Base de dados : MEDLINE Pesquisa : B01.650.940.800.575.912.250.325.500 [Categoria DeCS] Referências encontradas : 690 [refinar] Mostrando: 1 .. 10   no formato [Detalhado]

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[PMID]: 29328647 [Au] Autor: Hsieh HL; Lee CH; Lin KC [Ad] Endereço: Department of Life Science, National Dong Hwa University , Hualien County 974, Taiwan. [Ti] Título: Development of Yam Dioscorin-Loaded Nanoparticles for Paracellular Transport Across Human Intestinal Caco-2 Cell Monolayers. [So] Source: J Agric Food Chem;66(5):1175-1183, 2018 Feb 07. [Is] ISSN: 1520-5118 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Dioscorins, the major storage proteins of yam tubers, exert immunomodulatory activities. To improve oral bioavailability of dioscorins in the intestine, recombinant dioscorin (rDioscorin) was coated with N,N,N-trimethyl chitosan (TMC) and tripolyphosphate (TPP), resulting in the formation of TMC-rDio-TPP nanoparticles (NPs). The loading capacity and entrapment efficiency of rDioscorin in the NPs were 26 ± 0.7% and 61 ± 1.4%, respectively. The NPs demonstrated a substantial release profile in the pH environment of the jejunum. The rDioscorin released from the NPs stimulated proliferation and phagocytosis of the macrophage RAW264.7 and activated the gene expression of IL-1ß and IL-6. Incubation of the NPs in the Caco-2 cell monolayer led to a 5.2-fold increase of P compared with rDioscorin alone, suggesting that rDioscorin, with the assistance of TMC, can be promptly transported across the intestinal epithelia. These results demonstrate that the TMC-rDio-TPP NPs can be utilized for elucidating the immunopharmacological effects of dioscorins through oral delivery. [Mh] Termos MeSH primário: Dioscorea/química Intestinos/metabolismo Nanopartículas/metabolismo Proteínas de Plantas/metabolismo [Mh] Termos MeSH secundário: Administração Oral Disponibilidade Biológica Transporte Biológico Células CACO-2 Proliferação Celular/efeitos dos fármacos Quitosana Expressão Gênica/efeitos dos fármacos Seres Humanos Concentração de Íons de Hidrogênio Interleucina-1beta/genética Interleucina-6/genética Mucosa Intestinal/metabolismo Nanopartículas/administração & dosagem Fagocitose/efeitos dos fármacos Proteínas de Plantas/administração & dosagem Proteínas de Plantas/farmacocinética Tubérculos/química Polifosfatos [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Interleukin-1beta); 0 (Interleukin-6); 0 (N-trimethyl chitosan chloride); 0 (Plant Proteins); 0 (Polyphosphates); 0 (dioscorin protein, Dioscorea); 9012-76-4 (Chitosan); NU43IAG5BC (triphosphoric acid) [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180226 [Lr] Data última revisão: 180226 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 180113 [St] Status: MEDLINE [do] DOI: 10.1021/acs.jafc.7b04150

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[PMID]: 29282980 [Au] Autor: Wu GC; Lin SY; Liang HJ; Hou WC [Ti] Título: 135-Day Interventions of Yam Dioscorin and the Dipeptide Asn-Trp (NW) To Reduce Weight Gains and Improve Impaired Glucose Tolerances in High-Fat Diet-Induced C57BL/6 Mice. [So] Source: J Agric Food Chem;66(3):645-652, 2018 Jan 24. [Is] ISSN: 1520-5118 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: The C57BL/6J mice were fed a 135-day normal diet or a high-fat diet (HFD) without, or concurrent with, a single yam dioscorin (80 mg/kg) or dipeptide NW (40 mg/kg) intervention every day. The final body weights (g) of mice were 26.1 ± 1.4, 34.97 ± 2.1, 31.75 ± 2.6, and 31.66 ± 3.1, respectively, for normal diet-fed, HFD-fed, dioscorin-intervened, and NW-intervened group. The mice in both intervened groups showed similar less weight gains and had significant differences (P < 0.05) compared to those in the HFD group under the same cumulative HFD intakes. The blood biochemical index of mice with dioscorin interventions showed significantly lower contents in total cholesterol and