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[PMID]:28969626
[Au] Autor:Lopez HL; Habowski SM; Sandrock JE; Raub B; Kedia A; Bruno EJ; Ziegenfuss TN
[Ad] Endereço:Division of Sports Nutrition and Exercise Science, The Center for Applied Health Sciences, 4302 Allen Road, Suite 120, Stow, OH, 44224, USA. HL@appliedhealthsciences.org.
[Ti] Título:Effects of dietary supplementation with a standardized aqueous extract of Terminalia chebula fruit (AyuFlex ) on joint mobility, comfort, and functional capacity in healthy overweight subjects: a randomized placebo-controlled clinical trial.
[So] Source:BMC Complement Altern Med;17(1):475, 2017 Oct 02.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Joint and connective tissue integrity, comfort and function are paramount to optimal performance in exercise, recreational and occupational activities. The fruit of Terminalia chebula has been used extensively in various traditional health systems for different ailments, with additional preclinical and clinical data demonstrating antioxidant and anti-inflammatory potential. The aim of this study was to evaluate the effects of a standardized aqueous extract of Terminalia chebula fruit (AyuFlex®) dietary supplementation on joint mobility, comfort, and functional capacity in healthy overweight subjects. METHODS: One-hundred and five (105) overweight, apparently healthy male and female subjects (35-70 years of age) were pre-screened and randomized to one of three groups for 84 days: placebo, AyuFlex1 (250 mg twice daily) or AyuFlex2 (500 mg twice daily) in a randomized, double-blind, placebo-controlled design. A two-week placebo lead-in period was used to improve data quality/validity. All subjects had no knee joint discomfort at rest, but experienced knee joint discomfort only with activity/exercise of at least 30 on 100 mm Visual Analog Scale (VAS). Primary outcome measures included symptoms of joint health and function as measured by modified-Knee Injury & Osteoarthritis Outcomes Score (mKOOS) global & modified-Western Ontario and McMaster Universities Arthritis Index (mWOMAC) subscales (discomfort, stiffness and function). Secondary outcomes included VAS questionnaires on overall/whole-body joint health, low back health, knee mobility, willingness and ability to exercise, 6-min walk test for distance and range of motion (ROM) of pain-free knee flexion/extension. Tertiary outcome measures included inflammatory (high sensitivity C-reactive protein (hsCRP), tumor necrosis factor (TNF)-α) and extracellular matrix (ECM)/Connective Tissue (COMP) biomarkers, and safety (vital signs and blood markers) & tolerability (Adverse Event (AE)/ side effect profiles). RESULTS: Compared to placebo, at day 84 AyuFlex® treatment significantly: 1) improved mKOOS global scores in AyuFlex1 + AyuFlex2 (P = 0.023), and improved total and physical function subscale of mWOMAC relative to baseline, 2) improved VAS scores for Knee Discomfort with activity/exercise in AyuFlex1 + AyuFlex2 (P = 0.001) relative to baseline, 3) improved VAS scores for whole-body joint function in AyuFlex1 + AyuFlex2 (P < 0.029) relative to baseline, 4) improved VAS score for decreased knee joint soreness following leg extension challenge for AyuFlex1 (P = 0.022) and AyuFlex2 (P = 0.043) relative to baseline, 5) improved 6-min walk performance distance covered (P = 0.047) and VAS discomfort (P = 0.026) post-6 min walk in AyuFlex1 + AyuFlex2 relative to baseline, 6) and tended to decrease COMP levels in AyuFlex1 + AyuFLex2 (P = 0.104) relative to baseline. All biomarkers of safety remained within normative limits during the study. Low back health tended to improve in the AyuFlex1 and AyuFlex2 group, but failed to reach significance relative to placebo group. CONCLUSIONS: AyuFlex® improved mKOOS global scores, knee joint discomfort with activity/exercise, 6-min walk test distance covered and discomfort post-6 min walk test, overall whole-body joint function, knee soreness following leg extension resistance exercise in a healthy, overweight population, without AE. Differences between 250 mg/BID and 500 mg/BID were non-significant for most of the outcome measures, validating the efficacy of the lower dose. TRIAL REGISTRATION: ClinicalTrials.gov identifier NCT02589249 ; October 26, 2015.
