Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.300.827 [Categoria DeCS]
Referências encontradas : 138 [refinar]
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[PMID]:29441920
[Ti] Título:Pancreatic lipase and -amylase inhibitory activities of plants used in Traditional Chinese Medicine (TCM).
[So] Source:Pharmazie;71(7):420-424, 2016 Jul 07.
[Is] ISSN:0031-7144
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:To find new, plant based drugs for the treatment of obesity and/or diabetes mellitus type 2 through the inhibition of essential digestive enzymes, in vitro tests were carried out on selected plants or fungi with weight-reducing, blood glucose-reducing or related potential, used in Traditional Chinese Medicine (TCM). Aqueous and methanolic extracts of 32 Chinese herbal medicines were assayed for their in vitro inhibitory activity against pancreatic lipase (PL) and α-amylase (PA). PL activity was measured by using an enzymatic in vitro assay based on the hydrolysis kinetics of an oleate ester of 4-methylumbelliferone. For the determination of α-amylase activity an enzyme assay based on the hydrolytic cleavage of a modified starch derivative was used. Our findings have shown that the methanolic extract of Lycopus lucidus Turcz. var. hirtus Regel (Lamiaceae) was a very effective PL inhibitor (IC50: 88.3±4.1 µg/mL). A high anti-amylase activity showed the methanolic extract of Trichosanthes kirilowii Maxim. (Curcurbitaceae, IC50: 248.8±67.3 µg/mL). This work provides a priority list of interesting plants for further study with respect to the treatment of obesity and associated metabolic diseases.
[Mh] Termos MeSH primário: Lipase/antagonistas & inibidores
Pâncreas/enzimologia
Plantas/química
alfa-Amilases/antagonistas & inibidores
[Mh] Termos MeSH secundário: Fungos/química
Hidrólise
Himecromona/química
Cinética
Lycopus/química
Medicina Tradicional Chinesa
Pâncreas/efeitos dos fármacos
Extratos Vegetais/farmacologia
Trichosanthes/química
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Plant Extracts); 3T5NG4Q468 (Hymecromone); EC 3.1.1.3 (Lipase); EC 3.2.1.1 (alpha-Amylases)
[Em] Mês de entrada:1803
[Cu] Atualização por classe:180308
[Lr] Data última revisão:
180308
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:180215
[St] Status:MEDLINE
[do] DOI:10.1691/ph.2016.6569


  2 / 138 MEDLINE  
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[PMID]:28615015
[Au] Autor:Karunakaran R; Ira Thabrew M; Thammitiyagodage GM; Galhena BP; Menuka Arawwawala LDA
[Ad] Endereço:Medical Research Institute, Dr. Danister de Silva Mawatha, Colombo, 08, Sri Lanka.
[Ti] Título:The gastroprotective effect of ethyl acetate fraction of hot water extract of Trichosanthes cucumerina Linn and its underlying mechanisms.
[So] Source:BMC Complement Altern Med;17(1):312, 2017 Jun 14.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Antacids, anticholinergic drugs, histamine H2- receptor antagonists and irreversible proton pump inhibitors have been used for the treatment of gastric ulcers. However, prolonged use of these drugs may lead to series of adverse effects such as diarrhea, headache, rash, hypertension, muscular and joint pain. Therefore, there is an urgent need of more effective and safer treatments with fewer side effects. The aim of the present study was to scientifically evaluate the gastroprotective activity of fractions of the hot water extract of Trichosanthes cucumerina Linn (Family: Cucurbitaceae) aerial parts with a view to identifying the fraction with the best gastroprotective activity and the possible mechanism/s by which this fraction exert gastroprotection. METHODS: Gastroprotective activity of hexane fraction (HF), ethyl acetate fraction (EF), butanol fraction (BF) and aqueous fraction (AF) were evaluated by the assessment of ability to reduce the ulcer index in ethanol-induced rat model and the mode of action by which the most active fraction mediating gastroprotection. RESULTS: EF showed the maximum gastroprotection effect followed by BF and AF. EF (75 mg/kg) exhibited significantly higher gastroprotection compared to the reference drugs. Further investigations with two lower doses of EF confirmed that EF can mediated a significant and dose dependent gastroprotection. The rats treated with the EF showed significant reduction in free acidity (45%), total acidity (by 48%) in the gastric juice, increased the amount of mucus produced by the rat gastro mucosa and potent antihistamine activity (by 25.6%). EF was also rich in phenolic compounds and flavonoids. CONCLUSION: Gastroprotective mechanism of EF is possibly involves inhibition of acidity, elevation in mucus content, inhibition of histamine and antioxidant mechanisms.
