Base de dados : MEDLINE
Pesquisa : B01.650.940.800.575.912.250.325.750 [Categoria DeCS]
Referências encontradas : 6 [refinar]
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  1 / 6 MEDLINE  
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[PMID]:25633370
[Au] Autor:Zerargui F; Boumerfeg S; Charef N; Baghiani A; Djarmouni M; Khennouf S; Arrar L; Abu Zarga MH; Mubarak MS
[Ti] Título:Antioxidant Potentials and Xanthine Oxidase Inhibitory Effect of Two Furanocoumarins Isolated from Tamus communis L.
[So] Source:Med Chem;11(5):506-13, 2015.
[Is] ISSN:1875-6638
[Cp] País de publicação:Netherlands
[La] Idioma:eng
[Ab] Resumo:In this investigation, the screening of two furanocoumarins; 5,8- dimethoxypsoralen (1) and heraclinin (2), isolated from the methanol root-extracts of Tamus communis L for their antioxidant activity and xanthine oxidase inhibitory effect was carried out, using different assays such as DPPH free radical scavenging effect, ß- carotene / linoleic acid, xanthine oxidase (XO) inhibition and in addition to blood total antioxidant capacity. Results revealed that the two compounds have significant DPPH radical scavenging activity and effective inhibition of linoleic acid oxidation in a dose-dependent manner; 5,8-dimethoxypsoralen exhibited the highest activity with an I% = 72.69 ± 1.88%. These results indicate that the isolated compounds inhibit xanthine oxidase activity and scavenge superoxide radicals with heraclinin (2) as the more potent xanthine oxidase inhibitor, and 5,8-dimethoxypsoralen (1) as the more effective on cytochrome c reduction, the two tested compounds can effectively protect erythrocytes against hemolytic injury induced by AAPH. These results are promising for further studies of the biological and pathological effects of these natural products.
[Mh] Termos MeSH primário: Furocumarinas/isolamento & purificação
Furocumarinas/farmacologia
Extratos Vegetais/farmacologia
Tamus/química
Xantina Oxidase/antagonistas & inibidores
[Mh] Termos MeSH secundário: Antioxidantes/química
Antioxidantes/isolamento & purificação
Antioxidantes/farmacologia
Furocumarinas/química
Furocumarinas/classificação
Extratos Vegetais/química
Raízes de Plantas/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antioxidants); 0 (Furocoumarins); 0 (Plant Extracts); 0 (heraclinin); 20GCF755G6 (isopimpinellin); EC 1.17.3.2 (Xanthine Oxidase)
[Em] Mês de entrada:1604
[Cu] Atualização por classe:150703
[Lr] Data última revisão:
150703
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:150131
[St] Status:MEDLINE


  2 / 6 MEDLINE  
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[PMID]:23152306
[Au] Autor:García-Herrera P; Sánchez-Mata MC; Cámara M; Tardío J; Olmedilla-Alonso B
[Ad] Endereço:Departamento de Nutrición y Bromatología II, Facultad de Farmacia, Universidad Complutense de Madrid, Plaza de Ramón y Cajal s/n, 28040-Madrid, Spain.
[Ti] Título:Carotenoid content of wild edible young shoots traditionally consumed in Spain (Asparagus acutifolius L., Humulus lupulus L., Bryonia dioica Jacq. and Tamus communis L.).
[So] Source:J Sci Food Agric;93(7):1692-8, 2013 May.
[Is] ISSN:1097-0010
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:BACKGROUND: Wild vegetables have traditionally been consumed as part of the Mediterranean diet, being valuable sources of nutrients and bioactive compounds. The objective of this work was to analyse the carotenoid content of the edible young shoots of four species (Asparagus acutifolius L., Humulus lupulus L., Bryonia dioica Jacq. and Tamus communis L.) as part of a wider study on the characterisation of the nutritional composition of wild edible plants commonly consumed in Spain. Samples were gathered from two locations in Central Spain for two consecutive years. RESULTS: Lutein, ß-carotene, neoxanthin and violaxanthin were quantified by high-performance liquid chromatography with a photodiode array detector. Median concentration ranges (µg g(-1) edible wet weight) were: ß-carotene, 3.39-6.69, lutein, 5.44­19.13;neoxanthin, 5.17-17.37; and violaxanthin, 2.08-8.93. The highest carotenoid content was that of B. dioica (59.01 µg g(-1)) and the lowest was found in A. acutifolius (17.58 µg g(-1)) [corrected]. CONCLUSION: Our results show that these wild young shoots are richer sources of carotenoids than many of the commercially available leafy vegetables.
[Mh] Termos MeSH primário: Asparagus (Planta)/química
Bryonia/química
Dieta
Humulus/química
Tamus/química
Xantofilas/análise
beta Caroteno/análise
[Mh] Termos MeSH secundário: Cromatografia Líquida de Alta Pressão
Seres Humanos
Luteína/análise
Brotos de Planta/química
Espanha
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Xanthophylls); 01YAE03M7J (beta Carotene); 51C926029A (violaxanthin); KK8M5T48AI (neoxanthin); X72A60C9MT (Lutein)
[Em] Mês de entrada:1310
[Cu] Atualização por classe:151119
[Lr] Data última revisão:
151119
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:121116
[St] Status:MEDLINE
[do] DOI:10.1002/jsfa.5952