[Mh] Termos MeSH primário: Artralgia/tratamento farmacológico
Frutas/química
Extratos Vegetais/uso terapêutico
Amplitude de Movimento Articular/efeitos dos fármacos
Terminalia/química
[Mh] Termos MeSH secundário: Adulto
Idoso
Proteína C-Reativa/análise
Teste de Esforço/efeitos dos fármacos
Feminino
Seres Humanos
Masculino
Meia-Idade
Sobrepeso
Extratos Vegetais/administração & dosagem
Extratos Vegetais/farmacologia
Fator de Necrose Tumoral alfa/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Plant Extracts); 0 (Tumor Necrosis Factor-alpha); 9007-41-4 (C-Reactive Protein)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171027
[Lr] Data última revisão:
171027
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:171004
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-1977-8


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[PMID]:28724416
[Au] Autor:Lee KW; Nam MH; Lee HR; Hong CO; Lee KW
[Ad] Endereço:Department of Biotechnology, Korea University Graduate School, Seoul, 02841, Republic of Korea.
[Ti] Título:Protective effects of chebulic acid on alveolar epithelial damage induced by urban particulate matter.
[So] Source:BMC Complement Altern Med;17(1):373, 2017 Jul 19.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Chebulic acid (CA) isolated from T. chebula, which has been reported for treating asthma, as a potent anti-oxidant resources. Exposure to ambient urban particulate matter (UPM) considered as a risk for cardiopulmonary vascular dysfunction. To investigate the protective effect of CA against UPM-mediated collapse of the pulmonary alveolar epithelial (PAE) cell (NCI-H441), barrier integrity parameters, and their elements were evaluated in PAE. METHODS: CA was acquired from the laboratory previous reports. UPM was obtained from the National Institutes of Standards and Technology, and these were collected in St. Louis, MO, over a 24-month period and used as a standard reference. To confirm the protection of PAE barrier integrity, paracellular permeability and the junctional molecules were estimated with determination of transepithelial electrical resistance, Western Blotting, RT-PCR, and fluorescent staining. RESULTS: UPM aggravated the generation of reactive oxygen species (ROS) in PAE and also decreased mRNA and protein levels of junction molecules and barrier integrity in NCI-H441. However, CA repressed the ROS in PAE, also improved barrier integrity by protecting the junctional parameters in NCI-H411. CONCLUSIONS: These data showed that CA resulted in decreased UPM-induced ROS formation, and the protected the integrity of the tight junctions against UPM exposure to PAE barrier.
[Mh] Termos MeSH primário: Células Epiteliais Alveolares/efeitos dos fármacos
Benzopiranos/farmacologia
Inflamação/prevenção & controle
Material Particulado/efeitos adversos
Fitoterapia
Terminalia/química
Junções Íntimas/efeitos dos fármacos
[Mh] Termos MeSH secundário: Poluição do Ar/efeitos adversos
Células Epiteliais Alveolares/metabolismo
Células Epiteliais Alveolares/patologia
Antiasmáticos/farmacologia
Anti-Inflamatórios/farmacologia
Anti-Inflamatórios/uso terapêutico
Antioxidantes/farmacologia
Antioxidantes/uso terapêutico
Linhagem Celular
Citocinas/metabolismo
Seres Humanos
Inflamação/metabolismo
Pulmão/citologia
Pulmão/efeitos dos fármacos
Pulmão/metabolismo
Pulmão/patologia
Missouri
Estresse Oxidativo/efeitos dos fármacos
Permeabilidade
Extratos Vegetais/farmacologia
Extratos Vegetais/uso terapêutico
RNA Mensageiro/metabolismo
Espécies Reativas de Oxigênio/metabolismo
Proteínas de Junções Íntimas/genética
Proteínas de Junções Íntimas/metabolismo
Junções Íntimas/metabolismo
Junções Íntimas/patologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Asthmatic Agents); 0 (Anti-Inflammatory Agents); 0 (Antioxidants); 0 (Benzopyrans); 0 (Cytokines); 0 (Particulate Matter); 0 (Plant Extracts); 0 (RNA, Messenger); 0 (Reactive Oxygen Species); 0 (Tight Junction Proteins); 0 (chebulic acid)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170901
[Lr] Data última revisão:
170901
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170721
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-1870-5


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[PMID]:28638863
[Au] Autor:Shen YC; Juan CW; Lin CS; Chen CC; Chang CL
[Ad] Endereço:National Research Institute of Chinese Medicine, Ministry of Health and Welfare, Taipei City, Taiwan (R.O.C.).