low-density lipoprotein, and NW interventions showed significantly lower total triglyceride contents compared to those of the HFD group (P < 0.05). Both intervened mice exhibited similar reductions in total visceral lipid contents and have significant differences compared to those of the HFD group (P < 0.05). The dioscorin intervention was better than NW interventions in lowering blood glucose levels by oral glucose tolerance tests and both showed significant differences (P < 0.05) compared to those in the HFD group. Yam dioscorin or dipeptide NW will potentially be used for preventive functional foods of less body weight gains and impaired glucose tolerance controls, which require further clinical trial investigations. [Mh] Termos MeSH primário: Dioscorea/química Dipeptídeos/administração & dosagem Obesidade/tratamento farmacológico Proteínas de Plantas/química [Mh] Termos MeSH secundário: Animais Glicemia/metabolismo Dieta Hiperlipídica/efeitos adversos Dipeptídeos/química Intolerância à Glucose Seres Humanos Lipoproteínas LDL/sangue Masculino Camundongos Camundongos Endogâmicos C57BL Obesidade/metabolismo Obesidade/fisiopatologia Proteínas de Plantas/administração & dosagem Triglicerídeos/sangue Ganho de Peso/efeitos dos fármacos [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Blood Glucose); 0 (Dipeptides); 0 (Lipoproteins, LDL); 0 (Plant Proteins); 0 (Triglycerides); 0 (dioscorin protein, Dioscorea) [Em] Mês de entrada: 1802 [Cu] Atualização por classe: 180207 [Lr] Data última revisão: 180207 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 171229 [St] Status: MEDLINE [do] DOI: 10.1021/acs.jafc.7b05564

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[PMID]: 28867088 [Au] Autor: Adepoju OT; Boyejo O; Adeniji PO [Ad] Endereço: Department of Human Nutrition, Faculty of Public Health, College of Medicine, University of Ibadan, Ibadan, Nigeria. Electronic address: tholadejo@yahoo.com. [Ti] Título: Effects of processing methods on nutrient and antinutrient composition of yellow yam (Dioscorea cayenensis) products. [So] Source: Food Chem;238:160-165, 2018 Jan 01. [Is] ISSN: 0308-8146 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: There is dearth of documented information on nutrient retention of Dioscorea cayenensis products. This study was carried out to evaluate effects of processing methods on nutrient and antinutrient retention of yellow yam products. Fresh Dioscorea cayenensis tubers were purchased from Bodija market in Ibadan, peeled, cut into small pieces, divided into nine portions. One portion was treated as raw sample, and others processed into local delicacies. All nine samples were analysed for proximate, mineral, vitamin and antinutrient composition using AOAC methods. Data were analysed using ANOVA at p=0.05. Raw yam contained 66.79g moisture, 2.62g crude protein, 0.27g lipid, 0.17g fibre, 0.63g ash, 29.69g carbohydrates, 262.30mg potassium, 61.53mg magnesium, 0.79mg iron, 0.39mg zinc, and yielded 108.26kcal energy with insignificant vitamin content/100g edible portion. Processing significantly improved macronutrients and energy content with significant reduction in all antinutrients of products (p<0.05). The yam products can serve as staple source of energy to consumers. [Mh] Termos MeSH primário: Dioscorea [Mh] Termos MeSH secundário: Fibras na Dieta Nigéria [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Dietary Fiber) [Em] Mês de entrada: 1711 [Cu] Atualização por classe: 171128 [Lr] Data última revisão: 171128 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170905 [St] Status: MEDLINE

