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Pesquisa : B01.650.940.800.575.912.250.300.140.500 [Categoria DeCS]
Referências encontradas : 20 [refinar]
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  1 / 20 MEDLINE  
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[PMID]:28646815
[Au] Autor:Kwiatkowski L; Rice E; Langland J
[Ti] Título:Integrative Treatment of Chronic Abdominal Bloating and Pain Associated With Overgrowth of Small Intestinal Bacteria: A Case Report.
[So] Source:Altern Ther Health Med;23(4):56-61, 2017 Jul.
[Is] ISSN:1078-6791
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Context • Small intestinal bacterial overgrowth (SIBO) is commonly defined as an increased number of bacteria and/or an abnormal type of bacteria in the small intestine. Conventional treatment for SIBO is typically focused on antibiotics to eradicate the bacterial overgrowth. Numerous studies have demonstrated the antimicrobial activity of herbs, and a diet low in fermentable oligo-, di-, and monosaccharides and polyols (FODMAPs) has been shown to enhance antibiotic therapy. Objective • The current case study intended to evaluate the benefits of an alternative, multifaceted approach-including botanical and homeopathic therapies in conjunction with a low-FODMAP diet-in the treatment of SIBO and its associated symptoms. Design • The research team performed a case study. Setting • The study was conducted at SCNM Medical Center (Tempe, AZ, USA). Participant • The participant was a female patient at the SCNM Medical Center with chronic, daily, severe abdominal bloating and pain that particularly worsened after meals and by the end of the day. The patient also had a significant history of chronic constipation that had begun approximately 10 y prior to her experiencing the daily abdominal pain. Intervention • Based on a lactulose breath test for hydrogen and methane, the research team diagnosed the patient with a case of mild SIBO. The treatment approach was multifaceted, involving a low-FODMAP diet, antimicrobial botanical therapy, and homeopathic medicine. Results • The patient's abdominal pain and bloating resolved with the treatment of the SIBO, although her underlying constipation, which was likely associated with other factors, remained. Conclusions • This case study supports an alternative, multifaceted approach to the treatment of SIBO and commonly associated symptoms.
[Mh] Termos MeSH primário: Síndrome da Alça Cega/terapia
Dietoterapia
Homeopatia
Fitoterapia
Probióticos/uso terapêutico
[Mh] Termos MeSH secundário: Dor Abdominal/etiologia
Adulto
Síndrome da Alça Cega/complicações
Síndrome da Alça Cega/diagnóstico
Testes Respiratórios
Doença Crônica
Citrullus colocynthis
Constipação Intestinal/complicações
Dissacarídeos
Feminino
Fermentação
Seres Humanos
Monossacarídeos
Oligossacarídeos
Polímeros
[Pt] Tipo de publicação:CASE REPORTS; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Disaccharides); 0 (Monosaccharides); 0 (Oligosaccharides); 0 (Polymers); 0 (polyol)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171024
[Lr] Data última revisão:
171024
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170625
[St] Status:MEDLINE


  2 / 20 MEDLINE  
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[PMID]:28609451
[Au] Autor:Hajjar D; Kremb S; Sioud S; Emwas AH; Voolstra CR; Ravasi T
[Ad] Endereço:KAUST Environmental Epigenetics Program, King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia.
[Ti] Título:Anti-cancer agents in Saudi Arabian herbals revealed by automated high-content imaging.
[So] Source:PLoS One;12(6):e0177316, 2017.
[Is] ISSN:1932-6203
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:Natural products have been used for medical applications since ancient times. Commonly, natural products are structurally complex chemical compounds that efficiently interact with their biological targets, making them useful drug candidates in cancer therapy. Here, we used cell-based phenotypic profiling and image-based high-content screening to study the mode of action and potential cellular targets of plants historically used in Saudi Arabia's traditional medicine. We compared the cytological profiles of fractions taken from Juniperus phoenicea (Arar), Anastatica hierochuntica (Kaff Maryam), and Citrullus colocynthis (Hanzal) with a set of reference compounds with established modes of action. Cluster analyses of the cytological profiles of the tested compounds suggested that these plants contain possible topoisomerase inhibitors that could be effective in cancer treatment. Using histone H2AX phosphorylation as a marker for DNA damage, we discovered that some of the compounds induced double-strand DNA breaks. Furthermore, chemical analysis of the active fraction isolated from Juniperus phoenicea revealed possible anti-cancer compounds. Our results demonstrate the usefulness of cell-based phenotypic screening of natural products to reveal their biological activities.
