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[PMID]:28845763
[Au] Autor:Ibrahim M; Rehman K; Hussain I; Farooq T; Ali B; Majeed I; Akash MSH
[Ad] Endereço:Department of Applied Chemistry, Government College University, Faisalabad, Pakistan.
[Ti] Título:Ethnopharmacological Investigations of Phytochemical Constituents Isolated from the Genus Cuscuta.
[So] Source:Crit Rev Eukaryot Gene Expr;27(2):113-150, 2017.
[Is] ISSN:1045-4403
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:The genus Cuscuta, of the family Cuscutaceae, is present in plants and has been traditionally used medicinally against many diseases and conditions, notably depression, mental illness, headache, spleen disease, jaundice, diabetes mellitus, and hypertension. Large numbers of phytochemical constituents such as alkaloids, flavonoids, lignins, oxygen heterocyclic compounds, steroids, fatty acids, phenolic acids, resin glycosides, and polysaccharides have been isolated from different species of Cuscuta. Ethnopharmacological studies conducted on such constituents have also been shown Cuscuta to possess anticancer, antiviral, antispasmodic, antihypertensive, anticonvulsant, antibacterial, antioxidant, diuretic, and hair-growth activity. Many tribes and traditional communities have long used the different forms of Cuscuta for treatment and prevention of many diseases. In this article, we comprehensively summarize relevant data regarding the phytochemical, ethnopharmacological, and traditional therapeutic uses of Cuscuta. In addition, we review the parts of the plants that are used as traditional therapeutic agents, their regions of existence, and their possible modes of action. To conclude, we provide evidence and new insights for further discovery and development of natural drugs from Cuscuta. We show that further studies are needed to investigate the mechanism of action and safety profile of phytochemical constituents isolated from Cuscuta.
[Mh] Termos MeSH primário: Cuscuta/química
Compostos Fitoquímicos/uso terapêutico
[Mh] Termos MeSH secundário: Etnofarmacologia
Compostos Fitoquímicos/química
Compostos Fitoquímicos/isolamento & purificação
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Phytochemicals)
[Em] Mês de entrada:1709
[Cu] Atualização por classe:170911
[Lr] Data última revisão:
170911
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170829
[St] Status:MEDLINE
[do] DOI:10.1615/CritRevEukaryotGeneExpr.2017019193


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[PMID]:28103731
[Au] Autor:Niazi SG; Uttra AM; Qaiser MN; Ahsan H
[Ad] Endereço:a Department of Pharmacology, Faculty of Pharmacy , University of Sargodha , Sargodha , Pakistan.
[Ti] Título:Appraisal of anti-arthritic and nephroprotective potential of Cuscuta reflexa.
[So] Source:Pharm Biol;55(1):792-798, 2017 Dec.
[Is] ISSN:1744-5116
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:CONTEXT: Cuscuta reflexa Roxb. (Cuscutaceae) has been used traditionally for treating sore knees and kidney problems, but its efficacy has not been scientifically examined in treating arthritis and nephrotoxicity. OBJECTIVE: Present study determines antiarthritic and nephroprotective potential of the aqueous methanolic extract of Cuscuta reflexa (AMECR). MATERIALS AND METHODS: Antiarthritic activity of Cuscuta reflexa in formaldehyde and turpentine oil-induced rat arthritis models was appraised at 200, 400 and 600 mg/kg doses for 10 days and 6 h period, respectively, and in vitro protein denaturation (bovine serum albumin, egg albumin) inhibition was studied at 25-800 µg/mL concentration. The nephroprotective effect involved gentamicin-induced nephrotoxicity in rats at 200, 400 and 600 mg/kg doses. RESULTS: Plant extract at 600 mg/kg significantly reduced paw oedema and joint swelling with maximal inhibition of 71.22% at the 6th hour for turpentine oil and 76.74% on 10th day for formaldehyde. Likewise, in vitro results corroborated significant concentration-dependent increase in percentage protection at 800 µg/mL against both bovine serum albumin (89.30%) and egg albumin (93.51%) denaturation. Similarly, 600 mg/kg dose showed maximum nephroprotection by reducing serum urea (41.400 ± 0.510 mg/dL), uric acid (0.740 ± 0.032 mg/dL), blood urea nitrogen (18.370 ± 0.328), creatinine (3.267 ± 0.076) and minimizing kidney weight gain (0.586 ± 0.005) and histopathological alterations on 8th day. Furthermore, phytochemical and HPLC analysis revealed the presence of important phytoconstituents. DISCUSSION AND CONCLUSIONS: These results suggest that AMECR provides protection against arthritis and nephrotoxicity that might be due to the existence of phytoconstituents, thus supporting folkloric claim.
