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[PMID]:28829803
[Au] Autor:Mishra P; Kumar A; Nagireddy A; Shukla AK; Sundaresan V
[Ad] Endereço:Plant Biology and Systematics, CSIR-Central Institute of Medicinal and Aromatic Plants, Research Center, Bengaluru, Karnataka, India.
[Ti] Título:Evaluation of single and multilocus DNA barcodes towards species delineation in complex tree genus Terminalia.
[So] Source:PLoS One;12(8):e0182836, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:DNA barcoding is used as a universal tool for delimiting species boundaries in taxonomically challenging groups, with different plastid and nuclear regions (rbcL, matK, ITS and psbA-trnH) being recommended as primary DNA barcodes for plants. We evaluated the feasibility of using these regions in the species-rich genus Terminalia, which exhibits various overlapping morphotypes with pantropical distribution, owing to its complex taxonomy. Terminalia bellerica and T. chebula are ingredients of the famous Ayurvedic Rasayana formulation Triphala, used for detoxification and rejuvenation. High demand for extracted phytochemicals as well as the high trade value of several species renders mandatory the need for the correct identification of traded plant material. Three different analytical methods with single and multilocus barcoding regions were tested to develop a DNA barcode reference library from 222 individuals representing 41 Terminalia species. All the single barcodes tested had a lower discriminatory power than the multilocus regions, and the combination of matK+ITS had the highest resolution rate (94.44%). The average intra-specific variations (0.0188±0.0019) were less than the distance to the nearest neighbour (0.106±0.009) with matK and ITS. Distance-based Neighbour Joining analysis outperformed the character-based Maximum Parsimony method in the identification of traded species such as T. arjuna, T. chebula and T. tomentosa, which are prone to adulteration. rbcL was shown to be a highly conservative region with only 3.45% variability between all of the sequences. The recommended barcode combination, rbcL+matK, failed to perform in the genus Terminalia. Considering the complexity of resolution observed with single regions, the present study proposes the combination of matK+ITS as the most successful barcode in Terminalia.
[Mh] Termos MeSH primário: Combretaceae/genética
Código de Barras de DNA Taxonômico/métodos
[Mh] Termos MeSH secundário: Genes de Plantas
Especificidade da Espécie
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171016
[Lr] Data última revisão:
171016
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170823
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0182836


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[PMID]:28768515
[Au] Autor:Olugbami JO; Damoiseaux R; France B; Onibiyo EM; Gbadegesin MA; Sharma S; Gimzewski JK; Odunola OA
[Ad] Endereço:Department of Biochemistry, Cancer Research and Molecular Biology (CRMB) Laboratories, University of Ibadan, Ibadan, Oyo, Nigeria.
[Ti] Título:A comparative assessment of antiproliferative properties of resveratrol and ethanol leaf extract of Anogeissus leiocarpus (DC) Guill and Perr against HepG2 hepatocarcinoma cells.
[So] Source:BMC Complement Altern Med;17(1):381, 2017 Aug 02.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Epidemiological and experimental evidences have shown cancer as a leading cause of death worldwide. Although the folklore use of plants as a reliable source of health-restoring principles is well-documented, the search for more of such plants that are active against diseases, such as cancer, continues. We report here a laboratory-based evidence of the relevance of an ethanol leaf extract of Anogeissus leiocarpus (A2L) in comparison with resveratrol, a natural polyphenol, in cancer therapy. METHODS: The quantitative assessment of flavonoid and phenolic contents involved quercetin and gallic acid as standards, respectively were determined using spectrophotometry. Cytotoxicity was determined fluorometrically using propidium-iodide-staining method. Antioxidant status, adenosine triphosphate (ATP) levels, caspase activities and mitochondrial integrity were assessed using fluorometry/luminometry. RESULTS: The antioxidant assay demonstrated that A2L possesses a strong antioxidant capacity as compared with the reference compounds, ascorbic acid and butylated hydroxytoluene. This is further buttressed by the significantly high level of phenolics obtained in the quantitative assessment of the extract. A 72-h post-treatment examination indicated that both A2L and resveratrol modulate the proliferation of HepG2 liver carcinoma cells in a time- and concentration-dependent manner. Determination of the