[Ti] Título:NEUROPROTECTIVE EFFECT OF EXTRACTS AND ELLAGIC ACID IN PC12 CELLS.
[So] Source:Afr J Tradit Complement Altern Med;14(4):22-30, 2017.
[Is] ISSN:2505-0044
[Cp] País de publicação:Nigeria
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Alzheimer's disease (AD) is one of the common neurodegenerative disorders among elderly. The purpose of this study was to determine the neuroprotective effect and mechanisms of action underlying the extracts and ellagic acid by using beta-amyloid (Aß )-induced cell toxicity in an undifferentiated pheochromocytoma (PC12) cell line. MATERIALS AND METHODS: The extracts were prepared using the methanol, water, and 95% ethanol. Specifically, the ellagic acid was obtained in our laboratory. Assays including cell toxicity and changes in intracellular reactive oxygen species (ROS) and calcium level were evaluated to examine the neuroprotective effects and mechanisms of the extracts and ellagic acid. RESULTS: The methanolic and water extracts of and ellagic acid exhibited the strongest neuroprotective activity against Aß -induced PC12 cell damages at 0.5-5.0 µg/ml. The ellagic acid also exhibited partial neuroprotective activity against H O -induced PC12 cell damages at 0.5-5.0 µg/ml. The methanolic and water extracts of and ellagic acid protected PC12 cells from Aß -mediated cell damages and enhanced cell viability thorough two key mechanisms by: (1) inhibiting ROS production and (2) reducing calcium ion influx. CONCLUSION: The represents a promising plant-source as medicine in the application for the treatment of AD. Further investigation focusing on the active component of extracts e.g., ellagic acid is crucial to verify the neuroprotective efficacy and mechanisms .
[Mh] Termos MeSH primário: Ácido Elágico/farmacologia
Fármacos Neuroprotetores/farmacologia
Extratos Vegetais/farmacologia
Terminalia/química
[Mh] Termos MeSH secundário: Animais
Sobrevivência Celular/efeitos dos fármacos
Ácido Elágico/isolamento & purificação
Peróxido de Hidrogênio/toxicidade
Neurônios/citologia
Neurônios/efeitos dos fármacos
Neurônios/metabolismo
Fármacos Neuroprotetores/isolamento & purificação
Células PC12
Extratos Vegetais/isolamento & purificação
Ratos
Espécies Reativas de Oxigênio/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Neuroprotective Agents); 0 (Plant Extracts); 0 (Reactive Oxygen Species); 19YRN3ZS9P (Ellagic Acid); BBX060AN9V (Hydrogen Peroxide)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170623
[St] Status:MEDLINE
[do] DOI:10.21010/ajtcam.v14i4.3


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[PMID]:28562631
[Au] Autor:Bag A; Chattopadhyay RR
[Ad] Endereço:Agricultural and Ecological Research Unit, Indian Statistical Institute, Kolkata, India.
[Ti] Título:Synergistic antibiofilm efficacy of a gallotannin 1,2,6-tri-O-galloyl-ß-D-glucopyranose from Terminalia chebula fruit in combination with gentamicin and trimethoprim against multidrug resistant uropathogenic Escherichia coli biofilms.
[So] Source:PLoS One;12(5):e0178712, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In recent years the emergence of multiple drug resistance microbes has become a global public health problem. The aim of the present investigation was to evaluate possible antibiofilm efficacy of a gallotannin 1,2,6-tri-O-galloyl-ß-D-glucopyranose from Terminalia chebula fruits alone and in combination with gentamicin and trimethoprim against preformed biofilms of multidrug-resistant (MDR) uropathogenic E. coli isolates using microbroth dilution, checkerboard titration and kill kinetics methods. Test gallotannin showed > 50% antibiofilm efficacy after 24 h when administered alone whereas gentamicin and trimethoprim failed to do so. But in combination, test gallotannin/gentamicin and test gallotannin/trimethoprim showed 71.24±6.75% and 93.4±8.46% antibiofilm activity respectively. On the basis of FICI values, test gallotannin/gentamicin showed synergistic interactions against 71.42% and test gallotannin/trimethoprim against 85.71% biofilm forming test bacterial isolates. Kill-kinetics study confirmed their synergistic interactions. Thus, gentamicin and trimethoprim in combination with test gallotannin may have potential for treatment of urinary tract infections caused by biofilm forming MDR uropathogenic E. coli.
