Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.198.500.937 [Categoria DeCS]
Referências encontradas : 216 [refinar]
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[PMID]:28359791
[Au] Autor:Kang CG; Im E; Lee HJ; Lee EO
[Ad] Endereço:Department of Cancer Preventive Material Development, Graduate School, Kyung Hee University, 26, Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Republic of Korea.
[Ti] Título:Plumbagin reduces osteopontin-induced invasion through inhibiting the Rho-associated kinase signaling pathway in A549 cells and suppresses osteopontin-induced lung metastasis in BalB/c mice.
[So] Source:Bioorg Med Chem Lett;27(9):1914-1918, 2017 05 01.
[Is] ISSN:1464-3405
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Lung cancer is the second most commonly diagnosed cancer and the leading cause of cancer deaths in both men and women in the United States. It has been recently demonstrated that osteopontin (OPN) effectively inhibits cofilin activity through the focal adhesion kinase (FAK)/AKT/Rho-associated kinase (ROCK) pathway to induce the invasion of human non-small cell lung cancer (NSCLC) cells. Plumbagin was isolated from the roots of the medicinal plant Plumbago zeylanica L. and has been reported to possess anticancer activities. However, the molecular mechanisms by which plumbagin inhibits the invasion of cancer cells is still unclear. In this study, the anti-invasive and anti-metastatic mechanisms of plumbagin were investigated in OPN-treated NSCLC A549 cells. OPN effectively induced the motility and invasion of NSCLC A549 cells and H1299 cells, which was strongly suppressed by plumbagin with no evidence of cytotoxicity. In addition, lamellipodia formation at the leading edge of cells by OPN was dramatically decreased in plumbagin-treated cells. Plumbagin caused an effective inhibition in OPN-induced the expression of ROCK1 as well as the phosphorylation of LIM kinase 1 and 2 (LIMK1/2), and cofilin. OPN-induced the phosphorylation of FAK and AKT was impaired without affecting their total forms by plumbagin treatment. OPN facilitated metastatic lung colonization, which was effectively suppressed in plumbagin-treated mice. Taken together, these results suggest that plumbagin reduces OPN-induced the invasion of NSCLC A549 cells, which resulted from inhibiting the ROCK pathway mediated by the FAK/AKT pathway and suppresses lung metastasis in vivo.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/uso terapêutico
Carcinoma Pulmonar de Células não Pequenas/tratamento farmacológico
Neoplasias Pulmonares/tratamento farmacológico
Naftoquinonas/uso terapêutico
Osteopontina/metabolismo
Inibidores de Proteínas Quinases/uso terapêutico
Quinases Associadas a rho/antagonistas & inibidores
[Mh] Termos MeSH secundário: Células A549
Animais
Antineoplásicos Fitogênicos/química
Antineoplásicos Fitogênicos/farmacologia
Carcinoma Pulmonar de Células não Pequenas/metabolismo
Carcinoma Pulmonar de Células não Pequenas/patologia
Movimento Celular/efeitos dos fármacos
Seres Humanos
Pulmão/efeitos dos fármacos
Pulmão/metabolismo
Pulmão/patologia
Neoplasias Pulmonares/metabolismo
Neoplasias Pulmonares/patologia
Masculino
Camundongos Endogâmicos BALB C
Camundongos Nus
Naftoquinonas/química
Naftoquinonas/farmacologia
Invasividade Neoplásica/patologia
Invasividade Neoplásica/prevenção & controle
Plumbaginaceae/química
Inibidores de Proteínas Quinases/química
Inibidores de Proteínas Quinases/farmacologia
Transdução de Sinais/efeitos dos fármacos
Quinases Associadas a rho/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Naphthoquinones); 0 (Protein Kinase Inhibitors); 106441-73-0 (Osteopontin); EC 2.7.11.1 (rho-Associated Kinases); YAS4TBQ4OQ (plumbagin)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171124
[Lr] Data última revisão:
171124
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170401
[St] Status:MEDLINE


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[PMID]:28359198
[Au] Autor:Liu Y; Cai Y; He C; Chen M; Li H
[Ad] Endereço:* Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, P.R. China.
