Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.300.093 [Categoria DeCS]
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  1 / 19 MEDLINE  
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[PMID]:27430383
[Au] Autor:Dhouioui M; Boulila A; Jemli M; Schiets F; Casabianca H; Zina MS
[Ad] Endereço:Institut National de Recherche et d'Analyse Physico-chimique (INRAP), Laboratoire des Substances Naturelles, Biotechpôle de Sidi Thabet.
[Ti] Título:Fatty Acids Composition and Antibacterial Activity of Aristolochia longa L. and Bryonia dioïca Jacq. Growing Wild in Tunisia.
[So] Source:J Oleo Sci;65(8):655-61, 2016 Aug 01.
[Is] ISSN:1347-3352
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:The composition of the fatty acids of the roots and aerial parts of Aritolochia longa (Aristolacheae) and Bryonia dioïca (Cucurbutaceae) was analyzed by gas chromatography (GC-FID) and gas chromatography-mass spectrometry (GC-MS). The oils extracted from the aerial parts of both species were rich in polyunsaturated fatty acids with the essential linolenic and linoleic acids being the most prominent compounds. Oleic and linoleic acids were the majors fatty acids in the roots of both species. Whatever the plant part analyzed and the species, the saturated fatty acids were predominantly composed of palmitic and stearic acids. The antibacterial activity, minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of the lipid extracts were determined against a panel of five bacterial strains. The results showed that the sensitivity to the lipid extracts was different for the test bacterial strains, and the susceptibility of gram positive bacteria was found to be greater than gram negative bacteria. The antibacterial activity of the root lipid extracts was particularly important against Enterococcus feacium (CMI value of 125 µg/mL; CMB values > 250 µg/mL) and Streptococcus agalactiae (CMI value of 125 µg/mL; CMB values 250 µg/mL for A. longa roots). These results indicate that A. longa and B. dioïca could be considered as good sources of essential fatty acids which can act as natural antibacterial agents.
[Mh] Termos MeSH primário: Antibacterianos/química
Antibacterianos/farmacologia
Aristolochia/química
Aristolochia/crescimento & desenvolvimento
Bryonia/química
Bryonia/crescimento & desenvolvimento
Ácidos Graxos/análise
[Mh] Termos MeSH secundário: Antibacterianos/isolamento & purificação
Relação Dose-Resposta a Droga
Ácidos Graxos/química
Ácidos Graxos/isolamento & purificação
Ácidos Graxos/farmacologia
Bactérias Gram-Negativas/efeitos dos fármacos
Bactérias Gram-Positivas/efeitos dos fármacos
Testes de Sensibilidade Microbiana
Componentes Aéreos da Planta/química
Raízes de Plantas/química
Relação Estrutura-Atividade
Tunísia
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Fatty Acids)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170302
[Lr] Data última revisão:
170302
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160720
[St] Status:MEDLINE
[do] DOI:10.5650/jos.ess16001


  2 / 19 MEDLINE  
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[PMID]:25797117
[Au] Autor:Yamani A; Bunel V; Antoine MH; Husson C; Stévigny C; Duez P; Elachouri M; Nortier J
[Ad] Endereço:Laboratory of Experimental Nephrology, Faculty of Medicine, Université Libre de Bruxelles (ULB), Brussels, Belgium; Laboratory of Pharmacognosy, Bromatology and Human Nutrition, Faculty of Pharmacy, Université Libre de Bruxelles (ULB), Brussels, Belgium; Laboratory of Physiology and Ethnopharmacolog
[Ti] Título:Substitution between Aristolochia and Bryonia genus in North-Eastern Morocco: toxicological implications.