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[PMID]: 28910661 [Au] Autor: Wang LL; Zhao DS; Shi W; Li ZQ; Wu ZT; Li P; Li HJ [Ad] Endereço: State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China. [Ti] Título: Describing the holistic toxicokinetics of hepatotoxic Chinese herbal medicines by a novel integrated strategy: Dioscorea bulbifera rhizome as a case study. [So] Source: J Chromatogr B Analyt Technol Biomed Life Sci;1064:40-48, 2017 Oct 01. [Is] ISSN: 1873-376X [Cp] País de publicação: Netherlands [La] Idioma: eng [Ab] Resumo: It is vital to monitor the holistic toxicokinetics of toxic Chinese herbal medicines (CHMs) for safety. Although an integrated strategy based on the area under the curve (AUC) has been proposed to characterize the pharmacokinetic/toxicokinetic properties of CHMs, improvement is still needed. This study attempted to use 50% inhibitory concentration (IC ) as weighting coefficient to investigate holistic toxicokinetics of the major diosbulbins i.e. diosbulbin A (DA), diosbulbin B (DB), and diosbulbin C (DC) after oral administration of Dioscorea bulbifera rhizome (DBR) extract. Firstly, the cytotoxicities of the three diosbulbins on human hepatic L02 cells were evaluated and the IC values were calculated. Then, integrated toxicokinetics of multiple diosbulbins based on AUC and IC were determined. Finally, correlations between integrated plasma concentrations and hepatic injury biomarkers including alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and total bile acid (TBA) were analyzed. As a result, integrated plasma concentrations were correlated well with TBA and the correlation between TBA and IC -weighting integrated plasma concentrations was better than that of AUC-weighting integrated plasma concentrations. In conclusion, the newly developed IC -weighting method is expected to generate more reasonable integrated toxicokinetic parameters, which will help to guide the safe usage of DBR in clinical settings. [Mh] Termos MeSH primário: Dioscorea/química Medicamentos de Ervas Chinesas Compostos Heterocíclicos de 4 ou mais Anéis/sangue Toxicocinética [Mh] Termos MeSH secundário: Animais Linhagem Celular Tumoral Cromatografia Líquida Medicamentos de Ervas Chinesas/administração & dosagem Medicamentos de Ervas Chinesas/farmacocinética Medicamentos de Ervas Chinesas/toxicidade Compostos Heterocíclicos de 4 ou mais Anéis/farmacocinética Compostos Heterocíclicos de 4 ou mais Anéis/toxicidade Seres Humanos Concentração Inibidora 50 Modelos Lineares Fígado/efeitos dos fármacos Fígado/patologia Masculino Espectrometria de Massas Ratos Ratos Sprague-Dawley Reprodutibilidade dos Testes Rizoma/química Sensibilidade e Especificidade [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Drugs, Chinese Herbal); 0 (Heterocyclic Compounds, 4 or More Rings); 20086-06-0 (diosbulbin B) [Em] Mês de entrada: 1710 [Cu] Atualização por classe: 171010 [Lr] Data última revisão: 171010 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170915 [St] Status: MEDLINE

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[PMID]: 28899093 [Au] Autor: Zhao DS; Jiang LL; Fan YX; Wang LL; Li ZQ; Shi W; Li P; Li HJ [Ad] Endereço: State Key Laboratory of Natural Medicines, China Pharmaceutical University , No. 24 Tongjia Lane, Nanjing 210009, China. [Ti] Título: Investigation of Dioscorea bulbifera Rhizome-Induced Hepatotoxicity in Rats by a Multisample Integrated Metabolomics Approach. [So] Source: Chem Res Toxicol;30(10):1865-1873, 2017 Oct 16. [Is] ISSN: 1520-5010 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: The use of herbal medicines continues to expand globally, meanwhile, herb-associated hepatotoxicity is becoming a safety issue. As a conventional Chinese medicinal herb, Dioscorea bulbifera rhizome (DBR) has been documented to cause hepatic toxicity. However, the exact underlying mechanism remains largely unexplored. In the present study, we aimed to profile entire endogenous metabolites in a biological system using a multisample integrated metabolomics strategy. Our findings offered additional insights into the molecular mechanism of the DBR-induced hepatotoxicity. We identified different metabolites from rat plasma, urine, and feces by employing gas chromatography-mass spectrometry in combination with multivariate analysis. In