[Ti] Título:Anticancer Properties and Pharmaceutical Applications of Plumbagin: A Review.
[So] Source:Am J Chin Med;45(3):423-441, 2017.
[Is] ISSN:0192-415X
[Cp] País de publicação:Singapore
[La] Idioma:eng
[Ab] Resumo:It has been shown that plumbagin, a bioactive naphthoquinone isolated from three major plant families viz. Plumbaginaceae, Ebenceae and Droseraceae, definitively exhibits anticancer potential in diverse cancer cells both in vitro and in vivo. Plumbagin shows antineoplastic effects via multi-channel molecular mechanisms, including the induction of apoptosis and autophagy, the disruption of the cell cycle, the inhibition of invasion and metastasis, and anti-angiogenesis. Plumbagin inhibits the growth of cancer cells mainly through the modulation of the signals of PI3K/Akt/mTOR, AMPK, Ras, and so on. The pharmaceutical applications of plumbagin combined with nanocarriers to achieve better therapeutic efficiency are discussed in this review Among them, liposomes, nanoparticles, microspheres, micelles, and nisosomes are used in cancer treatment. The anticancer study of plumbagin in vivo is also summarized in this review. On the whole, we aim to review the research progress of plumbagin both in pharmacological and pharmaceutical filed, which may provide some reference for further research of plumbagin.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos
Naftoquinonas/farmacologia
Naftoquinonas/uso terapêutico
Neoplasias/tratamento farmacológico
Fitoterapia
Transdução de Sinais/efeitos dos fármacos
[Mh] Termos MeSH secundário: Proteínas Quinases Ativadas por AMP
Animais
Apoptose/efeitos dos fármacos
Autofagia/efeitos dos fármacos
Droseraceae/química
Ebenaceae/química
Genes ras
Seres Humanos
Técnicas In Vitro
Camundongos
Naftoquinonas/isolamento & purificação
Neoplasias/genética
Neoplasias/patologia
Fosfatidilinositol 3-Quinase/metabolismo
Plumbaginaceae/química
Proteínas Proto-Oncogênicas c-akt/metabolismo
Transdução de Sinais/genética
Serina-Treonina Quinases TOR/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Naphthoquinones); EC 2.7.1.1 (TOR Serine-Threonine Kinases); EC 2.7.1.137 (Phosphatidylinositol 3-Kinase); EC 2.7.11.1 (Proto-Oncogene Proteins c-akt); EC 2.7.11.31 (AMP-Activated Protein Kinases); YAS4TBQ4OQ (plumbagin)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170401
[St] Status:MEDLINE
[do] DOI:10.1142/S0192415X17500264


  3 / 216 MEDLINE  
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[PMID]:28288871
[Au] Autor:de Oliveira Caleare A; Hensel A; Mello JC; Pinha AB; Panizzon GP; Lechtenberg M; Petereit F; Nakamura CV
[Ad] Endereço:State University of Maringá, Postgraduate Program in Biological Sciences, Laboratory of Technological Innovation in the Development of Drugs and Cosmetics, BR-87020-900, Maringá, Brazil.
[Ti] Título:Flavan-3-ols and proanthocyanidins from Limonium brasiliense inhibit the adhesion of Porphyromonas gingivalis to epithelial host cells by interaction with gingipains.
[So] Source:Fitoterapia;118:87-93, 2017 Apr.
[Is] ISSN:1873-6971
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Porphyromonas gingivalis is a pathogen strongly involved in chronic and aggressive forms of periodontitis. Natural products, mainly polyphenols, have been described for advanced treatment of periodontitis by inhibition of the bacterial adhesion of P. gingivalis to the epithelial host cells. An acetone:water extract (LBE) from the rhizomes of Limonium brasiliense (Boiss.) Kuntze was tested under in vitro conditions for potential antiadhesive effects against P. gingivalis to human KB cells and for inhibition of the proteolytic activity of gingipains, the main virulence factor of P. gingivalis. LBE≤100µg/mL had no cytotoxicity against the bacteria and did not influence the cell physiology of human epithelial KB cells. At 100µg/mL LBE reduced the adhesion of P. gingivalis to KB cells significantly by about 80%. LBE at 20µg/mL reduced the proteolytic activity of the arginin-specific Rgp gingipain by about 75%. Chemical profiling of LBE indicated the presence of gallic acid, epigallocatechin-3-O-gallate and samarangenins A and B as lead compounds. UHPLC by using MS and UV detection displays a suitable method for quality control of the extract for identification and quantification of the lead compounds.
