Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.200.299 [Categoria DeCS]
Referências encontradas : 27 [refinar]
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  1 / 27 MEDLINE  
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[PMID]:27108479
[Au] Autor:Sebastian DJ; Nissen SJ; Westra P; Shaner DL; Butters G
[Ad] Endereço:Bioagricultural Science and Pest Management Department, Colorado State University, Fort Collins, CO, USA.
[Ti] Título:Influence of soil properties and soil moisture on the efficacy of indaziflam and flumioxazin on Kochia scoparia L.
[So] Source:Pest Manag Sci;73(2):444-451, 2017 Feb.
[Is] ISSN:1526-4998
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Kochia (Kochia scoparia L.) is a highly competitive, non-native weed found throughout the western United States. Flumioxazin and indaziflam are two broad-spectrum pre-emergence herbicides that can control kochia in a variety of crop and non-crop situations; however, under dry conditions, these herbicides sometimes fail to control this important weed. There is very little information describing the effect of soil properties and soil moisture on the efficacy of these herbicides. RESULTS: Soil organic matter (SOM) explained the highest proportion of variability in predicting the herbicide dose required for 80% kochia growth reduction (GR ) for flumioxazin and indaziflam (R = 0.72 and 0.79 respectively). SOM had a greater impact on flumioxazin phytotoxicity compared to indaziflam. Flumioxazin and indaziflam kochia phytotoxicity was greatly reduced at soil water potentials below -200 kPa. CONCLUSION: Kochia can germinate at soil moisture potentials below the moisture required for flumioxazin and indaziflam activation, which means that kochia control is greatly influenced by the complex interaction between soil physical properties and soil moisture. This research can be used to gain a better understanding of how and why some weeds, like kochia, are so difficult to manage even with herbicides that normally provide excellent control. © 2016 Society of Chemical Industry.
[Mh] Termos MeSH primário: Bassia scoparia/fisiologia
Benzoxazinas
Herbicidas
Indenos
Ftalimidas
Solo/química
Triazinas
Água/análise
[Mh] Termos MeSH secundário: Germinação/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Benzoxazines); 0 (Herbicides); 0 (Indenes); 0 (N-(2,3-dihydro-2,6-dimethyl-1H-inden-1-yl)-6-(1-fluoroethyl)-1,3,5-triazine-2,4-diamine); 0 (Phthalimides); 0 (Soil); 0 (Triazines); 059QF0KO0R (Water); L0PX7OGI22 (flumioxazin)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160426
[St] Status:MEDLINE
[do] DOI:10.1002/ps.4300


  2 / 27 MEDLINE  
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[PMID]:27992501
[Au] Autor:Gaines TA; Barker AL; Patterson EL; Westra P; Westra EP; Wilson RG; Jha P; Kumar V; Kniss AR
[Ad] Endereço:Department of Bioagricultural Sciences and Pest Management, Colorado State University, Fort Collins, Colorado, United States of America.
[Ti] Título:EPSPS Gene Copy Number and Whole-Plant Glyphosate Resistance Level in Kochia scoparia.
[So] Source:PLoS One;11(12):e0168295, 2016.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Glyphosate-resistant (GR) Kochia scoparia has evolved in dryland chemical fallow systems throughout North America and the mechanism of resistance involves 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS) gene duplication. Agricultural fields in four states were surveyed for K. scoparia in 2013 and tested for glyphosate-resistance level and EPSPS gene copy number. Glyphosate resistance was confirmed in K. scoparia populations collected from sugarbeet fields in Colorado, Wyoming, and Nebraska, and Montana. Glyphosate resistance was also confirmed in K. scoparia accessions collected from wheat-fallow fields in Montana. All GR samples had increased EPSPS gene copy number, with median population values up to 11 from sugarbeet fields and up to 13 in Montana wheat-fallow fields. The results indicate that glyphosate susceptibility can be accurately diagnosed using EPSPS gene copy number.