total, 55 metabolites distributed in 33 metabolic pathways were identified as being significantly altered in DBR-treated rats. Correlation network analysis revealed that the hub metabolites of hepatotoxicity were mainly associated with amino acid, bile acid, purine, pyrimidine, lipid, and energy metabolism. As such, DBR affected the physiological and biological functions of liver via the regulation of multiple metabolic pathways to an abnormal state. Notably, our findings also demonstrated that the multisample integrated metabolomics strategy has a great potential to identify more biomarkers and pathways in order to elucidate the mechanistic complexity of toxicity of traditional Chinese medicine. [Mh] Termos MeSH primário: Doença Hepática Induzida por Substâncias e Drogas/metabolismo Dioscorea/química Medicamentos de Ervas Chinesas/toxicidade Fígado/efeitos dos fármacos Metabolômica Rizoma/química [Mh] Termos MeSH secundário: Animais Doença Hepática Induzida por Substâncias e Drogas/patologia Medicamentos de Ervas Chinesas/administração & dosagem Fígado/metabolismo Fígado/patologia Masculino Ratos Ratos Sprague-Dawley [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Drugs, Chinese Herbal) [Em] Mês de entrada: 1711 [Cu] Atualização por classe: 171101 [Lr] Data última revisão: 171101 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170914 [St] Status: MEDLINE [do] DOI: 10.1021/acs.chemrestox.7b00176

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[PMID]: 28844483 [Au] Autor: Yang R; Yang F; Huang Z; Jin Y; Sheng Y; Ji L [Ad] Endereço: Center for Drug Safety Evaluation and Research, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, China; MOE Key Laboratory for Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, 1200 C [Ti] Título: Serum microRNA-122-3p, microRNA-194-5p and microRNA-5099 are potential toxicological biomarkers for the hepatotoxicity induced by Airpotato yam. [So] Source: Toxicol Lett;280:125-132, 2017 Oct 05. [Is] ISSN: 1879-3169 [Cp] País de publicação: Netherlands [La] Idioma: eng [Ab] Resumo: Airpotato yam (the rhizome of Dioscorea bulbifera L.) is traditionally used to treat thyroid disease and various cancers in China. However, it was found to cause hepatotoxicity during clinical practice. This study aims to identify candidate serum microRNAs (miRNAs) as diagnostic biomarkers for the liver injury induced by Airpotato yam. The results of serum alanine/aspartate aminotransferase (ALT/AST) showed the remarkable hepatotoxicity induced by ethyl acetate fraction of Airpotato yam (EF) (450mg/kg) and diosbulbin B (DB) (300mg/kg) in mice. The results of miRNAs chip analysis showed that the expression of 28 and 37 serum miRNAs was obviously altered in EF- and DB-treated mice, respectively. Among these miRNAs, miRNA-122-3p, miR-194-3p and miR-5099 have passed the further validation in serum from both EF- and DB-treated mice. Moreover, the expression of miRNA-122-3p and miRNA-194-5p was significantly increased in EF (375mg/kg)-treated mice with no significant elevation of serum ALT/AST activity. Only the expression of serum miRNA-5099 was not altered in the liver injury induced by acetaminophen (APAP), monocrotaline (MCT) or toosendanin (TSN). In conclusion, this study demonstrated that miR-122-3p and miRNA-194-5p were two sensitive biomarkers, and miR-5099 might be a specific biomarker for reflecting the liver injury induced by Airpotato yam. [Mh] Termos MeSH primário: Doença Hepática Induzida por Substâncias e Drogas/metabolismo Dioscorea/toxicidade MicroRNAs/metabolismo Extratos Vegetais/toxicidade [Mh] Termos MeSH secundário: Animais Biomarcadores Doença Hepática Induzida por Substâncias e Drogas/sangue Medicamentos de Ervas Chinesas Regulação da Expressão Gênica Compostos Heterocíclicos de 4 ou mais Anéis/toxicidade Camundongos Camundongos Endogâmicos C57BL Camundongos Endogâmicos ICR MicroRNAs/genética Distribuição Aleatória Transcriptoma [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Biomarkers); 0 (Drugs, Chinese Herbal); 0 (Heterocyclic Compounds, 4 or More Rings); 0 (MicroRNAs); 0 (Plant Extracts); 20086-06-0 (diosbulbin B) [Em] Mês de entrada: 1710 [Cu] Atualização por classe: 171017 [Lr] Data última revisão: 171017 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170829 [St] Status: MEDLINE