total nuclei area, propidium-iodide negative and positive nuclei areas all further buttress the modulation of cell proliferation by A2L and resveratrol with the indication that the observed cell death is due to apoptosis and necrosis at lower and higher concentrations of treatments respectively. At lower concentrations (0.39-3.13 µg/mL), resveratrol possesses higher tendencies to activate caspases 3 and 7. Bioenergetically, both resveratrol and A2L do not adversely affect the cells at lower concentrations (0.39-6.25 µg/mL for resveratrol and 12.5-100.0 µg/mL for A2L) except at higher concentrations (12.5-25.0 µg/mL for resveratrol and 200-800 µg/mL for A2L) which are more pronounced in A2L-treated cells. Furthermore, the antioxidant status of HepG2 cells is not perturbed by resveratrol as compared with A2L. Assessment of 24-h post-treatment mitochondrial function shows that resveratrol is not mitotoxic as compared with A2L which exhibits mitotoxicity at its highest concentration. CONCLUSIONS: Taken together, findings from this study showed that A2L possesses strong antiproliferative activity and its prospect in the management of hepatocellular carcinoma deserves further investigation.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/uso terapêutico
Antioxidantes/uso terapêutico
Carcinoma Hepatocelular/tratamento farmacológico
Combretaceae/química
Neoplasias Hepáticas/tratamento farmacológico
Fitoterapia
Estilbenos/uso terapêutico
[Mh] Termos MeSH secundário: Trifosfato de Adenosina/metabolismo
Antineoplásicos Fitogênicos/farmacologia
Antioxidantes/farmacologia
Apoptose
Carcinoma Hepatocelular/metabolismo
Caspases/metabolismo
Proliferação Celular
Combretaceae/classificação
Flavonoides/farmacologia
Flavonoides/uso terapêutico
Células Hep G2
Seres Humanos
Neoplasias Hepáticas/metabolismo
Mitocôndrias/efeitos dos fármacos
Mitocôndrias/metabolismo
Necrose
Fenóis/farmacologia
Fenóis/uso terapêutico
Extratos Vegetais/farmacologia
Extratos Vegetais/uso terapêutico
Folhas de Planta
Estilbenos/farmacologia
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Antioxidants); 0 (Flavonoids); 0 (Phenols); 0 (Plant Extracts); 0 (Stilbenes); 8L70Q75FXE (Adenosine Triphosphate); EC 3.4.22.- (Caspases); Q369O8926L (resveratrol)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170901
[Lr] Data última revisão:
170901
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170804
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-1873-2


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[PMID]:28376640
[Au] Autor:Cavalcanti Filho JR; Silva TF; Nobre WQ; Oliveira de Souza LI; Silva E Silva Figueiredo CS; Figueiredo RC; de Gusmão NB; Silva MV; Nascimento da Silva LC; Correia MT
[Ad] Endereço:a Departamento de Bioquímica , Universidade Federal de Pernambuco , Recife , Brasil.
[Ti] Título:Antimicrobial activity of Buchenavia tetraphylla against Candida albicans strains isolated from vaginal secretions.
[So] Source:Pharm Biol;55(1):1521-1527, 2017 Dec.
[Is] ISSN:1744-5116
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:CONTEXT: Buchenavia tetraphylla (Aubl.) RA Howard (Combretaceae: Combretoideae) is an ethnomedicinal plant with reported antifungal action. OBJECTIVE: This study evaluates the antimicrobial activity of B. tetraphylla leaf extracts against clinical isolates of Candida albicans. The morphological alterations, combinatory effects with fluconazole and the cytotoxicity of the active extract were analyzed. MATERIALS AND METHODS: Extracts were obtained using different solvents (hexane: BTHE; chloroform: BTCE; ethyl acetate: BTEE; and methanol: BTME). Antimicrobial activity was determined by the broth microdilution method using nine strains of C. albicans isolated from vaginal secretions and one standard strain (UFPEDA 1007). RESULTS: All extracts showed anti-C. albicans activity, including against the azole-resistant strains. The MIC values ranged from 156 to 2500 µg/mL for the BTHE; 156 to 1250 µg/mL for the BTCE; 625 to 1250 µg/mL for the BTME and 625 µg/mL to 2500 µg/mL for the BTEE. BTME showed the best anti-C. albicans activity. This extract demonstrated additive/synergistic interactions with fluconazole. Scanning electron microscopy analysis suggested that the BTME interferes with the cell division and development of C. albicans. BTME showed IC values of 981 and 3935 µg/mL, against J774 macrophages and human erythrocytes, respectively. This extract also enhanced the production of nitric oxide by J774 macrophages. DISCUSSION AND CONCLUSION: Buchenavia tetraphylla methanolic extract (BTME) is a great source of antimicrobial compounds that are able to enhance the action of fluconazole against different C. albicans strains; this action seems related to inhibition of cell division.