[Mh] Termos MeSH primário: Extratos Vegetais/administração & dosagem
Substâncias Protetoras/administração & dosagem
Úlcera Gástrica/tratamento farmacológico
Trichosanthes/química
[Mh] Termos MeSH secundário: Animais
Antioxidantes/metabolismo
Suco Gástrico/metabolismo
Mucosa Gástrica/efeitos dos fármacos
Mucosa Gástrica/metabolismo
Seres Humanos
Masculino
Extratos Vegetais/química
Extratos Vegetais/isolamento & purificação
Substâncias Protetoras/química
Substâncias Protetoras/isolamento & purificação
Ratos Wistar
Úlcera Gástrica/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 0 (Plant Extracts); 0 (Protective Agents)
[Em] Mês de entrada:1708
[Cu] Atualização por classe:170821
[Lr] Data última revisão:
170821
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170616
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-1796-y


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[PMID]:28100206
[Au] Autor:Lo HY; Li TC; Yang TY; Li CC; Chiang JH; Hsiang CY; Ho TY
[Ad] Endereço:Graduate Institute of Chinese Medicine, China Medical University, 91 Hsueh-Shih Road, Taichung, 40402, Taiwan.
[Ti] Título:Hypoglycemic effects of Trichosanthes kirilowii and its protein constituent in diabetic mice: the involvement of insulin receptor pathway.
[So] Source:BMC Complement Altern Med;17(1):53, 2017 Jan 18.
[Is] ISSN:1472-6882
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Diabetes is a serious chronic metabolic disorder. Trichosanthes kirilowii Maxim. (TK) is traditionally used for the treatment of diabetes in traditional Chinese medicine (TCM). However, the clinical application of TK on diabetic patients and the hypoglycemic efficacies of TK are still unclear. METHODS: A retrospective cohort study was conducted to analyze the usage of Chinese herbs in patients with type 2 diabetes in Taiwan. Glucose tolerance test was performed to analyze the hypoglycemic effect of TK. Proteomic approach was performed to identify the protein constituents of TK. Insulin receptor (IR) kinase activity assay and glucose tolerance tests in diabetic mice were further used to elucidate the hypoglycemic mechanisms and efficacies of TK. RESULTS: By a retrospective cohort study, we found that TK was the most frequently used Chinese medicinal herb in type 2 diabetic patients in Taiwan. Oral administration of aqueous extract of TK displayed hypoglycemic effects in a dose-dependent manner in mice. An abundant novel TK protein (TKP) was further identified by proteomic approach. TKP interacted with IR by docking analysis and activated the kinase activity of IR. In addition, TKP enhanced the clearance of glucose in diabetic mice in a dose-dependent manner. CONCLUSIONS: In conclusion, this study applied a bed-to-bench approach to elucidate the hypoglycemic efficacies and mechanisms of TK on clinical usage. In addition, we newly identified a hypoglycemic protein TKP from TK. Our findings might provide a reasonable explanation of TK on the treatment of diabetes in TCM.