[So] Source:J Ethnopharmacol;166:250-60, 2015 May 26.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:ETHNOPHARMACOLOGICAL RELEVANCE: Although acknowledged as toxic herbs, Aristolochia species are still widely used worldwide. The aristolochic acids (AA) they contain can induce the so-called "aristolochic acid nephropathy", leading to renal fibrosis and upper urinary tract cancer. Traditional Moroccan medicine still often uses Aristolochia species under the vernacular name of Bereztem for the treatment of numerous ailments, notably cancer, diabetes or digestive tract disorders. As the botanical identity and renal toxicity of used species remain unexplored, the safety of patients may be threatened. MATERIAL AND METHODS: Ethnopharmacological data were collected from herbalists from the provinces of Oujda and Berkane, located in North-Eastern Morocco. Samples of Bereztem were collected at herbalist shops and checked for their content in AA using TLC and LC-MS methods. The toxicity of crude methanolic extracts of each herb was assessed on a HK-2 cell-based in vitro model by measurement of the cell survival to evaluate cytotoxicity and by assessment of renal-specific toxicity via (i) the evaluation of genes (E-cadherin and α-smooth muscle actin) expression by RT-qPCR; (ii) the quantities of ß-catenin and vimentin by immunofluorescence microscopy; (iii) the secretion of fibronectin; and (iv) the excretion of interleukin-6. RESULTS: The survey indicated that, among 42 herbalists visited, 33 were retailers of Bereztem, which was generally sold as a cancer treatment. Botanical investigations revealed that Aristolochia longa was frequently substituted by Bryonia dioica, which was associated with a higher cytotoxicity. Parameters specific to renal toxicity were also found to be enhanced, as compared to Aristolochia baetica and A. longa: down-regulation of ß-catenin and E-cadherin and up-regulation of vimentin and α-smooth muscle actin, and secretion of fibronectin and interleukin-6. CONCLUSION: In accordance with the Moroccan regulations, the use of so-called Aristolochia species should be discontinued. On one hand, the correctly identified aristolochia contain nephrotoxic aristolochic acids; on the other hand, aristolochia are massively substituted in North-Eastern Morocco and adulterated by a well-known toxic herb, B. dioica. Our data indicate that the bryony renal toxicity may be deleterious in shorter time periods than aristolochia. Reinforced on-site controls are needed to remind herbalists and harvesters that these herbs should be prohibited.
[Mh] Termos MeSH primário: Aristolochia/efeitos adversos
Bryonia/efeitos adversos
Nefropatias/induzido quimicamente
Rim/efeitos dos fármacos
Extratos Vegetais/efeitos adversos
Plantas Medicinais/efeitos adversos
[Mh] Termos MeSH secundário: Actinas/metabolismo
Aristolochia/química
Bryonia/química
Caderinas/metabolismo
Linhagem Celular
Sobrevivência Celular/efeitos dos fármacos
Regulação para Baixo/efeitos dos fármacos
Etnofarmacologia/métodos
Fibronectinas/metabolismo
Seres Humanos
Interleucina-6/metabolismo
Rim/metabolismo
Nefropatias/metabolismo
Marrocos
Extratos Vegetais/química
Plantas Medicinais/química
Regulação para Cima/efeitos dos fármacos
beta Catenina/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (ACTA2 protein, human); 0 (Actins); 0 (Cadherins); 0 (Fibronectins); 0 (IL6 protein, human); 0 (Interleukin-6); 0 (Plant Extracts); 0 (beta Catenin)
[Em] Mês de entrada:1601
[Cu] Atualização por classe:150420
[Lr] Data última revisão:
150420
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150324
[St] Status:MEDLINE


  3 / 19 MEDLINE  
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[PMID]:25284295
[Au] Autor:Dhapte V; Kadam S; Moghe A; Pokharkar V
[Ad] Endereço:Department of Pharmaceutics, Bharati Vidyapeeth University, Poona College of Pharmacy, Pune, India.
[Ti] Título:Probing the wound healing potential of biogenic silver nanoparticles.
[So] Source:J Wound Care;23(9):431-2, 434, 436 passim, 2014 Sep.