[Mh] Termos MeSH primário: Antifúngicos/farmacologia
Candida albicans/efeitos dos fármacos
Combretaceae/química
Extratos Vegetais/farmacologia
Vagina/microbiologia
[Mh] Termos MeSH secundário: Animais
Antifúngicos/isolamento & purificação
Antifúngicos/toxicidade
Candida albicans/crescimento & desenvolvimento
Candida albicans/isolamento & purificação
Candida albicans/ultraestrutura
Linhagem Celular
Sobrevivência Celular/efeitos dos fármacos
Farmacorresistência Fúngica
Quimioterapia Combinada
Feminino
Fluconazol/farmacologia
Hemólise/efeitos dos fármacos
Seres Humanos
Macrófagos/efeitos dos fármacos
Macrófagos/metabolismo
Macrófagos/patologia
Camundongos
Testes de Sensibilidade Microbiana
Óxido Nítrico/metabolismo
Fitoterapia
Extratos Vegetais/isolamento & purificação
Extratos Vegetais/toxicidade
Plantas Medicinais
Solventes/química
Vagina/secreção
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antifungal Agents); 0 (Plant Extracts); 0 (Solvents); 31C4KY9ESH (Nitric Oxide); 8VZV102JFY (Fluconazole)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170605
[Lr] Data última revisão:
170605
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170406
[St] Status:MEDLINE
[do] DOI:10.1080/13880209.2017.1304427


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[PMID]:28283004
[Au] Autor:Alam P; Parvez MK; Arbab AH; Al-Dosari MS
[Ad] Endereço:a Department of Pharmacognosy, College of Pharmacy , King Saud University , Riyadh , Saudi Arabia.
[Ti] Título:Quantitative analysis of rutin, quercetin, naringenin, and gallic acid by validated RP- and NP-HPTLC methods for quality control of anti-HBV active extract of Guiera senegalensis.
[So] Source:Pharm Biol;55(1):1317-1323, 2017 Dec.
[Is] ISSN:1744-5116
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:CONTEXT: Guiera senegalensis J.F. Gmel (Combretaceae) is a folk medicinal plant used in various metabolic and infectious diseases. In addition to its antiviral activities against herpes and fowlpox, the anti-HBV efficacy is very recently reported. OBJECTIVE: To develop and validate simple, sensitive RP-/NP-HPTLC methods for quantitative determination of biomarkers rutin, quercetin, naringenin, and gallic acid in the anti-HBV active G. senegalensis leaves ethanol-extract. MATERIALS AND METHODS: RP-HPTLC (rutin & quercetin; phase- acetonitrile:water, 4:6) and NP-HPTLC (naringenin & gallic acid; phase- toluene:ethyl acetate:formic acid, 6:4:0.8) were performed on glass-backed silica gel plates 60F -RP18 and 60F , respectively. The methods were validated according to the ICH guidelines. RESULTS: Well-separated and compact spots (R ) of rutin (0.52 ± 0.006), quercetin (0.23 ± 0.005), naringenin (0.56 ± 0.009) and gallic acid (0.28 ± 0.006) were detected. The regression equations (Y) were 12.434x + 443.49, 10.08x + 216.85, 11.253x + 973.52 and 11.082x + 446.41 whereas the coefficient correlations (r ) were 0.997 ± 0.0004, 0.9982 ± 0.0001, 0.9974 ± 0.0004 and 0.9981 ± 0.0001, respectively. The linearity ranges (ng/spot) were 200-1400 (RP-HPTLC) and 100-1200 (NP-HPTLC). The LOD/LOQ (ng/band) were 33.03/100.1 (rutin), 9.67/29.31 (quercetin), 35.574/107.8 (naringenin), and 12.32/37.35 (gallic acid). Gallic acid (7.01 µg/mg) was the most abundant biomarker compared to rutin (2.42 µg/mg), quercetin (1.53 µg/mg) and naringenin (0.14 µg/mg) in the extract. CONCLUSION: The validated NP-/RP-HPTLC methods were simple, accurate, and sensitive for separating and quantifying antiviral biomarkers in G. senegalensis, and endorsed its anti-HBV activity. The developed methods could be further employed in the standardization and quality-control of herbal formulations.