[Mh] Termos MeSH primário: Biofilmes
Farmacorresistência Bacteriana Múltipla/efeitos dos fármacos
Escherichia coli/efeitos dos fármacos
Gentamicinas/farmacologia
Taninos Hidrolisáveis/química
Terminalia/química
Trimetoprima/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (1,2,6-tri-O-galloyl-beta-D-glucopyranose); 0 (Gentamicins); 0 (Hydrolyzable Tannins); AN164J8Y0X (Trimethoprim)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170926
[Lr] Data última revisão:
170926
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170601
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0178712


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[PMID]:28534052
[Au] Autor:Parameswari R; Rao KA; Manigandan P; Vickram AS; Archana A; Sridharan TB
[Ad] Endereço:Department of Industrial Biotechnology, School of Biosciences and Technology, VIT University, Vellore, India.
[Ti] Título:Tea polyphenol-T. arjuna bark as sperm antioxidant extender in infertile smokers.
[So] Source:Cryo Letters;38(2):95-99, 2017 Mar/Apr.
[Is] ISSN:0143-2044
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Antioxidants protect spermatozoa against lipid peroxidation during freezing. OBJECTIVE: The study is designed to elucidate the suitable extender to preserve infertile semen of smokers against ROS damage using natural Tea polyphenol (T. arjuna bark extract). MATERIALS AND METHODS: Forty-two infertile subjects with smoking habit and 28 fertile subjects without smoking habit were considered for the study. Four semen extenders including our naturally derived antioxidant component were prepared and used to preserve semen sample from the study subjects for a period of one month. Standard semen parameters, biochemical and sperm DNA damage marker with inhibition were measured before and after cryopreservation. RESULTS: The motility and morphology of sperm cells were maintained better in E4 extender, and DNA damage is reduced. CONCLUSION: Extender recipe with natural antioxidants (E3 and E4) was found to be apt for infertile semen preservation.
[Mh] Termos MeSH primário: Criopreservação/métodos
Infertilidade Masculina
Polifenóis/farmacologia
Preservação do Sêmen/métodos
Espermatozoides
Terminalia
[Mh] Termos MeSH secundário: Antioxidantes/farmacologia
Crioprotetores/farmacologia
Dano ao DNA/efeitos dos fármacos
Seres Humanos
Infertilidade Masculina/etiologia
Infertilidade Masculina/patologia
Peroxidação de Lipídeos/efeitos dos fármacos
Masculino
Casca de Planta
Fumar/efeitos adversos
Motilidade Espermática/efeitos dos fármacos
Espermatozoides/efeitos dos fármacos
Espermatozoides/patologia
Chás de Ervas
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Cryoprotective Agents); 0 (Polyphenols); 0 (Teas, Herbal)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170724
[Lr] Data última revisão:
170724
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170524
[St] Status:MEDLINE


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[PMID]:28492713
[Au] Autor:Ali Khan MS; Nazan S; Mat Jais AM
[Ad] Endereço:Department of Pharmacology & Toxicology, College of Pharmacy, Al Jouf University, Sakakah, Al-Jouf Province, Kingdom of Saudi Arabia.
[Ti] Título:FLAVONOIDS AND ANTI-OXIDANT ACTIVITY MEDIATED GASTROPROTECTIVE ACTION OF LEATHERY MURDAH, TERMINALIA CORIACEA (ROXB.) WIGHT & ARN. LEAF METHANOLIC EXTRACT IN RATS.
[So] Source:Arq Gastroenterol;54(3):183-191, 2017 Jul-Sept.