[Mh] Termos MeSH primário: 3-Fosfoshikimato 1-Carboxiviniltransferase/genética
Bassia scoparia
Dosagem de Genes
Glicina/análogos & derivados
Resistência a Herbicidas/genética
[Mh] Termos MeSH secundário: Bassia scoparia/efeitos dos fármacos
Bassia scoparia/genética
Amplificação de Genes
Regulação Enzimológica da Expressão Gênica
Regulação da Expressão Gênica de Plantas
Glicina/farmacologia
Herbicidas/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Herbicides); 4632WW1X5A (glyphosate); EC 2.5.1.19 (3-Phosphoshikimate 1-Carboxyvinyltransferase); TE7660XO1C (Glycine)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170705
[Lr] Data última revisão:
170705
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161220
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0168295


  3 / 27 MEDLINE  
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[PMID]:27854351
[Au] Autor:Jeon H; Kim DH; Nho YH; Park JE; Kim SN; Choi EH
[Ad] Endereço:Department of Dermatology, Yonsei University Wonju College of Medicine, Wonju 26426, Korea. moonlady84@naver.com.
[Ti] Título:A Mixture of Extracts of Kochia scoparia and Rosa multiflora with PPAR α/γ Dual Agonistic Effects Prevents Photoaging in Hairless Mice.
[So] Source:Int J Mol Sci;17(11), 2016 Nov 16.
[Is] ISSN:1422-0067
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Activation of peroxisome proliferator-activated receptors (PPAR) α/γ is known to inhibit the increases in matrix metalloproteinase (MMP) and reactive oxygen species (ROS) induced by ultraviolet light (UV). Extracts of natural herbs, such as and , have a PPAR α/γ dual agonistic effect. Therefore, we investigated whether and how they have an antiaging effect on photoaging skin. Eighteen-week-old hairless mice were irradiated with UVA 14 J/cm² and UVB 40 mJ/cm² three times a week for 8 weeks. A mixture of extracts of and (KR) was topically applied on the dorsal skin of photoaging mice twice a day for 8 weeks. Tesaglitazar, a known PPAR α/γ agonist, and vehicle (propylene glycol:ethanol = 7:3, / ) were applied as positive and negative controls, respectively. Dermal effects (including dermal thickness, collagen density, dermal expression of procollagen 1 and collagenase 13) and epidermal effects (including skin barrier function, epidermal proliferation, epidermal differentiation, and epidermal cytokines) were measured and compared. In photoaging murine skin, KR resulted in a significant recovery of dermal thickness as well as dermal fibroblasts, although it did not change dermal collagen density. KR increased the expression of dermal transforming growth factor (TGF)-ß. The dermal effects of KR were explained by an increase in procollagen 1 expression, induced by TGF-ß, and a decrease in MMP-13 expression. KR did not affect basal transepidermal water loss (TEWL) or stratum corneum (SC) integrity, but did decrease SC hydration. It also did not affect epidermal proliferation or epidermal differentiation. KR decreased the expression of epidermal interleukin (IL)-1α. Collectively, KR showed possible utility as a therapeutic agent for photoaging skin, with few epidermal side effects such as epidermal hyperplasia or poor differentiation.
[Mh] Termos MeSH primário: Bassia scoparia/química
PPAR alfa/agonistas
PPAR gama/agonistas
Extratos Vegetais/farmacologia
Rosa/química
Envelhecimento da Pele/efeitos dos fármacos
Envelhecimento da Pele/efeitos da radiação
[Mh] Termos MeSH secundário: Animais
Feminino
Regulação da Expressão Gênica/efeitos dos fármacos
Regulação da Expressão Gênica/efeitos da radiação
Metaloproteinase 1 da Matriz/análise
Metaloproteinase 1 da Matriz/genética
Metaloproteinase 13 da Matriz/genética
Camundongos Pelados
PPAR alfa/genética
PPAR gama/genética
Extratos Vegetais/química
Pró-Colágeno/genética
Pele/efeitos dos fármacos
Pele/metabolismo
Pele/efeitos da radiação
Pele/ultraestrutura
Fator de Crescimento Transformador beta/genética
Raios Ultravioleta/efeitos adversos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (PPAR alpha); 0 (PPAR gamma); 0 (Plant Extracts); 0 (Procollagen); 0 (Transforming Growth Factor beta); EC 3.4.24.- (Matrix Metalloproteinase 13); EC 3.4.24.7 (Matrix Metalloproteinase 1)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170417
[Lr] Data última revisão:
170417
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161118
[St] Status:MEDLINE


  4 / 27 MEDLINE  
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[PMID]:27616033
[Au] Autor:Han HY; Lee HE; Kim HJ; Jeong SH; Kim JH; Kim H; Ryu MH
[Ad] Endereço:Department of Oral Pathology, School of Dentistry, Research Institute for Oral Biotechnology, Pusan National University, Yangsan, Gyeongnam 50612, South Korea.