[Mh] Termos MeSH primário: Antivirais/análise
Combretaceae
Flavanonas/análise
Ácido Gálico/análise
Quercetina/análise
Rutina/análise
[Mh] Termos MeSH secundário: Cromatografia em Camada Delgada/métodos
Vírus da Hepatite B
Extratos Vegetais/análise
Folhas de Planta
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antiviral Agents); 0 (Flavanones); 0 (Plant Extracts); 5G06TVY3R7 (Rutin); 632XD903SP (Gallic Acid); 9IKM0I5T1E (Quercetin); HN5425SBF2 (naringenin)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170321
[Lr] Data última revisão:
170321
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170312
[St] Status:MEDLINE
[do] DOI:10.1080/13880209.2017.1300175


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[PMID]:28245269
[Au] Autor:Yashavantha Rao HC; Rakshith D; Harini BP; Gurudatt DM; Satish S
[Ad] Endereço:Microbial Drugs Laboratory, Department of Studies in Microbiology, University of Mysore, Manasagangotri, Mysore, Karnataka, India.
[Ti] Título:Chemogenomics driven discovery of endogenous polyketide anti-infective compounds from endosymbiotic Emericella variecolor CLB38 and their RNA secondary structure analysis.
[So] Source:PLoS One;12(2):e0172848, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In the postgenomic era, a new strategy for chemical dereplication of polyketide anti-infective drugs requires novel genomics and chromatographic strategies. An endosymbiotic fungal strain CLB38 was isolated from the root tissue of Combretum latifolium Blume (Combretaceae) which was collected from the Western Ghats of India. The isolate CLB38 was then identified as Emericella variecolor by its characteristic stellate ascospores culture morphology and molecular analysis of ITS nuclear rDNA and intervening 5.8S rRNA gene sequence. ITS2 RNA secondary structure modeling clearly distinguished fungal endosymbiont E. variecolor CLB38 with other lifestyles in the same monophyletic clade. Ethyl acetate fraction of CLB38 explored a broad spectrum of antimicrobial activity against multidrug resistant pathogens. Biosynthetic PKS type-I gene and chromatographic approach afford two polyketide antimicrobial compounds which identified as evariquinone and isoindolones derivative emerimidine A. MIC of purified compounds against test microorganisms ranged between 3.12 µg/ml and 12.5 µg/ml. This research highlights the utility of E. variecolor CLB38 as an anticipate source for anti-infective polyketide metabolites evariquinone and emerimidine A to combat multidrug resistant microorganisms. Here we demonstrates a chemogenomics strategy via the feasibility of PKS type-I gene and chromatographic approach as a proficient method for the rapid prediction and discovery of new polyketides compounds from fungal endosymbionts.
[Mh] Termos MeSH primário: Combretaceae/microbiologia
Emericella/química
Emericella/fisiologia
[Mh] Termos MeSH secundário: Anti-Infecciosos/química
Anti-Infecciosos/farmacologia
DNA Ribossômico/genética
Emericella/genética
Isoindóis/química
Isoindóis/farmacologia
Testes de Sensibilidade Microbiana
Policetídeos/química
Policetídeos/farmacologia
RNA Fúngico/genética
Simbiose
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Infective Agents); 0 (DNA, Ribosomal); 0 (Isoindoles); 0 (Polyketides); 0 (RNA, Fungal); 0 (emerimidine)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170828
[Lr] Data última revisão:
170828
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170301
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0172848


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[PMID]:27922746
[Au] Autor:Brighenti FL; Salvador MJ; Gontijo AVL; Delbem ACB; Delbem ÁCB; Soares CP; de Oliveira MAC; Girondi CM; Koga-Ito CY
[Ad] Endereço:Faculty of Dentistry, Univ. Estadual Paulista/UNESP, Araraquara, R. Humaitá, 1680, Araraquara, SP 14801-903, Brazil.