[Is] ISSN:0969-0700
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:OBJECTIVE: Silver nanoparticles (AgNPs) are known for their antimicrobial profile and wound healing activities. However, cytotoxicity and cosmetic abnormalities associated with silver pose a major challenge in their translation for therapeutic applications. Our objective was to develop biogenic AgNPs, using a single-step green synthesis, and to investigate their in vitro and in vivo behaviour as wound-healing agents. METHOD: AgNPs were prepared using the green synthesis approach with aqueous Bryonia laciniosa leaves extract. The AgNPs were then evaluated for physicochemical properties, stability, and antimicrobial and in vivo wound healing activities. RESULTS: Stable AgNPs with characteristic absorption at 408nm and 15±3nm particle size were generated via the active involvement of Bryonia laciniosa. No loss of stability was detected after 6 months at room temperature. Antibacterial activity was observed against both Gram-negative and Gram-positive bacteria with no cytotoxicity observed in vitro at a concentration of 200 µg/mL and effective cytokine modulation. In vivo wound healing experiments showed improved wound contracting ability in rats where, after 14 days, wound alleviation was 47.1±2.2% in the control groups, compared with 78.1±1.4% and 92.6±6.7% for a silver-based marketed cream and the AgNPs, respectively. CONCLUSION: The developed AgNPs proved to be superior wound healing agents owing to scarless healing with insignificant inflammation and toxicity. DECLARATION OF INTEREST: There were no external sources of funding for this study. The authors have no conflicts of interest to declare.
[Mh] Termos MeSH primário: Nanopartículas Metálicas/uso terapêutico
Prata/administração & dosagem
Cicatrização
[Mh] Termos MeSH secundário: Animais
Bryonia
Ensaio de Imunoadsorção Enzimática
Nanopartículas Metálicas/química
Extratos Vegetais
Ratos
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Extracts); 3M4G523W1G (Silver)
[Em] Mês de entrada:1501
[Cu] Atualização por classe:141006
[Lr] Data última revisão:
141006
[Sb] Subgrupo de revista:N
[Da] Data de entrada para processamento:141007
[St] Status:MEDLINE
[do] DOI:10.12968/jowc.2014.23.9.431


  4 / 19 MEDLINE  
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[PMID]:23152306
[Au] Autor:García-Herrera P; Sánchez-Mata MC; Cámara M; Tardío J; Olmedilla-Alonso B
[Ad] Endereço:Departamento de Nutrición y Bromatología II, Facultad de Farmacia, Universidad Complutense de Madrid, Plaza de Ramón y Cajal s/n, 28040-Madrid, Spain.
[Ti] Título:Carotenoid content of wild edible young shoots traditionally consumed in Spain (Asparagus acutifolius L., Humulus lupulus L., Bryonia dioica Jacq. and Tamus communis L.).
[So] Source:J Sci Food Agric;93(7):1692-8, 2013 May.
[Is] ISSN:1097-0010
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Wild vegetables have traditionally been consumed as part of the Mediterranean diet, being valuable sources of nutrients and bioactive compounds. The objective of this work was to analyse the carotenoid content of the edible young shoots of four species (Asparagus acutifolius L., Humulus lupulus L., Bryonia dioica Jacq. and Tamus communis L.) as part of a wider study on the characterisation of the nutritional composition of wild edible plants commonly consumed in Spain. Samples were gathered from two locations in Central Spain for two consecutive years. RESULTS: Lutein, ß-carotene, neoxanthin and violaxanthin were quantified by high-performance liquid chromatography with a photodiode array detector. Median concentration ranges (µg g(-1) edible wet weight) were: ß-carotene, 3.39-6.69, lutein, 5.44­19.13;neoxanthin, 5.17-17.37; and violaxanthin, 2.08-8.93. The highest carotenoid content was that of B. dioica (59.01 µg g(-1)) and the lowest was found in A. acutifolius (17.58 µg g(-1)) [corrected]. CONCLUSION: Our results show that these wild young shoots are richer sources of carotenoids than many of the commercially available leafy vegetables.
[Mh] Termos MeSH primário: Asparagus (Planta)/química
Bryonia/química
Dieta
Humulus/química
Tamus/química
Xantofilas/análise
beta Caroteno/análise
[Mh] Termos MeSH secundário: Cromatografia Líquida de Alta Pressão
Seres Humanos
Luteína/análise
Brotos de Planta/química
Espanha
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Xanthophylls); 01YAE03M7J (beta Carotene); 51C926029A (violaxanthin); KK8M5T48AI (neoxanthin); X72A60C9MT (Lutein)
[Em] Mês de entrada:1310
[Cu] Atualização por classe:151119
[Lr] Data última revisão:
151119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:121116
[St] Status:MEDLINE
[do] DOI:10.1002/jsfa.5952


  5 / 19 MEDLINE  
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[PMID]:22465729
[Au] Autor:Benarba B; Meddah B; Aoues A
[Ad] Endereço:Laboratory Research on Biological Systems and Geomatics, Faculty of Nature and Life, University of Mascara, Algeria. bachirsb@yahoo.fr
[Ti] Título:Bryonia dioica aqueous extract induces apoptosis through mitochondrial intrinsic pathway in BL41 Burkitt's lymphoma cells.