[Mh] Termos MeSH primário: Antirreumáticos/uso terapêutico
Artrite Experimental/tratamento farmacológico
Cuscuta
Nefropatias/prevenção & controle
Componentes Aéreos da Planta
Extratos Vegetais/uso terapêutico
[Mh] Termos MeSH secundário: Animais
Antirreumáticos/isolamento & purificação
Artrite Experimental/patologia
Bovinos
Galinhas
Relação Dose-Resposta a Droga
Feminino
Nefropatias/patologia
Masculino
Extratos Vegetais/isolamento & purificação
Substâncias Protetoras/isolamento & purificação
Substâncias Protetoras/uso terapêutico
Ratos
Ratos Sprague-Dawley
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antirheumatic Agents); 0 (Plant Extracts); 0 (Protective Agents)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170302
[Lr] Data última revisão:
170302
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170121
[St] Status:MEDLINE
[do] DOI:10.1080/13880209.2017.1280513


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[PMID]:27450325
[Au] Autor:Riaz M; Bilal A; Ali MS; Fatima I; Faisal A; Sherkheli MA; Asghar A
[Ad] Endereço:a Department of Chemistry , University of AJK , Muzaffarabad , Pakistan.
[Ti] Título:Natural products from Cuscuta reflexa Roxb. with antiproliferation activities in HCT116 colorectal cell lines.
[So] Source:Nat Prod Res;31(5):583-587, 2017 Mar.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Parasitic Cuscuta reflexa Roxb. possesses many medicinal properties and is a rich source of a variety of biologically relevant natural products. Natural products are the prime source of leads, drugs, and drug templates, and many of the anticancer and antiviral drugs are either based on natural product or derived from them. Cancer is a devastating disease and one of the leading causes of death worldwide despite improvements in patient survival during the past 50 years; new and improved treatments for cancer are therefore actively sought. Colorectal cancer is the fourth most prevalent cancer worldwide and is responsible for nearly 9% of all cancer deaths. Our search for anticancer natural products from C. reflexa has yielded four natural products: Scoparone (1), p-coumaric acid (2), stigmasta-3,5-diene (3) and 1-O-p-hydroxycinnamoylglucose (4) and among them 1-O-p-hydroxycinnamoyldlucose (4) showed promising antiproliferative activities in HCT116 colorectal cell lines, whereas compounds 1-3 showed moderate activities.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/farmacologia
Produtos Biológicos/farmacologia
Cuscuta/química
[Mh] Termos MeSH secundário: Proliferação Celular/efeitos dos fármacos
Células HCT116
Seres Humanos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Biological Products)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170817
[Lr] Data última revisão:
170817
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160725
[St] Status:MEDLINE
[do] DOI:10.1080/14786419.2016.1198349


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[PMID]:26260045
[Au] Autor:Choopani R; Mehrbani M; Fekri A; Mehrabani M
[Ad] Endereço:Department of Traditional Medicine, School of Traditional Medicine, Traditional Medicine and Materia Medica Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
[Ti] Título:Treatment of Atopic Dermatitis From the Perspective of Traditional Persian Medicine: Presentation of a Novel Therapeutic Approach.
[So] Source:J Evid Based Complementary Altern Med;22(1):5-11, 2017 Jan.
[Is] ISSN:2156-5899
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:There is a strong current trend for using complementary and alternative medications to treat atopic dermatitis. Atopic dermatitis is a common, chronic, pruritic, and inflammatory skin disease. It can have a profound, negative effect on patients' quality of life. Mild cases of atopic dermatitis can be controlled by the application of moisturizers and topical corticosteroids. However, in severe cases, application of immunosuppressive medication is unavoidable but it can have adverse effects. In traditional Persian medicine, diseases similar to resistant atopic dermatitis are treated with whey in combination with decoction of field dodder. Both whey and field dodder have anti-inflammatory properties. Consumption of whey can also aid skin repair, mitigate pruritus, and help combat the high level of stress experienced by patients. Therefore, it is hypothesized that consumption of traditional medicinal treatment of whey with decoction of field dodder can be applied as a complementary treatment for atopic dermatitis.