[Mh] Termos MeSH primário: Antineoplásicos/farmacologia
Ensaios de Triagem em Larga Escala/métodos
Preparações de Plantas/farmacologia
Inibidores da Topoisomerase/farmacologia
[Mh] Termos MeSH secundário: Antineoplásicos/química
Apoptose/efeitos dos fármacos
Brassicaceae/química
Caspase 9/metabolismo
Sobrevivência Celular/efeitos dos fármacos
Citrullus colocynthis/química
Quebras de DNA de Cadeia Dupla/efeitos dos fármacos
Dano ao DNA
Células HeLa
Histonas/metabolismo
Seres Humanos
Juniperus/química
Espectroscopia de Ressonância Magnética
Espectrometria de Massas/métodos
Estrutura Molecular
Fosforilação/efeitos dos fármacos
Preparações de Plantas/química
Arábia Saudita
Inibidores da Topoisomerase/química
Proteína Supressora de Tumor p53/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (H2AFX protein, human); 0 (Histones); 0 (Plant Preparations); 0 (Topoisomerase Inhibitors); 0 (Tumor Suppressor Protein p53); EC 3.4.22.- (Caspase 9)
[Em] Mês de entrada:1710
[Cu] Atualização por classe:171002
[Lr] Data última revisão:
171002
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170614
[St] Status:MEDLINE
[do] DOI:10.1371/journal.pone.0177316


  3 / 20 MEDLINE  
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[PMID]:28212344
[Au] Autor:Azizi S; Mohamad R; Mahdavi Shahri M
[Ad] Endereço:Department of Bioprocess Technology, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, UPM Serdang, Selangor 43400, Malaysia. azisusan@gmail.com.
[Ti] Título:Green Microwave-Assisted Combustion Synthesis of Zinc Oxide Nanoparticles with Citrullus colocynthis (L.) Schrad: Characterization and Biomedical Applications.
[So] Source:Molecules;22(2), 2017 Feb 16.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:In this paper, a green microwave-assisted combustion approach to synthesize ZnO-NPs using zinc nitrate and (L.) Schrad (fruit, seed and pulp) extracts as bio-fuels is reported. The structure, optical, and colloidal properties of the synthesized ZnO-NP samples were studied. Results illustrate that the morphology and particle size of the ZnO samples are different and depend on the bio-fuel. The XRD results revealed that hexagonal wurtzite ZnO-NPs with mean particle size of 27-85 nm were produced by different bio-fuels. The optical band gap was increased from 3.25 to 3.40 eV with the decreasing of particle size. FTIR results showed some differences in the surface structures of the as-synthesized ZnO-NP samples. This led to differences in the zeta potential, hydrodynamic size, and more significantly, antioxidant activity through scavenging of 1, 1-Diphenyl-2-picrylhydrazyl (DPPH) free radicals. In in vitro cytotoxicity studies on 3T3 cells, a dose dependent toxicity with non-toxic effect of concentration below 0.26 mg/mL was shown for ZnO-NP samples. Furthermore, the as-synthesized ZnO-NPs inhibited the growth of medically significant pathogenic gram-positive ( and Methicillin-resistant ) and gram-negative ( and ) bacteria. This study provides a simple, green and efficient approach to produce ZnO nanoparticles for various applications.
[Mh] Termos MeSH primário: Citrullus colocynthis/química
Química Verde
Micro-Ondas
Nanopartículas/química
Extratos Vegetais/química
Óxido de Zinco/química
[Mh] Termos MeSH secundário: Animais
Antibacterianos/química
Antibacterianos/farmacologia
Antioxidantes/química
Antioxidantes/farmacologia
Linhagem Celular
Sobrevivência Celular/efeitos dos fármacos
Coloides
Camundongos
Testes de Sensibilidade Microbiana
Estrutura Molecular
Nanopartículas/ultraestrutura
Espectroscopia de Infravermelho com Transformada de Fourier
Difração de Raios X
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Bacterial Agents); 0 (Antioxidants); 0 (Colloids); 0 (Plant Extracts); SOI2LOH54Z (Zinc Oxide)
[Em] Mês de entrada:1705
[Cu] Atualização por classe:170509
[Lr] Data última revisão:
170509
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170218
[St] Status:MEDLINE


  4 / 20 MEDLINE  
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[PMID]:27134068
[Au] Autor:Somorin Y; Akinyemi A; Bertuzzi T; Pietri A
[Ad] Endereço:a Discipline of Microbiology, School of Natural Sciences , National University of Ireland , Galway , Ireland.