[Ti] Título:Kochia scoparia induces apoptosis of oral cancer cells in vitro and in heterotopic tumors.
[So] Source:J Ethnopharmacol;192:431-441, 2016 Nov 04.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:ETHNOPHARMACOLOGICAL RELEVANCE: Kochia scoparia grows commonly in China, Japan, and Korea and its mature fruit has been used throughout the area in traditional medicine to treat diseases including skin problems and inflammatory and allergic disease. More importantly, Kochia scoparia has been prescribed to treat the malignant tumor of head and neck region and breast mass. Although it has been proposed as an anti-cancer agent for several cancers, its exact in vivo anti-cancer properties and the molecular mechanisms underlying its effects are poorly understood. AIM OF THE STUDY: To evaluate the anti-cancer activity of the methanol extract of K. scoparia, mature fruit (MEKS) on oral squamous cell carcinoma (OSCC) and to explore its mode of action. MATERIALS AND METHODS: To assess proliferation inhibition and apoptosis induction by MEKS, MTT assays, cell analysis, ANNEXIN V and PI double staining, and Hoechst 33342 staining were performed. The activation of caspases and the MAP kinase p38 was evaluated using Western blot analysis. The anti-cancer properties of MEKS in vivo were elucidated in a heterotopic OSCC animal model. RESULTS: After OSCC cells were treated with MEKS, the numbers of sub-G1 accumulated cells and apoptotic bodies increased, indicating that MEKS inhibited OSCC cell proliferation selectively through induction of apoptosis. Apoptosis of MEKS-treated OSCC cells was induced in a dose-dependent manner by caspase-3 and -9 activation. In addition, pretreatment with p38 inhibitor SB203580 in combination with MEKS significantly prevented MEKS-induced apoptosis in OSCC cells and also decreased cleaved capase 3, 9, and cleaved PARP activity in western blotting. MEKS treatment significantly increased the apoptosis of OSCC and inhibited tumour growth in our animal model. CONCLUSION: Taken together, these results indicated that MEKS induced apoptosis of OSCC cells through caspase activation involving the p38 MAPK pathway. MEKS could be a promising anti-cancer candidate for OSCC treatment.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/farmacologia
Apoptose/efeitos dos fármacos
Bassia scoparia/química
Carcinoma de Células Escamosas/tratamento farmacológico
Neoplasias de Cabeça e Pescoço/tratamento farmacológico
Neoplasias Bucais/tratamento farmacológico
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Animais
Antineoplásicos Fitogênicos/isolamento & purificação
Carcinoma de Células Escamosas/metabolismo
Carcinoma de Células Escamosas/patologia
Caspases/metabolismo
Linhagem Celular Tumoral
Proliferação Celular/efeitos dos fármacos
Relação Dose-Resposta a Droga
Ativação Enzimática
Frutas/química
Neoplasias de Cabeça e Pescoço/metabolismo
Neoplasias de Cabeça e Pescoço/patologia
Seres Humanos
Masculino
Metanol/química
Camundongos Endogâmicos C3H
Neoplasias Bucais/metabolismo
Neoplasias Bucais/patologia
Paclitaxel/farmacologia
Fitoterapia
Extratos Vegetais/isolamento & purificação
Plantas Medicinais
Poli(ADP-Ribose) Polimerases/metabolismo
Transdução de Sinais/efeitos dos fármacos
Solventes/química
Carga Tumoral/efeitos dos fármacos
Proteínas Quinases p38 Ativadas por Mitógeno/metabolismo
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Plant Extracts); 0 (Solvents); EC 2.4.2.30 (Poly(ADP-ribose) Polymerases); EC 2.7.11.24 (p38 Mitogen-Activated Protein Kinases); EC 3.4.22.- (Caspases); P88XT4IS4D (Paclitaxel); Y4S76JWI15 (Methanol)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170912
[Lr] Data última revisão:
170912
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160913
[St] Status:MEDLINE


  5 / 27 MEDLINE  
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[PMID]:27537419
[Au] Autor:Kumar V; Jha P
[Ad] Endereço:Montana State University-Bozeman, Department of Research Centers, Southern Agricultural Research Center, Huntley, Montana, 59037, United States of America.