[Mh] Termos MeSH primário: Dermatite Atópica
Medicina Arábica
[Mh] Termos MeSH secundário: Produtos Biológicos/uso terapêutico
Cuscuta/química
Dermatite Atópica/fisiopatologia
Dermatite Atópica/terapia
Seres Humanos
Irã (Geográfico)
Extratos Vegetais/uso terapêutico
Soro do Leite/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biological Products); 0 (Plant Extracts)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170627
[Lr] Data última revisão:
170627
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150812
[St] Status:MEDLINE


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[PMID]:27941627
[Au] Autor:Peng WH; Chen YW; Lee MS; Chang WT; Tsai JC; Lin YC; Lin MK
[Ad] Endereço:Department of Chinese Pharmaceutical Sciences and Chinese Medicine Resources, College of Biopharmaceutical and Food Sciences, China Medical University, 91 Hsueh-Shih Road, Taichung 40402, Taiwan. whpeng@mail.cmu.edu.tw.
[Ti] Título:Hepatoprotective Effect of Cuscuta campestris Yunck. Whole Plant on Carbon Tetrachloride Induced Chronic Liver Injury in Mice.
[So] Source:Int J Mol Sci;17(12), 2016 Dec 07.
[Is] ISSN:1422-0067
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Cuscuta seeds and whole plant have been used to nourish the liver and kidney. This study was aimed to investigate the hepatoprotective activity of the ethanol extract of Yunck. whole plant (CC ). The hepatoprotective effect of CC (20, 100 and 500 mg/kg) was evaluated on carbon tetrachloride (CCl4)-induced chronic liver injury. Serum alanine aminotransferase, aspartate aminotransferase, triglyceride and cholesterol were measured and the fibrosis was histologically examined. CC exhibited a significant inhibition of the increase of serum alanine aminotransferase, aspartate aminotransferase, triglyceride and cholesterol. Histological analyses showed that fibrosis of liver induced by CCl4 were significantly reduced by CC . In addition, 20, 100 and 500 mg/kg of the extract decreased the level of malondialdehyde (MDA) and enhanced the activities of anti-oxidative enzymes including superoxide dismutase (SOD), glutathione peroxidase (GPx) and glutathione reductase (GRd) in the liver. We demonstrate that the hepatoprotective mechanisms of CC were likely to be associated to the decrease in MDA level by increasing the activities of antioxidant enzymes such as SOD, GPx and GRd. In addition, our findings provide evidence that Yunck. whole plant possesses a hepatoprotective activity to ameliorate chronic liver injury.
[Mh] Termos MeSH primário: Antioxidantes/uso terapêutico
Cuscuta/química
Fígado/efeitos dos fármacos
Fígado/metabolismo
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Alanina Transaminase/sangue
Animais
Antioxidantes/química
Aspartato Aminotransferases/sangue
Intoxicação por Tetracloreto de Carbono
Catalase/metabolismo
Glutationa/metabolismo
Glutationa Peroxidase/metabolismo
Peroxidação de Lipídeos/efeitos dos fármacos
Fígado/lesões
Masculino
Malondialdeído/metabolismo
Camundongos
Estresse Oxidativo/efeitos dos fármacos
Extratos Vegetais/química
Sementes/química
Superóxido Dismutase/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Plant Extracts); 4Y8F71G49Q (Malondialdehyde); EC 1.11.1.6 (Catalase); EC 1.11.1.9 (Glutathione Peroxidase); EC 1.15.1.1 (Superoxide Dismutase); EC 2.6.1.1 (Aspartate Aminotransferases); EC 2.6.1.2 (Alanine Transaminase); GAN16C9B8O (Glutathione)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170501
[Lr] Data última revisão:
170501
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161213
[St] Status:MEDLINE


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[PMID]:27649679
[Au] Autor:Rath D; Kar DM; Panigrahi SK; Maharana L
[Ad] Endereço:Department of Pharmacology, School of Pharmaceutical Sciences, Siksha 'O' Anusandhan University, Bhubaneswar, Odisha, India.
[Ti] Título:Antidiabetic effects of Cuscuta reflexa Roxb. in streptozotocin induced diabetic rats.