[Ti] Título:Plant extracts: initial screening, identification of bioactive compounds and effect against Candida albicans biofilms.
[So] Source:Future Microbiol;12:15-27, 2017 01.
[Is] ISSN:1746-0921
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:AIM: This study screened plants from Brazilian Pantanal for Candida albicans antibiofilm activity. MATERIAL & METHODS: Sixty extracts were obtained from ten plants using different extraction methods. Antifungal activity was assessed. Effects on biofilm inhibition and disruption and cytotoxicity were also evaluated. The most active extract was chemically characterized. RESULTS: Buchenavia tomentosa ethanolic extract showed noticeable antifungal activity and was selected for biofilm experiments. Subinhibitory concentration of extract inhibited fungal adhesion. Maximum killing reached 90% of C. albicans cells in suspension and 65% of cells in biofilms. The active extract was noncytotoxic. Chemical characterization showed the presence of phenols. Ellagic and gallic acids showed activity on C. albicans. CONCLUSION: B. tomentosa extract and its isolated compound, ellagic acid, presented antibiofilm activity and low toxicity.
[Mh] Termos MeSH primário: Antifúngicos/farmacologia
Biofilmes/efeitos dos fármacos
Candida albicans/efeitos dos fármacos
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Brasil
Células CACO-2
Combretaceae/química
Ácido Elágico/farmacologia
Ácido Gálico/farmacologia
Seres Humanos
Fenóis/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antifungal Agents); 0 (Phenols); 0 (Plant Extracts); 19YRN3ZS9P (Ellagic Acid); 632XD903SP (Gallic Acid)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170821
[Lr] Data última revisão:
170821
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161207
[St] Status:MEDLINE
[do] DOI:10.2217/fmb-2016-0094


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[PMID]:28862820
[Au] Autor:Pelozo A; Boeger MRT; Sereneski-de-Lima C; Soffiatti P
[Ti] Título:Leaf morphological strategies of seedlings and saplings of Rhizophora mangle (Rhizophoraceae), Laguncularia racemosa (Combretaceae) and Avicennia schaueriana (Acanthaceae) from Southern Brazil.
[So] Source:Rev Biol Trop;64(1):305-17, 2016 03.
[Is] ISSN:0034-7744
[Cp] País de publicação:Costa Rica
[La] Idioma:eng
[Ab] Resumo:The initial phase of a plant life cycle is a short and critical period, when individuals are more vulnerable to environmental factors. The morphological and anatomical study of seedlings and saplings leaf type enables the understanding of species strategies of fundamental importance in their establishment and survival. The objective of this study was to analyze the structure of seedlings and saplings leaf types of three mangrove species, Avicennia schaueriana, Laguncularia racemosa, Rhizophora mangle, to understand their early life adaptive strategies to the environment. A total of 30 fully expanded cotyledons (A. schaueriana and L. racemosa), 30 leaves of seedlings, and 30 leaves of saplings of each species were collected from a mangrove area in Guaratuba Bay, Paraná State, Brazil. Following standard methods, samples were prepared for morphological (leaf dry mass, density, thickness) and anatomical analysis (epidermis and sub-epidermal layers, stomata types, density of salt secretion glands, palisade and spongy parenchyma thickness). To compare leaf types among species one-way ANOVA and Principal Component Analysis were used, while Cluster Analysis evaluated differences between the species. We observed significant structural differences among species leaf types. A. schaueriana showed the thickest cotyledons, while L. racemosa presented a dorsiventral structure. Higher values of the specific leaf area were observed for seedlings leaves of A. schaueriana, cotyledons of L. racemosa and saplings leaves of A. schaueriana and R. mangle. Leaf density was similar to cotyledons and seedlings leaves in A. schaueriana and L. racemosa, while R. mangle had seedlings leaves denser than saplings. A. schaueriana and R. mangle showed hypostomatic leaves, while L. racemosa amphistomatic; besides, A. chaueriana showed diacytic stomata, while L. racemosa anomocytic, and R. mangle ciclocytic. Seedling leaves were thicker in R. mangle (535 µm) and L. racemosa (520 µm) than in A. schaueriana (470.3 µm); while saplings leaves were thicker in L. racemosa (568.3 µm) than in A. schaueriana seedlings (512.4 µm) and R. mangle (514.6 µm). Besides, seedlings leaves palisade parenchyma showed increasing thickness in L. racemosa (119.2 µm) < A. schaueriana (155.5 µm) < R. mangle (175.4 µm); while in saplings leaves as follows R. mangle (128.4 µm) < A. schaueriana (183.4 µm) < L. racemosa (193.9 µm). Similarly, seedlings leaves spongy parenchyma thickness values were as follows A. schaueriana (182.6 µm) = R. mangle (192.8 µm) < L. racemosa (354.4 µm); while in saplings were A. schaueriana (182.6 µm) = R. mangle (187.3 µm) < L. racemosa (331.3 µm). The analyzed traits, in different combinations, represent morphological adjustments of leaf types to reduce water loss, eliminate salt excess, increase the absorption of light, allowing a higher efficiency on the maintenance of physiological processes in this initial growth stage.