[Is] ISSN:1678-4219
[Cp] País de publicação:Brazil
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Leathery Murdah, Terminalia coriacea (Roxb.) Wight & Arn. from family Combretaceae is used in Ayurveda and Siddha traditional systems of medicine to heal ulcers. OBJECTIVE: The present study was conducted to assess the gastroprotective effect and understand the fundamental mechanism of action of Leathery Murdah, Terminalia coriacea (Roxb.) Wight & Arn. Leaf Methanolic Extract. METHODS: The test extract was screened for anti-ulcer activity by Aspirin induced ulcerogenesis in pyloric ligation and ethanol induced gastric ulcers at three doses - 125, 250, and 500 mg/kg, p.o. using Ranitidine 50 mg/kg and Misoprostol 100 µg/kg as standard drug in respective models. Seven parameters were carefully examined, that is, ulcer index, total protein, mucin, catalase, malondialdehyde, and superoxide dismutase levels and histopathology. High Performance Liquid Chromatographic - Ultra Violet profiling and Liquid Chromatography - Mass Spectral analysis of crude Terminalia coriacea leaves methanolic extract were carried out as a part of chemical characterization to identify bioactive compounds. RESULTS: All the test doses exhibited significant gastroprotective function, particularly the higher doses demonstrated improved action. The results revealed a significant increase in the levels of catalase, superoxide dismutase, and Mucin with reduction in ulcer index, the levels of total protein, and malondialdehyde. Histopathological observations also illustrated the gastroprotective effect of Terminalia coriacea leaves methanolic extract. CONCLUSION: Terminalia coriacea leaves methanolic extract exhibited strong anti-oxidant and anti-secretory activities mediated gastroprotection besides inducing the gastric mucosal production. The observed pharmacological response can be attributed to the flavonoidal compounds namely - Quercetin-3-O-rutinoside, Luteolin-7-O-glucoside, Myricetin hexoside, Quercetin-3-O-glucoside, Isorhamnetin-3-O-rhamnosylglucoside and Isorhamnetin-3-O-glucoside identified in the extract for the first time with High Performance Liquid Chromatographic - Ultra Violet and Liquid Chromatography - Mass Spectral analysis.
[Mh] Termos MeSH primário: Antiulcerosos/administração & dosagem
Extratos Vegetais/administração & dosagem
Úlcera Gástrica/tratamento farmacológico
Terminalia/química
[Mh] Termos MeSH secundário: Animais
Anti-Inflamatórios não Esteroides
Aspirina
Modelos Animais de Doenças
Relação Dose-Resposta a Droga
Mucosa Gástrica/efeitos dos fármacos
Masculino
Ratos
Ratos Wistar
Úlcera Gástrica/induzido quimicamente
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Inflammatory Agents, Non-Steroidal); 0 (Anti-Ulcer Agents); 0 (Plant Extracts); R16CO5Y76E (Aspirin)
[Em] Mês de entrada:1711
[Cu] Atualização por classe:171106
[Lr] Data última revisão:
171106
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170512
[St] Status:MEDLINE


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[PMID]:28427461
[Au] Autor:Mohieldin EAM; Muddathir AM; Mitsunaga T
[Ad] Endereço:Faculty of Pharmacy, University of Science and Technology, Omdurman, Sudan.
[Ti] Título:Inhibitory activities of selected Sudanese medicinal plants on Porphyromonas gingivalis and matrix metalloproteinase-9 and isolation of bioactive compounds from Combretum hartmannianum (Schweinf) bark.