  3 / 6 MEDLINE  
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[PMID]:21881939
[Au] Autor:Menzel W; Winter S
[Ad] Endereço:Plant Virus Department, DSMZ, Inhoffenstrasse 7B, 38124 Braunschweig, Germany. wulf.menzel@DSMZ.de
[Ti] Título:Sequencing of the Tamus red mosaic virus genome: further evidence that it is a distinct species of the genus Potexvirus.
[So] Source:Virus Genes;44(1):120-3, 2012 Feb.
[Is] ISSN:1572-994X
[Cp] País de publicação:United States
[La] Idioma:eng
[Ab] Resumo:In 1993, a virus causing red mosaic and leaf distortion has been isolated from black bryony (Tamus communis) in Italy. Based on particle properties and serology, the virus was assigned to the genus Potexvirus and named Tamus red mosaic virus (TRMV), pending a genome sequence. The original Italian TRMV isolate was submitted to the DSMZ plant virus collection (PV-0397). To confirm the taxonomic status of the virus, the entire genome sequence was determined comprising 6,495 nucleotides excluding the poly(A)-tail. Five putative open reading frames (ORFs) in an arrangement typical for potexviruses were predicted. TRMV is closely related to but distinct from Clover yellow mosaic virus and Allium virus X. In addition to previous morphological and serological characterization, the results presented in this study further reinforce the classification of TRMV as a distinct virus species of the genus Potexvirus.
[Mh] Termos MeSH primário: Genoma Viral
Doenças das Plantas/virologia
Potexvirus/classificação
Potexvirus/genética
Tamus/virologia
[Mh] Termos MeSH secundário: Sequência de Bases
Dados de Sequência Molecular
Fases de Leitura Aberta
Filogenia
Potexvirus/isolamento & purificação
Análise de Sequência de DNA
[Pt] Tipo de publicação:JOURNAL ARTICLE
[Em] Mês de entrada:1205
[Cu] Atualização por classe:171102
[Lr] Data última revisão:
171102
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:110902
[St] Status:MEDLINE
[do] DOI:10.1007/s11262-011-0664-y


  4 / 6 MEDLINE  
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[PMID]:18844260
[Au] Autor:Boumerfeg S; Baghiani A; Messaoudi D; Khennouf S; Arrar L
[Ad] Endereço:Laboratory of Applied Biochemistry, Department of Biology, Faculty of Sciences, University Ferhat Abbas of Setif 19000, Algeria.
[Ti] Título:Antioxidant properties and xanthine oxidase inhibitory effects of Tamus communis L. root extracts.
[So] Source:Phytother Res;23(2):283-8, 2009 Feb.
[Is] ISSN:1099-1573
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:This study was conducted to search for xanthine oxidase (XO) inhibitors from the root extracts of Tamus communis L. traditionally used in folk medicine in Algeria. Root extracts with different solvents were screened for purified milk xanthine oxidase inhibition. The root extracts (methanol, chloroform and ethyl acetate) and proteins, obtained in distilled water, inhibited bovine, sheep and human milk XO from three species in a concentration-dependent manner, with an additional superoxide scavenging capacity, which reached its highest level with ethyl acetate extract (IC(50) = 0.15, 0.04 and 0.09 g/L) for bovine XO, sheep XO and human XO, respectively. The antioxidant potential was confirmed with the non-enzymatic method, total radical-trapping antioxidant parameter (TRAP) assay, which showed that the Tamus communis L. extracts have a potential antioxidant activity in the same order obtained by using the reduction of cytochrome c, an enzymatic method, in which the antioxidant activity followed a decreasing order: ethyl acetate extract > chloroform extract > protein.
[Mh] Termos MeSH primário: Antioxidantes/farmacologia
Extratos Vegetais/farmacologia
Tamus/química
Xantina Oxidase/antagonistas & inibidores
[Mh] Termos MeSH secundário: Argélia
Animais
Bovinos
Relação Dose-Resposta a Droga
Flavonoides/isolamento & purificação
Depuradores de Radicais Livres/farmacologia
Seres Humanos
Medicina Tradicional
Leite/enzimologia
Fenóis/isolamento & purificação
Raízes de Plantas/química
Polifenóis
Ovinos
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antioxidants); 0 (Flavonoids); 0 (Free Radical Scavengers); 0 (Phenols); 0 (Plant Extracts); 0 (Polyphenols); EC 1.17.3.2 (Xanthine Oxidase)
[Em] Mês de entrada:0902
[Cu] Atualização por classe:111117
[Lr] Data última revisão:
111117
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:081011
[St] Status:MEDLINE
[do] DOI:10.1002/ptr.2621