[So] Source:J Ethnopharmacol;192:442-449, 2016 Nov 04.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:ETHNOPHARMACOLOGICAL RELEVANCE: Cuscuta reflexa Roxb. (Convolvulaceae) is traditionally used to treat diabetes mellitus by tribal people of north-east India and Bangladesh. OBJECTIVES: To evaluate the anti-diabetic effects of methanol and aqueous extracts of the aerial parts of Cuscuta reflexa Roxb. in normal, glucose loaded and Streptozotocin (STZ) induced diabetic rats. MATERIALS AND METHODS: The methanol (MECR) and aqueous (AECR) extracts (200 and 400mg/kg body weight) were administered orally to normal and diabetic rats with Metformin and solvent control as comparison groups. Long term effects like FBG, OGTT, lipid profile, HbA1c, body weight, histopathology of major organs, etc. were investigated. RESULTS: MECR and AECR did not have hypoglycemic effects in normal rats. Both AECR and MECR (400mg/kg) treatments showed significant reduction in blood glucose during OGTT in diabetic rats at 3h. Single oral administration of methanol and aqueous extracts (400mg/kg) to diabetic rats significantly reduced (p<0.05) blood glucose level to 61.90% and 55.39% respectively as compared to the Metformin group i.e. 68.32% at the end of 8h. MECR (400mg/kg body weight for 30 days to diabetic rats) showed a significant decrease (p<0.01) of blood glucose level to 60.00% as compared to other groups. The treatment also resulted an improvement in body weights, decreased HbA1c and restored lipid profile. Histopathological injury was not observed, rather repair of beta cells was seen in extract treated diabetic rats. CONCLUSION: Methanolic extract of C. reflexa has significant antidiabetic effects and improves metabolic alterations thereby justifying its traditional folkloric claims.
[Mh] Termos MeSH primário: Glicemia/efeitos dos fármacos
Cuscuta/química
Diabetes Mellitus Experimental/tratamento farmacológico
Hipoglicemiantes/farmacologia
Extratos Vegetais/farmacologia
Estreptozocina
[Mh] Termos MeSH secundário: Animais
Biomarcadores/sangue
Glicemia/metabolismo
Peso Corporal/efeitos dos fármacos
Cuscuta/toxicidade
Diabetes Mellitus Experimental/sangue
Diabetes Mellitus Experimental/induzido quimicamente
Relação Dose-Resposta a Droga
Hemoglobina A Glicada/metabolismo
Hipoglicemiantes/isolamento & purificação
Hipoglicemiantes/toxicidade
Lipídeos/sangue
Masculino
Metformina/farmacologia
Metanol/química
Fitoterapia
Componentes Aéreos da Planta/química
Extratos Vegetais/isolamento & purificação
Extratos Vegetais/toxicidade
Plantas Medicinais
Ratos
Solventes/química
Fatores de Tempo
Água/química
[Pt] Tipo de publicação:COMPARATIVE STUDY; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biomarkers); 0 (Blood Glucose); 0 (Glycated Hemoglobin A); 0 (Hypoglycemic Agents); 0 (Lipids); 0 (Plant Extracts); 0 (Solvents); 059QF0KO0R (Water); 5W494URQ81 (Streptozocin); 9100L32L2N (Metformin); Y4S76JWI15 (Methanol)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160922
[St] Status:MEDLINE


  7 / 164 MEDLINE  
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[PMID]:27529694
[Au] Autor:Tjiurutue MC; Palmer-Young EC; Adler LS
[Ad] Endereço:Biology Department, University of Massachusetts Amherst, 221 Morrill Science Center South, 611 North Pleasant Street, Amherst, MA, 01003, United States of America.
[Ti] Título:Parasite Removal, but Not Herbivory, Deters Future Parasite Attachment on Tomato.
[So] Source:PLoS One;11(8):e0161076, 2016.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Plants face many antagonistic interactions that occur sequentially. Often, plants employ defense strategies in response to the initial damage that are highly specific and can affect interactions with subsequent antagonists. In addition to herbivores and pathogens, plants face attacks by parasitic plants, but we know little about how prior herbivory compared to prior parasite attachment affects subsequent host interactions. If host plants can respond adaptively to these different damage types, we predict that prior parasitism would have a greater deterrent effect on subsequent parasites than would prior herbivory. To test the effects of prior parasitism and prior herbivory on subsequent parasitic dodder (Cuscuta spp.) preference, we conducted two separate greenhouse studies with tomato hosts (Solanum lycopersicum). In the first experiment, we tested the effects of previous dodder attachment on subsequent dodder preference on tomato hosts using three treatments: control plants that had no previous dodder attachment; dodder-removed plants that had an initial dodder seedling attached, removed and left in the same pot to simulate parasite death; and dodder-continuous plants with an initial dodder seedling that remained attached. In the second experiment, we tested the effects of previous caterpillar damage (Spodoptera exigua) and mechanical damage on future dodder attachment on tomato hosts. Dodder attached most slowly to tomato hosts that had dodder plants previously attached and then removed, compared to control plants or plants with continuous dodder attachment. In contrast, herbivory did not affect subsequent dodder attachment rate. These results indicate that dodder preference depended on the identity and the outcome of the initial attack, suggesting that early-season interactions have the potential for profound impacts on subsequent community dynamics.