[So] Source:J Ethnopharmacol;141(1):510-6, 2012 May 07.
[Is] ISSN:1872-7573
[Cp] País de publicação:Ireland
[La] Idioma:eng
[Ab] Resumo:ETHNOPHARMACOLOGICAL RELEVANCE: Bryonia dioica Jacq. is a climbing perennial herb with tuberous roots which is widely used in traditional medicine in Algeria for the treatment of cancers; it belongs to the genus Bryonia (Cucurbitaceae). AIM OF THE STUDY: To investigate the cytotoxic and apoptogenic activities, the phytochemical composition and acute toxicity of the aqueous extract of Bryonia dioica roots growing in Algeria. MATERIALS AND METHODS: Dried roots of Bryonia dioica were extracted with water (decoction). The cytotoxic effects of the aqueous extract in the Burkitt's lymphoma BL41 cell lines were evaluated by flow cytometry. Apoptosis induction was assessed by two corroborative assays; propidium iodide (PI) staining of cell DNA and flow cytometric light scatter analysis. The mitochondria membrane potential was investigated using a fluorescent dye DIOC6. The expression of caspases-3, -8, -9 and PARP was assessed by Western blot. The phytochemical screening of the roots of Bryonia dioica was performed using qualitative phytochemical standard procedures. RESULTS: The Bryonia dioica aqueous extract induced cell death in a dose-dependent manner. The IC50 of Bryonia dioica aqueous extract was estimated to be approximately 15, 63µg/ml. This was accompanied by induction of apoptosis, activation of caspase-3 and -9, cleavage of PARP and loss of mitochondria membrane potential. Furthermore, the phytochemical screening of roots of Bryonia dioica showed the presence of various bioactive such as polyphenols, sterols and triterpenes, alkaloids, c-heterosides, carbohydrates and saponins. CONCLUSION: The aqueous extract of Bryonia dioica induces apoptosis in the Burkitt's lymphoma BL41 cell lines via the mitochondrial pathway. The flavonoids, sterols and triterpens detected could be responsible for the cytotoxic and apoptogenic activities of the aqueous extract of Bryonia dioica. These findings suggest that Bryonia dioica could be considered as a promising source for developing novel therapeutics against Burkitt's lymphoma.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/farmacologia
Apoptose/efeitos dos fármacos
Bryonia
Linfoma de Burkitt/patologia
Mitocôndrias/efeitos dos fármacos
Extratos Vegetais/farmacologia
Transdução de Sinais/efeitos dos fármacos
[Mh] Termos MeSH secundário: Antineoplásicos Fitogênicos/química
Antineoplásicos Fitogênicos/isolamento & purificação
Antineoplásicos Fitogênicos/toxicidade
Western Blotting
Bryonia/química
Linfoma de Burkitt/metabolismo
Caspase 3/metabolismo
Caspase 9/metabolismo
Linhagem Celular Tumoral
Relação Dose-Resposta a Droga
Citometria de Fluxo
Seres Humanos
Concentração Inibidora 50
Luz
Potencial da Membrana Mitocondrial/efeitos dos fármacos
Mitocôndrias/metabolismo
Mitocôndrias/patologia
Fitoterapia
Extratos Vegetais/química
Extratos Vegetais/isolamento & purificação
Extratos Vegetais/toxicidade
Raízes de Plantas
Plantas Medicinais
Poli(ADP-Ribose) Polimerases/metabolismo
Espalhamento de Radiação
Solventes/química
Água/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Plant Extracts); 0 (Solvents); 059QF0KO0R (Water); EC 2.4.2.30 (Poly(ADP-ribose) Polymerases); EC 3.4.22.- (CASP3 protein, human); EC 3.4.22.- (CASP9 protein, human); EC 3.4.22.- (Caspase 3); EC 3.4.22.- (Caspase 9)
[Em] Mês de entrada:1208
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:120403
[St] Status:MEDLINE
[do] DOI:10.1016/j.jep.2012.02.052


  6 / 19 MEDLINE  
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[PMID]:20460809
[Au] Autor:Matsuda H; Nakashima S; Abdel-Halim OB; Morikawa T; Yoshikawa M
[Ad] Endereço:Kyoto Pharmaceutical University, Misasagi, Yamashina-ku, Kyoto 607-8412, Japan.