[Ti] Título:Co-occurrence of aflatoxins, ochratoxin A and citrinin in "egusi" melon (Colocynthis citrullus L.) seeds consumed in Ireland and the United Kingdom.
[So] Source:Food Addit Contam Part B Surveill;9(3):230-5, 2016 Sep.
[Is] ISSN:1939-3229
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:The natural co-occurrence of aflatoxins (AFs), ochratoxin A (OTA) and citrinin (CIT) in melon seed samples obtained from retailers and households in Ireland and the United Kingdom (UK) was evaluated. AFs and OTA were determined by HPLC with fluorescence detection while CIT was analysed by HPLC-MS/MS. AFB1 was detected in all (100%) samples (mean = 9.7 µg kg(-1); range = 0.2-66.5 µg kg(-1)). Mean total AFs was 12.0 µg kg(-1) (range = 0.3-82 µg kg(-1)). Commercially retailed samples showed a significantly higher AFB1 contamination (p < 0.05) than the household samples. OTA occurred in 3 (13.6%) samples, while 4 (18.2%) were contaminated with CIT at very low levels. In this study, 68% of the melon seed samples were contaminated above the 2 µg kg(-1) EU limit for AFB1 in oilseeds. These results highlight the need for the development of strategies to reduce AF contamination in "egusi" for human consumption.
[Mh] Termos MeSH primário: Aflatoxinas/análise
Citrinina/análise
Citrullus colocynthis/química
Contaminação de Alimentos
Ocratoxinas/análise
Sementes/química
Lanches
[Mh] Termos MeSH secundário: Aflatoxinas/toxicidade
Citrinina/toxicidade
Citrullus colocynthis/efeitos adversos
Dieta/efeitos adversos
Dieta/normas
Poluentes Ambientais/análise
Poluentes Ambientais/toxicidade
União Europeia
Contaminação de Alimentos/prevenção & controle
Manipulação de Alimentos
Inspeção de Alimentos
Embalagem de Alimentos
Armazenamento de Alimentos
Seres Humanos
Internacionalidade
Irlanda
Legislação sobre Alimentos
Ocratoxinas/toxicidade
Sementes/efeitos adversos
Reino Unido
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Aflatoxins); 0 (Environmental Pollutants); 0 (Ochratoxins); 1779SX6LUY (ochratoxin A); 3S697X6SNZ (Citrinin)
[Em] Mês de entrada:1704
[Cu] Atualização por classe:170413
[Lr] Data última revisão:
170413
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160503
[St] Status:MEDLINE
[do] DOI:10.1080/19393210.2016.1183051


  5 / 20 MEDLINE  
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[PMID]:26942486
[Au] Autor:Khan MB; Khan H; Shah MU; Khan S
[Ad] Endereço:a Department of Bioscience , COMSATS Institute of Information Technology Islamabad , Pakistan.
[Ti] Título:Purification and biochemical properties of SDS-stable low molecular weight alkaline serine protease from Citrullus colocynthis.
[So] Source:Nat Prod Res;30(8):935-40, 2016.
[Is] ISSN:1478-6427
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:A low molecular weight serine protease from seeds of Citrullus colocynthis was purified to electrophoretic homogeneity with high level of catalytic efficiency (22,945 M(-1) S(-1)). The enzyme was a monomer with molecular mass of 25 kDa estimated by SDS-PAGE. The enzyme was highly active over a pH range of 6.5-9.0 and temperature range of 20-80 °C, with maximum activity at pH 7.5 and at 50 °C. The K(m) and K(cat) were 73 µg/mL and 67/s, respectively. The enzyme was strongly inhibited by PMSF, moderately by soybean trypsin inhibitor, indicating that the enzyme was a serine protease. The enzyme retained 86 and 73% of its activity in the presence of urea and DTT, respectively, and its activity was slightly enhanced in the presence of anionic detergent (SDS). Thus, the enzyme is a novel SDS-stable protease with high catalytic efficiency over wide ranges of pH and temperature which is commercially promising for various industrial applications.