[Mh] Termos MeSH primário: Aderência Bacteriana/efeitos dos fármacos
Flavonoides/química
Plumbaginaceae/química
Porphyromonas gingivalis/efeitos dos fármacos
Proantocianidinas/química
[Mh] Termos MeSH secundário: Adesinas Bacterianas/química
Benzopiranos/química
Benzopiranos/isolamento & purificação
Catequina/análogos & derivados
Catequina/química
Catequina/isolamento & purificação
Cisteína Endopeptidases/química
Células Epiteliais/microbiologia
Flavonoides/isolamento & purificação
Ácido Gálico/química
Ácido Gálico/isolamento & purificação
Seres Humanos
Células KB
Extratos Vegetais/química
Proantocianidinas/isolamento & purificação
Rizoma/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Adhesins, Bacterial); 0 (Benzopyrans); 0 (Flavonoids); 0 (Plant Extracts); 0 (Proanthocyanidins); 0 (samarangenin B); 35HDD3NRIE (flavan-3-ol); 632XD903SP (Gallic Acid); 8R1V1STN48 (Catechin); BQM438CTEL (epigallocatechin gallate); EC 3.4.22.- (Cysteine Endopeptidases); EC 3.4.22.37 (argingipain, Porphyromonas gingivalis)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170425
[Lr] Data última revisão:
170425
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170315
[St] Status:MEDLINE


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[PMID]:28108874
[Au] Autor:Jiménez A; Weigelt B; Santos-Guerra A; Caujapé-Castells J; Fernández-Palacios JM; Conti E
[Ad] Endereço:Department of Systematic and Evolutionary Botany and Botanical Garden, University of Zurich, Zollikerstrasse 107, 8008, Zurich, Switzerland. ares.jimenez@gmail.com.
[Ti] Título:Surviving in isolation: genetic variation, bottlenecks and reproductive strategies in the Canarian endemic Limonium macrophyllum (Plumbaginaceae).
[So] Source:Genetica;145(1):91-104, 2017 Feb.
[Is] ISSN:1573-6857
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Oceanic archipelagos are typically rich in endemic taxa, because they offer ideal conditions for diversification and speciation in isolation. One of the most remarkable evolutionary radiations on the Canary Islands comprises the 16 species included in Limonium subsection Nobiles, all of which are subject to diverse threats, and legally protected. Since many of them are single-island endemics limited to one or a few populations, there exists a risk that a loss of genetic variation might limit their long-term survival. In this study, we used eight newly developed microsatellite markers to characterize the levels of genetic variation and inbreeding in L. macrophyllum, a species endemic to the North-east of Tenerife that belongs to Limonium subsection Nobiles. We detected generally low levels of genetic variation over all populations (H = 0.363), and substantial differentiation among populations (F = 0.188; R = 0.186) coupled with a negligible degree of inbreeding (F = 0.042). Obligate outcrossing may have maintained L. macrophyllum relatively unaffected by inbreeding despite the species' limited dispersal ability and the genetic bottlenecks likely caused by a prolonged history of grazing. Although several factors still constitute a risk for the conservation of L. macrophyllum, the lack of inbreeding and the recent positive demographic trends observed in the populations of this species are factors that favour its future persistence.
[Mh] Termos MeSH primário: Variação Genética
Genética Populacional
Plumbaginaceae/genética
Isolamento Reprodutivo
[Mh] Termos MeSH secundário: DNA de Plantas
Loci Gênicos
Geografia
Endogamia
Repetições de Microssatélites
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Plant)
[Em] Mês de entrada:1702
[Cu] Atualização por classe:171020
[Lr] Data última revisão:
171020
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170122
[St] Status:MEDLINE
[do] DOI:10.1007/s10709-017-9948-z


  5 / 216 MEDLINE  
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[PMID]:28089736
[Au] Autor:Blainski A; Gionco B; Oliveira AG; Andrade G; Scarminio IS; Silva DB; Lopes NP; Mello JC
[Ad] Endereço:Programa de Pós-graduação em Ciências Farmacêuticas, Universidade Estadual de Maringá, Avenida Colombo, 5790, BR-87020-900 Maringá, PR, Brazil.