[Ti] Título:Differences in Germination, Growth, and Fecundity Characteristics of Dicamba-Fluroxypyr-Resistant and Susceptible Kochia scoparia.
[So] Source:PLoS One;11(8):e0161533, 2016.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The widespread occurrence of herbicide-resistant (HR) Kochia scoparia is an increasing concern for growers in the US Great Plains and Canada. K. scoparia populations resistant to dicamba have been reported in six US states. Populations cross-resistant to dicamba and fluroxypyr have been reported from wheat fields in Montana, USA. It is unclear whether resistance to the auxinic herbicides (dicamba and/or fluroxypyr), can alter the fitness traits of K. scoparia. The objectives of this research were to compare the germination dynamics in response to thermal environment, vegetative growth and fecundity characteristics, and the relative competitive ability of dicamba-fluroxypyr-susceptible (S) vs.-resistant (R) K. scoparia selected from within a single segregating population (collected from wheat-fallow field in MT). S and R selected lines were developed after three generations of recurrent group selection. Compared to the S selected line, the R selected line had lower cumulative germination at all constant temperatures except 25°C, and at all alternating temperatures except 30/35°C. Also, the R selected line had delayed germination relative to the S selected line. The R had lower plant height, plant width, primary branches, total leaf area, stem diameter, and shoot dry weight compared with the S plants in the absence of competition. The reduction in seed production per plant resulted in a 39% fitness cost. The 1000-seed weight of R (1.6 g) was also less than that of S (2.6 g). When grown in an intraspecific competition at different mixture proportions, replacement series indices for the growth parameters further indicated that the R was less competitive than the S. Evident from this research, the dicamba-fluroxypyr-resistant R selected line is less likely to persist in a field population in the absence of the auxinic herbicides.
[Mh] Termos MeSH primário: Acetatos/farmacologia
Bassia scoparia/fisiologia
Dicamba/farmacologia
Germinação/fisiologia
Resistência a Herbicidas
Herbicidas/farmacologia
Piridinas/farmacologia
[Mh] Termos MeSH secundário: Bassia scoparia/efeitos dos fármacos
Bassia scoparia/crescimento & desenvolvimento
Fertilidade/fisiologia
Resistência a Herbicidas/fisiologia
Sementes/crescimento & desenvolvimento
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Acetates); 0 (Herbicides); 0 (Pyridines); 8O40SHO197 (4,5-amino-3,5-dichloro-6-fluoro-2-pyridinyloxyacetic acid); SJG3M6RY6H (Dicamba)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160819
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0161533


  6 / 27 MEDLINE  
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[PMID]:26944112
[Au] Autor:Lisak RP; Nedelkoska L; Benjamins JA
[Ad] Endereço:Department of Neurology, Wayne State University School of Medicine, 3122 Elliman Building, 421 E. Canfield Ave., Detroit, MI 48201, United States.
[Ti] Título:The melanocortin ACTH 1-39 promotes protection of oligodendrocytes by astroglia.
[So] Source:J Neurol Sci;362:21-6, 2016 Mar 15.
[Is] ISSN:1878-5883
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Damage to myelin and oligodendroglia (OL) in multiple sclerosis (MS) results from a wide array of mechanisms including excitotoxicity, neuroinflammation and oxidative stress. We previously showed that ACTH 1-39, a melanocortin, protects OL in mixed glial cultures and enriched OL cultures, inhibiting OL death induced by staurosporine, ionotropic glutamate receptors, quinolinic acid or reactive oxygen species (ROS), but not nitric oxide (NO) or kynurenic acid. OL express melanocortin receptor 4 (MC4R), suggesting a direct protective effect of ACTH 1-39 on OL. However, these results do not rule out the possibility that astroglia (AS) or microglia (MG) also play roles in protection. To investigate this possibility, we prepared conditioned medium (CM) from AS and MG treated with ACTH, then assessed the protective effects of the CM on OL. CM from AS treated with ACTH protected OL from glutamate, NMDA, AMPA, quinolinic acid and ROS but not from kainate, staurosporine, NO or kynurenic acid. CM from MG treated with ACTH did not protect from any of these molecules, nor did CM from AS or MG not treated with ACTH. While protection of OL by ACTH from several toxic molecules involves direct effects on OL, ACTH can also stimulate AS to produce mediators that protect against some molecules but not others. Thus the cellular mechanisms underlying the protective effects of ACTH for OL are complex, varying with the toxic molecules.