[Mh] Termos MeSH primário: Citrullus colocynthis/enzimologia
Serina Proteases/química
[Mh] Termos MeSH secundário: Eletroforese em Gel de Poliacrilamida
Estabilidade Enzimática
Concentração de Íons de Hidrogênio
Peso Molecular
Sementes/química
Serina Proteases/isolamento & purificação
Especificidade por Substrato
Temperatura Ambiente
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
EC 3.4.- (Serine Proteases)
[Em] Mês de entrada:1611
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160305
[St] Status:MEDLINE
[do] DOI:10.1080/14786419.2015.1079909


  6 / 20 MEDLINE  
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[PMID]:26826821
[Au] Autor:Shaikh J; Shaikh D; Rahman AB; Shafi S
[Ad] Endereço:50, Guion Place New Rochelle NY, USA.
[Ti] Título:Antimicrobial and toxicological studies on fruit pulp of Citrullus colocynthis L.
[So] Source:Pak J Pharm Sci;29(1):9-15, 2016 Jan.
[Is] ISSN:1011-601X
[Cp] País de publicação:Pakistan
[La] Idioma:eng
[Ab] Resumo:The methanolic extract of dried fruit pulp of Citrullus colocyn this (Cucurbitaceae) has been studied with respect to antimicrobial and toxicological properties. The antimicrobial profile was investigated against thirty bacterial isolates (10 Gram +ve and 20 Gram-ve) and five fungal species. None of the bacterial or fungal culture used in the study showed sensitivity against the extract. Acute toxicity studies carried out in Albino mice NMRI indicated the highly toxic nature of the colocynth. A very significant decrease in body weight of test animals was noted at P<0.05. The LD(50) was calculated as 1000mg/kg body weight. Within four days of experimentation mortality was 100%. Histopathological studies confirmed the toxic nature of extract. Gross changes in histology of Heart, Liver and Kidneys were noted. Section of spleen did not exhibit any abnormality.
[Mh] Termos MeSH primário: Anti-Infecciosos/farmacologia
Citrullus colocynthis
Extratos Vegetais/farmacologia
[Mh] Termos MeSH secundário: Animais
Feminino
Frutas
Rim/efeitos dos fármacos
Rim/patologia
Fígado/efeitos dos fármacos
Fígado/patologia
Masculino
Camundongos
Extratos Vegetais/toxicidade
Baço/efeitos dos fármacos
Baço/patologia
Testes de Toxicidade Aguda
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anti-Infective Agents); 0 (Plant Extracts)
[Em] Mês de entrada:1604
[Cu] Atualização por classe:160201
[Lr] Data última revisão:
160201
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160201
[St] Status:MEDLINE


  7 / 20 MEDLINE  
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[PMID]:26634927
[Au] Autor:Mehrzadi S; Shojaii A; Pur SA; Motevalian M
[Ad] Endereço:Razi Drug Research Center, Department of Pharmacology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
[Ti] Título:Anticonvulsant Activity of Hydroalcoholic Extract of Citrullus colocynthis Fruit: Involvement of Benzodiazepine and Opioid Receptors.
[So] Source:J Evid Based Complementary Altern Med;21(4):NP31-5, 2016 Oct.
[Is] ISSN:2156-5899
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:This study investigated the anticonvulsant activity of Citrullus colocynthis fruit extract used traditionally in the treatment of convulsion. Albino mice were pretreated with extract in different doses (10, 25, 50, and 100 mg/kg), prior to injection of pentylenetetrazole. Animals received pretreatments with naloxone and flumazenil to further clarify the mechanisms of anticonvulsant action. The total flavonoid content of Citrullus colocynthis extract was also determined. Citrullus colocynthis hydroalcoholic extract with doses 25 and 50 mg/kg prolonged the onset of seizures and decreased the duration compared with control group. Pretreatment by flumazenil could inhibit the effect of Citrullus colocynthis on latency of seizure to some extent and administration of naloxone significantly inhibited changes in latency and duration of seizure produced by Citrullus colocynthis This study showed that Citrullus colocynthis has significant anticonvulsant effect in pentylenetetrazole-induced seizures in mice, and these effects may be related to its effect on γ-aminobutyric acid-ergic and opioid systems. These results confirmed the traditional use of Citrullus colocynthis in Iranian traditional medicine.