[Ti] Título:Antibacterial activity of Limonium brasiliense (Baicuru) against multidrug-resistant bacteria using a statistical mixture design.
[So] Source:J Ethnopharmacol;198:313-323, 2017 Feb 23.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:ETHNOPHARMACOLOGICAL RELEVANCE: Limonium brasiliense (Boiss.) Kuntze (Plumbaginaceae) is commonly known as "baicuru" or "guaicuru" and preparations of its dried rhizomes have been popularly used in the treatment of premenstrual syndrome and menstrual disorder, and as an antiseptic in genito-urinary infections. This study evaluated the potential antibacterial activity of rhizome extracts against multidrug-resistant bacterial strains using statistical mixture design. MATERIALS AND METHODS: The statistical design of four components (water, methanol, acetone, and ethanol) produced 15 different extracts and also a confirmatory experiment, which was performed using water:acetone (3:7, v/v). The crude extracts and their ethyl-acetate fractions were tested against vancomycin-resistant Enterococcus faecium (VREfm), methicillin-resistant Staphylococcus aureus (MRSA) and Klebsiella pneumoniae carbapenemase (KPC)-producing K. pneumoniae, all of which have been implicated in hospital and community-acquired infections. The dry residue, total polyphenol, gallocatechin and epigallocatechin contents of the extracts were also tested and statistical analysis was applied in order to define the fit models to predict the result of each parameter for any mixture of components. The principal component and hierarchical clustering analyses (PCA and HCA) of chromatographic data, as well as mass spectrometry (MS) analysis were performanced to determine the main compounds present in the extracts. RESULTS: The Gram-positive bacteria were susceptible to inhibition of bacterial growth, in special the ethyl-acetate fraction of ternary extracts from water:acetone:ethanol and methanol:acetone:ethanol against, respectively, VREfm (MIC=19µg/mL) and MRSA (MIC=39µg/mL). On the other hand, moderate activity of the ethyl-acetate fractions from primary (except water), secondary and ternary extracts (MIC=625µg/mL) was noted against KPC. The quadratic and special cubic models were significant for polyphenols and gallocatechin contents, respectively. Fit models to dry residue and epigallocatechin contents were not possible. PCA and HCA of the chromatographic fingerprints were disturbed by displacement retention time of some peaks, but the ultraviolet spectra indicated the homogeneous presence of flavan-3-ols characteristic of tannins. The MS confirmed the presence of gallic acid, gallocatechin, and epigallocatechin in extracts, and suggested the presence of monomers and dimers of B- and A-type prodelphinidins gallate, as well as a methyl gallate. CONCLUSION: Our results showed the antibacterial potential of L. brasiliense extracts against multidrug-resistant Gram-positive bacteria, such as VREfm and MRSA. The statistical design was a important tool to evaluate the biological activity by optimized form. The presence of some phenolic compounds was also demonstrated in extracts.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Bactérias Gram-Positivas/efeitos dos fármacos
Extratos Vegetais/farmacologia
Plumbaginaceae/química
[Mh] Termos MeSH secundário: Antibacterianos/isolamento & purificação
Farmacorresistência Bacteriana Múltipla
Espectrometria de Massas/métodos
Testes de Sensibilidade Microbiana
Análise de Componente Principal
Rizoma
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Plant Extracts)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170703
[Lr] Data última revisão:
170703
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170117
[St] Status:MEDLINE


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[PMID]:28056223
[Au] Autor:Feng WW; Wang TT; Bai JL; Ding P; Xing K; Jiang JH; Peng X; Qin S
[Ad] Endereço:The Key Laboratory of Biotechnology for Medicinal Plant of Jiangsu Province, School of Life Science, Jiangsu Normal University, Xuzhou, Jiangsu, 221116, PR China.