[Mh] Termos MeSH primário: Diabetes Mellitus Tipo 2/tratamento farmacológico
Medicamentos de Ervas Chinesas/uso terapêutico
Hipoglicemiantes/uso terapêutico
Receptor de Insulina/metabolismo
Trichosanthes/química
[Mh] Termos MeSH secundário: Animais
Estudos de Coortes
Diabetes Mellitus Experimental/tratamento farmacológico
Feminino
Seres Humanos
Masculino
Camundongos
Camundongos Endogâmicos BALB C
Camundongos Endogâmicos C57BL
Proteínas de Plantas/uso terapêutico
Estudos Retrospectivos
Taiwan
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Drugs, Chinese Herbal); 0 (Hypoglycemic Agents); 0 (Plant Proteins); EC 2.7.10.1 (Receptor, Insulin)
[Em] Mês de entrada:1701
[Cu] Atualização por classe:170220
[Lr] Data última revisão:
170220
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:170120
[St] Status:MEDLINE
[do] DOI:10.1186/s12906-017-1578-6


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[PMID]:27855888
[Au] Autor:Bamidele OP; Fasogbon MB
[Ad] Endereço:Federal Polytechnic Offa, Kwara State, Nigeria; Department of Food Science and Technology, Obafemi Awolowo University, Ile-Ife, Nigeria. Electronic address: bampet2001@yahoo.co.uk.
[Ti] Título:Chemical and antioxidant properties of snake tomato (Trichosanthes cucumerina) juice and Pineapple (Ananas comosus) juice blends and their changes during storage.
[So] Source:Food Chem;220:184-189, 2017 Apr 01.
[Is] ISSN:0308-8146
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Juice blends made from the mixture of snake tomato (Trichosanthes cucumerina) and Pineapple (Ananas comosus) fruits were analyzed for pH, antioxidant properties, total titratable acidity, vitamin C, lycopene and total phenolic contents after different blend ratios were made. The addition of snake tomato juice increased the vitamin C, total carotene, lycopene and antioxidant properties of the juice blends. The radical scavenging properties of juice blends containing a higher ratio of snake tomato were higher and samples stored at room temperature (29°C) showed an increase in antioxidant properties compared to samples stored at 4°C. In conclusion, snake tomato juice up to 50% may be added to Pineapple juice to make a healthy juice blend.
[Mh] Termos MeSH primário: Ananas/química
Antioxidantes/farmacologia
Sucos de Frutas e Vegetais/análise
Trichosanthes/química
[Mh] Termos MeSH secundário: Ácido Ascórbico/análise
Carotenoides/análise
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antioxidants); 36-88-4 (Carotenoids); PQ6CK8PD0R (Ascorbic Acid); SB0N2N0WV6 (lycopene)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:161119
[St] Status:MEDLINE


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[PMID]:27225069
[Au] Autor:Ye X; Ng CC; Wong JH; Ng TB; Chan GH; Guan S; Sha O
[Ad] Endereço:Key Laboratory of Biopesticide and Chemical Biology, Ministry of Education, and Key Laboratory of Plant Virology of Fujian Province, Institute of Plant Virology, Fujian Agriculture and Forestry University, Fuzhou, Fujian, China. 2578754211@qq.com.
[Ti] Título:Ribosome-inactivating Proteins from Root Tubers and Seeds of Trichosan-thes kirilowii and Other Trichosanthes Species.
[So] Source:Protein Pept Lett;23(8):699-706, 2016.
[Is] ISSN:1875-5305
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Ribosome-inactivating proteins have been isolated from Trichosanthes kirilowii root tubers and seeds, including trichosanthin, karasurin and T 33 from root tubers and trichosanthrip, trichokirin, alpha-kirilowin, beta-kirilowin and trichoanguin from seeds. The aforementioned proteins show structural and functional similarities. Among them trichosanthin is the best known and most intensely studied. Trichosanthin manifests anticancer activity in vitro and in tumor bearing mice against a variety of cancers/cancer cell lines. It also exhibits anti-HIV-1 and anti-HSV-1 activities. Trichosanthin has been found to be useful for treatment of cesarean scar pregnancies and ectopic pregnancy, and for preventing acute rejection of major histocompatibility complex-mismatched mouse skin allograft. Trichosanthin selectively lesions some neurons and thus can be used in neuroscience research.