[Ti] Título:Cucurbitane-type triterpenes with anti-proliferative effects on U937 cells from an egyptian natural medicine, Bryonia cretica: structures of new triterpene glycosides, bryoniaosides A and B.
[So] Source:Chem Pharm Bull (Tokyo);58(5):747-51, 2010 May.
[Is] ISSN:1347-5223
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:The 90% aqueous ethanol extract of an Egyptian natural medicine, the roots of Bryonia cretica L., was found to exhibit a strong inhibitory effect on the proliferation of human leukemia U937 cells. By bioassay-guided fractionation, we isolated two new cucurbitane-type triterpene glycosides, bryoniaosides A and B, were isolated from the roots of Bryonia cretica L. together with 16 known cucurbitane-type triterpenes and glycosides. The chemical structures of bryoniaosides A and B were determined on the basis of chemical and spectroscopic evidence. Effects of principal cucurbitane-type triterpenes (cucurbitacins B, D, E, and J, 23,24-dihydrocucurbitacins B and E, and hexanorcucurbitacin D) on proliferation of the cells were examined. Cucurbitacins B and E showed the greater cytotoxic effects with IC(50) values of 9.2 and 16 nM after 72 h, and their IC(50) values were equivalent to that of camptothecin. An alpha,beta-conjugated ketone moiety at the 22-24-positions and an acetoxy group at the 25-position are essential for the strong activity.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/farmacologia
Bryonia/química
Glicosídeos/química
Extratos Vegetais/química
Raízes de Plantas/química
Triterpenos/química
[Mh] Termos MeSH secundário: Proliferação Celular/efeitos dos fármacos
Egito
Glicosídeos/isolamento & purificação
Glicosídeos/farmacologia
Seres Humanos
Concentração Inibidora 50
Leucemia/tratamento farmacológico
Espectroscopia de Ressonância Magnética
Estrutura Molecular
Extratos Vegetais/farmacologia
Triterpenos/isolamento & purificação
Triterpenos/farmacologia
Células U937
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Glycosides); 0 (Plant Extracts); 0 (Triterpenes); 0 (bryoniaoside A); 0 (bryoniaoside B); 0 (cucurbitane)
[Em] Mês de entrada:1009
[Cu] Atualização por classe:110308
[Lr] Data última revisão:
110308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:100513
[St] Status:MEDLINE


  7 / 19 MEDLINE  
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[PMID]:20233176
[Au] Autor:Cornu C; Joseph P; Gaillard S; Bauer C; Vedrinne C; Bissery A; Melot G; Bossard N; Belon P; Lehot JJ
[Ad] Endereço:INSERM, CIC 201, Lyon, Hospices Civils de Lyon, Service de Pharmacologie Clinique, Lyon, Université de Lyon, Lyon and CNRS, UMR 5558, Lyon, France. catherine.cornu@chu-lyon.fr
[Ti] Título:No effect of a homoeopathic combination of Arnica montana and Bryonia alba on bleeding, inflammation, and ischaemia after aortic valve surgery.
[So] Source:Br J Clin Pharmacol;69(2):136-42, 2010 Feb.