[Ti] Título:Glutamicibacter halophytocola sp. nov., an endophytic actinomycete isolated from the roots of a coastal halophyte, Limonium sinense.
[So] Source:Int J Syst Evol Microbiol;67(5):1120-1125, 2017 May.
[Is] ISSN:1466-5034
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A novel actinobacterium, designated KLBMP 5180T, was isolated from the surface-sterilized root of a coastal halophyte, Limonium sinense, collected from the city of Lianyungang, Jiangsu Province, eastern China. The isolate was Gram-stain-positive, aerobic and non-motile. The components of the cell-wall peptidoglycan were lysine, glutamic acid and alanine. The predominant menaquinone was MK-9. The polar lipids were diphosphatidylglycerol, phosphatidylglycerol, phosphatidylinositol, one unknown phospholipid, one unidentified glycolipid and two unidentified lipids. anteiso-C15 : 0 and iso-C16 : 0 were the major cellular fatty acids. The DNA G+C content of strain KLBMP 5180T was 60.0 mol%. Phylogenetic analysis based on 16S rRNA gene sequences showed that strain KLBMP 5180T belongs to the genus Glutamicibacter and was related most closely to Glutamicibacter nicotianae DSM 20123T (99.3 % similarity), Glutamicibacterarilaitensis Re117T (99.3 %) and Glutamicibacter mysorens LMG 16219T (99.1 %); similarity to other type strains of the genus Glutamicibacter was lower than 98.5 %. However, DNA-DNA relatedness values between strain KLBMP 5180T, G . nicotianae DSM 20123T, G. arilaitensis Re117T and G. mysorens LMG 16219T were 47.5±2.6, 51.3±3.1 and 41.2±4.3 %, respectively. The combination of DNA-DNA hybridization, phylogenetic, phenotypic and chemotaxonomic data supported the suggestion that strain KLBMP 5180T represents a novel species of the genus Glutamicibacter, for which the name Glutamicibacterhalophytocola sp. nov. is proposed. The type strain is KLBMP 5180T (=DSM 101718T=KCTC 39692T).
[Mh] Termos MeSH primário: Micrococcaceae/classificação
Filogenia
Raízes de Plantas/microbiologia
Plumbaginaceae/microbiologia
Plantas Tolerantes a Sal/microbiologia
[Mh] Termos MeSH secundário: Técnicas de Tipagem Bacteriana
Composição de Bases
China
DNA Bacteriano/genética
Ácidos Graxos/química
Micrococcaceae/genética
Micrococcaceae/isolamento & purificação
Hibridização de Ácido Nucleico
Peptidoglicano/química
Fosfolipídeos/química
RNA Ribossômico 16S/genética
Análise de Sequência de DNA
Vitamina K 2/análogos & derivados
Vitamina K 2/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Bacterial); 0 (Fatty Acids); 0 (Peptidoglycan); 0 (Phospholipids); 0 (RNA, Ribosomal, 16S); 11032-49-8 (Vitamin K 2); 523-39-7 (menaquinone 9)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170824
[Lr] Data última revisão:
170824
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170106
[St] Status:MEDLINE
[do] DOI:10.1099/ijsem.0.001775


  7 / 216 MEDLINE  
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[PMID]:27714795
[Au] Autor:Costa J; Castro S; Loureiro J; Barrett SC
[Ad] Endereço:Centre for Functional Ecology, Department of Life Sciences, University of Coimbra, Calçada Martim de Freitas, 3000-456, Coimbra, Portugal.
[Ti] Título:Experimental insights on the function of ancillary pollen and stigma polymorphisms in plants with heteromorphic incompatibility.
[So] Source:Evolution;71(1):121-134, 2017 Jan.