[Mh] Termos MeSH primário: Proteínas Inativadoras de Ribossomos/química
Proteínas Inativadoras de Ribossomos/farmacologia
Trichosanthes/metabolismo
[Mh] Termos MeSH secundário: Animais
Antineoplásicos/química
Antineoplásicos/farmacologia
Cesárea/efeitos adversos
Cicatriz/tratamento farmacológico
Cicatriz/etiologia
Feminino
Rejeição de Enxerto
Seres Humanos
Camundongos
Proteínas de Plantas/química
Proteínas de Plantas/farmacologia
Raízes de Plantas/metabolismo
Gravidez
Sementes/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; REVIEW
[Nm] Nome de substância:
0 (Antineoplastic Agents); 0 (Plant Proteins); EC 3.2.2.22 (Ribosome Inactivating Proteins)
[Em] Mês de entrada:1703
[Cu] Atualização por classe:170321
[Lr] Data última revisão:
170321
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160527
[St] Status:MEDLINE


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[PMID]:26673746
[Au] Autor:Song L; Chang J; Li Z
[Ad] Endereço:Institute of Biotechnology, Key Laboratory of Chemical Biology and Molecular Engineering of National Ministry of Education, Shanxi University, Taiyuan 030006, China. lzy@sxu.edu.cn.
[Ti] Título:A serine protease extracted from Trichosanthes kirilowii induces apoptosis via the PI3K/AKT-mediated mitochondrial pathway in human colorectal adenocarcinoma cells.
[So] Source:Food Funct;7(2):843-54, 2016 Feb.
[Is] ISSN:2042-650X
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:Trichosanthes kirilowii exhibits various biological functions including anti-inflammatory, antidiabetic and anticancer activities. In this study, a novel protein with anti-cancer activity, named as TKP, was purified from Trichosanthes kirilowii fruit by cell-base screening. Mass spectrometry and protease assays revealed that TKP is a serine protease. TKP decreased cell viability in a concentration-and time-dependent manner in human colorectal adenocarcinoma cells. Notably, TKP presented very little effect on human colon epithelial cell line NCM460. Furthermore, TKP inhibited colorectal adenocarcinoma cells to aggregate into viable colony clusters and induced cell apoptosis. The loss of mitochondrial membrane potential, upregulation of cytochrome c and Bax, downregulation of Bcl-2, and activation of caspase-9 and -3 were observed, indicating mitochondria-dependent apoptosis induced by TKP. We found that TKP activated MAPK/ERK and suppressed PI3K/AKT signaling. Inhibition of MAPK/ERK signaling by employing inhibitor PD98059 did not antagonize the effects of TKP. Treatment with PI3K inhibitor LY294003 increased the impact of TKP on mitochondria-related apoptosis proteins (cytochrome c, Bcl-2, Bax, caspase-9 and caspase-3) and cell apoptosis. On the contrary, PI3K/AKT activator insulin-like growth factor-1 reversed the effects of TKP. Taken together, our results demonstrated that TKP has potential anti-colorectal cancer activity by inducing apoptosis, which was regulated by the PI3K/AKT-mediated mitochondria-dependent pathway.