[So] Source:BMC Complement Altern Med;17(1):224, 2017 Apr 20.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Periodontal diseases are one of the major health problems and among the most important preventable global infectious diseases. Porphyromonas gingivalis is an anaerobic Gram-negative bacterium which has been strongly implicated in the etiology of periodontitis. Additionally, matrix metalloproteinases-9 (MMP-9) is an important factor contributing to periodontal tissue destruction by a variety of mechanisms. The purpose of this study was to evaluate the selected Sudanese medicinal plants against P. gingivalis bacteria and their inhibitory activities on MMP-9. METHODS: Sixty two methanolic and 50% ethanolic extracts from 24 plants species were tested for antibacterial activity against P. gingivalis using microplate dilution assay method to determine the minimum inhibitory concentration (MIC). The inhibitory activity of seven methanol extracts selected from the 62 extracts against MMP-9 was determined by Colorimetric Drug Discovery Kit. In search of bioactive lead compounds, Combretum hartmannianum bark which was found to be within the most active plant extracts was subjected to various chromatographic (medium pressure liquid chromatography, column chromatography on a Sephadex LH-20, preparative high performance liquid chromatography) and spectroscopic methods (liquid chromatography-mass spectrometry, Nuclear Magnetic Resonance (NMR)) to isolate and characterize flavogalonic acid dilactone and terchebulin as bioactive compounds. RESULTS: About 80% of the crude extracts provided a MIC value ≤4 mg/ml against bacteria. The extracts which revealed the highest potency were: methanolic extracts of Terminalia laxiflora (wood; MIC = 0.25 mg/ml) followed by Acacia totrtilis (bark), Ambrosia maritima (aerial part), Argemone mexicana (seed), C. hartmannianum (bark), Terminalia brownii (wood) and 50% ethanolic extract of T. brownii (bark) with MIC values of 0.5 mg/ml. T. laxiflora (wood) and C. hartmannianum (bark) which belong to combretaceae family showed an inhibitory activity over 50% at the concentration of 10 µg/ml against MMP-9. Additionally, MMP-9 was significantly inhibited by terchebulin with IC value of 6.7 µM. CONCLUSIONS: To the best of our knowledge, flavogalonic acid dilactone and terchebulin were isolated from C. hartmannianium bark for the first time in this study. Because of terchebulin and some crude extracts acting on P. gingivalis bacteria and MMP-9 enzyme that would make them promising natural preference for preventing and treating periodontal diseases.
[Mh] Termos MeSH primário: Antibacterianos/farmacologia
Combretum/química
Metaloproteinase 9 da Matriz/metabolismo
Doenças Periodontais
Extratos Vegetais/farmacologia
Plantas Medicinais
Porphyromonas gingivalis/efeitos dos fármacos
[Mh] Termos MeSH secundário: Acacia
Ambrosia
Argemone
Taninos Hidrolisáveis/isolamento & purificação
Taninos Hidrolisáveis/farmacologia
Lactonas/isolamento & purificação
Lactonas/farmacologia
Medicina Tradicional Africana
Doenças Periodontais/tratamento farmacológico
Doenças Periodontais/microbiologia
Casca de Planta/química
Extratos Vegetais/química
Sudão
Terminalia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Hydrolyzable Tannins); 0 (Lactones); 0 (Plant Extracts); 0 (terchebulin); EC 3.4.24.35 (Matrix Metalloproteinase 9)
[Em] Mês de entrada:1707
[Cu] Atualização por classe:170731
[Lr] Data última revisão:
170731
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170422
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-1735-y


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[PMID]:28300045
[Au] Autor:Sushma R; Sathe TT; Farias A; Sanyal PK; Kiran S
[Ad] Endereço:Department of Prosthodontics and Crown and Bridge, School of Dental Sciences, Krishna Institute of Medical Sciences and Deemed University, Karad, Maharashtra, India.
[Ti] Título:"Nature cures:" An alternative herbal formulation as a denture cleanser.
[So] Source:Ann Afr Med;16(1):6-12, 2017 Jan-Mar.