[Is] ISSN:1365-2125
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:AIMS: " Arnica montana is a popular homoeopathic treatment with potential haemostatic and anti-inflammatory properties. A homoeopathic combination of A. montana and Bryonia alba was used in aortic valve surgery to evaluate its effectiveness in reducing bleeding, inflammation, pain and myocardial ischaemia. METHODS: One day before surgery, 92 adult patients were randomly assigned to a double-blind parallel trial with either homoeopathic granules or a matching placebo until 4 days after surgery. The primary outcome was the volume of blood/liquid in the drains at their removal. The secondary outcomes included postoperative blood/liquid losses at 12 and 24 h as well as C-reactive protein (CRP), pain, temperature and plasma troponin Ic. RESULTS: At 12 h and 24 h after surgery, then at drain removal, blood losses in homoeopathy and placebo groups were not statistically significant (362 +/- 218, 520 +/- 269 and 640 +/- 297 ml vs. 456 +/- 440, 620 +/- 477 and 796 +/- 717 ml; P= 0.19, 0.23 and 0.35, respectively). The statistical modelling did not show significantly different patterns of CRP, troponin and body temperature changes or of pain perception. The number of transfused packed red cells was not significantly different either (P= 0.58). Two patients from each group died during the study period and the number of serious adverse events was not statistically different (six in homoeopathy vs. 10 in placebo groups; Fisher's exact test P= 0.41). CONCLUSIONS: In the study setting, there was no evidence of effects of A. montana and B. alba combination on bleeding, inflammation, pain or myocardial ischaemia.
[Mh] Termos MeSH primário: Arnica
Bryonia
Hemorragia/tratamento farmacológico
Homeopatia/métodos
Inflamação/tratamento farmacológico
Isquemia Miocárdica/tratamento farmacológico
Extratos Vegetais/uso terapêutico
Complicações Pós-Operatórias/tratamento farmacológico
[Mh] Termos MeSH secundário: Idoso
Idoso de 80 Anos ou mais
Valva Aórtica/cirurgia
Procedimentos Cirúrgicos Cardíacos/métodos
Método Duplo-Cego
Feminino
Seres Humanos
Masculino
Meia-Idade
Dor Pós-Operatória/tratamento farmacológico
Fitoterapia
Hemorragia Pós-Operatória/tratamento farmacológico
Análise de Regressão
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Plant Extracts)
[Em] Mês de entrada:1010
[Cu] Atualização por classe:141204
[Lr] Data última revisão:
141204
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:100318
[St] Status:MEDLINE
[do] DOI:10.1111/j.1365-2125.2009.03574.x


  8 / 19 MEDLINE  
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[PMID]:20108178
[Au] Autor:Sahranavard S; Naghibi F; Siems K; Jenett-Siems K
[Ad] Endereço:Pharmacognosy Department, School of Pharmacy, Shaheed Beheshti University of Medical Sciences, Tehran, Iran. ssahranavard@itmrc.org
[Ti] Título:New cucurbitane-type triterpenoids from Bryonia aspera.
[So] Source:Planta Med;76(10):1014-7, 2010 Jul.
[Is] ISSN:1439-0221
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:Phytochemical investigation of the chloroform extract of BRYONIA ASPERA roots resulted in the isolation and structure elucidation of two new cucurbitacins (1, 2) together with eight known cucurbitane derivatives (6-13), the pentacyclic triterpene bryonolic acid (5) and two hydroxybenzoic acid amides (3, 4). Their structures were elucidated by spectroscopic analysis, including 2D NMR techniques.
[Mh] Termos MeSH primário: Bryonia/química
Extratos Vegetais/química
Triterpenos/isolamento & purificação
[Mh] Termos MeSH secundário: Ácido Benzoico/isolamento & purificação
Glicosídeos/isolamento & purificação
Estrutura Molecular
Raízes de Plantas
Triterpenos/química
[Pt] Tipo de publicação:LETTER
[Nm] Nome de substância:
0 (Glycosides); 0 (Plant Extracts); 0 (Triterpenes); 0 (cucurbitacin C); 0 (cucurbitane); 5I62H4ORC7 (cucurbitacin D); 8SKN0B0MIM (Benzoic Acid); J7YR6A878I (bryonolic acid)
[Em] Mês de entrada:1102
[Cu] Atualização por classe:161125
[Lr] Data última revisão:
161125
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:100129
[St] Status:MEDLINE
[do] DOI:10.1055/s-0029-1240840


  9 / 19 MEDLINE  
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[PMID]:20032987
[Au] Autor:Chauhan NS; Dixit VK
[Ad] Endereço:Department of Pharmaceutical Sciences, Dr H S Gour University, Sagar, MP, India.
[Ti] Título:Effects of Bryonia laciniosa seeds on sexual behaviour of male rats.
[So] Source:Int J Impot Res;22(3):190-5, 2010 May-Jun.