[Mh] Termos MeSH primário: Apoptose/efeitos dos fármacos
Mitocôndrias/efeitos dos fármacos
Fosfatidilinositol 3-Quinases/metabolismo
Proteínas Proto-Oncogênicas c-akt/metabolismo
Serina Proteases/farmacologia
Trichosanthes/enzimologia
[Mh] Termos MeSH secundário: Caspase 3/genética
Caspase 3/metabolismo
Caspase 9/genética
Caspase 9/metabolismo
Linhagem Celular Tumoral
Sobrevivência Celular/efeitos dos fármacos
Neoplasias Colorretais/tratamento farmacológico
Citocromos c/genética
Citocromos c/metabolismo
Regulação para Baixo
Seres Humanos
Potencial da Membrana Mitocondrial/efeitos dos fármacos
Proteínas de Plantas/isolamento & purificação
Proteínas de Plantas/farmacologia
Serina Proteases/isolamento & purificação
Transdução de Sinais
Regulação para Cima
Proteína X Associada a bcl-2/genética
Proteína X Associada a bcl-2/metabolismo
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (BAX protein, human); 0 (Plant Proteins); 0 (bcl-2-Associated X Protein); 9007-43-6 (Cytochromes c); EC 2.7.1.- (Phosphatidylinositol 3-Kinases); EC 2.7.11.1 (Proto-Oncogene Proteins c-akt); EC 3.4.- (Serine Proteases); EC 3.4.22.- (CASP3 protein, human); EC 3.4.22.- (CASP9 protein, human); EC 3.4.22.- (Caspase 3); EC 3.4.22.- (Caspase 9)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151218
[St] Status:MEDLINE
[do] DOI:10.1039/c5fo00760g


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[PMID]:26666429
[Au] Autor:Kabir SR; Rahman MM; Tasnim S; Karim MR; Khatun N; Hasan I; Amin R; Islam SS; Nurujjaman M; Kabir AH; Sana NK; Ozeki Y; Asaduzzaman AK
[Ad] Endereço:Department of Biochemistry and Molecular Biology, Rajshahi University, Rajshahi 6205, Bangladesh. Electronic address: rashelkabir@ru.ac.bd.
[Ti] Título:Purification and characterization of a novel chitinase from Trichosanthes dioica seed with antifungal activity.
[So] Source:Int J Biol Macromol;84:62-8, 2016 Mar.
[Is] ISSN:1879-0003
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:Chitinases are a group of enzymes that show differences in their molecular structure, substrate specificity, and catalytic mechanism and widely found in organisms like bacteria, yeasts, fungi, arthropods actinomycetes, plants and humans. A novel chitinase enzyme (designated as TDSC) was purified from Trichosanthes dioica seed with a molecular mass of 39±1 kDa in the presence and absence of ß-mercaptoethanol. The enzyme was a glycoprotein in nature containing 8% neutral sugar. The N-terminal sequence was determined to be EINGGGA which did not match with other proteins. Amino acid analysis performed by LC-MS revealed that the protein was rich in leucine. The enzyme was stable at a wide range of pH (5.0-11.0) and temperature (30-90 °C). Chitinase activity was little bit inhibited in the presence of chelating agent EDTA (ethylenediaminetetraaceticacid), urea and Ca(2+). A strong fluorescence quenching effect was found when dithiothreitol and sodium dodecyl sulfate were added to the enzyme. TDSC showed antifungal activity against Aspergillus niger and Trichoderma sp. as tested by MTT assay and disc diffusion method.
[Mh] Termos MeSH primário: Antifúngicos/química
Antifúngicos/farmacologia
Quitinases/química
Quitinases/farmacologia
Extratos Vegetais/química
Extratos Vegetais/farmacologia
Sementes/química
Trichosanthes/química
[Mh] Termos MeSH secundário: Sequência de Aminoácidos
Quitinases/isolamento & purificação
Testes de Sensibilidade a Antimicrobianos por Disco-Difusão
Estabilidade Enzimática
Concentração de Íons de Hidrogênio
Cinética
Peso Molecular
Extratos Vegetais/isolamento & purificação
Domínios e Motivos de Interação entre Proteínas
Sementes/enzimologia
Especificidade por Substrato
Temperatura Ambiente
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Nm] Nome de substância:
0 (Antifungal Agents); 0 (Plant Extracts); EC 3.2.1.14 (Chitinases)
[Em] Mês de entrada:1610
[Cu] Atualização por classe:170103
[Lr] Data última revisão:
170103
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151216
[St] Status:MEDLINE


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[PMID]:26654829
[Au] Autor:Ma J; Mi C; Wang KS; Lee JJ; Jin X
[Ad] Endereço:Key Laboratory of Natural Resources of Changbai Mountain & Functional Molecules, Ministry of Education, College of Pharmacy, Yanbian University, Yanji 133002, Jilin Province, China; Molecular Cancer Research Center, Yanbian University, Yanji 133002, Jilin Province, China.