[Mh] Termos MeSH primário: Anticonvulsivantes/farmacologia
Citrullus colocynthis/química
Extratos Vegetais/farmacologia
Receptores Opioides/metabolismo
Convulsões/tratamento farmacológico
[Mh] Termos MeSH secundário: Animais
Anticonvulsivantes/química
Anticonvulsivantes/uso terapêutico
Benzodiazepinas
Flavonoides
Flumazenil
Frutas/química
Interações Ervas-Drogas
Masculino
Medicina Arábica
Camundongos
Naloxona
Pentilenotetrazol
Extratos Vegetais/química
Extratos Vegetais/uso terapêutico
Convulsões/induzido quimicamente
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Anticonvulsants); 0 (Flavonoids); 0 (Plant Extracts); 0 (Receptors, Opioid); 12794-10-4 (Benzodiazepines); 36B82AMQ7N (Naloxone); 40P7XK9392 (Flumazenil); WM5Z385K7T (Pentylenetetrazole)
[Em] Mês de entrada:1706
[Cu] Atualização por classe:170626
[Lr] Data última revisão:
170626
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151205
[St] Status:MEDLINE
[do] DOI:10.1177/2156587215615455


  8 / 20 MEDLINE  
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[PMID]:25800045
[Au] Autor:Heydari M; Homayouni K; Hashempur MH; Shams M
[Ad] Endereço:Research Center for Traditional Medicine and History of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
[Ti] Título:Topical Citrullus colocynthis (bitter apple) extract oil in painful diabetic neuropathy: A double-blind randomized placebo-controlled clinical trial.
[So] Source:J Diabetes;8(2):246-52, 2016 Mar.
[Is] ISSN:1753-0407
[Cp] País de publicação:Australia
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: The aim of the present study was to examine the safety and efficacy of a topical formulation of Citrullus colocynthis in patients with painful diabetic polyneuropathy (PDPN). METHODS: The study was designed as a two-arm double-blind randomized placebo-controlled clinical trial using a parallel design. Sixty patients with PDPN were randomly allocated to receive either a topical formulation of C. colocynthis or placebo (1:1 allocation ratio) for 3 months. Patients were evaluated before and after the intervention using the neuropathic pain scale, electrodiagnostic findings, World Health Organization Biomedical Research and Education Foundation (BREF) quality of life (WHOQOL-BREF) scores, and reported adverse events. RESULTS: There was a significantly greater decrease in mean pain score after 3 months in the C. colocynthis (-3.89; 95% confidence interval [CI] -3.19, -4.60) than placebo (-2.28; 95% CI -1.66, -2.90) group (P < 0.001). Mean changes in nerve conduction velocity of the tibial nerve, distal latency of the superficial peroneal nerve and sural nerve, and sensory amplitude of the sural nerve were significantly higher in the intervention than placebo group (P < 0.001) in favour of the intervention. In the different domains of WHOQOL-BREF, there was a significant improvement only for the mean score in the physical domain. CONCLUSIONS: Application of a topical formulation of C. colocynthis fruit extract can decrease pain in patients with PDPN. It also may have some uncertain effects on nerve function and the physical domain of quality of life, which require further investigation in studies with larger sample sizes and of longer duration.
[Mh] Termos MeSH primário: Citrullus colocynthis/química
Neuropatias Diabéticas/tratamento farmacológico
Neuralgia/tratamento farmacológico
Extratos Vegetais/uso terapêutico
[Mh] Termos MeSH secundário: Administração Cutânea
Adulto
Idoso
Neuropatias Diabéticas/complicações
Neuropatias Diabéticas/fisiopatologia
Método Duplo-Cego
Feminino
Seres Humanos
Masculino
Meia-Idade
Condução Nervosa/efeitos dos fármacos
Neuralgia/etiologia
Neuralgia/fisiopatologia
Medição da Dor/métodos
Nervo Fibular/efeitos dos fármacos
Nervo Fibular/fisiopatologia
Fitoterapia/métodos
Qualidade de Vida
Nervo Sural/efeitos dos fármacos
Nervo Sural/fisiopatologia
Nervo Tibial/efeitos dos fármacos
Nervo Tibial/fisiopatologia
Resultado do Tratamento
[Pt] Tipo de publicação:JOURNAL ARTICLE; RANDOMIZED CONTROLLED TRIAL; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Plant Extracts)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150325
[St] Status:MEDLINE
[do] DOI:10.1111/1753-0407.12287


  9 / 20 MEDLINE  
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[PMID]:26665406
[Au] Autor:Li Y; Zheng M; Zhai X; Huang Y; Khalid A; Malik A; Shah P; Karim S; Azhar S; Hou X
[Ti] Título:EFFECT OF-GYMNEMA SYLVESTRE, CITRULLUS COLOCYNTHIS AND ARTEMISIA ABSINTHIUM ON BLOOD GLUCOSE AND LIPID PROFILE IN DIABETIC HUMAN.