[Is] ISSN:1558-5646
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Most heterostylous plants possess a reciprocal arrangement of stigmas and anthers (reciprocal herkogamy), heteromorphic self-incompatibility, and ancillary polymorphisms of pollen and stigmas. The topographical complementarity hypothesis proposes that ancillary polymorphisms function in the rejection of incompatible pollen thus promoting disassortative pollination. Here, we test this hypothesis by investigating patterns of pollen transfer and capture in populations of dimorphic Armeria maritima and A. pubigera and distylous Limonium vulgare (Plumbaginaceae), and by studying pollen adherence and germination patterns in A. maritima following controlled hand-pollinations. Armeria lacks reciprocal herkogamy allowing the evaluation of the extent to which ancillary polymorphisms affect the composition of pollen loads. We compared the amounts of compatible and incompatible pollen on stigmas in natural populations and calculated the proficiencies of pollen transfer for each mating type. We detected disassortative pollination in each species, and mating types did not differ in compatible pollen capture, although cob stigmas captured more incompatible pollen. Controlled hand-pollinations revealed the failure of incompatible pollen to adhere and germinate on stigmas. Our results provided evidence that, while structural in nature, pollen-stigma dimorphisms are tightly associated with heteromorphic incompatibility and likely function to promote disassortative pollination, especially in the absence of reciprocal herkogamy.
[Mh] Termos MeSH primário: Flores/fisiologia
Plumbaginaceae/fisiologia
[Mh] Termos MeSH secundário: Flores/anatomia & histologia
Plumbaginaceae/anatomia & histologia
Pólen/anatomia & histologia
Pólen/fisiologia
Polinização
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170925
[Lr] Data última revisão:
170925
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161008
[St] Status:MEDLINE
[do] DOI:10.1111/evo.13082


  8 / 216 MEDLINE  
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[PMID]:27664671
[Au] Autor:Xu DP; Zheng J; Zhou Y; Li Y; Li S; Li HB
[Ad] Endereço:Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China.
[Ti] Título:Ultrasound-assisted extraction of natural antioxidants from the flower of Limonium sinuatum: Optimization and comparison with conventional methods.
[So] Source:Food Chem;217:552-559, 2017 Feb 15.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Natural antioxidants are widely used as dietary supplements or food additives. An optimized method of ultrasound-assisted extraction (UAE) was proposed for the effective extraction of antioxidants from the flowers of Limonium sinuatum and evaluated by response surface methodology. In this study, ethanol concentration, ratio of solvent to solid, ultrasonication time and temperature were investigated and optimized using a central composite rotatable design. The optimum extraction conditions were as follows: ethanol concentration, 60%; ratio of solvent to solid, 56.9:1mL/g; ultrasonication time, 9.8min; and temperature, 40°C. Under the optimal UAE conditions, the experimental values (483.01±15.39µmolTrolox/gDW) matched with those predicted (494.13µmolTrolox/gDW) within a 95% confidence level. In addition, the antioxidant activities of UAE were compared with those of conventional maceration and Soxhlet extraction methods, and the ultrasound-assisted extraction could give higher yield of antioxidants and markedly reduce the extraction time.
[Mh] Termos MeSH primário: Antioxidantes/análise
Flores/química
Plumbaginaceae/química
Ultrassom
[Mh] Termos MeSH secundário: Etanol/química
Extratos Vegetais/análise
Polifenóis/análise
Reprodutibilidade dos Testes
Solventes
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Plant Extracts); 0 (Polyphenols); 0 (Solvents); 3K9958V90M (Ethanol)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:170902
[Lr] Data última revisão:
170902
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160925
[St] Status:MEDLINE


  9 / 216 MEDLINE  
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[PMID]:27470940
[Au] Autor:Zhang CF; Ai MJ; Wang JX; Liu SW; Zhao LL; Su J; Sun CH; Yu LY; Zhang YQ
[Ad] Endereço:Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, PR China.
[Ti] Título:Herbihabitans rhizosphaerae gen. nov., sp. nov., a member of the family Pseudonocardiaceae isolated from rhizosphere soil of the herb Limonium sinense (Girard).
[So] Source:Int J Syst Evol Microbiol;66(10):4156-4161, 2016 Oct.