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[PMID]: 28606759 [Au] Autor: Li X; Zhao C; Jing S; Sun J; Li X; Man S; Wang Y; Gao W [Ad] Endereço: Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, China. [Ti] Título: Novel phenanthrene and isocoumarin from the rhizomes of Dioscorea nipponica Makino subsp. rosthornii (Prain et Burkill) C. T. Ting (Dioscoreaceae). [So] Source: Bioorg Med Chem Lett;27(15):3595-3601, 2017 08 01. [Is] ISSN: 1464-3405 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: The investigation of the constituents in the rhizomes of Dioscorea nipponica Makino subsp. rosthornii (Prain et Burkill) C. T. Ting afforded one new phenanthrene 2,2',7,7'-tetramethoxy-[1,1'-biphenanthrene]-4,4',6,6'-tetrol (7) and one new isocoumarin diorosthornoumarin (8), together with 16 known compounds (1-6 and 9-18). Their structures were established on the basis of extensive spectroscopic evidences (IR, HR-ESI-MS, NMR and optical rotation), as well as comparison with literature values. All the compounds 1-18 were firstly isolated from Dioscorea nipponica Makino subsp. Rosthornii (Prain et Burkill) C. T. Ting, and compound 9 was firstly obtained as a natural product from plants, while the compounds 11 and 14 were obtained from both the genus Dioscorea and the family Dioscoreaceae for the first time. Moreover, the antitumor activities of the compounds were tested against lung carcinoma NCI-H460 cell line. Compound 12, 13, 15 and 16 showed significant cytotoxic activities, whereas 7 displayed moderate cytotoxicity. [Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/química Dioscorea/química Isocumarinas/química Fenantrenos/química Rizoma/química [Mh] Termos MeSH secundário: Antineoplásicos Fitogênicos/isolamento & purificação Antineoplásicos Fitogênicos/farmacologia Linhagem Celular Tumoral Seres Humanos Isocumarinas/farmacologia Pulmão/efeitos dos fármacos Neoplasias Pulmonares/tratamento farmacológico Fenantrenos/isolamento & purificação Fenantrenos/farmacologia Extratos Vegetais/química Extratos Vegetais/isolamento & purificação Extratos Vegetais/farmacologia [Pt] Tipo de publicação: JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T [Nm] Nome de substância: 0 (1,1'-biphenanthrene); 0 (Antineoplastic Agents, Phytogenic); 0 (Isocoumarins); 0 (Phenanthrenes); 0 (Plant Extracts) [Em] Mês de entrada: 1708 [Cu] Atualização por classe: 171125 [Lr] Data última revisão: 171125 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170614 [St] Status: MEDLINE

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[PMID]: 28577480 [Au] Autor: Xiao C; Fan W; Du S; Liu L; Wang C; Guo M; Zhang L; Zhang M; Yu L [Ad] Endereço: Institute of Resource Biology and Biotechnology, Department of Biotechnology, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China; Key Laboratory of Molecular Biophysics Ministry of Education, Huazhong University of Science and Technology, Wuhan [Ti] Título: A novel glycosylated solution from Dioscorea zingiberensis C.H. Wright significantly improves the solvent productivity of Clostridium beijerinckii. [So] Source: Bioresour Technol;241:317-324, 2017 Oct. [Is] ISSN: 1873-2976 [Cp] País de publicação: England [La] Idioma: eng [Ab] Resumo: The economics of bio-solvent production are largely dependent on the cost of the fermentation substrate. Dioscorea zingiberensis C.H. Wright (DZW), the main raw material used to produce saponin, contains 13-18% starch which can be directly saccharified to a saccharification liquid of DZW starch (SLDS) that contains abundant nutrients. In this study, the water-soluble micromolecule