[Ti] Título:4',6-Dihydroxy-4-methoxyisoaurone inhibits TNF-α-induced NF-κB activation and expressions of NF-κB-regulated target gene products.
[So] Source:J Pharmacol Sci;130(2):43-50, 2016 Feb.
[Is] ISSN:1347-8648
[Cp] País de publicação:Japan
[La] Idioma:eng
[Ab] Resumo:The nuclear factor-κB (NF-κB) transcription factors control many physiological processes including inflammation, apoptosis, and angiogenesis. In our search for NF-κB inhibitors from natural resources, we identified 4',6-dihydroxy-4-methoxyisoaurone (ISOA) as an inhibitor of NF-κB activation from the seeds of Trichosanthes kirilowii. However, the mechanism by which ISOA inhibits NF-κB activation is not fully understood. In the present study, we demonstrated the effect of ISOA on NF-κB activation in TNF-α-stimulated HeLa cells. This compound suppressed NF-κB activation through the inhibition of IκB kinase (IKK) activation. ISOA also has an influence on upstream signaling of IKK through the inhibition of expression of adaptor proteins, TNF receptor-associated factor 2 (TRAF2) and receptor interacting protein 1 (RIP1). Consequently, ISOA blocked the phosphorylation and degradation of the inhibitor of NF-κB alpha (IκBα), and subsequent phosphorylation and nuclear translocation of p65. The suppression of NF-κB activation by ISOA led to the down-regulation of target genes involved in inflammation, proliferation, as well as potentiation of TNF-α-induced apoptosis. Taken together, this study extends our understanding on the mechanisms underlying the anti-inflammatory and anti-cancer activities of ISOA. Our findings provide new insight into the molecular mechanisms and a potential application of ISOA for inflammatory diseases as well as certain cancers.
[Mh] Termos MeSH primário: Expressão Gênica/efeitos dos fármacos
Expressão Gênica/genética
NF-kappa B/metabolismo
Sesquiterpenos/farmacologia
Fator de Necrose Tumoral alfa
[Mh] Termos MeSH secundário: Proteínas Adaptadoras de Transdução de Sinal/genética
Proteínas Adaptadoras de Transdução de Sinal/metabolismo
Apoptose/efeitos dos fármacos
Apoptose/genética
Proliferação Celular/efeitos dos fármacos
Proliferação Celular/genética
Células HeLa
Seres Humanos
Quinase I-kappa B/antagonistas & inibidores
Inflamação/tratamento farmacológico
Inflamação/genética
Neoplasias/tratamento farmacológico
Neoplasias/genética
Complexo de Proteínas Formadoras de Poros Nucleares/genética
Complexo de Proteínas Formadoras de Poros Nucleares/metabolismo
Fosforilação/efeitos dos fármacos
Fitoterapia
Proteínas de Ligação a RNA/genética
Proteínas de Ligação a RNA/metabolismo
Sementes/química
Sesquiterpenos/isolamento & purificação
Fator 2 Associado a Receptor de TNF/genética
Fator 2 Associado a Receptor de TNF/metabolismo
Fator de Transcrição RelA/metabolismo
Trichosanthes/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (4',6-dihydroxy-4-methoxyisoaurone); 0 (AGFG1 protein, human); 0 (Adaptor Proteins, Signal Transducing); 0 (NF-kappa B); 0 (Nuclear Pore Complex Proteins); 0 (RNA-Binding Proteins); 0 (Sesquiterpenes); 0 (TNF Receptor-Associated Factor 2); 0 (Transcription Factor RelA); 0 (Tumor Necrosis Factor-alpha); EC 2.7.11.10 (I-kappa B Kinase)
[Em] Mês de entrada:1612
[Cu] Atualização por classe:161230
[Lr] Data última revisão:
161230
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:151215
[St] Status:MEDLINE


  9 / 138 MEDLINE  
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[PMID]:27062809
[Au] Autor:Zhou J; Bian LH; Zou L; Zhou BQ; Liu W; Wang X
[Ti] Título:[Effect of smoke water and distillation liquid on the seed germination and seedling growth of Trichosathes kirilowii].