[Mh] Termos MeSH primário: Avicennia/fisiologia
Combretaceae/fisiologia
Folhas de Planta/fisiologia
Rhizophoraceae/fisiologia
Plântulas/fisiologia
[Mh] Termos MeSH secundário: Adaptação Biológica
Avicennia/classificação
Avicennia/ultraestrutura
Brasil
Combretaceae/classificação
Combretaceae/ultraestrutura
Microscopia Eletrônica de Varredura
Folhas de Planta/ultraestrutura
Rhizophoraceae/classificação
Rhizophoraceae/ultraestrutura
Plântulas/ultraestrutura
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171003
[Lr] Data última revisão:
171003
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170902
[St] Status:MEDLINE


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[PMID]:28476711
[Au] Autor:Al-Taweel AM; Perveen S; Fawzy GA; Mehmood R; Khan A; Khan SI
[Ad] Endereço:Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Kingdom of Saudi Arabia.
[Ti] Título:New ellagic acid derivative from the fruits of heat-tolerant plant Conocarpus lancifolius Engl. and their anti-inflammatory, cytotoxic, PPAR agonistic activities.
[So] Source:Pak J Pharm Sci;29(5 Suppl):1833-1837, 2016 Sep.
[Is] ISSN:1011-601X
[Cp] País de publicação:Pakistan
[La] Idioma:eng
[Ab] Resumo:Conocarpus lancifolius (Combretaceae), is distributed in Riyadh, Saudi Arabia. It is a heat-tolerant Saudi medicinal plant, demonstrates prominent antidiabetic potential and the fruit extract fruits showed cytotoxicity against MRC-5 cancer cell line, as well as prominent antiprotozoal and antibacterial activities. The objective of this study is to isolate the compounds and evaluate the anti-inflammatory, cytotoxic, PPAR agonistic and antioxidant activities of extracts and pure constituents from C. lancifolius. A new trimethoxyellagic acid derivative 1 and two compounds, kaempferol 3-O-rutinoside 2 and ß-sitosterol glucoside 3 were isolated from the fruits of Conocarpus lancifolius, a heat-tolerant plant. Compound 2 showed strong dual activation for PPARα and PPARγ with 2.6 fold increment in PPARα activity, while 2.2 fold increment in PPARγ at 25µ/ml. This is first report on isolation and screening of different biological activities of extract and pure constituents from fruits of C. lancifolius.
[Mh] Termos MeSH primário: Anti-Inflamatórios/farmacologia
Antineoplásicos Fitogênicos/farmacologia
Combretaceae/química
Ácido Elágico/isolamento & purificação
Receptores Ativados por Proliferador de Peroxissomo/agonistas
[Mh] Termos MeSH secundário: Adaptação Fisiológica
Espectroscopia de Ressonância Magnética Nuclear de Carbono-13
Linhagem Celular Tumoral
Combretaceae/fisiologia
Ácido Elágico/farmacologia
Temperatura Alta
Seres Humanos
Espectroscopia de Prótons por Ressonância Magnética
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents); 0 (Antineoplastic Agents, Phytogenic); 0 (Peroxisome Proliferator-Activated Receptors); 19YRN3ZS9P (Ellagic Acid)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170626
[Lr] Data última revisão:
170626
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170507
[St] Status:MEDLINE


  9 / 146 MEDLINE  
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[PMID]:27615869
[Au] Autor:Santos JC; Moraes GJ
[Ad] Endereço:Departamento de Fitossanidade, FCAV-UNESP, 14884-900 Jaboticabal, São Paulo, Brazil.; Email: jandir_jc@hotmail.com.