compounds in SLDS were quantified through H NMR. Using SLDS as the substrate to conduct ABE fermentation by Clostridium beijerinckii, the fermentation cycle was shortened 24h, the maximum biomass and consumption rate of the glucose significantly increased, and the productivity of total solvents were increased by 0.244±0.010g/L/h compared to standard P medium. Expression analysis of genes encoding key enzymes involved in acetone and butanol production and glucose consumption showed that they were induced by SLDS. Taken together, SLDS is a useful and renewable glycosylated solution for ABE fermentation. [Mh] Termos MeSH primário: Clostridium beijerinckii Dioscorea Solventes [Mh] Termos MeSH secundário: Acetona Butanóis Etanol Fermentação [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Butanols); 0 (Solvents); 1364PS73AF (Acetone); 3K9958V90M (Ethanol) [Em] Mês de entrada: 1711 [Cu] Atualização por classe: 171106 [Lr] Data última revisão: 171106 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170604 [St] Status: MEDLINE

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[PMID]: 28477535 [Au] Autor: Zhang Z; Lin D; Li W; Gao H; Peng Y; Zheng J [Ad] Endereço: Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang 110016, PR China. [Ti] Título: Sensitive bromine-based screening of potential toxic furanoids in Dioscorea bulbifera L. [So] Source: J Chromatogr B Analyt Technol Biomed Life Sci;1057:1-14, 2017 Jul 01. [Is] ISSN: 1873-376X [Cp] País de publicação: Netherlands [La] Idioma: eng [Ab] Resumo: Numerous furanoids have been reported to be toxic, and many of them were found in herbal medicines. Toxicities of furanoids are suggested to result from the generation of cis-enedials via biotransformation. The detection of the electrophilic metabolic intermediates is a challenge. Earlier, we developed a selective approach to screen potential toxic furanoids, through which we found two major furanoids, diosbulbin B and 8-epidiosbulbin E acetate, in Dioscorea bulbifera L., a known furanoid-containing and hepatotoxic herbal medicine. In the present study, we improved the approach to analyze furanoids in D. bulbifera L., which allowed us to detect additional six potential furanoids, including diosbulbin A, diosbulbin D, diosbulbin E, diosbulbin F, diosbulbin M, and diosbulbin D glycoside. The achievements of this study enhanced the sensitivity to screen potential toxic furanoids through elevating S/N values by approximately 3 times. This will facilitate the understanding of mechanisms of toxic actions of D. bulbifera L. and other furanoid-containing toxic herbal medicines. [Mh] Termos MeSH primário: Bromo Dioscorea/química Diterpenos/análise Furanos/análise Compostos Heterocíclicos de 4 ou mais Anéis/análise Lactonas/análise [Mh] Termos MeSH secundário: Animais Bromo/análise Bromo/química Células Cultivadas Medicamentos de Ervas Chinesas/efeitos adversos Medicamentos de Ervas Chinesas/química Microssomos Hepáticos/química Extratos Vegetais/química Extratos Vegetais/toxicidade Ratos Ratos Sprague-Dawley Sensibilidade e Especificidade Espectrometria de Massas em Tandem Testes de Toxicidade [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (8-epidiosbulbin E acetate); 0 (Diterpenes); 0 (Drugs, Chinese Herbal); 0 (Furans); 0 (Heterocyclic Compounds, 4 or More Rings); 0 (Lactones); 0 (Plant Extracts); 20086-06-0 (diosbulbin B); SBV4XY874G (Bromine) [Em] Mês de entrada: 1707 [Cu] Atualização por classe: 170718 [Lr] Data última revisão: 170718 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170507 [St] Status: MEDLINE

