J;41(2):141-50, 2003 Apr.
[Is] ISSN:0014-1755
[Cp] País de publicação:Ethiopia
[La] Idioma:eng
[Ab] Resumo:Intestinal schistosomiasis is undergoing a rapid increase in magnitude in Finchaa Sugar Estate in Ethiopia. A pilot control trial of intestinal schistosomiasis was instituted in 1995 to reduce the magnitude of the disease and introduce sustainable schistosomiasis control approaches in the Sugar Estate. Following initial parasitological survey of all the camps in the Sugar Project area in 1995 using Kato method, mass chemotherapy of the heavily infected residents of Camp 7 and selective treatment of lightly infected residents of other camps were made using praziquantel. Endod (type 44) was applied to transmission sites along Fekerie stream in Camp 7 on quarterly basis whenever Biomphalaria pfeifferi was detected. Other inputs to the project as parts of capacity building included transplantation of Endod cuttings (type 44), training and health education. Cross sectional parasitological surveys were made in 1998 to assess the impact of the pilot control trial. The results of stool examination showed that the prevalence of schistosomiasis was reduced from 30% in 1995 to 26% in 1998 among residents of Camp 7 and the intensity of infection from 198 eggs per gram of feces (EPG) in 1995 to 85 EPG in 1998. Similarly, the prevalence of infection among children in Finchaa Valley Elementary School was reduced from 78% in 1994 to 56% in 1998 and the reduction in respective intensity of infection was from 283 EPG to 114 EPG. Although significant reduction in the magnitude of the disease was not achieved, the control activities were taken over by the Sugar Project Polyclinic to ensure sustainability. In addition to chemotherapy and snail control using Endod, other disease non-specific methods such as health education should be used to get maximum benefit from such facilities as latrines, and ensure participation of the community in order to sustain the control activities.
[Mh] Termos MeSH primário: Agricultura
Biomphalaria/parasitologia
Água Doce/parasitologia
Controle de Pragas/métodos
Phytolacca dodecandra/envenenamento
Esquistossomose mansoni/prevenção & controle
[Mh] Termos MeSH secundário: Adolescente
Adulto
Animais
Biomphalaria/efeitos dos fármacos
Criança
Estudos Transversais
Etiópia/epidemiologia
Feminino
Inquéritos Epidemiológicos
Seres Humanos
Masculino
Meia-Idade
Projetos Piloto
Prevalência
Esquistossomose mansoni/epidemiologia
[Pt] Tipo de publicação:EVALUATION STUDIES; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:0408
[Cu] Atualização por classe:061115
[Lr] Data última revisão:
061115
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:040702
[St] Status:MEDLINE


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Fotocópia
[PMID]:12659970
[Au] Autor:Ndekha A; Hansen EH; Mølgaard P; Woelk G; Furu P
[Ad] Endereço:Royal Danish School of Pharmacy, Universitetsparken 2, DK 2100 Copenhagen, Denmark.
[Ti] Título:Community participation as an interactive learning process: experiences from a schistosomiasis control project in Zimbabwe.
[So] Source:Acta Trop;85(3):325-38, 2003 Mar.
[Is] ISSN:0001-706X
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:A schistosomiasis control project was undertaken from 1994 to 1998 in Guruve District, Zimbabwe, based on the active involvement of local communities in the growing and application of the molluscicidal plant Phytolacca dodecandra as a supplement to other control measures such as chemotherapy and health education. The berries of P. dodecandra are highly molluscicidal to the intermediate host snails of schistosomiasis and is rapidly degradable in water. It was observed that plant care fluctuated during the study period. Only a few households participated in snail control activities, although 97% of respondents in a baseline survey had stated a willingness to take part. This invoked an investigation to explore the reality from a user perspective. Focus group discussions, semi-structured interviews and observations were used to solicit information. In spite of a cultural inclination for collective work, many reasons for low-level involvement emerged, inter alia the low perceived value of the project, demands for tangible benefits, inaccessible fields and weak leadership. This study shows that community participation is a complex process upon which a multiplicity of social and cultural determinants have an impact. If community participation is to become successful in development programmes it ought to be viewed as a mutual learning process where obstacles are identified and discussed and solutions shared among community members and project staff.
[Mh] Termos MeSH primário: Participação da Comunidade/métodos
Moluscocidas/metabolismo
Controle Biológico de Vetores/métodos
Phytolacca dodecandra
Esquistossomose/prevenção & controle
Caramujos/crescimento & desenvolvimento
[Mh] Termos MeSH secundário: Animais
Comportamento Cooperativo
Seres Humanos
População Rural
Esquistossomose/parasitologia
Caramujos/parasitologia
Zimbábue
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Molluscacides)
[Em] Mês de entrada:0305
[Cu] Atualização por classe:161124
[Lr] Data última revisão:
161124
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:030328
[St] Status:MEDLINE



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