[Is] ISSN:0975-5764
[Cp] País de publicação:India
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Candida albicans is one of the microorganisms which harbor the oral cavity, especially in elderly. However, the incidence of existence of this increases in patients using removable dental prosthesis. There is therefore a need to test the anticandidal efficacy of these cost-effective, easily available products to be used as routine denture cleansers. AIM AND OBJECTIVES: (1) To evaluate antifungal properties of triphala churna on the heat cure denture base material. (2) To evaluate the antifungal effect of chlorhexidine gluconate on the heat cure denture base material. (3) To compare the antifungal effect of triphala churna and chlorhexidine gluconate with a control. (4) To evaluate which among triphala churna and chlorhexidine gluconate has a better antifungal property on the heat cure denture base material. MATERIALS AND METHODS: Study population consisted of sixty dentures wearers from those attending the Outpatient Department of Prosthodontics of the School of Dentistry, Krishna Institute of Medical Sciences Deemed University, Karad. Swabs were collected from the dentures before and after the use of triphala and chlorhexidine. The swabs were cultured on Sabouraud dextrose agar and the total Candida counts were determined. CONCLUSION: Triphala as an antifungal is shown to have more efficacy than the conventional chlorhexidine mouthwash. Résumé Arrière-plan: Candida albicans est l'un des micro-organismes qui abritent la cavité buccale surtout chez les personnes âgées. Cependant, l'incidence de l'existence de cette augmentation chez les patients utilisant des prothèses dentaires amovibles. Il est donc nécessaire de tester l'efficacité anticancédique de ces produits rentables et faciles à utiliser pour être utilisés comme nettoyants de routine pour prothèses dentaires. Buts et Objectifs: (1) Évaluer les propriétés antifongiques de Triphala churna sur le matériau de base de la prothèse thermo-durcissable. (2) Évaluer l'effet antifongique du gluconate de chlorhexidine sur le matériau de base de la prothèse thermo-durcissable. (3) Comparer l'effet antifongique de Triphala churna et du gluconate de chlorhexidine avec un témoin. (4) Évaluer lequel parmi Triphala churna et le gluconate de chlorhexidine a une meilleure propriété antifongique sur le matériel de base de la prothèse de durcissement à chaud. Matériaux et Méthode: La population de l'étude était constituée de soixante porteurs de prothèses dentaires de ceux qui fréquentaient le Département de Prosthodontie de l'École des Sciences Dentaires de l'Institut Krishna des Sciences Médicales de l'Université de Karad. Des prélèvements ont été effectués sur les prothèses avant et après l'utilisation de Triphala et de chlorhexidine. On a cultivé les écouvillons sur de l'agar Sabouraud dextrose et on a déterminé le nombre total de candida. CONCLUSION: Triphala comme un anti fongique est démontré pour avoir plus d'efficacité que le lavage de la bouche classique chlorhexidine.
[Mh] Termos MeSH primário: Anti-Infecciosos Locais/uso terapêutico
Antifúngicos/uso terapêutico
Candida albicans/efeitos dos fármacos
Candidíase/tratamento farmacológico
Clorexidina/análogos & derivados
Higienizadores de Dentadura/uso terapêutico
Frutas
Extratos Vegetais/uso terapêutico
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Anti-Infecciosos Locais/farmacologia
Antifúngicos/farmacologia
Candida albicans/isolamento & purificação
Clorexidina/farmacologia
Clorexidina/uso terapêutico
Contagem de Colônia Microbiana
Higienizadores de Dentadura/farmacologia
Prótese Parcial Removível/microbiologia
Seres Humanos
Meia-Idade
Phyllanthus emblica/química
Extratos Vegetais/farmacologia
Preparações de Plantas/uso terapêutico
Fatores Socioeconômicos
Terminalia/química
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL
[Nm] Nome de substância:
0 (Anti-Infective Agents, Local); 0 (Antifungal Agents); 0 (Denture Cleansers); 0 (Plant Extracts); 0 (Plant Preparations); 0 (triphala); MOR84MUD8E (chlorhexidine gluconate); R4KO0DY52L (Chlorhexidine)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170802
[Lr] Data última revisão:
170802
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170317
[St] Status:MEDLINE
[do] DOI:10.4103/aam.aam_43_16


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[PMID]:28230521
[Au] Autor:Kaewkla O; Thamchaipenet A; Franco CM
[Ad] Endereço:2​Department of Medical Biotechnology, School of Medicine, Flinders University, Bedford Park, SA 5042, Australia 1​Department of Biology, Faculty of Science, Mahasarakham University, Maha Sarakham Province 44150, Thailand.
[Ti] Título:Micromonospora terminaliae sp. nov., an endophytic actinobacterium isolated from the surface-sterilized stem of the medicinal plant Terminalia mucronata.
[So] Source:Int J Syst Evol Microbiol;67(2):225-230, 2017 02.