[So] Source:Zhongguo Zhong Yao Za Zhi;40(20):3958-62, 2015 Oct.
[Is] ISSN:1001-5302
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:Smoke water and distillation liquid were used to treat the seeds of Trichosathes kirilowii and to study the effects of smoke water and distillation liquid on the seed germination and seedling growth of T. kirilowii. The results showed that germination rate, germination index and germination vigor of T. kirilowii all were significantly improved with the treatment of SW and DL treatment. The activity of α-amylase were significantly increased with the treatment of SW and DL at 1:2,000. SW and DL treatment showed no significant effects on the activity of SOD. The activity of POD were markedly enhanced under the treatment of SW (1:000) and DL (1:2,000). CAT activity were increased with the treatment of SW and DL at 1:2,000 while were inhibited by SW and DL at 1:500. Seedling height and root length were increased with the treatment of SW and DL (1:1,000, 1:2,000). SW and DL treaments improved the content of chlorophyll, and moreover with the concentration of SW and DL, the stimulatory were also increased. This work demonstrated that smoke water and diatillation liquid at 1:2,000 could stimulate the seed germination and seedling growth of T. kirilowii, and it provided the references for the study of seed germination technology.
[Mh] Termos MeSH primário: Agricultura/métodos
Sementes/crescimento & desenvolvimento
Fumaça/análise
Trichosanthes/metabolismo
[Mh] Termos MeSH secundário: Agricultura/instrumentação
Destilação
Germinação
Plântulas/crescimento & desenvolvimento
Plântulas/metabolismo
Sementes/metabolismo
Trichosanthes/crescimento & desenvolvimento
Água/química
Água/metabolismo
[Pt] Tipo de publicação:ENGLISH ABSTRACT; EVALUATION STUDIES; JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Smoke); 059QF0KO0R (Water)
[Em] Mês de entrada:1605
[Cu] Atualização por classe:160411
[Lr] Data última revisão:
160411
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160412
[St] Status:MEDLINE


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[PMID]:26983235
[Au] Autor:Song YM; Li J; Li F
[Ti] Título:[Genetic Diversity and Genetic Relationship of Different Forms of Trichosanthes kirilowii from Shandong Province].
[So] Source:Zhong Yao Cai;38(8):1639-42, 2015 Aug.
[Is] ISSN:1001-4454
[Cp] País de publicação:China
[La] Idioma:chi
[Ab] Resumo:OBJECTIVE: To investigate the genetic diversity and genetic relationship of different forms of Trichosanthes kirilowii from Shandong Province. METHODS: Different forms of Trichosanthes kirilowii from the same planting base were detected by random amplified polymorphic DNA( RAPD) with eight random primers. The amplified bands were detected and the fingerprint was drawn by Biosens Gel Imaging System software. The Jaccard coefficient was worked out by using NTSYS-pc software, and a cluster dendrogram of different samples was established based on unweighted pair-group method with arithmetic means (UPGMA). RESULTS: The eight primers produced 56 bands, among which, 32 bands were polymorphic. The cluster dendrogram displayed there was some differences of genetic relationship of different samples. CONCLUSION: There is similar genetic material basis of Trichosanthes kirilowii from the same planting base, but also there is apparent individual differences.
[Mh] Termos MeSH primário: Variação Genética
Trichosanthes/genética
[Mh] Termos MeSH secundário: Primers do DNA
DNA de Plantas/genética
Plantas Medicinais/genética
Técnica de Amplificação ao Acaso de DNA Polimórfico
[Pt] Tipo de publicação:ENGLISH ABSTRACT; JOURNAL ARTICLE
[Nm] Nome de substância:
0 (DNA Primers); 0 (DNA, Plant)
[Em] Mês de entrada:1605
[Cu] Atualização por classe:160317
[Lr] Data última revisão:
160317
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:160318
[St] Status:MEDLINE



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