[Mh] Termos MeSH primário: Interações Hospedeiro-Parasita
Lycopersicon esculentum/parasitologia
[Mh] Termos MeSH secundário: Animais
Cuscuta/parasitologia
Herbivoria
Estações do Ano
Spodoptera/fisiologia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170802
[Lr] Data última revisão:
170802
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160817
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0161076


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[PMID]:27482077
[Au] Autor:Smith JD; Woldemariam MG; Mescher MC; Jander G; De Moraes CM
[Ad] Endereço:Department of Biology, Dickinson College, Carlisle, Pennsylvania 17013 (J.D.S.);Boyce Thompson Institute for Plant Research, Ithaca, New York 14853 (M.G.W., G.J.); andDepartment of Environmental Systems Science, Swiss Federal Institute of Technology, CH-8092 Zurich, Switzerland (M.C.M., C.M.D.M.).
[Ti] Título:Glucosinolates from Host Plants Influence Growth of the Parasitic Plant Cuscuta gronovii and Its Susceptibility to Aphid Feeding.
[So] Source:Plant Physiol;172(1):181-97, 2016 Sep.
[Is] ISSN:1532-2548
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Parasitic plants acquire diverse secondary metabolites from their hosts, including defense compounds that target insect herbivores. However, the ecological implications of this phenomenon, including the potential enhancement of parasite defenses, remain largely unexplored. We studied the translocation of glucosinolates from the brassicaceous host plant Arabidopsis (Arabidopsis thaliana) into parasitic dodder vines (Convolvulaceae; Cuscuta gronovii) and its effects on the parasite itself and on dodder-aphid interactions. Aliphatic and indole glucosinolates reached concentrations in parasite tissues higher than those observed in corresponding host tissues. Dodder growth was enhanced on cyp79B2 cyp79B3 hosts (without indole glucosinolates) but inhibited on atr1D hosts (with elevated indole glucosinolates) relative to wild-type hosts, which responded to parasitism with localized elevation of indole and aliphatic glucosinolates. These findings implicate indole glucosinolates in defense against parasitic plants. Rates of settling and survival on dodder vines by pea aphids (Acyrthosiphon pisum) were reduced significantly when dodder parasitized glucosinolate-producing hosts (wild type and atr1D) compared with glucosinolate-free hosts (cyp79B2 cyp79B3 myb28 myb29). However, settling and survival of green peach aphids (Myzus persicae) were not affected. M. persicae population growth was actually reduced on dodder parasitizing glucosinolate-free hosts compared with wild-type or atr1D hosts, even though stems of the former contain less glucosinolates and more amino acids. Strikingly, this effect was reversed when the aphids fed directly upon Arabidopsis, which indicates an interactive effect of parasite and host genotype on M. persicae that stems from host effects on dodder. Thus, our findings indicate that glucosinolates may have both direct and indirect effects on dodder-feeding herbivores.
[Mh] Termos MeSH primário: Afídeos/fisiologia
Arabidopsis/metabolismo
Cuscuta/fisiologia
Glucosinolatos/metabolismo
[Mh] Termos MeSH secundário: Animais
Afídeos/metabolismo
Arabidopsis/genética
Arabidopsis/parasitologia
Cromatografia Líquida de Alta Pressão
Cuscuta/metabolismo
Cuscuta/parasitologia
Comportamento Alimentar/fisiologia
Genótipo
Interações Hospedeiro-Parasita
Indóis/metabolismo
Mutação
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Glucosinolates); 0 (Indoles)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171006
[Lr] Data última revisão:
171006
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160803
[St] Status:MEDLINE
[do] DOI:10.1104/pp.16.00613


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[PMID]:27471302
[Au] Autor:Hegenauer V; Fürst U; Kaiser B; Smoker M; Zipfel C; Felix G; Stahl M; Albert M
[Ad] Endereço:Center for Plant Molecular Biology, University of Tübingen, 72076 Tübingen, Germany.
[Ti] Título:Detection of the plant parasite Cuscuta reflexa by a tomato cell surface receptor.