[Mh] Termos MeSH primário: Hormônio Adrenocorticotrópico/farmacologia
Astrócitos/fisiologia
Hormônios/farmacologia
Oligodendroglia/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Animais Recém-Nascidos
Astrócitos/química
Bassia scoparia/citologia
Morte Celular/efeitos dos fármacos
Células Cultivadas
Meios de Cultivo Condicionados/farmacologia
Inibidores Enzimáticos/toxicidade
Agonistas de Aminoácidos Excitatórios/toxicidade
Peróxido de Hidrogênio/toxicidade
Oxidantes/toxicidade
Ratos
Estaurosporina/toxicidade
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Culture Media, Conditioned); 0 (Enzyme Inhibitors); 0 (Excitatory Amino Acid Agonists); 0 (Hormones); 0 (Oxidants); 9002-60-2 (Adrenocorticotropic Hormone); BBX060AN9V (Hydrogen Peroxide); H88EPA0A3N (Staurosporine)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160306
[St] Status:MEDLINE


  7 / 27 MEDLINE  
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[PMID]:26707133
[Au] Autor:Jo S; Ryu J; Han HY; Lee G; Ryu MH; Kim H
[Ad] Endereço:Department of Pharmacology, School of Korean Medicine, Pusan National University, Yangsan, Gyeongsangnam­do 626­870, Republic of Korea.
[Ti] Título:Anti-inflammatory activity of Kochia scoparia fruit on contact dermatitis in mice.
[So] Source:Mol Med Rep;13(2):1695-700, 2016 Feb.
[Is] ISSN:1791-3004
[Cp] País de publicação:Greece
[La] Idioma:eng
[Ab] Resumo:The mature fruit of Kochia scoparia (L.) Schrad. is widely administered in China and Korea as a medicinal herb for treatment of skin diseases, diabetes mellitus and rheumatoid arthritis. The present study investigated the effects of methanol extracts of K. scoparia dried fruit (MEKS) on ear swelling, histopathological changes (such as epidermal acanthosis, spongiosis and immune cell infiltration) and cytokine production in 1-fluoro-2,4-dinitrofluorobenzene (DNFB)-induced contact dermatitis mice. Topical application of MEKS inhibited DNFB-induced ear thickness and weight increases, as well as DNFB-induced epidermal acanthosis, spongiosis and immune cell infiltration. In addition, treatment with MEKS significantly decreased the levels of tumor necrosis factor-α, interferon-γ and monocyte chemotactic protein-1 in inflamed tissues. These data indicate that the mature fruit of K. scoparia has the potential to be administered for the treatment of inflammatory skin diseases and that the anti-inflammatory action of K. scoparia is involved in the inhibition of type 1 T helper cell skewing reactions.
[Mh] Termos MeSH primário: Anti-Inflamatórios/uso terapêutico
Bassia scoparia/química
Dermatite de Contato/tratamento farmacológico
Frutas/química
Extratos Vegetais/uso terapêutico
[Mh] Termos MeSH secundário: Animais
Anti-Inflamatórios/farmacologia
Peso Corporal/efeitos dos fármacos
Quimiocina CCL2/metabolismo
Dermatite de Contato/complicações
Dermatite de Contato/patologia
Dinitrofluorbenzeno
Orelha/patologia
Epiderme/efeitos dos fármacos
Epiderme/patologia
Inflamação/complicações
Inflamação/tratamento farmacológico
Inflamação/patologia
Interferon gama/metabolismo
Interleucina-10/metabolismo
Masculino
Camundongos Endogâmicos BALB C
Tamanho do Órgão/efeitos dos fármacos
Extratos Vegetais/farmacologia
Baço/efeitos dos fármacos
Baço/patologia
Fator de Necrose Tumoral alfa/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Ccl2 protein, mouse); 0 (Chemokine CCL2); 0 (Plant Extracts); 0 (Tumor Necrosis Factor-alpha); 130068-27-8 (Interleukin-10); 82115-62-6 (Interferon-gamma); D241E059U6 (Dinitrofluorobenzene)
[Em] Mês de entrada:1610
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151229
[St] Status:MEDLINE
[do] DOI:10.3892/mmr.2015.4698


  8 / 27 MEDLINE  
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[PMID]:26580558
[Au] Autor:Kumar V; Jha P
[Ad] Endereço:Montana State University-Bozeman, Southern Agricultural Research Center, Huntley, Montana, 59037, United States of America.