  5 / 6 MEDLINE  
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[PMID]:17166530
[Au] Autor:Kovács A; Forgo P; Zupkó I; Réthy B; Falkay G; Szabó P; Hohmann J
[Ad] Endereço:Department of Pharmacognosy, University of Szeged, Eötvös u. 6, H-6720 Szeged, Hungary.
[Ti] Título:Phenanthrenes and a dihydrophenanthrene from Tamus communis and their cytotoxic activity.
[So] Source:Phytochemistry;68(5):687-91, 2007 Mar.
[Is] ISSN:0031-9422
[Cp] País de publicação:England
[La] Idioma:eng
[Ab] Resumo:From the petroleum ether extract of the rhizomes of Tamus communis, the 7-hydroxy-2,3,4,8-tetramethoxyphenanthrene (1) was isolated, together with the known 2,3,4-trimethoxy-7,8-methylenedioxyphenanthrene (2), 3-hydroxy-2,4,-dimethoxy-7,8-methylenedioxyphenanthrene (3), 2-hydroxy-3,5,7-trimethoxyphenanthrene (4) and 2-hydroxy-3,5,7-trimethoxy-9,10-dihydrophenanthrene (5), through cytotoxic assay guidance. The structures were determined by means of HREIMS, (1)H NMR, JMOD and NOESY experiments. The cytotoxic effects of the isolated compounds were tested on cervix adenocarcinoma (HeLa) cells, with the MTT assay. The results demonstrated that, with the exception of 2, all these compounds displayed pronounced cytotoxic activity; especially 1 and 3 exhibited significant cell growth inhibitory effects, with IC(50)=8.52+/-0.70 and 3.64+/-0.12 microM, respectively.
[Mh] Termos MeSH primário: Sobrevivência Celular/efeitos dos fármacos
Fenantrenos/isolamento & purificação
Fenantrenos/farmacologia
Tamus/química
[Mh] Termos MeSH secundário: Combretum/química
Células HeLa
Seres Humanos
Espectroscopia de Ressonância Magnética
Modelos Moleculares
Conformação Molecular
Fenantrenos/química
Extratos Vegetais/química
Extratos Vegetais/isolamento & purificação
Rizoma/química
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Phenanthrenes); 0 (Plant Extracts)
[Em] Mês de entrada:0706
[Cu] Atualização por classe:070223
[Lr] Data última revisão:
070223
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:061215
[St] Status:MEDLINE


  6 / 6 MEDLINE  
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[PMID]:16783700
[Au] Autor:Réthy B; Kovács A; Zupkó I; Forgo P; Vasas A; Falkay G; Hohmann J
[Ad] Endereço:Department of Pharmacodynamics and Biopharmacy, University of Szeged, Szeged, Hungary.
[Ti] Título:Cytotoxic phenanthrenes from the rhizomes of Tamus communis.
[So] Source:Planta Med;72(8):767-70, 2006 Jun.
[Is] ISSN:0032-0943
[Cp] País de publicação:Germany
[La] Idioma:eng
[Ab] Resumo:From the fresh rhizomes of Tamus communis five phenanthrenes (1 - 5) were isolated under the guidance of cytotoxic assays in HeLa cells. The compounds were obtained from the highly active CHCl (3) fraction of the MeOH extract by using multistep chromatographic purifications, including VLC, preparative TLC, HPLC and gel filtration. The compounds were identified by means of EI-mass, UV and NMR spectroscopy as 7-hydroxy-2,3,4-trimethoxyphenanthrene (1), 2,7-dihydroxy-3,4-dimethoxyphenanthrene (nudol) (2), 2,7-dihydroxy-3,4,8-trimethoxyphenanthrene (3), 3,7-dihydroxy-2,4,8-trimethoxyphenanthrene (confusarin) (4), and 3,7-dihydroxy-2,4-dimethoxyphenanthrene (5). Compound 1 is a new natural product, and 2 - 4 were isolated for the first time from T. communis. In the cytotoxic assays, compounds 1 - 3 and 5 significantly inhibited the growth of HeLa cells (IC (50) = 0.97 - 20.18 microM). Compound 3, with an IC (50) value of 0.97 microM, is of special interest because of its high activity.
[Mh] Termos MeSH primário: Antineoplásicos Fitogênicos/farmacologia
Fitoterapia
Extratos Vegetais/farmacologia
Tamus
[Mh] Termos MeSH secundário: Antineoplásicos Fitogênicos/administração & dosagem
Antineoplásicos Fitogênicos/uso terapêutico
Células HeLa/efeitos dos fármacos
Seres Humanos
Concentração Inibidora 50
Fenantrenos/administração & dosagem
Fenantrenos/farmacologia
Fenantrenos/uso terapêutico
Extratos Vegetais/administração & dosagem
Extratos Vegetais/uso terapêutico
Rizoma
[Pt] Tipo de publicação:JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T
[Nm] Nome de substância:
0 (Antineoplastic Agents, Phytogenic); 0 (Phenanthrenes); 0 (Plant Extracts)
[Em] Mês de entrada:0610
[Cu] Atualização por classe:061115
[Lr] Data última revisão:
061115
[Sb] Subgrupo de revista:IM
[Da] Data de entrada para processamento:060620
[St] Status:MEDLINE



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