[Is] ISSN:1466-5034
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The taxonomic position of an actinobacterium, designated CPCC 204279T, which was isolated from a rhizosphere soil sample of the herb Limonium sinense collected from Xinjiang Province, China, was established using a polyphasic approach. Whole-cell hydrolysates of strain CPCC 204279T contained galactose and arabinose as diagnostic sugars and meso-diaminopimelic acid as the diamino acid. The muramic acid residues in the peptidoglycan were N-acetylated. The predominant menaquinone was MK-9(H4). The phospholipids consisted of diphosphatidylglycerol, phosphatidylethanolamine, phosphatidylinositol and phosphatidylinositol mannosides. The major fatty acids were iso-C16 : 0, iso-C16 : 0 2-OH, C16 : 1ω9c, iso-C16 : 1 and C16 : 0. The genomic DNA G+C content was 73.2 mol%. Phylogenetic analysis based on 16S rRNA gene sequences revealed that strain CPCC 204279T should be placed in the family Pseudonocardiaceae, in which the strain formed a distinct lineage next to the genus Actinophytocola. Signature nucleotides in the 16S rRNA gene sequence showed that the strain contained the Pseudonocardiaceae family-specific 16S rRNA signature nucleotides and a genus-specific diagnostic nucleotide signature pattern. The combination of phylogenetic analysis and phenotypic characteristics supported the conclusion that strain CPCC 204279T represents a novel species of a new genus in the family Pseudonocardiaceae, for which the name Herbihabitans rhizosphaerae gen. nov., sp. nov. is proposed. Strain CPCC 204279T (=NBRC 111774T=DSM 101727T) is the type strain of the type species.
[Mh] Termos MeSH primário: Actinomycetales/classificação
Filogenia
Plumbaginaceae/microbiologia
Rizosfera
Microbiologia do Solo
[Mh] Termos MeSH secundário: Actinomycetales/genética
Actinomycetales/isolamento & purificação
Técnicas de Tipagem Bacteriana
Composição de Bases
China
DNA Bacteriano/genética
Ácido Diaminopimélico/química
Ácidos Graxos/química
Ácidos Murâmicos/química
Peptidoglicano/química
Fosfolipídeos/química
RNA Ribossômico 16S/genética
Análise de Sequência de DNA
Vitamina K 2/análogos & derivados
Vitamina K 2/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Bacterial); 0 (Fatty Acids); 0 (Muramic Acids); 0 (Peptidoglycan); 0 (Phospholipids); 0 (RNA, Ribosomal, 16S); 11032-49-8 (Vitamin K 2); 523-39-7 (menaquinone 9); 583-93-7 (Diaminopimelic Acid)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160730
[St] Status:MEDLINE
[do] DOI:10.1099/ijsem.0.001325


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[PMID]:27461354
[Au] Autor:Seavers A; Robson D; Weingarth JM
[Ad] Endereço:Oak Flats Veterinary Clinic, 58A Central Avenue, Oak Flats, New South Wales 2529, Australia. aines@bigpond.com.
[Ti] Título:A vesicular (blistering) skin condition in a dog following putative contact exposure to Plumbago auriculata.
[So] Source:Aust Vet J;94(8):290-2, 2016 Aug.
[Is] ISSN:1751-0813
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:CASE REPORT: A 2-year-old male Airedale Terrier was presented with an acute and painful, predominantly ventral, vesicular skin eruption following putative dermal contact with Plumbago auriculata (Sky Flower, Leadwort). Prompt dermal decontamination and supportive therapy brought about a rapid recovery in the patient. CONCLUSION: Contact with botanical triggers is an important consideration for causes of acute vesicular skin conditions in dogs.
[Mh] Termos MeSH primário: Vesícula/veterinária
Dermatite de Contato/veterinária
Doenças do Cão/etiologia
Plumbaginaceae/efeitos adversos
[Mh] Termos MeSH secundário: Animais
Vesícula/diagnóstico
Vesícula/etiologia
Vesícula/patologia
Dermatite de Contato/diagnóstico
Dermatite de Contato/etiologia
Dermatite de Contato/patologia
Doenças do Cão/diagnóstico
Doenças do Cão/patologia
Cães
Masculino
Pele/patologia
[Pt] Tipo de publicação:CASE REPORTS
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170130
[Lr] Data última revisão:
170130
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160728
[St] Status:MEDLINE
[do] DOI:10.1111/avj.12461



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