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[PMID]: 28355293 [Au] Autor: Arnau G; Bhattacharjee R; Mn S; Chair H; Malapa R; Lebot V; K A; Perrier X; Petro D; Penet L; Pavis C [Ad] Endereço: Unité Mixte de Recherche Amélioration Génétique et Adaptation des Plantes (UMR Agap), Centre de Coopération International en Recherche Agronomique pour le Développement (CIRAD), Station de Roujol, Petit Bourg, Guadeloupe, France. [Ti] Título: Understanding the genetic diversity and population structure of yam (Dioscorea alata L.) using microsatellite markers. [So] Source: PLoS One;12(3):e0174150, 2017. [Is] ISSN: 1932-6203 [Cp] País de publicação: United States [La] Idioma: eng [Ab] Resumo: Yams (Dioscorea sp.) are staple food crops for millions of people in tropical and subtropical regions. Dioscorea alata, also known as greater yam, is one of the major cultivated species and most widely distributed throughout the tropics. Despite its economic and cultural importance, very little is known about its origin, diversity and genetics. As a consequence, breeding efforts for resistance to its main disease, anthracnose, have been fairly limited. The objective of this study was to contribute to the understanding of D. alata genetic diversity by genotyping 384 accessions from different geographical regions (South Pacific, Asia, Africa and the Caribbean), using 24 microsatellite markers. Diversity structuration was assessed via Principal Coordinate Analysis, UPGMA analysis and the Bayesian approach implemented in STRUCTURE. Our results revealed the existence of a wide genetic diversity and a significant structuring associated with geographic origin, ploidy levels and morpho-agronomic characteristics. Seventeen major groups of genetically close cultivars have been identified, including eleven groups of diploid cultivars, four groups of triploids and two groups of tetraploids. STRUCTURE revealed the existence of six populations in the diploid genetic pool and a few admixed cultivars. These results will be very useful for rationalizing D. alata genetic resources in breeding programs across different regions and for improving germplasm conservation methods. [Mh] Termos MeSH primário: Colletotrichum/fisiologia Dioscorea/genética Resistência à Doença/genética Variação Genética Filogenia [Mh] Termos MeSH secundário: África Ásia Teorema de Bayes Região do Caribe Colletotrichum/patogenicidade Produtos Agrícolas Dioscorea/classificação Dioscorea/microbiologia Marcadores Genéticos Repetições de Microssatélites Filogeografia Melhoramento Vegetal Doenças das Plantas/genética Doenças das Plantas/microbiologia Ploidias Análise de Componente Principal [Pt] Tipo de publicação: JOURNAL ARTICLE [Nm] Nome de substância: 0 (Genetic Markers) [Em] Mês de entrada: 1708 [Cu] Atualização por classe: 170829 [Lr] Data última revisão: 170829 [Sb] Subgrupo de revista: IM [Da] Data de entrada para processamento: 170330 [St] Status: MEDLINE [do] DOI: 10.1371/journal.pone.0174150

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1			PalavrasDescritor de assuntoDescritor de assunto primárioLimitesAutorPalavras do títuloPalavras do resumoIdiomaPaís de publicaçãoNome de substânciaNome de pessoa como assuntoRevistaAssunto de RevistaISSNTipo de publicaçãoIdentificador únicoMês de entradaAno de publicaçãoTexto completoAtualização por classeCategoria DeCSCategoria DeCS explodidaCategoria CID-10SubSetsPais de AfiliaçãoAfiliaçãoAfiliação 2
2	and or and not		PalavrasDescritor de assuntoDescritor de assunto primárioLimitesAutorPalavras do títuloPalavras do resumoIdiomaPaís de publicaçãoNome de substânciaNome de pessoa como assuntoRevistaAssunto de RevistaISSNTipo de publicaçãoIdentificador únicoMês de entradaAno de publicaçãoTexto completoAtualização por classeCategoria DeCSCategoria DeCS explodidaCategoria CID-10SubSetsPais de AfiliaçãoAfiliaçãoAfiliação 2
3	and or and not		PalavrasDescritor de assuntoDescritor de assunto primárioLimitesAutorPalavras do títuloPalavras do resumoIdiomaPaís de publicaçãoNome de substânciaNome de pessoa como assuntoRevistaAssunto de RevistaISSNTipo de publicaçãoIdentificador únicoMês de entradaAno de publicaçãoTexto completoAtualização por classeCategoria DeCSCategoria DeCS explodidaCategoria CID-10SubSetsPais de AfiliaçãoAfiliaçãoAfiliação 2

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