[So] Source:Acta Pol Pharm;72(5):981-5, 2015 Sep-Oct.
[Is] ISSN:0001-6837
[Cp] País de publicação:Poland
[La] Idioma:eng
[Ab] Resumo:The aim of this study was to manage diabetes with medicinal plants (Gymnema sylvestre, Artemisia absinthium and Citillus colocynthis) in human patients with type II diabetes. Thirty two patients of type II diabetes from both sexes of 30-60 years age were registered for this study and distributed them into four groups, each having 8 patients. Capsules of each, Gymnema sylvestre, Artemisia absinthium and Citrullus colocynthis were given to patients twice a day for 30 days in 1 g per day dosage and investigated for glucose, triglyceride (TGL) and cholesterol level. Gymnema sylvestre reduced 37% glucose, 5% TGL, 13% cholesterol and 19% low desity lipoproteins (LDL) level in diabetic individuals. Citrullus colocynth reduced glucose, cholesterol and TGL and HDL-cholesterol level by 35, 6, 6, and 5%, respectively. Artemisia absinthium reduced 3% high desity lipoproteins (HDL) and 6% LDL level. From results, it can be concluded that the powdered Gymnema sylvestre, Citrulus colocynthis, and Artemisia absinthium possess good anti-diabetic features, however these herbal products had no significant effect on lipid profiles of the diabetic human.
[Mh] Termos MeSH primário: Artemisia absinthium
Glicemia/análise
Citrullus colocynthis
Diabetes Mellitus Tipo 2/tratamento farmacológico
Gymnema sylvestre
Fitoterapia
[Mh] Termos MeSH secundário: Adulto
Diabetes Mellitus Tipo 2/sangue
Feminino
Seres Humanos
Lipoproteínas HDL/sangue
Lipoproteínas LDL/sangue
Masculino
Meia-Idade
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Blood Glucose); 0 (Lipoproteins, HDL); 0 (Lipoproteins, LDL)
[Em] Mês de entrada:1601
[Cu] Atualização por classe:151210
[Lr] Data última revisão:
151210
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151216
[St] Status:MEDLINE


  10 / 20 MEDLINE  
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[PMID]:26437392
[Au] Autor:Chawech R; Jarraya R; Girardi C; Vansteelandt M; Marti G; Nasri I; Racaud-Sultan C; Fabre N
[Ad] Endereço:Université de Toulouse, UPS, Pharma-DEV, UMR 152, Université Toulouse 3, Faculté des Sciences Pharmaceutiques, F-31062 Toulouse cedex 09, France. chawech.rachid@gmail.com.
[Ti] Título:Cucurbitacins from the Leaves of Citrullus colocynthis (L.) Schrad.
[So] Source:Molecules;20(10):18001-15, 2015 Sep 30.
[Is] ISSN:1420-3049
[Cp] País de publicação:Switzerland
[La] Idioma:eng
[Ab] Resumo:Two new tetracyclic cucurbitane-type triterpene glycosides were isolated from an ethyl acetate extract of Citrullus colocynthis leaves together with four known cucurbitacins. Their structures were established on the basis of their spectroscopic data (mainly NMR and mass spectrometry). Evaluation of the in vitro cytotoxic activity of the isolated compounds against two human colon cancer cell lines (HT29 and Caco-2) and one normal rat intestine epithelial cell line (IEC6), revealed that one of the isolated compounds presented interesting specific cytotoxic activity towards colorectal cell lines.
[Mh] Termos MeSH primário: Citrullus colocynthis/química
Cucurbitacinas/química
Extratos Vegetais/química
Folhas de Planta/química
[Mh] Termos MeSH secundário: Antineoplásicos Fitogênicos/química
Antineoplásicos Fitogênicos/farmacologia
Linhagem Celular Tumoral
Cucurbitacinas/farmacologia
Relação Dose-Resposta a Droga
Seres Humanos
Concentração Inibidora 50
Estrutura Molecular
Ressonância Magnética Nuclear Biomolecular
Extratos Vegetais/farmacologia
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Plant Extracts); 60137-06-6 (Cucurbitacins)
[Em] Mês de entrada:1606
[Cu] Atualização por classe:151006
[Lr] Data última revisão:
151006
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151006
[St] Status:MEDLINE
[do] DOI:10.3390/molecules201018001



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