[So] Source:Science;353(6298):478-81, 2016 Jul 29.
[Is] ISSN:1095-9203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Parasitic plants are a constraint on agriculture worldwide. Cuscuta reflexa is a stem holoparasite that infests most dicotyledonous plants. One exception is tomato, which is resistant to C. reflexa We discovered that tomato responds to a small peptide factor occurring in Cuscuta spp. with immune responses typically activated after perception of microbe-associated molecular patterns. We identified the cell surface receptor-like protein CUSCUTA RECEPTOR 1 (CuRe1) as essential for the perception of this parasite-associated molecular pattern. CuRe1 is sufficient to confer responsiveness to the Cuscuta factor and increased resistance to parasitic C. reflexa when heterologously expressed in otherwise susceptible host plants. Our findings reveal that plants recognize parasitic plants in a manner similar to perception of microbial pathogens.
[Mh] Termos MeSH primário: Cuscuta/metabolismo
Etilenos/biossíntese
Lycopersicon esculentum/imunologia
Proteínas de Plantas/metabolismo
Receptores de Reconhecimento de Padrão/imunologia
[Mh] Termos MeSH secundário: Cuscuta/genética
Lycopersicon esculentum/genética
Lycopersicon esculentum/metabolismo
Peptídeos/química
Extratos Vegetais/química
Proteínas de Plantas/genética
Receptores de Reconhecimento de Padrão/genética
Receptores de Reconhecimento de Padrão/metabolismo
Transdução de Sinais
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Ethylenes); 0 (Peptides); 0 (Plant Extracts); 0 (Plant Proteins); 0 (Receptors, Pattern Recognition); 91GW059KN7 (ethylene)
[Em] Mês de entrada:1610
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160730
[St] Status:MEDLINE
[do] DOI:10.1126/science.aaf3919


  10 / 164 MEDLINE  
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[PMID]:27440175
[Au] Autor:Furuhashi T; Nakamura T; Fragner L; Roustan V; Schön V; Weckwerth W
[Ad] Endereço:Department of Ecogenomics and Systems Biology, Vienna University, Vienna, Austria. takeshi.furuhashi@univie.ac.at.
[Ti] Título:Biodiesel and poly-unsaturated fatty acids production from algae and crop plants - a rapid and comprehensive workflow for lipid analysis.
[So] Source:Biotechnol J;11(10):1262-1267, 2016 Oct.
[Is] ISSN:1860-7314
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Fatty acid methyl ester analysis (FAME) by gas chromatography coupled to mass spectrometry (GC-MS) is a widely used technique in biodiesel/bioproduct (e.g. poly-unsaturated fatty acids, PUFA) research but typically does not allow distinguishing between bound and free fatty acids. To understand and optimize biosynthetic pathways, however, the origin of the fatty acid is an important information. Furthermore the annotation of PUFAs is compromised in classical GC-EI-MS because the precursor molecular ion is missing. In the present protocol an alkaline methyl esterification step with TMS derivatization enabling the simultaneous analysis of bound and free fatty acids but also further lipids such as sterols in one GC-MS chromatogram is combined. This protocol is applied to different lipid extracts from single cell algae to higher plants: Chlorella vulgaris, Chlamydomonas reinhardtii, Coffea arabica, Pisum sativum and Cuscuta japonica. Further, field ionization (GC-FI-MS) is introduced for a better annotation of fatty acids and exact determination of the number of double bonds in PUFAs. The proposed workflow provides a convenient strategy to analyze algae and other plant crop systems with respect to their capacity for third generation biodiesel and high-quality bioproducts for nutrition such as PUFAs.
[Mh] Termos MeSH primário: Biocombustíveis/análise
Clorófitas/metabolismo
Ácidos Graxos Insaturados/análise
Cromatografia Gasosa-Espectrometria de Massas/métodos
Magnoliopsida/metabolismo
[Mh] Termos MeSH secundário: Vias Biossintéticas
Chlamydomonas reinhardtii/metabolismo
Chlorella vulgaris/metabolismo
Coffea/metabolismo
Cuscuta/metabolismo
Ácidos Graxos Insaturados/metabolismo
Ervilhas/metabolismo
Análise de Célula Única
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Biofuels); 0 (Fatty Acids, Unsaturated)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:171116
[Lr] Data última revisão:
171116
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160722
[St] Status:MEDLINE
[do] DOI:10.1002/biot.201400197



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