[Ti] Título:A new species of Leioseius (Acari: Ascidae) from Brazil, redescription of Leioseius basis and a key for separation of the world species of the genus.
[So] Source:Zootaxa;4158(1):52-64, 2016 Aug 26.
[Is] ISSN:1175-5334
[Cp] País de publicação:New Zealand
[La] Idioma:eng
[Ab] Resumo:Leioseius Berlese is known in South America only from one especies described from Chile. Leioseius cananeiensis n. sp. is described based on the morphology of adult females found in association with barnacles (Crustacea, Cirripedia) on roots of Laguncularia racemosa (L.) (Combretaceae) collected in Cananéia, São Paulo State, Brazil. Leioseius basis Karg is redescribed based on the holotype female, one paratype female and two sparatype males. A key for the separation of females of the 19 recognisable world Leioseius species is provided.
[Mh] Termos MeSH primário: Ácaros/classificação
[Mh] Termos MeSH secundário: Estruturas Animais/anatomia & histologia
Estruturas Animais/crescimento & desenvolvimento
Animais
Tamanho Corporal
Brasil
Combretaceae/parasitologia
Ecossistema
Feminino
Masculino
Ácaros/anatomia & histologia
Ácaros/crescimento & desenvolvimento
Tamanho do Órgão
Raízes de Plantas/parasitologia
Thoracica/parasitologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170323
[Lr] Data última revisão:
170323
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160913
[St] Status:MEDLINE
[do] DOI:10.11646/zootaxa.4158.1.2


  10 / 146 MEDLINE  
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[PMID]:27600275
[Au] Autor:Reinert F; de Pinho CF; Ferreira MA
[Ad] Endereço:Laboratório de Fisiologia Vegetal, Instituto de Biologia, Universidade Federal do Rio de Janeiro, Brazil; Programa de Pós-graduação em Biotecnologia Vegetal, Universidade Federal do Rio de Janeiro, Brazil.
[Ti] Título:Diagnosing the level of stress on a mangrove species (Laguncularia racemosa) contaminated with oil: A necessary step for monitoring mangrove ecosystems.
[So] Source:Mar Pollut Bull;113(1-2):94-99, 2016 Dec 15.
[Is] ISSN:1879-3363
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Monitoring the effects of pollution on mangrove vegetation is a challenge. A specific study using an oil spill simulation on mangrove species was conducted to address this challenge. We tested the effectiveness of the chlorophyll a fluorescence kinetics as a fast and robust method to diagnose the vitality of Laguncularia racemosa. We used L. racemosa plants contaminated with marine fuel oil in mangrove microcosm models. Several parameters of the JIP-test were capable of detecting the impairment of the photosynthetic function prior to the visual manifestation of symptoms in response to oil contamination. The results support the use of the chlorophyll fluorescence transient as a reliable, fast and easy to apply diagnostic method for evaluating oil-impacted mangroves. To the best of our knowledge, it is the first time that consistent data showing photosynthetic impairment in response to oil contamination is shown for a mangrove tree species.
[Mh] Termos MeSH primário: Combretaceae/efeitos dos fármacos
Monitoramento Ambiental/métodos
Óleos Combustíveis/toxicidade
Poluição por Petróleo/análise
Fotossíntese/efeitos dos fármacos
Poluentes do Solo/toxicidade
Árvores/efeitos dos fármacos
[Mh] Termos MeSH secundário: Brasil
Clorofila/metabolismo
Combretaceae/crescimento & desenvolvimento
Combretaceae/metabolismo
Ecossistema
Óleos Combustíveis/análise
Modelos Teóricos
Poluentes do Solo/análise
Árvores/crescimento & desenvolvimento
Árvores/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Fuel Oils); 0 (Soil Pollutants); 1406-65-1 (Chlorophyll); YF5Q9EJC8Y (chlorophyll a)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160908
[St] Status:MEDLINE



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