[Is] ISSN:1476-5489
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Ethanolic extract of seeds of Bryonia laciniosa Linn was administered orally to groups of male albino rats at the dose levels of 50, 100, and 150 mg kg(-1) body weight per day for 28 days. The changes in sexual behaviour, reproductive organ weights, histology of testis and epididymis, epididymal sperm density, and androgenic hormone levels were evaluated. The sexual behaviour parameters studied such as mount frequency, intromission frequency, mount latency, intromission latency were significantly affected. Increase in body weight as well as weight of testis, prostate, seminal vesicle, and epididymis was noticed. Transverse sections of testis exhibited increased spermatogenesis and a significant increase in sperm count in epididymis. The fructose content of seminal vesicle was also increased. The extract treatment also brought a significant increase in serum testosterone and luteinizing hormone levels. The studies clearly reflect androgenic activity of the extract and its effects on hypothalamic pituitary gonadal axis.
[Mh] Termos MeSH primário: Bryonia/química
Extratos Vegetais/administração & dosagem
Sementes/química
Comportamento Sexual Animal/efeitos dos fármacos
[Mh] Termos MeSH secundário: Animais
Epididimo/citologia
Frutose/análise
Hormônio Luteinizante/sangue
Masculino
Tamanho do Órgão/efeitos dos fármacos
Próstata/anatomia & histologia
Ratos
Ratos Wistar
Glândulas Seminais/anatomia & histologia
Glândulas Seminais/química
Contagem de Espermatozoides
Espermatogênese
Testículo/anatomia & histologia
Testosterona/sangue
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Plant Extracts); 30237-26-4 (Fructose); 3XMK78S47O (Testosterone); 9002-67-9 (Luteinizing Hormone)
[Em] Mês de entrada:1008
[Cu] Atualização por classe:131121
[Lr] Data última revisão:
131121
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:091225
[St] Status:MEDLINE
[do] DOI:10.1038/ijir.2009.62


  10 / 19 MEDLINE  
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[PMID]:19120821
[Au] Autor:Oyama RK; Volz SM; Renner SS
[Ad] Endereço:Department of Biology, Ludwig-Maximilians-Universität, Munich, Germany. royama@lrz.uni-muenchen.de
[Ti] Título:A sex-linked SCAR marker in Bryonia dioica (Cucurbitaceae), a dioecious species with XY sex-determination and homomorphic sex chromosomes.
[So] Source:J Evol Biol;22(1):214-24, 2009 Jan.
[Is] ISSN:1420-9101
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Genetic crosses between the dioecious Bryonia dioica (Cucurbitaceae) and the monoecious B. alba in 1903 provided the first clear evidence for Mendelian inheritance of dioecy and made B. dioica the first organism for which XY sex-determination was experimentally proven. Applying molecular tools to this system, we developed a sex-linked sequence-characterized amplified region (SCAR) marker for B. dioica and sequenced it for individuals representing the full geographic range of the species from Scotland to North Africa. For comparison, we also sequenced this marker for representatives of the dioecious B. cretica, B. multiflora and B. syriaca, and monoecious B. alba. In no case did any individual, male or female, yield more than two haplotypes. In northern Europe, we found strong linkage between our marker and sex, with all Y-sequences being identical to each other. In southern Europe, however, the linkage between our marker and sex was weak, with recombination detected within both the X- and the Y-homologues. Population genetic analyses suggest that the SCAR marker experienced different evolutionary pressures in northern and southern Europe. These findings fit with phylogenetic evidence that the XY system in Bryonia is labile and suggest that the genus may be a good system in which to study the early steps of sex chromosome evolution.
[Mh] Termos MeSH primário: Bryonia/genética
Cromossomos de Plantas/genética
Cromossomos Sexuais/genética
Processos de Determinação Sexual
[Mh] Termos MeSH secundário: Bryonia/classificação
Evolução Molecular
Marcadores Genéticos
Variação Genética
Haplótipos
Filogenia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Genetic Markers)
[Em] Mês de entrada:0902
[Cu] Atualização por classe:101118
[Lr] Data última revisão:
101118
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:090106
[St] Status:MEDLINE
[do] DOI:10.1111/j.1420-9101.2008.01641.x



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