[Ti] Título:Growth and Reproduction of Glyphosate-Resistant and Susceptible Populations of Kochia scoparia.
[So] Source:PLoS One;10(11):e0142675, 2015.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Evolution of glyphosate-resistant kochia is a threat to no-till wheat-fallow and glyphosate-resistant (GR) cropping systems of the US Great Plains. The EPSPS (5-enol-pyruvylshikimate-3-phosphate synthase) gene amplification confers glyphosate resistance in the tested Kochia scoparia (L.) Schrad populations from Montana. Experiments were conducted in spring to fall 2014 (run 1) and summer 2014 to spring 2015 (run 2) to investigate the growth and reproductive traits of the GR vs. glyphosate-susceptible (SUS) populations of K. scoparia and to determine the relationship of EPSPS gene amplification with the level of glyphosate resistance. GR K. scoparia inbred lines (CHES01 and JOP01) exhibited 2 to 14 relative copies of the EPSPS gene compared with the SUS inbred line with only one copy. In the absence of glyphosate, no differences in growth and reproductive parameters were evident between the tested GR and SUS inbred lines, across an intraspecific competition gradient (1 to 170 plants m-2). GR K. scoparia plants with 2 to 4 copies of the EPSPS gene survived the field-use rate (870 g ha-1) of glyphosate, but failed to survive the 4,350 g ha-1 rate of glyphosate (five-times the field-use rate). In contrast, GR plants with 5 to 14 EPSPS gene copies survived the 4,350 g ha-1 of glyphosate. The results from this research indicate that GR K. scoparia with 5 or more EPSPS gene copies will most likely persist in field populations, irrespective of glyphosate selection pressure.
[Mh] Termos MeSH primário: 3-Fosfoshikimato 1-Carboxiviniltransferase/genética
Bassia scoparia/genética
Resistência a Herbicidas/genética
Triticum/parasitologia
[Mh] Termos MeSH secundário: 3-Fosfoshikimato 1-Carboxiviniltransferase/biossíntese
Bassia scoparia/efeitos dos fármacos
Bassia scoparia/crescimento & desenvolvimento
Dosagem de Genes
Regulação da Expressão Gênica de Plantas
Glicina/análogos & derivados
Glicina/farmacologia
Herbicidas/farmacologia
Reprodução/genética
Triticum/crescimento & desenvolvimento
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Herbicides); 4632WW1X5A (glyphosate); EC 2.5.1.19 (3-Phosphoshikimate 1-Carboxyvinyltransferase); TE7660XO1C (Glycine)
[Em] Mês de entrada:1606
[Cu] Atualização por classe:151126
[Lr] Data última revisão:
151126
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151119
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0142675


  9 / 27 MEDLINE  
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[PMID]:26218506
[Au] Autor:Yan H; Song Y; Zhou W; Zhang S
[Ad] Endereço:Department of Pharmacy, the First Hospital of Jilin University, Changchun 130021, PR China.
[Ti] Título:A selective and sensitive method based on UPLC-MS/MS for quantification of momordin Ic in rat plasma: application to a pharmacokinetic study.
[So] Source:J Pharm Biomed Anal;115:196-200, 2015 Nov 10.
[Is] ISSN:1873-264X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A selective and sensitive method was developed and validated based on ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). This method was applied to quantify momordin Ic in rat plasma. Chromatographic separation was performed on a Hypersil GOLD HPLC C18 column (150mm×4.6mm, 5µm) using an isocratic mobile phase of acetonitrile/water (80:20, v/v) at a flow rate of 0.6mL/min. An electrospray ionization source was applied and operated in negative ion mode; selected reaction monitoring (SRM) mode was used for quantification by monitoring the precursor-to-product ion transitions of m/z 763.4→m/z 455.3 for momordin Ic, and m/z 649.4→m/z 487.3 for IS. Calibration curves showed good linearity over the range of 22.0-2200ng/mL for momordin Ic in rat plasma. The developed method was applied to a pharmacokinetic study of momordin Ic in rats after single intravenous doses at 0.52, 1.56, and 4.67mg/kg. The elimination half-life (t1/2) values were 1.22±0.39, 1.14±0.10, and 1.83±0.39h, respectively. The plasma concentration at 2min (C2min) and area under the curve (AUC) for the intravenous doses of momordin Ic were approximately dose proportional.
