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[PMID]: | 17166530 |
[Au] Autor: | Kovács A; Forgo P; Zupkó I; Réthy B; Falkay G; Szabó P; Hohmann J |
[Ad] Endereço: | Department of Pharmacognosy, University of Szeged, Eötvös u. 6, H-6720 Szeged, Hungary. |
[Ti] Título: | Phenanthrenes and a dihydrophenanthrene from Tamus communis and their cytotoxic activity. |
[So] Source: | Phytochemistry;68(5):687-91, 2007 Mar. | [Is] ISSN: | 0031-9422 |
[Cp] País de publicação: | England |
[La] Idioma: | eng |
[Ab] Resumo: | From the petroleum ether extract of the rhizomes of Tamus communis, the 7-hydroxy-2,3,4,8-tetramethoxyphenanthrene (1) was isolated, together with the known 2,3,4-trimethoxy-7,8-methylenedioxyphenanthrene (2), 3-hydroxy-2,4,-dimethoxy-7,8-methylenedioxyphenanthrene (3), 2-hydroxy-3,5,7-trimethoxyphenanthrene (4) and 2-hydroxy-3,5,7-trimethoxy-9,10-dihydrophenanthrene (5), through cytotoxic assay guidance. The structures were determined by means of HREIMS, (1)H NMR, JMOD and NOESY experiments. The cytotoxic effects of the isolated compounds were tested on cervix adenocarcinoma (HeLa) cells, with the MTT assay. The results demonstrated that, with the exception of 2, all these compounds displayed pronounced cytotoxic activity; especially 1 and 3 exhibited significant cell growth inhibitory effects, with IC(50)=8.52+/-0.70 and 3.64+/-0.12 microM, respectively. |
[Mh] Termos MeSH primário: |
Sobrevivência Celular/efeitos dos fármacos Fenantrenos/isolamento & purificação Fenantrenos/farmacologia Tamus/química
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[Mh] Termos MeSH secundário: |
Combretum/química Células HeLa Seres Humanos Espectroscopia de Ressonância Magnética Modelos Moleculares Conformação Molecular Fenantrenos/química Extratos Vegetais/química Extratos Vegetais/isolamento & purificação Rizoma/química
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[Pt] Tipo de publicação: | JOURNAL ARTICLE; RESEARCH SUPPORT, NON-U.S. GOV'T |
[Nm] Nome de substância:
| 0 (Phenanthrenes); 0 (Plant Extracts) |
[Em] Mês de entrada: | 0706 |
[Cu] Atualização por classe: | 070223 |
[Lr] Data última revisão:
| 070223 |
[Sb] Subgrupo de revista: | IM |
[Da] Data de entrada para processamento: | 061215 |
[St] Status: | MEDLINE |
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