[Is] ISSN:1466-5034
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:An endophytic actinobacterium, strain TMS7T, was isolated from the stem of a Thai medicinal plant collected from the grounds of the Phujong-Nayoa National park, Ubon Ratchathani province, Thailand. As a result of a polyphasic taxonomy study, this strain was identified as a member of the genus Micromonospora. This strain was a Gram-stain-positive, aerobic actinobacterium with well-developed substrate mycelium with hyphae forming a single microspore was non-motile. Stran TMS7T was identified according to its 16S rRNA gene sequence as a new member of the genus Micromonospora. The closest phylogenetic members sharing a similarity were Micromonospora chersina DSM 44151T at 99.4 % and Micromonospora rosaria DSM 803T, Micromonospora tulbaghiae TVU1T, Micromonospora inositola DSM 43819T and Micromonospora endolithica DSM 44398T all at 99.2 %. Chemotaxonomic data including cell wall components, major menaquinones and major fatty acids confirmed the affiliation of strain TMS7T to the genus Micromonospora. The results of the phylogenetic analysis, addition to physiological and biochemical studies in combination with DNA-DNA hybridization, allowed the genotypic and phenotypic differentiation of strain TMS7T and the most closely related species with validly published names. The name proposed for the novel species is Micromonospora terminaliae sp. nov. The type strain is TMS7T (=DSM 101760T=NRRL B-65345T).
[Mh] Termos MeSH primário: Micromonospora/classificação
Filogenia
Caules de Planta/microbiologia
Terminalia/microbiologia
[Mh] Termos MeSH secundário: Técnicas de Tipagem Bacteriana
Composição de Bases
DNA Bacteriano/genética
Ácidos Graxos/química
Micromonospora/genética
Micromonospora/isolamento & purificação
Hibridização de Ácido Nucleico
Plantas Medicinais/microbiologia
RNA Ribossômico 16S/genética
Análise de Sequência de DNA
Tailândia
Vitamina K 2/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA, Bacterial); 0 (Fatty Acids); 0 (RNA, Ribosomal, 16S); 11032-49-8 (Vitamin K 2)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170224
[St] Status:MEDLINE
[do] DOI:10.1099/ijsem.0.001600


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[PMID]:28213992
[Au] Autor:Lee DY; Kim HW; Yang H; Sung SH
[Ad] Endereço:College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, 151-742, Republic of Korea.
[Ti] Título:Hydrolyzable tannins from the fruits of Terminalia chebula Retz and their α-glucosidase inhibitory activities.
[So] Source:Phytochemistry;137:109-116, 2017 May.
[Is] ISSN:1873-3700
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Nine hydrolyzable tannins, including three previously unknown and six artifacts, were isolated, together with thirty-nine known ones, from the fruits of Terminalia chebula Retz. (Combretaceae). They were identified as 1,2,3-tri-O-galloyl-6-O-cinnamoyl-ß-d-glucose, 1,2,3,6-tetra-O-galloyl-4-O-cinnamoyl-ß-d-glucose, 4-O-(2″,4″-di-O-galloyl-α-l-rhamnosyl)ellagic acid, 1'-O-methyl neochebulanin, dimethyl neochebulinate, 6'-O-methyl neochebulagate, dimethyl neochebulagate, dimethyl 4'-epi-neochebulagate, and methyl chebulagate by the spectroscopic interpretation. After evaluation for α-glucosidase inhibition of all isolated compounds, 1,2,3,6-tetra-O-galloyl-4-O-cinnamoyl-ß-d-glucose and 4-O-(2″,4″-di-O-galloyl-α-l-rhamnosyl)ellagic acid showed significant inhibitory activities with IC values of 2.9 and 6.4 µM, respectively. In addition, inhibition kinetic studies showed that both compounds have mixed-type inhibitory activities with the inhibition constants (Ki) of 1.9 and 4.0 µM, respectively.
[Mh] Termos MeSH primário: Frutas/química
Inibidores de Glicosídeo Hidrolases/química
Taninos Hidrolisáveis/química
Terminalia/química
[Mh] Termos MeSH secundário: Inibidores de Glicosídeo Hidrolases/isolamento & purificação
Taninos Hidrolisáveis/isolamento & purificação
Estrutura Molecular
Extratos Vegetais/química
alfa-Glucosidases/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Glycoside Hydrolase Inhibitors); 0 (Hydrolyzable Tannins); 0 (Plant Extracts); EC 3.2.1.20 (alpha-Glucosidases)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170407
[Lr] Data última revisão:
170407
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170219
[St] Status:MEDLINE



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