[Mh] Termos MeSH primário: Bassia scoparia/química
Cromatografia Líquida de Alta Pressão/métodos
Medicamentos de Ervas Chinesas/farmacocinética
Ácido Oleanólico/análogos & derivados
Espectrometria de Massas em Tandem/métodos
[Mh] Termos MeSH secundário: Animais
Área Sob a Curva
Calibragem
Medicamentos de Ervas Chinesas/isolamento & purificação
Meia-Vida
Masculino
Ácido Oleanólico/sangue
Controle de Qualidade
Ratos Sprague-Dawley
Padrões de Referência
Sensibilidade e Especificidade
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Drugs, Chinese Herbal); 0 (momordin I (Oleanolic Acid)); 6SMK8R7TGJ (Oleanolic Acid)
[Em] Mês de entrada:1606
[Cu] Atualização por classe:150921
[Lr] Data última revisão:
150921
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150729
[St] Status:MEDLINE


  10 / 27 MEDLINE  
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[PMID]:25950428
[Au] Autor:Varanasi VK; Godar AS; Currie RS; Dille AJ; Thompson CR; Stahlman PW; Jugulam M
[Ad] Endereço:Department of Agronomy, Kansas State University, Manhattan, KS, USA.
[Ti] Título:Field-evolved resistance to four modes of action of herbicides in a single kochia (Kochia scoparia L. Schrad.) population.
[So] Source:Pest Manag Sci;71(9):1207-12, 2015 Sep.
[Is] ISSN:1526-4998
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Evolution of multiple herbicide resistance in weeds is a serious threat to weed management in crop production. Kochia is an economically important broadleaf weed in the U.S. Great Plains. This study aimed to confirm resistance to four sites of action of herbicides in a single kochia (Kochia scoparia L. Schrad.) population from a crop field near Garden City (GC), Kansas, and further determine the underlying mechanisms of resistance. RESULTS: One-fourth of the GC plants survived the labeled rate or higher of atrazine [photosystem II (PSII) inhibitor], and the surviving plants had the Ser-264 to Gly mutation in the psbA gene, the target site of atrazine. Results showed that 90% of GC plants survived the labeled rate of dicamba, a synthetic auxin. At least 87% of the plants survived up to 72 g a.i. ha(-1) of chlorsulfuron [acetolactate synthase (ALS) inhibitor], and analysis of the ALS gene revealed the presence of Pro-197 to Thr and/or Trp-574 to Lue mutation(s). Most GC plants also survived the labeled rate of glyphosate [5-enolpyruvylshikimate-3-phosphate synthase (EPSPS) inhibitor), and the resistant plants had 5-9 EPSPS gene copies (relative to the ALS gene). CONCLUSION: We confirm the first case of evolution of resistance to four herbicide sites of action (PSII, ALS and EPSPS inhibitors and synthetic auxins) in a single kochia population, and target-site-based mechanisms confer resistance to atrazine, glyphosate and chlorsulfuron.
[Mh] Termos MeSH primário: Bassia scoparia/fisiologia
Resistência a Herbicidas
Herbicidas
[Mh] Termos MeSH secundário: Atrazina
Bassia scoparia/genética
DNA de Plantas/genética
Dicamba
Glicina/análogos & derivados
Kansas
Mutação
Plantas Daninhas
Sulfonamidas
Triazinas
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (DNA, Plant); 0 (Herbicides); 0 (Sulfonamides); 0 (Triazines); 4632WW1X5A (glyphosate); O6S620ML45 (chlorsulfuron); QJA9M5H4IM (Atrazine); SJG3M6RY6H (Dicamba); TE7660XO1C (Glycine)
[Em] Mês de entrada:1607
[Cu] Atualização por classe:150727
[Lr] Data última revisão:
150727
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150508
[St] Status:MEDLINE
[do] DOI:10.1002/ps.4034



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